ID A0A077S9M6_MOUSE Unreviewed; 163 AA. AC A0A077S9M6; DT 29-OCT-2014, integrated into UniProtKB/TrEMBL. DT 29-OCT-2014, sequence version 1. DT 12-AUG-2020, entry version 41. DE RecName: Full=Sperm acrosome membrane-associated protein 3 {ECO:0000256|ARBA:ARBA00016370}; DE AltName: Full=Sperm acrosome membrane-associated protein 3, membrane form {ECO:0000256|ARBA:ARBA00016830}; DE AltName: Full=Sperm acrosome membrane-associated protein 3, processed form {ECO:0000256|ARBA:ARBA00018371}; GN Name=Spaca3 {ECO:0000313|MGI:MGI:1922872}; GN Synonyms=Lyzc {ECO:0000313|EMBL:CDM98775.1}; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; OC Murinae; Mus; Mus. OX NCBI_TaxID=10090 {ECO:0000313|EMBL:CDM98775.1}; RN [1] {ECO:0000313|EMBL:CDM98775.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=N/A {ECO:0000313|EMBL:CDM98775.1}; RX PubMed=26484105; DOI=10.1016/j.gdata.2014.08.003; RA Premzl M.; RT "Third party annotation gene data set of eutherian lysozyme genes."; RL Genom Data 2:258-260(2014). RN [2] {ECO:0000313|EMBL:CDM98775.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=N/A {ECO:0000313|EMBL:CDM98775.1}; RX PubMed=26862561; DOI=10.1016/j.dib.2015.11.056; RA Premzl M.; RT "Curated eutherian third party data gene data sets."; RL Data Brief 6:208-213(2016). RN [3] {ECO:0000313|EMBL:CDM98775.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=N/A {ECO:0000313|EMBL:CDM98775.1}; RX DOI=10.1016/j.genrep.2019.100414; RA Premzl M.; RT "Eutherian third-party data gene collections."; RL Gene Rep 16:100414-100414(2019). CC -!- SUBUNIT: Interacts with ASTL. {ECO:0000256|ARBA:ARBA00011780}. CC -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle, secretory vesicle, acrosome CC membrane {ECO:0000256|ARBA:ARBA00004312}; Single-pass type II membrane CC protein {ECO:0000256|ARBA:ARBA00004312}. CC -!- SIMILARITY: Belongs to the glycosyl hydrolase 22 family. CC {ECO:0000256|ARBA:ARBA00010859, ECO:0000256|RuleBase:RU004440}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; HG931774; CDM98775.1; -; Genomic_DNA. DR RefSeq; NP_083643.1; NM_029367.1. DR RefSeq; XP_011247596.1; XM_011249294.2. DR SMR; A0A077S9M6; -. DR Antibodypedia; 15460; 58 antibodies. DR GeneID; 75622; -. DR KEGG; mmu:75622; -. DR CTD; 124912; -. DR MGI; MGI:1922872; Spaca3. DR HOGENOM; CLU_111620_0_1_1; -. DR KO; K13915; -. DR OMA; DWVDGCE; -. DR OrthoDB; 1551203at2759; -. DR BioGRID-ORCS; 75622; 1 hit in 18 CRISPR screens. DR Bgee; ENSMUSG00000053184; Expressed in spermatid and 33 other tissues. DR ExpressionAtlas; A0A077S9M6; baseline and differential. DR GO; GO:0043159; C:acrosomal matrix; IEA:Ensembl. DR GO; GO:0002080; C:acrosomal membrane; IEA:Ensembl. DR GO; GO:0003796; F:lysozyme activity; IEA:InterPro. DR GO; GO:0007342; P:fusion of sperm to egg plasma membrane involved in single fertilization; IEA:Ensembl. DR InterPro; IPR001916; Glyco_hydro_22. DR InterPro; IPR019799; Glyco_hydro_22_CS. DR InterPro; IPR000974; Glyco_hydro_22_lys. DR InterPro; IPR023346; Lysozyme-like_dom_sf. DR InterPro; IPR030058; LYZL3. DR PANTHER; PTHR11407:SF25; PTHR11407:SF25; 1. DR Pfam; PF00062; Lys; 1. DR PRINTS; PR00137; LYSOZYME. DR PRINTS; PR00135; LYZLACT. DR SMART; SM00263; LYZ1; 1. DR SUPFAM; SSF53955; SSF53955; 1. DR PROSITE; PS00128; GLYCOSYL_HYDROL_F22_1; 1. DR PROSITE; PS51348; GLYCOSYL_HYDROL_F22_2; 1. PE 3: Inferred from homology; KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157}; KW Signal {ECO:0000256|SAM:SignalP}; KW Signal-anchor {ECO:0000256|ARBA:ARBA00022968}; KW Transmembrane {ECO:0000256|ARBA:ARBA00022968}. FT SIGNAL 1..35 FT /evidence="ECO:0000256|SAM:SignalP" FT CHAIN 36..163 FT /note="Sperm acrosome membrane-associated protein 3" FT /evidence="ECO:0000256|SAM:SignalP" FT /id="PRO_5001723544" FT DOMAIN 110..128 FT /note="GLYCOSYL_HYDROL_F22_1" FT /evidence="ECO:0000259|PROSITE:PS00128" SQ SEQUENCE 163 AA; 18438 MW; 9FC152947A1B1A27 CRC64; MEARSRAPRR QLCPPGITWL ALAYLLSCLL ASSKAKVFSR CELAKEMHDF GLDGYRGYNL ADWVCLAYYT SGFNTNAVDH EADGSTNNGI FQISSRRWCR TLASNGPNLC RIYCTDLLNN DLKDSIVCAM KIVQEPLGLG YWEAWRHHCQ GRDLSDWVDG CDF //