ID A0A075X0P7_HHV3 Unreviewed; 591 AA. AC A0A075X0P7; DT 29-OCT-2014, integrated into UniProtKB/TrEMBL. DT 29-OCT-2014, sequence version 1. DT 02-OCT-2024, entry version 23. DE SubName: Full=ORF14 {ECO:0000313|EMBL:AIH07051.1}; GN Name=ORF14 {ECO:0000313|EMBL:AIH07051.1}; OS Human herpesvirus 3 (HHV-3) (Varicella-zoster virus). OC Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes; OC Herpesvirales; Orthoherpesviridae; Alphaherpesvirinae; Varicellovirus; OC Varicellovirus humanalpha3. OX NCBI_TaxID=10335 {ECO:0000313|EMBL:AIH07051.1, ECO:0000313|Proteomes:UP000121874}; OH NCBI_TaxID=9606; Homo sapiens (Human). RN [1] {ECO:0000313|EMBL:AIH07051.1, ECO:0000313|Proteomes:UP000121874} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=YC01 {ECO:0000313|EMBL:AIH07051.1}; RA Kim J.I., Ji G.Y., Park H.S., Lee C.H.; RT "Molecular Analysis of Varicella-Zoster Viruses Isolated from Korean RT Patients."; RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|EMBL:ANS13256.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=YC01 {ECO:0000313|EMBL:ANS13256.1}; RX PubMed=27376245; DOI=10.1016/j.virol.2016.06.017; RA Jeon J.S., Won Y.H., Kim I.K., Ahn J.H., Shin O.S., Kim J.H., Lee C.H.; RT "Analysis of single nucleotide polymorphism among Varicella-Zoster Virus RT and identification of vaccine-specific sites."; RL Virology 496:277-286(2016). CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004167}; Single- CC pass membrane protein {ECO:0000256|ARBA:ARBA00004167}. Virion membrane CC {ECO:0000256|ARBA:ARBA00004381}; Single-pass membrane protein CC {ECO:0000256|ARBA:ARBA00004381}. CC -!- SIMILARITY: Belongs to the herpesviridae glycoprotein C family. CC {ECO:0000256|ARBA:ARBA00005284}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; KJ767491; AIH07051.1; -; Genomic_DNA. DR EMBL; KU926316; ANS13256.1; -; Genomic_DNA. DR Proteomes; UP000121874; Genome. DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell. DR GO; GO:0055036; C:virion membrane; IEA:UniProtKB-SubCell. DR GO; GO:0098671; P:adhesion receptor-mediated virion attachment to host cell; IEA:UniProtKB-KW. DR GO; GO:0046718; P:symbiont entry into host cell; IEA:UniProtKB-KW. DR GO; GO:0042784; P:symbiont-mediated suppression of host complement activation; IEA:UniProtKB-KW. DR GO; GO:0019049; P:virus-mediated perturbation of host defense response; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; Immunoglobulins; 1. DR InterPro; IPR001038; GA_GC. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR Pfam; PF02124; Marek_A; 1. DR PRINTS; PR00668; GLYCPROTEINC. DR SUPFAM; SSF48726; Immunoglobulin; 1. PE 3: Inferred from homology; KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157}; KW Host-virus interaction {ECO:0000256|ARBA:ARBA00023252}; KW Inhibition of host complement factors by virus KW {ECO:0000256|ARBA:ARBA00023252}; Membrane {ECO:0000256|SAM:Phobius}; KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}; KW Viral attachment to host adhesion receptor {ECO:0000256|ARBA:ARBA00023165}; KW Viral attachment to host cell {ECO:0000256|ARBA:ARBA00022804}; KW Viral immunoevasion {ECO:0000256|ARBA:ARBA00023280}; KW Virion {ECO:0000256|ARBA:ARBA00022844}; KW Virus entry into host cell {ECO:0000256|ARBA:ARBA00023296}. FT TRANSMEM 560..587 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT REGION 69..179 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" SQ SEQUENCE 591 AA; 64774 MW; 0C5D3AFEFD0D4BA0 CRC64; MSKKTFPSFK FRGGCFNLLF KGSVDVSIKT RMKRIQINLI LTIACIQLST ESQPTPVSIT ELYTSAATRN PDPAVAPTSA ATRKPDPAVA PTSAASRKPD PAVAPTSAAS RKPDPAVAPT SAATRNPDPA VAPTSAASRN PDPAVAPTSA ASRNPDPAVA PTSAATRKPD PAANAQHSQP PFLFENIQCV HGGIQSIPYF HTFIMPCYMR LTTGQQAAFK QQQKTYEQYS LDPEGSNITR WKSLIRPDLH IEVWFTRHLI DPHRQLGNAL IRMPDLPVML YSNSADLNLI NNPEIFTHAK ENYVIPDVKT TSDFSVTILS MDATTEGTYI WRVVNTKTKN VISEHSITVT TYYRPNITVV GDPVLTGQTY AAYCNVSKYY PPHSVRVRWT SRFGNIGKNF ITDAIQEYAN GLFSYVSAVR IPQQKQMDYP PPAIQCNVLW IRDGVSNMKY SAVVTPDVYP FPNVSIGIID GHIVCTAKCV PRGVVHFVWW VNDSPINHEN SEITGVCDQN KRFVNMQSSC PTSELDGPIT YSCHLDGYPK KFPPFSAVYT YDASTYATTF SVVAVIIGVI SILGTLGLIA VIATLCIRCC S //