ID A0A075BI22_9INFA Unreviewed; 757 AA. AC A0A075BI22; DT 29-OCT-2014, integrated into UniProtKB/TrEMBL. DT 04-FEB-2015, sequence version 2. DT 12-APR-2017, entry version 16. DE RecName: Full=RNA-directed RNA polymerase catalytic subunit {ECO:0000256|RuleBase:RU004330, ECO:0000256|SAAS:SAAS00377010}; DE EC=2.7.7.48 {ECO:0000256|RuleBase:RU004330, ECO:0000256|SAAS:SAAS00376969}; GN Name=PB1 {ECO:0000313|EMBL:AGK23693.2}; OS Influenza A virus (A/chicken/Shandong/11/2011(H9N2)). OC Viruses; ssRNA viruses; ssRNA negative-strand viruses; OC Orthomyxoviridae; Influenzavirus A. OX NCBI_TaxID=1309781 {ECO:0000313|EMBL:AGK23693.2, ECO:0000313|Proteomes:UP000134749}; RN [1] {ECO:0000313|EMBL:AGK23693.2} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=A/chicken/Shandong/11/2011 {ECO:0000313|EMBL:AGK23693.2}; RX PubMed=25548189; DOI=10.1073/pnas.1422456112; RA Pu J., Wang S., Yin Y., Zhang G., Carter R.A., Wang J., Xu G., Sun H., RA Wang M., Wen C., Wei Y., Wang D., Zhu B., Lemmon G., Jiao Y., Duan S., RA Wang Q., Du Q., Sun M., Bao J., Sun Y., Zhao J., Zhang H., Wu G., RA Liu J., Webster R.G.; RT "Evolution of the H9N2 influenza genotype that facilitated the genesis RT of the novel H7N9 virus."; RL Proc. Natl. Acad. Sci. U.S.A. 112:548-553(2015). CC -!- CATALYTIC ACTIVITY: Nucleoside triphosphate + RNA(n) = diphosphate CC + RNA(n+1). {ECO:0000256|RuleBase:RU004330, CC ECO:0000256|SAAS:SAAS00605060}. CC -!- SIMILARITY: Belongs to the influenza viruses polymerase PB1 CC family. {ECO:0000256|SAAS:SAAS00565435}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; KC821097; AGK23693.2; -; Viral_cRNA. DR Proteomes; UP000134749; Genome. DR GO; GO:0000166; F:nucleotide binding; IEA:UniProtKB-KW. DR GO; GO:0003968; F:RNA-directed 5'-3' RNA polymerase activity; IEA:UniProtKB-KW. DR GO; GO:0039523; P:suppression by virus of host RNA polymerase II activity; IEA:UniProtKB-KW. DR GO; GO:0006351; P:transcription, DNA-templated; IEA:InterPro. DR GO; GO:0039694; P:viral RNA genome replication; IEA:InterPro. DR GO; GO:0019083; P:viral transcription; IEA:UniProtKB-KW. DR InterPro; IPR007099; RNA-dir_pol_NSvirus. DR InterPro; IPR001407; RNA_pol_PB1_influenza. DR Pfam; PF00602; Flu_PB1; 1. DR PIRSF; PIRSF000827; RdRPol_OMV; 1. DR PROSITE; PS50525; RDRP_SSRNA_NEG_SEG; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000134749}; KW Nucleotide-binding {ECO:0000256|SAAS:SAAS00605058}; KW Nucleotidyltransferase {ECO:0000256|SAAS:SAAS00605055}; KW RNA-directed RNA polymerase {ECO:0000256|RuleBase:RU004330, KW ECO:0000256|SAAS:SAAS00605053}; KW Transferase {ECO:0000256|SAAS:SAAS00605061}; KW Viral RNA replication {ECO:0000256|SAAS:SAAS00605045}. FT DOMAIN 286 483 RdRp catalytic. {ECO:0000259|PROSITE: FT PS50525}. SQ SEQUENCE 757 AA; 86419 MW; 1A64564C300371F9 CRC64; MDVNPTLLFL KVPVQNAIST TFPYTGDPPY SHGTGTGYTM DTVNRTHKYS EKGKWTTNTE TGAPQLNPID GPLPEDNEPS GYAQTDCVLE AMAFLEESHP GIFENSCLET MEIVQQTRVD KLTQGRQTYD WTLNRNQPAA TALANTIEVF RSNGLTANES GRLIDFLKDV MDSMDKEEME VTTHFQRKRR VRDNMTKKMV TQRTIGKKKQ RLNKRSYLIR ALTLNTMTKD AERGKLKRRA IATPGMQIRG FVYFVEALAR SICEKLEQSG LPVGGNEKKA KLANVVRKMM TNSHDTELSF TITGDNTKWN ENQNPRMFLA MITYITRNQP EWFRNVLSIA PIMFSNKMAR LGKGYMFESK SMKLRTQVPA EMLANIDLKY FNKSTREKIE KIRPLLIDGT ASLSPGMMMG MFNMLSTVLG VSILNLGQKK YTKTTYWWDG LQSSDDFALI VNAPNHEGIQ AGVDRFYRTC KLVGINMSKK KSYINRTGTF EFTSFFYRYG FVANFSMELP SFGVSGINES ADMSIGVTVI KNNMINNDLG PATAQMALQL FIKDYRYTYR CHRGDTQIQT RRAFELKKLW EQTRSKAGLL VSDGGPNLYN IRNLHIPEVC LKWELMDEDY QGRLCNPMNP FVSHKEIDSV NNAVVMPAHG PAKNMEYDAV ATTHSWIPKR NRSILNTSQR GILEDEQMYQ KCCNLFEKFF PSSSYRRPVG ISSMVEAMVS RARIDARIDF ESGRIKKEEF AEIMKICSTI EELRRQK //