ID A0A014KZP4_9ACTO Unreviewed; 278 AA. AC A0A014KZP4; DT 11-JUN-2014, integrated into UniProtKB/TrEMBL. DT 11-JUN-2014, sequence version 1. DT 29-OCT-2014, entry version 4. DE RecName: Full=Undecaprenyl-diphosphatase {ECO:0000256|HAMAP-Rule:MF_01006}; DE EC=3.6.1.27 {ECO:0000256|HAMAP-Rule:MF_01006}; DE AltName: Full=Bacitracin resistance protein {ECO:0000256|HAMAP-Rule:MF_01006}; DE AltName: Full=Undecaprenyl pyrophosphate phosphatase {ECO:0000256|HAMAP-Rule:MF_01006}; GN Name=uppP {ECO:0000256|HAMAP-Rule:MF_01006}; GN ORFNames=Z951_41335 {ECO:0000313|EMBL:EXU62476.1}; OS Streptomyces sp. PRh5. OC Bacteria; Actinobacteria; Actinobacteridae; Actinomycetales; OC Streptomycineae; Streptomycetaceae; Streptomyces. OX NCBI_TaxID=1158056 {ECO:0000313|EMBL:EXU62476.1}; RN [1] {ECO:0000313|EMBL:EXU62476.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=PRh5 {ECO:0000313|EMBL:EXU62476.1}; RA Zhu D., Yang H., Wang Y., Zhang Z., Yan R.; RT "Whole-genome shotgun assembly and analysis of the genome of RT Streptomyces sp. PRh5, a strain for production of geldanamycin, RT nigericin and nocardamine."; RL Submitted (JAN-2014) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Catalyzes the dephosphorylation of undecaprenyl CC diphosphate (UPP). Confers resistance to bacitracin. CC {ECO:0000256|HAMAP-Rule:MF_01006}. CC -!- CATALYTIC ACTIVITY: Ditrans,octacis-undecaprenyl diphosphate + CC H(2)O = ditrans,octacis-undecaprenyl phosphate + phosphate. CC {ECO:0000256|HAMAP-Rule:MF_01006, ECO:0000256|SAAS:SAAS00094251}. CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|HAMAP- CC Rule:MF_01006}; Multi-pass membrane protein {ECO:0000256|HAMAP- CC Rule:MF_01006}. CC -!- MISCELLANEOUS: Bacitracin is thought to be involved in the CC inhibition of peptidoglycan synthesis by sequestering undecaprenyl CC diphosphate, thereby reducing the pool of lipid carrier available. CC {ECO:0000256|HAMAP-Rule:MF_01006}. CC -!- SIMILARITY: Belongs to the UppP family. {ECO:0000256|HAMAP- CC Rule:MF_01006}. CC -!- CAUTION: The sequence shown here is derived from an CC EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is CC preliminary data. {ECO:0000313|EMBL:EXU62476.1}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; JABQ01000103; EXU62476.1; -; Genomic_DNA. PE 3: Inferred from homology; KW Antibiotic resistance {ECO:0000256|HAMAP-Rule:MF_01006, KW ECO:0000256|SAAS:SAAS00094259}; KW Cell membrane {ECO:0000256|HAMAP-Rule:MF_01006, KW ECO:0000256|SAAS:SAAS00094249}; KW Cell shape {ECO:0000256|HAMAP-Rule:MF_01006, KW ECO:0000256|SAAS:SAAS00094237}; KW Cell wall biogenesis/degradation {ECO:0000256|HAMAP-Rule:MF_01006, KW ECO:0000256|SAAS:SAAS00094256}; KW Hydrolase {ECO:0000256|HAMAP-Rule:MF_01006, KW ECO:0000256|SAAS:SAAS00094246}; KW Membrane {ECO:0000256|HAMAP-Rule:MF_01006, KW ECO:0000256|SAAS:SAAS00094254}; KW Peptidoglycan synthesis {ECO:0000256|HAMAP-Rule:MF_01006, KW ECO:0000256|SAAS:SAAS00094258}; KW Transmembrane {ECO:0000256|HAMAP-Rule:MF_01006, KW ECO:0000256|SAAS:SAAS00094243}; KW Transmembrane helix {ECO:0000256|HAMAP-Rule:MF_01006, KW ECO:0000256|SAAS:SAAS00094252}. FT TRANSMEM 46 66 Helical. {ECO:0000256|HAMAP-Rule: FT MF_01006}. FT TRANSMEM 95 115 Helical. {ECO:0000256|HAMAP-Rule: FT MF_01006}. FT TRANSMEM 119 139 Helical. {ECO:0000256|HAMAP-Rule: FT MF_01006}. FT TRANSMEM 153 173 Helical. {ECO:0000256|HAMAP-Rule: FT MF_01006}. FT TRANSMEM 191 211 Helical. {ECO:0000256|HAMAP-Rule: FT MF_01006}. FT TRANSMEM 225 245 Helical. {ECO:0000256|HAMAP-Rule: FT MF_01006}. FT TRANSMEM 256 276 Helical. {ECO:0000256|HAMAP-Rule: FT MF_01006}. SQ SEQUENCE 278 AA; 29085 MW; F672AC00A27DEDC8 CRC64; MSAISIGQAA VLGIVEGITE FLPVSSTGHL KITEGLMGIP VDDASVVGFT AVIQVGAIAA VLVYFFKDIV RIVSAWGRGL AHREQRYHHD YKFAWWVICA TIPIVIVGLA AKPLIEGPLA SLWVVAGSLV AGSGVMWVAD QMGRHKRGED DTGFKDAMLV GCSQILALLF PGFSRSGATM STALILDLDR VAATRLSFFL GIPALTGAGL YELKDAVGAG VGTAPLVVGT AVSFVVAYAS IAWLLKFVAK HSFNAFVVYR VAIGVLLLGL LGTGALTA //