ID   A0A075BI22_9INFA        Unreviewed;       757 AA.
AC   A0A075BI22;
DT   29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT   04-FEB-2015, sequence version 2.
DT   10-MAY-2017, entry version 17.
DE   RecName: Full=RNA-directed RNA polymerase catalytic subunit {ECO:0000256|RuleBase:RU004330, ECO:0000256|SAAS:SAAS00377010};
DE            EC=2.7.7.48 {ECO:0000256|RuleBase:RU004330, ECO:0000256|SAAS:SAAS00376969};
GN   Name=PB1 {ECO:0000313|EMBL:AGK23693.2};
OS   Influenza A virus (A/chicken/Shandong/11/2011(H9N2)).
OC   Viruses; ssRNA viruses; ssRNA negative-strand viruses;
OC   Orthomyxoviridae; Influenzavirus A.
OX   NCBI_TaxID=1309781 {ECO:0000313|EMBL:AGK23693.2, ECO:0000313|Proteomes:UP000134749};
RN   [1] {ECO:0000313|EMBL:AGK23693.2}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=A/chicken/Shandong/11/2011 {ECO:0000313|EMBL:AGK23693.2};
RX   PubMed=25548189; DOI=10.1073/pnas.1422456112;
RA   Pu J., Wang S., Yin Y., Zhang G., Carter R.A., Wang J., Xu G., Sun H.,
RA   Wang M., Wen C., Wei Y., Wang D., Zhu B., Lemmon G., Jiao Y., Duan S.,
RA   Wang Q., Du Q., Sun M., Bao J., Sun Y., Zhao J., Zhang H., Wu G.,
RA   Liu J., Webster R.G.;
RT   "Evolution of the H9N2 influenza genotype that facilitated the genesis
RT   of the novel H7N9 virus.";
RL   Proc. Natl. Acad. Sci. U.S.A. 112:548-553(2015).
CC   -!- CATALYTIC ACTIVITY: Nucleoside triphosphate + RNA(n) = diphosphate
CC       + RNA(n+1). {ECO:0000256|RuleBase:RU004330,
CC       ECO:0000256|SAAS:SAAS00605060}.
CC   -!- SIMILARITY: Belongs to the influenza viruses polymerase PB1
CC       family. {ECO:0000256|SAAS:SAAS00565435}.
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DR   EMBL; KC821097; AGK23693.2; -; Viral_cRNA.
DR   Proteomes; UP000134749; Genome.
DR   GO; GO:0000166; F:nucleotide binding; IEA:UniProtKB-KW.
DR   GO; GO:0003968; F:RNA-directed 5'-3' RNA polymerase activity; IEA:UniProtKB-KW.
DR   GO; GO:0006351; P:transcription, DNA-templated; IEA:InterPro.
DR   GO; GO:0039694; P:viral RNA genome replication; IEA:InterPro.
DR   InterPro; IPR007099; RNA-dir_pol_NSvirus.
DR   InterPro; IPR001407; RNA_pol_PB1_influenza.
DR   Pfam; PF00602; Flu_PB1; 1.
DR   PIRSF; PIRSF000827; RdRPol_OMV; 1.
DR   PROSITE; PS50525; RDRP_SSRNA_NEG_SEG; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000134749};
KW   Nucleotide-binding {ECO:0000256|SAAS:SAAS00605058};
KW   Nucleotidyltransferase {ECO:0000256|SAAS:SAAS00605055};
KW   RNA-directed RNA polymerase {ECO:0000256|RuleBase:RU004330,
KW   ECO:0000256|SAAS:SAAS00605053};
KW   Transferase {ECO:0000256|SAAS:SAAS00605061};
KW   Viral RNA replication {ECO:0000256|SAAS:SAAS00605045}.
FT   DOMAIN      286    483       RdRp catalytic. {ECO:0000259|PROSITE:
FT                                PS50525}.
SQ   SEQUENCE   757 AA;  86419 MW;  1A64564C300371F9 CRC64;
     MDVNPTLLFL KVPVQNAIST TFPYTGDPPY SHGTGTGYTM DTVNRTHKYS EKGKWTTNTE
     TGAPQLNPID GPLPEDNEPS GYAQTDCVLE AMAFLEESHP GIFENSCLET MEIVQQTRVD
     KLTQGRQTYD WTLNRNQPAA TALANTIEVF RSNGLTANES GRLIDFLKDV MDSMDKEEME
     VTTHFQRKRR VRDNMTKKMV TQRTIGKKKQ RLNKRSYLIR ALTLNTMTKD AERGKLKRRA
     IATPGMQIRG FVYFVEALAR SICEKLEQSG LPVGGNEKKA KLANVVRKMM TNSHDTELSF
     TITGDNTKWN ENQNPRMFLA MITYITRNQP EWFRNVLSIA PIMFSNKMAR LGKGYMFESK
     SMKLRTQVPA EMLANIDLKY FNKSTREKIE KIRPLLIDGT ASLSPGMMMG MFNMLSTVLG
     VSILNLGQKK YTKTTYWWDG LQSSDDFALI VNAPNHEGIQ AGVDRFYRTC KLVGINMSKK
     KSYINRTGTF EFTSFFYRYG FVANFSMELP SFGVSGINES ADMSIGVTVI KNNMINNDLG
     PATAQMALQL FIKDYRYTYR CHRGDTQIQT RRAFELKKLW EQTRSKAGLL VSDGGPNLYN
     IRNLHIPEVC LKWELMDEDY QGRLCNPMNP FVSHKEIDSV NNAVVMPAHG PAKNMEYDAV
     ATTHSWIPKR NRSILNTSQR GILEDEQMYQ KCCNLFEKFF PSSSYRRPVG ISSMVEAMVS
     RARIDARIDF ESGRIKKEEF AEIMKICSTI EELRRQK
//