ID A0A060VCZ1_HUMAN Unreviewed; 339 AA. AC A0A060VCZ1; DT 03-SEP-2014, integrated into UniProtKB/TrEMBL. DT 03-SEP-2014, sequence version 1. DT 16-SEP-2015, entry version 10. DE SubName: Full=MHC class I antigen {ECO:0000313|EMBL:CDQ51666.1}; DE Flags: Fragment; GN Name=HLA-A {ECO:0000313|EMBL:CDQ51666.1}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606 {ECO:0000313|EMBL:CDQ51666.1}; RN [1] {ECO:0000313|EMBL:CDQ51666.1} RP NUCLEOTIDE SEQUENCE. RA Albrecht V., Boehme I., Schmidt A.H.; RT "Characterisation and Confirmation of new HLA-Alleles found by DKMS RT Life Science Lab."; RL Submitted (SEP-2014) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. {ECO:0000256|SAAS:SAAS00281819}. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC -!- SIMILARITY: Contains Ig-like C1-type (immunoglobulin-like) domain. CC {ECO:0000256|SAAS:SAAS00291809}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; LK021985; CDQ51666.1; -; Genomic_DNA. DR STRING; 9606.ENSP00000366005; -. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0042612; C:MHC class I protein complex; IEA:UniProtKB-KW. DR GO; GO:0042605; F:peptide antigen binding; IEA:InterPro. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IEA:UniProtKB-KW. DR GO; GO:0006955; P:immune response; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR027648; MHC_I_a. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Disulfide bond {ECO:0000256|SAAS:SAAS00281758}; KW Immunity {ECO:0000256|SAAS:SAAS00292276}; KW Membrane {ECO:0000256|SAAS:SAAS00281753}; KW MHC I {ECO:0000256|SAAS:SAAS00291591}; KW Transmembrane {ECO:0000256|SAAS:SAAS00281848}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00281807}. FT NON_TER 1 1 {ECO:0000313|EMBL:CDQ51666.1}. FT NON_TER 339 339 {ECO:0000313|EMBL:CDQ51666.1}. SQ SEQUENCE 339 AA; 38166 MW; AB02D42AE276F555 CRC64; SHSMRYFFTS VSRPGRGEPR FIAVGYVDDT QFVRFDSDAA SQKMEPRAPW IEQEGPEYWD QETRNMKAHS QTDRANLGTL RGYYNQSEDG SHTIQIMYGC DVGPDGRFLR GYRQDAYDGK DYIALNEDLR SWTAADMAAQ ITKRKWEAVH AAEQRRVYLE GRCVDGLRRY LENGKETLQR TDPPKTHMTH HPISDHEATL RCWALGFYPA EITLTWQRDG EDQTQDTELV ETRPAGDGTF QKWAAVVVPS GEEQRYTCHV QHEGLPKPLT LRWELSSQPT IPIVGIIAGL VLLGAVITGA VVAAVMWRRK SSDRKGGSYT QAASSDSAQG SDVSLTACK //