ID A0A060VEM3_KLEPN Unreviewed; 298 AA. AC A0A060VEM3; A0A0J2FNU8; DT 03-SEP-2014, integrated into UniProtKB/TrEMBL. DT 03-SEP-2014, sequence version 1. DT 26-FEB-2020, entry version 61. DE RecName: Full=Tyrosine recombinase XerD {ECO:0000256|HAMAP-Rule:MF_01807}; GN Name=xerD_1 {ECO:0000313|EMBL:SBX92074.1}; GN Synonyms=xerD {ECO:0000256|HAMAP-Rule:MF_01807, GN ECO:0000313|EMBL:AUY20800.1}, xerD_2 {ECO:0000313|EMBL:SQC22324.1}, GN xerD_3 {ECO:0000313|EMBL:STT81935.1}, xerD_4 GN {ECO:0000313|EMBL:STT06328.1}; GN ORFNames=B4U61_19045 {ECO:0000313|EMBL:TEA99473.1}, BANRA_03562 GN {ECO:0000313|EMBL:VCZ44708.1}, BL124_00033500 GN {ECO:0000313|EMBL:ROG84450.1}, BVX91_20715 GN {ECO:0000313|EMBL:PAX11544.1}, C1459_08995 GN {ECO:0000313|EMBL:TAI78213.1}, C2D59_04110 GN {ECO:0000313|EMBL:QFY32265.1}, C2D61_04315 GN {ECO:0000313|EMBL:QFY26850.1}, C3F39_19500 GN {ECO:0000313|EMBL:AUY20800.1}, C4Y50_001360 GN {ECO:0000313|EMBL:ROG94080.1}, C7V41_27010 GN {ECO:0000313|EMBL:PWF56157.1}, C8P71_4754 GN {ECO:0000313|EMBL:RMB23049.1}, DD581_26750 GN {ECO:0000313|EMBL:RXY83143.1}, DD583_10645 GN {ECO:0000313|EMBL:RXZ11009.1}, DM059_25510 GN {ECO:0000313|EMBL:RCJ95709.1}, EAO17_09240 GN {ECO:0000313|EMBL:RRF06376.1}, EPO92_09775 GN {ECO:0000313|EMBL:QFU49638.1}, EQH49_02105 GN {ECO:0000313|EMBL:QFU58271.1}, EQH51_24700 GN {ECO:0000313|EMBL:QFU72742.1}, EXT45_09365 GN {ECO:0000313|EMBL:RZG38655.1}, F0330_09235 GN {ECO:0000313|EMBL:KAA0486132.1}, F1D54_20785 GN {ECO:0000313|EMBL:KAA1498412.1}, F2X40_19405 GN {ECO:0000313|EMBL:QER49598.1}, F3G17_18980 GN {ECO:0000313|EMBL:KAA5741288.1}, F3G25_11040 GN {ECO:0000313|EMBL:KAA5735152.1}, F3P37_08900 GN {ECO:0000313|EMBL:QER80526.1}, FAT93_01500 GN {ECO:0000313|EMBL:THS93593.1}, FCH06_019205 GN {ECO:0000313|EMBL:TYY80925.1}, FJR44_03415 GN {ECO:0000313|EMBL:QEO69576.1}, FM021_04460 GN {ECO:0000313|EMBL:QEX40677.1}, FNY87_24315 GN {ECO:0000313|EMBL:TRW00494.1}, FOB37_21600 GN {ECO:0000313|EMBL:QET21186.1}, FOB38_25235 GN {ECO:0000313|EMBL:QET11398.1}, FOB39_10780 GN {ECO:0000313|EMBL:QET14116.1}, FR744_04370 GN {ECO:0000313|EMBL:QFH94110.1}, FXN67_05480 GN {ECO:0000313|EMBL:TYL81586.1}, GFJ44_04075 GN {ECO:0000313|EMBL:QGA01571.1}, NCTC11679_00882 GN {ECO:0000313|EMBL:STV33488.1}, NCTC13443_06275 GN {ECO:0000313|EMBL:STT06328.1}, NCTC13465_03909 GN {ECO:0000313|EMBL:SQC45359.1}, NCTC13635_02708 GN {ECO:0000313|EMBL:VEB02248.1}, NCTC1936_04966 GN {ECO:0000313|EMBL:STT68740.1}, NCTC204_03084 GN {ECO:0000313|EMBL:STV03030.1}, NCTC5047_02873 GN {ECO:0000313|EMBL:STT81935.1}, NCTC5052_04183 GN {ECO:0000313|EMBL:STT95675.1}, NCTC5053_05258 GN {ECO:0000313|EMBL:STV51837.1}, NCTC8849_05245 GN {ECO:0000313|EMBL:STT56586.1}, NCTC9645_02901 GN {ECO:0000313|EMBL:SQC22324.1}, NCTC9661_01619 GN {ECO:0000313|EMBL:STU29063.1}, SAMEA104567806_02957 GN {ECO:0000313|EMBL:VGD10272.1}, SAMEA104567857_04294 GN {ECO:0000313|EMBL:VGG04295.1}, SAMEA1712935_02683 GN {ECO:0000313|EMBL:VAP98378.1}, SAMEA1712962_02710 GN {ECO:0000313|EMBL:VAQ00471.1}, SAMEA1712987_01233 GN {ECO:0000313|EMBL:VAP03302.1}, SAMEA1713027_02624 GN {ECO:0000313|EMBL:VAP31363.1}, SAMEA1713070_03099 GN {ECO:0000313|EMBL:VAQ13245.1}, SAMEA1713074_03161 GN {ECO:0000313|EMBL:VAP30480.1}, SAMEA2054088_03078 GN {ECO:0000313|EMBL:VAS63989.1}, SAMEA24002668_05251 GN {ECO:0000313|EMBL:SSF86199.1}, SAMEA3531848_02889 GN {ECO:0000313|EMBL:SBX92074.1}, SAMEA3538476_00426 GN {ECO:0000313|EMBL:VVK40169.1}, SAMEA4364603_00912 GN {ECO:0000313|EMBL:SSK22593.1}, SAMEA4873640_04643 GN {ECO:0000313|EMBL:VGL46693.1}, SK89_04359 GN {ECO:0000313|EMBL:KLY12001.1}; OS Klebsiella pneumoniae. OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales; OC Enterobacteriaceae; Klebsiella. OX NCBI_TaxID=573 {ECO:0000313|EMBL:KLY12001.1, ECO:0000313|Proteomes:UP000035995}; RN [1] {ECO:0000313|EMBL:KLY12001.1, ECO:0000313|Proteomes:UP000035995} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=CHS153 {ECO:0000313|EMBL:KLY12001.1, RC ECO:0000313|Proteomes:UP000035995}; RG The Broad Institute Genomics Platform; RG The Broad Institute Genome Sequencing Center for Infectious Disease; RA Earl A.M., Onderdonk A.B., Kirby J., Ferraro M.J., Huang S., Spencer M., RA Fodor A., Hooper D., Dekker J., O'Brien T., Quan V., Gombosev A., RA Delaney M., DuBois A., Ernst C., Kim D.S., Rossman W., Gohs F., Petruso H., RA Nozar T., Mougeot F., Manson-McGuire A., Young S., Abouelleil A., Cao P., RA Chapman S.B., Griggs A., Priest M., Shea T., Wortman I., Wortman J.R., RA Nusbaum C., Birren B.; RT "The Genome Sequence of None."; RL Submitted (JUN-2015) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|EMBL:TEA99473.1, ECO:0000313|Proteomes:UP000297943} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=MEC097 {ECO:0000313|EMBL:TEA99473.1, RC ECO:0000313|Proteomes:UP000297943}; RA Arya A.S.; RT "Isolation of Levoglucosan Utilizing Bacteria."; RL Submitted (MAR-2017) to the EMBL/GenBank/DDBJ databases. RN [3] {ECO:0000313|EMBL:PAX11544.1, ECO:0000313|Proteomes:UP000218240} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=WBB417 {ECO:0000313|EMBL:PAX11544.1, RC ECO:0000313|Proteomes:UP000218240}; RA Koh T.H., Abdul Rahman N., Teo J.W., La M.-V., Periaswamy B., Chen S.L.; RT "Draft Genome Sequence of a Singapore Klebsiella pneumoniae subsp. RT pnuemoniae isolate DS32358_14 Encoding the Carbapenemase Gene blaVIM-1."; RL Submitted (SEP-2017) to the EMBL/GenBank/DDBJ databases. RN [4] {ECO:0000313|EMBL:RRF06376.1, ECO:0000313|Proteomes:UP000275975} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=KLPN_104 {ECO:0000313|EMBL:RRF06376.1, RC ECO:0000313|Proteomes:UP000275975}; RX PubMed=30373801; RA Tamma P.D., Fan Y., Bergman Y., Pertea G., Kazmi A., Lewis S., RA Carroll K.C., Schatz M.C., Timp W., Simner P.J.; RT "Applying Rapid Whole Genome Sequencing to Predict Phenotypic Antimicrobial RT Susceptibility Testing Results Among Carbapenem-Resistant Klebsiella RT pneumoniae Clinical Isolates."; RL Antimicrob. Agents Chemother. 0:0-0(2018). RN [5] {ECO:0000313|Proteomes:UP000239813} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=KPNIH48 {ECO:0000313|Proteomes:UP000239813}; RX PubMed=29437920; RG NISC Comparative Sequencing Program; RA Weingarten R.A., Johnson R.C., Conlan S., Ramsburg A.M., Dekker J.P., RA Lau A.F., Khil P., Odom R.T., Deming C., Park M., Thomas P.J., RA Henderson D.K., Palmore T.N., Segre J.A., Frank K.M.; RT "Genomic Analysis of Hospital Plumbing Reveals Diverse Reservoir of RT Bacterial Plasmids Conferring Carbapenem Resistance."; RL MBio 9:e02011-17(2018). RN [6] {ECO:0000313|EMBL:AUY20800.1} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=KPNIH48 {ECO:0000313|EMBL:AUY20800.1}; RA Weingarten R.A., Johnson R.C., Conlan S., Ramsburg A.M., Dekker J.P., RA Lau A.F., Khil P., Odom R.T., Deming C., Park M., Thomas P.J., RA Henderson D.K., Palmore T.N., Segre J.A., Frank K.M.; RT "Genomic Analysis of Hospital Plumbing Reveals Diverse Reservoir of RT Bacterial Plasmids Conferring Carbapenem Resistance."; RL MBio 0:0-0(2018). RN [7] {ECO:0000313|EMBL:QFY26850.1, ECO:0000313|Proteomes:UP000325416, ECO:0000313|Proteomes:UP000326098} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=11420 {ECO:0000313|EMBL:QFY32265.1, RC ECO:0000313|Proteomes:UP000325416}, and 13190 RC {ECO:0000313|EMBL:QFY26850.1, ECO:0000313|Proteomes:UP000326098}; RA Jia X., Ma G., Zhan Z., Zhou D., Chen F.; RT "Hypervirulent and multidrug-resistant Klebsiella pneumoniae."; RL Submitted (JAN-2018) to the EMBL/GenBank/DDBJ databases. RN [8] {ECO:0000313|EMBL:TAI78213.1, ECO:0000313|Proteomes:UP000292131} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=G702R2B5 {ECO:0000313|EMBL:TAI78213.1, RC ECO:0000313|Proteomes:UP000292131}; RA Allam M.; RT "Whole Genome Sequencing of Extended Spectrum-Beta-lactamases producing RT Klebsiella pneumoniae: Clonal spread of lineage ST 152."; RL Submitted (JAN-2018) to the EMBL/GenBank/DDBJ databases. RN [9] {ECO:0000313|EMBL:PWF56157.1, ECO:0000313|Proteomes:UP000245017} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=KPL0.2 {ECO:0000313|EMBL:PWF56157.1, RC ECO:0000313|Proteomes:UP000245017}; RA Le Guern R., Grandjean T., Bauduin M., Loquet A., Faure K., Kipnis E., RA Dessein R.; RT "A murine model of gut colonization with Klebsiella pneumoniae NDM."; RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases. RN [10] {ECO:0000313|EMBL:RXY83143.1, ECO:0000313|Proteomes:UP000289252, ECO:0000313|Proteomes:UP000290276} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=3DZ2-3B {ECO:0000313|EMBL:RXY83143.1, RC ECO:0000313|Proteomes:UP000290276}, and 775-DZ2-4B RC {ECO:0000313|EMBL:RXZ11009.1, ECO:0000313|Proteomes:UP000289252}; RA Zhang R., Li J., Wang Y., Shen J., Shen Z., Wang S.; RT "The molecular epidemiology of the NDM positive non-E. coli RT Enterobacteriaceae in poultry production environment."; RL Submitted (MAY-2018) to the EMBL/GenBank/DDBJ databases. RN [11] {ECO:0000313|Proteomes:UP000250675, ECO:0000313|Proteomes:UP000251721, ECO:0000313|Proteomes:UP000254103} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=NCTC11679 {ECO:0000313|EMBL:STV33488.1, RC ECO:0000313|Proteomes:UP000255239}, NCTC13443 RC {ECO:0000313|EMBL:STT06328.1, ECO:0000313|Proteomes:UP000255518}, RC NCTC13465 {ECO:0000313|EMBL:SQC45359.1, RC ECO:0000313|Proteomes:UP000251721}, NCTC1936 RC {ECO:0000313|EMBL:STT68740.1, ECO:0000313|Proteomes:UP000254753}, RC NCTC204 {ECO:0000313|EMBL:STV03030.1, RC ECO:0000313|Proteomes:UP000255192}, NCTC5047 RC {ECO:0000313|EMBL:STT81935.1, ECO:0000313|Proteomes:UP000254340}, RC NCTC5052 {ECO:0000313|EMBL:STT95675.1, RC ECO:0000313|Proteomes:UP000254103}, NCTC5053 RC {ECO:0000313|EMBL:STV51837.1, ECO:0000313|Proteomes:UP000254387}, RC NCTC8849 {ECO:0000313|EMBL:STT56586.1, RC ECO:0000313|Proteomes:UP000254799}, NCTC9645 RC {ECO:0000313|EMBL:SQC22324.1, ECO:0000313|Proteomes:UP000250675}, and RC NCTC9661 {ECO:0000313|EMBL:STU29063.1, RC ECO:0000313|Proteomes:UP000255137}; RG Pathogen Informatics; RA Doyle S.; RL Submitted (JUN-2018) to the EMBL/GenBank/DDBJ databases. RN [12] {ECO:0000313|EMBL:RCJ95709.1, ECO:0000313|Proteomes:UP000253217} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=BC_4223 {ECO:0000313|EMBL:RCJ95709.1, RC ECO:0000313|Proteomes:UP000253217}; RA Martins R.C.R., Perdigao-Neto L.V., Costa S.F., Levin A.S.S.; RT "Klebsiella pneumoniae genome sequencing and assembly."; RL Submitted (JUL-2018) to the EMBL/GenBank/DDBJ databases. RN [13] {ECO:0000313|EMBL:RCJ95709.1, ECO:0000313|Proteomes:UP000253217} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=BC_4223 {ECO:0000313|EMBL:RCJ95709.1, RC ECO:0000313|Proteomes:UP000253217}; RA Quirk P.G., Krulwich T.A.; RL Submitted (JUL-2018) to the EMBL/GenBank/DDBJ databases. RN [14] {ECO:0000313|Proteomes:UP000326261, ECO:0000313|Proteomes:UP000326442, ECO:0000313|Proteomes:UP000326581} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=2485STDY5438215 {ECO:0000313|EMBL:VAQ00471.1, RC ECO:0000313|Proteomes:UP000326581}, 2485STDY5438231 RC {ECO:0000313|EMBL:VAQ13245.1, ECO:0000313|Proteomes:UP000327058}, RC 2485STDY5438239 {ECO:0000313|EMBL:VAP98378.1, RC ECO:0000313|Proteomes:UP000327181}, 2485STDY5438246 RC {ECO:0000313|EMBL:VAP31363.1, ECO:0000313|Proteomes:UP000326442}, RC 2485STDY5438277 {ECO:0000313|EMBL:VAP03302.1, RC ECO:0000313|Proteomes:UP000326261}, 2485STDY5438285 RC {ECO:0000313|EMBL:VAP30480.1, ECO:0000313|Proteomes:UP000327175}, RC 2485STDY5477964 {ECO:0000313|EMBL:VAS63989.1, RC ECO:0000313|Proteomes:UP000326989}, 4300STDY6470422 RC {ECO:0000313|EMBL:SSK22593.1, ECO:0000313|Proteomes:UP000252603}, RC 4300STDY6636959 {ECO:0000313|EMBL:SSF86199.1, RC ECO:0000313|Proteomes:UP000253632}, 5012STDY7312591 RC {ECO:0000313|EMBL:VGD10272.1, ECO:0000313|Proteomes:UP000295363}, RC 5012STDY7312675 {ECO:0000313|EMBL:VGG04295.1, RC ECO:0000313|Proteomes:UP000295429}, 5012STDY7626438 RC {ECO:0000313|EMBL:VGL46693.1, ECO:0000313|Proteomes:UP000295084}, RC EuSCAPE_IL018 {ECO:0000313|EMBL:VVK40169.1, RC ECO:0000313|Proteomes:UP000259433}, NCTC13635 RC {ECO:0000313|EMBL:VEB02248.1, ECO:0000313|Proteomes:UP000282433}, and RC PB463 {ECO:0000313|EMBL:SBX92074.1, RC ECO:0000313|Proteomes:UP000092856}; RG Pathogen Informatics; RL Submitted (SEP-2018) to the EMBL/GenBank/DDBJ databases. RN [15] {ECO:0000313|EMBL:RMB23049.1, ECO:0000313|Proteomes:UP000271388} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=JE01 {ECO:0000313|EMBL:RMB23049.1, RC ECO:0000313|Proteomes:UP000271388}; RA Guss A.; RT "PacBio sequencing to determine microbial DNA methylation."; RL Submitted (OCT-2018) to the EMBL/GenBank/DDBJ databases. RN [16] {ECO:0000313|EMBL:ROG94080.1, ECO:0000313|Proteomes:UP000286610} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=CRK0390 {ECO:0000313|EMBL:ROG94080.1, RC ECO:0000313|Proteomes:UP000286610}; RA Vanduin D., Fouts D., Sutton G., Nguyen K., Hujer A., Hujer K., Bonomo R.; RL Submitted (OCT-2018) to the EMBL/GenBank/DDBJ databases. RN [17] {ECO:0000313|EMBL:ROG84450.1, ECO:0000313|Proteomes:UP000283322} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=CRK0165 {ECO:0000313|EMBL:ROG84450.1, RC ECO:0000313|Proteomes:UP000283322}; RA Vanduin D., Fouts D., Wright M., Sutton G., Nguyen K., Kreiswirth B., RA Chen L., Rojas L., Hujer A., Hujer K., Bonomo R., Adams M.; RL Submitted (OCT-2018) to the EMBL/GenBank/DDBJ databases. RN [18] {ECO:0000313|EMBL:VCZ44708.1, ECO:0000313|Proteomes:UP000269373} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Kpneu037 {ECO:0000313|EMBL:VCZ44708.1}; RA Noll B N.; RL Submitted (OCT-2018) to the EMBL/GenBank/DDBJ databases. RN [19] {ECO:0000313|EMBL:QFU49638.1, ECO:0000313|Proteomes:UP000325692} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=LH102-A {ECO:0000313|EMBL:QFU49638.1, RC ECO:0000313|Proteomes:UP000325692}; RA Hadjadj L., Rolain J.-M.; RT "Genome of KpLH102-A."; RL Submitted (JAN-2019) to the EMBL/GenBank/DDBJ databases. RN [20] {ECO:0000313|EMBL:QFU58271.1, ECO:0000313|Proteomes:UP000326754} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=LH94 {ECO:0000313|EMBL:QFU58271.1, RC ECO:0000313|Proteomes:UP000326754}; RA Hadjadj L., Rolain J.-M.; RT "Genome of KpLH94."; RL Submitted (JAN-2019) to the EMBL/GenBank/DDBJ databases. RN [21] {ECO:0000313|EMBL:QFU72742.1, ECO:0000313|Proteomes:UP000326148} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=TH164 {ECO:0000313|EMBL:QFU72742.1, RC ECO:0000313|Proteomes:UP000326148}; RA Hadjadj L., Rolain J.-M.; RT "Genome of KpTH164."; RL Submitted (JAN-2019) to the EMBL/GenBank/DDBJ databases. RN [22] {ECO:0000313|EMBL:RZG38655.1, ECO:0000313|Proteomes:UP000293472} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=53 {ECO:0000313|EMBL:RZG38655.1, RC ECO:0000313|Proteomes:UP000293472}; RA Newire E., Aydin A., Juma S., Enne V., Roberts A.P.; RT "Identification of a Type IV CRISPR-Cas system located exclusively on RT IncHI1B/ IncFIB plasmids in Enterobacteriaceae."; RL Submitted (FEB-2019) to the EMBL/GenBank/DDBJ databases. RN [23] {ECO:0000313|EMBL:THS93593.1, ECO:0000313|Proteomes:UP000305572} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=SIKP198 {ECO:0000313|EMBL:THS93593.1, RC ECO:0000313|Proteomes:UP000305572}; RA Fouts D., Sutton G., Singh I., Nguyen K.; RL Submitted (APR-2019) to the EMBL/GenBank/DDBJ databases. RN [24] {ECO:0000313|EMBL:QEX40677.1, ECO:0000313|Proteomes:UP000326156} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=KP58 {ECO:0000313|EMBL:QEX40677.1, RC ECO:0000313|Proteomes:UP000326156}; RA Ruan Z., He F.; RT "Emergence of a pandrug resistant hypervirulent Klebsiella pneumoniae RT isolate in China."; RL Submitted (JUL-2019) to the EMBL/GenBank/DDBJ databases. RN [25] {ECO:0000313|Proteomes:UP000320855} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=szkp201906 {ECO:0000313|Proteomes:UP000320855}; RA Shen Z., Gao Q., Li M.; RT "Emergence of NDM-5-producing hypervirulent Klebsiella pneumoniae from RT clinical infections."; RL Submitted (JUL-2019) to the EMBL/GenBank/DDBJ databases. RN [26] {ECO:0000313|EMBL:TRW00494.1, ECO:0000313|Proteomes:UP000317393} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=SCPM-O-B-8658 {ECO:0000313|EMBL:TRW00494.1}, and SCPM-O-B-8658 RC (KPB536) {ECO:0000313|Proteomes:UP000317393}; RA Myakinina V., Fursova N., Volozhantsev N., Sizova A., Kislichkina A., RA Bogun A., Mukhina T., Mayskaya N.; RL Submitted (JUL-2019) to the EMBL/GenBank/DDBJ databases. RN [27] {ECO:0000313|EMBL:KAA0486132.1, ECO:0000313|Proteomes:UP000323019} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=K7 {ECO:0000313|EMBL:KAA0486132.1, RC ECO:0000313|Proteomes:UP000323019}; RA Cho G.-S., Stein M., Fiedler G., Igbinosa E.O., Heuermann L., Brinks E., RA Neve H., Franz C.M.A.P.; RT "Characterization of antibiotic-resistant enterobacteria."; RL Submitted (AUG-2019) to the EMBL/GenBank/DDBJ databases. RN [28] {ECO:0000313|EMBL:TYY80925.1, ECO:0000313|Proteomes:UP000323143} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=AS001328 {ECO:0000313|EMBL:TYY80925.1, RC ECO:0000313|Proteomes:UP000323143}; RA Beisken S.; RT "Evaluating DNBSEQ for clinical isolate sequencing and identification of RT antibiotic resistance."; RL Submitted (AUG-2019) to the EMBL/GenBank/DDBJ databases. RN [29] {ECO:0000313|EMBL:QFH94110.1, ECO:0000313|Proteomes:UP000325644} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=C2 {ECO:0000313|EMBL:QFH94110.1, RC ECO:0000313|Proteomes:UP000325644}; RA Phan H.T.T., Stoesser N., Gordon K.A., Crook D., Walker S.A., Mathers A.J., RA Peto T.E.A., George S., Lipworth S.I.; RT "Genomic Dynamics of Species and Mobile Genetic Elements in a Prolonged RT blaIMP-4-associated Carbapenemase Outbreak in an Australian Hospital."; RL Submitted (AUG-2019) to the EMBL/GenBank/DDBJ databases. RN [30] {ECO:0000313|EMBL:TYL81586.1, ECO:0000313|Proteomes:UP000322977} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=UCO-494 {ECO:0000313|EMBL:TYL81586.1, RC ECO:0000313|Proteomes:UP000322977}; RA Morales-Leon F., Caro C., Opazo-Capurro A., Lincopan N., RA Dominguez-Yevenes M., Lima C., Bello-Toledo H., Gonzalez-Rocha G.; RT "Phenotypic and genetic characterization of extended-spectrum b-lactamase- RT producing hypermucoviscous Klebsiella pneumoniae from Chile."; RL Submitted (AUG-2019) to the EMBL/GenBank/DDBJ databases. RN [31] {ECO:0000313|EMBL:QER80526.1, ECO:0000313|Proteomes:UP000323986} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=D1 {ECO:0000313|EMBL:QER80526.1, RC ECO:0000313|Proteomes:UP000323986}; RA Jousset A.B., Bonnin R.A., Takissian J., Glaser P., Dortet L., Naas T.; RT "Concomitant carriage of KPC-producing and non-KPC-producing Klebsiella RT pneumoniae ST512 due to in vivo lost of pKPC."; RL Submitted (SEP-2019) to the EMBL/GenBank/DDBJ databases. RN [32] {ECO:0000313|EMBL:QEO69576.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=RJY9645 {ECO:0000313|EMBL:QEO69576.1}; RA Shen Z., Gao Q., Li M.; RT "Emergence of NDM-5-producing hypervirulent Klebsiella pneumoniae from RT clinical infections."; RL Submitted (SEP-2019) to the EMBL/GenBank/DDBJ databases. RN [33] {ECO:0000313|Proteomes:UP000322263, ECO:0000313|Proteomes:UP000324565, ECO:0000313|Proteomes:UP000324621} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=FDAARGOS_629 {ECO:0000313|EMBL:QET21186.1, RC ECO:0000313|Proteomes:UP000322263}, FDAARGOS_630 RC {ECO:0000313|EMBL:QET11398.1, ECO:0000313|Proteomes:UP000324621}, and RC FDAARGOS_631 {ECO:0000313|EMBL:QET14116.1, RC ECO:0000313|Proteomes:UP000324565}; RA Bachman M., Young C., Tallon L., Sadzewicz L., Vavikolanu K., Mehta A., RA Aluvathingal J., Nadendla S., Nandy P., Geyer C., Yan Y., Sichtig H.; RT "FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): RT Supporting development and validation of Infectious Disease Dx tests."; RL Submitted (SEP-2019) to the EMBL/GenBank/DDBJ databases. RN [34] {ECO:0000313|Proteomes:UP000322675, ECO:0000313|Proteomes:UP000322831} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=P12 {ECO:0000313|Proteomes:UP000322675}, and P23 RC {ECO:0000313|Proteomes:UP000322831}; RA Zhang X.; RT "Genome of bacteria."; RL Submitted (SEP-2019) to the EMBL/GenBank/DDBJ databases. RN [35] {ECO:0000313|EMBL:QER49598.1, ECO:0000313|Proteomes:UP000324100} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=555 {ECO:0000313|EMBL:QER49598.1, RC ECO:0000313|Proteomes:UP000324100}; RA Rong X.; RT "Klebsiella pneumoniae 555 carrying blaNDM-5 gene isolated from chicken RT farms in China."; RL Submitted (SEP-2019) to the EMBL/GenBank/DDBJ databases. RN [36] {ECO:0000313|EMBL:KAA1498412.1, ECO:0000313|Proteomes:UP000322821} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=195D9 {ECO:0000313|EMBL:KAA1498412.1, RC ECO:0000313|Proteomes:UP000322821}; RA Bonnin R.A., Jousset A.B., Chiarelli A., Emeraud C., Glaser P., Naas T., RA Dortet L.; RT "Unexpected genetic diversity among KPC-producing Klebsiella in France."; RL Submitted (SEP-2019) to the EMBL/GenBank/DDBJ databases. RN [37] {ECO:0000313|EMBL:KAA5735152.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=P12 {ECO:0000313|EMBL:KAA5741288.1}, and P23 RC {ECO:0000313|EMBL:KAA5735152.1}; RA Zhang X.; RL Submitted (SEP-2019) to the EMBL/GenBank/DDBJ databases. RN [38] {ECO:0000313|EMBL:QGA01571.1, ECO:0000313|Proteomes:UP000325646} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=SMU18037509 {ECO:0000313|EMBL:QGA01571.1, RC ECO:0000313|Proteomes:UP000325646}; RA Imai K.; RT "A Case with Community-Acquired Emphysematous Osteomyelitis Caused by RT Serotype K2 - ST25 Klebsiella pneumoniae, Japan."; RL Submitted (OCT-2019) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Site-specific tyrosine recombinase, which acts by catalyzing CC the cutting and rejoining of the recombining DNA molecules. Binds CC cooperatively to specific DNA consensus sequences that are separated CC from XerC binding sites by a short central region, forming the CC heterotetrameric XerC-XerD complex that recombines DNA substrates. The CC complex is essential to convert dimers of the bacterial chromosome into CC monomers to permit their segregation at cell division. It also CC contributes to the segregational stability of plasmids. In the complex CC XerD specifically exchanges the bottom DNA strands. {ECO:0000256|HAMAP- CC Rule:MF_01807}. CC -!- ACTIVITY REGULATION: FtsK may regulate the catalytic switch between CC XerC and XerD in the heterotetrameric complex during the two steps of CC the recombination process. {ECO:0000256|HAMAP-Rule:MF_01807}. CC -!- SUBUNIT: Forms a cyclic heterotetrameric complex composed of two CC molecules of XerC and two molecules of XerD, in which XerC interacts CC with XerD via its C-terminal region, XerD interacts with XerC via its CC C-terminal region and so on. {ECO:0000256|HAMAP-Rule:MF_01807}. CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_01807, CC ECO:0000256|SAAS:SAAS00019473}. CC -!- SIMILARITY: Belongs to the 'phage' integrase family. XerD subfamily. CC {ECO:0000256|HAMAP-Rule:MF_01807}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; CP026392; AUY20800.1; -; Genomic_DNA. DR EMBL; VTUL01000007; KAA0486132.1; -; Genomic_DNA. DR EMBL; VUBL01000034; KAA1498412.1; -; Genomic_DNA. DR EMBL; VWRA01000009; KAA5735152.1; -; Genomic_DNA. DR EMBL; VWRE01000015; KAA5741288.1; -; Genomic_DNA. DR EMBL; LEUQ01000014; KLY12001.1; -; Genomic_DNA. DR EMBL; NSMB01000014; PAX11544.1; -; Genomic_DNA. DR EMBL; PYBH01000031; PWF56157.1; -; Genomic_DNA. DR EMBL; CP041353; QEO69576.1; -; Genomic_DNA. DR EMBL; CP043932; QER49598.1; -; Genomic_DNA. DR EMBL; CP043969; QER80526.1; -; Genomic_DNA. DR EMBL; CP044039; QET11398.1; -; Genomic_DNA. DR EMBL; CP044033; QET14116.1; -; Genomic_DNA. DR EMBL; CP044047; QET21186.1; -; Genomic_DNA. DR EMBL; CP041373; QEX40677.1; -; Genomic_DNA. DR EMBL; CP042520; QFH94110.1; -; Genomic_DNA. DR EMBL; CP035194; QFU49638.1; -; Genomic_DNA. DR EMBL; CP035202; QFU58271.1; -; Genomic_DNA. DR EMBL; CP035210; QFU72742.1; -; Genomic_DNA. DR EMBL; CP026017; QFY26850.1; -; Genomic_DNA. DR EMBL; CP026023; QFY32265.1; -; Genomic_DNA. DR EMBL; CP045661; QGA01571.1; -; Genomic_DNA. DR EMBL; QOUG01001467; RCJ95709.1; -; Genomic_DNA. DR EMBL; REFB01000001; RMB23049.1; -; Genomic_DNA. DR EMBL; MPYG04000255; ROG84450.1; -; Genomic_DNA. DR EMBL; PTFF02000005; ROG94080.1; -; Genomic_DNA. DR EMBL; RDAM01000001; RRF06376.1; -; Genomic_DNA. DR EMBL; QFMH01000384; RXY83143.1; -; Genomic_DNA. DR EMBL; QFMF01000008; RXZ11009.1; -; Genomic_DNA. DR EMBL; SGOL01000007; RZG38655.1; -; Genomic_DNA. DR EMBL; FLXG01000007; SBX92074.1; -; Genomic_DNA. DR EMBL; UASO01000004; SQC22324.1; -; Genomic_DNA. DR EMBL; UAWQ01000018; SQC45359.1; -; Genomic_DNA. DR EMBL; UFBE01000027; SSF86199.1; -; Genomic_DNA. DR EMBL; UFEU01000002; SSK22593.1; -; Genomic_DNA. DR EMBL; UGKT01000001; STT06328.1; -; Genomic_DNA. DR EMBL; UGLC01000002; STT56586.1; -; Genomic_DNA. DR EMBL; UGLI01000001; STT68740.1; -; Genomic_DNA. DR EMBL; UGLH01000006; STT81935.1; -; Genomic_DNA. DR EMBL; UGLJ01000002; STT95675.1; -; Genomic_DNA. DR EMBL; UGLQ01000003; STU29063.1; -; Genomic_DNA. DR EMBL; UGMD01000002; STV03030.1; -; Genomic_DNA. DR EMBL; UGMG01000001; STV33488.1; -; Genomic_DNA. DR EMBL; UGMN01000004; STV51837.1; -; Genomic_DNA. DR EMBL; POWO01000310; TAI78213.1; -; Genomic_DNA. DR EMBL; MWQX01000029; TEA99473.1; -; Genomic_DNA. DR EMBL; STEC01000002; THS93593.1; -; Genomic_DNA. DR EMBL; VKCR01000043; TRW00494.1; -; Genomic_DNA. DR EMBL; VSSY01000003; TYL81586.1; -; Genomic_DNA. DR EMBL; SUOY02000023; TYY80925.1; -; Genomic_DNA. DR EMBL; UNZU01000004; VAP03302.1; -; Genomic_DNA. DR EMBL; UNZS01000002; VAP30480.1; -; Genomic_DNA. DR EMBL; UNZX01000003; VAP31363.1; -; Genomic_DNA. DR EMBL; UOAJ01000002; VAP98378.1; -; Genomic_DNA. DR EMBL; UOAM01000002; VAQ00471.1; -; Genomic_DNA. DR EMBL; UOAK01000002; VAQ13245.1; -; Genomic_DNA. DR EMBL; UOCG01000008; VAS63989.1; -; Genomic_DNA. DR EMBL; UWXT01000001; VCZ44708.1; -; Genomic_DNA. DR EMBL; LR134162; VEB02248.1; -; Genomic_DNA. DR EMBL; CAAGWD010000010; VGD10272.1; -; Genomic_DNA. DR EMBL; CAAGYG010000012; VGG04295.1; -; Genomic_DNA. DR EMBL; CAAHCJ010000024; VGL46693.1; -; Genomic_DNA. DR EMBL; UKJU02000001; VVK40169.1; -; Genomic_DNA. DR RefSeq; WP_004144729.1; NZ_WFJZ01000011.1. DR EnsemblBacteria; AIT00307; AIT00307; PMK1_00810. DR EnsemblBacteria; ALR26130; ALR26130; AGG09_18445. DR EnsemblBacteria; KSY13972; KSY13972; APT98_23625. DR EnsemblBacteria; SBX92074; SBX92074; SAMEA3531848_02889. DR EnsemblBacteria; SBY65672; SBY65672; SAMEA3531778_02882. DR KEGG; kpb:FH42_12590; -. DR KEGG; kpne:KU54_004475; -. DR KEGG; kpnu:LI86_04480; -. DR KEGG; kpx:PMK1_00810; -. DR PATRIC; fig|571.67.peg.4504; -. DR PATRIC; fig|573.1346.peg.1806; -. DR eggNOG; ENOG4105C13; Bacteria. DR eggNOG; COG4974; LUCA. DR KO; K04763; -. DR OrthoDB; 745068at2; -. DR Proteomes; UP000035995; Unassembled WGS sequence. DR Proteomes; UP000092856; Unassembled WGS sequence. DR Proteomes; UP000218240; Unassembled WGS sequence. DR Proteomes; UP000239813; Chromosome. DR Proteomes; UP000245017; Unassembled WGS sequence. DR Proteomes; UP000250675; Unassembled WGS sequence. DR Proteomes; UP000251721; Unassembled WGS sequence. DR Proteomes; UP000252603; Unassembled WGS sequence. DR Proteomes; UP000253217; Unassembled WGS sequence. DR Proteomes; UP000253632; Unassembled WGS sequence. DR Proteomes; UP000254103; Unassembled WGS sequence. DR Proteomes; UP000254340; Unassembled WGS sequence. DR Proteomes; UP000254387; Unassembled WGS sequence. DR Proteomes; UP000254753; Unassembled WGS sequence. DR Proteomes; UP000254799; Unassembled WGS sequence. DR Proteomes; UP000255137; Unassembled WGS sequence. DR Proteomes; UP000255192; Unassembled WGS sequence. DR Proteomes; UP000255239; Unassembled WGS sequence. DR Proteomes; UP000255518; Unassembled WGS sequence. DR Proteomes; UP000259433; Unassembled WGS sequence. DR Proteomes; UP000269373; Unassembled WGS sequence. DR Proteomes; UP000271388; Unassembled WGS sequence. DR Proteomes; UP000275975; Unassembled WGS sequence. DR Proteomes; UP000282433; Chromosome 1. DR Proteomes; UP000283322; Unassembled WGS sequence. DR Proteomes; UP000286610; Unassembled WGS sequence. DR Proteomes; UP000289252; Unassembled WGS sequence. DR Proteomes; UP000290276; Unassembled WGS sequence. DR Proteomes; UP000292131; Unassembled WGS sequence. DR Proteomes; UP000293472; Unassembled WGS sequence. DR Proteomes; UP000295084; Unassembled WGS sequence. DR Proteomes; UP000295363; Unassembled WGS sequence. DR Proteomes; UP000295429; Unassembled WGS sequence. DR Proteomes; UP000297943; Unassembled WGS sequence. DR Proteomes; UP000305572; Unassembled WGS sequence. DR Proteomes; UP000317393; Unassembled WGS sequence. DR Proteomes; UP000320855; Chromosome. DR Proteomes; UP000322263; Chromosome. DR Proteomes; UP000322675; Unassembled WGS sequence. DR Proteomes; UP000322821; Unassembled WGS sequence. DR Proteomes; UP000322831; Unassembled WGS sequence. DR Proteomes; UP000322977; Unassembled WGS sequence. DR Proteomes; UP000323019; Unassembled WGS sequence. DR Proteomes; UP000323143; Unassembled WGS sequence. DR Proteomes; UP000323986; Chromosome. DR Proteomes; UP000324100; Chromosome. DR Proteomes; UP000324565; Chromosome 1. DR Proteomes; UP000324621; Chromosome. DR Proteomes; UP000325416; Chromosome. DR Proteomes; UP000325644; Chromosome. DR Proteomes; UP000325646; Chromosome. DR Proteomes; UP000325692; Chromosome. DR Proteomes; UP000326098; Chromosome. DR Proteomes; UP000326148; Chromosome. DR Proteomes; UP000326156; Chromosome. DR Proteomes; UP000326261; Unassembled WGS sequence. DR Proteomes; UP000326442; Unassembled WGS sequence. DR Proteomes; UP000326581; Unassembled WGS sequence. DR Proteomes; UP000326754; Chromosome. DR Proteomes; UP000326989; Unassembled WGS sequence. DR Proteomes; UP000327058; Unassembled WGS sequence. DR Proteomes; UP000327175; Unassembled WGS sequence. DR Proteomes; UP000327181; Unassembled WGS sequence. DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW. DR GO; GO:0009037; F:tyrosine-based site-specific recombinase activity; IEA:UniProtKB-UniRule. DR GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW. DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW. DR GO; GO:0007059; P:chromosome segregation; IEA:UniProtKB-UniRule. DR GO; GO:0006313; P:transposition, DNA-mediated; IEA:UniProtKB-UniRule. DR Gene3D; 1.10.150.130; -; 1. DR Gene3D; 1.10.443.10; -; 1. DR HAMAP; MF_01808; Recomb_XerC_XerD; 1. DR HAMAP; MF_01807; Recomb_XerD; 1. DR InterPro; IPR011010; DNA_brk_join_enz. DR InterPro; IPR013762; Integrase-like_cat_sf. DR InterPro; IPR002104; Integrase_catalytic. DR InterPro; IPR010998; Integrase_recombinase_N. DR InterPro; IPR004107; Integrase_SAM-like_N. DR InterPro; IPR011932; Recomb_XerD. DR InterPro; IPR023009; Tyrosine_recombinase_XerC/XerD. DR Pfam; PF02899; Phage_int_SAM_1; 1. DR Pfam; PF00589; Phage_integrase; 1. DR SUPFAM; SSF56349; SSF56349; 1. DR TIGRFAMs; TIGR02225; recomb_XerD; 1. PE 3: Inferred from homology; KW Cell cycle {ECO:0000256|HAMAP-Rule:MF_01807, KW ECO:0000256|SAAS:SAAS00608023}; KW Cell division {ECO:0000256|HAMAP-Rule:MF_01807, KW ECO:0000256|SAAS:SAAS00608024}; KW Chromosome partition {ECO:0000256|HAMAP-Rule:MF_01807, KW ECO:0000256|SAAS:SAAS00608018}; KW Cytoplasm {ECO:0000256|HAMAP-Rule:MF_01807, ECO:0000256|SAAS:SAAS00094312}; KW DNA integration {ECO:0000256|HAMAP-Rule:MF_01807, KW ECO:0000256|SAAS:SAAS00298355}; KW DNA recombination {ECO:0000256|HAMAP-Rule:MF_01807, KW ECO:0000256|SAAS:SAAS01225217}; KW DNA-binding {ECO:0000256|HAMAP-Rule:MF_01807, KW ECO:0000256|SAAS:SAAS01232192}. FT DOMAIN 8..90 FT /note="Integrase_SAM-like_N" FT /evidence="ECO:0000259|Pfam:PF02899" FT DOMAIN 113..284 FT /note="Phage_integrase" FT /evidence="ECO:0000259|Pfam:PF00589" FT ACT_SITE 148 FT /evidence="ECO:0000256|HAMAP-Rule:MF_01807" FT ACT_SITE 172 FT /evidence="ECO:0000256|HAMAP-Rule:MF_01807" FT ACT_SITE 244 FT /evidence="ECO:0000256|HAMAP-Rule:MF_01807" FT ACT_SITE 247 FT /evidence="ECO:0000256|HAMAP-Rule:MF_01807" FT ACT_SITE 270 FT /evidence="ECO:0000256|HAMAP-Rule:MF_01807" FT ACT_SITE 279 FT /note="O-(3'-phospho-DNA)-tyrosine intermediate" FT /evidence="ECO:0000256|HAMAP-Rule:MF_01807" SQ SEQUENCE 298 AA; 33967 MW; DF893A2E8C2D2B88 CRC64; MKQDLALIEQ FLDALWLERN LAENTLSAYR RDLTMLVEWL HHRGLSLASV GSDDLQALLA ERQSGGYKAT STARLLSAVR RFFQHLYREK IRPDDPSALL ASPKLPQRLP KDLSEAQVER LLQAPLVEQP LELRDKAMLE VLYATGLRVS ELVGLTMSDI SLRQGVLRVV GKGNKERLVP LGEEAVLWVE NYLEYGRPWL LNGVASDVLF PSQRAQQMTR QTFWHRIKHY AVLAGIDSEK LSPHVLRHAF ATHLLNHGAD LRVVQMLLGH SDLSTTQIYT HVATERLRQL HQQHHPRA //