ID A0A024CFA7_9REOV Unreviewed; 775 AA. AC A0A024CFA7; DT 09-JUL-2014, integrated into UniProtKB/TrEMBL. DT 09-JUL-2014, sequence version 1. DT 20-JUN-2018, entry version 26. DE RecName: Full=Outer capsid protein VP4 {ECO:0000256|SAAS:SAAS00976480}; GN Name=VP4 {ECO:0000313|EMBL:AHZ33086.1}; GN ORFNames=L312_46656gpVP4 {ECO:0000313|EMBL:AHZ33086.1}; OS Rotavirus A. OC Viruses; dsRNA viruses; Reoviridae; Sedoreovirinae; Rotavirus. OX NCBI_TaxID=28875 {ECO:0000313|EMBL:AHZ33086.1, ECO:0000313|Proteomes:UP000155231}; RN [1] {ECO:0000313|EMBL:AHZ33086.1, ECO:0000313|Proteomes:UP000155231} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=RVA/Human-wt/ZAF/MRC-DPRU1052/2008/G1P[8] RC {ECO:0000313|EMBL:AHZ33086.1}; RA Wentworth D.E., Halpin R.A., Stucker K.M., Akopov A., Fedorova N., RA Tsitrin T., Puri V., Stockwell T., Amedeo P., Bishop B., Gupta N., RA Hoover J., Katzel D., Schobel S., Shrivastava S., Nyaga M.M., RA Magagula N.B., Peenze I., Seheri M.L., Mphahlele J., Steele A.D., RA Mwenda M.J.; RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Outer capsid protein VP5*: Forms the spike "foot" and CC "body" and acts as a membrane permeabilization protein that CC mediates release of viral particles from endosomal compartments CC into the cytoplasm. During entry, the part of VP5* that protrudes CC from the virus folds back on itself and reorganizes from a local CC dimer to a trimer. This reorganization may be linked to membrane CC penetration by exposing VP5* hydrophobic region. In integrin- CC dependent strains, VP5* targets the integrin heterodimer CC ITGA2/ITGB1 for cell attachment. {ECO:0000256|SAAS:SAAS01043052}. CC -!- SUBCELLULAR LOCATION: Host cell membrane CC {ECO:0000256|SAAS:SAAS01043051}. Host cytoplasm, host cytoskeleton CC {ECO:0000256|SAAS:SAAS01043062}. Host endoplasmic reticulum-Golgi CC intermediate compartment {ECO:0000256|SAAS:SAAS01043056}. Host CC rough endoplasmic reticulum {ECO:0000256|SAAS:SAAS00976475}. CC Virion {ECO:0000256|SAAS:SAAS00976484}. CC -!- SIMILARITY: Belongs to the rotavirus VP4 family. CC {ECO:0000256|SAAS:SAAS00976467}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; KJ752276; AHZ33086.1; -; Genomic_RNA. DR Proteomes; UP000155231; Genome. DR GO; GO:0044168; C:host cell rough endoplasmic reticulum; IEA:UniProtKB-SubCell. DR GO; GO:0039624; C:viral outer capsid; IEA:UniProtKB-KW. DR GO; GO:0039665; P:permeabilization of host organelle membrane involved in viral entry into host cell; IEA:UniProtKB-KW. DR GO; GO:0099008; P:viral entry via permeabilization of inner membrane; IEA:UniProtKB-KW. DR GO; GO:0019062; P:virion attachment to host cell; IEA:UniProtKB-KW. DR InterPro; IPR013320; ConA-like_dom_sf. DR InterPro; IPR035330; Rota_VP4_MID. DR InterPro; IPR038017; Rota_VP4_MID_sf. DR InterPro; IPR035329; VP4_helical. DR Pfam; PF17477; Rota_VP4_MID; 1. DR Pfam; PF17478; VP4_helical; 1. DR SUPFAM; SSF111379; SSF111379; 1. DR SUPFAM; SSF49899; SSF49899; 1. PE 3: Inferred from homology; KW Capsid protein {ECO:0000256|SAAS:SAAS00976486}; KW Coiled coil {ECO:0000256|SAAS:SAAS00976466, ECO:0000256|SAM:Coils}; KW Complete proteome {ECO:0000313|Proteomes:UP000155231}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00976472}; KW Hemagglutinin {ECO:0000256|SAAS:SAAS00976470}; KW Host cell membrane {ECO:0000256|SAAS:SAAS01043055}; KW Host cytoplasm {ECO:0000256|SAAS:SAAS01043067}; KW Host cytoskeleton {ECO:0000256|SAAS:SAAS01043063}; KW Host endoplasmic reticulum {ECO:0000256|SAAS:SAAS00976461}; KW Host membrane {ECO:0000256|SAAS:SAAS01043066}; KW Host-virus interaction {ECO:0000256|SAAS:SAAS00976471}; KW Membrane {ECO:0000256|SAAS:SAAS01043057}; KW Outer capsid protein {ECO:0000256|SAAS:SAAS00976478}; KW Viral attachment to host cell {ECO:0000256|SAAS:SAAS00976481}; KW Viral penetration into host cytoplasm {ECO:0000256|SAAS:SAAS00976479}; KW Viral penetration via permeabilization of host membrane KW {ECO:0000256|SAAS:SAAS00976462}; KW Virion {ECO:0000256|SAAS:SAAS00976459}; KW Virus entry into host cell {ECO:0000256|SAAS:SAAS00976477}. FT DOMAIN 249 473 Rota_VP4_MID. {ECO:0000259|Pfam:PF17477}. FT DOMAIN 485 775 VP4_helical. {ECO:0000259|Pfam:PF17478}. FT COILED 483 510 {ECO:0000256|SAM:Coils}. SQ SEQUENCE 775 AA; 87409 MW; DCB7BF9CC9639466 CRC64; MASLIYRQLL TNSYSVDLYD EIKQIGSEKT QNVTVNPGPF AQTRYAPVNW GHGEINDSTT VEPILDGPYQ PTTFTPPTDY WILINSNTNG VVYESTNNSD FWTAVIAVEP HVNPVDRQYN VFGENKQFNV RNDSDKWKFL EMFRGSSQND FYNRRTLTSD TRLVGILKYG GRIWTFHGET PRATTDSSST ANLNGISITI HSEFYIIPRS QESKCNEYIN NGLPPIQNTR NVVPLSLSSR SIQYTRAQVN EDITISKTSL WKEMQYNRDI IIRFKFGNSI IKLGGLGYKW SEISYKAANY QYNYLRDGEQ VTAHTTCSVN GVNNFSYNGG SLPTDFSISR YEVIKENSYV YVDYWDDSKA FRNMVYVRSL AANLNSVKCT GGSYDFSIPV GAWPVMNGGA VSLHFAGVTL STQFTDFVSL NSLRFRFSLT VDEPSFSILR TRTVNLYGLP AANPNNGNEY YEISGRFSLI SLVPTNDDYQ TPIMNSVTVR QDLERQLTDL REEFNSLSQE IAMSQLIDLA LLPLDMFSMF SGIKSTIDLT KSMATSVMKK FRKSKLATSV SEMTNSLSDA ASSASRSVSV RSNVSAFSNW TNVSNDVSNV TNSVNDISTQ TSTISKNLRL KEMITQTEGM SFDDISAAVL KTKIDMSTQI GKNTLPDIVT EASEKFIPKR SYRILKDDEV MEINTEGKFF AYKIDTLNEV PFDVNKFAEL VTNSPVISAI IDFKTLKNLN DNYGITRIEA LNLIKSNPNV LRNFINQNNP IIRNRIEQLI LQCKL //