ID A0A068BA71_9NEOP Unreviewed; 265 AA. AC A0A068BA71; DT 01-OCT-2014, integrated into UniProtKB/TrEMBL. DT 01-OCT-2014, sequence version 1. DT 08-JUN-2016, entry version 9. DE RecName: Full=Cytochrome c oxidase subunit 1 {ECO:0000256|RuleBase:RU000369}; DE EC=1.9.3.1 {ECO:0000256|RuleBase:RU000369}; DE Flags: Fragment; OS Micrarchus sp. n. 2 LTD-2014. OG Mitochondrion {ECO:0000313|EMBL:AIC79428.1}. OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; OC Pterygota; Neoptera; Orthopteroidea; Phasmatodea; Verophasmatodea; OC Anareolatae; Diapheromeridae; Pachymorphinae; Micrarchus. OX NCBI_TaxID=1448259 {ECO:0000313|EMBL:AIC79428.1}; RN [1] {ECO:0000313|EMBL:AIC79428.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=MMT004 {ECO:0000313|EMBL:AIC79388.1}, MMT027 RC {ECO:0000313|EMBL:AIC79424.1}, MMT028 {ECO:0000313|EMBL:AIC79426.1}, RC MMT029 {ECO:0000313|EMBL:AIC79428.1}, MMT032 RC {ECO:0000313|EMBL:AIC79434.1}, and MMT056 RC {ECO:0000313|EMBL:AIC79478.1}; RX PubMed=24762129; DOI=10.1111/mec.12767; RA Dunning L.T., Dennis A.B., Sinclair B.J., Newcomb R.D., Buckley T.R.; RT "Divergent transcriptional responses to low temperature among RT populations of alpine and lowland species of New Zealand stick insects RT (Micrarchus)."; RL Mol. Ecol. 23:2712-2726(2014). CC -!- FUNCTION: Cytochrome c oxidase is the component of the respiratory CC chain that catalyzes the reduction of oxygen to water. Subunits 1- CC 3 form the functional core of the enzyme complex. CO I is the CC catalytic subunit of the enzyme. Electrons originating in CC cytochrome c are transferred via the copper A center of subunit 2 CC and heme A of subunit 1 to the bimetallic center formed by heme A3 CC and copper B. {ECO:0000256|RuleBase:RU000369}. CC -!- CATALYTIC ACTIVITY: 4 ferrocytochrome c + O(2) + 4 H(+) = 4 CC ferricytochrome c + 2 H(2)O. {ECO:0000256|RuleBase:RU000369}. CC -!- PATHWAY: Energy metabolism; oxidative phosphorylation. CC {ECO:0000256|RuleBase:RU000369}. CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane CC {ECO:0000256|RuleBase:RU000369}; Multi-pass membrane protein CC {ECO:0000256|RuleBase:RU000369}. CC -!- SIMILARITY: Belongs to the heme-copper respiratory oxidase family. CC {ECO:0000256|RuleBase:RU000369}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; KJ142656; AIC79388.1; -; Genomic_DNA. DR EMBL; KJ142674; AIC79424.1; -; Genomic_DNA. DR EMBL; KJ142675; AIC79426.1; -; Genomic_DNA. DR EMBL; KJ142676; AIC79428.1; -; Genomic_DNA. DR EMBL; KJ142679; AIC79434.1; -; Genomic_DNA. DR EMBL; KJ142701; AIC79478.1; -; Genomic_DNA. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell. DR GO; GO:0070469; C:respiratory chain; IEA:UniProtKB-KW. DR GO; GO:0004129; F:cytochrome-c oxidase activity; IEA:UniProtKB-EC. DR GO; GO:0020037; F:heme binding; IEA:InterPro. DR GO; GO:0005506; F:iron ion binding; IEA:InterPro. DR GO; GO:0009060; P:aerobic respiration; IEA:InterPro. DR GO; GO:0006119; P:oxidative phosphorylation; IEA:UniProtKB-UniPathway. DR Gene3D; 1.20.210.10; -; 1. DR InterPro; IPR000883; COX1. DR InterPro; IPR023616; Cyt_c_Oxase_su1_dom. DR PANTHER; PTHR10422; PTHR10422; 1. DR Pfam; PF00115; COX1; 1. DR PRINTS; PR01165; CYCOXIDASEI. DR SUPFAM; SSF81442; SSF81442; 1. DR PROSITE; PS50855; COX1; 1. PE 3: Inferred from homology; KW Copper {ECO:0000256|RuleBase:RU000369}; KW Electron transport {ECO:0000256|RuleBase:RU000369}; KW Heme {ECO:0000256|RuleBase:RU000369}; KW Iron {ECO:0000256|RuleBase:RU000369}; KW Membrane {ECO:0000256|RuleBase:RU000369, ECO:0000256|SAM:Phobius}; KW Metal-binding {ECO:0000256|RuleBase:RU000369}; KW Mitochondrion {ECO:0000256|RuleBase:RU000369, KW ECO:0000313|EMBL:AIC79428.1}; KW Mitochondrion inner membrane {ECO:0000256|RuleBase:RU000369}; KW Oxidoreductase {ECO:0000256|RuleBase:RU000369}; KW Respiratory chain {ECO:0000256|RuleBase:RU000369}; KW Transmembrane {ECO:0000256|RuleBase:RU000369, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}; KW Transport {ECO:0000256|RuleBase:RU000369}. FT TRANSMEM 21 42 Helical. {ECO:0000256|SAM:Phobius}. FT TRANSMEM 54 77 Helical. {ECO:0000256|SAM:Phobius}. FT TRANSMEM 89 108 Helical. {ECO:0000256|SAM:Phobius}. FT TRANSMEM 128 147 Helical. {ECO:0000256|SAM:Phobius}. FT TRANSMEM 159 178 Helical. {ECO:0000256|SAM:Phobius}. FT TRANSMEM 198 224 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 1 263 COX1. {ECO:0000259|PROSITE:PS50855}. FT NON_TER 1 1 {ECO:0000313|EMBL:AIC79428.1}. SQ SEQUENCE 265 AA; 29812 MW; F47F4A1E3930D668 CRC64; GFGMISHIIA HESGKKEVFG NLGMIFAMGA IGLLGFVVWA HHMFTVGMDV DTRAYFTSAT MIIAVPTGIK VFSWLATMYG SKLTLSPPCL WAMGFVFLFT LGGLTGIVLS NSSIDITLHD TYYVVAHFHY VLSMGAVFAI MAGFIQWFPL FTGMSMNPLW LKIQFTTMFI GVNMTFFPQH FLGLAGMPRR YSDYPDMFTA WNIISSMGAI ISMVSMMMFI MIMWESLSSM RQTIFSSHMT SSLEWNHNLP PTEHTYNELP ILIKF //