ID A0A063YWA7_9BACI Unreviewed; 489 AA. AC A0A063YWA7; DT 03-SEP-2014, integrated into UniProtKB/TrEMBL. DT 03-SEP-2014, sequence version 1. DT 20-JAN-2016, entry version 11. DE RecName: Full=UDP-N-acetylmuramyl-tripeptide synthetase {ECO:0000256|SAAS:SAAS00382050}; DE EC=6.3.2.- {ECO:0000256|SAAS:SAAS00382149}; GN ORFNames=DI44_05225 {ECO:0000313|EMBL:KDE49430.1}; OS Geobacillus sp. CAMR5420. OC Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Geobacillus. OX NCBI_TaxID=1482739 {ECO:0000313|EMBL:KDE49430.1, ECO:0000313|Proteomes:UP000027227}; RN [1] {ECO:0000313|EMBL:KDE49430.1, ECO:0000313|Proteomes:UP000027227} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=CAMR5420 {ECO:0000313|EMBL:KDE49430.1, RC ECO:0000313|Proteomes:UP000027227}; RA De Maayer P., Willliamson C.E., Vennard C.T., Danson M.J., Cowan D.A.; RT "The draft genomes of Geobacillus sp. CAMR5420 and CAMR12739."; RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases. CC -!- PATHWAY: Cell wall biogenesis; peptidoglycan biosynthesis. CC {ECO:0000256|RuleBase:RU004135, ECO:0000256|SAAS:SAAS00382078}. CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|RuleBase:RU004135, CC ECO:0000256|SAAS:SAAS00382122}. CC -!- CAUTION: The sequence shown here is derived from an CC EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is CC preliminary data. {ECO:0000313|EMBL:KDE49430.1}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; JHUS01000029; KDE49430.1; -; Genomic_DNA. DR RefSeq; WP_014195372.1; NZ_JHUS01000029.1. DR EnsemblBacteria; KDE49430; KDE49430; DI44_05225. DR UniPathway; UPA00219; -. DR Proteomes; UP000027227; Unassembled WGS sequence. DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. DR GO; GO:0016881; F:acid-amino acid ligase activity; IEA:InterPro. DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW. DR GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW. DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW. DR GO; GO:0071555; P:cell wall organization; IEA:UniProtKB-KW. DR GO; GO:0009252; P:peptidoglycan biosynthetic process; IEA:UniProtKB-UniPathway. DR GO; GO:0008360; P:regulation of cell shape; IEA:UniProtKB-KW. DR Gene3D; 3.40.1190.10; -; 1. DR Gene3D; 3.40.1390.10; -; 1. DR Gene3D; 3.90.190.20; -; 1. DR HAMAP; MF_00208; MurE; 1. DR InterPro; IPR004101; Mur_ligase_C. DR InterPro; IPR013221; Mur_ligase_cen. DR InterPro; IPR000713; Mur_ligase_N. DR InterPro; IPR005761; UDP-N-AcMur-Glu-dNH2Pim_ligase. DR Pfam; PF01225; Mur_ligase; 1. DR Pfam; PF02875; Mur_ligase_C; 1. DR Pfam; PF08245; Mur_ligase_M; 1. DR SUPFAM; SSF53244; SSF53244; 1. DR SUPFAM; SSF53623; SSF53623; 1. DR SUPFAM; SSF63418; SSF63418; 1. DR TIGRFAMs; TIGR01085; murE; 1. PE 3: Inferred from homology; KW ATP-binding {ECO:0000256|SAAS:SAAS00085443}; KW Cell cycle {ECO:0000256|RuleBase:RU004135, KW ECO:0000256|SAAS:SAAS00085467}; KW Cell division {ECO:0000256|RuleBase:RU004135, KW ECO:0000256|SAAS:SAAS00085386}; KW Cell shape {ECO:0000256|RuleBase:RU004135, KW ECO:0000256|SAAS:SAAS00085370}; KW Cell wall biogenesis/degradation {ECO:0000256|RuleBase:RU004135, KW ECO:0000256|SAAS:SAAS00085405}; KW Complete proteome {ECO:0000313|Proteomes:UP000027227}; KW Cytoplasm {ECO:0000256|SAAS:SAAS00085419}; KW Ligase {ECO:0000256|SAAS:SAAS00085462, ECO:0000313|EMBL:KDE49430.1}; KW Nucleotide-binding {ECO:0000256|SAAS:SAAS00085432}; KW Peptidoglycan synthesis {ECO:0000256|RuleBase:RU004135, KW ECO:0000256|SAAS:SAAS00085400}. FT DOMAIN 25 94 Mur_ligase. {ECO:0000259|Pfam:PF01225}. FT DOMAIN 106 312 Mur_ligase_M. {ECO:0000259|Pfam:PF08245}. FT DOMAIN 332 417 Mur_ligase_C. {ECO:0000259|Pfam:PF02875}. SQ SEQUENCE 489 AA; 53350 MW; 8381F179FE07B341 CRC64; MKLLTLLSHL PGFWVHHGGN PDIVALEMDS RRVASGSLFF CLKGFTVDGH DFAEEAVARG AAAIVAERPL SVDVPVVLVS DSRRTMAILA DAFYGRPTHR LHLIGVTGTN GKTTTTSIIE QIARKAGKKT GLIGTVHIKV GDRSYPAANT TPESLILQRM FKQMVDEGVE FVAMEVSSHA LHQGRVHGCD YDVAVFTNLT QDHLDYHGTM EEYRNAKGLL FAQLGNRYDE RRPKFAVLNH DDPVSQYYKH MTAAPIVTYG MREKSDVMAE QIRMTAGGMA FRLCTPHGSA AVETKLVGSF NVYNILAAAA ACLASGFSLE TIAAALADVE PVPGRFETVD EGQNFTIIVD YAHTPDSLEN ALKTVRQLAK RNVYVVIGCG GDRDPSKRPL MAQVAVRYAD VAIFTSDNPR SEDPKQILRD MEAGVSAEIG KHVTIPDREE AIRYAIGQAQ EGDVVLIAGK GHETYQIIGN DVIEFDDRAV ARAAVKERG //