ID A0A075DMR2_9VIRU Unreviewed; 1778 AA. AC A0A075DMR2; DT 29-OCT-2014, integrated into UniProtKB/TrEMBL. DT 29-OCT-2014, sequence version 1. DT 07-OCT-2020, entry version 32. DE SubName: Full=Replicase {ECO:0000313|EMBL:AHM92766.1}; OS Prunus virus T. OC Viruses; Riboviria; Orthornavirae; Kitrinoviricota; Alsuviricetes; OC Tymovirales; Betaflexiviridae; Trivirinae; Tepovirus. OX NCBI_TaxID=1472425 {ECO:0000313|EMBL:AHM92766.1}; RN [1] {ECO:0000313|EMBL:AHM92766.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=C21 {ECO:0000313|EMBL:AHM92766.1}; RX PubMed=25054616; RA Marais A., Faure C., Mustafayev E., Barone M., Alioto D., Candresse T.; RT "Characterization by deep sequencing of Prunus virus T, a novel Tepovirus RT infecting Prunus species."; RL Phytopathology 0:0-0(2014). CC -!- CATALYTIC ACTIVITY: CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065, CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13; CC Evidence={ECO:0000256|ARBA:ARBA00001556}; CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; KF700262; AHM92766.1; -; Genomic_RNA. DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW. DR GO; GO:0008174; F:mRNA methyltransferase activity; IEA:UniProtKB-UniRule. DR GO; GO:0016491; F:oxidoreductase activity; IEA:InterPro. DR GO; GO:0003723; F:RNA binding; IEA:InterPro. DR GO; GO:0003724; F:RNA helicase activity; IEA:UniProtKB-EC. DR GO; GO:0003968; F:RNA-directed 5'-3' RNA polymerase activity; IEA:UniProtKB-KW. DR GO; GO:0006396; P:RNA processing; IEA:InterPro. DR GO; GO:0006351; P:transcription, DNA-templated; IEA:InterPro. DR GO; GO:0039694; P:viral RNA genome replication; IEA:InterPro. DR Gene3D; 2.60.120.590; -; 1. DR InterPro; IPR027351; (+)RNA_virus_helicase_core_dom. DR InterPro; IPR037151; AlkB-like_sf. DR InterPro; IPR002588; Alphavirus-like_MT_dom. DR InterPro; IPR043502; DNA/RNA_pol_sf. DR InterPro; IPR005123; Oxoglu/Fe-dep_dioxygenase. DR InterPro; IPR027417; P-loop_NTPase. DR InterPro; IPR007094; RNA-dir_pol_PSvirus. DR InterPro; IPR001788; Tymovirus_RNA-dep_RNA_pol. DR Pfam; PF00978; RdRP_2; 1. DR Pfam; PF01443; Viral_helicase1; 1. DR Pfam; PF01660; Vmethyltransf; 1. DR SUPFAM; SSF52540; SSF52540; 2. DR SUPFAM; SSF56672; SSF56672; 1. DR PROSITE; PS51743; ALPHAVIRUS_MT; 1. DR PROSITE; PS51471; FE2OG_OXY; 1. DR PROSITE; PS51657; PSRV_HELICASE; 1. DR PROSITE; PS50507; RDRP_SSRNA_POS; 1. PE 4: Predicted; KW ATP-binding {ECO:0000256|ARBA:ARBA00022840}; KW Coiled coil {ECO:0000256|SAM:Coils}; KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022840}; KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695}; KW RNA-directed RNA polymerase {ECO:0000256|ARBA:ARBA00022484}; KW Transferase {ECO:0000256|ARBA:ARBA00022679}; KW Viral RNA replication {ECO:0000256|ARBA:ARBA00022953}. FT DOMAIN 63..241 FT /note="Alphavirus-like MT" FT /evidence="ECO:0000259|PROSITE:PS51743" FT DOMAIN 677..770 FT /note="Fe2OG dioxygenase" FT /evidence="ECO:0000259|PROSITE:PS51471" FT DOMAIN 922..1238 FT /note="(+)RNA virus helicase C-terminal" FT /evidence="ECO:0000259|PROSITE:PS51657" FT DOMAIN 1534..1641 FT /note="RdRp catalytic" FT /evidence="ECO:0000259|PROSITE:PS50507" FT REGION 559..605 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COILED 1428..1448 FT /evidence="ECO:0000256|SAM:Coils" FT COMPBIAS 559..582 FT /note="Polyampholyte" FT /evidence="ECO:0000256|SAM:MobiDB-lite" SQ SEQUENCE 1778 AA; 205830 MW; 0408E32C58AEBACE CRC64; MAFSYRTPAE EFLSTLPSTS QELVSKYAVK SLENQEKASS HNYSYHLTDT QKNFCSSVGV PLSVHNFMVH PHPYCKTMEN FILHDNLFHY RHLVSIYVSI KEEKVSLLNR SQGLNFHRVI NRCVADMDKL RYRNYVNRSF FENKNNFIPN QSKSWFFHDE LHHWTVNEMS DFLHNFKPER VLASCVLPVE VFSSDESCNP SFYKYQIHGR CRGVVEFTFY PDGSRESSYY QKSSDWIFKY KHFEIGGEIY TLSFLRSIKC HHLILIERGR LETNRFFISD SAECASLKMF GTAVAGKICA PIRVEVLKRE MIYLLSLKKS DMNSAAAKLR QLSQEDYHPQ ELCFFLNLAG RIESVKGIFK DRGLVSTIMD CFAKAFPNRL ARWMSNTIDE NSFLQLISSM EGMKLSVERV TFPVENFFEF NVKDGIDEQY ILDLMDEKFS GVGDPQPDTS YSVKVSRNKN YILTDFKAKK WERLADKESK EITTRVDIPG EMYEISLEEA RFFSGLVGKR NTMFHEIKEG EMDGIFFKRR DPIFLTNFEH WKLPVKKGIR EVTMKDAFQA EEQAEDMPPE EQFKPKEEER ADSCGSEEEE EELERHNEMD LSSDDEEECT FISGKFSPNE SFLDSLRMML NSKAAYPHGG RRTMLFSTVT GLDYGFGPHR YEQVKCDFME ELLKKTGFNS CLAQKYEEGG SIGPHFDDER VYDDDEILTW NVEGEADFVM LKREGTEIVH LTPGSVVLMP KGSSRGPEKF KHSVHGCTKG RVSITFRHQK RFMNGDPVEI ENYKRTQMEI PENLDEMIKK MSNACFLDCL ADHLAMNRNG VFNLLFDQDR SVLTNVVEDK GFTLAEVIDH LTNLDIPGRI VSSGEVINYL EKGSFKPIDL MMRDGHIGLN VQHQVLYNSK DIRVEDLIGA DVIKPNFSVE RARKLVKSMM EGLTGVVLNR FKYAFNELLP HHGNKVMCIA GFAGSGKSRA LQGVCSSVLN KKNVILSSPR KNLLRDWESK IGDKLKGKEM HIKLRTFELA VSAITRMVLK EGDVKLTVII DEVTLLPGGY IDLINSLIPE GSTIILLFDP LQSHYYSKMD VSANLGPVLT PIFGQEYRYR GYTYRFPELF KVEGFEFGKG EIDKNHMRIF AQPQAVREAV KKPVFLCPSE DKRNELSNFG EAYTFGTSQG LTFDFVCISL DMDGSVTSDF HWMVALTRAR KGFCFLTCAS TSLRNFKESN RAKLIGKVLN KEIISKKFWW NLGGRALDNA RCVDKDEFVK LGKTREEFEE ALGGDPWLKG LLNYLEGDDA KDPEPEEPVR KDSPPRTHLM LAPVEHQFAE EMHLLKAREF REFRNSNMWS DQFDDSRKTR KVIHNRAETF EQIYPSHKNS DTLTFWAAIK KRIKMSDPFS ERRKLERCMP IGENLCKIFI EEYGLKRGVI VDVESTEREF LLKRVEKAKK MIEAHSERSD PDWLVNHFFL FMKTQLCTKF EKRFSDAKAG QTLACFSHQV LARFGVPIRI AEKRLRSQLN DNIYIHSGKQ LDELNEWCIR YSQGYGTDSD YESFDRSQDA LVLAFEIHLL RFLGWNTDLI DDYVAIKLRL GCRLGYLAIM RFTGEFGTFF LNTCCNMLFT CLRYKINRRT PIAFAGDDMF SPGRLEVRRD REFLLNRFSL KAKVNFSKEP MFCGWRMTQY GIVKEPKLVL ERFKIAEERG CFKECLINYC LEVSFAYRLG ERLYEVIKNV QDQQALVRIV VKNKKFLPRK IRKEFESFDH EFGGSESVQE EGECDRVHRF GCGLECNL //