ID A0A060VEM3_KLEPN Unreviewed; 298 AA. AC A0A060VEM3; A0A0J2FNU8; A0A4V0H0I6; DT 03-SEP-2014, integrated into UniProtKB/TrEMBL. DT 03-SEP-2014, sequence version 1. DT 24-JAN-2024, entry version 81. DE RecName: Full=Tyrosine recombinase XerD {ECO:0000256|ARBA:ARBA00015810, ECO:0000256|HAMAP-Rule:MF_01807}; GN Name=xerD_1 {ECO:0000313|EMBL:SXN30647.1}; GN Synonyms=xerD {ECO:0000256|HAMAP-Rule:MF_01807, GN ECO:0000313|EMBL:MDH8287315.1}, xerD_2 {ECO:0000313|EMBL:SQC22324.1}, GN xerD_3 {ECO:0000313|EMBL:STT81935.1}, xerD_4 GN {ECO:0000313|EMBL:STT06328.1}; GN ORFNames=B5L96_14520 {ECO:0000313|EMBL:OVF70901.1}, B6I55_25545 GN {ECO:0000313|EMBL:PLD44050.1}, B6I68_10345 GN {ECO:0000313|EMBL:PLE27793.1}, BANRA_00859 GN {ECO:0000313|EMBL:VCX96258.1}, BB784_04440 GN {ECO:0000313|EMBL:APP51253.1}, BL124_00033500 GN {ECO:0000313|EMBL:ROG84450.1}, CK244_014795 GN {ECO:0000313|EMBL:QBH44143.1}, DL426_23215 GN {ECO:0000313|EMBL:QDX73227.1}, DRB10_12790 GN {ECO:0000313|EMBL:RBN23667.1}, DW281_12810 GN {ECO:0000313|EMBL:RDT88972.1}, EAO17_09240 GN {ECO:0000313|EMBL:RRF06376.1}, EGK12_24725 GN {ECO:0000313|EMBL:RRZ19352.1}, FXN67_05480 GN {ECO:0000313|EMBL:TYL81586.1}, G4V31_24215 GN {ECO:0000313|EMBL:NGN75204.1}, G7Z27_04690 GN {ECO:0000313|EMBL:QLI07111.1}, GJJ08_004405 GN {ECO:0000313|EMBL:QOU52670.1}, GJJ13_003985 GN {ECO:0000313|EMBL:QOU79515.1}, GJJ18_24915 GN {ECO:0000313|EMBL:MRL38647.1}, GJJ26_003970 GN {ECO:0000313|EMBL:QOU26366.1}, GNF00_24250 GN {ECO:0000313|EMBL:MUA42959.1}, GS419_04655 GN {ECO:0000313|EMBL:QHD73497.1}, HC139_10735 GN {ECO:0000313|EMBL:NJK03573.1}, HJX03_04040 GN {ECO:0000313|EMBL:QJL27772.1}, NCTC11679_00882 GN {ECO:0000313|EMBL:STV33488.1}, NCTC13443_06275 GN {ECO:0000313|EMBL:STT06328.1}, NCTC13465_03909 GN {ECO:0000313|EMBL:SQC45359.1}, NCTC13635_02708 GN {ECO:0000313|EMBL:VEB02248.1}, NCTC204_03084 GN {ECO:0000313|EMBL:STV03030.1}, NCTC5047_02873 GN {ECO:0000313|EMBL:STT81935.1}, NCTC5052_04183 GN {ECO:0000313|EMBL:STT95675.1}, NCTC5053_05258 GN {ECO:0000313|EMBL:STV51837.1}, NCTC8849_05245 GN {ECO:0000313|EMBL:STT56586.1}, NCTC9645_02901 GN {ECO:0000313|EMBL:SQC22324.1}, NCTC9661_01619 GN {ECO:0000313|EMBL:STU29063.1}, QIG75_01690 GN {ECO:0000313|EMBL:MDH8287315.1}, SAMEA3499874_00840 GN {ECO:0000313|EMBL:SXG11045.1}, SAMEA3499901_01654 GN {ECO:0000313|EMBL:SXN30647.1}, SAMEA3512100_02307 GN {ECO:0000313|EMBL:SXU32816.1}, SAMEA3515122_02164 GN {ECO:0000313|EMBL:SYH31270.1}, SAMEA3538658_00101 GN {ECO:0000313|EMBL:SYK74791.1}, SAMEA3538828_01629 GN {ECO:0000313|EMBL:SYR35506.1}, SAMEA3720909_02519 GN {ECO:0000313|EMBL:SWF72294.1}, SAMEA3721128_01022 GN {ECO:0000313|EMBL:SWG47736.1}, SAMEA3721197_01922 GN {ECO:0000313|EMBL:SWJ09575.1}, SAMEA3727667_04798 GN {ECO:0000313|EMBL:SWQ63466.1}, SAMEA3727687_02710 GN {ECO:0000313|EMBL:SWR93259.1}, SAMEA3727701_01958 GN {ECO:0000313|EMBL:SWU59272.1}, SAMEA4364603_00912 GN {ECO:0000313|EMBL:SSK22593.1}, SAMEA4370542_04943 GN {ECO:0000313|EMBL:SLS94225.1}, SAMEA4873597_01096 GN {ECO:0000313|EMBL:VGJ15405.1}, SAMEA4873632_04892 GN {ECO:0000313|EMBL:VGL14206.1}, VKR_00828 GN {ECO:0000313|EMBL:CAH1461287.1}; OS Klebsiella pneumoniae. OC Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; OC Enterobacteriaceae; Klebsiella/Raoultella group; Klebsiella. OX NCBI_TaxID=573 {ECO:0000313|EMBL:SXN30647.1, ECO:0000313|Proteomes:UP000259975}; RN [1] {ECO:0000313|EMBL:APP51253.1, ECO:0000313|Proteomes:UP000184679} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Kp_Goe_827024 {ECO:0000313|EMBL:APP51253.1, RC ECO:0000313|Proteomes:UP000184679}; RA Bohne W., Bunk B., Overmann J., Gross U., Zautner A.E.; RT "A nosocomial outbreak of oxa48-expressing Klebsialla pneumoniae in Lower RT Saxony."; RL Submitted (DEC-2016) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Proteomes:UP000234439, ECO:0000313|Proteomes:UP000234595} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=COL-Kpn17 {ECO:0000313|EMBL:PLD44050.1, RC ECO:0000313|Proteomes:UP000234595}, and COL-Kpn30 RC {ECO:0000313|EMBL:PLE27793.1, ECO:0000313|Proteomes:UP000234439}; RX PubMed=29029188; DOI=.1093/infdis/jix524; RA Rojas L.J., Weinstock G.M., De La Cadena E., Diaz L., Rios R., Hanson B.M., RA Brown J.S., Vats P., Phillips D.S., Nguyen H., Hujer K.M., Correa A., RA Adams M.D., Perez F., Sodergren E., Narechania A., Planet P.J., RA Villegas M.V., Bonomo R.A., Arias C.A.; RT "An Analysis of the Epidemic of Klebsiella pneumoniae Carbapenemase- RT Producing K. pneumoniae: Convergence of Two Evolutionary Mechanisms Creates RT the "Perfect Storm"."; RL J. Infect. Dis. 217:82-92(2017). RN [3] {ECO:0000313|EMBL:OVF70901.1, ECO:0000313|Proteomes:UP000196447} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=39383 {ECO:0000313|EMBL:OVF70901.1, RC ECO:0000313|Proteomes:UP000196447}; RA Fouts D., Stalin M.J., Chen L., Wright M., Sutton G., Nguyen K., RA Vanduin D., Rojas L., Hujer A., Hujer K., Bonomo R., Kreiswirth B., RA Adams M.; RL Submitted (MAR-2017) to the EMBL/GenBank/DDBJ databases. RN [4] {ECO:0000313|EMBL:RRF06376.1, ECO:0000313|Proteomes:UP000275975} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=KLPN_104 {ECO:0000313|EMBL:RRF06376.1, RC ECO:0000313|Proteomes:UP000275975}; RX PubMed=30373801; RA Tamma P.D., Fan Y., Bergman Y., Pertea G., Kazmi A., Lewis S., RA Carroll K.C., Schatz M.C., Timp W., Simner P.J.; RT "Applying Rapid Whole Genome Sequencing to Predict Phenotypic Antimicrobial RT Susceptibility Testing Results Among Carbapenem-Resistant Klebsiella RT pneumoniae Clinical Isolates."; RL Antimicrob. Agents Chemother. 0:0-0(2018). RN [5] {ECO:0000313|EMBL:RBN23667.1, ECO:0000313|Proteomes:UP000252982} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=WJQ205 {ECO:0000313|EMBL:RBN23667.1, RC ECO:0000313|Proteomes:UP000252982}; RA Sun Q., Gu D., Hu Y., Shu L., Hu J., Zhang R., Chen G.; RT "Colonization of different clones of blaKPC-2-bearing Klebsiella pneumoniae RT in the gastrointestinal tract."; RL Submitted (JUN-2018) to the EMBL/GenBank/DDBJ databases. RN [6] {ECO:0000313|EMBL:QDX73227.1, ECO:0000313|Proteomes:UP000320592} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=DA12090 {ECO:0000313|EMBL:QDX73227.1, RC ECO:0000313|Proteomes:UP000320592}; RA Sandegren L.; RT "Genome sequence of Klebsiella pneumoniae DA12090 (CAS55)."; RL Submitted (JUN-2018) to the EMBL/GenBank/DDBJ databases. RN [7] {ECO:0000313|Proteomes:UP000250675, ECO:0000313|Proteomes:UP000251721} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=NCTC11679 {ECO:0000313|EMBL:STV33488.1, RC ECO:0000313|Proteomes:UP000255239}, NCTC13443 RC {ECO:0000313|EMBL:STT06328.1, ECO:0000313|Proteomes:UP000255518}, RC NCTC13465 {ECO:0000313|EMBL:SQC45359.1, RC ECO:0000313|Proteomes:UP000251721}, NCTC204 RC {ECO:0000313|EMBL:STV03030.1, ECO:0000313|Proteomes:UP000255192}, RC NCTC5047 {ECO:0000313|EMBL:STT81935.1, RC ECO:0000313|Proteomes:UP000254340}, NCTC5052 RC {ECO:0000313|EMBL:STT95675.1, ECO:0000313|Proteomes:UP000254103}, RC NCTC5053 {ECO:0000313|EMBL:STV51837.1, RC ECO:0000313|Proteomes:UP000254387}, NCTC8849 RC {ECO:0000313|EMBL:STT56586.1, ECO:0000313|Proteomes:UP000254799}, RC NCTC9645 {ECO:0000313|EMBL:SQC22324.1, RC ECO:0000313|Proteomes:UP000250675}, and NCTC9661 RC {ECO:0000313|EMBL:STU29063.1, ECO:0000313|Proteomes:UP000255137}; RG Pathogen Informatics; RA Doyle S.; RL Submitted (JUN-2018) to the EMBL/GenBank/DDBJ databases. RN [8] {ECO:0000313|EMBL:RDT88972.1, ECO:0000313|Proteomes:UP000254680} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=K280 {ECO:0000313|EMBL:RDT88972.1, RC ECO:0000313|Proteomes:UP000254680}; RA He F.; RT "Draft genome sequence of Klebsiella pneumoniae K280."; RL Submitted (JUL-2018) to the EMBL/GenBank/DDBJ databases. RN [9] {ECO:0000313|Proteomes:UP000257410, ECO:0000313|Proteomes:UP000257587} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=4300STDY6470422 {ECO:0000313|EMBL:SSK22593.1, RC ECO:0000313|Proteomes:UP000252603}, 5012STDY7626396 RC {ECO:0000313|EMBL:VGJ15405.1, ECO:0000313|Proteomes:UP000295133}, RC 5012STDY7626430 {ECO:0000313|EMBL:VGL14206.1, RC ECO:0000313|Proteomes:UP000376235}, EuSCAPE_AT002 RC {ECO:0000313|EMBL:SXG11045.1, ECO:0000313|Proteomes:UP000257587}, RC EuSCAPE_AT029 {ECO:0000313|EMBL:SXN30647.1, RC ECO:0000313|Proteomes:UP000259975}, EuSCAPE_BE080 RC {ECO:0000313|EMBL:SWQ63466.1, ECO:0000313|Proteomes:UP000260463}, RC EuSCAPE_BE100 {ECO:0000313|EMBL:SWR93259.1, RC ECO:0000313|Proteomes:UP000259946}, EuSCAPE_BE105 RC {ECO:0000313|EMBL:SWU59272.1, ECO:0000313|Proteomes:UP000257410}, RC EuSCAPE_DE072 {ECO:0000313|EMBL:SXU32816.1, RC ECO:0000313|Proteomes:UP000259753}, EuSCAPE_HR098 RC {ECO:0000313|EMBL:SWG47736.1, ECO:0000313|Proteomes:UP000259884}, RC EuSCAPE_HU047 {ECO:0000313|EMBL:SYR35506.1, RC ECO:0000313|Proteomes:UP000258253}, EuSCAPE_IT093 RC {ECO:0000313|EMBL:SYH31270.1, ECO:0000313|Proteomes:UP000258673}, RC EuSCAPE_IT290 {ECO:0000313|EMBL:SYK74791.1, RC ECO:0000313|Proteomes:UP000258808}, EuSCAPE_RS077 RC {ECO:0000313|EMBL:SWJ09575.1, ECO:0000313|Proteomes:UP000259548}, RC EuSCAPE_UK014 {ECO:0000313|EMBL:SWF72294.1, RC ECO:0000313|Proteomes:UP000259364}, NCTC13635 RC {ECO:0000313|EMBL:VEB02248.1, ECO:0000313|Proteomes:UP000282433}, and RC VRES1272 {ECO:0000313|EMBL:SLS94225.1, RC ECO:0000313|Proteomes:UP000191996}; RG Pathogen Informatics; RL Submitted (AUG-2018) to the EMBL/GenBank/DDBJ databases. RN [10] {ECO:0000313|EMBL:RRZ19352.1, ECO:0000313|Proteomes:UP000279324} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=KP_121 {ECO:0000313|EMBL:RRZ19352.1, RC ECO:0000313|Proteomes:UP000279324}; RA D'Souza A.W., Potter R.F., Wallace M., Shupe A., Patel S., Sun S., Gul D., RA Kwon J.H., Andleeb S., Burnham C.-A.D., Dantas G.; RT "Transmission dynamics of multidrug resistant bacteria on intensive care RT unit surfaces."; RL Submitted (OCT-2018) to the EMBL/GenBank/DDBJ databases. RN [11] {ECO:0000313|EMBL:VCX96258.1, ECO:0000313|Proteomes:UP000278966} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Kpneu025 {ECO:0000313|EMBL:VCX96258.1}; RA Noll B N.; RL Submitted (OCT-2018) to the EMBL/GenBank/DDBJ databases. RN [12] {ECO:0000313|EMBL:ROG84450.1, ECO:0000313|Proteomes:UP000283322} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=CRK0165 {ECO:0000313|EMBL:ROG84450.1, RC ECO:0000313|Proteomes:UP000283322}; RA Vanduin D., Fouts D., Wright M., Sutton G., Nguyen K., Kreiswirth B., RA Chen L., Rojas L., Hujer A., Hujer K., Bonomo R., Adams M.; RL Submitted (OCT-2018) to the EMBL/GenBank/DDBJ databases. RN [13] {ECO:0000313|EMBL:QBH44143.1, ECO:0000313|Proteomes:UP000218354} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=VBA2172 {ECO:0000313|EMBL:QBH44143.1, RC ECO:0000313|Proteomes:UP000218354}; RA Veeraraghavan B., Shankar C., Vasudevan K., Venkatesan M., Narasimman V.; RT "VBA2172 Klebsiella pneumoniae hybrid assembly."; RL Submitted (FEB-2019) to the EMBL/GenBank/DDBJ databases. RN [14] {ECO:0000313|EMBL:TYL81586.1, ECO:0000313|Proteomes:UP000322977} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=UCO-494 {ECO:0000313|EMBL:TYL81586.1, RC ECO:0000313|Proteomes:UP000322977}; RA Morales-Leon F., Caro C., Opazo-Capurro A., Lincopan N., RA Dominguez-Yevenes M., Lima C., Bello-Toledo H., Gonzalez-Rocha G.; RT "Phenotypic and genetic characterization of extended-spectrum b-lactamase- RT producing hypermucoviscous Klebsiella pneumoniae from Chile."; RL Submitted (AUG-2019) to the EMBL/GenBank/DDBJ databases. RN [15] {ECO:0000313|EMBL:MRL38647.1} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=CriePir115 {ECO:0000313|EMBL:MRL38647.1}; RA Shelenkov A., Mikhaylova Y., Yanushevich Y., Samoilov A., Petrova L., RA Fomina V., Gusarov V., Zamyatin M., Shagin D.; RT "Molecular typing, antibiotic resistance determination and virulence RT profiling for 36 multidrug-resistant clinical Klebsiella pneumoniae RT isolates using second- and third-generation sequencing."; RL Submitted (OCT-2019) to the EMBL/GenBank/DDBJ databases. RN [16] {ECO:0000313|EMBL:MUA42959.1, ECO:0000313|Proteomes:UP000485085} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=KP_38044 {ECO:0000313|EMBL:MUA42959.1, RC ECO:0000313|Proteomes:UP000485085}; RA Zhou K.; RT "Emergence of a novel subclone of carbapenem-resistant Klebsiella RT pneumoniae ST11 with enhanced virulence and transmissibility: a molecular RT epidemiological, clinical, genomic study."; RL Submitted (NOV-2019) to the EMBL/GenBank/DDBJ databases. RN [17] {ECO:0000313|EMBL:QHD73497.1, ECO:0000313|Proteomes:UP000464108} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Kp36 {ECO:0000313|EMBL:QHD73497.1, RC ECO:0000313|Proteomes:UP000464108}; RA Tan D.; RT "Mobile Genetic Element-Mediated Frameshifting in wcaJ Provides Phage RT Resistance in Klebsiella pneumoniae."; RL Submitted (DEC-2019) to the EMBL/GenBank/DDBJ databases. RN [18] {ECO:0000313|Proteomes:UP000438340, ECO:0000313|Proteomes:UP000439817} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=CriePir120 {ECO:0000313|EMBL:QOU52670.1, RC ECO:0000313|Proteomes:UP000439817}, CriePir26 RC {ECO:0000313|EMBL:QOU26366.1}, and CriePir45 RC {ECO:0000313|EMBL:QOU79515.1, ECO:0000313|Proteomes:UP000438340}; RX PubMed=32429555; RA Shelenkov A., Mikhaylova Y., Yanushevich Y., Samoilov A., Petrova L., RA Fomina V., Gusarov V., Zamyatin M., Shagin D., Akimkin V.; RT "Molecular Typing, Characterization of Antimicrobial Resistance, Virulence RT Profiling and Analysis of Whole-Genome Sequence of Clinical Klebsiella RT pneumoniae Isolates."; RL Antibiotics 9:E261-E261(2020). RN [19] {ECO:0000313|EMBL:NGN75204.1, ECO:0000313|Proteomes:UP000479475} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=2429 {ECO:0000313|EMBL:NGN75204.1, RC ECO:0000313|Proteomes:UP000479475}; RA Starkova P.S., Sulyan O.S., Likholetova D.V., Ageevets V.A., Lazareva I.V., RA Sopova J.V., Sidorenko S.V.; RT "Klebsiella pneumoniae genome sequencing and assembly."; RL Submitted (FEB-2020) to the EMBL/GenBank/DDBJ databases. RN [20] {ECO:0000313|EMBL:QLI07111.1, ECO:0000313|Proteomes:UP000509467} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=11KM256 {ECO:0000313|EMBL:QLI07111.1, RC ECO:0000313|Proteomes:UP000509467}; RA Brilhante M., Perreten V.; RT "Whole genome sequencing of global problem clones of OXA-48-producing RT Klebsiella pneumoniae from the veterinary setting in Switzerland."; RL Submitted (FEB-2020) to the EMBL/GenBank/DDBJ databases. RN [21] {ECO:0000313|EMBL:NJK03573.1, ECO:0000313|Proteomes:UP000551791} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=UMB8492 {ECO:0000313|EMBL:NJK03573.1, RC ECO:0000313|Proteomes:UP000551791}; RA Miller-Ensminger T., Wolfe A.J., Putonti C.; RT "Draft genome sequences of bacterial isolates from the female urobiome."; RL Submitted (MAR-2020) to the EMBL/GenBank/DDBJ databases. RN [22] {ECO:0000313|EMBL:QJL27772.1, ECO:0000313|Proteomes:UP000503203} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=C16KP0122 {ECO:0000313|EMBL:QJL27772.1, RC ECO:0000313|Proteomes:UP000503203}; RA Yoon E.-J., Gwon B., Liu C., Kim D., Won D., Park S.G., Choi J.R., RA Jeong S.H.; RT "Built-in CTX-M extended-spectrum beta-lactamase gene in Klebsiella RT pneumoniae ensuring stable propagation of the multidrug-resistant pathogen RT in clinical settings."; RL Submitted (APR-2020) to the EMBL/GenBank/DDBJ databases. RN [23] {ECO:0000313|EMBL:CAH1461287.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=BB1542 {ECO:0000313|EMBL:CAH1461287.1}; RA Delgado-Blas J.; RL Submitted (JAN-2022) to the EMBL/GenBank/DDBJ databases. RN [24] {ECO:0000313|EMBL:MDH8287315.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=Sgh23 {ECO:0000313|EMBL:MDH8287315.1}; RA Chen Y., Gan Y.-H.; RT "WGS of Klebsiella strains from the Antibiotics for Klebsiella Liver RT Abscess Syndrome Study (A-KLASS) clinical trial, Singapore."; RL Submitted (APR-2023) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Site-specific tyrosine recombinase, which acts by catalyzing CC the cutting and rejoining of the recombining DNA molecules. Binds CC cooperatively to specific DNA consensus sequences that are separated CC from XerC binding sites by a short central region, forming the CC heterotetrameric XerC-XerD complex that recombines DNA substrates. The CC complex is essential to convert dimers of the bacterial chromosome into CC monomers to permit their segregation at cell division. It also CC contributes to the segregational stability of plasmids. In the complex CC XerD specifically exchanges the bottom DNA strands. {ECO:0000256|HAMAP- CC Rule:MF_01807}. CC -!- ACTIVITY REGULATION: FtsK may regulate the catalytic switch between CC XerC and XerD in the heterotetrameric complex during the two steps of CC the recombination process. {ECO:0000256|HAMAP-Rule:MF_01807}. CC -!- SUBUNIT: Forms a cyclic heterotetrameric complex composed of two CC molecules of XerC and two molecules of XerD, in which XerC interacts CC with XerD via its C-terminal region, XerD interacts with XerC via its CC C-terminal region and so on. {ECO:0000256|ARBA:ARBA00011483, CC ECO:0000256|HAMAP-Rule:MF_01807}. CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496, CC ECO:0000256|HAMAP-Rule:MF_01807}. CC -!- SIMILARITY: Belongs to the 'phage' integrase family. XerD subfamily. CC {ECO:0000256|ARBA:ARBA00010450, ECO:0000256|HAMAP-Rule:MF_01807}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; CP018701; APP51253.1; -; Genomic_DNA. DR EMBL; OV753987; CAH1461287.1; -; Genomic_DNA. DR EMBL; JARYWG010000002; MDH8287315.1; -; Genomic_DNA. DR EMBL; WJWF01000039; MRL38647.1; -; Genomic_DNA. DR EMBL; WNPO01000045; MUA42959.1; -; Genomic_DNA. DR EMBL; JAAKYD010000028; NGN75204.1; -; Genomic_DNA. DR EMBL; JAAUVU010000010; NJK03573.1; -; Genomic_DNA. DR EMBL; NDBK01000064; OVF70901.1; -; Genomic_DNA. DR EMBL; NCLW01000059; PLD44050.1; -; Genomic_DNA. DR EMBL; NCMJ01000054; PLE27793.1; -; Genomic_DNA. DR EMBL; CP036320; QBH44143.1; -; Genomic_DNA. DR EMBL; CP030072; QDX73227.1; -; Genomic_DNA. DR EMBL; CP047192; QHD73497.1; -; Genomic_DNA. DR EMBL; CP052431; QJL27772.1; -; Genomic_DNA. DR EMBL; CP049716; QLI07111.1; -; Genomic_DNA. DR EMBL; CP062986; QOU26366.1; -; Genomic_DNA. DR EMBL; CP063008; QOU52670.1; -; Genomic_DNA. DR EMBL; CP063023; QOU79515.1; -; Genomic_DNA. DR EMBL; QMKD01000011; RBN23667.1; -; Genomic_DNA. DR EMBL; QRCD01000011; RDT88972.1; -; Genomic_DNA. DR EMBL; MPYG04000255; ROG84450.1; -; Genomic_DNA. DR EMBL; RDAM01000001; RRF06376.1; -; Genomic_DNA. DR EMBL; RHTZ01000023; RRZ19352.1; -; Genomic_DNA. DR EMBL; FWJM01000022; SLS94225.1; -; Genomic_DNA. DR EMBL; UASO01000004; SQC22324.1; -; Genomic_DNA. DR EMBL; UAWQ01000018; SQC45359.1; -; Genomic_DNA. DR EMBL; UFEU01000002; SSK22593.1; -; Genomic_DNA. DR EMBL; UGKT01000001; STT06328.1; -; Genomic_DNA. DR EMBL; UGLC01000002; STT56586.1; -; Genomic_DNA. DR EMBL; UGLH01000006; STT81935.1; -; Genomic_DNA. DR EMBL; UGLJ01000002; STT95675.1; -; Genomic_DNA. DR EMBL; UGLQ01000003; STU29063.1; -; Genomic_DNA. DR EMBL; UGMD01000002; STV03030.1; -; Genomic_DNA. DR EMBL; UGMG01000001; STV33488.1; -; Genomic_DNA. DR EMBL; UGMN01000004; STV51837.1; -; Genomic_DNA. DR EMBL; UJHH01000010; SWF72294.1; -; Genomic_DNA. DR EMBL; UJHY01000003; SWG47736.1; -; Genomic_DNA. DR EMBL; UJJV01000004; SWJ09575.1; -; Genomic_DNA. DR EMBL; UJPJ01000021; SWQ63466.1; -; Genomic_DNA. DR EMBL; UJQI01000010; SWR93259.1; -; Genomic_DNA. DR EMBL; UJSE01000004; SWU59272.1; -; Genomic_DNA. DR EMBL; UKAW01000002; SXG11045.1; -; Genomic_DNA. DR EMBL; UKGE01000006; SXN30647.1; -; Genomic_DNA. DR EMBL; UKLK01000004; SXU32816.1; -; Genomic_DNA. DR EMBL; UKUT01000004; SYH31270.1; -; Genomic_DNA. DR EMBL; UKXO01000001; SYK74791.1; -; Genomic_DNA. DR EMBL; ULCI01000006; SYR35506.1; -; Genomic_DNA. DR EMBL; VSSY01000003; TYL81586.1; -; Genomic_DNA. DR EMBL; UWWS01000001; VCX96258.1; -; Genomic_DNA. DR EMBL; LR134162; VEB02248.1; -; Genomic_DNA. DR EMBL; CAAHAW010000002; VGJ15405.1; -; Genomic_DNA. DR EMBL; CAAHCC010000014; VGL14206.1; -; Genomic_DNA. DR RefSeq; WP_004144729.1; NZ_WWEY01000150.1. DR GeneID; 64293635; -. DR KEGG; kpb:FH42_12590; -. DR KEGG; kpne:KU54_004475; -. DR KEGG; kpnu:LI86_04480; -. DR KEGG; kpx:PMK1_00810; -. DR OMA; QAFWYLI; -. DR Proteomes; UP000184679; Chromosome. DR Proteomes; UP000191996; Unassembled WGS sequence. DR Proteomes; UP000196447; Unassembled WGS sequence. DR Proteomes; UP000218354; Chromosome. DR Proteomes; UP000234439; Unassembled WGS sequence. DR Proteomes; UP000234595; Unassembled WGS sequence. DR Proteomes; UP000250675; Unassembled WGS sequence. DR Proteomes; UP000251721; Unassembled WGS sequence. DR Proteomes; UP000252603; Unassembled WGS sequence. DR Proteomes; UP000252982; Unassembled WGS sequence. DR Proteomes; UP000254103; Unassembled WGS sequence. DR Proteomes; UP000254340; Unassembled WGS sequence. DR Proteomes; UP000254387; Unassembled WGS sequence. DR Proteomes; UP000254680; Unassembled WGS sequence. DR Proteomes; UP000254799; Unassembled WGS sequence. DR Proteomes; UP000255137; Unassembled WGS sequence. DR Proteomes; UP000255192; Unassembled WGS sequence. DR Proteomes; UP000255239; Unassembled WGS sequence. DR Proteomes; UP000255518; Unassembled WGS sequence. DR Proteomes; UP000257410; Unassembled WGS sequence. DR Proteomes; UP000257587; Unassembled WGS sequence. DR Proteomes; UP000258253; Unassembled WGS sequence. DR Proteomes; UP000258673; Unassembled WGS sequence. DR Proteomes; UP000258808; Unassembled WGS sequence. DR Proteomes; UP000259364; Unassembled WGS sequence. DR Proteomes; UP000259548; Unassembled WGS sequence. DR Proteomes; UP000259753; Unassembled WGS sequence. DR Proteomes; UP000259884; Unassembled WGS sequence. DR Proteomes; UP000259946; Unassembled WGS sequence. DR Proteomes; UP000259975; Unassembled WGS sequence. DR Proteomes; UP000260463; Unassembled WGS sequence. DR Proteomes; UP000275975; Unassembled WGS sequence. DR Proteomes; UP000278966; Unassembled WGS sequence. DR Proteomes; UP000279324; Unassembled WGS sequence. DR Proteomes; UP000282433; Chromosome 1. DR Proteomes; UP000283322; Unassembled WGS sequence. DR Proteomes; UP000295133; Unassembled WGS sequence. DR Proteomes; UP000320592; Chromosome. DR Proteomes; UP000322977; Unassembled WGS sequence. DR Proteomes; UP000376235; Unassembled WGS sequence. DR Proteomes; UP000438340; Chromosome. DR Proteomes; UP000439817; Chromosome. DR Proteomes; UP000464108; Chromosome. DR Proteomes; UP000479475; Unassembled WGS sequence. DR Proteomes; UP000485085; Unassembled WGS sequence. DR Proteomes; UP000487173; Chromosome. DR Proteomes; UP000503203; Chromosome. DR Proteomes; UP000509467; Chromosome. DR Proteomes; UP000551791; Unassembled WGS sequence. DR Proteomes; UP001157099; Unassembled WGS sequence. DR Proteomes; UP001158595; Chromosome. DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule. DR GO; GO:0009037; F:tyrosine-based site-specific recombinase activity; IEA:UniProtKB-UniRule. DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW. DR GO; GO:0007059; P:chromosome segregation; IEA:UniProtKB-UniRule. DR GO; GO:0006313; P:DNA transposition; IEA:UniProtKB-UniRule. DR CDD; cd00798; INT_XerDC_C; 1. DR Gene3D; 1.10.150.130; -; 1. DR Gene3D; 1.10.443.10; Intergrase catalytic core; 1. DR HAMAP; MF_01808; Recomb_XerC_XerD; 1. DR HAMAP; MF_01807; Recomb_XerD; 1. DR InterPro; IPR044068; CB. DR InterPro; IPR011010; DNA_brk_join_enz. DR InterPro; IPR013762; Integrase-like_cat_sf. DR InterPro; IPR002104; Integrase_catalytic. DR InterPro; IPR010998; Integrase_recombinase_N. DR InterPro; IPR004107; Integrase_SAM-like_N. DR InterPro; IPR011932; Recomb_XerD. DR InterPro; IPR023009; Tyrosine_recombinase_XerC/XerD. DR NCBIfam; TIGR02225; recomb_XerD; 1. DR PANTHER; PTHR30349; PHAGE INTEGRASE-RELATED; 1. DR PANTHER; PTHR30349:SF81; TYROSINE RECOMBINASE XERD; 1. DR Pfam; PF02899; Phage_int_SAM_1; 1. DR Pfam; PF00589; Phage_integrase; 1. DR SUPFAM; SSF56349; DNA breaking-rejoining enzymes; 1. DR PROSITE; PS51900; CB; 1. DR PROSITE; PS51898; TYR_RECOMBINASE; 1. PE 3: Inferred from homology; KW Cell cycle {ECO:0000256|ARBA:ARBA00023306, ECO:0000256|HAMAP- KW Rule:MF_01807}; KW Cell division {ECO:0000256|ARBA:ARBA00022618, ECO:0000256|HAMAP- KW Rule:MF_01807}; KW Chromosome partition {ECO:0000256|ARBA:ARBA00022829, ECO:0000256|HAMAP- KW Rule:MF_01807}; KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490, ECO:0000256|HAMAP-Rule:MF_01807}; KW DNA integration {ECO:0000256|ARBA:ARBA00022908, ECO:0000256|HAMAP- KW Rule:MF_01807}; KW DNA recombination {ECO:0000256|ARBA:ARBA00023172, ECO:0000256|HAMAP- KW Rule:MF_01807}; KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|HAMAP- KW Rule:MF_01807}. FT DOMAIN 2..87 FT /note="Core-binding (CB)" FT /evidence="ECO:0000259|PROSITE:PS51900" FT DOMAIN 108..292 FT /note="Tyr recombinase" FT /evidence="ECO:0000259|PROSITE:PS51898" FT ACT_SITE 148 FT /evidence="ECO:0000256|HAMAP-Rule:MF_01807" FT ACT_SITE 172 FT /evidence="ECO:0000256|HAMAP-Rule:MF_01807" FT ACT_SITE 244 FT /evidence="ECO:0000256|HAMAP-Rule:MF_01807" FT ACT_SITE 247 FT /evidence="ECO:0000256|HAMAP-Rule:MF_01807" FT ACT_SITE 270 FT /evidence="ECO:0000256|HAMAP-Rule:MF_01807" FT ACT_SITE 279 FT /note="O-(3'-phospho-DNA)-tyrosine intermediate" FT /evidence="ECO:0000256|HAMAP-Rule:MF_01807" SQ SEQUENCE 298 AA; 33967 MW; DF893A2E8C2D2B88 CRC64; MKQDLALIEQ FLDALWLERN LAENTLSAYR RDLTMLVEWL HHRGLSLASV GSDDLQALLA ERQSGGYKAT STARLLSAVR RFFQHLYREK IRPDDPSALL ASPKLPQRLP KDLSEAQVER LLQAPLVEQP LELRDKAMLE VLYATGLRVS ELVGLTMSDI SLRQGVLRVV GKGNKERLVP LGEEAVLWVE NYLEYGRPWL LNGVASDVLF PSQRAQQMTR QTFWHRIKHY AVLAGIDSEK LSPHVLRHAF ATHLLNHGAD LRVVQMLLGH SDLSTTQIYT HVATERLRQL HQQHHPRA //