ID A0A022WB80_TRIRU Unreviewed; 652 AA. AC A0A022WB80; DT 11-JUN-2014, integrated into UniProtKB/TrEMBL. DT 11-JUN-2014, sequence version 1. DT 07-APR-2021, entry version 20. DE RecName: Full=Nuclear protein localization protein 4 {ECO:0000256|ARBA:ARBA00019709}; GN ORFNames=H103_02041 {ECO:0000313|EMBL:EZF55411.1}; OS Trichophyton rubrum CBS 288.86. OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes; OC Eurotiomycetidae; Onygenales; Arthrodermataceae; Trichophyton. OX NCBI_TaxID=1215330 {ECO:0000313|EMBL:EZF55411.1, ECO:0000313|Proteomes:UP000023758}; RN [1] {ECO:0000313|EMBL:EZF55411.1, ECO:0000313|Proteomes:UP000023758} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=CBS 288.86 {ECO:0000313|EMBL:EZF55411.1, RC ECO:0000313|Proteomes:UP000023758}; RG The Broad Institute Genomics Platform; RA Cuomo C.A., White T.C., Graser Y., Martinez-Rossi N., Heitman J., RA Young S.K., Zeng Q., Gargeya S., Abouelleil A., Alvarado L., Chapman S.B., RA Gainer-Dewar J., Goldberg J., Griggs A., Gujja S., Hansen M., Howarth C., RA Imamovic A., Larimer J., Martinez D., Murphy C., Pearson M.D., RA Persinoti G., Poon T., Priest M., Roberts A.D., Saif S., Shea T.D., RA Sykes S.N., Wortman J., Nusbaum C., Birren B.; RT "The Genome Sequence of Trichophyton rubrum (morphotype fischeri) CBS RT 288.86."; RL Submitted (FEB-2014) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Involved in the import of nuclear-targeted proteins into the CC nucleus and the export of poly(A) RNA out of the nucleus. Has a role in CC the endoplasmic reticulum-associated degradation (ERAD) pathway. CC {ECO:0000256|ARBA:ARBA00003577}. CC -!- SUBCELLULAR LOCATION: Cytoplasm, perinuclear region CC {ECO:0000256|ARBA:ARBA00004556}. Endoplasmic reticulum membrane CC {ECO:0000256|ARBA:ARBA00004397}; Peripheral membrane protein CC {ECO:0000256|ARBA:ARBA00004397}; Cytoplasmic side CC {ECO:0000256|ARBA:ARBA00004397}. Membrane CC {ECO:0000256|ARBA:ARBA00004287}; Peripheral membrane protein CC {ECO:0000256|ARBA:ARBA00004287}; Cytoplasmic side CC {ECO:0000256|ARBA:ARBA00004287}. Nucleus membrane CC {ECO:0000256|ARBA:ARBA00004335}; Peripheral membrane protein CC {ECO:0000256|ARBA:ARBA00004335}; Cytoplasmic side CC {ECO:0000256|ARBA:ARBA00004335}. CC -!- SIMILARITY: Belongs to the NPL4 family. CC {ECO:0000256|ARBA:ARBA00011025}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; KK207751; EZF55411.1; -; Genomic_DNA. DR EnsemblFungi; EZF55411; EZF55411; H103_02041. DR HOGENOM; CLU_017172_0_0_1; -. DR Proteomes; UP000023758; Unassembled WGS sequence. DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell. DR GO; GO:0031965; C:nuclear membrane; IEA:UniProtKB-SubCell. DR GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell. DR GO; GO:0051028; P:mRNA transport; IEA:UniProtKB-KW. DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW. DR GO; GO:0006511; P:ubiquitin-dependent protein catabolic process; IEA:InterPro. DR CDD; cd08061; MPN_NPL4; 1. DR InterPro; IPR037518; MPN. DR InterPro; IPR016563; Npl4. DR InterPro; IPR007717; NPL4_C. DR InterPro; IPR007716; NPL4_Zn-bd_put. DR InterPro; IPR029071; Ubiquitin-like_domsf. DR Pfam; PF05021; NPL4; 1. DR Pfam; PF05020; zf-NPL4; 1. DR PIRSF; PIRSF010052; Polyub_prc_Npl4; 1. DR SUPFAM; SSF54236; SSF54236; 1. DR PROSITE; PS50249; MPN; 1. PE 3: Inferred from homology; KW Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824}; KW mRNA transport {ECO:0000256|ARBA:ARBA00022816}; KW Protein transport {ECO:0000256|ARBA:ARBA00023010}; KW Translocation {ECO:0000256|ARBA:ARBA00023010}; KW Transport {ECO:0000256|ARBA:ARBA00022448}. FT DOMAIN 270..407 FT /note="MPN" FT /evidence="ECO:0000259|PROSITE:PS50249" FT REGION 40..62 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 93..141 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 608..652 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 42..62 FT /note="Polar" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 93..107 FT /note="Polar" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 108..128 FT /note="Polyampholyte" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 619..641 FT /note="Polar" FT /evidence="ECO:0000256|SAM:MobiDB-lite" SQ SEQUENCE 652 AA; 72591 MW; 9575811423924BF8 CRC64; MASPRPIILR FESRNGQFRL TVSPTEQFTA LLPKILENLP KDTDPTTVSL SNKPIGTGGQ ERNLTTLKGI SIQRVGLSHG DKLFVGYEEQ KSTANGSLNG QTGATKKQES SHRLDGGAVP ERDDSSSTKR PTSPTAIIKN PWEIVRQSDL DNRLDKKDGK IPRSLDQKMC RHGPKGMCDY CMPLEPYAPE YLAEKKIKHL SFNSYLRKIN SSTNKPELKS SYMPPLSEPF YRVRKDCPSG HPAWPEGICT KCQPSAITLQ PQQFRMVDHV EFSSPDLINS LLDFWRKTGS QRIGFLYGTY EEYTEVPLGI KAVVQAIYEP PQVDEVDGVT LHEWNNEKDV DHVAKLCGME KIGVIFTDLI DAGAGDGTVV CKRHIDSYYL SSLEVVFASQ LQARNPKPCK WSETGQFGSN FVTCVLSGDE NGAISVCAYQ ASNSAVEMVR ADIIEPSADP SVMLVQQEDE LNNANITRYI PEVFYRRINE YKVSVQENAK PSFPVEYLFV TLTHGFPTTP TTVFTDTSFP IENREFIGES QDLRRVASKL TDSSDPNTII KAVSNFHLLT FLHGMGILNE DEEALLCTVA TKHDPADGIQ LLNTAGWATL VTILQESGET PPKRSWPFKR QSPISSSFHN SSHNSNSDGE QLAKRFRGAS LE //