ID A0A060VEM3_KLEPN Unreviewed; 298 AA. AC A0A060VEM3; DT 03-SEP-2014, integrated into UniProtKB/TrEMBL. DT 03-SEP-2014, sequence version 1. DT 18-JUL-2018, entry version 45. DE RecName: Full=Tyrosine recombinase XerD {ECO:0000256|HAMAP-Rule:MF_01807}; GN Name=xerD {ECO:0000256|HAMAP-Rule:MF_01807, GN ECO:0000313|EMBL:CDQ52864.1}; GN Synonyms=xerD_1 {ECO:0000313|EMBL:AIT00307.1}; GN ORFNames=AGG09_18445 {ECO:0000313|EMBL:ALR26130.1}, AM459_23035 GN {ECO:0000313|EMBL:AVO79824.1}, B1727_10085 GN {ECO:0000313|EMBL:OXT23834.1}, BB785_04440 GN {ECO:0000313|EMBL:APP57120.1}, BL124_0033285 GN {ECO:0000313|EMBL:OSU05398.1}, BU230_34595 GN {ECO:0000313|EMBL:OON35129.1}, BVX91_20715 GN {ECO:0000313|EMBL:PAX11544.1}, C3483_04075 GN {ECO:0000313|EMBL:AVB70589.1}, C3F39_19500 GN {ECO:0000313|EMBL:AUY20800.1}, C9J88_05130 GN {ECO:0000313|EMBL:AVS25444.1}, CPT10_00170 GN {ECO:0000313|EMBL:PCL83612.1}, CSC88_13350 GN {ECO:0000313|EMBL:PPK23654.1}, CWQ24_04570 GN {ECO:0000313|EMBL:AUA49519.1}, KpST82_3931 GN {ECO:0000313|EMBL:CDQ52864.1}, PMK1_00810 GN {ECO:0000313|EMBL:AIT00307.1}, SAMEA3531848_02889 GN {ECO:0000313|EMBL:SBX92074.1}, SM57_03567 GN {ECO:0000313|EMBL:KMW85539.1}; OS Klebsiella pneumoniae. OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales; OC Enterobacteriaceae; Klebsiella. OX NCBI_TaxID=573 {ECO:0000313|EMBL:CDQ52864.1, ECO:0000313|Proteomes:UP000053587}; RN [1] {ECO:0000313|EMBL:AIT00307.1, ECO:0000313|Proteomes:UP000029666} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=PMK1 {ECO:0000313|EMBL:AIT00307.1, RC ECO:0000313|Proteomes:UP000029666}; RX PubMed=25267672; RA Stoesser N., Giess A., Batty E.M., Sheppard A.E., Walker A.S., RA Wilson D.J., Didelot X., Bashir A., Sebra R., Kasarskis A., RA Sthapit B., Shakya M., Kelly D., Pollard A.J., Peto T.E., Crook D.W., RA Donnelly P., Thorson S., Amatya P., Joshi S.; RT "Genome Sequencing of an Extended Series of NDM-Producing Klebsiella RT pneumoniae Isolates from Neonatal Infections in a Nepali Hospital RT Characterizes the Extent of Community- versus Hospital-Associated RT Transmission in an Endemic Setting."; RL Antimicrob. Agents Chemother. 58:7347-7357(2014). RN [2] {ECO:0000313|EMBL:CDQ52864.1, ECO:0000313|Proteomes:UP000053587} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=SB3193 {ECO:0000313|EMBL:CDQ52864.1, RC ECO:0000313|Proteomes:UP000053587}; RA Genoscope - CEA; RL Submitted (MAY-2014) to the EMBL/GenBank/DDBJ databases. RN [3] {ECO:0000313|EMBL:KMW85539.1, ECO:0000313|Proteomes:UP000037134} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=MGH83 {ECO:0000313|EMBL:KMW85539.1, RC ECO:0000313|Proteomes:UP000037134}; RG The Broad Institute Genomics Platform; RG The Broad Institute Genome Sequencing Center for Infectious Disease; RA Earl A.M., Onderdonk A.B., Kirby J., Ferraro M.J., Huang S., RA Spencer M., Fodor A., Hooper D., Dekker J., O'Brien T., Quan V., RA Gombosev A., Delaney M., Dubois A., Ernst C., Kim D.S., Rossman W., RA Gohs F., Petruso H., Nozar T., Mougeot F., Manson-Mcguire A., RA Young S., Abouelleil A., Cao P., Chapman S.B., Griggs A., Priest M., RA Shea T., Wortman I., Wortman J.R., Nusbaum C., Birren B.; RT "The Genome Sequence of None."; RL Submitted (JUN-2015) to the EMBL/GenBank/DDBJ databases. RN [4] {ECO:0000313|Proteomes:UP000067608} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=CAV1193 {ECO:0000313|Proteomes:UP000067608}; RA Sheppard A.E., Stoesser N., Sebra R., Kasarskis A., Deikus G., RA Anson L., Walker A.S., Peto T.E., Crook D.W., Mathers A.J.; RT "Complete Genome Sequence of the KPC-producing Klebsiella pneumoniae RT strain CAV1193."; RL Submitted (NOV-2015) to the EMBL/GenBank/DDBJ databases. RN [5] {ECO:0000313|EMBL:ALR26130.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=CAV1193 {ECO:0000313|EMBL:ALR26130.1}; RX PubMed=26823590; RA Sheppard A.E., Stoesser N., Sebra R., Kasarskis A., Deikus G., RA Anson L., Walker A.S., Peto T.E., Crook D.W., Mathers A.J.; RT "Complete Genome Sequence of KPC-Producing Klebsiella pneumoniae RT Strain CAV1193."; RL Genome Announc. 4:e01649-15(2016). RN [6] {ECO:0000313|EMBL:SBX92074.1, ECO:0000313|Proteomes:UP000092856} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=PB463 {ECO:0000313|EMBL:SBX92074.1, RC ECO:0000313|Proteomes:UP000092856}; RG Pathogen Informatics; RL Submitted (JUL-2016) to the EMBL/GenBank/DDBJ databases. RN [7] {ECO:0000313|EMBL:APP57120.1, ECO:0000313|Proteomes:UP000184736} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Kp_Goe_827026 {ECO:0000313|EMBL:APP57120.1, RC ECO:0000313|Proteomes:UP000184736}; RA Bohne W., Bunk B., Overmann J., Gross U., Zautner A.E.; RT "A nosocomial outbreak of oxa48-expressing Klebsialla pneumoniae in RT Lower Saxony."; RL Submitted (DEC-2016) to the EMBL/GenBank/DDBJ databases. RN [8] {ECO:0000313|EMBL:OON35129.1, ECO:0000313|Proteomes:UP000190740} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=MB369 {ECO:0000313|EMBL:OON35129.1, RC ECO:0000313|Proteomes:UP000190740}; RA Mah S.A., Swanson W.J., Moy G.W., Vacquier V.D.; RL Submitted (JAN-2017) to the EMBL/GenBank/DDBJ databases. RN [9] {ECO:0000313|EMBL:OXT23834.1, ECO:0000313|Proteomes:UP000215037} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=OK8 {ECO:0000313|EMBL:OXT23834.1, RC ECO:0000313|Proteomes:UP000215037}; RA Nagamalleswari E., Nagaraja V.; RT "Draft genome analysis of Klebsiella pneumoniae OK8."; RL Submitted (MAR-2017) to the EMBL/GenBank/DDBJ databases. RN [10] {ECO:0000313|EMBL:OSU05398.1, ECO:0000313|Proteomes:UP000186691} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=1163_2046 {ECO:0000313|EMBL:OSU05398.1, RC ECO:0000313|Proteomes:UP000186691}; RA Afonso C.L., Miller P.J., Scott M.A., Spackman E., Goraichik I., RA Dimitrov K.M., Suarez D.L., Swayne D.E.; RL Submitted (APR-2017) to the EMBL/GenBank/DDBJ databases. RN [11] {ECO:0000313|EMBL:PCL83612.1, ECO:0000313|Proteomes:UP000218464} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=C17 {ECO:0000313|EMBL:PCL83612.1, RC ECO:0000313|Proteomes:UP000218464}; RA Veeraraghavan B., Shankar C., Ghafur A.; RT "Colistin resistant K. pneumoniae."; RL Submitted (SEP-2017) to the EMBL/GenBank/DDBJ databases. RN [12] {ECO:0000313|EMBL:PAX11544.1, ECO:0000313|Proteomes:UP000218240} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=WBB417 {ECO:0000313|EMBL:PAX11544.1, RC ECO:0000313|Proteomes:UP000218240}; RA Koh T.H., Abdul Rahman N., Teo J.W., La M.-V., Periaswamy B., RA Chen S.L.; RT "Draft Genome Sequence of a Singapore Klebsiella pneumoniae subsp. RT pnuemoniae isolate DS32358_14 Encoding the Carbapenemase Gene blaVIM- RT 1."; RL Submitted (SEP-2017) to the EMBL/GenBank/DDBJ databases. RN [13] {ECO:0000313|EMBL:AUA49519.1, ECO:0000313|Proteomes:UP000232092} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=NU-CRE047 {ECO:0000313|EMBL:AUA49519.1, RC ECO:0000313|Proteomes:UP000232092}; RA Ozer E.A., Krapp F., Qi C., Hauser A.R.; RT "Complete genome sequence of Klebsiella pneumoniae strain NU-CRE047."; RL Submitted (NOV-2017) to the EMBL/GenBank/DDBJ databases. RN [14] {ECO:0000313|EMBL:PPK23654.1, ECO:0000313|Proteomes:UP000238271} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=PN030E4 {ECO:0000313|EMBL:PPK23654.1, RC ECO:0000313|Proteomes:UP000238271}; RX PubMed=29479347; DOI=.3389/fmicb.2018.00188; RA Founou L., Founou R.C., Allam M., Ismail A., Djoko C.F., Essack S.Y.; RT "Genome Sequencing of Extended-Spectrum ?-Lactamase (ESBL)-Producing RT Klebsiella pneumoniae Isolated from Pigs and Abattoir Workers in RT Cameroon."; RL Front. Microbiol. 9:188-188(2018). RN [15] {ECO:0000313|EMBL:AUY20800.1, ECO:0000313|Proteomes:UP000239813} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=KPNIH48 {ECO:0000313|EMBL:AUY20800.1, RC ECO:0000313|Proteomes:UP000239813}; RA Weingarten R.A., Johnson R.C., Conlan S., Ramsburg A.M., Dekker J.P., RA Lau A.F., Khil P., Odom R.T., Deming C., Park M., Thomas P.J., RA Henderson D.K., Palmore T.N., Segre J.A., Frank K.M.; RT "Genomic Analysis of Hospital Plumbing Reveals Diverse Reservoir of RT Bacterial Plasmids Conferring Carbapenem Resistance."; RL MBio 0:0-0(2018). RN [16] {ECO:0000313|EMBL:AVB70589.1, ECO:0000313|Proteomes:UP000238332} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=NUHL30457 {ECO:0000313|EMBL:AVB70589.1, RC ECO:0000313|Proteomes:UP000238332}; RA Liu Y.; RT "Genome of Klebsiella pneumoniae NUHL3069."; RL Submitted (FEB-2018) to the EMBL/GenBank/DDBJ databases. RN [17] {ECO:0000313|EMBL:AVS25444.1, ECO:0000313|Proteomes:UP000241666} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=CFSAN054110 {ECO:0000313|EMBL:AVS25444.1, RC ECO:0000313|Proteomes:UP000241666}; RA Hoffmann M., Pedersen S.K., Sanchez M., Pettengill J.B., RA Hendriksen R.S.; RT "Genome assemblies for Global Microbial Identifier (GMI) Proficiency RT Testing reference strains."; RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases. RN [18] {ECO:0000313|EMBL:AVO79824.1, ECO:0000313|Proteomes:UP000238712} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=AR_0080 {ECO:0000313|EMBL:AVO79824.1, RC ECO:0000313|Proteomes:UP000238712}; RA Conlan S., Thomas P.J., Mullikin J., Frank K.M., Segre J.A.; RT "Whole genome sequencing of Klebsiella pneumoniae AR_0080."; RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases. CC -!- ENZYME REGULATION: FtsK may regulate the catalytic switch between CC XerC and XerD in the heterotetrameric complex during the two steps CC of the recombination process. {ECO:0000256|HAMAP-Rule:MF_01807}. CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_01807, CC ECO:0000256|SAAS:SAAS00019473}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; CP008929; AIT00307.1; -; Genomic_DNA. DR EMBL; CP013322; ALR26130.1; -; Genomic_DNA. DR EMBL; CP018707; APP57120.1; -; Genomic_DNA. DR EMBL; CP025037; AUA49519.1; -; Genomic_DNA. DR EMBL; CP026392; AUY20800.1; -; Genomic_DNA. DR EMBL; CP026586; AVB70589.1; -; Genomic_DNA. DR EMBL; CP027602; AVO79824.1; -; Genomic_DNA. DR EMBL; CP028180; AVS25444.1; -; Genomic_DNA. DR EMBL; LK022715; CDQ52864.1; -; Genomic_DNA. DR EMBL; LGJJ01000012; KMW85539.1; -; Genomic_DNA. DR EMBL; MTSV01001318; OON35129.1; -; Genomic_DNA. DR EMBL; MPYG03000255; OSU05398.1; -; Genomic_DNA. DR EMBL; MZXR01000046; OXT23834.1; -; Genomic_DNA. DR EMBL; NSMB01000014; PAX11544.1; -; Genomic_DNA. DR EMBL; NXFM01000001; PCL83612.1; -; Genomic_DNA. DR EMBL; PDVM01000039; PPK23654.1; -; Genomic_DNA. DR EMBL; FLXG01000007; SBX92074.1; -; Genomic_DNA. DR RefSeq; WP_004144729.1; NZ_QCWR01000004.1. DR EnsemblBacteria; AIT00307; AIT00307; PMK1_00810. DR EnsemblBacteria; ALR26130; ALR26130; AGG09_18445. DR EnsemblBacteria; KSY13972; KSY13972; APT98_23625. DR EnsemblBacteria; SBX92074; SBX92074; SAMEA3531848_02889. DR EnsemblBacteria; SBY65672; SBY65672; SAMEA3531778_02882. DR KEGG; kpb:FH42_12590; -. DR KEGG; kpne:KU54_004475; -. DR KEGG; kpnu:LI86_04480; -. DR KEGG; kpx:PMK1_00810; -. DR PATRIC; fig|573.1346.peg.1806; -. DR eggNOG; ENOG4105C13; Bacteria. DR eggNOG; COG4974; LUCA. DR KO; K04763; -. DR Proteomes; UP000029666; Chromosome. DR Proteomes; UP000037134; Unassembled WGS sequence. DR Proteomes; UP000053587; Unassembled WGS sequence. DR Proteomes; UP000067608; Chromosome. DR Proteomes; UP000092856; Unassembled WGS sequence. DR Proteomes; UP000184736; Chromosome. DR Proteomes; UP000186691; Unassembled WGS sequence. DR Proteomes; UP000190740; Unassembled WGS sequence. DR Proteomes; UP000215037; Unassembled WGS sequence. DR Proteomes; UP000218240; Unassembled WGS sequence. DR Proteomes; UP000218464; Unassembled WGS sequence. DR Proteomes; UP000232092; Chromosome. DR Proteomes; UP000238271; Unassembled WGS sequence. DR Proteomes; UP000238332; Chromosome. DR Proteomes; UP000238712; Chromosome. DR Proteomes; UP000239813; Chromosome. DR Proteomes; UP000241666; Chromosome. DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW. DR GO; GO:0009037; F:tyrosine-based site-specific recombinase activity; IEA:UniProtKB-UniRule. DR GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW. DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW. DR GO; GO:0007059; P:chromosome segregation; IEA:UniProtKB-UniRule. DR GO; GO:0006313; P:transposition, DNA-mediated; IEA:UniProtKB-UniRule. DR Gene3D; 1.10.150.130; -; 1. DR Gene3D; 1.10.443.10; -; 1. DR HAMAP; MF_01808; Recomb_XerC_XerD; 1. DR HAMAP; MF_01807; Recomb_XerD; 1. DR InterPro; IPR011010; DNA_brk_join_enz. DR InterPro; IPR013762; Integrase-like_cat_sf. DR InterPro; IPR002104; Integrase_catalytic. DR InterPro; IPR010998; Integrase_recombinase_N. DR InterPro; IPR004107; Integrase_SAM-like_N. DR InterPro; IPR011932; Recomb_XerD. DR InterPro; IPR023009; Tyrosine_recombinase_XerC/XerD. DR Pfam; PF02899; Phage_int_SAM_1; 1. DR Pfam; PF00589; Phage_integrase; 1. DR SUPFAM; SSF56349; SSF56349; 1. DR TIGRFAMs; TIGR02225; recomb_XerD; 1. PE 3: Inferred from homology; KW Cell cycle {ECO:0000256|HAMAP-Rule:MF_01807, KW ECO:0000256|SAAS:SAAS00608023}; KW Cell division {ECO:0000256|HAMAP-Rule:MF_01807, KW ECO:0000256|SAAS:SAAS00608024}; KW Chromosome partition {ECO:0000256|HAMAP-Rule:MF_01807, KW ECO:0000256|SAAS:SAAS00608018}; KW Complete proteome {ECO:0000313|Proteomes:UP000029666, KW ECO:0000313|Proteomes:UP000037134, ECO:0000313|Proteomes:UP000053587, KW ECO:0000313|Proteomes:UP000067608}; KW Cytoplasm {ECO:0000256|HAMAP-Rule:MF_01807, KW ECO:0000256|SAAS:SAAS00019482}; KW DNA integration {ECO:0000256|HAMAP-Rule:MF_01807, KW ECO:0000256|SAAS:SAAS00019141}; KW DNA recombination {ECO:0000256|HAMAP-Rule:MF_01807, KW ECO:0000256|SAAS:SAAS00298318}; KW DNA-binding {ECO:0000256|HAMAP-Rule:MF_01807, KW ECO:0000256|SAAS:SAAS00019121}. FT DOMAIN 8 90 Integrase_SAM-like_N. {ECO:0000259|Pfam: FT PF02899}. FT DOMAIN 113 284 Phage_integrase. {ECO:0000259|Pfam: FT PF00589}. FT ACT_SITE 148 148 {ECO:0000256|HAMAP-Rule:MF_01807}. FT ACT_SITE 172 172 {ECO:0000256|HAMAP-Rule:MF_01807}. FT ACT_SITE 244 244 {ECO:0000256|HAMAP-Rule:MF_01807}. FT ACT_SITE 247 247 {ECO:0000256|HAMAP-Rule:MF_01807}. FT ACT_SITE 270 270 {ECO:0000256|HAMAP-Rule:MF_01807}. FT ACT_SITE 279 279 O-(3'-phospho-DNA)-tyrosine intermediate. FT {ECO:0000256|HAMAP-Rule:MF_01807}. SQ SEQUENCE 298 AA; 33967 MW; DF893A2E8C2D2B88 CRC64; MKQDLALIEQ FLDALWLERN LAENTLSAYR RDLTMLVEWL HHRGLSLASV GSDDLQALLA ERQSGGYKAT STARLLSAVR RFFQHLYREK IRPDDPSALL ASPKLPQRLP KDLSEAQVER LLQAPLVEQP LELRDKAMLE VLYATGLRVS ELVGLTMSDI SLRQGVLRVV GKGNKERLVP LGEEAVLWVE NYLEYGRPWL LNGVASDVLF PSQRAQQMTR QTFWHRIKHY AVLAGIDSEK LSPHVLRHAF ATHLLNHGAD LRVVQMLLGH SDLSTTQIYT HVATERLRQL HQQHHPRA //