ID   A0A068EV73_9TELE        Unreviewed;       348 AA.
AC   A0A068EV73;
DT   01-OCT-2014, integrated into UniProtKB/TrEMBL.
DT   01-OCT-2014, sequence version 1.
DT   16-MAR-2016, entry version 12.
DE   RecName: Full=NADH-ubiquinone oxidoreductase chain 2 {ECO:0000256|RuleBase:RU003403, ECO:0000256|SAAS:SAAS00093744};
DE            EC=1.6.5.3 {ECO:0000256|RuleBase:RU003403, ECO:0000256|SAAS:SAAS00093728};
GN   Name=ND2 {ECO:0000313|EMBL:AID52436.1};
OS   Rhynchocypris lagowskii (Amur minnow).
OG   Mitochondrion {ECO:0000313|EMBL:AID52436.1}.
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Cyprinidae; Rhynchocypris.
OX   NCBI_TaxID=219677 {ECO:0000313|EMBL:AID52436.1};
RN   [1] {ECO:0000313|EMBL:AID52436.1}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=24865913;
RA   Sun Q., Wang D., Wei Q.;
RT   "The complete mitochondrial gemone of Phoxinus lagowskii (Teleostei,
RT   Cypriniformes: Cyprinidae).";
RL   Mitochondrial DNA 0:0-0(2014).
CC   -!- FUNCTION: Core subunit of the mitochondrial membrane respiratory
CC       chain NADH dehydrogenase (Complex I) that is believed to belong to
CC       the minimal assembly required for catalysis. Complex I functions
CC       in the transfer of electrons from NADH to the respiratory chain.
CC       The immediate electron acceptor for the enzyme is believed to be
CC       ubiquinone (By similarity). {ECO:0000256|SAAS:SAAS00207298}.
CC   -!- CATALYTIC ACTIVITY: NADH + ubiquinone + 5 H(+)(In) = NAD(+) +
CC       ubiquinol + 4 H(+)(Out). {ECO:0000256|RuleBase:RU003403,
CC       ECO:0000256|SAAS:SAAS00093735}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC       {ECO:0000256|RuleBase:RU003403, ECO:0000256|SAAS:SAAS00093751};
CC       Multi-pass membrane protein {ECO:0000256|RuleBase:RU003403,
CC       ECO:0000256|SAAS:SAAS00093751}.
CC   -!- SIMILARITY: Belongs to the complex I subunit 2 family.
CC       {ECO:0000256|RuleBase:RU003403}.
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DR   EMBL; KJ641843; AID52436.1; -; Genomic_DNA.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0070469; C:respiratory chain; IEA:UniProtKB-KW.
DR   GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; IEA:UniProtKB-EC.
DR   GO; GO:0006120; P:mitochondrial electron transport, NADH to ubiquinone; IEA:InterPro.
DR   InterPro; IPR010933; NADH_DH_su2_C.
DR   InterPro; IPR003917; NADH_UbQ_OxRdtase_chain2.
DR   InterPro; IPR001750; ND/Mrp_mem.
DR   Pfam; PF06444; NADH_dehy_S2_C; 1.
DR   Pfam; PF00361; Proton_antipo_M; 1.
DR   PRINTS; PR01436; NADHDHGNASE2.
PE   3: Inferred from homology;
KW   Electron transport {ECO:0000256|SAAS:SAAS00464461};
KW   Membrane {ECO:0000256|SAAS:SAAS00464716, ECO:0000256|SAM:Phobius};
KW   Mitochondrion {ECO:0000256|RuleBase:RU000318,
KW   ECO:0000256|SAAS:SAAS00464403, ECO:0000313|EMBL:AID52436.1};
KW   Mitochondrion inner membrane {ECO:0000256|SAAS:SAAS00464436};
KW   NAD {ECO:0000256|RuleBase:RU000317, ECO:0000256|SAAS:SAAS00464384};
KW   Oxidoreductase {ECO:0000256|RuleBase:RU000317,
KW   ECO:0000256|SAAS:SAAS00464503};
KW   Respiratory chain {ECO:0000256|SAAS:SAAS00464594};
KW   Transmembrane {ECO:0000256|SAAS:SAAS00464491,
KW   ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00464584,
KW   ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|SAAS:SAAS00464711};
KW   Ubiquinone {ECO:0000256|RuleBase:RU000318,
KW   ECO:0000256|SAAS:SAAS00464648}.
FT   TRANSMEM     57     80       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM     92    113       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    152    171       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    178    196       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    202    219       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    274    294       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    326    347       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       23    287       Proton_antipo_M. {ECO:0000259|Pfam:
FT                                PF00361}.
FT   DOMAIN      290    344       NADH_dehy_S2_C. {ECO:0000259|Pfam:
FT                                PF06444}.
SQ   SEQUENCE   348 AA;  37567 MW;  24A160198FCD9AA8 CRC64;
     MNPYVLMTLL SSLGLGTTLT FASSHWLLAW MGLEINTLAI VPLMAQHHHP RAVEATTKYF
     LVQATAAAMI LFASTTNAWI TGQWDINGID SPIATTMVMA ALALKIGLAP MHLWMPEVLQ
     GLDLLTGLVL STWQKLAPLA LIIQAAQAID PFTLTAFGLA SALVGGWGGL NQTQLRKILA
     YSSIAHMGWM IIVLQYAPQL TLLALITYIF MTSAAFLALK ASSATKISTI AVVWSKSPTL
     TMTTALVLLS LGGLPPLTGF MPKWFIMQEL ATQNLPLTAT IMALAALLSL YFYLRLCYAM
     TLTISPNTFN STTPWRVQAA QTSLPLALST LMALALLPMA PTIMMLIT
//