ID A0A068EV73_9TELE Unreviewed; 348 AA. AC A0A068EV73; DT 01-OCT-2014, integrated into UniProtKB/TrEMBL. DT 01-OCT-2014, sequence version 1. DT 16-JAN-2019, entry version 17. DE RecName: Full=NADH-ubiquinone oxidoreductase chain 2 {ECO:0000256|RuleBase:RU003403, ECO:0000256|SAAS:SAAS00387861}; DE EC=7.1.1.2 {ECO:0000256|RuleBase:RU003403, ECO:0000256|SAAS:SAAS01109717}; GN Name=ND2 {ECO:0000313|EMBL:AID52436.1}; OS Rhynchocypris lagowskii (Amur minnow). OG Mitochondrion {ECO:0000313|EMBL:AID52436.1}. OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; OC Cyprinidae; Rhynchocypris. OX NCBI_TaxID=219677 {ECO:0000313|EMBL:AID52436.1}; RN [1] {ECO:0000313|EMBL:AID52436.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=24865913; RA Sun Q., Wang D., Wei Q.; RT "The complete mitochondrial gemone of Phoxinus lagowskii (Teleostei, RT Cypriniformes: Cyprinidae)."; RL Mitochondrial DNA 0:0-0(2014). CC -!- FUNCTION: Core subunit of the mitochondrial membrane respiratory CC chain NADH dehydrogenase (Complex I) that is believed to belong to CC the minimal assembly required for catalysis. Complex I functions CC in the transfer of electrons from NADH to the respiratory chain. CC The immediate electron acceptor for the enzyme is believed to be CC ubiquinone. {ECO:0000256|RuleBase:RU003403, CC ECO:0000256|SAAS:SAAS00093760}. CC -!- CATALYTIC ACTIVITY: CC Reaction=a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 CC H(+)(out) + NAD(+); Xref=Rhea:RHEA:29091, Rhea:RHEA-COMP:9565, CC Rhea:RHEA-COMP:9566, ChEBI:CHEBI:15378, ChEBI:CHEBI:16389, CC ChEBI:CHEBI:17976, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; CC EC=7.1.1.2; Evidence={ECO:0000256|RuleBase:RU003403, CC ECO:0000256|SAAS:SAAS01125045}; CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane CC {ECO:0000256|RuleBase:RU003403, ECO:0000256|SAAS:SAAS00093751}; CC Multi-pass membrane protein {ECO:0000256|RuleBase:RU003403, CC ECO:0000256|SAAS:SAAS00093751}. CC -!- SIMILARITY: Belongs to the complex I subunit 2 family. CC {ECO:0000256|RuleBase:RU003403, ECO:0000256|SAAS:SAAS00573211}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; KJ641843; AID52436.1; -; Genomic_DNA. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell. DR GO; GO:0070469; C:respirasome; IEA:UniProtKB-KW. DR GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; IEA:UniProtKB-EC. DR GO; GO:0006120; P:mitochondrial electron transport, NADH to ubiquinone; IEA:InterPro. DR InterPro; IPR010933; NADH_DH_su2_C. DR InterPro; IPR003917; NADH_UbQ_OxRdtase_chain2. DR InterPro; IPR001750; ND/Mrp_mem. DR Pfam; PF06444; NADH_dehy_S2_C; 1. DR Pfam; PF00361; Proton_antipo_M; 1. DR PRINTS; PR01436; NADHDHGNASE2. PE 3: Inferred from homology; KW Electron transport {ECO:0000256|RuleBase:RU003403, KW ECO:0000256|SAAS:SAAS00464461}; KW Membrane {ECO:0000256|RuleBase:RU003403, KW ECO:0000256|SAAS:SAAS00093718}; KW Mitochondrion {ECO:0000256|RuleBase:RU003403, KW ECO:0000256|SAAS:SAAS00464403, ECO:0000313|EMBL:AID52436.1}; KW Mitochondrion inner membrane {ECO:0000256|RuleBase:RU003403, KW ECO:0000256|SAAS:SAAS00464436}; KW NAD {ECO:0000256|RuleBase:RU003403, ECO:0000256|SAAS:SAAS00093707}; KW Respiratory chain {ECO:0000256|RuleBase:RU003403, KW ECO:0000256|SAAS:SAAS00093685}; KW Translocase {ECO:0000256|RuleBase:RU003403, KW ECO:0000256|SAAS:SAAS01109684}; KW Transmembrane {ECO:0000256|RuleBase:RU003403, KW ECO:0000256|SAAS:SAAS00093696}; KW Transmembrane helix {ECO:0000256|RuleBase:RU003403, KW ECO:0000256|SAAS:SAAS00464584}; KW Transport {ECO:0000256|SAAS:SAAS00093687}; KW Ubiquinone {ECO:0000256|RuleBase:RU003403, KW ECO:0000256|SAAS:SAAS00093675}. FT TRANSMEM 57 80 Helical. {ECO:0000256|RuleBase:RU003403}. FT TRANSMEM 92 113 Helical. {ECO:0000256|RuleBase:RU003403}. FT TRANSMEM 152 171 Helical. {ECO:0000256|RuleBase:RU003403}. FT TRANSMEM 178 196 Helical. {ECO:0000256|RuleBase:RU003403}. FT TRANSMEM 202 219 Helical. {ECO:0000256|RuleBase:RU003403}. FT TRANSMEM 274 294 Helical. {ECO:0000256|RuleBase:RU003403}. FT TRANSMEM 326 347 Helical. {ECO:0000256|RuleBase:RU003403}. FT DOMAIN 23 287 Proton_antipo_M. {ECO:0000259|Pfam: FT PF00361}. FT DOMAIN 290 344 NADH_dehy_S2_C. {ECO:0000259|Pfam: FT PF06444}. SQ SEQUENCE 348 AA; 37567 MW; 24A160198FCD9AA8 CRC64; MNPYVLMTLL SSLGLGTTLT FASSHWLLAW MGLEINTLAI VPLMAQHHHP RAVEATTKYF LVQATAAAMI LFASTTNAWI TGQWDINGID SPIATTMVMA ALALKIGLAP MHLWMPEVLQ GLDLLTGLVL STWQKLAPLA LIIQAAQAID PFTLTAFGLA SALVGGWGGL NQTQLRKILA YSSIAHMGWM IIVLQYAPQL TLLALITYIF MTSAAFLALK ASSATKISTI AVVWSKSPTL TMTTALVLLS LGGLPPLTGF MPKWFIMQEL ATQNLPLTAT IMALAALLSL YFYLRLCYAM TLTISPNTFN STTPWRVQAA QTSLPLALST LMALALLPMA PTIMMLIT //