ID A0A075QPB2_TOBAC Unreviewed; 84 AA. AC A0A075QPB2; DT 29-OCT-2014, integrated into UniProtKB/TrEMBL. DT 29-OCT-2014, sequence version 1. DT 27-NOV-2024, entry version 19. DE RecName: Full=eIF-4F 25 kDa subunit {ECO:0000256|ARBA:ARBA00032656}; DE AltName: Full=eIF-4F p26 subunit {ECO:0000256|ARBA:ARBA00041713}; DE AltName: Full=mRNA cap-binding protein {ECO:0000256|ARBA:ARBA00030245}; DE Flags: Fragment; OS Nicotiana tabacum (Common tobacco). OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; OC asterids; lamiids; Solanales; Solanaceae; Nicotianoideae; Nicotianeae; OC Nicotiana. OX NCBI_TaxID=4097 {ECO:0000313|EMBL:AIG20723.1}; RN [1] {ECO:0000313|EMBL:AIG20723.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=T025160 {ECO:0000313|EMBL:AIG20723.1}; RA Julio E., Cotucheau J., Decorps C., Volpatti R., Sentenac C., Candresse T., RA Dorlhac de Borne F.; RT "A Eukaryotic Translation Initiation Factor 4E (eIF4E) is Responsible for RT the 'va' Tobacco Recessive Resistance to Potyviruses."; RL Plant Mol. Biol. Rep. 33:609-623(2015). CC -!- FUNCTION: Component of the protein complex eIF4F, which is involved in CC the recognition of the mRNA cap, ATP-dependent unwinding of 5'-terminal CC secondary structure and recruitment of mRNA to the ribosome. Recognizes CC and binds the 7-methylguanosine-containing mRNA cap during an early CC step in the initiation of protein synthesis and facilitates ribosome CC binding by inducing the unwinding of the mRNAs secondary structures. CC Key component of recessive resistance to potyviruses. CC {ECO:0000256|ARBA:ARBA00045786}. CC -!- SUBUNIT: EIF4F is a multi-subunit complex, the composition of which CC varies with external and internal environmental conditions. It is CC composed of at least EIF4A, EIF4E and EIF4G. EIF4E is also known to CC interact with other partners. In higher plants two isoforms of EIF4F CC have been identified, named isoform EIF4F and isoform EIF(iso)4F. CC Isoform EIF4F has subunits p220 and p26, whereas isoform EIF(iso)4F has CC subunits p82 and p28. {ECO:0000256|ARBA:ARBA00025991}. CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}. CC Nucleus {ECO:0000256|ARBA:ARBA00004123}. CC -!- SIMILARITY: Belongs to the eukaryotic initiation factor 4E family. CC {ECO:0000256|ARBA:ARBA00009860, ECO:0000256|RuleBase:RU004374}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; KM202070; AIG20723.1; -; mRNA. DR AlphaFoldDB; A0A075QPB2; -. DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW. DR GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-KW. DR GO; GO:0006952; P:defense response; IEA:UniProtKB-KW. DR GO; GO:0009615; P:response to virus; IEA:UniProt. DR Gene3D; 3.30.760.10; RNA Cap, Translation Initiation Factor Eif4e; 1. DR InterPro; IPR023398; TIF_eIF4e-like. DR InterPro; IPR001040; TIF_eIF_4E. DR PANTHER; PTHR11960; EUKARYOTIC TRANSLATION INITIATION FACTOR 4E RELATED; 1. DR PANTHER; PTHR11960:SF43; EUKARYOTIC TRANSLATION INITIATION FACTOR 4E-1; 1. DR Pfam; PF01652; IF4E; 1. DR SUPFAM; SSF55418; eIF4e-like; 1. PE 2: Evidence at transcript level; KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490}; KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157}; KW Host-virus interaction {ECO:0000256|ARBA:ARBA00022581}; KW Initiation factor {ECO:0000256|ARBA:ARBA00022540, KW ECO:0000256|RuleBase:RU004374}; Nucleus {ECO:0000256|ARBA:ARBA00023242}; KW Plant defense {ECO:0000256|ARBA:ARBA00022821}; KW Protein biosynthesis {ECO:0000256|ARBA:ARBA00022917, KW ECO:0000256|RuleBase:RU004374}; KW RNA-binding {ECO:0000256|RuleBase:RU004374}; KW Translation regulation {ECO:0000256|ARBA:ARBA00022845}. FT NON_TER 84 FT /evidence="ECO:0000313|EMBL:AIG20723.1" SQ SEQUENCE 84 AA; 9267 MW; 83DB0647C3735BAA CRC64; MSFSKGKSDT SWLYTLLAMI GHQFDHGDEI CGAVVSVRAG RAKGEKIALW TKNAVNETAQ VSIGKQWKEF LDYSDSIGTF VKPL //