ID   A0A024CFA7_9REOV        Unreviewed;       775 AA.
AC   A0A024CFA7;
DT   09-JUL-2014, integrated into UniProtKB/TrEMBL.
DT   09-JUL-2014, sequence version 1.
DT   20-JUN-2018, entry version 26.
DE   RecName: Full=Outer capsid protein VP4 {ECO:0000256|SAAS:SAAS00976480};
GN   Name=VP4 {ECO:0000313|EMBL:AHZ33086.1};
GN   ORFNames=L312_46656gpVP4 {ECO:0000313|EMBL:AHZ33086.1};
OS   Rotavirus A.
OC   Viruses; dsRNA viruses; Reoviridae; Sedoreovirinae; Rotavirus.
OX   NCBI_TaxID=28875 {ECO:0000313|EMBL:AHZ33086.1, ECO:0000313|Proteomes:UP000155231};
RN   [1] {ECO:0000313|EMBL:AHZ33086.1, ECO:0000313|Proteomes:UP000155231}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=RVA/Human-wt/ZAF/MRC-DPRU1052/2008/G1P[8]
RC   {ECO:0000313|EMBL:AHZ33086.1};
RA   Wentworth D.E., Halpin R.A., Stucker K.M., Akopov A., Fedorova N.,
RA   Tsitrin T., Puri V., Stockwell T., Amedeo P., Bishop B., Gupta N.,
RA   Hoover J., Katzel D., Schobel S., Shrivastava S., Nyaga M.M.,
RA   Magagula N.B., Peenze I., Seheri M.L., Mphahlele J., Steele A.D.,
RA   Mwenda M.J.;
RL   Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Outer capsid protein VP5*: Forms the spike "foot" and
CC       "body" and acts as a membrane permeabilization protein that
CC       mediates release of viral particles from endosomal compartments
CC       into the cytoplasm. During entry, the part of VP5* that protrudes
CC       from the virus folds back on itself and reorganizes from a local
CC       dimer to a trimer. This reorganization may be linked to membrane
CC       penetration by exposing VP5* hydrophobic region. In integrin-
CC       dependent strains, VP5* targets the integrin heterodimer
CC       ITGA2/ITGB1 for cell attachment. {ECO:0000256|SAAS:SAAS01043052}.
CC   -!- SUBCELLULAR LOCATION: Host cell membrane
CC       {ECO:0000256|SAAS:SAAS01043051}. Host cytoplasm, host cytoskeleton
CC       {ECO:0000256|SAAS:SAAS01043062}. Host endoplasmic reticulum-Golgi
CC       intermediate compartment {ECO:0000256|SAAS:SAAS01043056}. Host
CC       rough endoplasmic reticulum {ECO:0000256|SAAS:SAAS00976475}.
CC       Virion {ECO:0000256|SAAS:SAAS00976484}.
CC   -!- SIMILARITY: Belongs to the rotavirus VP4 family.
CC       {ECO:0000256|SAAS:SAAS00976467}.
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DR   EMBL; KJ752276; AHZ33086.1; -; Genomic_RNA.
DR   Proteomes; UP000155231; Genome.
DR   GO; GO:0044168; C:host cell rough endoplasmic reticulum; IEA:UniProtKB-SubCell.
DR   GO; GO:0039624; C:viral outer capsid; IEA:UniProtKB-KW.
DR   GO; GO:0039665; P:permeabilization of host organelle membrane involved in viral entry into host cell; IEA:UniProtKB-KW.
DR   GO; GO:0099008; P:viral entry via permeabilization of inner membrane; IEA:UniProtKB-KW.
DR   GO; GO:0019062; P:virion attachment to host cell; IEA:UniProtKB-KW.
DR   InterPro; IPR013320; ConA-like_dom_sf.
DR   InterPro; IPR035330; Rota_VP4_MID.
DR   InterPro; IPR038017; Rota_VP4_MID_sf.
DR   InterPro; IPR035329; VP4_helical.
DR   Pfam; PF17477; Rota_VP4_MID; 1.
DR   Pfam; PF17478; VP4_helical; 1.
DR   SUPFAM; SSF111379; SSF111379; 1.
DR   SUPFAM; SSF49899; SSF49899; 1.
PE   3: Inferred from homology;
KW   Capsid protein {ECO:0000256|SAAS:SAAS00976486};
KW   Coiled coil {ECO:0000256|SAAS:SAAS00976466, ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000155231};
KW   Disulfide bond {ECO:0000256|SAAS:SAAS00976472};
KW   Hemagglutinin {ECO:0000256|SAAS:SAAS00976470};
KW   Host cell membrane {ECO:0000256|SAAS:SAAS01043055};
KW   Host cytoplasm {ECO:0000256|SAAS:SAAS01043067};
KW   Host cytoskeleton {ECO:0000256|SAAS:SAAS01043063};
KW   Host endoplasmic reticulum {ECO:0000256|SAAS:SAAS00976461};
KW   Host membrane {ECO:0000256|SAAS:SAAS01043066};
KW   Host-virus interaction {ECO:0000256|SAAS:SAAS00976471};
KW   Membrane {ECO:0000256|SAAS:SAAS01043057};
KW   Outer capsid protein {ECO:0000256|SAAS:SAAS00976478};
KW   Viral attachment to host cell {ECO:0000256|SAAS:SAAS00976481};
KW   Viral penetration into host cytoplasm {ECO:0000256|SAAS:SAAS00976479};
KW   Viral penetration via permeabilization of host membrane
KW   {ECO:0000256|SAAS:SAAS00976462};
KW   Virion {ECO:0000256|SAAS:SAAS00976459};
KW   Virus entry into host cell {ECO:0000256|SAAS:SAAS00976477}.
FT   DOMAIN      249    473       Rota_VP4_MID. {ECO:0000259|Pfam:PF17477}.
FT   DOMAIN      485    775       VP4_helical. {ECO:0000259|Pfam:PF17478}.
FT   COILED      483    510       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   775 AA;  87409 MW;  DCB7BF9CC9639466 CRC64;
     MASLIYRQLL TNSYSVDLYD EIKQIGSEKT QNVTVNPGPF AQTRYAPVNW GHGEINDSTT
     VEPILDGPYQ PTTFTPPTDY WILINSNTNG VVYESTNNSD FWTAVIAVEP HVNPVDRQYN
     VFGENKQFNV RNDSDKWKFL EMFRGSSQND FYNRRTLTSD TRLVGILKYG GRIWTFHGET
     PRATTDSSST ANLNGISITI HSEFYIIPRS QESKCNEYIN NGLPPIQNTR NVVPLSLSSR
     SIQYTRAQVN EDITISKTSL WKEMQYNRDI IIRFKFGNSI IKLGGLGYKW SEISYKAANY
     QYNYLRDGEQ VTAHTTCSVN GVNNFSYNGG SLPTDFSISR YEVIKENSYV YVDYWDDSKA
     FRNMVYVRSL AANLNSVKCT GGSYDFSIPV GAWPVMNGGA VSLHFAGVTL STQFTDFVSL
     NSLRFRFSLT VDEPSFSILR TRTVNLYGLP AANPNNGNEY YEISGRFSLI SLVPTNDDYQ
     TPIMNSVTVR QDLERQLTDL REEFNSLSQE IAMSQLIDLA LLPLDMFSMF SGIKSTIDLT
     KSMATSVMKK FRKSKLATSV SEMTNSLSDA ASSASRSVSV RSNVSAFSNW TNVSNDVSNV
     TNSVNDISTQ TSTISKNLRL KEMITQTEGM SFDDISAAVL KTKIDMSTQI GKNTLPDIVT
     EASEKFIPKR SYRILKDDEV MEINTEGKFF AYKIDTLNEV PFDVNKFAEL VTNSPVISAI
     IDFKTLKNLN DNYGITRIEA LNLIKSNPNV LRNFINQNNP IIRNRIEQLI LQCKL
//