ID A0A060VEM3_KLEPN Unreviewed; 298 AA. AC A0A060VEM3; DT 03-SEP-2014, integrated into UniProtKB/TrEMBL. DT 03-SEP-2014, sequence version 1. DT 20-DEC-2017, entry version 38. DE RecName: Full=Tyrosine recombinase XerD {ECO:0000256|HAMAP-Rule:MF_01807}; GN Name=xerD {ECO:0000256|HAMAP-Rule:MF_01807, GN ECO:0000313|EMBL:CDQ52864.1}; GN Synonyms=xerD_1 {ECO:0000313|EMBL:AIT00307.1}; GN ORFNames=AGG09_18445 {ECO:0000313|EMBL:ALR26130.1}, AM390_24765 GN {ECO:0000313|EMBL:ARX46866.1}, AM447_16295 GN {ECO:0000313|EMBL:ARA47605.1}, B1727_10085 GN {ECO:0000313|EMBL:OXT23834.1}, B8011_11065 GN {ECO:0000313|EMBL:OVH58024.1}, BL102_0023570 GN {ECO:0000313|EMBL:OSW35288.1}, BU230_34595 GN {ECO:0000313|EMBL:OON35129.1}, BVX91_20715 GN {ECO:0000313|EMBL:PAX11544.1}, CEO55_12345 GN {ECO:0000313|EMBL:OZL86300.1}, CIT28_17580 GN {ECO:0000313|EMBL:OZN57798.1}, CP905_13015 GN {ECO:0000313|EMBL:PCN39436.1}, KpST82_3931 GN {ECO:0000313|EMBL:CDQ52864.1}, PMK1_00810 GN {ECO:0000313|EMBL:AIT00307.1}, SAMEA3531778_02882 GN {ECO:0000313|EMBL:SBY65672.1}, SAMEA3531848_02889 GN {ECO:0000313|EMBL:SBX92074.1}, SM57_03567 GN {ECO:0000313|EMBL:KMW85539.1}; OS Klebsiella pneumoniae. OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales; OC Enterobacteriaceae; Klebsiella. OX NCBI_TaxID=573 {ECO:0000313|EMBL:CDQ52864.1, ECO:0000313|Proteomes:UP000053587}; RN [1] {ECO:0000313|EMBL:AIT00307.1, ECO:0000313|Proteomes:UP000029666} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=PMK1 {ECO:0000313|EMBL:AIT00307.1, RC ECO:0000313|Proteomes:UP000029666}; RX PubMed=25267672; RA Stoesser N., Giess A., Batty E.M., Sheppard A.E., Walker A.S., RA Wilson D.J., Didelot X., Bashir A., Sebra R., Kasarskis A., RA Sthapit B., Shakya M., Kelly D., Pollard A.J., Peto T.E., Crook D.W., RA Donnelly P., Thorson S., Amatya P., Joshi S.; RT "Genome Sequencing of an Extended Series of NDM-Producing Klebsiella RT pneumoniae Isolates from Neonatal Infections in a Nepali Hospital RT Characterizes the Extent of Community- versus Hospital-Associated RT Transmission in an Endemic Setting."; RL Antimicrob. Agents Chemother. 58:7347-7357(2014). RN [2] {ECO:0000313|EMBL:CDQ52864.1, ECO:0000313|Proteomes:UP000053587} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=SB3193 {ECO:0000313|EMBL:CDQ52864.1, RC ECO:0000313|Proteomes:UP000053587}; RA Genoscope - CEA; RL Submitted (MAY-2014) to the EMBL/GenBank/DDBJ databases. RN [3] {ECO:0000313|EMBL:KMW85539.1, ECO:0000313|Proteomes:UP000037134} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=MGH83 {ECO:0000313|EMBL:KMW85539.1, RC ECO:0000313|Proteomes:UP000037134}; RG The Broad Institute Genomics Platform; RG The Broad Institute Genome Sequencing Center for Infectious Disease; RA Earl A.M., Onderdonk A.B., Kirby J., Ferraro M.J., Huang S., RA Spencer M., Fodor A., Hooper D., Dekker J., O'Brien T., Quan V., RA Gombosev A., Delaney M., Dubois A., Ernst C., Kim D.S., Rossman W., RA Gohs F., Petruso H., Nozar T., Mougeot F., Manson-Mcguire A., RA Young S., Abouelleil A., Cao P., Chapman S.B., Griggs A., Priest M., RA Shea T., Wortman I., Wortman J.R., Nusbaum C., Birren B.; RT "The Genome Sequence of None."; RL Submitted (JUN-2015) to the EMBL/GenBank/DDBJ databases. RN [4] {ECO:0000313|Proteomes:UP000067608} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=CAV1193 {ECO:0000313|Proteomes:UP000067608}; RA Sheppard A.E., Stoesser N., Sebra R., Kasarskis A., Deikus G., RA Anson L., Walker A.S., Peto T.E., Crook D.W., Mathers A.J.; RT "Complete Genome Sequence of the KPC-producing Klebsiella pneumoniae RT strain CAV1193."; RL Submitted (NOV-2015) to the EMBL/GenBank/DDBJ databases. RN [5] {ECO:0000313|EMBL:ALR26130.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=CAV1193 {ECO:0000313|EMBL:ALR26130.1}; RX PubMed=26823590; RA Sheppard A.E., Stoesser N., Sebra R., Kasarskis A., Deikus G., RA Anson L., Walker A.S., Peto T.E., Crook D.W., Mathers A.J.; RT "Complete Genome Sequence of KPC-Producing Klebsiella pneumoniae RT Strain CAV1193."; RL Genome Announc. 4:e01649-15(2016). RN [6] {ECO:0000313|EMBL:SBX92074.1, ECO:0000313|Proteomes:UP000092856, ECO:0000313|Proteomes:UP000092889} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=PB463 {ECO:0000313|EMBL:SBX92074.1, RC ECO:0000313|Proteomes:UP000092856}, and PB5 RC {ECO:0000313|EMBL:SBY65672.1, ECO:0000313|Proteomes:UP000092889}; RG Pathogen Informatics; RL Submitted (JUL-2016) to the EMBL/GenBank/DDBJ databases. RN [7] {ECO:0000313|EMBL:OON35129.1, ECO:0000313|Proteomes:UP000190740} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=MB369 {ECO:0000313|EMBL:OON35129.1, RC ECO:0000313|Proteomes:UP000190740}; RA Mah S.A., Swanson W.J., Moy G.W., Vacquier V.D.; RL Submitted (JAN-2017) to the EMBL/GenBank/DDBJ databases. RN [8] {ECO:0000313|EMBL:OXT23834.1, ECO:0000313|Proteomes:UP000215037} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=OK8 {ECO:0000313|EMBL:OXT23834.1, RC ECO:0000313|Proteomes:UP000215037}; RA Nagamalleswari E., Nagaraja V.; RT "Draft genome analysis of Klebsiella pneumoniae OK8."; RL Submitted (MAR-2017) to the EMBL/GenBank/DDBJ databases. RN [9] {ECO:0000313|EMBL:ARA47605.1, ECO:0000313|Proteomes:UP000190083} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=AR_0068 {ECO:0000313|EMBL:ARA47605.1, RC ECO:0000313|Proteomes:UP000190083}; RA Conlan S., Thomas P.J., Mullikin J., Frank K.M., Segre J.A.; RT "Whole genome sequencing of Klebsiella pneumoniae AR_0068."; RL Submitted (MAR-2017) to the EMBL/GenBank/DDBJ databases. RN [10] {ECO:0000313|EMBL:OVH58024.1, ECO:0000313|Proteomes:UP000195917} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=42812 {ECO:0000313|EMBL:OVH58024.1, RC ECO:0000313|Proteomes:UP000195917}; RA Afonso C.L., Miller P.J., Scott M.A., Spackman E., Goraichik I., RA Dimitrov K.M., Suarez D.L., Swayne D.E.; RL Submitted (MAR-2017) to the EMBL/GenBank/DDBJ databases. RN [11] {ECO:0000313|EMBL:OSW35288.1, ECO:0000313|Proteomes:UP000186660} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=682_1613 {ECO:0000313|EMBL:OSW35288.1, RC ECO:0000313|Proteomes:UP000186660}; RA Afonso C.L., Miller P.J., Scott M.A., Spackman E., Goraichik I., RA Dimitrov K.M., Suarez D.L., Swayne D.E.; RL Submitted (APR-2017) to the EMBL/GenBank/DDBJ databases. RN [12] {ECO:0000313|EMBL:ARX46866.1, ECO:0000313|Proteomes:UP000195656} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=AR_0143 {ECO:0000313|EMBL:ARX46866.1, RC ECO:0000313|Proteomes:UP000195656}; RA Conlan S., Thomas P.J., Mullikin J., Frank K.M., Segre J.A.; RT "Whole genome sequencing of Klebsiella pneumoniae AR_0143."; RL Submitted (JUN-2017) to the EMBL/GenBank/DDBJ databases. RN [13] {ECO:0000313|EMBL:OZL86300.1, ECO:0000313|Proteomes:UP000216878} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=L222 {ECO:0000313|EMBL:OZL86300.1, RC ECO:0000313|Proteomes:UP000216878}; RA Zheng B.; RT "Whole-Genome Sequencing Reveals the Clonal Transmission of Intestinal RT Carriage of Carbapenemase-producing Enterobacteriaceae in Hospitalized RT Patients with Diarrhea."; RL Submitted (JUL-2017) to the EMBL/GenBank/DDBJ databases. RN [14] {ECO:0000313|EMBL:OZN57798.1, ECO:0000313|Proteomes:UP000216471} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=SCPM-O-B-8045 {ECO:0000313|EMBL:OZN57798.1}, and SCPM-O-B-8045 RC (KPB-1470/16) {ECO:0000313|Proteomes:UP000216471}; RA Sun Z.S., Albrecht U., Echele G., Lee C.C.; RL Submitted (JUL-2017) to the EMBL/GenBank/DDBJ databases. RN [15] {ECO:0000313|EMBL:PAX11544.1, ECO:0000313|Proteomes:UP000218240} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=WBB417 {ECO:0000313|EMBL:PAX11544.1, RC ECO:0000313|Proteomes:UP000218240}; RA Koh T.H., Abdul Rahman N., Teo J.W., La M.-V., Periaswamy B., RA Chen S.L.; RT "Draft Genome Sequence of a Singapore Klebsiella pneumoniae subsp. RT pnuemoniae isolate DS32358_14 Encoding the Carbapenemase Gene blaVIM- RT 1."; RL Submitted (SEP-2017) to the EMBL/GenBank/DDBJ databases. RN [16] {ECO:0000313|EMBL:PCN39436.1, ECO:0000313|Proteomes:UP000218797} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=70 {ECO:0000313|EMBL:PCN39436.1, RC ECO:0000313|Proteomes:UP000218797}; RA Agyepong N., Janice J., Samuelsen O., Owusu-Ofori A., Sundsfjord A., RA Essack S., Pedersen T.; RT "Mdr eskape-Ghana."; RL Submitted (SEP-2017) to the EMBL/GenBank/DDBJ databases. CC -!- ENZYME REGULATION: FtsK may regulate the catalytic switch between CC XerC and XerD in the heterotetrameric complex during the two steps CC of the recombination process. {ECO:0000256|HAMAP-Rule:MF_01807}. CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_01807, CC ECO:0000256|SAAS:SAAS00019473}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; CP008929; AIT00307.1; -; Genomic_DNA. DR EMBL; CP013322; ALR26130.1; -; Genomic_DNA. DR EMBL; CP020067; ARA47605.1; -; Genomic_DNA. DR EMBL; CP021708; ARX46866.1; -; Genomic_DNA. DR EMBL; LK022715; CDQ52864.1; -; Genomic_DNA. DR EMBL; LGJJ01000012; KMW85539.1; -; Genomic_DNA. DR EMBL; MTSV01001318; OON35129.1; -; Genomic_DNA. DR EMBL; MPXL03000099; OSW35288.1; -; Genomic_DNA. DR EMBL; NDCY01000051; OVH58024.1; -; Genomic_DNA. DR EMBL; MZXR01000046; OXT23834.1; -; Genomic_DNA. DR EMBL; NLDJ01000010; OZL86300.1; -; Genomic_DNA. DR EMBL; NPII01000013; OZN57798.1; -; Genomic_DNA. DR EMBL; NSMB01000014; PAX11544.1; -; Genomic_DNA. DR EMBL; NXHU01000009; PCN39436.1; -; Genomic_DNA. DR EMBL; FLXG01000007; SBX92074.1; -; Genomic_DNA. DR EMBL; FLVW01000004; SBY65672.1; -; Genomic_DNA. DR RefSeq; WP_004144729.1; NZ_NQLO01000033.1. DR EnsemblBacteria; AIT00307; AIT00307; PMK1_00810. DR EnsemblBacteria; ALR26130; ALR26130; AGG09_18445. DR EnsemblBacteria; KSY13972; KSY13972; APT98_23625. DR EnsemblBacteria; SBX92074; SBX92074; SAMEA3531848_02889. DR EnsemblBacteria; SBY65672; SBY65672; SAMEA3531778_02882. DR KEGG; kpb:FH42_12590; -. DR KEGG; kpne:KU54_004475; -. DR KEGG; kpnu:LI86_04480; -. DR KEGG; kpx:PMK1_00810; -. DR PATRIC; fig|573.1346.peg.1806; -. DR eggNOG; ENOG4105C13; Bacteria. DR eggNOG; COG4974; LUCA. DR KO; K04763; -. DR Proteomes; UP000029666; Chromosome. DR Proteomes; UP000037134; Unassembled WGS sequence. DR Proteomes; UP000053587; Unassembled WGS sequence. DR Proteomes; UP000067608; Chromosome. DR Proteomes; UP000092856; Unassembled WGS sequence. DR Proteomes; UP000092889; Unassembled WGS sequence. DR Proteomes; UP000186660; Unassembled WGS sequence. DR Proteomes; UP000190083; Chromosome. DR Proteomes; UP000190740; Unassembled WGS sequence. DR Proteomes; UP000195656; Chromosome. DR Proteomes; UP000195917; Unassembled WGS sequence. DR Proteomes; UP000215037; Unassembled WGS sequence. DR Proteomes; UP000216471; Unassembled WGS sequence. DR Proteomes; UP000216878; Unassembled WGS sequence. DR Proteomes; UP000218240; Unassembled WGS sequence. DR Proteomes; UP000218797; Unassembled WGS sequence. DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW. DR GO; GO:0009037; F:tyrosine-based site-specific recombinase activity; IEA:UniProtKB-UniRule. DR GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW. DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW. DR GO; GO:0007059; P:chromosome segregation; IEA:UniProtKB-UniRule. DR GO; GO:0006313; P:transposition, DNA-mediated; IEA:UniProtKB-UniRule. DR Gene3D; 1.10.150.130; -; 1. DR Gene3D; 1.10.443.10; -; 1. DR HAMAP; MF_01808; Recomb_XerC_XerD; 1. DR HAMAP; MF_01807; Recomb_XerD; 1. DR InterPro; IPR011010; DNA_brk_join_enz. DR InterPro; IPR013762; Integrase-like_cat_sf. DR InterPro; IPR002104; Integrase_catalytic. DR InterPro; IPR010998; Integrase_recombinase_N. DR InterPro; IPR004107; Integrase_SAM-like_N. DR InterPro; IPR011932; Recomb_XerD. DR InterPro; IPR023009; Tyrosine_recombinase_XerC/XerD. DR Pfam; PF02899; Phage_int_SAM_1; 1. DR Pfam; PF00589; Phage_integrase; 1. DR SUPFAM; SSF56349; SSF56349; 1. DR TIGRFAMs; TIGR02225; recomb_XerD; 1. PE 3: Inferred from homology; KW Cell cycle {ECO:0000256|HAMAP-Rule:MF_01807, KW ECO:0000256|SAAS:SAAS00608023}; KW Cell division {ECO:0000256|HAMAP-Rule:MF_01807, KW ECO:0000256|SAAS:SAAS00608024}; KW Chromosome partition {ECO:0000256|HAMAP-Rule:MF_01807, KW ECO:0000256|SAAS:SAAS00608018}; KW Complete proteome {ECO:0000313|Proteomes:UP000029666, KW ECO:0000313|Proteomes:UP000037134, ECO:0000313|Proteomes:UP000053587, KW ECO:0000313|Proteomes:UP000067608}; KW Cytoplasm {ECO:0000256|HAMAP-Rule:MF_01807, KW ECO:0000256|SAAS:SAAS00019482}; KW DNA integration {ECO:0000256|HAMAP-Rule:MF_01807, KW ECO:0000256|SAAS:SAAS00019141}; KW DNA recombination {ECO:0000256|HAMAP-Rule:MF_01807, KW ECO:0000256|SAAS:SAAS00298318}; KW DNA-binding {ECO:0000256|HAMAP-Rule:MF_01807, KW ECO:0000256|SAAS:SAAS00019121}. FT DOMAIN 8 90 Integrase_SAM-like_N. {ECO:0000259|Pfam: FT PF02899}. FT DOMAIN 113 284 Phage_integrase. {ECO:0000259|Pfam: FT PF00589}. FT ACT_SITE 148 148 {ECO:0000256|HAMAP-Rule:MF_01807}. FT ACT_SITE 172 172 {ECO:0000256|HAMAP-Rule:MF_01807}. FT ACT_SITE 244 244 {ECO:0000256|HAMAP-Rule:MF_01807}. FT ACT_SITE 247 247 {ECO:0000256|HAMAP-Rule:MF_01807}. FT ACT_SITE 270 270 {ECO:0000256|HAMAP-Rule:MF_01807}. FT ACT_SITE 279 279 O-(3'-phospho-DNA)-tyrosine intermediate. FT {ECO:0000256|HAMAP-Rule:MF_01807}. SQ SEQUENCE 298 AA; 33967 MW; DF893A2E8C2D2B88 CRC64; MKQDLALIEQ FLDALWLERN LAENTLSAYR RDLTMLVEWL HHRGLSLASV GSDDLQALLA ERQSGGYKAT STARLLSAVR RFFQHLYREK IRPDDPSALL ASPKLPQRLP KDLSEAQVER LLQAPLVEQP LELRDKAMLE VLYATGLRVS ELVGLTMSDI SLRQGVLRVV GKGNKERLVP LGEEAVLWVE NYLEYGRPWL LNGVASDVLF PSQRAQQMTR QTFWHRIKHY AVLAGIDSEK LSPHVLRHAF ATHLLNHGAD LRVVQMLLGH SDLSTTQIYT HVATERLRQL HQQHHPRA //