ID A0A067XH78_TACFU Unreviewed; 771 AA. AC A0A067XH78; DT 01-OCT-2014, integrated into UniProtKB/TrEMBL. DT 01-OCT-2014, sequence version 1. DT 12-AUG-2020, entry version 16. DE RecName: Full=Carnitine O-palmitoyltransferase {ECO:0000256|ARBA:ARBA00013243}; DE EC=2.3.1.21 {ECO:0000256|ARBA:ARBA00013243}; OS Tachysurus fulvidraco (Yellow catfish) (Pimelodus fulvidraco). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Siluriformes; OC Bagridae; Tachysurus. OX NCBI_TaxID=1234273 {ECO:0000313|EMBL:AFO11021.1}; RN [1] {ECO:0000313|EMBL:AFO11021.1} RP NUCLEOTIDE SEQUENCE. RC TISSUE=Liver {ECO:0000313|EMBL:AFO11021.1}; RA Zheng J.L., Luo Z., Chen Q.L., Gong Y., Zhu Q.L., Gu Q.H., Hu W., Liu C.X.; RL Submitted (AUG-2011) to the EMBL/GenBank/DDBJ databases. CC -!- CATALYTIC ACTIVITY: CC Reaction=(R)-carnitine + hexadecanoyl-CoA = CoA + O-hexadecanoyl-(R)- CC carnitine; Xref=Rhea:RHEA:12661, ChEBI:CHEBI:16347, CC ChEBI:CHEBI:17490, ChEBI:CHEBI:57287, ChEBI:CHEBI:57379; EC=2.3.1.21; CC Evidence={ECO:0000256|ARBA:ARBA00001124}; CC -!- PATHWAY: Lipid metabolism; fatty acid beta-oxidation. CC {ECO:0000256|ARBA:ARBA00005005}. CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi- CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}. Mitochondrion CC outer membrane {ECO:0000256|ARBA:ARBA00004374}; Multi-pass membrane CC protein {ECO:0000256|ARBA:ARBA00004374}. CC -!- SIMILARITY: Belongs to the carnitine/choline acetyltransferase family. CC {ECO:0000256|ARBA:ARBA00005232, ECO:0000256|RuleBase:RU003801}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; JN579122; AFO11021.1; -; mRNA. DR UniPathway; UPA00659; -. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0016746; F:transferase activity, transferring acyl groups; IEA:UniProtKB-KW. DR Gene3D; 3.30.559.40; -; 1. DR Gene3D; 3.30.559.70; -; 1. DR InterPro; IPR000542; Carn_acyl_trans. DR InterPro; IPR039551; Cho/carn_acyl_trans. DR InterPro; IPR042232; Cho/carn_acyl_trans_1. DR InterPro; IPR042231; Cho/carn_acyl_trans_2. DR InterPro; IPR032476; CPT_N. DR PANTHER; PTHR22589; PTHR22589; 1. DR Pfam; PF00755; Carn_acyltransf; 1. DR Pfam; PF16484; CPT_N; 1. DR PROSITE; PS00439; ACYLTRANSF_C_1; 1. DR PROSITE; PS00440; ACYLTRANSF_C_2; 1. PE 2: Evidence at transcript level; KW Acyltransferase {ECO:0000256|ARBA:ARBA00023315, KW ECO:0000256|RuleBase:RU003801}; KW Fatty acid metabolism {ECO:0000256|ARBA:ARBA00022832}; KW Lipid metabolism {ECO:0000256|ARBA:ARBA00023098}; KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius}; KW Mitochondrion {ECO:0000256|ARBA:ARBA00023128}; KW Mitochondrion outer membrane {ECO:0000256|ARBA:ARBA00022787}; KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|RuleBase:RU003801, KW ECO:0000313|EMBL:AFO11021.1}; KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989, KW ECO:0000256|SAM:Phobius}. FT TRANSMEM 54..75 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 104..126 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT DOMAIN 1..46 FT /note="CPT_N" FT /evidence="ECO:0000259|Pfam:PF16484" FT DOMAIN 171..759 FT /note="Carn_acyltransf" FT /evidence="ECO:0000259|Pfam:PF00755" FT ACT_SITE 471 FT /note="Proton acceptor" FT /evidence="ECO:0000256|PIRSR:PIRSR600542-1" SQ SEQUENCE 771 AA; 88755 MW; AF6ADB6F89F868AF CRC64; MAEAHQAVAF QFTVTPEGID LRLSREALKH IYLARVTSWR KRVILFRNGI RMGVYPASPS SWLFVVIVIM SSMYARLDPS MGMINSIKKV LPASDHLTSQ AQTVLSAIVF ATGLWFSLIM LLRYILKVLL SYHGWIFEPH GKMSMTTKLW ISLLKMFSGH RPLLYSFQGS LPRLPVPSID DTINRYLESV RPLLDDDRYK QMEIVANEFK KDQAPKLQKY LKLKSWWANN YVSDWWEEYI YLRGRGPIMV NSNFYTMDLL YMIPTHRQAA RAGNVVHAIL QYRRKLERGE HAPMRALGVV PMCSYQYEGM FNTTRIPGIE TDCVQHLRNR KHLVVYHKGR FFKVWLYYGG RHLLPAELEQ QFQHILNDTT EPQSGELKLA SLTAGNRVPW AKARQKHFSD GVNKTSLDTI ETAAFFLTLD DESHGYDPEN PRSMDLYAKS LLHGKCYDRW FDKSFNLIIF KNGTMGLNAE HTWADAPIVG HLWEHVLSMD PITLGYTEDG HCRGKPHPNL PGPLRLQWDI SVECQSVIRS SLKVANALAD DVDMHIFPFN NFGKGLIKKC KTSPDGFIQI ALQLAHFRDK KKFCLTYEAS MTRLFREGRT ETVRSCTMET CDFVRAMMDE KQTREEKLRL LKLAAEKHQE LYRMAMTGKG IDRHIFCLYV VSKYLGDDSA FLKEVLSEPW RLSTSQTPLQ QIELFDLKKH PEYVTSGGGF GPVADDGYGV SYIILGEDLI NFHISSKYSS IETDSHRFGN HIKQAMLDIL ALFELDKKTV K //