ID A0A081R422_STROR Unreviewed; 250 AA. AC A0A081R422; A0A0N5E9F1; D4FQD3; DT 29-OCT-2014, integrated into UniProtKB/TrEMBL. DT 29-OCT-2014, sequence version 1. DT 27-NOV-2024, entry version 49. DE SubName: Full=Accessory gene regulator protein A {ECO:0000313|EMBL:RSI72448.1}; DE SubName: Full=Response regulator transcription factor {ECO:0000313|EMBL:MCY7060819.1, ECO:0000313|EMBL:QQC34689.1}; DE SubName: Full=DNA-binding response regulator {ECO:0000313|EMBL:OJG02333.1}; DE SubName: Full=LytTr DNA-binding domain protein {ECO:0000313|EMBL:KEQ49945.1}; DE SubName: Full=Response regulator of the competence regulon ComE {ECO:0000313|EMBL:KXT81600.1}; GN Name=comE {ECO:0000313|EMBL:MCY7060819.1}; GN Synonyms=agrA {ECO:0000313|EMBL:RSI72448.1}; GN ORFNames=BBP19_05890 {ECO:0000313|EMBL:OJG02333.1}, D8804_06465 GN {ECO:0000313|EMBL:RSK08731.1}, D8858_05865 GN {ECO:0000313|EMBL:RSI75671.1}, D8860_01360 GN {ECO:0000313|EMBL:RSI72448.1}, I6H78_05400 GN {ECO:0000313|EMBL:QQC34689.1}, MK395_08395 GN {ECO:0000313|EMBL:MCY7060819.1}, SK143_1889 GN {ECO:0000313|EMBL:KEQ49945.1}, SORDD14_01205 GN {ECO:0000313|EMBL:KXT81600.1}, SORDD25_01487 GN {ECO:0000313|EMBL:KXU07563.1}, SORDD27_01772 GN {ECO:0000313|EMBL:KXT93693.1}, SORDD30_01523 GN {ECO:0000313|EMBL:KXT97486.1}; OS Streptococcus oralis. OC Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae; OC Streptococcus. OX NCBI_TaxID=1303 {ECO:0000313|EMBL:KEQ49945.1, ECO:0000313|Proteomes:UP000028098}; RN [1] {ECO:0000313|EMBL:KEQ49945.1, ECO:0000313|Proteomes:UP000028098} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=SK143 {ECO:0000313|EMBL:KEQ49945.1, RC ECO:0000313|Proteomes:UP000028098}; RA Daugherty S.C., Tallon L.J., Sadzewicz L., Kilian M., Tettelin H.; RL Submitted (MAY-2014) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Proteomes:UP000070220, ECO:0000313|Proteomes:UP000070497} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=DD14 {ECO:0000313|EMBL:KXT81600.1, RC ECO:0000313|Proteomes:UP000070497}, DD25 {ECO:0000313|EMBL:KXU07563.1, RC ECO:0000313|Proteomes:UP000071369}, DD27 {ECO:0000313|EMBL:KXT93693.1, RC ECO:0000313|Proteomes:UP000072363}, and DD30 RC {ECO:0000313|EMBL:KXT97486.1, ECO:0000313|Proteomes:UP000070220}; RA Denapaite D., Rieger M., Koendgen S., Brueckner R., Ochigava I., RA Kappeler P., Maetz-Rensing K., Leendertz F., Hakenbeck R.; RT "Highly variable Streptococcus oralis are common among viridans RT streptococci isolated from primates."; RL Submitted (JAN-2016) to the EMBL/GenBank/DDBJ databases. RN [3] {ECO:0000313|EMBL:OJG02333.1, ECO:0000313|Proteomes:UP000183671} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=SC15-3744 {ECO:0000313|EMBL:OJG02333.1, RC ECO:0000313|Proteomes:UP000183671}; RA Kanji J.N., Bharat A., Naidu P., Martin I., Mulvey M.R., Panaro C.D.; RT "A clinical isolate of carbapenem-resistant Streptococcus oralis with RT altered penicillin binding proteins."; RL Submitted (JUL-2016) to the EMBL/GenBank/DDBJ databases. RN [4] {ECO:0000313|Proteomes:UP000272687, ECO:0000313|Proteomes:UP000279863} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=BCA1 {ECO:0000313|EMBL:RSK08731.1, RC ECO:0000313|Proteomes:UP000279863}, BCC19 RC {ECO:0000313|EMBL:RSI75671.1, ECO:0000313|Proteomes:UP000281197}, and RC BCC50 {ECO:0000313|EMBL:RSI72448.1, RC ECO:0000313|Proteomes:UP000272687}; RA Velsko I.; RT "Species Designations Belie Phenotypic and Genotypic Heterogeneity in Oral RT Streptococci."; RL Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases. RN [5] {ECO:0000313|EMBL:QQC34689.1, ECO:0000313|Proteomes:UP000595948} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=FDAARGOS_1021 {ECO:0000313|EMBL:QQC34689.1, RC ECO:0000313|Proteomes:UP000595948}; RA Sproer C., Gronow S., Severitt S., Schroder I., Tallon L., Sadzewicz L., RA Zhao X., Boylan J., Ott S., Bowen H., Vavikolanu K., Mehta A., RA Aluvathingal J., Nadendla S., Lowell S., Myers T., Yan Y., Sichtig H.; RT "FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): RT Supporting development and validation of Infectious Disease Dx tests."; RL Submitted (DEC-2020) to the EMBL/GenBank/DDBJ databases. RN [6] {ECO:0000313|EMBL:MCY7060819.1, ECO:0000313|Proteomes:UP001207177} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=K16259064 {ECO:0000313|EMBL:MCY7060819.1, RC ECO:0000313|Proteomes:UP001207177}; RA Christensen J., Jensen C., Dargis R., Nielsen X., Pries- Heje M., RA Wiingaard C., Ihlemann N., Gill S., Bruun N., Elming H., Povlsen J., RA Madsen T., Jensen K., Fuursted K., Ostergaard L., Christiansen U., RA Rosenvinge F., Helweg-Larsen J., Fosbol E., Kober L., Torp-Pedersen C., RA Tonder N., Moser C., Iversen K., Bundgaard H.; RT "Genomic identification of streptococcal strains and relation to clinical RT characteristics. A substudy to The Partial Oral Treatment of Endocarditis RT (POET) Trial."; RL Med Res Arch 10:0-0(2022). RN [7] {ECO:0000313|EMBL:MCY7060819.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=K16259064 {ECO:0000313|EMBL:MCY7060819.1}; RA Christensen J.J.E., Jensen C.S., Nielsen X.C., Dargis R.; RL Submitted (FEB-2022) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Required for high-level post-exponential phase expression of CC a series of secreted proteins. {ECO:0000256|ARBA:ARBA00037164}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; JPGB01000006; KEQ49945.1; -; Genomic_DNA. DR EMBL; LQRI01000157; KXT81600.1; -; Genomic_DNA. DR EMBL; LQNZ01000144; KXT93693.1; -; Genomic_DNA. DR EMBL; LQRP01000048; KXT97486.1; -; Genomic_DNA. DR EMBL; LQZC01000011; KXU07563.1; -; Genomic_DNA. DR EMBL; JAKUVW010000004; MCY7060819.1; -; Genomic_DNA. DR EMBL; MBDM01000008; OJG02333.1; -; Genomic_DNA. DR EMBL; CP066059; QQC34689.1; -; Genomic_DNA. DR EMBL; RJNM01000001; RSI72448.1; -; Genomic_DNA. DR EMBL; RJNO01000012; RSI75671.1; -; Genomic_DNA. DR EMBL; RJVZ01000009; RSK08731.1; -; Genomic_DNA. DR RefSeq; WP_000866079.1; NZ_SSNB01000001.1. DR STRING; 1303.SORDD17_01792; -. DR GeneID; 49600697; -. DR PATRIC; fig|1303.44.peg.1811; -. DR Proteomes; UP000028098; Unassembled WGS sequence. DR Proteomes; UP000070220; Unassembled WGS sequence. DR Proteomes; UP000070497; Unassembled WGS sequence. DR Proteomes; UP000071369; Unassembled WGS sequence. DR Proteomes; UP000072363; Unassembled WGS sequence. DR Proteomes; UP000183671; Unassembled WGS sequence. DR Proteomes; UP000272687; Unassembled WGS sequence. DR Proteomes; UP000279863; Unassembled WGS sequence. DR Proteomes; UP000281197; Unassembled WGS sequence. DR Proteomes; UP000595948; Chromosome. DR Proteomes; UP001207177; Unassembled WGS sequence. DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW. DR GO; GO:0000156; F:phosphorelay response regulator activity; IEA:InterPro. DR CDD; cd17533; REC_LytTR_AgrA-like; 1. DR FunFam; 2.40.50.1020:FF:000003; DNA-binding response regulator; 1. DR Gene3D; 3.40.50.2300; -; 1. DR Gene3D; 2.40.50.1020; LytTr DNA-binding domain; 1. DR InterPro; IPR011006; CheY-like_superfamily. DR InterPro; IPR046947; LytR-like. DR InterPro; IPR007492; LytTR_DNA-bd_dom. DR InterPro; IPR001789; Sig_transdc_resp-reg_receiver. DR PANTHER; PTHR37299:SF3; STAGE 0 SPORULATION PROTEIN A HOMOLOG; 1. DR PANTHER; PTHR37299; TRANSCRIPTIONAL REGULATOR-RELATED; 1. DR Pfam; PF04397; LytTR; 1. DR Pfam; PF00072; Response_reg; 1. DR SMART; SM00850; LytTR; 1. DR SMART; SM00448; REC; 1. DR SUPFAM; SSF52172; CheY-like; 1. DR PROSITE; PS50930; HTH_LYTTR; 1. DR PROSITE; PS50110; RESPONSE_REGULATORY; 1. PE 4: Predicted; KW Activator {ECO:0000256|ARBA:ARBA00023159}; KW DNA-binding {ECO:0000313|EMBL:KEQ49945.1}; KW Phosphoprotein {ECO:0000256|PROSITE-ProRule:PRU00169}; KW Two-component regulatory system {ECO:0000256|ARBA:ARBA00023012}. FT DOMAIN 2..125 FT /note="Response regulatory" FT /evidence="ECO:0000259|PROSITE:PS50110" FT DOMAIN 142..246 FT /note="HTH LytTR-type" FT /evidence="ECO:0000259|PROSITE:PS50930" FT MOD_RES 58 FT /note="4-aspartylphosphate" FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00169" SQ SEQUENCE 250 AA; 29884 MW; 303E18B4B22EBE5B CRC64; MKVLILEDVI EHQVRLERIL NEISEESNIP ISYKTTGKVR EFKEYIENDE VNQLYFLDID IHGIEKKGFE VAQFIRHHNP YAIIVFITSR SEFATLTYKY QVSALDFVDK DINDELFKKR IEQSIFYTKS MLLENEDVVD YFDYNYKGND LKIPYHDILY IETTGVSHKL RIIGKNFAKE FYGTMTDIQE KDKHTQRFYC SHKSFLVNVG NVREIDRKNL EVVFYEDHRC PITRLKVRKL KDILEKKSKK //