ID A0A086MHC6_9HYPH Unreviewed; 338 AA. AC A0A086MHC6; DT 29-OCT-2014, integrated into UniProtKB/TrEMBL. DT 29-OCT-2014, sequence version 1. DT 25-MAY-2022, entry version 22. DE RecName: Full=2-dehydropantoate 2-reductase {ECO:0000256|ARBA:ARBA00019465}; DE EC=1.1.1.169 {ECO:0000256|ARBA:ARBA00013014}; DE AltName: Full=Ketopantoate reductase {ECO:0000256|ARBA:ARBA00032024}; GN ORFNames=JH26_17185 {ECO:0000313|EMBL:KFG68294.1}; OS Microvirga sp. BSC39. OC Bacteria; Proteobacteria; Alphaproteobacteria; Hyphomicrobiales; OC Methylobacteriaceae; Microvirga; unclassified Microvirga. OX NCBI_TaxID=1549810 {ECO:0000313|EMBL:KFG68294.1, ECO:0000313|Proteomes:UP000028825}; RN [1] {ECO:0000313|EMBL:KFG68294.1, ECO:0000313|Proteomes:UP000028825} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=BSC39 {ECO:0000313|EMBL:KFG68294.1, RC ECO:0000313|Proteomes:UP000028825}; RA Kellom M., Bailey A., Poret-Peterson A., Noonan K., Raymond J.; RT "Draft Genome of Microvirga aerilata BSC39, Isolated from Biological Soil RT Crust of Moab, Utah."; RL Submitted (AUG-2014) to the EMBL/GenBank/DDBJ databases. CC -!- CATALYTIC ACTIVITY: CC Reaction=(R)-pantoate + NADP(+) = 2-dehydropantoate + H(+) + NADPH; CC Xref=Rhea:RHEA:16233, ChEBI:CHEBI:11561, ChEBI:CHEBI:15378, CC ChEBI:CHEBI:15980, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349; CC EC=1.1.1.169; Evidence={ECO:0000256|ARBA:ARBA00000784}; CC -!- PATHWAY: Cofactor biosynthesis; (R)-pantothenate biosynthesis; (R)- CC pantoate from 3-methyl-2-oxobutanoate: step 2/2. CC {ECO:0000256|ARBA:ARBA00004994}. CC -!- SIMILARITY: Belongs to the ketopantoate reductase family. CC {ECO:0000256|ARBA:ARBA00007870}. CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ CC whole genome shotgun (WGS) entry which is preliminary data. CC {ECO:0000313|EMBL:KFG68294.1}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; JPUG01000068; KFG68294.1; -; Genomic_DNA. DR RefSeq; WP_036353154.1; NZ_JPUG01000068.1. DR STRING; 1549810.JH26_17185; -. DR EnsemblBacteria; KFG68294; KFG68294; JH26_17185. DR UniPathway; UPA00028; UER00004. DR Proteomes; UP000028825; Unassembled WGS sequence. DR GO; GO:0008677; F:2-dehydropantoate 2-reductase activity; IEA:UniProtKB-EC. DR GO; GO:0015940; P:pantothenate biosynthetic process; IEA:UniProtKB-UniPathway. DR Gene3D; 1.10.1040.10; -; 1. DR InterPro; IPR008927; 6-PGluconate_DH-like_C_sf. DR InterPro; IPR013328; 6PGD_dom2. DR InterPro; IPR013752; KPA_reductase. DR InterPro; IPR013332; KPR_N. DR InterPro; IPR036291; NAD(P)-bd_dom_sf. DR Pfam; PF02558; ApbA; 1. DR Pfam; PF08546; ApbA_C; 1. DR SUPFAM; SSF48179; SSF48179; 1. DR SUPFAM; SSF51735; SSF51735; 1. PE 3: Inferred from homology; KW Pantothenate biosynthesis {ECO:0000256|ARBA:ARBA00022655}; KW Reference proteome {ECO:0000313|Proteomes:UP000028825}. FT DOMAIN 6..151 FT /note="ApbA" FT /evidence="ECO:0000259|Pfam:PF02558" FT DOMAIN 179..321 FT /note="ApbA_C" FT /evidence="ECO:0000259|Pfam:PF08546" SQ SEQUENCE 338 AA; 36728 MW; A77CE1DA9EB4E9CD CRC64; MNENTILIWG AGAIGGTLGA YFARAGEDVL LVDLVEPHVE AMKRDGLFIE GPVETFRQPV QAAVPAEVTG QFKRIILAVK AHHTRDAVRA LKPHLAEDGT VLSAQNGLNE IIIAEEIGAE RTVGCFVNFG ADWLEPGRIL FGNRAAVAVG GLDGQATDIV RDYHRLLSIF EPRAVLTDNI WGYLWGKLGY GSLLFATALT NASMSENLAS ECHFPVYHLL GQEVMAVAKV RGVKPLGFNG FDPDAFMPGS DEAAARRSVA DMAEFNRHTA KTHSGIWRDL AVRKRKTEVD AQIAIIGTLG QEAGIPTPAI NKLVALIHDI EDGRREQSWS TLDEMLNL //