ID A0A060VEM3_KLEPN Unreviewed; 298 AA. AC A0A060VEM3; DT 03-SEP-2014, integrated into UniProtKB/TrEMBL. DT 03-SEP-2014, sequence version 1. DT 11-MAY-2016, entry version 21. DE RecName: Full=Tyrosine recombinase XerD {ECO:0000256|HAMAP-Rule:MF_01807}; GN Name=xerD {ECO:0000256|HAMAP-Rule:MF_01807, GN ECO:0000313|EMBL:CDQ52864.1}; GN Synonyms=xerD_1 {ECO:0000313|EMBL:AIT00307.1}, xerD_3 GN {ECO:0000313|EMBL:KUF59925.1}; GN ORFNames=AGG09_18445 {ECO:0000313|EMBL:ALR26130.1}, AOT21_03506 GN {ECO:0000313|EMBL:KUF59925.1}, APT98_23625 GN {ECO:0000313|EMBL:KSY13972.1}, KpST82_3931 GN {ECO:0000313|EMBL:CDQ52864.1}, PMK1_00810 GN {ECO:0000313|EMBL:AIT00307.1}; OS Klebsiella pneumoniae. OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacteriales; OC Enterobacteriaceae; Klebsiella. OX NCBI_TaxID=573 {ECO:0000313|EMBL:CDQ52864.1, ECO:0000313|Proteomes:UP000053587}; RN [1] {ECO:0000313|EMBL:AIT00307.1, ECO:0000313|Proteomes:UP000029666} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=PMK1 {ECO:0000313|EMBL:AIT00307.1, RC ECO:0000313|Proteomes:UP000029666}; RX PubMed=25267672; RA Stoesser N., Giess A., Batty E.M., Sheppard A.E., Walker A.S., RA Wilson D.J., Didelot X., Bashir A., Sebra R., Kasarskis A., RA Sthapit B., Shakya M., Kelly D., Pollard A.J., Peto T.E., Crook D.W., RA Donnelly P., Thorson S., Amatya P., Joshi S.; RT "Genome Sequencing of an Extended Series of NDM-Producing Klebsiella RT pneumoniae Isolates from Neonatal Infections in a Nepali Hospital RT Characterizes the Extent of Community- versus Hospital-Associated RT Transmission in an Endemic Setting."; RL Antimicrob. Agents Chemother. 58:7347-7357(2014). RN [2] {ECO:0000313|EMBL:CDQ52864.1, ECO:0000313|Proteomes:UP000053587} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=SB3193 {ECO:0000313|EMBL:CDQ52864.1, RC ECO:0000313|Proteomes:UP000053587}; RA Genoscope - CEA; RL Submitted (MAY-2014) to the EMBL/GenBank/DDBJ databases. RN [3] {ECO:0000313|EMBL:KSY13972.1, ECO:0000313|Proteomes:UP000053953} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=50667959 {ECO:0000313|EMBL:KSY13972.1, RC ECO:0000313|Proteomes:UP000053953}; RA Millard Andrew; RL Submitted (OCT-2015) to the EMBL/GenBank/DDBJ databases. RN [4] {ECO:0000313|Proteomes:UP000067608} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=CAV1193 {ECO:0000313|Proteomes:UP000067608}; RA Sheppard A.E., Stoesser N., Sebra R., Kasarskis A., Deikus G., RA Anson L., Walker A.S., Peto T.E., Crook D.W., Mathers A.J.; RT "Complete Genome Sequence of the KPC-producing Klebsiella pneumoniae RT strain CAV1193."; RL Submitted (NOV-2015) to the EMBL/GenBank/DDBJ databases. RN [5] {ECO:0000313|EMBL:KUF59925.1, ECO:0000313|Proteomes:UP000054418} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=OC217 {ECO:0000313|EMBL:KUF59925.1, RC ECO:0000313|Proteomes:UP000054418}; RA Lopez L.L., Rusconi B., Mclaughlin M., Qi C., Scheetz M.H., Seshu J., RA Eppinger M.; RT "Genome sequences of six carbapenem-resistant clinical isolates of RT Klebsiella pneumoniae."; RL Submitted (DEC-2015) to the EMBL/GenBank/DDBJ databases. RN [6] {ECO:0000313|EMBL:ALR26130.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=CAV1193 {ECO:0000313|EMBL:ALR26130.1}; RX PubMed=26823590; RA Sheppard A.E., Stoesser N., Sebra R., Kasarskis A., Deikus G., RA Anson L., Walker A.S., Peto T.E., Crook D.W., Mathers A.J.; RT "Complete Genome Sequence of KPC-Producing Klebsiella pneumoniae RT Strain CAV1193."; RL Genome Announc. 4:e01649-15(2016). CC -!- ENZYME REGULATION: FtsK may regulate the catalytic switch between CC XerC and XerD in the heterotetrameric complex during the two steps CC of the recombination process. {ECO:0000256|HAMAP-Rule:MF_01807}. CC -!- SUBUNIT: Forms a cyclic heterotetrameric complex composed of two CC molecules of XerC and two molecules of XerD, in which XerC CC interacts with XerD via its C-terminal region, XerD interacts with CC XerC via its C-terminal region and so on. {ECO:0000256|HAMAP- CC Rule:MF_01807}. CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_01807, CC ECO:0000256|SAAS:SAAS00019473}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; CP008929; AIT00307.1; -; Genomic_DNA. DR EMBL; CP013322; ALR26130.1; -; Genomic_DNA. DR EMBL; LK022715; CDQ52864.1; -; Genomic_DNA. DR EMBL; LNHV01000094; KSY13972.1; -; Genomic_DNA. DR EMBL; LOEF01000023; KUF59925.1; -; Genomic_DNA. DR RefSeq; WP_004144729.1; NZ_LSTN01000105.1. DR STRING; 272620.KPN_03322; -. DR EnsemblBacteria; AIT00307; AIT00307; PMK1_00810. DR EnsemblBacteria; AKK87009; AKK87009; ABY63_14085. DR EnsemblBacteria; AKL30106; AKL30106; AB186_18335. DR EnsemblBacteria; AKL44805; AKL44805; AB187_02540. DR EnsemblBacteria; CED77671; CED77671; KPLM21_90091. DR EnsemblBacteria; CEN65736; CEN65736; KPOL2_01260. DR EnsemblBacteria; CEO85281; CEO85281; KPST15NDM1_01461. DR EnsemblBacteria; CTQ29780; CTQ29780; CH1034_290013. DR EnsemblBacteria; KMH12063; KMH12063; SM66_04130. DR EnsemblBacteria; KMH50069; KMH50069; SM73_01987. DR EnsemblBacteria; KMW83565; KMW83565; SM91_03422. DR EnsemblBacteria; KMW85539; KMW85539; SM57_03567. DR EnsemblBacteria; KMW92209; KMW92209; SM51_03738. DR EnsemblBacteria; KMX01822; KMX01822; SM50_01743. DR EnsemblBacteria; KMX05683; KMX05683; SM49_03240. DR EnsemblBacteria; KMX12958; KMX12958; SM23_01746. DR EnsemblBacteria; KMX14396; KMX14396; SM08_03736. DR EnsemblBacteria; KMX19913; KMX19913; SM06_03871. DR EnsemblBacteria; KMX31372; KMX31372; SL97_01592. DR EnsemblBacteria; KMX35391; KMX35391; SL88_01743. DR EnsemblBacteria; KMX37904; KMX37904; SL81_03556. DR EnsemblBacteria; KMX42546; KMX42546; SL85_03365. DR EnsemblBacteria; KMX48616; KMX48616; SL48_03430. DR EnsemblBacteria; KMX55394; KMX55394; SL36_03713. DR EnsemblBacteria; KMX56618; KMX56618; SL42_01744. DR EnsemblBacteria; KMX68701; KMX68701; SL32_01749. DR EnsemblBacteria; KMX73391; KMX73391; SL31_01751. DR EnsemblBacteria; KMX77189; KMX77189; SL20_01922. DR EnsemblBacteria; KMX83631; KMX83631; SK99_03509. DR EnsemblBacteria; KMX86255; KMX86255; SK98_03652. DR EnsemblBacteria; KMX92414; KMX92414; SL15_01750. DR EnsemblBacteria; KOP07955; KOP07955; AMC97_23845. DR EnsemblBacteria; KOP10085; KOP10085; AMC96_23120. DR EnsemblBacteria; KOP14880; KOP14880; AMC95_13890. DR KEGG; kpb:FH42_12590; -. DR KEGG; kpne:KU54_004475; -. DR KEGG; kpnu:LI86_04480; -. DR KEGG; kpx:PMK1_00810; -. DR eggNOG; ENOG4105C13; Bacteria. DR eggNOG; COG4974; LUCA. DR KO; K04763; -. DR Proteomes; UP000029666; Chromosome. DR Proteomes; UP000053587; Unassembled WGS sequence. DR Proteomes; UP000053953; Unassembled WGS sequence. DR Proteomes; UP000054418; Unassembled WGS sequence. DR Proteomes; UP000067608; Chromosome. DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW. DR GO; GO:0009037; F:tyrosine-based site-specific recombinase activity; IEA:UniProtKB-HAMAP. DR GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW. DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW. DR GO; GO:0007059; P:chromosome segregation; IEA:UniProtKB-HAMAP. DR GO; GO:0006313; P:transposition, DNA-mediated; IEA:UniProtKB-HAMAP. DR Gene3D; 1.10.150.130; -; 1. DR Gene3D; 1.10.443.10; -; 1. DR HAMAP; MF_01807; Recomb_XerD; 1. DR HAMAP; MF_01808; Recomb_XerC; 1. DR InterPro; IPR011010; DNA_brk_join_enz. DR InterPro; IPR013762; Integrase-like_cat. DR InterPro; IPR002104; Integrase_catalytic. DR InterPro; IPR023109; Integrase_recombinase_N. DR InterPro; IPR004107; Integrase_SAM-like_N. DR InterPro; IPR011932; Recomb_XerD. DR InterPro; IPR023009; Tyrosine_recombinase_XerC/XerD. DR Pfam; PF02899; Phage_int_SAM_1; 1. DR Pfam; PF00589; Phage_integrase; 1. DR SUPFAM; SSF56349; SSF56349; 1. DR TIGRFAMs; TIGR02225; recomb_XerD; 1. PE 3: Inferred from homology; KW Cell cycle {ECO:0000256|HAMAP-Rule:MF_01807, KW ECO:0000256|SAAS:SAAS00444047}; KW Cell division {ECO:0000256|HAMAP-Rule:MF_01807, KW ECO:0000256|SAAS:SAAS00444057}; KW Chromosome partition {ECO:0000256|HAMAP-Rule:MF_01807, KW ECO:0000256|SAAS:SAAS00444068}; KW Complete proteome {ECO:0000313|Proteomes:UP000029666, KW ECO:0000313|Proteomes:UP000053587, ECO:0000313|Proteomes:UP000053953, KW ECO:0000313|Proteomes:UP000054418}; KW Cytoplasm {ECO:0000256|HAMAP-Rule:MF_01807, KW ECO:0000256|SAAS:SAAS00424238}; KW DNA integration {ECO:0000256|HAMAP-Rule:MF_01807, KW ECO:0000256|SAAS:SAAS00424142}; KW DNA recombination {ECO:0000256|HAMAP-Rule:MF_01807, KW ECO:0000256|SAAS:SAAS00424218}; KW DNA-binding {ECO:0000256|HAMAP-Rule:MF_01807, KW ECO:0000256|SAAS:SAAS00424103}. FT DOMAIN 8 90 Integrase_SAM-like_N. {ECO:0000259|Pfam: FT PF02899}. FT DOMAIN 113 284 Phage_integrase. {ECO:0000259|Pfam: FT PF00589}. FT ACT_SITE 148 148 {ECO:0000256|HAMAP-Rule:MF_01807}. FT ACT_SITE 172 172 {ECO:0000256|HAMAP-Rule:MF_01807}. FT ACT_SITE 244 244 {ECO:0000256|HAMAP-Rule:MF_01807}. FT ACT_SITE 247 247 {ECO:0000256|HAMAP-Rule:MF_01807}. FT ACT_SITE 270 270 {ECO:0000256|HAMAP-Rule:MF_01807}. FT ACT_SITE 279 279 O-(3'-phospho-DNA)-tyrosine intermediate. FT {ECO:0000256|HAMAP-Rule:MF_01807}. SQ SEQUENCE 298 AA; 33967 MW; DF893A2E8C2D2B88 CRC64; MKQDLALIEQ FLDALWLERN LAENTLSAYR RDLTMLVEWL HHRGLSLASV GSDDLQALLA ERQSGGYKAT STARLLSAVR RFFQHLYREK IRPDDPSALL ASPKLPQRLP KDLSEAQVER LLQAPLVEQP LELRDKAMLE VLYATGLRVS ELVGLTMSDI SLRQGVLRVV GKGNKERLVP LGEEAVLWVE NYLEYGRPWL LNGVASDVLF PSQRAQQMTR QTFWHRIKHY AVLAGIDSEK LSPHVLRHAF ATHLLNHGAD LRVVQMLLGH SDLSTTQIYT HVATERLRQL HQQHHPRA //