ID A0A075DMR2_9VIRU Unreviewed; 1778 AA. AC A0A075DMR2; DT 29-OCT-2014, integrated into UniProtKB/TrEMBL. DT 29-OCT-2014, sequence version 1. DT 11-NOV-2015, entry version 9. DE SubName: Full=Replicase {ECO:0000313|EMBL:AHM92766.1}; OS Prunus virus T. OC Viruses; ssRNA viruses; ssRNA positive-strand viruses, no DNA stage; OC Tymovirales; Betaflexiviridae; Tepovirus; unclassified Tepovirus. OX NCBI_TaxID=1472425 {ECO:0000313|EMBL:AHM92766.1}; RN [1] {ECO:0000313|EMBL:AHM92766.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=C21 {ECO:0000313|EMBL:AHM92766.1}; RX PubMed=25054616; RA Marais A., Faure C., Mustafayev E., Barone M., Alioto D., RA Candresse T.; RT "Characterization by deep sequencing of Prunus virus T, a novel RT Tepovirus infecting Prunus species."; RL Phytopathology 0:0-0(2014). CC -!- CATALYTIC ACTIVITY: Nucleoside triphosphate + RNA(n) = diphosphate CC + RNA(n+1). {ECO:0000256|SAAS:SAAS00153520}. CC -!- SIMILARITY: Contains (+)RNA virus helicase ATP-binding domain. CC {ECO:0000256|SAAS:SAAS00005295}. CC -!- SIMILARITY: Contains (+)RNA virus helicase C-terminal domain. CC {ECO:0000256|SAAS:SAAS00005240}. CC -!- SIMILARITY: Contains RdRp catalytic domain. CC {ECO:0000256|SAAS:SAAS00153546}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; KF700262; AHM92766.1; -; Genomic_RNA. DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW. DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW. DR GO; GO:0008174; F:mRNA methyltransferase activity; IEA:InterPro. DR GO; GO:0016491; F:oxidoreductase activity; IEA:InterPro. DR GO; GO:0003723; F:RNA binding; IEA:InterPro. DR GO; GO:0003968; F:RNA-directed RNA polymerase activity; IEA:UniProtKB-KW. DR GO; GO:0006396; P:RNA processing; IEA:InterPro. DR GO; GO:0006351; P:transcription, DNA-templated; IEA:InterPro. DR GO; GO:0039694; P:viral RNA genome replication; IEA:InterPro. DR Gene3D; 2.60.120.590; -; 1. DR Gene3D; 3.40.50.300; -; 2. DR InterPro; IPR027351; (+)RNA_virus_helicase_core_dom. DR InterPro; IPR027450; AlkB-like. DR InterPro; IPR002588; Alphavirus-like_MT_dom. DR InterPro; IPR005123; Oxoglu/Fe-dep_dioxygenase. DR InterPro; IPR027417; P-loop_NTPase. DR InterPro; IPR007094; RNA-dir_pol_PSvirus. DR InterPro; IPR001788; Tymovirus_RNA-dep_RNA_pol. DR Pfam; PF00978; RdRP_2; 1. DR Pfam; PF01443; Viral_helicase1; 1. DR Pfam; PF01660; Vmethyltransf; 1. DR SUPFAM; SSF52540; SSF52540; 2. DR PROSITE; PS51743; ALPHAVIRUS_MT; 1. DR PROSITE; PS51471; FE2OG_OXY; 1. DR PROSITE; PS51657; PSRV_HELICASE; 1. DR PROSITE; PS50507; RDRP_SSRNA_POS; 1. PE 4: Predicted; KW ATP-binding {ECO:0000256|SAAS:SAAS00180352}; KW Coiled coil {ECO:0000256|SAM:Coils}; KW Hydrolase {ECO:0000256|SAAS:SAAS00180363}; KW Nucleotide-binding {ECO:0000256|SAAS:SAAS00075875}; KW Nucleotidyltransferase {ECO:0000256|SAAS:SAAS00153703}; KW RNA-directed RNA polymerase {ECO:0000256|SAAS:SAAS00153521}; KW Transferase {ECO:0000256|SAAS:SAAS00153681}; KW Viral RNA replication {ECO:0000256|SAAS:SAAS00250960}. FT COILED 1428 1448 {ECO:0000256|SAM:Coils}. SQ SEQUENCE 1778 AA; 205830 MW; 0408E32C58AEBACE CRC64; MAFSYRTPAE EFLSTLPSTS QELVSKYAVK SLENQEKASS HNYSYHLTDT QKNFCSSVGV PLSVHNFMVH PHPYCKTMEN FILHDNLFHY RHLVSIYVSI KEEKVSLLNR SQGLNFHRVI NRCVADMDKL RYRNYVNRSF FENKNNFIPN QSKSWFFHDE LHHWTVNEMS DFLHNFKPER VLASCVLPVE VFSSDESCNP SFYKYQIHGR CRGVVEFTFY PDGSRESSYY QKSSDWIFKY KHFEIGGEIY TLSFLRSIKC HHLILIERGR LETNRFFISD SAECASLKMF GTAVAGKICA PIRVEVLKRE MIYLLSLKKS DMNSAAAKLR QLSQEDYHPQ ELCFFLNLAG RIESVKGIFK DRGLVSTIMD CFAKAFPNRL ARWMSNTIDE NSFLQLISSM EGMKLSVERV TFPVENFFEF NVKDGIDEQY ILDLMDEKFS GVGDPQPDTS YSVKVSRNKN YILTDFKAKK WERLADKESK EITTRVDIPG EMYEISLEEA RFFSGLVGKR NTMFHEIKEG EMDGIFFKRR DPIFLTNFEH WKLPVKKGIR EVTMKDAFQA EEQAEDMPPE EQFKPKEEER ADSCGSEEEE EELERHNEMD LSSDDEEECT FISGKFSPNE SFLDSLRMML NSKAAYPHGG RRTMLFSTVT GLDYGFGPHR YEQVKCDFME ELLKKTGFNS CLAQKYEEGG SIGPHFDDER VYDDDEILTW NVEGEADFVM LKREGTEIVH LTPGSVVLMP KGSSRGPEKF KHSVHGCTKG RVSITFRHQK RFMNGDPVEI ENYKRTQMEI PENLDEMIKK MSNACFLDCL ADHLAMNRNG VFNLLFDQDR SVLTNVVEDK GFTLAEVIDH LTNLDIPGRI VSSGEVINYL EKGSFKPIDL MMRDGHIGLN VQHQVLYNSK DIRVEDLIGA DVIKPNFSVE RARKLVKSMM EGLTGVVLNR FKYAFNELLP HHGNKVMCIA GFAGSGKSRA LQGVCSSVLN KKNVILSSPR KNLLRDWESK IGDKLKGKEM HIKLRTFELA VSAITRMVLK EGDVKLTVII DEVTLLPGGY IDLINSLIPE GSTIILLFDP LQSHYYSKMD VSANLGPVLT PIFGQEYRYR GYTYRFPELF KVEGFEFGKG EIDKNHMRIF AQPQAVREAV KKPVFLCPSE DKRNELSNFG EAYTFGTSQG LTFDFVCISL DMDGSVTSDF HWMVALTRAR KGFCFLTCAS TSLRNFKESN RAKLIGKVLN KEIISKKFWW NLGGRALDNA RCVDKDEFVK LGKTREEFEE ALGGDPWLKG LLNYLEGDDA KDPEPEEPVR KDSPPRTHLM LAPVEHQFAE EMHLLKAREF REFRNSNMWS DQFDDSRKTR KVIHNRAETF EQIYPSHKNS DTLTFWAAIK KRIKMSDPFS ERRKLERCMP IGENLCKIFI EEYGLKRGVI VDVESTEREF LLKRVEKAKK MIEAHSERSD PDWLVNHFFL FMKTQLCTKF EKRFSDAKAG QTLACFSHQV LARFGVPIRI AEKRLRSQLN DNIYIHSGKQ LDELNEWCIR YSQGYGTDSD YESFDRSQDA LVLAFEIHLL RFLGWNTDLI DDYVAIKLRL GCRLGYLAIM RFTGEFGTFF LNTCCNMLFT CLRYKINRRT PIAFAGDDMF SPGRLEVRRD REFLLNRFSL KAKVNFSKEP MFCGWRMTQY GIVKEPKLVL ERFKIAEERG CFKECLINYC LEVSFAYRLG ERLYEVIKNV QDQQALVRIV VKNKKFLPRK IRKEFESFDH EFGGSESVQE EGECDRVHRF GCGLECNL //