ID   A0A024CFA7_9REOV        Unreviewed;       775 AA.
AC   A0A024CFA7;
DT   09-JUL-2014, integrated into UniProtKB/TrEMBL.
DT   09-JUL-2014, sequence version 1.
DT   07-JAN-2015, entry version 5.
DE   RecName: Full=Outer capsid protein VP4 {ECO:0000256|RuleBase:RU004344, ECO:0000256|SAAS:SAAS00136896};
GN   Name=VP4 {ECO:0000313|EMBL:AHZ33086.1};
GN   ORFNames=L312_46656gpVP4 {ECO:0000313|EMBL:AHZ33086.1};
OS   Rotavirus A.
OC   Viruses; dsRNA viruses; Reoviridae; Sedoreovirinae; Rotavirus.
OX   NCBI_TaxID=28875 {ECO:0000313|EMBL:AHZ33086.1};
RN   [1] {ECO:0000313|EMBL:AHZ33086.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=RVA/Human-wt/ZAF/MRC-DPRU1052/2008/G1P[8]
RC   {ECO:0000313|EMBL:AHZ33086.1};
RA   Wentworth D.E., Halpin R.A., Stucker K.M., Akopov A., Fedorova N.,
RA   Tsitrin T., Puri V., Stockwell T., Amedeo P., Bishop B., Gupta N.,
RA   Hoover J., Katzel D., Schobel S., Shrivastava S., Nyaga M.M.,
RA   Magagula N.B., Peenze I., Seheri M.L., Mphahlele J., Steele A.D.,
RA   Mwenda M.J.;
RL   Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Outer capsid protein VP5*: forms the spike "foot" and
CC       "body". Acts as a membrane permeabilization protein that mediates
CC       release of viral particles from endosomal compartments into the
CC       cytoplasm. In integrin-dependent strains, VP5* targets the
CC       integrin heterodimer ITGA2/ITGB1 for cell attachment.
CC       {ECO:0000256|SAAS:SAAS00136874}.
CC   -!- FUNCTION: VP8* forms the head of the spikes. It is the viral
CC       hemagglutinin and an important target of neutralizing antibodies.
CC       In sialic acid-dependent strains, VP8* binds to host cell sialic
CC       acid, most probably a ganglioside, providing the initial contact.
CC       {ECO:0000256|SAAS:SAAS00136880}.
CC   -!- SUBCELLULAR LOCATION: Virion {ECO:0000256|RuleBase:RU004344,
CC       ECO:0000256|SAAS:SAAS00136899}.
CC   -!- SUBCELLULAR LOCATION: Virion {ECO:0000256|SAAS:SAAS00136883}. Host
CC       rough endoplasmic reticulum {ECO:0000256|SAAS:SAAS00136883}.
CC   -!- SIMILARITY: Belongs to the rotavirus VP4 family.
CC       {ECO:0000256|RuleBase:RU004344}.
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DR   EMBL; KJ752276; AHZ33086.1; -; Genomic_RNA.
DR   GO; GO:0044168; C:host cell rough endoplasmic reticulum; IEA:UniProtKB-SubCell.
DR   GO; GO:0039624; C:viral outer capsid; IEA:UniProtKB-KW.
DR   GO; GO:0039665; P:permeabilization of host organelle membrane involved in viral entry into host cell; IEA:UniProtKB-KW.
DR   GO; GO:0019062; P:virion attachment to host cell; IEA:UniProtKB-KW.
DR   Gene3D; 2.60.120.200; -; 1.
DR   InterPro; IPR013320; ConA-like_dom.
DR   InterPro; IPR000416; Haemagglutinin_VP4.
DR   Pfam; PF00426; VP4_haemagglut; 1.
DR   SUPFAM; SSF49899; SSF49899; 1.
PE   3: Inferred from homology;
KW   Capsid protein {ECO:0000256|RuleBase:RU004344,
KW   ECO:0000256|SAAS:SAAS00136875};
KW   Coiled coil {ECO:0000256|SAAS:SAAS00136856};
KW   Disulfide bond {ECO:0000256|SAAS:SAAS00136872};
KW   Hemagglutinin {ECO:0000256|SAAS:SAAS00136892};
KW   Host endoplasmic reticulum {ECO:0000256|SAAS:SAAS00136897};
KW   Host-virus interaction {ECO:0000256|SAAS:SAAS00136889};
KW   Outer capsid protein {ECO:0000256|SAAS:SAAS00136895};
KW   Viral attachment to host cell {ECO:0000256|SAAS:SAAS00136898};
KW   Viral penetration into host cytoplasm {ECO:0000256|SAAS:SAAS00136873};
KW   Viral penetration via permeabilization of host membrane
KW   {ECO:0000256|SAAS:SAAS00136865};
KW   Virion {ECO:0000256|RuleBase:RU004344, ECO:0000256|SAAS:SAAS00136893};
KW   Virus entry into host cell {ECO:0000256|SAAS:SAAS00136900}.
SQ   SEQUENCE   775 AA;  87409 MW;  DCB7BF9CC9639466 CRC64;
     MASLIYRQLL TNSYSVDLYD EIKQIGSEKT QNVTVNPGPF AQTRYAPVNW GHGEINDSTT
     VEPILDGPYQ PTTFTPPTDY WILINSNTNG VVYESTNNSD FWTAVIAVEP HVNPVDRQYN
     VFGENKQFNV RNDSDKWKFL EMFRGSSQND FYNRRTLTSD TRLVGILKYG GRIWTFHGET
     PRATTDSSST ANLNGISITI HSEFYIIPRS QESKCNEYIN NGLPPIQNTR NVVPLSLSSR
     SIQYTRAQVN EDITISKTSL WKEMQYNRDI IIRFKFGNSI IKLGGLGYKW SEISYKAANY
     QYNYLRDGEQ VTAHTTCSVN GVNNFSYNGG SLPTDFSISR YEVIKENSYV YVDYWDDSKA
     FRNMVYVRSL AANLNSVKCT GGSYDFSIPV GAWPVMNGGA VSLHFAGVTL STQFTDFVSL
     NSLRFRFSLT VDEPSFSILR TRTVNLYGLP AANPNNGNEY YEISGRFSLI SLVPTNDDYQ
     TPIMNSVTVR QDLERQLTDL REEFNSLSQE IAMSQLIDLA LLPLDMFSMF SGIKSTIDLT
     KSMATSVMKK FRKSKLATSV SEMTNSLSDA ASSASRSVSV RSNVSAFSNW TNVSNDVSNV
     TNSVNDISTQ TSTISKNLRL KEMITQTEGM SFDDISAAVL KTKIDMSTQI GKNTLPDIVT
     EASEKFIPKR SYRILKDDEV MEINTEGKFF AYKIDTLNEV PFDVNKFAEL VTNSPVISAI
     IDFKTLKNLN DNYGITRIEA LNLIKSNPNV LRNFINQNNP IIRNRIEQLI LQCKL
//