ID A0A024CWI4_9INFA Unreviewed; 90 AA. AC A0A024CWI4; DT 09-JUL-2014, integrated into UniProtKB/TrEMBL. DT 09-JUL-2014, sequence version 1. DT 25-OCT-2017, entry version 19. DE RecName: Full=Protein PB1-F2 {ECO:0000256|SAAS:SAAS00347988}; GN Name=PB1-F2 {ECO:0000313|EMBL:AHZ39556.1}; OS Influenza A virus (A/black-headed gull/Georgia/9/2011(H13N8)). OC Viruses; ssRNA viruses; ssRNA negative-strand viruses; OC Orthomyxoviridae; Influenzavirus A. OX NCBI_TaxID=1478253 {ECO:0000313|EMBL:AHZ39556.1, ECO:0000313|Proteomes:UP000133131}; RN [1] {ECO:0000313|EMBL:AHZ39556.1, ECO:0000313|Proteomes:UP000133131} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=A/black-headed gull/Republic of Georgia/9/2011 RC {ECO:0000313|EMBL:AHZ39556.1}; RG The NIAID Influenza Genome Sequencing Consortium; RL Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|EMBL:AHZ39556.1, ECO:0000313|Proteomes:UP000133131} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=A/black-headed gull/Republic of Georgia/9/2011 RC {ECO:0000313|EMBL:AHZ39556.1}; RA Wentworth D.E., Halpin R.A., Lin X., Simenauer A., Akopov A., RA Mohan M., Fedorova N., Tsitrin T., Puri V., Stockwell T., Amedeo P., RA Bishop B., Gupta N., Hoover J., Katzel D., Schobel S., Shrivastava S., RA Thovarai V., Bao Y., Sanders R., Zhdanov S., Kiryutin B., Lipman D.J., RA Tatusova T., Fouchier R.A.M.; RT "The NIAID Influenza Genome Sequencing Project."; RL Submitted (MAY-2014) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Plays an important role in promoting lung pathology in CC both primary viral infection and secondary bacterial infection. CC Promotes alteration of mitochondrial morphology, dissipation of CC mitochondrial membrane potential, and cell death. Alternatively, CC inhibits the production of interferon in the infected cell at the CC level of host mitochondrial antiviral signaling MAVS. Its level of CC expression differs greatly depending on which cell type is CC infected, in a manner that is independent of the levels of CC expression of other viral proteins. Monocytic cells are more CC affected than epithelial cells. Seems to disable virus-infected CC monocytes or other host innate immune cells. During early stage of CC infection, predisposes the mitochondria to permeability transition CC through interaction with host SLC25A6/ANT3 and VDAC1. These CC proteins participate in the formation of the permeability CC transition pore complex (PTPC) responsible of the release of CC mitochondrial products that triggers apoptosis. CC {ECO:0000256|SAAS:SAAS00822166}. CC -!- SUBUNIT: Oligomer. Interacts with human SLC25A6/ANT3 and VDAC1. CC Interacts with host MAVS. {ECO:0000256|SAAS:SAAS00822162}. CC -!- SUBCELLULAR LOCATION: Host cytoplasm, host cytosol CC {ECO:0000256|SAAS:SAAS00542543}. CC -!- SUBCELLULAR LOCATION: Host mitochondrion inner membrane CC {ECO:0000256|SAAS:SAAS00822158}. CC -!- SUBCELLULAR LOCATION: Host nucleus CC {ECO:0000256|SAAS:SAAS00542458}. CC -!- SIMILARITY: Belongs to the influenza viruses PB1-F2 family. CC {ECO:0000256|SAAS:SAAS00542629}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; CY185663; AHZ39556.1; -; Viral_cRNA. DR Proteomes; UP000133131; Genome. DR GO; GO:0044164; C:host cell cytosol; IEA:UniProtKB-SubCell. DR GO; GO:0044192; C:host cell mitochondrial inner membrane; IEA:UniProtKB-SubCell. DR GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell. DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW. DR GO; GO:0039526; P:modulation by virus of host apoptotic process; IEA:UniProtKB-KW. DR GO; GO:0039545; P:suppression by virus of host MAVS activity; IEA:UniProtKB-KW. DR InterPro; IPR021045; Flu_proapoptotic_PB1-F2. DR Pfam; PF11986; PB1-F2; 1. PE 3: Inferred from homology; KW Apoptosis {ECO:0000256|SAAS:SAAS00822169}; KW Complete proteome {ECO:0000313|Proteomes:UP000133131}; KW Host cytoplasm {ECO:0000256|SAAS:SAAS00020173}; KW Host membrane {ECO:0000256|SAAS:SAAS00822165}; KW Host mitochondrion {ECO:0000256|SAAS:SAAS00822161}; KW Host mitochondrion inner membrane {ECO:0000256|SAAS:SAAS00822160}; KW Host nucleus {ECO:0000256|SAAS:SAAS00020027}; KW Host-virus interaction {ECO:0000256|SAAS:SAAS00822148}; KW Inhibition of host innate immune response by virus KW {ECO:0000256|SAAS:SAAS00822151}; KW Inhibition of host MAVS by virus {ECO:0000256|SAAS:SAAS00822153}; KW Inhibition of host RLR pathway by virus KW {ECO:0000256|SAAS:SAAS00822156}; KW Membrane {ECO:0000256|SAAS:SAAS00822147}; KW Modulation of host cell apoptosis by virus KW {ECO:0000256|SAAS:SAAS00822155}; KW Viral immunoevasion {ECO:0000256|SAAS:SAAS00822156}. FT DOMAIN 1 87 PB1-F2. {ECO:0000259|Pfam:PF11986}. SQ SEQUENCE 90 AA; 10911 MW; CDAEC6982B8AEAC5 CRC64; MEQEQDIPWT QSTEHTSTQK KGHGQQTPKL EHLSLTRSMD HYRRTMSQAD MHKRIVYWRP WLSLKNPTQG SLRTHVLKRW KLFSKHEWTS //