ID A0A060VEM3_KLEPN Unreviewed; 298 AA. AC A0A060VEM3; A0A0J2FNU8; A0A4V0H0I6; DT 03-SEP-2014, integrated into UniProtKB/TrEMBL. DT 03-SEP-2014, sequence version 1. DT 27-NOV-2024, entry version 86. DE RecName: Full=Tyrosine recombinase XerD {ECO:0000256|ARBA:ARBA00015810, ECO:0000256|HAMAP-Rule:MF_01807}; GN Name=xerD_1 {ECO:0000313|EMBL:SXN30647.1}; GN Synonyms=xerD {ECO:0000256|HAMAP-Rule:MF_01807, GN ECO:0000313|EMBL:KII07241.1}, xerD_2 {ECO:0000313|EMBL:SQC22324.1}, GN xerD_3 {ECO:0000313|EMBL:STT81935.1}, xerD_4 GN {ECO:0000313|EMBL:STT06328.1}; GN ORFNames=APT92_25765 {ECO:0000313|EMBL:KSX87577.1}, B5L96_14520 GN {ECO:0000313|EMBL:OVF70901.1}, B6I68_10345 GN {ECO:0000313|EMBL:PLE27793.1}, BANRA_00859 GN {ECO:0000313|EMBL:VCX96258.1}, BANRA_02604 GN {ECO:0000313|EMBL:VCV76643.1}, BL124_00033500 GN {ECO:0000313|EMBL:ROG84450.1}, BV369_09080 GN {ECO:0000313|EMBL:OWA82504.1}, CP554_00065 GN {ECO:0000313|EMBL:PVU64335.1}, DM083_01890 GN {ECO:0000313|EMBL:RCJ54523.1}, DW281_12810 GN {ECO:0000313|EMBL:RDT88972.1}, EAO17_09240 GN {ECO:0000313|EMBL:RRF06376.1}, EXT45_09365 GN {ECO:0000313|EMBL:RZG38655.1}, FME62_23165 GN {ECO:0000313|EMBL:MSS33672.1}, FXN67_05480 GN {ECO:0000313|EMBL:TYL81586.1}, G4V31_24215 GN {ECO:0000313|EMBL:NGN75204.1}, GJJ01_23895 GN {ECO:0000313|EMBL:MRJ98980.1}, GJJ08_004405 GN {ECO:0000313|EMBL:QOU52670.1}, GJJ18_24915 GN {ECO:0000313|EMBL:MRL38647.1}, GNF00_24250 GN {ECO:0000313|EMBL:MUA42959.1}, H3G96_023290 GN {ECO:0000313|EMBL:QQL33013.1}, HV185_04130 GN {ECO:0000313|EMBL:QLO17737.1}, I8R04_02190 GN {ECO:0000313|EMBL:MBH8348811.1}, JMZ77_04425 GN {ECO:0000313|EMBL:QQZ72456.1}, LS45_08105 GN {ECO:0000313|EMBL:KII07241.1}, NCTC11679_00882 GN {ECO:0000313|EMBL:STV33488.1}, NCTC13443_06275 GN {ECO:0000313|EMBL:STT06328.1}, NCTC13465_03909 GN {ECO:0000313|EMBL:SQC45359.1}, NCTC13635_02708 GN {ECO:0000313|EMBL:VEB02248.1}, NCTC204_03084 GN {ECO:0000313|EMBL:STV03030.1}, NCTC5047_02873 GN {ECO:0000313|EMBL:STT81935.1}, NCTC5052_04183 GN {ECO:0000313|EMBL:STT95675.1}, NCTC5053_05258 GN {ECO:0000313|EMBL:STV51837.1}, NCTC8849_05245 GN {ECO:0000313|EMBL:STT56586.1}, NCTC9645_02901 GN {ECO:0000313|EMBL:SQC22324.1}, NCTC9661_01619 GN {ECO:0000313|EMBL:STU29063.1}, Q6294_24575 GN {ECO:0000313|EMBL:MDP0970194.1}, SAMEA2273558_02194 GN {ECO:0000313|EMBL:SBH13745.1}, SAMEA3499874_00840 GN {ECO:0000313|EMBL:SXG11045.1}, SAMEA3499901_01654 GN {ECO:0000313|EMBL:SXN30647.1}, SAMEA3515122_02164 GN {ECO:0000313|EMBL:SYH31270.1}, SAMEA3538551_03684 GN {ECO:0000313|EMBL:SYC20720.1}, SAMEA3538828_01629 GN {ECO:0000313|EMBL:SYR35506.1}, SAMEA3649591_00289 GN {ECO:0000313|EMBL:SVN62221.1}, SAMEA3649615_04738 GN {ECO:0000313|EMBL:SYU76819.1}, SAMEA3720909_02519 GN {ECO:0000313|EMBL:SWF72294.1}, SAMEA3729652_01762 GN {ECO:0000313|EMBL:SWT11023.1}, SAMEA4364603_00912 GN {ECO:0000313|EMBL:SSK22593.1}, SAMEA4873597_01096 GN {ECO:0000313|EMBL:VGJ15405.1}, SAMEA4873632_04892 GN {ECO:0000313|EMBL:VGL14206.1}; OS Klebsiella pneumoniae. OC Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; OC Enterobacteriaceae; Klebsiella/Raoultella group; Klebsiella. OX NCBI_TaxID=573 {ECO:0000313|EMBL:SXN30647.1, ECO:0000313|Proteomes:UP000259975}; RN [1] {ECO:0000313|EMBL:KII07241.1, ECO:0000313|Proteomes:UP000031820} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=UMNturkey9 {ECO:0000313|EMBL:KII07241.1, RC ECO:0000313|Proteomes:UP000031820}; RA Lang K., Dorn K., Danzeisen J., Johnson T.; RT "Plasmid movement, recombination, and chromosomal integration amongst RT multidrug resistant commensal Escherichia coli clones within a single RT commercial turkey flock."; RL Submitted (OCT-2014) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|EMBL:KSX87577.1, ECO:0000313|Proteomes:UP000052969} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=50627996 {ECO:0000313|EMBL:KSX87577.1, RC ECO:0000313|Proteomes:UP000052969}; RA Samuelsen O.; RL Submitted (OCT-2015) to the EMBL/GenBank/DDBJ databases. RN [3] {ECO:0000313|EMBL:PLE27793.1, ECO:0000313|Proteomes:UP000234439} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=COL-Kpn30 {ECO:0000313|EMBL:PLE27793.1, RC ECO:0000313|Proteomes:UP000234439}; RX PubMed=29029188; DOI=.1093/infdis/jix524; RA Rojas L.J., Weinstock G.M., De La Cadena E., Diaz L., Rios R., Hanson B.M., RA Brown J.S., Vats P., Phillips D.S., Nguyen H., Hujer K.M., Correa A., RA Adams M.D., Perez F., Sodergren E., Narechania A., Planet P.J., RA Villegas M.V., Bonomo R.A., Arias C.A.; RT "An Analysis of the Epidemic of Klebsiella pneumoniae Carbapenemase- RT Producing K. pneumoniae: Convergence of Two Evolutionary Mechanisms Creates RT the Perfect Storm."; RL J. Infect. Dis. 217:82-92(2017). RN [4] {ECO:0000313|EMBL:OWA82504.1, ECO:0000313|Proteomes:UP000195348} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=C6-E2-14 {ECO:0000313|EMBL:OWA82504.1, RC ECO:0000313|Proteomes:UP000195348}; RA Jaidane N., Mansour W., Bonnin R., Boujafar N., Bouallegue O., Naas T.; RT "Colistin Resistant Klebsiella pneumoniae C6."; RL Submitted (JAN-2017) to the EMBL/GenBank/DDBJ databases. RN [5] {ECO:0000313|EMBL:OVF70901.1, ECO:0000313|Proteomes:UP000196447} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=39383 {ECO:0000313|EMBL:OVF70901.1, RC ECO:0000313|Proteomes:UP000196447}; RA Fouts D., Stalin M.J., Chen L., Wright M., Sutton G., Nguyen K., RA Vanduin D., Rojas L., Hujer A., Hujer K., Bonomo R., Kreiswirth B., RA Adams M.; RL Submitted (MAR-2017) to the EMBL/GenBank/DDBJ databases. RN [6] {ECO:0000313|EMBL:PVU64335.1, ECO:0000313|Proteomes:UP000245817} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=HH516E4IA {ECO:0000313|EMBL:PVU64335.1, RC ECO:0000313|Proteomes:UP000245817}; RA Founou L., Founou R.C., Allam M., Ismail A., Essack S.Y.; RT "Molecular Epidemiology of Livestock-Associated Methicillin Resistant RT Staphylococcus aureus (LA-MRSA) and Extended-Spectrum Beta-Lactamase RT (ESBL)-Producing Enterobacteriaceae in Pigs and Exposed Workers in Cameroon RT and South Africa."; RL Submitted (SEP-2017) to the EMBL/GenBank/DDBJ databases. RN [7] {ECO:0000313|EMBL:RRF06376.1, ECO:0000313|Proteomes:UP000275975} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=KLPN_104 {ECO:0000313|EMBL:RRF06376.1, RC ECO:0000313|Proteomes:UP000275975}; RX PubMed=30373801; RA Tamma P.D., Fan Y., Bergman Y., Pertea G., Kazmi A., Lewis S., RA Carroll K.C., Schatz M.C., Timp W., Simner P.J.; RT "Applying Rapid Whole Genome Sequencing to Predict Phenotypic Antimicrobial RT Susceptibility Testing Results Among Carbapenem-Resistant Klebsiella RT pneumoniae Clinical Isolates."; RL Antimicrob. Agents Chemother. 0:0-0(2018). RN [8] {ECO:0000313|Proteomes:UP000250675, ECO:0000313|Proteomes:UP000251721} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=NCTC11679 {ECO:0000313|EMBL:STV33488.1, RC ECO:0000313|Proteomes:UP000255239}, NCTC13443 RC {ECO:0000313|EMBL:STT06328.1, ECO:0000313|Proteomes:UP000255518}, RC NCTC13465 {ECO:0000313|EMBL:SQC45359.1, RC ECO:0000313|Proteomes:UP000251721}, NCTC204 RC {ECO:0000313|EMBL:STV03030.1, ECO:0000313|Proteomes:UP000255192}, RC NCTC5047 {ECO:0000313|EMBL:STT81935.1, RC ECO:0000313|Proteomes:UP000254340}, NCTC5052 RC {ECO:0000313|EMBL:STT95675.1, ECO:0000313|Proteomes:UP000254103}, RC NCTC5053 {ECO:0000313|EMBL:STV51837.1, RC ECO:0000313|Proteomes:UP000254387}, NCTC8849 RC {ECO:0000313|EMBL:STT56586.1, ECO:0000313|Proteomes:UP000254799}, RC NCTC9645 {ECO:0000313|EMBL:SQC22324.1, RC ECO:0000313|Proteomes:UP000250675}, and NCTC9661 RC {ECO:0000313|EMBL:STU29063.1, ECO:0000313|Proteomes:UP000255137}; RG Pathogen Informatics; RA Doyle S.; RL Submitted (JUN-2018) to the EMBL/GenBank/DDBJ databases. RN [9] {ECO:0000313|EMBL:RDT88972.1, ECO:0000313|Proteomes:UP000254680} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=K280 {ECO:0000313|EMBL:RDT88972.1, RC ECO:0000313|Proteomes:UP000254680}; RA He F.; RT "Draft genome sequence of Klebsiella pneumoniae K280."; RL Submitted (JUL-2018) to the EMBL/GenBank/DDBJ databases. RN [10] {ECO:0000313|Proteomes:UP000253135} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=BC_4987 {ECO:0000313|Proteomes:UP000253135}; RA Martins R.C.R., Perdigao-Neto L.V., Costa S.F., Levin A.S.S.; RT "Klebsiella pneumoniae genome sequencing and assembly."; RL Submitted (JUL-2018) to the EMBL/GenBank/DDBJ databases. RN [11] {ECO:0000313|EMBL:RCJ54523.1, ECO:0000313|Proteomes:UP000253135} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=BC_4987 {ECO:0000313|EMBL:RCJ54523.1, RC ECO:0000313|Proteomes:UP000253135}; RA Martins R.C., Perdigao-Neto L.V., Costa S.F., Levin A.S.S.; RL Submitted (JUL-2018) to the EMBL/GenBank/DDBJ databases. RN [12] {ECO:0000313|EMBL:RCJ54523.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=BC_4987 {ECO:0000313|EMBL:RCJ54523.1}; RA Martins R.C.R., Perdigao-Neto L.V., Costa S.F., Levin A.S.S.; RT "Klebsiella pneumoniae genome sequencing and assembly."; RL Submitted (AUG-2018) to the EMBL/GenBank/DDBJ databases. RN [13] {ECO:0000313|Proteomes:UP000257587, ECO:0000313|Proteomes:UP000258232} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=4300STDY6470422 {ECO:0000313|EMBL:SSK22593.1, RC ECO:0000313|Proteomes:UP000252603}, 5012STDY7626396 RC {ECO:0000313|EMBL:VGJ15405.1, ECO:0000313|Proteomes:UP000295133}, RC 5012STDY7626430 {ECO:0000313|EMBL:VGL14206.1, RC ECO:0000313|Proteomes:UP000376235}, EuSCAPE_AT002 RC {ECO:0000313|EMBL:SXG11045.1, ECO:0000313|Proteomes:UP000257587}, RC EuSCAPE_AT029 {ECO:0000313|EMBL:SXN30647.1, RC ECO:0000313|Proteomes:UP000259975}, EuSCAPE_ES277 RC {ECO:0000313|EMBL:SYU76819.1, ECO:0000313|Proteomes:UP000259417}, RC EuSCAPE_GR003 {ECO:0000313|EMBL:SVN62221.1, RC ECO:0000313|Proteomes:UP000258905}, EuSCAPE_HU047 RC {ECO:0000313|EMBL:SYR35506.1, ECO:0000313|Proteomes:UP000258253}, RC EuSCAPE_IT093 {ECO:0000313|EMBL:SYH31270.1, RC ECO:0000313|Proteomes:UP000258673}, EuSCAPE_ME009 RC {ECO:0000313|EMBL:SYC20720.1, ECO:0000313|Proteomes:UP000258232}, RC EuSCAPE_TR125 {ECO:0000313|EMBL:SWT11023.1, RC ECO:0000313|Proteomes:UP000258798}, EuSCAPE_UK014 RC {ECO:0000313|EMBL:SWF72294.1, ECO:0000313|Proteomes:UP000259364}, K480 RC {ECO:0000313|EMBL:SBH13745.1}, k480 RC {ECO:0000313|Proteomes:UP000077826}, and NCTC13635 RC {ECO:0000313|EMBL:VEB02248.1, ECO:0000313|Proteomes:UP000282433}; RG Pathogen Informatics; RL Submitted (AUG-2018) to the EMBL/GenBank/DDBJ databases. RN [14] {ECO:0000313|EMBL:ROG84450.1, ECO:0000313|Proteomes:UP000283322} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=CRK0165 {ECO:0000313|EMBL:ROG84450.1, RC ECO:0000313|Proteomes:UP000283322}; RA Vanduin D., Fouts D., Wright M., Sutton G., Nguyen K., Kreiswirth B., RA Chen L., Rojas L., Hujer A., Hujer K., Bonomo R., Adams M.; RL Submitted (OCT-2018) to the EMBL/GenBank/DDBJ databases. RN [15] {ECO:0000313|Proteomes:UP000269921, ECO:0000313|Proteomes:UP000278966} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Kpneu006 {ECO:0000313|EMBL:VCV76643.1}, and Kpneu025 RC {ECO:0000313|EMBL:VCX96258.1}; RA Noll B N.; RL Submitted (OCT-2018) to the EMBL/GenBank/DDBJ databases. RN [16] {ECO:0000313|EMBL:RZG38655.1, ECO:0000313|Proteomes:UP000293472} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=53 {ECO:0000313|EMBL:RZG38655.1, RC ECO:0000313|Proteomes:UP000293472}; RA Newire E., Aydin A., Juma S., Enne V., Roberts A.P.; RT "Identification of a Type IV CRISPR-Cas system located exclusively on RT IncHI1B/ IncFIB plasmids in Enterobacteriaceae."; RL Submitted (FEB-2019) to the EMBL/GenBank/DDBJ databases. RN [17] {ECO:0000313|EMBL:MSS33672.1, ECO:0000313|Proteomes:UP000468995} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=EN5275 {ECO:0000313|EMBL:MSS33672.1, RC ECO:0000313|Proteomes:UP000468995}; RA Mukherjee S., Naha S., Bhadury P., Basu S.; RT "Genome sequence of OXA-232-producing Klebsiella pneumoniae ST23 from RT septicemic neonate."; RL Submitted (JUL-2019) to the EMBL/GenBank/DDBJ databases. RN [18] {ECO:0000313|EMBL:TYL81586.1, ECO:0000313|Proteomes:UP000322977} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=UCO-494 {ECO:0000313|EMBL:TYL81586.1, RC ECO:0000313|Proteomes:UP000322977}; RA Morales-Leon F., Caro C., Opazo-Capurro A., Lincopan N., RA Dominguez-Yevenes M., Lima C., Bello-Toledo H., Gonzalez-Rocha G.; RT "Phenotypic and genetic characterization of extended-spectrum b-lactamase- RT producing hypermucoviscous Klebsiella pneumoniae from Chile."; RL Submitted (AUG-2019) to the EMBL/GenBank/DDBJ databases. RN [19] {ECO:0000313|EMBL:MRL38647.1} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=CriePir115 {ECO:0000313|EMBL:MRL38647.1}, and CriePir226 RC {ECO:0000313|EMBL:MRJ98980.1, ECO:0000313|Proteomes:UP000441029}; RA Shelenkov A., Mikhaylova Y., Yanushevich Y., Samoilov A., Petrova L., RA Fomina V., Gusarov V., Zamyatin M., Shagin D.; RT "Molecular typing, antibiotic resistance determination and virulence RT profiling for 36 multidrug-resistant clinical Klebsiella pneumoniae RT isolates using second- and third-generation sequencing."; RL Submitted (OCT-2019) to the EMBL/GenBank/DDBJ databases. RN [20] {ECO:0000313|EMBL:MUA42959.1, ECO:0000313|Proteomes:UP000485085} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=KP_38044 {ECO:0000313|EMBL:MUA42959.1, RC ECO:0000313|Proteomes:UP000485085}; RA Zhou K.; RT "Emergence of a novel subclone of carbapenem-resistant Klebsiella RT pneumoniae ST11 with enhanced virulence and transmissibility: a molecular RT epidemiological, clinical, genomic study."; RL Submitted (NOV-2019) to the EMBL/GenBank/DDBJ databases. RN [21] {ECO:0000313|EMBL:QOU52670.1, ECO:0000313|Proteomes:UP000439817} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=CriePir120 {ECO:0000313|EMBL:QOU52670.1, RC ECO:0000313|Proteomes:UP000439817}; RX PubMed=32429555; RA Shelenkov A., Mikhaylova Y., Yanushevich Y., Samoilov A., Petrova L., RA Fomina V., Gusarov V., Zamyatin M., Shagin D., Akimkin V.; RT "Molecular Typing, Characterization of Antimicrobial Resistance, Virulence RT Profiling and Analysis of Whole-Genome Sequence of Clinical Klebsiella RT pneumoniae Isolates."; RL Antibiotics 9:E261-E261(2020). RN [22] {ECO:0000313|EMBL:NGN75204.1, ECO:0000313|Proteomes:UP000479475} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=2429 {ECO:0000313|EMBL:NGN75204.1, RC ECO:0000313|Proteomes:UP000479475}; RA Starkova P.S., Sulyan O.S., Likholetova D.V., Ageevets V.A., Lazareva I.V., RA Sopova J.V., Sidorenko S.V.; RT "Klebsiella pneumoniae genome sequencing and assembly."; RL Submitted (FEB-2020) to the EMBL/GenBank/DDBJ databases. RN [23] {ECO:0000313|Proteomes:UP000512241} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=RHBSTW-00405 {ECO:0000313|Proteomes:UP000512241}; RA Shaw L.P.; RT "REHAB project genomes."; RL Submitted (JUN-2020) to the EMBL/GenBank/DDBJ databases. RN [24] {ECO:0000313|EMBL:QQL33013.1, ECO:0000313|Proteomes:UP000532829} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=WCHKP090374 {ECO:0000313|EMBL:QQL33013.1, RC ECO:0000313|Proteomes:UP000532829}; RA Wei L., Wen H., Liu L., Feng Y., Zong Z.; RT "The complete genome of Klebsiella pneumoniae strain 090374."; RL Submitted (DEC-2020) to the EMBL/GenBank/DDBJ databases. RN [25] {ECO:0000313|EMBL:MBH8348811.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=CCBH27695 {ECO:0000313|EMBL:MBH8348811.1}; RA Silveira M.C., Claudio R.-D.-S.M., Ana Paula C.-A.D.; RT "WGS of multidrug-resistant bacteria from different Brazilian states."; RL Submitted (DEC-2020) to the EMBL/GenBank/DDBJ databases. RN [26] {ECO:0000313|EMBL:QLO17737.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=RHBSTW-00405 {ECO:0000313|EMBL:QLO17737.1}; RX PubMed=34609275; RA AbuOun M., Jones H., Stubberfield E., Gilson D., Shaw L.P., Hubbard A.T.M., RA Chau K.K., Sebra R., Peto T.E.A., Crook D.W., Read D.S., Gweon H.S., RA Walker A.S., Stoesser N., Smith R.P., Anjum M.F., RA On Behalf Of The Rehab Consortium.; RT "A genomic epidemiological study shows that prevalence of antimicrobial RT resistance in Enterobacterales is associated with the livestock host, as RT well as antimicrobial usage."; RL Microb. Genom. 7:0-0(2021). RN [27] {ECO:0000313|EMBL:QQZ72456.1, ECO:0000313|Proteomes:UP000595568} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=59493 {ECO:0000313|EMBL:QQZ72456.1, RC ECO:0000313|Proteomes:UP000595568}; RA Chen L., Kreiswirth B.; RT "Genome sequencing of apramycin resistant K. pneumoniae."; RL Submitted (JAN-2021) to the EMBL/GenBank/DDBJ databases. RN [28] {ECO:0000313|EMBL:MDP0970194.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=KP219 {ECO:0000313|EMBL:MDP0970194.1}; RA Peng Z.; RL Submitted (JUL-2023) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Site-specific tyrosine recombinase, which acts by catalyzing CC the cutting and rejoining of the recombining DNA molecules. Binds CC cooperatively to specific DNA consensus sequences that are separated CC from XerC binding sites by a short central region, forming the CC heterotetrameric XerC-XerD complex that recombines DNA substrates. The CC complex is essential to convert dimers of the bacterial chromosome into CC monomers to permit their segregation at cell division. It also CC contributes to the segregational stability of plasmids. In the complex CC XerD specifically exchanges the bottom DNA strands. {ECO:0000256|HAMAP- CC Rule:MF_01807}. CC -!- ACTIVITY REGULATION: FtsK may regulate the catalytic switch between CC XerC and XerD in the heterotetrameric complex during the two steps of CC the recombination process. {ECO:0000256|HAMAP-Rule:MF_01807}. CC -!- SUBUNIT: Forms a cyclic heterotetrameric complex composed of two CC molecules of XerC and two molecules of XerD, in which XerC interacts CC with XerD via its C-terminal region, XerD interacts with XerC via its CC C-terminal region and so on. {ECO:0000256|ARBA:ARBA00011483, CC ECO:0000256|HAMAP-Rule:MF_01807}. CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496, CC ECO:0000256|HAMAP-Rule:MF_01807}. CC -!- SIMILARITY: Belongs to the 'phage' integrase family. XerD subfamily. CC {ECO:0000256|ARBA:ARBA00010450, ECO:0000256|HAMAP-Rule:MF_01807}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; JRRF01000004; KII07241.1; -; Genomic_DNA. DR EMBL; LNHP01000054; KSX87577.1; -; Genomic_DNA. DR EMBL; JAECTB010000001; MBH8348811.1; -; Genomic_DNA. DR EMBL; JAUUIA010000028; MDP0970194.1; -; Genomic_DNA. DR EMBL; WJVL01000023; MRJ98980.1; -; Genomic_DNA. DR EMBL; WJWF01000039; MRL38647.1; -; Genomic_DNA. DR EMBL; VINI01000024; MSS33672.1; -; Genomic_DNA. DR EMBL; WNPO01000045; MUA42959.1; -; Genomic_DNA. DR EMBL; JAAKYD010000028; NGN75204.1; -; Genomic_DNA. DR EMBL; NDBK01000064; OVF70901.1; -; Genomic_DNA. DR EMBL; MSYX01000010; OWA82504.1; -; Genomic_DNA. DR EMBL; NCMJ01000054; PLE27793.1; -; Genomic_DNA. DR EMBL; PCFF01000001; PVU64335.1; -; Genomic_DNA. DR EMBL; CP055517; QLO17737.1; -; Genomic_DNA. DR EMBL; CP063008; QOU52670.1; -; Genomic_DNA. DR EMBL; CP066534; QQL33013.1; -; Genomic_DNA. DR EMBL; CP068602; QQZ72456.1; -; Genomic_DNA. DR EMBL; QOUB01000001; RCJ54523.1; -; Genomic_DNA. DR EMBL; QRCD01000011; RDT88972.1; -; Genomic_DNA. DR EMBL; MPYG04000255; ROG84450.1; -; Genomic_DNA. DR EMBL; RDAM01000001; RRF06376.1; -; Genomic_DNA. DR EMBL; SGOL01000007; RZG38655.1; -; Genomic_DNA. DR EMBL; FLDK01000005; SBH13745.1; -; Genomic_DNA. DR EMBL; UASO01000004; SQC22324.1; -; Genomic_DNA. DR EMBL; UAWQ01000018; SQC45359.1; -; Genomic_DNA. DR EMBL; UFEU01000002; SSK22593.1; -; Genomic_DNA. DR EMBL; UGKT01000001; STT06328.1; -; Genomic_DNA. DR EMBL; UGLC01000002; STT56586.1; -; Genomic_DNA. DR EMBL; UGLH01000006; STT81935.1; -; Genomic_DNA. DR EMBL; UGLJ01000002; STT95675.1; -; Genomic_DNA. DR EMBL; UGLQ01000003; STU29063.1; -; Genomic_DNA. DR EMBL; UGMD01000002; STV03030.1; -; Genomic_DNA. DR EMBL; UGMG01000001; STV33488.1; -; Genomic_DNA. DR EMBL; UGMN01000004; STV51837.1; -; Genomic_DNA. DR EMBL; UIUC01000001; SVN62221.1; -; Genomic_DNA. DR EMBL; UJHH01000010; SWF72294.1; -; Genomic_DNA. DR EMBL; UJRG01000003; SWT11023.1; -; Genomic_DNA. DR EMBL; UKAW01000002; SXG11045.1; -; Genomic_DNA. DR EMBL; UKGE01000006; SXN30647.1; -; Genomic_DNA. DR EMBL; UKRD01000008; SYC20720.1; -; Genomic_DNA. DR EMBL; UKUT01000004; SYH31270.1; -; Genomic_DNA. DR EMBL; ULCI01000006; SYR35506.1; -; Genomic_DNA. DR EMBL; ULET01000019; SYU76819.1; -; Genomic_DNA. DR EMBL; VSSY01000003; TYL81586.1; -; Genomic_DNA. DR EMBL; UWVH01000001; VCV76643.1; -; Genomic_DNA. DR EMBL; UWWS01000001; VCX96258.1; -; Genomic_DNA. DR EMBL; LR134162; VEB02248.1; -; Genomic_DNA. DR EMBL; CAAHAW010000002; VGJ15405.1; -; Genomic_DNA. DR EMBL; CAAHCC010000014; VGL14206.1; -; Genomic_DNA. DR RefSeq; WP_004144729.1; NZ_WYAM01000011.1. DR GeneID; 64293635; -. DR KEGG; kpb:FH42_12590; -. DR KEGG; kpne:KU54_004475; -. DR KEGG; kpnu:LI86_04480; -. DR KEGG; kpx:PMK1_00810; -. DR OMA; QAFWYLI; -. DR Proteomes; UP000031820; Unassembled WGS sequence. DR Proteomes; UP000052969; Unassembled WGS sequence. DR Proteomes; UP000077826; Unassembled WGS sequence. DR Proteomes; UP000195348; Unassembled WGS sequence. DR Proteomes; UP000196447; Unassembled WGS sequence. DR Proteomes; UP000234439; Unassembled WGS sequence. DR Proteomes; UP000245817; Unassembled WGS sequence. DR Proteomes; UP000250675; Unassembled WGS sequence. DR Proteomes; UP000251721; Unassembled WGS sequence. DR Proteomes; UP000252603; Unassembled WGS sequence. DR Proteomes; UP000253135; Unassembled WGS sequence. DR Proteomes; UP000254103; Unassembled WGS sequence. DR Proteomes; UP000254340; Unassembled WGS sequence. DR Proteomes; UP000254387; Unassembled WGS sequence. DR Proteomes; UP000254680; Unassembled WGS sequence. DR Proteomes; UP000254799; Unassembled WGS sequence. DR Proteomes; UP000255137; Unassembled WGS sequence. DR Proteomes; UP000255192; Unassembled WGS sequence. DR Proteomes; UP000255239; Unassembled WGS sequence. DR Proteomes; UP000255518; Unassembled WGS sequence. DR Proteomes; UP000257587; Unassembled WGS sequence. DR Proteomes; UP000258232; Unassembled WGS sequence. DR Proteomes; UP000258253; Unassembled WGS sequence. DR Proteomes; UP000258673; Unassembled WGS sequence. DR Proteomes; UP000258798; Unassembled WGS sequence. DR Proteomes; UP000258905; Unassembled WGS sequence. DR Proteomes; UP000259364; Unassembled WGS sequence. DR Proteomes; UP000259417; Unassembled WGS sequence. DR Proteomes; UP000259975; Unassembled WGS sequence. DR Proteomes; UP000269921; Unassembled WGS sequence. DR Proteomes; UP000275975; Unassembled WGS sequence. DR Proteomes; UP000278966; Unassembled WGS sequence. DR Proteomes; UP000282433; Chromosome 1. DR Proteomes; UP000283322; Unassembled WGS sequence. DR Proteomes; UP000293472; Unassembled WGS sequence. DR Proteomes; UP000295133; Unassembled WGS sequence. DR Proteomes; UP000322977; Unassembled WGS sequence. DR Proteomes; UP000376235; Unassembled WGS sequence. DR Proteomes; UP000439817; Chromosome. DR Proteomes; UP000441029; Unassembled WGS sequence. DR Proteomes; UP000468995; Unassembled WGS sequence. DR Proteomes; UP000479475; Unassembled WGS sequence. DR Proteomes; UP000485085; Unassembled WGS sequence. DR Proteomes; UP000512241; Chromosome. DR Proteomes; UP000532829; Chromosome. DR Proteomes; UP000595568; Chromosome. DR Proteomes; UP000622626; Unassembled WGS sequence. DR Proteomes; UP001244490; Unassembled WGS sequence. DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule. DR GO; GO:0009037; F:tyrosine-based site-specific recombinase activity; IEA:UniProtKB-UniRule. DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW. DR GO; GO:0007059; P:chromosome segregation; IEA:UniProtKB-UniRule. DR GO; GO:0006313; P:DNA transposition; IEA:UniProtKB-UniRule. DR CDD; cd00798; INT_XerDC_C; 1. DR FunFam; 1.10.150.130:FF:000002; Tyrosine recombinase XerD; 1. DR FunFam; 1.10.443.10:FF:000001; Tyrosine recombinase XerD; 1. DR Gene3D; 1.10.150.130; -; 1. DR Gene3D; 1.10.443.10; Intergrase catalytic core; 1. DR HAMAP; MF_01808; Recomb_XerC_XerD; 1. DR HAMAP; MF_01807; Recomb_XerD; 1. DR InterPro; IPR044068; CB. DR InterPro; IPR011010; DNA_brk_join_enz. DR InterPro; IPR013762; Integrase-like_cat_sf. DR InterPro; IPR002104; Integrase_catalytic. DR InterPro; IPR010998; Integrase_recombinase_N. DR InterPro; IPR004107; Integrase_SAM-like_N. DR InterPro; IPR011932; Recomb_XerD. DR InterPro; IPR023009; Tyrosine_recombinase_XerC/XerD. DR InterPro; IPR050090; Tyrosine_recombinase_XerCD. DR NCBIfam; NF040815; recomb_XerA_Arch; 1. DR NCBIfam; TIGR02225; recomb_XerD; 1. DR PANTHER; PTHR30349; PHAGE INTEGRASE-RELATED; 1. DR PANTHER; PTHR30349:SF87; PROPHAGE INTEGRASE INTD-RELATED; 1. DR Pfam; PF02899; Phage_int_SAM_1; 1. DR Pfam; PF00589; Phage_integrase; 1. DR SUPFAM; SSF56349; DNA breaking-rejoining enzymes; 1. DR PROSITE; PS51900; CB; 1. DR PROSITE; PS51898; TYR_RECOMBINASE; 1. PE 3: Inferred from homology; KW Cell cycle {ECO:0000256|ARBA:ARBA00023306, ECO:0000256|HAMAP- KW Rule:MF_01807}; KW Cell division {ECO:0000256|ARBA:ARBA00022618, ECO:0000256|HAMAP- KW Rule:MF_01807}; KW Chromosome partition {ECO:0000256|ARBA:ARBA00022829, ECO:0000256|HAMAP- KW Rule:MF_01807}; KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490, ECO:0000256|HAMAP-Rule:MF_01807}; KW DNA integration {ECO:0000256|ARBA:ARBA00022908, ECO:0000256|HAMAP- KW Rule:MF_01807}; KW DNA recombination {ECO:0000256|ARBA:ARBA00023172, ECO:0000256|HAMAP- KW Rule:MF_01807}; KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|HAMAP- KW Rule:MF_01807}. FT DOMAIN 2..87 FT /note="Core-binding (CB)" FT /evidence="ECO:0000259|PROSITE:PS51900" FT DOMAIN 108..292 FT /note="Tyr recombinase" FT /evidence="ECO:0000259|PROSITE:PS51898" FT ACT_SITE 148 FT /evidence="ECO:0000256|HAMAP-Rule:MF_01807" FT ACT_SITE 172 FT /evidence="ECO:0000256|HAMAP-Rule:MF_01807" FT ACT_SITE 244 FT /evidence="ECO:0000256|HAMAP-Rule:MF_01807" FT ACT_SITE 247 FT /evidence="ECO:0000256|HAMAP-Rule:MF_01807" FT ACT_SITE 270 FT /evidence="ECO:0000256|HAMAP-Rule:MF_01807" FT ACT_SITE 279 FT /note="O-(3'-phospho-DNA)-tyrosine intermediate" FT /evidence="ECO:0000256|HAMAP-Rule:MF_01807" SQ SEQUENCE 298 AA; 33967 MW; DF893A2E8C2D2B88 CRC64; MKQDLALIEQ FLDALWLERN LAENTLSAYR RDLTMLVEWL HHRGLSLASV GSDDLQALLA ERQSGGYKAT STARLLSAVR RFFQHLYREK IRPDDPSALL ASPKLPQRLP KDLSEAQVER LLQAPLVEQP LELRDKAMLE VLYATGLRVS ELVGLTMSDI SLRQGVLRVV GKGNKERLVP LGEEAVLWVE NYLEYGRPWL LNGVASDVLF PSQRAQQMTR QTFWHRIKHY AVLAGIDSEK LSPHVLRHAF ATHLLNHGAD LRVVQMLLGH SDLSTTQIYT HVATERLRQL HQQHHPRA //