ID A0A023H864_9INFA Unreviewed; 759 AA. AC A0A023H864; DT 09-JUL-2014, integrated into UniProtKB/TrEMBL. DT 09-JUL-2014, sequence version 1. DT 15-MAR-2017, entry version 16. DE RecName: Full=Polymerase basic protein 2 {ECO:0000256|RuleBase:RU361246, ECO:0000256|SAAS:SAAS00399408}; GN Name=PB2 {ECO:0000256|RuleBase:RU361246, ECO:0000313|EMBL:AGG53297.1}; OS Influenza A virus (A/Northern shoveler/Korea/SD175/2008(H7N3)). OC Viruses; ssRNA viruses; ssRNA negative-strand viruses; OC Orthomyxoviridae; Influenzavirus A. OX NCBI_TaxID=1293832 {ECO:0000313|EMBL:AGG53297.1}; RN [1] {ECO:0000313|EMBL:AGG53297.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=A/Northern shoveler/Korea/SD175/2008 RC {ECO:0000313|EMBL:AGG53297.1}; RA Kang H.-M., Park H.-Y., Lee K.-J., Choi J.-G., Lee E.-K., Song B.-M., RA Lee H.-S., Lee Y.-J.; RT "Ecology of H7 avian influenza viruses in wild birds in South Korea RT and their genetic comparison with novel H7N9 viruses circulating in RT China."; RL Submitted (FEB-2013) to the EMBL/GenBank/DDBJ databases. CC -!- SUBUNIT: Influenza RNA polymerase is composed of three subunits: CC PB1, PB2 and PA. Interacts (via N-terminus) with PB1 (via C- CC terminus). Interacts with nucleoprotein NP (via N-terminus). CC Interacts (via N-terminus) with host MAVS (via N-terminus); this CC interaction inhibits host innate immune response. CC {ECO:0000256|SAAS:SAAS00399379}. CC -!- SUBCELLULAR LOCATION: Virion {ECO:0000256|RuleBase:RU361246}. Host CC nucleus {ECO:0000256|RuleBase:RU361246}. Host mitochondrion CC {ECO:0000256|RuleBase:RU361246}. CC -!- SIMILARITY: Belongs to the influenza viruses PB2 family. CC {ECO:0000256|RuleBase:RU361246, ECO:0000256|SAAS:SAAS00584119}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; KC609820; AGG53297.1; -; Viral_cRNA. DR GO; GO:0033650; C:host cell mitochondrion; IEA:UniProtKB-SubCell. DR GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell. DR GO; GO:0019012; C:virion; IEA:UniProtKB-SubCell. DR GO; GO:0003723; F:RNA binding; IEA:InterPro. DR GO; GO:0003968; F:RNA-directed 5'-3' RNA polymerase activity; IEA:InterPro. DR GO; GO:0006370; P:7-methylguanosine mRNA capping; IEA:UniProtKB-KW. DR GO; GO:0075526; P:cap snatching; IEA:UniProtKB-KW. DR GO; GO:0039545; P:suppression by virus of host MAVS activity; IEA:UniProtKB-KW. DR GO; GO:0039523; P:suppression by virus of host RNA polymerase II activity; IEA:UniProtKB-KW. DR GO; GO:0006351; P:transcription, DNA-templated; IEA:InterPro. DR InterPro; IPR001591; RNA_pol_PB2_orthomyxovir. DR Pfam; PF00604; Flu_PB2; 1. DR ProDom; PD001667; RNA_pol_PB2_orthomyxovir; 1. PE 3: Inferred from homology; KW Cap snatching {ECO:0000256|SAAS:SAAS00118359}; KW Eukaryotic host gene expression shutoff by virus KW {ECO:0000256|SAAS:SAAS00118356}; KW Eukaryotic host transcription shutoff by virus KW {ECO:0000256|SAAS:SAAS00118362}; KW Host gene expression shutoff by virus {ECO:0000256|SAAS:SAAS00118346}; KW Host mitochondrion {ECO:0000256|RuleBase:RU361246}; KW Host nucleus {ECO:0000256|RuleBase:RU361246}; KW Host-virus interaction {ECO:0000256|SAAS:SAAS00118344}; KW Inhibition of host innate immune response by virus KW {ECO:0000256|SAAS:SAAS00477452}; KW Inhibition of host MAVS by virus {ECO:0000256|SAAS:SAAS00477114}; KW Inhibition of host RLR pathway by virus KW {ECO:0000256|SAAS:SAAS00477196}; KW Inhibition of host RNA polymerase II by virus KW {ECO:0000256|SAAS:SAAS00118350}; KW mRNA capping {ECO:0000256|RuleBase:RU361246, KW ECO:0000256|SAAS:SAAS00118427}; KW mRNA processing {ECO:0000256|RuleBase:RU361246, KW ECO:0000256|SAAS:SAAS00118361}; KW Viral immunoevasion {ECO:0000256|SAAS:SAAS00477196}; KW Viral transcription {ECO:0000256|SAAS:SAAS00477398}; KW Virion {ECO:0000256|RuleBase:RU361246}. SQ SEQUENCE 759 AA; 85824 MW; AEC83E9079071577 CRC64; MERIKELRDL MSQSRTREIL TKTTVDHMAI IKKYTSGRQE KNPALRMKWM MAMKYPITAD KRIMEMIPER NEQGQTLWSK TNDAGSDRVM VSPLAVTWWN RNGPTTSTVH YPKVYKTYFE KVERLKHGTF GPVHFRNQVK IRRRVDINPG HADLSAKEAQ DVIMEVVFPN EVGARILTSE SQLTITKEKK EELQDCKIAP LMVAYMLERE LVRKTRFLPV AGGTSSVYIE VLHLTQGTCW EQMYTPGGEV RNDDVDQSLI IAARNIVRRA TVSADPLASL LEMCHSTQIG GIRMVDILRQ NPTEEQAVDI CKAAMGLRIS SSFSFGGFTF KRTSGSSVKK EEEVLTGNLQ TLKIRVHEGY EEFTMVGRRA TAILRKATRR LIQLIVSGKD EQSIAEAIIV AMVFSQEDCM IKAVRGDLNF VNRANQRLNP MHQLLRHFQK DAKVLFQNWG IEPIDNVMGM IGILPDMTPS TEMSLRGVRV SKMGVDEYSS TERVVVSIDR FLRVRDQRGN VLLSPEEVSE TQGTEKLTIT YSSSMMWEIN GPESVLVNTY QWIIRNWETV KIQWSQDPTM LYNKMEFEPF QSLVPKAARG QYSGFVRTLF QQMRDVLGTF DTAQIIKLLP FAAAPPEQSR MQFSSLTVNV RGSGMRILVR GNSPVFNYNK ATKRLTVLGK DAGALTEDPD EGTAGVESAV LRGFLILGKE DKRYGPALSI NELSNLAKGE KANVLIGQGD VVLVMKRKRD SSILTDSQTA TKRIRMAIN //