ID   A0A068X5X9_HYMMI        Unreviewed;      1277 AA.
AC   A0A068X5X9;
DT   01-OCT-2014, integrated into UniProtKB/TrEMBL.
DT   01-OCT-2014, sequence version 1.
DT   28-FEB-2018, entry version 19.
DE   SubName: Full=Isoleucyl tRNA synthetase cytoplasmic {ECO:0000313|EMBL:CDS27818.1};
GN   ORFNames=HmN_000177600 {ECO:0000313|EMBL:CDS27818.1};
OS   Hymenolepis microstoma (Rodent tapeworm) (Rodentolepis microstoma).
OC   Eukaryota; Metazoa; Platyhelminthes; Cestoda; Eucestoda;
OC   Cyclophyllidea; Hymenolepididae; Hymenolepis.
OX   NCBI_TaxID=85433 {ECO:0000313|EMBL:CDS27818.1, ECO:0000313|Proteomes:UP000017242};
RN   [1] {ECO:0000313|EMBL:CDS27818.1, ECO:0000313|Proteomes:UP000017242}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Nottingham {ECO:0000313|Proteomes:UP000017242};
RX   PubMed=23485966; DOI=10.1038/nature12031;
RA   Tsai I.J., Zarowiecki M., Holroyd N., Garciarrubio A.,
RA   Sanchez-Flores A., Brooks K.L., Tracey A., Bobes R.J., Fragoso G.,
RA   Sciutto E., Aslett M., Beasley H., Bennett H.M., Cai J., Camicia F.,
RA   Clark R., Cucher M., De Silva N., Day T.A., Deplazes P., Estrada K.,
RA   Fernandez C., Holland P.W., Hou J., Hu S., Huckvale T., Hung S.S.,
RA   Kamenetzky L., Keane J.A., Kiss F., Koziol U., Lambert O., Liu K.,
RA   Luo X., Luo Y., Macchiaroli N., Nichol S., Paps J., Parkinson J.,
RA   Pouchkina-Stantcheva N., Riddiford N., Rosenzvit M., Salinas G.,
RA   Wasmuth J.D., Zamanian M., Zheng Y., Taenia solium Genome Consortium,
RA   Cai X., Olson P.D., Laclette J.P., Brehm K., Berriman M.;
RT   "The genomes of four tapeworm species reveal adaptations to
RT   parasitism.";
RL   Nature 496:57-63(2013).
CC   -!- SIMILARITY: Belongs to the class-I aminoacyl-tRNA synthetase
CC       family. {ECO:0000256|RuleBase:RU363035}.
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DR   EMBL; LN906338; CDS27818.1; -; Genomic_DNA.
DR   GeneDB; HmN_000177600.1:pep; -.
DR   Proteomes; UP000017242; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR   GO; GO:0002161; F:aminoacyl-tRNA editing activity; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004822; F:isoleucine-tRNA ligase activity; IEA:InterPro.
DR   GO; GO:0000049; F:tRNA binding; IEA:InterPro.
DR   GO; GO:0006428; P:isoleucyl-tRNA aminoacylation; IEA:InterPro.
DR   CDD; cd07961; Anticodon_Ia_Ile_ABEc; 1.
DR   Gene3D; 3.40.50.620; -; 2.
DR   Gene3D; 3.90.740.10; -; 1.
DR   InterPro; IPR001412; aa-tRNA-synth_I_CS.
DR   InterPro; IPR002300; aa-tRNA-synth_Ia.
DR   InterPro; IPR033709; Anticodon_Ile_ABEc.
DR   InterPro; IPR002301; Ile-tRNA-ligase.
DR   InterPro; IPR013155; M/V/L/I-tRNA-synth_anticd-bd.
DR   InterPro; IPR014729; Rossmann-like_a/b/a_fold.
DR   InterPro; IPR009080; tRNAsynth_Ia_anticodon-bd.
DR   InterPro; IPR009008; Val/Leu/Ile-tRNA-synth_edit.
DR   Pfam; PF08264; Anticodon_1; 1.
DR   Pfam; PF00133; tRNA-synt_1; 1.
DR   PRINTS; PR00984; TRNASYNTHILE.
DR   SUPFAM; SSF47323; SSF47323; 2.
DR   SUPFAM; SSF50677; SSF50677; 1.
DR   TIGRFAMs; TIGR00392; ileS; 1.
DR   PROSITE; PS00178; AA_TRNA_LIGASE_I; 1.
PE   3: Inferred from homology;
KW   Aminoacyl-tRNA synthetase {ECO:0000256|RuleBase:RU363035,
KW   ECO:0000313|EMBL:CDS27818.1};
KW   ATP-binding {ECO:0000256|RuleBase:RU363035};
KW   Complete proteome {ECO:0000313|Proteomes:UP000017242};
KW   Ligase {ECO:0000256|RuleBase:RU363035};
KW   Nucleotide-binding {ECO:0000256|RuleBase:RU363035};
KW   Protein biosynthesis {ECO:0000256|RuleBase:RU363035};
KW   Reference proteome {ECO:0000313|Proteomes:UP000017242}.
FT   DOMAIN       19    642       tRNA-synt_1. {ECO:0000259|Pfam:PF00133}.
FT   DOMAIN      698    879       Anticodon_1. {ECO:0000259|Pfam:PF08264}.
SQ   SEQUENCE   1277 AA;  144681 MW;  250244BBA9010774 CRC64;
     MDRDDLPPSI NFPEEEEKIL KFHNEIDAFN TSNTLSSKRP LFSFYDGPPF ATGLPHYGHI
     LAGTIKDVVT RFAYSEGYHV HRNFGWDCHG LPVEYEVDKT HDIKGPADVA AIGVAAYNDK
     CREIVMRYSS QWRDVVLRLG RWIDFEKDYR TMYPSFMESV WWVFSELFEK GLVYRGVKVM
     PFSTACATPL SNFEAGQNYK DVQDPAIVVA FSVDDSEENL ELLAWTTTPW TLPSNLALCV
     NPEKDYVKVK DKTRNNRVFA LMECRLTWFF KKPEDYEVLD KMKGDKLIGL KYKPLFDYFI
     EMKESRGAFR VLGDSYVTEE TGTGIVHQAP YFGEDDYRIC LREGVVTREM PPICPVDASG
     QFTSEVSDFV GQYVKDADRN ICQHLKHAGR LLQQSTIQHS YPFCWRSDTP LLYKAVPTWF
     IRVECLVDRL LANNAKTSWV PDFIKEKRFA NWLRDARDWA ISRNRYWGTP IPLWVSDDME
     EVVCVGSIEE LERLSGVRVT DLHKEFVDPI TIPSKMGKGD LKRVSEVFDC WFESGSMPYA
     QIHYPFENTE RFKKGFPADF VAEGVDQTRG WFYTLLVLST ALFDQPPFKN LIVNGIVLAS
     DGQKMSKRQK NYPDPRGVID RYGADALRLY LINSPVVRAQ NLRFFESGVR DVLKDVLIPW
     YNAFRFLMKS GIEPWERAHK KSFIVPVEIW PKSRNLMDRW VLSFTLTLLR FVHTELQAYR
     LYTVVPRLLR FIEYLVNWYI RMNRRRLKGE SMEDEEDWFA ALHTLVKVLT QLIFMMAPFA
     PFFTEFIFQR LKTKLDFSNF KIENIGEVPS AVDENGAPVS LHYLINLWYP AELEKVNTVT
     ADVVDSALEA RVAFMQAAVE AGRSIRTRLE LPLKAPLRSA VLIHPPDTDV VDALGKDGSD
     GLANYVREEL NVRQLTVTSD KAAYGVRLRA RLNPATAGPR LRGAFKPISN ALSNLSQSAL
     EQYVLKGEMT LEDELLSGDD VTIDYVVGDA HESNSSEGNP LLKAAKGKLK KTGRLATTSP
     VEPKEKPADG PHWEAQAWDV SDGLGRILVL LDVRPDAELV EERLARELIN RIQRARKKGN
     LLPEDTIQVV ISTTSESLRK ALSTHAMLID ATVKQPIACC ADANDDSGAL KTAQLDAEAR
     GERLGELVVS EVTTIPPDDL SVTIFHRLTK CSNSKSPASQ NQVKAKSDSS PNSAECGSQS
     PTVKVRCSKT GESIDVHLVD ARGNRLVSDV VELLNVVRGA FGWVKTAEMR LVRCGSVVKC
     SSTENILGFS GLELNLE
//