ID A0A060VEM3_KLEPN Unreviewed; 298 AA. AC A0A060VEM3; A0A0J2FNU8; DT 03-SEP-2014, integrated into UniProtKB/TrEMBL. DT 03-SEP-2014, sequence version 1. DT 31-JUL-2019, entry version 56. DE RecName: Full=Tyrosine recombinase XerD {ECO:0000256|HAMAP-Rule:MF_01807}; GN Name=xerD {ECO:0000256|HAMAP-Rule:MF_01807, GN ECO:0000313|EMBL:AUY20800.1}; GN Synonyms=xerD_1 {ECO:0000313|EMBL:AIT00307.1}, xerD_2 GN {ECO:0000313|EMBL:SQC22324.1}, xerD_3 {ECO:0000313|EMBL:SSW80136.1}, GN xerD_4 {ECO:0000313|EMBL:STT06328.1}; GN ORFNames=BANRA_00861 {ECO:0000313|EMBL:VCZ76978.1}, BL124_00033500 GN {ECO:0000313|EMBL:ROG84450.1}, BU230_34595 GN {ECO:0000313|EMBL:OON35129.1}, BVX91_20715 GN {ECO:0000313|EMBL:PAX11544.1}, C1459_08995 GN {ECO:0000313|EMBL:TAI78213.1}, C3483_04075 GN {ECO:0000313|EMBL:AVB70589.1}, C3F39_19500 GN {ECO:0000313|EMBL:AUY20800.1}, C4Y50_001360 GN {ECO:0000313|EMBL:ROG94080.1}, C7V41_27010 GN {ECO:0000313|EMBL:PWF56157.1}, C8P71_4754 GN {ECO:0000313|EMBL:RMB23049.1}, CK508_011550 GN {ECO:0000313|EMBL:RJS99761.1}, CSC88_13350 GN {ECO:0000313|EMBL:PPK23654.1}, DD581_26750 GN {ECO:0000313|EMBL:RXY83143.1}, DD583_10645 GN {ECO:0000313|EMBL:RXZ11009.1}, DM059_25510 GN {ECO:0000313|EMBL:RCJ95709.1}, DXF97_06455 GN {ECO:0000313|EMBL:RDT68825.1}, E0760_07990 GN {ECO:0000313|EMBL:TCZ84046.1}, E1814_19150 GN {ECO:0000313|EMBL:TDJ96518.1}, EAO17_09240 GN {ECO:0000313|EMBL:RRF06376.1}, EXT45_09365 GN {ECO:0000313|EMBL:RZG38655.1}, NCTC11679_00882 GN {ECO:0000313|EMBL:STV33488.1}, NCTC13443_06275 GN {ECO:0000313|EMBL:STT06328.1}, NCTC13465_03909 GN {ECO:0000313|EMBL:SQC45359.1}, NCTC13635_02708 GN {ECO:0000313|EMBL:VEB02248.1}, NCTC1936_04966 GN {ECO:0000313|EMBL:STT68740.1}, NCTC204_03084 GN {ECO:0000313|EMBL:STV03030.1}, NCTC5047_02873 GN {ECO:0000313|EMBL:STT81935.1}, NCTC5052_04183 GN {ECO:0000313|EMBL:STT95675.1}, NCTC5053_05258 GN {ECO:0000313|EMBL:STV51837.1}, NCTC8849_05245 GN {ECO:0000313|EMBL:STT56586.1}, NCTC9645_02901 GN {ECO:0000313|EMBL:SQC22324.1}, NCTC9661_01619 GN {ECO:0000313|EMBL:STU29063.1}, PMK1_00810 GN {ECO:0000313|EMBL:AIT00307.1}, SAMEA104305404_06336 GN {ECO:0000313|EMBL:SSW80136.1}, SAMEA104567780_02829 GN {ECO:0000313|EMBL:VGC75603.1}, SAMEA104567806_02957 GN {ECO:0000313|EMBL:VGD10272.1}, SAMEA104567818_01400 GN {ECO:0000313|EMBL:VGD71873.1}, SAMEA104567857_04294 GN {ECO:0000313|EMBL:VGG04295.1}, SAMEA23986918_01179 GN {ECO:0000313|EMBL:SSF57305.1}, SAMEA24002668_05251 GN {ECO:0000313|EMBL:SSF86199.1}, SAMEA3531848_02889 GN {ECO:0000313|EMBL:SBX92074.1}, SAMEA4364603_00912 GN {ECO:0000313|EMBL:SSK22593.1}, SAMEA4394730_02526 GN {ECO:0000313|EMBL:SVJ39266.1}, SAMEA4873587_01502 GN {ECO:0000313|EMBL:VGI55706.1}, SAMEA4873640_04643 GN {ECO:0000313|EMBL:VGL46693.1}, SK89_04359 GN {ECO:0000313|EMBL:KLY12001.1}; OS Klebsiella pneumoniae. OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales; OC Enterobacteriaceae; Klebsiella. OX NCBI_TaxID=573 {ECO:0000313|EMBL:KLY12001.1, ECO:0000313|Proteomes:UP000035995}; RN [1] {ECO:0000313|EMBL:AIT00307.1, ECO:0000313|Proteomes:UP000029666} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=PMK1 {ECO:0000313|EMBL:AIT00307.1, RC ECO:0000313|Proteomes:UP000029666}; RX PubMed=25267672; RA Stoesser N., Giess A., Batty E.M., Sheppard A.E., Walker A.S., RA Wilson D.J., Didelot X., Bashir A., Sebra R., Kasarskis A., RA Sthapit B., Shakya M., Kelly D., Pollard A.J., Peto T.E., Crook D.W., RA Donnelly P., Thorson S., Amatya P., Joshi S.; RT "Genome Sequencing of an Extended Series of NDM-Producing Klebsiella RT pneumoniae Isolates from Neonatal Infections in a Nepali Hospital RT Characterizes the Extent of Community- versus Hospital-Associated RT Transmission in an Endemic Setting."; RL Antimicrob. Agents Chemother. 58:7347-7357(2014). RN [2] {ECO:0000313|EMBL:KLY12001.1, ECO:0000313|Proteomes:UP000035995} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=CHS153 {ECO:0000313|EMBL:KLY12001.1, RC ECO:0000313|Proteomes:UP000035995}; RG The Broad Institute Genomics Platform; RG The Broad Institute Genome Sequencing Center for Infectious Disease; RA Earl A.M., Onderdonk A.B., Kirby J., Ferraro M.J., Huang S., RA Spencer M., Fodor A., Hooper D., Dekker J., O'Brien T., Quan V., RA Gombosev A., Delaney M., DuBois A., Ernst C., Kim D.S., Rossman W., RA Gohs F., Petruso H., Nozar T., Mougeot F., Manson-McGuire A., RA Young S., Abouelleil A., Cao P., Chapman S.B., Griggs A., Priest M., RA Shea T., Wortman I., Wortman J.R., Nusbaum C., Birren B.; RT "The Genome Sequence of None."; RL Submitted (JUN-2015) to the EMBL/GenBank/DDBJ databases. RN [3] {ECO:0000313|EMBL:OON35129.1, ECO:0000313|Proteomes:UP000190740} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=MB369 {ECO:0000313|EMBL:OON35129.1, RC ECO:0000313|Proteomes:UP000190740}; RA Mah S.A., Swanson W.J., Moy G.W., Vacquier V.D.; RL Submitted (JAN-2017) to the EMBL/GenBank/DDBJ databases. RN [4] {ECO:0000313|EMBL:PAX11544.1, ECO:0000313|Proteomes:UP000218240} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=WBB417 {ECO:0000313|EMBL:PAX11544.1, RC ECO:0000313|Proteomes:UP000218240}; RA Koh T.H., Abdul Rahman N., Teo J.W., La M.-V., Periaswamy B., RA Chen S.L.; RT "Draft Genome Sequence of a Singapore Klebsiella pneumoniae subsp. RT pnuemoniae isolate DS32358_14 Encoding the Carbapenemase Gene blaVIM- RT 1."; RL Submitted (SEP-2017) to the EMBL/GenBank/DDBJ databases. RN [5] {ECO:0000313|EMBL:RRF06376.1, ECO:0000313|Proteomes:UP000275975} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=KLPN_104 {ECO:0000313|EMBL:RRF06376.1, RC ECO:0000313|Proteomes:UP000275975}; RX PubMed=30373801; RA Tamma P.D., Fan Y., Bergman Y., Pertea G., Kazmi A., Lewis S., RA Carroll K.C., Schatz M.C., Timp W., Simner P.J.; RT "Applying Rapid Whole Genome Sequencing to Predict Phenotypic RT Antimicrobial Susceptibility Testing Results Among Carbapenem- RT Resistant Klebsiella pneumoniae Clinical Isolates."; RL Antimicrob. Agents Chemother. 0:0-0(2018). RN [6] {ECO:0000313|EMBL:PPK23654.1, ECO:0000313|Proteomes:UP000238271} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=PN030E4 {ECO:0000313|EMBL:PPK23654.1, RC ECO:0000313|Proteomes:UP000238271}; RX PubMed=29479347; DOI=10.3389/fmicb.2018.00188; RA Founou L.L., Founou R.C., Allam M., Ismail A., Djoko C.F., RA Essack S.Y.; RT "Genome Sequencing of Extended-Spectrum ?-Lactamase (ESBL)-Producing RT Klebsiella pneumoniae Isolated from Pigs and Abattoir Workers in RT Cameroon."; RL Front. Microbiol. 9:188-188(2018). RN [7] {ECO:0000313|Proteomes:UP000239813} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=KPNIH48 {ECO:0000313|Proteomes:UP000239813}; RX PubMed=29437920; RG NISC Comparative Sequencing Program; RA Weingarten R.A., Johnson R.C., Conlan S., Ramsburg A.M., Dekker J.P., RA Lau A.F., Khil P., Odom R.T., Deming C., Park M., Thomas P.J., RA Henderson D.K., Palmore T.N., Segre J.A., Frank K.M.; RT "Genomic Analysis of Hospital Plumbing Reveals Diverse Reservoir of RT Bacterial Plasmids Conferring Carbapenem Resistance."; RL MBio 9:e02011-17(2018). RN [8] {ECO:0000313|EMBL:AUY20800.1} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=KPNIH48 {ECO:0000313|EMBL:AUY20800.1}; RA Weingarten R.A., Johnson R.C., Conlan S., Ramsburg A.M., Dekker J.P., RA Lau A.F., Khil P., Odom R.T., Deming C., Park M., Thomas P.J., RA Henderson D.K., Palmore T.N., Segre J.A., Frank K.M.; RT "Genomic Analysis of Hospital Plumbing Reveals Diverse Reservoir of RT Bacterial Plasmids Conferring Carbapenem Resistance."; RL MBio 0:0-0(2018). RN [9] {ECO:0000313|EMBL:TAI78213.1, ECO:0000313|Proteomes:UP000292131} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=G702R2B5 {ECO:0000313|EMBL:TAI78213.1, RC ECO:0000313|Proteomes:UP000292131}; RA Allam M.; RT "Whole Genome Sequencing of Extended Spectrum-Beta-lactamases RT producing Klebsiella pneumoniae: Clonal spread of lineage ST 152."; RL Submitted (JAN-2018) to the EMBL/GenBank/DDBJ databases. RN [10] {ECO:0000313|EMBL:AVB70589.1, ECO:0000313|Proteomes:UP000238332} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=NUHL30457 {ECO:0000313|EMBL:AVB70589.1, RC ECO:0000313|Proteomes:UP000238332}; RA Liu Y.; RT "Genome of Klebsiella pneumoniae NUHL3069."; RL Submitted (FEB-2018) to the EMBL/GenBank/DDBJ databases. RN [11] {ECO:0000313|EMBL:PWF56157.1, ECO:0000313|Proteomes:UP000245017} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=KPL0.2 {ECO:0000313|EMBL:PWF56157.1, RC ECO:0000313|Proteomes:UP000245017}; RA Le Guern R., Grandjean T., Bauduin M., Loquet A., Faure K., Kipnis E., RA Dessein R.; RT "A murine model of gut colonization with Klebsiella pneumoniae NDM."; RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases. RN [12] {ECO:0000313|EMBL:RXY83143.1, ECO:0000313|Proteomes:UP000289252, ECO:0000313|Proteomes:UP000290276} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=3DZ2-3B {ECO:0000313|EMBL:RXY83143.1, RC ECO:0000313|Proteomes:UP000290276}, and 775-DZ2-4B RC {ECO:0000313|EMBL:RXZ11009.1, ECO:0000313|Proteomes:UP000289252}; RA Zhang R., Li J., Wang Y., Shen J., Shen Z., Wang S.; RT "The molecular epidemiology of the NDM positive non-E. coli RT Enterobacteriaceae in poultry production environment."; RL Submitted (MAY-2018) to the EMBL/GenBank/DDBJ databases. RN [13] {ECO:0000313|Proteomes:UP000250675, ECO:0000313|Proteomes:UP000251721, ECO:0000313|Proteomes:UP000254103} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=NCTC11679 {ECO:0000313|EMBL:STV33488.1, RC ECO:0000313|Proteomes:UP000255239}, NCTC13443 RC {ECO:0000313|EMBL:STT06328.1, ECO:0000313|Proteomes:UP000255518}, RC NCTC13465 {ECO:0000313|EMBL:SQC45359.1, RC ECO:0000313|Proteomes:UP000251721}, NCTC1936 RC {ECO:0000313|EMBL:STT68740.1, ECO:0000313|Proteomes:UP000254753}, RC NCTC204 {ECO:0000313|EMBL:STV03030.1, RC ECO:0000313|Proteomes:UP000255192}, NCTC5047 RC {ECO:0000313|EMBL:STT81935.1, ECO:0000313|Proteomes:UP000254340}, RC NCTC5052 {ECO:0000313|EMBL:STT95675.1, RC ECO:0000313|Proteomes:UP000254103}, NCTC5053 RC {ECO:0000313|EMBL:STV51837.1, ECO:0000313|Proteomes:UP000254387}, RC NCTC8849 {ECO:0000313|EMBL:STT56586.1, RC ECO:0000313|Proteomes:UP000254799}, NCTC9645 RC {ECO:0000313|EMBL:SQC22324.1, ECO:0000313|Proteomes:UP000250675}, and RC NCTC9661 {ECO:0000313|EMBL:STU29063.1, RC ECO:0000313|Proteomes:UP000255137}; RG Pathogen Informatics; RA Doyle S.; RL Submitted (JUN-2018) to the EMBL/GenBank/DDBJ databases. RN [14] {ECO:0000313|EMBL:RCJ95709.1, ECO:0000313|Proteomes:UP000253217} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=BC_4223 {ECO:0000313|EMBL:RCJ95709.1, RC ECO:0000313|Proteomes:UP000253217}; RA Martins R.C.R., Perdigao-Neto L.V., Costa S.F., Levin A.S.S.; RT "Klebsiella pneumoniae genome sequencing and assembly."; RL Submitted (JUL-2018) to the EMBL/GenBank/DDBJ databases. RN [15] {ECO:0000313|EMBL:RDT68825.1, ECO:0000313|Proteomes:UP000255489} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=1-RC-17-04409-2 {ECO:0000313|EMBL:RDT68825.1, RC ECO:0000313|Proteomes:UP000255489}; RA Doi Y.; RT "The use of a cohorting ward and systematic surveillance cultures for RT the control of a Klebsiella pneumoniae carbapenemase (KPC)-producing RT Enterobacteriaceae outbreak."; RL Submitted (JUL-2018) to the EMBL/GenBank/DDBJ databases. RN [16] {ECO:0000313|EMBL:RCJ95709.1, ECO:0000313|Proteomes:UP000253217} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=BC_4223 {ECO:0000313|EMBL:RCJ95709.1, RC ECO:0000313|Proteomes:UP000253217}; RA Quirk P.G., Krulwich T.A.; RL Submitted (JUL-2018) to the EMBL/GenBank/DDBJ databases. RN [17] {ECO:0000313|EMBL:RJS99761.1, ECO:0000313|Proteomes:UP000218552} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=B35 {ECO:0000313|EMBL:RJS99761.1, RC ECO:0000313|Proteomes:UP000218552}; RA Araujo B.F., Campos P.A., Royer S., Ferreira M.L., Goncalves I.R., RA Batistao D.W.F., Cerdeira L.T., Brito C.S., Gontijo-Filho P., RA Ribas R.M.; RT "Klebsiella pneumoniae KPC-2-producing B35 strain."; RL Submitted (SEP-2018) to the EMBL/GenBank/DDBJ databases. RN [18] {ECO:0000313|EMBL:RMB23049.1, ECO:0000313|Proteomes:UP000271388} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=JE01 {ECO:0000313|EMBL:RMB23049.1, RC ECO:0000313|Proteomes:UP000271388}; RA Guss A.; RT "PacBio sequencing to determine microbial DNA methylation."; RL Submitted (OCT-2018) to the EMBL/GenBank/DDBJ databases. RN [19] {ECO:0000313|EMBL:VCZ76978.1, ECO:0000313|Proteomes:UP000276286} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Kpneu043 {ECO:0000313|EMBL:VCZ76978.1}; RA Noll B N.; RL Submitted (OCT-2018) to the EMBL/GenBank/DDBJ databases. RN [20] {ECO:0000313|EMBL:ROG94080.1, ECO:0000313|Proteomes:UP000286610} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=CRK0390 {ECO:0000313|EMBL:ROG94080.1, RC ECO:0000313|Proteomes:UP000286610}; RA Vanduin D., Fouts D., Sutton G., Nguyen K., Hujer A., Hujer K., RA Bonomo R.; RL Submitted (OCT-2018) to the EMBL/GenBank/DDBJ databases. RN [21] {ECO:0000313|EMBL:ROG84450.1, ECO:0000313|Proteomes:UP000283322} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=CRK0165 {ECO:0000313|EMBL:ROG84450.1, RC ECO:0000313|Proteomes:UP000283322}; RA Vanduin D., Fouts D., Wright M., Sutton G., Nguyen K., Kreiswirth B., RA Chen L., Rojas L., Hujer A., Hujer K., Bonomo R., Adams M.; RL Submitted (OCT-2018) to the EMBL/GenBank/DDBJ databases. RN [22] {ECO:0000313|EMBL:RZG38655.1, ECO:0000313|Proteomes:UP000293472} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=53 {ECO:0000313|EMBL:RZG38655.1, RC ECO:0000313|Proteomes:UP000293472}; RA Newire E., Aydin A., Juma S., Enne V., Roberts A.P.; RT "Identification of a Type IV CRISPR-Cas system located exclusively on RT IncHI1B/ IncFIB plasmids in Enterobacteriaceae."; RL Submitted (FEB-2019) to the EMBL/GenBank/DDBJ databases. RN [23] {ECO:0000313|EMBL:TDJ96518.1, ECO:0000313|Proteomes:UP000294951} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=RJ1071 {ECO:0000313|EMBL:TDJ96518.1, RC ECO:0000313|Proteomes:UP000294951}; RA Wang S.; RT "Multidrug-Resistant Klebsiella pneumoniae Clinical Bloodstream RT Isolates in Shanghai, China."; RL Submitted (MAR-2019) to the EMBL/GenBank/DDBJ databases. RN [24] {ECO:0000313|EMBL:TCZ84046.1, ECO:0000313|Proteomes:UP000294891} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Y17 tetA {ECO:0000313|EMBL:TCZ84046.1, RC ECO:0000313|Proteomes:UP000294891}; RA Sun Q., Wang Y., Dong N., Shen L., Zhou H., Hu Y., Gu D., Chen S., RA Zhang R., Ji Q.; RT "The application of CRISPR/Cas9-based genome editing in studying the RT mechanism of pandrug resistance in Klebsiella pneumoniae."; RL Submitted (MAR-2019) to the EMBL/GenBank/DDBJ databases. RN [25] {ECO:0000313|Proteomes:UP000294936, ECO:0000313|Proteomes:UP000295037, ECO:0000313|Proteomes:UP000295084} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=4300STDY6470422 {ECO:0000313|EMBL:SSK22593.1, RC ECO:0000313|Proteomes:UP000252603}, 4300STDY6542360 RC {ECO:0000313|EMBL:SVJ39266.1, ECO:0000313|Proteomes:UP000258067}, RC 4300STDY6636938 {ECO:0000313|EMBL:SSF57305.1, RC ECO:0000313|Proteomes:UP000262540}, 4300STDY6636959 RC {ECO:0000313|EMBL:SSF86199.1, ECO:0000313|Proteomes:UP000253632}, RC 4300STDY7045912 {ECO:0000313|EMBL:SSW80136.1}, 5012STDY7312565 RC {ECO:0000313|EMBL:VGC75603.1, ECO:0000313|Proteomes:UP000295619}, RC 5012STDY7312591 {ECO:0000313|EMBL:VGD10272.1, RC ECO:0000313|Proteomes:UP000295363}, 5012STDY7312603 RC {ECO:0000313|EMBL:VGD71873.1, ECO:0000313|Proteomes:UP000295037}, RC 5012STDY7312675 {ECO:0000313|EMBL:VGG04295.1, RC ECO:0000313|Proteomes:UP000295429}, 5012STDY7626386 RC {ECO:0000313|EMBL:VGI55706.1, ECO:0000313|Proteomes:UP000294936}, RC 5012STDY7626438 {ECO:0000313|EMBL:VGL46693.1, RC ECO:0000313|Proteomes:UP000295084}, NCTC13635 RC {ECO:0000313|EMBL:VEB02248.1, ECO:0000313|Proteomes:UP000282433}, and RC PB463 {ECO:0000313|EMBL:SBX92074.1, RC ECO:0000313|Proteomes:UP000092856}; RG Pathogen Informatics; RL Submitted (MAR-2019) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Site-specific tyrosine recombinase, which acts by CC catalyzing the cutting and rejoining of the recombining DNA CC molecules. Binds cooperatively to specific DNA consensus sequences CC that are separated from XerC binding sites by a short central CC region, forming the heterotetrameric XerC-XerD complex that CC recombines DNA substrates. The complex is essential to convert CC dimers of the bacterial chromosome into monomers to permit their CC segregation at cell division. It also contributes to the CC segregational stability of plasmids. In the complex XerD CC specifically exchanges the bottom DNA strands. {ECO:0000256|HAMAP- CC Rule:MF_01807}. CC -!- ACTIVITY REGULATION: FtsK may regulate the catalytic switch CC between XerC and XerD in the heterotetrameric complex during the CC two steps of the recombination process. {ECO:0000256|HAMAP- CC Rule:MF_01807}. CC -!- SUBUNIT: Forms a cyclic heterotetrameric complex composed of two CC molecules of XerC and two molecules of XerD, in which XerC CC interacts with XerD via its C-terminal region, XerD interacts with CC XerC via its C-terminal region and so on. {ECO:0000256|HAMAP- CC Rule:MF_01807}. CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_01807, CC ECO:0000256|SAAS:SAAS00019473}. CC -!- SIMILARITY: Belongs to the 'phage' integrase family. XerD CC subfamily. {ECO:0000256|HAMAP-Rule:MF_01807}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; CP008929; AIT00307.1; -; Genomic_DNA. DR EMBL; CP026392; AUY20800.1; -; Genomic_DNA. DR EMBL; CP026586; AVB70589.1; -; Genomic_DNA. DR EMBL; LEUQ01000014; KLY12001.1; -; Genomic_DNA. DR EMBL; MTSV01001318; OON35129.1; -; Genomic_DNA. DR EMBL; NSMB01000014; PAX11544.1; -; Genomic_DNA. DR EMBL; PDVM01000039; PPK23654.1; -; Genomic_DNA. DR EMBL; PYBH01000031; PWF56157.1; -; Genomic_DNA. DR EMBL; QOUG01001467; RCJ95709.1; -; Genomic_DNA. DR EMBL; QRBO01000008; RDT68825.1; -; Genomic_DNA. DR EMBL; NTHY02000039; RJS99761.1; -; Genomic_DNA. DR EMBL; REFB01000001; RMB23049.1; -; Genomic_DNA. DR EMBL; MPYG04000255; ROG84450.1; -; Genomic_DNA. DR EMBL; PTFF02000005; ROG94080.1; -; Genomic_DNA. DR EMBL; RDAM01000001; RRF06376.1; -; Genomic_DNA. DR EMBL; QFMH01000384; RXY83143.1; -; Genomic_DNA. DR EMBL; QFMF01000008; RXZ11009.1; -; Genomic_DNA. DR EMBL; SGOL01000007; RZG38655.1; -; Genomic_DNA. DR EMBL; FLXG01000007; SBX92074.1; -; Genomic_DNA. DR EMBL; UASO01000004; SQC22324.1; -; Genomic_DNA. DR EMBL; UAWQ01000018; SQC45359.1; -; Genomic_DNA. DR EMBL; UFBK01000003; SSF57305.1; -; Genomic_DNA. DR EMBL; UFBE01000027; SSF86199.1; -; Genomic_DNA. DR EMBL; UFEU01000002; SSK22593.1; -; Genomic_DNA. DR EMBL; UFQE01000154; SSW80136.1; -; Genomic_DNA. DR EMBL; UGKT01000001; STT06328.1; -; Genomic_DNA. DR EMBL; UGLC01000002; STT56586.1; -; Genomic_DNA. DR EMBL; UGLI01000001; STT68740.1; -; Genomic_DNA. DR EMBL; UGLH01000006; STT81935.1; -; Genomic_DNA. DR EMBL; UGLJ01000002; STT95675.1; -; Genomic_DNA. DR EMBL; UGLQ01000003; STU29063.1; -; Genomic_DNA. DR EMBL; UGMD01000002; STV03030.1; -; Genomic_DNA. DR EMBL; UGMG01000001; STV33488.1; -; Genomic_DNA. DR EMBL; UGMN01000004; STV51837.1; -; Genomic_DNA. DR EMBL; UIRA01000004; SVJ39266.1; -; Genomic_DNA. DR EMBL; POWO01000310; TAI78213.1; -; Genomic_DNA. DR EMBL; SKFD01000008; TCZ84046.1; -; Genomic_DNA. DR EMBL; SMTN01000021; TDJ96518.1; -; Genomic_DNA. DR EMBL; UWYB01000001; VCZ76978.1; -; Genomic_DNA. DR EMBL; LR134162; VEB02248.1; -; Genomic_DNA. DR EMBL; CAAGVV010000005; VGC75603.1; -; Genomic_DNA. DR EMBL; CAAGWD010000010; VGD10272.1; -; Genomic_DNA. DR EMBL; CAAGWQ010000003; VGD71873.1; -; Genomic_DNA. DR EMBL; CAAGYG010000012; VGG04295.1; -; Genomic_DNA. DR EMBL; CAAHAK010000002; VGI55706.1; -; Genomic_DNA. DR EMBL; CAAHCJ010000024; VGL46693.1; -; Genomic_DNA. DR RefSeq; WP_004144729.1; NZ_UWZM01000001.1. DR EnsemblBacteria; AIT00307; AIT00307; PMK1_00810. DR EnsemblBacteria; ALR26130; ALR26130; AGG09_18445. DR EnsemblBacteria; KLY12001; KLY12001; SK89_04359. DR EnsemblBacteria; KSY13972; KSY13972; APT98_23625. DR EnsemblBacteria; SBX92074; SBX92074; SAMEA3531848_02889. DR EnsemblBacteria; SBY65672; SBY65672; SAMEA3531778_02882. DR KEGG; kpb:FH42_12590; -. DR KEGG; kpne:KU54_004475; -. DR KEGG; kpnu:LI86_04480; -. DR KEGG; kpx:PMK1_00810; -. DR PATRIC; fig|571.67.peg.4504; -. DR PATRIC; fig|573.1346.peg.1806; -. DR eggNOG; ENOG4105C13; Bacteria. DR eggNOG; COG4974; LUCA. DR KO; K04763; -. DR OrthoDB; 745068at2; -. DR Proteomes; UP000029666; Chromosome. DR Proteomes; UP000035995; Unassembled WGS sequence. DR Proteomes; UP000092856; Unassembled WGS sequence. DR Proteomes; UP000190740; Unassembled WGS sequence. DR Proteomes; UP000218240; Unassembled WGS sequence. DR Proteomes; UP000218552; Unassembled WGS sequence. DR Proteomes; UP000238271; Unassembled WGS sequence. DR Proteomes; UP000238332; Chromosome. DR Proteomes; UP000239813; Chromosome. DR Proteomes; UP000245017; Unassembled WGS sequence. DR Proteomes; UP000250675; Unassembled WGS sequence. DR Proteomes; UP000251721; Unassembled WGS sequence. DR Proteomes; UP000252603; Unassembled WGS sequence. DR Proteomes; UP000253217; Unassembled WGS sequence. DR Proteomes; UP000253632; Unassembled WGS sequence. DR Proteomes; UP000254103; Unassembled WGS sequence. DR Proteomes; UP000254340; Unassembled WGS sequence. DR Proteomes; UP000254387; Unassembled WGS sequence. DR Proteomes; UP000254753; Unassembled WGS sequence. DR Proteomes; UP000254799; Unassembled WGS sequence. DR Proteomes; UP000255137; Unassembled WGS sequence. DR Proteomes; UP000255192; Unassembled WGS sequence. DR Proteomes; UP000255239; Unassembled WGS sequence. DR Proteomes; UP000255489; Unassembled WGS sequence. DR Proteomes; UP000255518; Unassembled WGS sequence. DR Proteomes; UP000258067; Unassembled WGS sequence. DR Proteomes; UP000262540; Unassembled WGS sequence. DR Proteomes; UP000271388; Unassembled WGS sequence. DR Proteomes; UP000275975; Unassembled WGS sequence. DR Proteomes; UP000276286; Unassembled WGS sequence. DR Proteomes; UP000282433; Chromosome 1. DR Proteomes; UP000283322; Unassembled WGS sequence. DR Proteomes; UP000286610; Unassembled WGS sequence. DR Proteomes; UP000289252; Unassembled WGS sequence. DR Proteomes; UP000290276; Unassembled WGS sequence. DR Proteomes; UP000292131; Unassembled WGS sequence. DR Proteomes; UP000293472; Unassembled WGS sequence. DR Proteomes; UP000294891; Unassembled WGS sequence. DR Proteomes; UP000294936; Unassembled WGS sequence. DR Proteomes; UP000294951; Unassembled WGS sequence. DR Proteomes; UP000295037; Unassembled WGS sequence. DR Proteomes; UP000295084; Unassembled WGS sequence. DR Proteomes; UP000295363; Unassembled WGS sequence. DR Proteomes; UP000295429; Unassembled WGS sequence. DR Proteomes; UP000295619; Unassembled WGS sequence. DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW. DR GO; GO:0009037; F:tyrosine-based site-specific recombinase activity; IEA:UniProtKB-UniRule. DR GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW. DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW. DR GO; GO:0007059; P:chromosome segregation; IEA:UniProtKB-UniRule. DR GO; GO:0006313; P:transposition, DNA-mediated; IEA:UniProtKB-UniRule. DR Gene3D; 1.10.150.130; -; 1. DR Gene3D; 1.10.443.10; -; 1. DR HAMAP; MF_01808; Recomb_XerC_XerD; 1. DR HAMAP; MF_01807; Recomb_XerD; 1. DR InterPro; IPR011010; DNA_brk_join_enz. DR InterPro; IPR013762; Integrase-like_cat_sf. DR InterPro; IPR002104; Integrase_catalytic. DR InterPro; IPR010998; Integrase_recombinase_N. DR InterPro; IPR004107; Integrase_SAM-like_N. DR InterPro; IPR011932; Recomb_XerD. DR InterPro; IPR023009; Tyrosine_recombinase_XerC/XerD. DR Pfam; PF02899; Phage_int_SAM_1; 1. DR Pfam; PF00589; Phage_integrase; 1. DR SUPFAM; SSF56349; SSF56349; 1. DR TIGRFAMs; TIGR02225; recomb_XerD; 1. PE 3: Inferred from homology; KW Cell cycle {ECO:0000256|HAMAP-Rule:MF_01807, KW ECO:0000256|SAAS:SAAS00608023}; KW Cell division {ECO:0000256|HAMAP-Rule:MF_01807, KW ECO:0000256|SAAS:SAAS00608024}; KW Chromosome partition {ECO:0000256|HAMAP-Rule:MF_01807, KW ECO:0000256|SAAS:SAAS00608018}; KW Complete proteome {ECO:0000313|Proteomes:UP000029666, KW ECO:0000313|Proteomes:UP000035995, ECO:0000313|Proteomes:UP000092856, KW ECO:0000313|Proteomes:UP000190740}; KW Cytoplasm {ECO:0000256|HAMAP-Rule:MF_01807, KW ECO:0000256|SAAS:SAAS00094312}; KW DNA integration {ECO:0000256|HAMAP-Rule:MF_01807, KW ECO:0000256|SAAS:SAAS00298355}; KW DNA recombination {ECO:0000256|HAMAP-Rule:MF_01807, KW ECO:0000256|SAAS:SAAS00019433}; KW DNA-binding {ECO:0000256|HAMAP-Rule:MF_01807, KW ECO:0000256|SAAS:SAAS00424103}. FT DOMAIN 8 90 Integrase_SAM-like_N. {ECO:0000259|Pfam: FT PF02899}. FT DOMAIN 113 284 Phage_integrase. {ECO:0000259|Pfam: FT PF00589}. FT ACT_SITE 148 148 {ECO:0000256|HAMAP-Rule:MF_01807}. FT ACT_SITE 172 172 {ECO:0000256|HAMAP-Rule:MF_01807}. FT ACT_SITE 244 244 {ECO:0000256|HAMAP-Rule:MF_01807}. FT ACT_SITE 247 247 {ECO:0000256|HAMAP-Rule:MF_01807}. FT ACT_SITE 270 270 {ECO:0000256|HAMAP-Rule:MF_01807}. FT ACT_SITE 279 279 O-(3'-phospho-DNA)-tyrosine intermediate. FT {ECO:0000256|HAMAP-Rule:MF_01807}. SQ SEQUENCE 298 AA; 33967 MW; DF893A2E8C2D2B88 CRC64; MKQDLALIEQ FLDALWLERN LAENTLSAYR RDLTMLVEWL HHRGLSLASV GSDDLQALLA ERQSGGYKAT STARLLSAVR RFFQHLYREK IRPDDPSALL ASPKLPQRLP KDLSEAQVER LLQAPLVEQP LELRDKAMLE VLYATGLRVS ELVGLTMSDI SLRQGVLRVV GKGNKERLVP LGEEAVLWVE NYLEYGRPWL LNGVASDVLF PSQRAQQMTR QTFWHRIKHY AVLAGIDSEK LSPHVLRHAF ATHLLNHGAD LRVVQMLLGH SDLSTTQIYT HVATERLRQL HQQHHPRA //