ID   A0A062XVB6_9BACT        Unreviewed;       441 AA.
AC   A0A062XVB6;
DT   03-SEP-2014, integrated into UniProtKB/TrEMBL.
DT   03-SEP-2014, sequence version 1.
DT   16-JAN-2019, entry version 26.
DE   RecName: Full=Zinc metalloprotease {ECO:0000256|RuleBase:RU362031};
DE            EC=3.4.24.- {ECO:0000256|RuleBase:RU362031};
GN   ORFNames=EG19_06125 {ECO:0000313|EMBL:KDA53324.1};
OS   Thermoanaerobaculum aquaticum.
OC   Bacteria; Acidobacteria; Acidobacteria subdivision 23;
OC   Thermoanaerobaculum.
OX   NCBI_TaxID=1312852 {ECO:0000313|EMBL:KDA53324.1, ECO:0000313|Proteomes:UP000027284};
RN   [1] {ECO:0000313|EMBL:KDA53324.1, ECO:0000313|Proteomes:UP000027284}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MP-01 {ECO:0000313|EMBL:KDA53324.1,
RC   ECO:0000313|Proteomes:UP000027284};
RA   Stamps B.W., Losey N.A., Lawson P.A., Stevenson B.S.;
RT   "The Genome Sequence of Thermoanaerobaculum aquaticum MP-01, The First
RT   Cultivated Group 23 Acidobacterium.";
RL   Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC         Evidence={ECO:0000256|RuleBase:RU362031,
CC         ECO:0000256|SAAS:SAAS00913187};
CC   -!- SIMILARITY: Belongs to the peptidase M50B family.
CC       {ECO:0000256|RuleBase:RU362031, ECO:0000256|SAAS:SAAS00563376}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:KDA53324.1}.
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DR   EMBL; JMFG01000023; KDA53324.1; -; Genomic_DNA.
DR   RefSeq; WP_038049849.1; NZ_JMFG01000023.1.
DR   MEROPS; M50.004; -.
DR   EnsemblBacteria; KDA53324; KDA53324; EG19_06125.
DR   OrthoDB; 1395197at2; -.
DR   Proteomes; UP000027284; Unassembled WGS sequence.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0004222; F:metalloendopeptidase activity; IEA:InterPro.
DR   InterPro; IPR001478; PDZ.
DR   InterPro; IPR036034; PDZ_sf.
DR   InterPro; IPR004387; Pept_M50_Zn.
DR   InterPro; IPR008915; Peptidase_M50.
DR   Pfam; PF13180; PDZ_2; 1.
DR   Pfam; PF02163; Peptidase_M50; 1.
DR   SMART; SM00228; PDZ; 2.
DR   SUPFAM; SSF50156; SSF50156; 2.
DR   TIGRFAMs; TIGR00054; TIGR00054; 1.
DR   PROSITE; PS50106; PDZ; 2.
PE   3: Inferred from homology;
KW   Cell membrane {ECO:0000256|SAAS:SAAS00090065};
KW   Complete proteome {ECO:0000313|Proteomes:UP000027284};
KW   Hydrolase {ECO:0000256|RuleBase:RU362031,
KW   ECO:0000256|SAAS:SAAS00069908};
KW   Membrane {ECO:0000256|RuleBase:RU362031,
KW   ECO:0000256|SAAS:SAAS00069850};
KW   Metal-binding {ECO:0000256|RuleBase:RU362031,
KW   ECO:0000256|SAAS:SAAS00913207};
KW   Metalloprotease {ECO:0000256|RuleBase:RU362031,
KW   ECO:0000256|SAAS:SAAS00069945};
KW   Protease {ECO:0000256|SAAS:SAAS00069928};
KW   Reference proteome {ECO:0000313|Proteomes:UP000027284};
KW   Transmembrane {ECO:0000256|RuleBase:RU362031,
KW   ECO:0000256|SAAS:SAAS00069900};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU362031,
KW   ECO:0000256|SAAS:SAAS00069864};
KW   Zinc {ECO:0000256|RuleBase:RU362031, ECO:0000256|SAAS:SAAS00450985}.
FT   TRANSMEM     95    121       Helical. {ECO:0000256|RuleBase:RU362031}.
FT   TRANSMEM    411    429       Helical. {ECO:0000256|RuleBase:RU362031}.
FT   DOMAIN      119    198       PDZ. {ECO:0000259|PROSITE:PS50106}.
FT   DOMAIN      217    246       PDZ. {ECO:0000259|PROSITE:PS50106}.
SQ   SEQUENCE   441 AA;  47636 MW;  D1F6F0F3E63C8D8E CRC64;
     MLVNALSLIV VIGILVLLHE GGHFLAARLV GAPVAVFSVG FGKRLFGFRW GGTDFRWSLI
     PLGGYVRILG LGPDESDVVQ PGQAPVPLLP RWKRAVILVA GPAANVVGAL AFMALAFNLG
     VEVPAWQDQK PVVGWVDPAS PAAQAGIKAG DEVLAVDGKA IKRWRDLEMV TISSPNRELS
     VKLRRGNEEL TVPLKPKSVS RYALGWAGLA PPIPAEVQRV MPGSPAEKAG LLPGDRIVSV
     DGNPVEHFFD LVRLVGERPE KEISLQVLRN GELVTLSATT RSEAGQGKLG IPIPSWQVIR
     KLPAGQAVRE AVLECRRMTA ETLWVLSRMV TGRASIRQMS GPIDIAKFSG EAARSGLVPL
     IWLLGVISLQ LAIFNLLPIP VLDGGHLVIV AAEGIRRRDF SFKTKERITN VGFWLIMALI
     LFVLANDVVK NLPALWPRSQ P
//