ID A0A060VEM3_KLEPN Unreviewed; 298 AA. AC A0A060VEM3; A0A0J2FNU8; A0A4V0H0I6; DT 03-SEP-2014, integrated into UniProtKB/TrEMBL. DT 03-SEP-2014, sequence version 1. DT 07-APR-2021, entry version 68. DE RecName: Full=Tyrosine recombinase XerD {ECO:0000256|ARBA:ARBA00015810, ECO:0000256|HAMAP-Rule:MF_01807}; GN Name=xerD_1 {ECO:0000313|EMBL:SXN30647.1}; GN Synonyms=xerD {ECO:0000256|HAMAP-Rule:MF_01807, GN ECO:0000313|EMBL:AUU96018.1}, xerD_2 {ECO:0000313|EMBL:SQC22324.1}, GN xerD_3 {ECO:0000313|EMBL:STT81935.1}, xerD_4 GN {ECO:0000313|EMBL:STT06328.1}; GN ORFNames=BANRA_01662 {ECO:0000313|EMBL:VCW55188.1}, BANRA_03562 GN {ECO:0000313|EMBL:VCZ44708.1}, BL124_00033500 GN {ECO:0000313|EMBL:ROG84450.1}, BVX91_20715 GN {ECO:0000313|EMBL:PAX11544.1}, C2U49_15015 GN {ECO:0000313|EMBL:AUU96018.1}, C3F39_19500 GN {ECO:0000313|EMBL:AUY20800.1}, C4Y50_001360 GN {ECO:0000313|EMBL:ROG94080.1}, CK508_011550 GN {ECO:0000313|EMBL:RJS99761.1}, DD581_26750 GN {ECO:0000313|EMBL:RXY83143.1}, DD583_10645 GN {ECO:0000313|EMBL:RXZ11009.1}, DM059_25510 GN {ECO:0000313|EMBL:RCJ95709.1}, DM060_24430 GN {ECO:0000313|EMBL:RCJ90806.1}, EAO17_09240 GN {ECO:0000313|EMBL:RRF06376.1}, EPB11_26880 GN {ECO:0000313|EMBL:QHQ45820.1}, EXT45_09365 GN {ECO:0000313|EMBL:RZG38655.1}, FXN67_05480 GN {ECO:0000313|EMBL:TYL81586.1}, G5637_06420 GN {ECO:0000313|EMBL:NGE18388.1}, G7Z27_04690 GN {ECO:0000313|EMBL:QLI07111.1}, GF489_04285 GN {ECO:0000313|EMBL:MRD85777.1}, HV294_03965 GN {ECO:0000313|EMBL:QLT27262.1}, NCTC11679_00882 GN {ECO:0000313|EMBL:STV33488.1}, NCTC13443_06275 GN {ECO:0000313|EMBL:STT06328.1}, NCTC13465_03909 GN {ECO:0000313|EMBL:SQC45359.1}, NCTC13635_02708 GN {ECO:0000313|EMBL:VEB02248.1}, NCTC1936_04966 GN {ECO:0000313|EMBL:STT68740.1}, NCTC204_03084 GN {ECO:0000313|EMBL:STV03030.1}, NCTC5047_02873 GN {ECO:0000313|EMBL:STT81935.1}, NCTC5052_04183 GN {ECO:0000313|EMBL:STT95675.1}, NCTC5053_05258 GN {ECO:0000313|EMBL:STV51837.1}, NCTC8849_05245 GN {ECO:0000313|EMBL:STT56586.1}, NCTC9645_02901 GN {ECO:0000313|EMBL:SQC22324.1}, NCTC9661_01619 GN {ECO:0000313|EMBL:STU29063.1}, SAMEA24002668_05251 GN {ECO:0000313|EMBL:SSF86199.1}, SAMEA3499901_01654 GN {ECO:0000313|EMBL:SXN30647.1}, SAMEA3649466_02574 GN {ECO:0000313|EMBL:SVM85449.1}, SAMEA3673122_01102 GN {ECO:0000313|EMBL:SWE21563.1}, SAMEA3727579_04546 GN {ECO:0000313|EMBL:SWO21437.1}, SAMEA3727679_00425 GN {ECO:0000313|EMBL:SWR35885.1}, SAMEA4364603_00912 GN {ECO:0000313|EMBL:SSK22593.1}, SAMEA4873581_02632 GN {ECO:0000313|EMBL:VGI38069.1}, WP4S18C04_07830 GN {ECO:0000313|EMBL:BBR76197.1}; OS Klebsiella pneumoniae. OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales; OC Enterobacteriaceae; Klebsiella. OX NCBI_TaxID=573 {ECO:0000313|EMBL:SXN30647.1, ECO:0000313|Proteomes:UP000259975}; RN [1] {ECO:0000313|EMBL:PAX11544.1, ECO:0000313|Proteomes:UP000218240} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=WBB417 {ECO:0000313|EMBL:PAX11544.1, RC ECO:0000313|Proteomes:UP000218240}; RA Koh T.H., Abdul Rahman N., Teo J.W., La M.-V., Periaswamy B., Chen S.L.; RT "Draft Genome Sequence of a Singapore Klebsiella pneumoniae subsp. RT pnuemoniae isolate DS32358_14 Encoding the Carbapenemase Gene blaVIM-1."; RL Submitted (SEP-2017) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|EMBL:RRF06376.1, ECO:0000313|Proteomes:UP000275975} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=KLPN_104 {ECO:0000313|EMBL:RRF06376.1, RC ECO:0000313|Proteomes:UP000275975}; RX PubMed=30373801; RA Tamma P.D., Fan Y., Bergman Y., Pertea G., Kazmi A., Lewis S., RA Carroll K.C., Schatz M.C., Timp W., Simner P.J.; RT "Applying Rapid Whole Genome Sequencing to Predict Phenotypic Antimicrobial RT Susceptibility Testing Results Among Carbapenem-Resistant Klebsiella RT pneumoniae Clinical Isolates."; RL Antimicrob. Agents Chemother. 0:0-0(2018). RN [3] {ECO:0000313|Proteomes:UP000236255, ECO:0000313|Proteomes:UP000239813} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=KPNIH48 {ECO:0000313|Proteomes:UP000239813}, and KPNIH49 RC {ECO:0000313|Proteomes:UP000236255}; RX PubMed=29437920; RG NISC Comparative Sequencing Program; RA Weingarten R.A., Johnson R.C., Conlan S., Ramsburg A.M., Dekker J.P., RA Lau A.F., Khil P., Odom R.T., Deming C., Park M., Thomas P.J., RA Henderson D.K., Palmore T.N., Segre J.A., Frank K.M.; RT "Genomic Analysis of Hospital Plumbing Reveals Diverse Reservoir of RT Bacterial Plasmids Conferring Carbapenem Resistance."; RL MBio 9:e02011-e02017(2018). RN [4] {ECO:0000313|EMBL:AUY20800.1} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=KPNIH48 {ECO:0000313|EMBL:AUY20800.1}; RA Weingarten R.A., Johnson R.C., Conlan S., Ramsburg A.M., Dekker J.P., RA Lau A.F., Khil P., Odom R.T., Deming C., Park M., Thomas P.J., RA Henderson D.K., Palmore T.N., Segre J.A., Frank K.M.; RT "Genomic Analysis of Hospital Plumbing Reveals Diverse Reservoir of RT Bacterial Plasmids Conferring Carbapenem Resistance."; RL MBio 0:0-0(2018). RN [5] {ECO:0000313|EMBL:AUU96018.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=KPNIH49 {ECO:0000313|EMBL:AUU96018.1}; RG NISC Comparative Sequencing Program; RA Weingarten R.A., Johnson R.C., Conlan S., Ramsburg A.M., Dekker J.P., RA Lau A.F., Khil P., Odom R.T., Deming C., Park M., Thomas P.J., RA Henderson D.K., Palmore T.N., Segre J.A., Frank K.M.; RT "Genomic Analysis of Hospital Plumbing Reveals Diverse Reservoir of RT Bacterial Plasmids Conferring Carbapenem Resistance."; RL Submitted (JAN-2018) to the EMBL/GenBank/DDBJ databases. RN [6] {ECO:0000313|EMBL:AUU96018.1, ECO:0000313|Proteomes:UP000236255} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=KPNIH49 {ECO:0000313|EMBL:AUU96018.1, RC ECO:0000313|Proteomes:UP000236255}; RA Segre J.A., Mullikin J.; RL Submitted (JAN-2018) to the EMBL/GenBank/DDBJ databases. RN [7] {ECO:0000313|EMBL:RXY83143.1, ECO:0000313|Proteomes:UP000289252, ECO:0000313|Proteomes:UP000290276} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=3DZ2-3B {ECO:0000313|EMBL:RXY83143.1, RC ECO:0000313|Proteomes:UP000290276}, and 775-DZ2-4B RC {ECO:0000313|EMBL:RXZ11009.1, ECO:0000313|Proteomes:UP000289252}; RA Zhang R., Li J., Wang Y., Shen J., Shen Z., Wang S.; RT "The molecular epidemiology of the NDM positive non-E. coli RT Enterobacteriaceae in poultry production environment."; RL Submitted (MAY-2018) to the EMBL/GenBank/DDBJ databases. RN [8] {ECO:0000313|Proteomes:UP000250675, ECO:0000313|Proteomes:UP000251721, ECO:0000313|Proteomes:UP000254103} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=NCTC11679 {ECO:0000313|EMBL:STV33488.1, RC ECO:0000313|Proteomes:UP000255239}, NCTC13443 RC {ECO:0000313|EMBL:STT06328.1, ECO:0000313|Proteomes:UP000255518}, RC NCTC13465 {ECO:0000313|EMBL:SQC45359.1, RC ECO:0000313|Proteomes:UP000251721}, NCTC1936 RC {ECO:0000313|EMBL:STT68740.1, ECO:0000313|Proteomes:UP000254753}, RC NCTC204 {ECO:0000313|EMBL:STV03030.1, RC ECO:0000313|Proteomes:UP000255192}, NCTC5047 RC {ECO:0000313|EMBL:STT81935.1, ECO:0000313|Proteomes:UP000254340}, RC NCTC5052 {ECO:0000313|EMBL:STT95675.1, RC ECO:0000313|Proteomes:UP000254103}, NCTC5053 RC {ECO:0000313|EMBL:STV51837.1, ECO:0000313|Proteomes:UP000254387}, RC NCTC8849 {ECO:0000313|EMBL:STT56586.1, RC ECO:0000313|Proteomes:UP000254799}, NCTC9645 RC {ECO:0000313|EMBL:SQC22324.1, ECO:0000313|Proteomes:UP000250675}, and RC NCTC9661 {ECO:0000313|EMBL:STU29063.1, RC ECO:0000313|Proteomes:UP000255137}; RG Pathogen Informatics; RA Doyle S.; RL Submitted (JUN-2018) to the EMBL/GenBank/DDBJ databases. RN [9] {ECO:0000313|EMBL:RCJ90806.1, ECO:0000313|Proteomes:UP000252755, ECO:0000313|Proteomes:UP000253217} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=BC-4224 {ECO:0000313|EMBL:RCJ90806.1, RC ECO:0000313|Proteomes:UP000252755}, and BC_4223 RC {ECO:0000313|EMBL:RCJ95709.1, ECO:0000313|Proteomes:UP000253217}; RA Martins R.C.R., Perdigao-Neto L.V., Costa S.F., Levin A.S.S.; RT "Klebsiella pneumoniae genome sequencing and assembly."; RL Submitted (JUL-2018) to the EMBL/GenBank/DDBJ databases. RN [10] {ECO:0000313|EMBL:RCJ90806.1, ECO:0000313|Proteomes:UP000252755} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=BC-4224 {ECO:0000313|EMBL:RCJ90806.1, RC ECO:0000313|Proteomes:UP000252755}; RA Martins R.C., Perdigao-Neto L.V., Costa S.F., Levin A.S.S.; RL Submitted (JUL-2018) to the EMBL/GenBank/DDBJ databases. RN [11] {ECO:0000313|EMBL:RCJ95709.1, ECO:0000313|Proteomes:UP000253217} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=BC_4223 {ECO:0000313|EMBL:RCJ95709.1, RC ECO:0000313|Proteomes:UP000253217}; RA Quirk P.G., Krulwich T.A.; RL Submitted (JUL-2018) to the EMBL/GenBank/DDBJ databases. RN [12] {ECO:0000313|Proteomes:UP000257313, ECO:0000313|Proteomes:UP000257792, ECO:0000313|Proteomes:UP000258785} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=4300STDY6470422 {ECO:0000313|EMBL:SSK22593.1, RC ECO:0000313|Proteomes:UP000252603}, 4300STDY6636959 RC {ECO:0000313|EMBL:SSF86199.1, ECO:0000313|Proteomes:UP000253632}, RC 5012STDY7626380 {ECO:0000313|EMBL:VGI38069.1, RC ECO:0000313|Proteomes:UP000390008}, EuSCAPE_AT029 RC {ECO:0000313|EMBL:SXN30647.1, ECO:0000313|Proteomes:UP000259975}, RC EuSCAPE_BE092 {ECO:0000313|EMBL:SWR35885.1, RC ECO:0000313|Proteomes:UP000258785}, EuSCAPE_ES150 RC {ECO:0000313|EMBL:SVM85449.1, ECO:0000313|Proteomes:UP000260067}, RC EuSCAPE_IE029 {ECO:0000313|EMBL:SWO21437.1, RC ECO:0000313|Proteomes:UP000257313}, EuSCAPE_RO021 RC {ECO:0000313|EMBL:SWE21563.1, ECO:0000313|Proteomes:UP000257792}, and RC NCTC13635 {ECO:0000313|EMBL:VEB02248.1, RC ECO:0000313|Proteomes:UP000282433}; RG Pathogen Informatics; RL Submitted (AUG-2018) to the EMBL/GenBank/DDBJ databases. RN [13] {ECO:0000313|EMBL:RJS99761.1, ECO:0000313|Proteomes:UP000218552} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=B35 {ECO:0000313|EMBL:RJS99761.1, RC ECO:0000313|Proteomes:UP000218552}; RA Araujo B.F., Campos P.A., Royer S., Ferreira M.L., Goncalves I.R., RA Batistao D.W.F., Cerdeira L.T., Brito C.S., Gontijo-Filho P., Ribas R.M.; RT "Klebsiella pneumoniae KPC-2-producing B35 strain."; RL Submitted (SEP-2018) to the EMBL/GenBank/DDBJ databases. RN [14] {ECO:0000313|EMBL:ROG94080.1, ECO:0000313|Proteomes:UP000286610} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=CRK0390 {ECO:0000313|EMBL:ROG94080.1, RC ECO:0000313|Proteomes:UP000286610}; RA Vanduin D., Fouts D., Sutton G., Nguyen K., Hujer A., Hujer K., Bonomo R.; RL Submitted (OCT-2018) to the EMBL/GenBank/DDBJ databases. RN [15] {ECO:0000313|EMBL:ROG84450.1, ECO:0000313|Proteomes:UP000283322} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=CRK0165 {ECO:0000313|EMBL:ROG84450.1, RC ECO:0000313|Proteomes:UP000283322}; RA Vanduin D., Fouts D., Wright M., Sutton G., Nguyen K., Kreiswirth B., RA Chen L., Rojas L., Hujer A., Hujer K., Bonomo R., Adams M.; RL Submitted (OCT-2018) to the EMBL/GenBank/DDBJ databases. RN [16] {ECO:0000313|EMBL:VCW55188.1, ECO:0000313|Proteomes:UP000269373, ECO:0000313|Proteomes:UP000277476} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Kpneu014 {ECO:0000313|EMBL:VCW55188.1}, and Kpneu037 RC {ECO:0000313|EMBL:VCZ44708.1}; RA Noll B N.; RL Submitted (OCT-2018) to the EMBL/GenBank/DDBJ databases. RN [17] {ECO:0000313|EMBL:MRD85777.1, ECO:0000313|Proteomes:UP000475774} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=99 {ECO:0000313|EMBL:MRD85777.1, RC ECO:0000313|Proteomes:UP000475774}; RA Paraschiv S., Surleac M., Czobor Barbu I., Popa L.I., Gheorghe I., RA Otelea D., Chifiriuc M.C.; RT "Whole genome sequencing snapshot of multi-drug resistant Klebsiella RT pneumoniae strains from hospitals and receiving wastewater treatment plants RT in Southern Romania."; RL PLoS ONE 0:0-0(2019). RN [18] {ECO:0000313|EMBL:RZG38655.1, ECO:0000313|Proteomes:UP000293472} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=53 {ECO:0000313|EMBL:RZG38655.1, RC ECO:0000313|Proteomes:UP000293472}; RA Newire E., Aydin A., Juma S., Enne V., Roberts A.P.; RT "Identification of a Type IV CRISPR-Cas system located exclusively on RT IncHI1B/ IncFIB plasmids in Enterobacteriaceae."; RL Submitted (FEB-2019) to the EMBL/GenBank/DDBJ databases. RN [19] {ECO:0000313|EMBL:TYL81586.1, ECO:0000313|Proteomes:UP000322977} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=UCO-494 {ECO:0000313|EMBL:TYL81586.1, RC ECO:0000313|Proteomes:UP000322977}; RA Morales-Leon F., Caro C., Opazo-Capurro A., Lincopan N., RA Dominguez-Yevenes M., Lima C., Bello-Toledo H., Gonzalez-Rocha G.; RT "Phenotypic and genetic characterization of extended-spectrum b-lactamase- RT producing hypermucoviscous Klebsiella pneumoniae from Chile."; RL Submitted (AUG-2019) to the EMBL/GenBank/DDBJ databases. RN [20] {ECO:0000313|EMBL:QHQ45820.1, ECO:0000313|Proteomes:UP000465088} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=MRK9 {ECO:0000313|EMBL:QHQ45820.1, RC ECO:0000313|Proteomes:UP000465088}; RA Azam M., Gaind R., Yadav G., Singh R.; RL Submitted (SEP-2019) to the EMBL/GenBank/DDBJ databases. RN [21] {ECO:0000313|EMBL:BBR76197.1, ECO:0000313|Proteomes:UP000515327} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=WP4-S18-CRE-04 {ECO:0000313|EMBL:BBR76197.1, RC ECO:0000313|Proteomes:UP000515327}; RA Sekizuka T., Itokawa K., Yatsu K., Inamine Y., Kuroda M.; RT "complete genome sequences of Klebsiella pneumoniae str. WP4-S18-CRE-04 RT isolated from wastewater treatment plant effluent."; RL Submitted (DEC-2019) to the EMBL/GenBank/DDBJ databases. RN [22] {ECO:0000313|EMBL:NGE18388.1, ECO:0000313|Proteomes:UP000474962} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=KPM_60 {ECO:0000313|EMBL:NGE18388.1, RC ECO:0000313|Proteomes:UP000474962}; RA Tokajian S., El Chaar M., El Khoury M.; RT "WGS of Carbapenem-Resistant Entrobacteriaceae."; RL Submitted (FEB-2020) to the EMBL/GenBank/DDBJ databases. RN [23] {ECO:0000313|EMBL:QLI07111.1, ECO:0000313|Proteomes:UP000509467} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=11KM256 {ECO:0000313|EMBL:QLI07111.1, RC ECO:0000313|Proteomes:UP000509467}; RA Brilhante M., Perreten V.; RT "Whole genome sequencing of global problem clones of OXA-48-producing RT Klebsiella pneumoniae from the veterinary setting in Switzerland."; RL Submitted (FEB-2020) to the EMBL/GenBank/DDBJ databases. RN [24] {ECO:0000313|EMBL:QLT27262.1, ECO:0000313|Proteomes:UP000511940} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=RHBSTW-00843 {ECO:0000313|EMBL:QLT27262.1, RC ECO:0000313|Proteomes:UP000511940}; RA Shaw L.P.; RT "REHAB project genomes."; RL Submitted (JUN-2020) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Site-specific tyrosine recombinase, which acts by catalyzing CC the cutting and rejoining of the recombining DNA molecules. Binds CC cooperatively to specific DNA consensus sequences that are separated CC from XerC binding sites by a short central region, forming the CC heterotetrameric XerC-XerD complex that recombines DNA substrates. The CC complex is essential to convert dimers of the bacterial chromosome into CC monomers to permit their segregation at cell division. It also CC contributes to the segregational stability of plasmids. In the complex CC XerD specifically exchanges the bottom DNA strands. {ECO:0000256|HAMAP- CC Rule:MF_01807}. CC -!- ACTIVITY REGULATION: FtsK may regulate the catalytic switch between CC XerC and XerD in the heterotetrameric complex during the two steps of CC the recombination process. {ECO:0000256|HAMAP-Rule:MF_01807}. CC -!- SUBUNIT: Forms a cyclic heterotetrameric complex composed of two CC molecules of XerC and two molecules of XerD, in which XerC interacts CC with XerD via its C-terminal region, XerD interacts with XerC via its CC C-terminal region and so on. {ECO:0000256|ARBA:ARBA00011483, CC ECO:0000256|HAMAP-Rule:MF_01807}. CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496, CC ECO:0000256|HAMAP-Rule:MF_01807}. CC -!- SIMILARITY: Belongs to the 'phage' integrase family. XerD subfamily. CC {ECO:0000256|ARBA:ARBA00010450, ECO:0000256|HAMAP-Rule:MF_01807}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; CP026178; AUU96018.1; -; Genomic_DNA. DR EMBL; CP026392; AUY20800.1; -; Genomic_DNA. DR EMBL; AP022078; BBR76197.1; -; Genomic_DNA. DR EMBL; WJBQ01000002; MRD85777.1; -; Genomic_DNA. DR EMBL; JAAJRV010000003; NGE18388.1; -; Genomic_DNA. DR EMBL; NSMB01000014; PAX11544.1; -; Genomic_DNA. DR EMBL; CP043859; QHQ45820.1; -; Genomic_DNA. DR EMBL; CP049716; QLI07111.1; -; Genomic_DNA. DR EMBL; CP056301; QLT27262.1; -; Genomic_DNA. DR EMBL; QOUF01000707; RCJ90806.1; -; Genomic_DNA. DR EMBL; QOUG01001467; RCJ95709.1; -; Genomic_DNA. DR EMBL; NTHY02000039; RJS99761.1; -; Genomic_DNA. DR EMBL; MPYG04000255; ROG84450.1; -; Genomic_DNA. DR EMBL; PTFF02000005; ROG94080.1; -; Genomic_DNA. DR EMBL; RDAM01000001; RRF06376.1; -; Genomic_DNA. DR EMBL; QFMH01000384; RXY83143.1; -; Genomic_DNA. DR EMBL; QFMF01000008; RXZ11009.1; -; Genomic_DNA. DR EMBL; SGOL01000007; RZG38655.1; -; Genomic_DNA. DR EMBL; UASO01000004; SQC22324.1; -; Genomic_DNA. DR EMBL; UAWQ01000018; SQC45359.1; -; Genomic_DNA. DR EMBL; UFBE01000027; SSF86199.1; -; Genomic_DNA. DR EMBL; UFEU01000002; SSK22593.1; -; Genomic_DNA. DR EMBL; UGKT01000001; STT06328.1; -; Genomic_DNA. DR EMBL; UGLC01000002; STT56586.1; -; Genomic_DNA. DR EMBL; UGLI01000001; STT68740.1; -; Genomic_DNA. DR EMBL; UGLH01000006; STT81935.1; -; Genomic_DNA. DR EMBL; UGLJ01000002; STT95675.1; -; Genomic_DNA. DR EMBL; UGLQ01000003; STU29063.1; -; Genomic_DNA. DR EMBL; UGMD01000002; STV03030.1; -; Genomic_DNA. DR EMBL; UGMG01000001; STV33488.1; -; Genomic_DNA. DR EMBL; UGMN01000004; STV51837.1; -; Genomic_DNA. DR EMBL; UITM01000007; SVM85449.1; -; Genomic_DNA. DR EMBL; UJGH01000002; SWE21563.1; -; Genomic_DNA. DR EMBL; UJNP01000022; SWO21437.1; -; Genomic_DNA. DR EMBL; UJPY01000001; SWR35885.1; -; Genomic_DNA. DR EMBL; UKGE01000006; SXN30647.1; -; Genomic_DNA. DR EMBL; VSSY01000003; TYL81586.1; -; Genomic_DNA. DR EMBL; UWVV01000001; VCW55188.1; -; Genomic_DNA. DR EMBL; UWXT01000001; VCZ44708.1; -; Genomic_DNA. DR EMBL; LR134162; VEB02248.1; -; Genomic_DNA. DR EMBL; CAAHAF010000004; VGI38069.1; -; Genomic_DNA. DR RefSeq; WP_004144729.1; NZ_WYAM01000011.1. DR EnsemblBacteria; AIT00307; AIT00307; PMK1_00810. DR EnsemblBacteria; AUY20800; AUY20800; C3F39_19500. DR EnsemblBacteria; AVB70589; AVB70589; C3483_04075. DR EnsemblBacteria; KLY12001; KLY12001; SK89_04359. DR EnsemblBacteria; OON35129; OON35129; BU230_34595. DR EnsemblBacteria; PAX11544; PAX11544; BVX91_20715. DR EnsemblBacteria; PPK23654; PPK23654; CSC88_13350. DR EnsemblBacteria; PWF56157; PWF56157; C7V41_27010. DR EnsemblBacteria; RCJ95709; RCJ95709; DM059_25510. DR EnsemblBacteria; RDT68825; RDT68825; DXF97_06455. DR EnsemblBacteria; SBX92074; SBX92074; SAMEA3531848_02889. DR EnsemblBacteria; SQC22324; SQC22324; NCTC9645_02901. DR EnsemblBacteria; SQC45359; SQC45359; NCTC13465_03909. DR EnsemblBacteria; SSF57305; SSF57305; SAMEA23986918_01179. DR EnsemblBacteria; SSF86199; SSF86199; SAMEA24002668_05251. DR EnsemblBacteria; SSK22593; SSK22593; SAMEA4364603_00912. DR EnsemblBacteria; STT06328; STT06328; NCTC13443_06275. DR EnsemblBacteria; STT56586; STT56586; NCTC8849_05245. DR EnsemblBacteria; STT68740; STT68740; NCTC1936_04966. DR EnsemblBacteria; STT81935; STT81935; NCTC5047_02873. DR EnsemblBacteria; STT95675; STT95675; NCTC5052_04183. DR EnsemblBacteria; STU29063; STU29063; NCTC9661_01619. DR EnsemblBacteria; STV03030; STV03030; NCTC204_03084. DR EnsemblBacteria; STV33488; STV33488; NCTC11679_00882. DR EnsemblBacteria; STV51837; STV51837; NCTC5053_05258. DR EnsemblBacteria; SVJ39266; SVJ39266; SAMEA4394730_02526. DR EnsemblBacteria; VEB02248; VEB02248; NCTC13635_02708. DR GeneID; 56978264; -. DR KEGG; kpb:FH42_12590; -. DR KEGG; kpne:KU54_004475; -. DR KEGG; kpnu:LI86_04480; -. DR KEGG; kpx:PMK1_00810; -. DR OrthoDB; 745068at2; -. DR Proteomes; UP000218240; Unassembled WGS sequence. DR Proteomes; UP000218552; Unassembled WGS sequence. DR Proteomes; UP000236255; Chromosome. DR Proteomes; UP000239813; Chromosome. DR Proteomes; UP000250675; Unassembled WGS sequence. DR Proteomes; UP000251721; Unassembled WGS sequence. DR Proteomes; UP000252603; Unassembled WGS sequence. DR Proteomes; UP000252755; Unassembled WGS sequence. DR Proteomes; UP000253217; Unassembled WGS sequence. DR Proteomes; UP000253632; Unassembled WGS sequence. DR Proteomes; UP000254103; Unassembled WGS sequence. DR Proteomes; UP000254340; Unassembled WGS sequence. DR Proteomes; UP000254387; Unassembled WGS sequence. DR Proteomes; UP000254753; Unassembled WGS sequence. DR Proteomes; UP000254799; Unassembled WGS sequence. DR Proteomes; UP000255137; Unassembled WGS sequence. DR Proteomes; UP000255192; Unassembled WGS sequence. DR Proteomes; UP000255239; Unassembled WGS sequence. DR Proteomes; UP000255518; Unassembled WGS sequence. DR Proteomes; UP000257313; Unassembled WGS sequence. DR Proteomes; UP000257792; Unassembled WGS sequence. DR Proteomes; UP000258785; Unassembled WGS sequence. DR Proteomes; UP000259975; Unassembled WGS sequence. DR Proteomes; UP000260067; Unassembled WGS sequence. DR Proteomes; UP000269373; Unassembled WGS sequence. DR Proteomes; UP000275975; Unassembled WGS sequence. DR Proteomes; UP000277476; Unassembled WGS sequence. DR Proteomes; UP000282433; Chromosome 1. DR Proteomes; UP000283322; Unassembled WGS sequence. DR Proteomes; UP000286610; Unassembled WGS sequence. DR Proteomes; UP000289252; Unassembled WGS sequence. DR Proteomes; UP000290276; Unassembled WGS sequence. DR Proteomes; UP000293472; Unassembled WGS sequence. DR Proteomes; UP000322977; Unassembled WGS sequence. DR Proteomes; UP000390008; Unassembled WGS sequence. DR Proteomes; UP000465088; Chromosome. DR Proteomes; UP000474962; Unassembled WGS sequence. DR Proteomes; UP000475774; Unassembled WGS sequence. DR Proteomes; UP000509467; Chromosome. DR Proteomes; UP000511940; Chromosome. DR Proteomes; UP000515327; Chromosome. DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule. DR GO; GO:0009037; F:tyrosine-based site-specific recombinase activity; IEA:UniProtKB-UniRule. DR GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW. DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW. DR GO; GO:0007059; P:chromosome segregation; IEA:UniProtKB-UniRule. DR GO; GO:0006313; P:transposition, DNA-mediated; IEA:UniProtKB-UniRule. DR Gene3D; 1.10.150.130; -; 1. DR Gene3D; 1.10.443.10; -; 1. DR HAMAP; MF_01808; Recomb_XerC_XerD; 1. DR HAMAP; MF_01807; Recomb_XerD; 1. DR InterPro; IPR044068; CB. DR InterPro; IPR011010; DNA_brk_join_enz. DR InterPro; IPR013762; Integrase-like_cat_sf. DR InterPro; IPR002104; Integrase_catalytic. DR InterPro; IPR010998; Integrase_recombinase_N. DR InterPro; IPR004107; Integrase_SAM-like_N. DR InterPro; IPR011932; Recomb_XerD. DR InterPro; IPR023009; Tyrosine_recombinase_XerC/XerD. DR Pfam; PF02899; Phage_int_SAM_1; 1. DR Pfam; PF00589; Phage_integrase; 1. DR SUPFAM; SSF56349; SSF56349; 1. DR TIGRFAMs; TIGR02225; recomb_XerD; 1. DR PROSITE; PS51900; CB; 1. DR PROSITE; PS51898; TYR_RECOMBINASE; 1. PE 3: Inferred from homology; KW Cell cycle {ECO:0000256|ARBA:ARBA00023306, ECO:0000256|HAMAP- KW Rule:MF_01807}; KW Cell division {ECO:0000256|ARBA:ARBA00022618, ECO:0000256|HAMAP- KW Rule:MF_01807}; KW Chromosome partition {ECO:0000256|ARBA:ARBA00022829, ECO:0000256|HAMAP- KW Rule:MF_01807}; KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490, ECO:0000256|HAMAP-Rule:MF_01807}; KW DNA integration {ECO:0000256|ARBA:ARBA00022908, ECO:0000256|HAMAP- KW Rule:MF_01807}; KW DNA recombination {ECO:0000256|ARBA:ARBA00023172, ECO:0000256|HAMAP- KW Rule:MF_01807}; KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|HAMAP- KW Rule:MF_01807, ECO:0000256|PROSITE-ProRule:PRU01248}. FT DOMAIN 2..87 FT /note="Core-binding (CB)" FT /evidence="ECO:0000259|PROSITE:PS51900" FT DOMAIN 108..292 FT /note="Tyr recombinase" FT /evidence="ECO:0000259|PROSITE:PS51898" FT ACT_SITE 148 FT /evidence="ECO:0000256|HAMAP-Rule:MF_01807" FT ACT_SITE 172 FT /evidence="ECO:0000256|HAMAP-Rule:MF_01807" FT ACT_SITE 244 FT /evidence="ECO:0000256|HAMAP-Rule:MF_01807" FT ACT_SITE 247 FT /evidence="ECO:0000256|HAMAP-Rule:MF_01807" FT ACT_SITE 270 FT /evidence="ECO:0000256|HAMAP-Rule:MF_01807" FT ACT_SITE 279 FT /note="O-(3'-phospho-DNA)-tyrosine intermediate" FT /evidence="ECO:0000256|HAMAP-Rule:MF_01807" SQ SEQUENCE 298 AA; 33967 MW; DF893A2E8C2D2B88 CRC64; MKQDLALIEQ FLDALWLERN LAENTLSAYR RDLTMLVEWL HHRGLSLASV GSDDLQALLA ERQSGGYKAT STARLLSAVR RFFQHLYREK IRPDDPSALL ASPKLPQRLP KDLSEAQVER LLQAPLVEQP LELRDKAMLE VLYATGLRVS ELVGLTMSDI SLRQGVLRVV GKGNKERLVP LGEEAVLWVE NYLEYGRPWL LNGVASDVLF PSQRAQQMTR QTFWHRIKHY AVLAGIDSEK LSPHVLRHAF ATHLLNHGAD LRVVQMLLGH SDLSTTQIYT HVATERLRQL HQQHHPRA //