ID A0A086JNU3_TOXGO Unreviewed; 609 AA. AC A0A086JNU3; DT 29-OCT-2014, integrated into UniProtKB/TrEMBL. DT 29-OCT-2014, sequence version 1. DT 14-DEC-2022, entry version 28. DE SubName: Full=3'5'-cyclic nucleotide phosphodiesterase domain-containing protein {ECO:0000313|EMBL:KFG33811.1}; DE EC=3.1.4.17 {ECO:0000313|EMBL:KFG33811.1}; GN ORFNames=TGDOM2_258508 {ECO:0000313|EMBL:KFG33811.1}; OS Toxoplasma gondii GAB2-2007-GAL-DOM2. OC Eukaryota; Sar; Alveolata; Apicomplexa; Conoidasida; Coccidia; OC Eucoccidiorida; Eimeriorina; Sarcocystidae; Toxoplasma. OX NCBI_TaxID=1130820 {ECO:0000313|EMBL:KFG33811.1, ECO:0000313|Proteomes:UP000028837}; RN [1] {ECO:0000313|EMBL:KFG33811.1, ECO:0000313|Proteomes:UP000028837} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=GAB2-2007-GAL-DOM2 {ECO:0000313|EMBL:KFG33811.1, RC ECO:0000313|Proteomes:UP000028837}; RA Sibley D., Venepally P., Karamycheva S., Hadjithomas M., Khan A., Brunk B., RA Roos D., Caler E., Lorenzi H.; RL Submitted (FEB-2014) to the EMBL/GenBank/DDBJ databases. CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ CC whole genome shotgun (WGS) entry which is preliminary data. CC {ECO:0000313|EMBL:KFG33811.1}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AHZU02001301; KFG33811.1; -; Genomic_DNA. DR AlphaFoldDB; A0A086JNU3; -. DR EnsemblProtists; KFG33811; KFG33811; TGDOM2_258508. DR VEuPathDB; ToxoDB:TGDOM2_258508; -. DR Proteomes; UP000028837; Unassembled WGS sequence. DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW. DR GO; GO:0004114; F:3',5'-cyclic-nucleotide phosphodiesterase activity; IEA:UniProtKB-EC. DR GO; GO:0005216; F:ion channel activity; IEA:InterPro. DR GO; GO:0007165; P:signal transduction; IEA:InterPro. DR Gene3D; 1.10.1300.10; -; 1. DR Gene3D; 1.20.120.350; -; 1. DR InterPro; IPR005821; Ion_trans_dom. DR InterPro; IPR002073; PDEase_catalytic_dom. DR InterPro; IPR036971; PDEase_catalytic_dom_sf. DR InterPro; IPR027359; Volt_channel_dom_sf. DR Pfam; PF00520; Ion_trans; 1. DR Pfam; PF00233; PDEase_I; 1. DR PROSITE; PS51845; PDEASE_I_2; 1. PE 4: Predicted; KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000313|EMBL:KFG33811.1}; KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius}; KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989, KW ECO:0000256|SAM:Phobius}. FT TRANSMEM 48..73 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT DOMAIN 264..608 FT /note="PDEase" FT /evidence="ECO:0000259|PROSITE:PS51845" FT REGION 146..196 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 233..263 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 159..196 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" SQ SEQUENCE 609 AA; 68371 MW; 446ACC29FD6E172B CRC64; MHISCVKGRI VARQIDNVFT VIFAIEVLGK FVSYGLEYLQ DPIESFDTIV VLTSFTLLVL GFYVSGIGLL RILRLLSALA LLHKYPDSKE KRPELSAGNS SKLEKASSIV EGLLTNVHIP KYFKTELEWV WDSILANKVY DSHVVENEEE EEDQATETII AGSDASRKTQ AAVRASRAQS RASKLPHGSS SMVVGTTNGR ISGQILETLR EPDPRMMDAA LYKSETRNLD PLTATVGGMK NSPSMFAKGS KSSNMMGSSA SKSFRTERNK KAIDIISVLY QASQITGAEQ EQVNEAMRPF DEWQWDALHA GDVCDMNLLP VVFVRAIATF PTIMTKFNFD LDRLFDFLKV VQTSFQKNVK FHCAAHTADM IQAMHYFLTI GKLGALLSEY DVFLCHFCAL VCHFGHPGVT NTFLVKSRHP RAIRYDDESV NENYVASAIS CLVAREEYNF FGDKLPLWQV FRLHMIDILL NFDISKSAHQ VAMFRTKVSI KFTASTPADK QLLLTILLRA ADYSFTCRQL ALYSKWKDRM IDEFFAMGDT EKQLALTVSP FCDRELTNVD KCHVAFAEVA VKPLMTVLVL GLAPHLQKDV LDTLEANQKN LMQKLDKSD //