ID A0A077MH38_9GEMI Unreviewed; 134 AA. AC A0A077MH38; DT 29-OCT-2014, integrated into UniProtKB/TrEMBL. DT 29-OCT-2014, sequence version 1. DT 11-MAY-2016, entry version 5. DE RecName: Full=Replication enhancer {ECO:0000256|RuleBase:RU363029}; DE Short=REn {ECO:0000256|RuleBase:RU363029}; GN Name=C3 {ECO:0000313|EMBL:CDF47516.1}; GN Synonyms=AC3 {ECO:0000313|EMBL:CDG50410.1}; OS Cotton leaf curl Burewala virus. OC Viruses; ssDNA viruses; Geminiviridae; Begomovirus; OC unclassified Begomovirus. OX NCBI_TaxID=620894 {ECO:0000313|EMBL:CDF47516.1}; RN [1] {ECO:0000313|EMBL:CDG50410.1} RP NUCLEOTIDE SEQUENCE. RA Norman P.J., Nemat-Gorgani N., Henn B.M., Parham P.; RT "KIR Polymorphism in Africans."; RL Submitted (JUL-2013) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|EMBL:CDF47516.1} RP NUCLEOTIDE SEQUENCE. RX DOI=10.4454/JPP.V96I1.045; RA Akhtar K.P., Ullah R., Saeed M., Sarwar N., Mansoor S.; RT "CHINA ROSE (HIBISCUS ROSA-SINENSIS): A NEW NATURAL HOST OF COTTON RT LEAF CURL BUREWALA VIRUS IN PAKISTAN."; RL J. Plant Pathol. 0:0-0(2014). CC -!- FUNCTION: Enhances infectivity and symptom expression. CC {ECO:0000256|RuleBase:RU363029}. CC -!- FUNCTION: Increases viral DNA accumulation. CC {ECO:0000256|RuleBase:RU363029}. CC -!- SUBUNIT: Homooligomer. Interacts with the replication-associated CC protein (REP). Interacts with host proliferating cell nuclear CC antigen (PCNA). Interacts with host retinoblastoma-related protein CC 1 (RBR1), and may thereby deregulate the host cell cycle. CC Oligomerization and interaction with PCNA are necessary for CC optimal replication enhancement. {ECO:0000256|RuleBase:RU363029}. CC -!- SIMILARITY: Belongs to the geminiviridae replication enhancer CC protein family. {ECO:0000256|RuleBase:RU363029}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; HG003876; CDF47516.1; -; Genomic_DNA. DR EMBL; HG422568; CDG50410.1; -; Genomic_DNA. DR EMBL; HG422569; CDG50416.1; -; Genomic_DNA. DR EMBL; HG422570; CDG50422.1; -; Genomic_DNA. DR EMBL; HG422574; CDG50442.1; -; Genomic_DNA. DR EMBL; HG422575; CDG50447.1; -; Genomic_DNA. DR GO; GO:0016032; P:viral process; IEA:UniProtKB-KW. DR InterPro; IPR000657; Gemini_AL3. DR Pfam; PF01407; Gemini_AL3; 1. DR PRINTS; PR00231; GEMCOATAL3. DR ProDom; PD001172; Gemini_AL3; 1. PE 3: Inferred from homology; KW Host-virus interaction {ECO:0000256|RuleBase:RU363029}. SQ SEQUENCE 134 AA; 15425 MW; 717BED360459C563 CRC64; MDSRTGEPIT AAQAGNGAYI WQVPNPLYFK IISHVNRPFT TNVDILTIRI QFNHNLRKAL GIHKCFIAFR IWMTSQPPTG RFLRVFRTQV LKYLSNLGIV SINNVVRAVD HVLWNVLQHV VFVDQSSSIK FNIY //