ID TVA23_HUMAN Reviewed; 121 AA. AC A0A075B6W5; DT 28-FEB-2018, integrated into UniProtKB/Swiss-Prot. DT 29-OCT-2014, sequence version 1. DT 24-JAN-2024, entry version 44. DE RecName: Full=T cell receptor alpha variable 23/delta variable 6 {ECO:0000303|Ref.2}; DE Flags: Precursor; GN Name=TRAV23DV6 {ECO:0000303|Ref.2}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] (IMGT ALLELE TRAV23/DV6*01). RX PubMed=12508121; DOI=10.1038/nature01348; RA Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C., RA Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A., RA Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H., RA Du H., Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T., RA Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B., RA Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D., RA Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R., RA Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S., RA Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C., RA Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S., RA Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C., RA Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P., RA Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M., RA Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V., RA Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J., RA Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F., RA Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F., RA Waterston R., Hood L., Weissenbach J.; RT "The DNA sequence and analysis of human chromosome 14."; RL Nature 421:601-607(2003). RN [2] RP NOMENCLATURE. RA Lefranc M.P., Lefranc G.; RT "The T Cell Receptor FactsBook."; RL (In) Lefranc M.P., Lefranc G. (eds.); RL The T Cell Receptor FactsBook., pp.1-397, Academic Press, London. (2001). RN [3] RP REVIEW ON T CELL REPERTOIRE DIVERSITY. RX PubMed=15040585; DOI=10.1038/nri1292; RA Nikolich-Zugich J., Slifka M.K., Messaoudi I.; RT "The many important facets of T-cell repertoire diversity."; RL Nat. Rev. Immunol. 4:123-132(2004). RN [4] RP REVIEW ON T CELL RECEPTOR-CD3 COMPLEX ASSEMBLY, AND SUBCELLULAR LOCATION. RX PubMed=20452950; DOI=10.1101/cshperspect.a005140; RA Wucherpfennig K.W., Gagnon E., Call M.J., Huseby E.S., Call M.E.; RT "Structural biology of the T-cell receptor: insights into receptor RT assembly, ligand recognition, and initiation of signaling."; RL Cold Spring Harb. Perspect. Biol. 2:A005140-A005140(2010). RN [5] RP REVIEW ON T CELL RECEPTOR SIGNALING. RX PubMed=23524462; DOI=10.1038/nri3403; RA Brownlie R.J., Zamoyska R.; RT "T cell receptor signalling networks: branched, diversified and bounded."; RL Nat. Rev. Immunol. 13:257-269(2013). RN [6] RP NOMENCLATURE. RX PubMed=24600447; DOI=10.3389/fimmu.2014.00022; RA Lefranc M.P.; RT "Immunoglobulin and T Cell Receptor Genes: IMGT((R)) and the Birth and Rise RT of Immunoinformatics."; RL Front. Immunol. 5:22-22(2014). RN [7] RP REVIEW ON FUNCTION. RX PubMed=25493333; DOI=10.1146/annurev-immunol-032414-112334; RA Rossjohn J., Gras S., Miles J.J., Turner S.J., Godfrey D.I., McCluskey J.; RT "T cell antigen receptor recognition of antigen-presenting molecules."; RL Annu. Rev. Immunol. 33:169-200(2015). CC -!- FUNCTION: V region of the variable domain of T cell receptor (TR) alpha CC chain that participates in the antigen recognition (PubMed:24600447). CC Alpha-beta T cell receptors are antigen specific receptors which are CC essential to the immune response and are present on the cell surface of CC T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) CC complexes that are displayed by antigen presenting cells (APC), a CC prerequisite for efficient T cell adaptive immunity against pathogens CC (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates CC TR-CD3 clustering on the cell surface and intracellular activation of CC LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 CC enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, CC which recruits numerous signaling molecules to form the LAT CC signalosome. The LAT signalosome propagates signal branching to three CC major signaling pathways, the calcium, the mitogen-activated protein CC kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) CC pathways, leading to the mobilization of transcription factors that are CC critical for gene expression and essential for T cell growth and CC differentiation (PubMed:23524462). The T cell repertoire is generated CC in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped CC by intrathymic selection events to generate a peripheral T cell pool of CC self-MH restricted, non-autoaggressive T cells. Post-thymic interaction CC of alpha-beta TR with the pMH complexes shapes TR structural and CC functional avidity (PubMed:15040585). {ECO:0000303|PubMed:15040585, CC ECO:0000303|PubMed:23524462, ECO:0000303|PubMed:24600447, CC ECO:0000303|PubMed:25493333}. CC -!- SUBUNIT: Alpha-beta TR is a heterodimer composed of an alpha and beta CC chain; disulfide-linked. The alpha-beta TR is associated with the CC transmembrane signaling CD3 coreceptor proteins to form the TR-CD3 (TcR CC or TCR). The assembly of alpha-beta TR heterodimers with CD3 occurs in CC the endoplasmic reticulum where a single alpha-beta TR heterodimer CC associates with one CD3D-CD3E heterodimer, one CD3G-CD3E heterodimer CC and one CD247 homodimer forming a stable octameric structure. CD3D-CD3E CC and CD3G-CD3E heterodimers preferentially associate with TR alpha and CC TR beta chains, respectively. The association of the CD247 homodimer is CC the last step of TcR assembly in the endoplasmic reticulum and is CC required for transport to the cell surface. CC {ECO:0000303|PubMed:20452950}. CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000303|PubMed:20452950}. CC -!- POLYMORPHISM: There are several alleles. The sequence shown is that of CC IMGT allele TRAV23/DV6*01. {ECO:0000305}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AC245505; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR AlphaFoldDB; A0A075B6W5; -. DR SMR; A0A075B6W5; -. DR IMGT_GENE-DB; TRAV23DV6; -. DR GlyCosmos; A0A075B6W5; 1 site, No reported glycans. DR GlyGen; A0A075B6W5; 1 site. DR BioMuta; TRAV23DV6; -. DR PeptideAtlas; A0A075B6W5; -. DR Ensembl; ENST00000390451.2; ENSP00000451203.1; ENSG00000211803.2. DR UCSC; uc058zed.1; human. DR AGR; HGNC:12120; -. DR GeneCards; TRAV23DV6; -. DR HGNC; HGNC:12120; TRAV23DV6. DR HPA; ENSG00000211803; Tissue enriched (lymphoid). DR neXtProt; NX_A0A075B6W5; -. DR OpenTargets; ENSG00000211803; -. DR VEuPathDB; HostDB:ENSG00000211803; -. DR GeneTree; ENSGT00940000153130; -. DR HOGENOM; CLU_077975_8_3_1; -. DR InParanoid; A0A075B6W5; -. DR OMA; YRKYPGE; -. DR PathwayCommons; A0A075B6W5; -. DR ChiTaRS; TRAV23DV6; human. DR Pharos; A0A075B6W5; Tdark. DR PRO; PR:A0A075B6W5; -. DR Proteomes; UP000005640; Chromosome 14. DR RNAct; A0A075B6W5; Protein. DR Bgee; ENSG00000211803; Expressed in granulocyte and 90 other cell types or tissues. DR GO; GO:0042101; C:T cell receptor complex; IEA:UniProtKB-KW. DR GO; GO:0042605; F:peptide antigen binding; IBA:GO_Central. DR GO; GO:0002250; P:adaptive immune response; IEA:UniProtKB-KW. DR CDD; cd04983; IgV_TCR_alpha; 1. DR Gene3D; 2.60.40.10; Immunoglobulins; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR013106; Ig_V-set. DR PANTHER; PTHR19343; T CELL RECEPTOR ALPHA VARIABLE 1-2; 1. DR PANTHER; PTHR19343:SF0; T CELL RECEPTOR ALPHA VARIABLE 23/DELTA VARIABLE 6; 1. DR Pfam; PF07686; V-set; 1. DR SMART; SM00406; IGv; 1. DR SUPFAM; SSF48726; Immunoglobulin; 1. DR PROSITE; PS50835; IG_LIKE; 1. PE 3: Inferred from homology; KW Adaptive immunity; Cell membrane; Disulfide bond; Glycoprotein; Immunity; KW Immunoglobulin domain; Membrane; Receptor; Reference proteome; Signal; KW T cell receptor. FT SIGNAL 1..21 FT /evidence="ECO:0000255" FT CHAIN 22..121 FT /note="T cell receptor alpha variable 23/delta variable 6" FT /evidence="ECO:0000255" FT /id="PRO_5001705209" FT DOMAIN 30..>121 FT /note="Ig-like" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114" FT CARBOHYD 95 FT /note="N-linked (GlcNAc...) asparagine" FT /evidence="ECO:0000255" FT DISULFID 51..118 FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114" FT NON_TER 121 SQ SEQUENCE 121 AA; 13545 MW; 9E59898F931CEFD1 CRC64; MDKILGASFL VLWLQLCWVS GQQKEKSDQQ QVKQSPQSLI VQKGGISIIN CAYENTAFDY FPWYQQFPGK GPALLIAIRP DVSEKKEGRF TISFNKSAKQ FSSHIMDSQP GDSATYFCAA S //