ID   A0A024R2F2_HUMAN        Unreviewed;       213 AA.
AC   A0A024R2F2;
DT   09-JUL-2014, integrated into UniProtKB/TrEMBL.
DT   09-JUL-2014, sequence version 1.
DT   10-MAY-2017, entry version 24.
DE   SubName: Full=von Hippel-Lindau tumor suppressor isoform 2 {ECO:0000313|EMBL:ALQ33845.1};
DE   SubName: Full=von Hippel-Lindau tumor suppressor, isoform CRA_a {ECO:0000313|EMBL:EAW64066.1};
GN   Name=VHL {ECO:0000313|EMBL:EAW64066.1};
GN   ORFNames=hCG_1994953 {ECO:0000313|EMBL:EAW64066.1};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|EMBL:EAW64066.1};
RN   [1] {ECO:0000313|EMBL:EAW64066.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=11181995; DOI=10.1126/science.1058040;
RA   Venter J.C., Adams M.D., Myers E.W., Li P.W., Mural R.J., Sutton G.G.,
RA   Smith H.O., Yandell M., Evans C.A., Holt R.A., Gocayne J.D.,
RA   Amanatides P., Ballew R.M., Huson D.H., Wortman J.R., Zhang Q.,
RA   Kodira C.D., Zheng X.H., Chen L., Skupski M., Subramanian G.,
RA   Thomas P.D., Zhang J., Gabor Miklos G.L., Nelson C., Broder S.,
RA   Clark A.G., Nadeau J., McKusick V.A., Zinder N., Levine A.J.,
RA   Roberts R.J., Simon M., Slayman C., Hunkapiller M., Bolanos R.,
RA   Delcher A., Dew I., Fasulo D., Flanigan M., Florea L., Halpern A.,
RA   Hannenhalli S., Kravitz S., Levy S., Mobarry C., Reinert K.,
RA   Remington K., Abu-Threideh J., Beasley E., Biddick K., Bonazzi V.,
RA   Brandon R., Cargill M., Chandramouliswaran I., Charlab R.,
RA   Chaturvedi K., Deng Z., Di Francesco V., Dunn P., Eilbeck K.,
RA   Evangelista C., Gabrielian A.E., Gan W., Ge W., Gong F., Gu Z.,
RA   Guan P., Heiman T.J., Higgins M.E., Ji R.R., Ke Z., Ketchum K.A.,
RA   Lai Z., Lei Y., Li Z., Li J., Liang Y., Lin X., Lu F., Merkulov G.V.,
RA   Milshina N., Moore H.M., Naik A.K., Narayan V.A., Neelam B.,
RA   Nusskern D., Rusch D.B., Salzberg S., Shao W., Shue B., Sun J.,
RA   Wang Z., Wang A., Wang X., Wang J., Wei M., Wides R., Xiao C., Yan C.,
RA   Yao A., Ye J., Zhan M., Zhang W., Zhang H., Zhao Q., Zheng L.,
RA   Zhong F., Zhong W., Zhu S., Zhao S., Gilbert D., Baumhueter S.,
RA   Spier G., Carter C., Cravchik A., Woodage T., Ali F., An H., Awe A.,
RA   Baldwin D., Baden H., Barnstead M., Barrow I., Beeson K., Busam D.,
RA   Carver A., Center A., Cheng M.L., Curry L., Danaher S., Davenport L.,
RA   Desilets R., Dietz S., Dodson K., Doup L., Ferriera S., Garg N.,
RA   Gluecksmann A., Hart B., Haynes J., Haynes C., Heiner C., Hladun S.,
RA   Hostin D., Houck J., Howland T., Ibegwam C., Johnson J., Kalush F.,
RA   Kline L., Koduru S., Love A., Mann F., May D., McCawley S.,
RA   McIntosh T., McMullen I., Moy M., Moy L., Murphy B., Nelson K.,
RA   Pfannkoch C., Pratts E., Puri V., Qureshi H., Reardon M.,
RA   Rodriguez R., Rogers Y.H., Romblad D., Ruhfel B., Scott R., Sitter C.,
RA   Smallwood M., Stewart E., Strong R., Suh E., Thomas R., Tint N.N.,
RA   Tse S., Vech C., Wang G., Wetter J., Williams S., Williams M.,
RA   Windsor S., Winn-Deen E., Wolfe K., Zaveri J., Zaveri K., Abril J.F.,
RA   Guigo R., Campbell M.J., Sjolander K.V., Karlak B., Kejariwal A.,
RA   Mi H., Lazareva B., Hatton T., Narechania A., Diemer K.,
RA   Muruganujan A., Guo N., Sato S., Bafna V., Istrail S., Lippert R.,
RA   Schwartz R., Walenz B., Yooseph S., Allen D., Basu A., Baxendale J.,
RA   Blick L., Caminha M., Carnes-Stine J., Caulk P., Chiang Y.H.,
RA   Coyne M., Dahlke C., Mays A., Dombroski M., Donnelly M., Ely D.,
RA   Esparham S., Fosler C., Gire H., Glanowski S., Glasser K., Glodek A.,
RA   Gorokhov M., Graham K., Gropman B., Harris M., Heil J., Henderson S.,
RA   Hoover J., Jennings D., Jordan C., Jordan J., Kasha J., Kagan L.,
RA   Kraft C., Levitsky A., Lewis M., Liu X., Lopez J., Ma D., Majoros W.,
RA   McDaniel J., Murphy S., Newman M., Nguyen T., Nguyen N., Nodell M.,
RA   Pan S., Peck J., Peterson M., Rowe W., Sanders R., Scott J.,
RA   Simpson M., Smith T., Sprague A., Stockwell T., Turner R., Venter E.,
RA   Wang M., Wen M., Wu D., Wu M., Xia A., Zandieh A., Zhu X.;
RT   "The sequence of the human genome.";
RL   Science 291:1304-1351(2001).
RN   [2] {ECO:0000313|EMBL:EAW64066.1}
RP   NUCLEOTIDE SEQUENCE.
RA   Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L.,
RA   Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
RA   Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
RA   Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
RA   Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
RA   Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
RA   Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
RA   Venter J.C.;
RL   Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000313|EMBL:ALQ33845.1}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=26871637; DOI=10.1016/j.cell.2016.01.029;
RA   Yang X., Coulombe-Huntington J., Kang S., Sheynkman G.M., Hao T.,
RA   Richardson A., Sun S., Yang F., Shen Y.A., Murray R., Spirohn K.,
RA   Begg B.E., Duran-Frigola M., MacWilliams A., Pevzner S.J., Zhong Q.,
RA   Trigg S.A., Tam S., Ghamsari L., Sahni N., Yi S., Rodriguez M.D.,
RA   Balcha D., Tan G., Costanzo M., Andrews B., Boone C., Zhou X.J.,
RA   Salehi-Ashtiani K., Charloteaux B., Chen A., Calderwood M.A., Aloy P.,
RA   Roth F.P., Hill D.E., Iakoucheva L.M., Xia Y., Vidal M.;
RT   "Widespread Expansion of Protein Interaction Capabilities by
RT   Alternative Splicing.";
RL   Cell 164:805-817(2016).
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DR   EMBL; KU178387; ALQ33845.1; -; mRNA.
DR   EMBL; CH471055; EAW64066.1; -; Genomic_DNA.
DR   RefSeq; NP_000542.1; NM_000551.3.
DR   RefSeq; NP_000542.1; NM_000551.3.
DR   RefSeq; NP_000542.1; NM_000551.3.
DR   UniGene; Hs.517792; -.
DR   STRING; 9606.ENSP00000256474; -.
DR   PaxDb; A0A024R2F2; -.
DR   GeneID; 7428; -.
DR   KEGG; hsa:7428; -.
DR   CTD; 7428; -.
DR   eggNOG; KOG4710; Eukaryota.
DR   eggNOG; ENOG4111PRU; LUCA.
DR   KO; K03871; -.
DR   OMA; GRRMTTY; -.
DR   OrthoDB; EOG091G0NHA; -.
DR   GenomeRNAi; 7428; -.
DR   GO; GO:0005654; C:nucleoplasm; IDA:HPA.
DR   CDD; cd05468; pVHL; 1.
DR   Gene3D; 1.10.750.10; -; 1.
DR   Gene3D; 2.60.40.780; -; 1.
DR   InterPro; IPR002714; VHL.
DR   InterPro; IPR024048; VHL_alpha_dom.
DR   InterPro; IPR024053; VHL_beta_dom.
DR   InterPro; IPR022772; VHL_tumour_suppress_b/a_dom.
DR   PANTHER; PTHR15160:SF10; PTHR15160:SF10; 1.
DR   Pfam; PF01847; VHL; 1.
DR   SUPFAM; SSF49468; SSF49468; 1.
PE   2: Evidence at transcript level;
FT   DOMAIN       63    143       VHL. {ECO:0000259|Pfam:PF01847}.
FT   NON_TER     213    213       {ECO:0000313|EMBL:ALQ33845.1}.
SQ   SEQUENCE   213 AA;  24153 MW;  BA5D6765FBC16EA7 CRC64;
     MPRRAENWDE AEVGAEEAGV EEYGPEEDGG EESGAEESGP EESGPEELGA EEEMEAGRPR
     PVLRSVNSRE PSQVIFCNRS PRVVLPVWLN FDGEPQPYPT LPPGTGRRIH SYRGHLWLFR
     DAGTHDGLLV NQTELFVPSL NVDGQPIFAN ITLPVYTLKE RCLQVVRSLV KPENYRRLDI
     VRSLYEDLED HPNVQKDLER LTQERIAHQR MGD
//