ID A0A024R1I3_HUMAN Unreviewed; 296 AA. AC A0A024R1I3; DT 09-JUL-2014, integrated into UniProtKB/TrEMBL. DT 09-JUL-2014, sequence version 1. DT 08-NOV-2023, entry version 64. DE SubName: Full=Pyridoxal (Pyridoxine, vitamin B6) phosphatase, isoform CRA_a {ECO:0000313|EMBL:EAW60176.1}; DE SubName: Full=Testicular secretory protein Li 36 {ECO:0000313|EMBL:AEE61173.1}; GN Name=PDXP {ECO:0000313|EMBL:EAW60176.1}; GN ORFNames=hCG_41847 {ECO:0000313|EMBL:EAW60176.1}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606 {ECO:0000313|EMBL:AEE61173.1}; RN [1] {ECO:0000313|EMBL:EAW60176.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=11181995; DOI=10.1126/science.1058040; RA Venter J.C., Adams M.D., Myers E.W., Li P.W., Mural R.J., Sutton G.G., RA Smith H.O., Yandell M., Evans C.A., Holt R.A., Gocayne J.D., Amanatides P., RA Ballew R.M., Huson D.H., Wortman J.R., Zhang Q., Kodira C.D., Zheng X.H., RA Chen L., Skupski M., Subramanian G., Thomas P.D., Zhang J., RA Gabor Miklos G.L., Nelson C., Broder S., Clark A.G., Nadeau J., RA McKusick V.A., Zinder N., Levine A.J., Roberts R.J., Simon M., Slayman C., RA Hunkapiller M., Bolanos R., Delcher A., Dew I., Fasulo D., Flanigan M., RA Florea L., Halpern A., Hannenhalli S., Kravitz S., Levy S., Mobarry C., RA Reinert K., Remington K., Abu-Threideh J., Beasley E., Biddick K., RA Bonazzi V., Brandon R., Cargill M., Chandramouliswaran I., Charlab R., RA Chaturvedi K., Deng Z., Di Francesco V., Dunn P., Eilbeck K., RA Evangelista C., Gabrielian A.E., Gan W., Ge W., Gong F., Gu Z., Guan P., RA Heiman T.J., Higgins M.E., Ji R.R., Ke Z., Ketchum K.A., Lai Z., Lei Y., RA Li Z., Li J., Liang Y., Lin X., Lu F., Merkulov G.V., Milshina N., RA Moore H.M., Naik A.K., Narayan V.A., Neelam B., Nusskern D., Rusch D.B., RA Salzberg S., Shao W., Shue B., Sun J., Wang Z., Wang A., Wang X., Wang J., RA Wei M., Wides R., Xiao C., Yan C., Yao A., Ye J., Zhan M., Zhang W., RA Zhang H., Zhao Q., Zheng L., Zhong F., Zhong W., Zhu S., Zhao S., RA Gilbert D., Baumhueter S., Spier G., Carter C., Cravchik A., Woodage T., RA Ali F., An H., Awe A., Baldwin D., Baden H., Barnstead M., Barrow I., RA Beeson K., Busam D., Carver A., Center A., Cheng M.L., Curry L., RA Danaher S., Davenport L., Desilets R., Dietz S., Dodson K., Doup L., RA Ferriera S., Garg N., Gluecksmann A., Hart B., Haynes J., Haynes C., RA Heiner C., Hladun S., Hostin D., Houck J., Howland T., Ibegwam C., RA Johnson J., Kalush F., Kline L., Koduru S., Love A., Mann F., May D., RA McCawley S., McIntosh T., McMullen I., Moy M., Moy L., Murphy B., RA Nelson K., Pfannkoch C., Pratts E., Puri V., Qureshi H., Reardon M., RA Rodriguez R., Rogers Y.H., Romblad D., Ruhfel B., Scott R., Sitter C., RA Smallwood M., Stewart E., Strong R., Suh E., Thomas R., Tint N.N., Tse S., RA Vech C., Wang G., Wetter J., Williams S., Williams M., Windsor S., RA Winn-Deen E., Wolfe K., Zaveri J., Zaveri K., Abril J.F., Guigo R., RA Campbell M.J., Sjolander K.V., Karlak B., Kejariwal A., Mi H., Lazareva B., RA Hatton T., Narechania A., Diemer K., Muruganujan A., Guo N., Sato S., RA Bafna V., Istrail S., Lippert R., Schwartz R., Walenz B., Yooseph S., RA Allen D., Basu A., Baxendale J., Blick L., Caminha M., Carnes-Stine J., RA Caulk P., Chiang Y.H., Coyne M., Dahlke C., Mays A., Dombroski M., RA Donnelly M., Ely D., Esparham S., Fosler C., Gire H., Glanowski S., RA Glasser K., Glodek A., Gorokhov M., Graham K., Gropman B., Harris M., RA Heil J., Henderson S., Hoover J., Jennings D., Jordan C., Jordan J., RA Kasha J., Kagan L., Kraft C., Levitsky A., Lewis M., Liu X., Lopez J., RA Ma D., Majoros W., McDaniel J., Murphy S., Newman M., Nguyen T., Nguyen N., RA Nodell M., Pan S., Peck J., Peterson M., Rowe W., Sanders R., Scott J., RA Simpson M., Smith T., Sprague A., Stockwell T., Turner R., Venter E., RA Wang M., Wen M., Wu D., Wu M., Xia A., Zandieh A., Zhu X.; RT "The sequence of the human genome."; RL Science 291:1304-1351(2001). RN [2] {ECO:0000313|EMBL:EAW60176.1} RP NUCLEOTIDE SEQUENCE. RA Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., Mobarry C.M., RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., RA Hunkapiller M.W., Myers E.W., Venter J.C.; RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases. RN [3] {ECO:0000313|EMBL:AEE61173.1} RP NUCLEOTIDE SEQUENCE. RA Li J.Y.; RT "Human testis protein."; RL Submitted (MAR-2010) to the EMBL/GenBank/DDBJ databases. CC -!- COFACTOR: CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420; CC Evidence={ECO:0000256|PIRSR:PIRSR000915-3}; CC Note=Divalent metal ions. Mg(2+) is the most effective. CC {ECO:0000256|PIRSR:PIRSR000915-3}; CC -!- SIMILARITY: Belongs to the HAD-like hydrolase superfamily. CC {ECO:0000256|PIRNR:PIRNR000915}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; HM005576; AEE61173.1; -; mRNA. DR EMBL; CH471095; EAW60176.1; -; Genomic_DNA. DR RefSeq; NP_064711.1; NM_020315.4. DR SMR; A0A024R1I3; -. DR Antibodypedia; 34919; 116 antibodies from 27 providers. DR DNASU; 57026; -. DR GeneID; 57026; -. DR KEGG; hsa:57026; -. DR CTD; 57026; -. DR VEuPathDB; HostDB:ENSG00000241360; -. DR HOGENOM; CLU_043473_0_1_1; -. DR OMA; MDGVLIH; -. DR OrthoDB; 217676at2759; -. DR BioGRID-ORCS; 57026; 10 hits in 1172 CRISPR screens. DR ChiTaRS; PDXP; human. DR GenomeRNAi; 57026; -. DR ExpressionAtlas; A0A024R1I3; baseline and differential. DR GO; GO:0005911; C:cell-cell junction; IEA:Ensembl. DR GO; GO:0000287; F:magnesium ion binding; IEA:Ensembl. DR GO; GO:0042803; F:protein homodimerization activity; IEA:Ensembl. DR GO; GO:0033883; F:pyridoxal phosphatase activity; IEA:Ensembl. DR GO; GO:0016311; P:dephosphorylation; IEA:Ensembl. DR GO; GO:0032361; P:pyridoxal phosphate catabolic process; IEA:Ensembl. DR CDD; cd07510; HAD_Pase_UmpH-like; 1. DR Gene3D; 3.40.50.1000; HAD superfamily/HAD-like; 2. DR InterPro; IPR036412; HAD-like_sf. DR InterPro; IPR006357; HAD-SF_hydro_IIA. DR InterPro; IPR023214; HAD_sf. DR InterPro; IPR006349; PGP_euk. DR NCBIfam; TIGR01460; HAD-SF-IIA; 1. DR NCBIfam; TIGR01452; PGP_euk; 1. DR PANTHER; PTHR19288; 4-NITROPHENYLPHOSPHATASE-RELATED; 1. DR PANTHER; PTHR19288:SF94; CHRONOPHIN; 1. DR Pfam; PF13344; Hydrolase_6; 1. DR Pfam; PF13242; Hydrolase_like; 1. DR PIRSF; PIRSF000915; PGP-type_phosphatase; 1. DR SFLD; SFLDG01139; C2.A:_Pyridoxal_Phosphate_Phos; 1. DR SFLD; SFLDS00003; Haloacid_Dehalogenase; 1. DR SUPFAM; SSF56784; HAD-like; 1. PE 2: Evidence at transcript level; KW Hydrolase {ECO:0000256|PIRNR:PIRNR000915}; KW Magnesium {ECO:0000256|PIRSR:PIRSR000915-3}; KW Metal-binding {ECO:0000256|PIRSR:PIRSR000915-3}. FT ACT_SITE 25 FT /note="Nucleophile" FT /evidence="ECO:0000256|PIRSR:PIRSR000915-1" FT ACT_SITE 27 FT /note="Proton donor" FT /evidence="ECO:0000256|PIRSR:PIRSR000915-1" FT BINDING 25 FT /ligand="Mg(2+)" FT /ligand_id="ChEBI:CHEBI:18420" FT /evidence="ECO:0000256|PIRSR:PIRSR000915-3" FT BINDING 27 FT /ligand="Mg(2+)" FT /ligand_id="ChEBI:CHEBI:18420" FT /evidence="ECO:0000256|PIRSR:PIRSR000915-3" FT BINDING 58..60 FT /ligand="substrate" FT /evidence="ECO:0000256|PIRSR:PIRSR000915-2" FT BINDING 182 FT /ligand="substrate" FT /evidence="ECO:0000256|PIRSR:PIRSR000915-2" FT BINDING 213 FT /ligand="substrate" FT /evidence="ECO:0000256|PIRSR:PIRSR000915-2" FT BINDING 238 FT /ligand="Mg(2+)" FT /ligand_id="ChEBI:CHEBI:18420" FT /evidence="ECO:0000256|PIRSR:PIRSR000915-3" SQ SEQUENCE 296 AA; 31698 MW; 33466C35A76B458C CRC64; MARCERLRGA ALRDVLGRAQ GVLFDCDGVL WNGERAVPGA PELLERLARA GKAALFVSNN SRRARPELAL RFARLGFGGL RAEQLFSSAL CAARLLRQRL PGPPDAPGAV FVLGGEGLRA ELRAAGLRLA GDPSAGDGAA PRVRAVLVGY DEHFSFAKLR EACAHLRDPE CLLVATDRDP WHPLSDGSRT PGTGSLAAAV ETASGRQALV VGKPSPYMFE CITENFSIDP ARTLMVGDRL ETDILFGHRC GMTTVLTLTG VSRLEEAQAY LAAGQHDLVP HYYVESIADL TEGLED //