{"results":[{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"P0DI20","uniProtkbId":"CSPL1_OSMLA","entryAudit":{"firstPublicDate":"2012-06-13","lastAnnotationUpdateDate":"2026-11-04","lastSequenceUpdateDate":"2012-06-13","entryVersion":20,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Osmunda lancea","commonName":"Fern","taxonId":90694,"lineage":["Eukaryota","Viridiplantae","Streptophyta","Embryophyta","Tracheophyta","Polypodiopsida","Polypodiidae","Osmundales","Osmundaceae","Osmunda"]},"proteinExistence":"2: Evidence at transcript level","proteinDescription":{"recommendedName":{"fullName":{"value":"CASP-like protein 2U2"},"shortNames":[{"value":"OlCASPL2U2"}]}},"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250"}],"value":"Homodimer and heterodimers"}],"commentType":"SUBUNIT"},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000250"}],"value":"Cell membrane","id":"SL-0039"},"topology":{"evidences":[{"evidenceCode":"ECO:0000250"}],"value":"Multi-pass membrane protein","id":"SL-9909"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Belongs to the Casparian strip membrane proteins (CASP) family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":203,"modifier":"EXACT"}},"description":"CASP-like protein 2U2","featureId":"PRO_0000417789"},{"type":"Topological domain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":27,"modifier":"EXACT"}},"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":28,"modifier":"EXACT"},"end":{"value":48,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Topological domain","location":{"start":{"value":49,"modifier":"EXACT"},"end":{"value":73,"modifier":"EXACT"}},"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":74,"modifier":"EXACT"},"end":{"value":94,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Topological domain","location":{"start":{"value":95,"modifier":"EXACT"},"end":{"value":108,"modifier":"EXACT"}},"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":109,"modifier":"EXACT"},"end":{"value":129,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Topological domain","location":{"start":{"value":130,"modifier":"EXACT"},"end":{"value":163,"modifier":"EXACT"}},"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":164,"modifier":"EXACT"},"end":{"value":184,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Topological domain","location":{"start":{"value":185,"modifier":"EXACT"},"end":{"value":203,"modifier":"EXACT"}},"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Region","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":21,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Glycosylation","location":{"start":{"value":51,"modifier":"EXACT"},"end":{"value":51,"modifier":"EXACT"}},"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}],"featureId":""}],"keywords":[{"id":"KW-1003","category":"Cellular component","name":"Cell membrane"},{"id":"KW-0325","category":"PTM","name":"Glycoprotein"},{"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"id":"KW-1133","category":"Domain","name":"Transmembrane helix"}],"references":[{"referenceNumber":1,"citation":{"id":"CI-8VREBABMF8J60","citationType":"submission","authors":["Kakugawa-Yatabe Y.","Tsutsumi C.","Hirayama Y.","Kato M."],"title":"cDNA library of Osmunda lancea.","publicationDate":"JUL-2010","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]"],"referenceComments":[{"value":"Leaf","type":"TISSUE"}]},{"referenceNumber":2,"citation":{"id":"24920445","citationType":"journal article","authors":["Roppolo D.","Boeckmann B.","Pfister A.","Boutet E.","Rubio M.C.","Denervaud-Tendon V.","Vermeer J.E.","Gheyselinck J.","Xenarios I.","Geldner N."],"citationCrossReferences":[{"database":"PubMed","id":"24920445"},{"database":"DOI","id":"10.1104/pp.114.239137"}],"title":"Functional and evolutionary analysis of the CASPARIAN STRIP MEMBRANE DOMAIN PROTEIN family.","publicationDate":"2014","journal":"Plant Physiol.","firstPage":"1709","lastPage":"1722","volume":"165"},"referencePositions":["GENE FAMILY","NOMENCLATURE"]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"FS995965","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"AlphaFoldDB","id":"P0DI20","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"P0DI20","properties":[{"key":"Description","value":"-"}]},{"database":"GlyCosmos","id":"P0DI20","properties":[{"key":"glycosylation","value":"1 site, No reported glycans"}]},{"database":"GO","id":"GO:0005886","properties":[{"key":"GoTerm","value":"C:plasma membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"InterPro","id":"IPR006459","properties":[{"key":"EntryName","value":"CASP/CASPL"}]},{"database":"InterPro","id":"IPR006702","properties":[{"key":"EntryName","value":"CASP_dom"}]},{"database":"NCBIfam","id":"TIGR01569","properties":[{"key":"EntryName","value":"A_tha_TIGR01569"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR33573:SF30","properties":[{"key":"EntryName","value":"CASP-LIKE PROTEIN 2C1-RELATED"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR33573","properties":[{"key":"EntryName","value":"CASP-LIKE PROTEIN 4A4"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF04535","properties":[{"key":"EntryName","value":"CASP_dom"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MGGFVDDGAAGLAPSHGSSRAGRGLEGAGVFLRFVASLLSIAGLMLLVKDNQTVQQMVATEAVTLETKYSDISAFVFLLYTNGLVAVYCFFLALASVFSLIASARSGKLAGWVTFVLDQGLAYVLLAAAAASTEVLYLAENGDLKTSWAEICSQFGHFCHMARASIVVSFLSMLAMAVLSVMSAQQLFSKYRRPMTAKTAQDI","length":203,"molWeight":21544,"crc64":"75E6D016C2229B8D","md5":"29835FBC6AD43CBFBD01B1B8E775B93B"},"extraAttributes":{"countByCommentType":{"SUBUNIT":1,"SUBCELLULAR LOCATION":1,"SIMILARITY":1},"countByFeatureType":{"Chain":1,"Topological domain":5,"Transmembrane":4,"Region":1,"Glycosylation":1},"uniParcId":"UPI00025F5337"}},{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"P0DI21","uniProtkbId":"CSPL2_OSMLA","entryAudit":{"firstPublicDate":"2012-06-13","lastAnnotationUpdateDate":"2025-02-05","lastSequenceUpdateDate":"2012-06-13","entryVersion":19,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Osmunda lancea","commonName":"Fern","taxonId":90694,"lineage":["Eukaryota","Viridiplantae","Streptophyta","Embryophyta","Tracheophyta","Polypodiopsida","Polypodiidae","Osmundales","Osmundaceae","Osmunda"]},"proteinExistence":"2: Evidence at transcript level","proteinDescription":{"recommendedName":{"fullName":{"value":"CASP-like protein 2U1"},"shortNames":[{"value":"OlCASPL2U1"}]}},"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250"}],"value":"Homodimer and heterodimers"}],"commentType":"SUBUNIT"},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000250"}],"value":"Cell membrane","id":"SL-0039"},"topology":{"evidences":[{"evidenceCode":"ECO:0000250"}],"value":"Multi-pass membrane protein","id":"SL-9909"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Belongs to the Casparian strip membrane proteins (CASP) family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":177,"modifier":"EXACT"}},"description":"CASP-like protein 2U1","featureId":"PRO_0000417790"},{"type":"Transmembrane","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":21,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Topological domain","location":{"start":{"value":22,"modifier":"EXACT"},"end":{"value":48,"modifier":"EXACT"}},"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":49,"modifier":"EXACT"},"end":{"value":69,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Topological domain","location":{"start":{"value":70,"modifier":"EXACT"},"end":{"value":80,"modifier":"EXACT"}},"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":81,"modifier":"EXACT"},"end":{"value":101,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Topological domain","location":{"start":{"value":102,"modifier":"EXACT"},"end":{"value":131,"modifier":"EXACT"}},"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":132,"modifier":"EXACT"},"end":{"value":152,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Topological domain","location":{"start":{"value":153,"modifier":"EXACT"},"end":{"value":177,"modifier":"EXACT"}},"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000255"}]}],"keywords":[{"id":"KW-1003","category":"Cellular component","name":"Cell membrane"},{"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"id":"KW-1133","category":"Domain","name":"Transmembrane helix"}],"references":[{"referenceNumber":1,"citation":{"id":"CI-8VREBABMF8J60","citationType":"submission","authors":["Kakugawa-Yatabe Y.","Tsutsumi C.","Hirayama Y.","Kato M."],"title":"cDNA library of Osmunda lancea.","publicationDate":"JUL-2010","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]"],"referenceComments":[{"value":"Leaf","type":"TISSUE"}]},{"referenceNumber":2,"citation":{"id":"24920445","citationType":"journal article","authors":["Roppolo D.","Boeckmann B.","Pfister A.","Boutet E.","Rubio M.C.","Denervaud-Tendon V.","Vermeer J.E.","Gheyselinck J.","Xenarios I.","Geldner N."],"citationCrossReferences":[{"database":"PubMed","id":"24920445"},{"database":"DOI","id":"10.1104/pp.114.239137"}],"title":"Functional and evolutionary analysis of the CASPARIAN STRIP MEMBRANE DOMAIN PROTEIN family.","publicationDate":"2014","journal":"Plant Physiol.","firstPage":"1709","lastPage":"1722","volume":"165"},"referencePositions":["GENE FAMILY","NOMENCLATURE"]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"FS994350","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"AlphaFoldDB","id":"P0DI21","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"P0DI21","properties":[{"key":"Description","value":"-"}]},{"database":"GO","id":"GO:0005886","properties":[{"key":"GoTerm","value":"C:plasma membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"InterPro","id":"IPR006459","properties":[{"key":"EntryName","value":"CASP/CASPL"}]},{"database":"InterPro","id":"IPR006702","properties":[{"key":"EntryName","value":"CASP_dom"}]},{"database":"NCBIfam","id":"TIGR01569","properties":[{"key":"EntryName","value":"A_tha_TIGR01569"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR33573:SF30","properties":[{"key":"EntryName","value":"CASP-LIKE PROTEIN 2C1-RELATED"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR33573","properties":[{"key":"EntryName","value":"CASP-LIKE PROTEIN 4A4"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF04535","properties":[{"key":"EntryName","value":"CASP_dom"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MVLRIVASLLSIAALVLMAKDKQVVYLNLAGEELTLEAKHSYVEAFVYLVYSNGLVAIYCFLLVFALVFRLIDKAGCGKSAAWIIFLLDQGLAYVLLAAAAASTEVAYVAKRGNNKVGWSEVCSTFGHFCNLVGVSIVITFISVLAMATLSVMSARRLFKTYGPERKQISSNDAPAI","length":177,"molWeight":19166,"crc64":"B4B2678AEC944098","md5":"AF0B4E55A3040AF34D8E16D1D6DBBA61"},"extraAttributes":{"countByCommentType":{"SUBUNIT":1,"SUBCELLULAR LOCATION":1,"SIMILARITY":1},"countByFeatureType":{"Chain":1,"Transmembrane":4,"Topological domain":4},"uniParcId":"UPI00025F533A"}},{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"P0DJI7","uniProtkbId":"CSPL3_OSMLA","entryAudit":{"firstPublicDate":"2012-06-13","lastAnnotationUpdateDate":"2023-11-08","lastSequenceUpdateDate":"2012-06-13","entryVersion":18,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Osmunda lancea","commonName":"Fern","taxonId":90694,"lineage":["Eukaryota","Viridiplantae","Streptophyta","Embryophyta","Tracheophyta","Polypodiopsida","Polypodiidae","Osmundales","Osmundaceae","Osmunda"]},"proteinExistence":"2: Evidence at transcript level","proteinDescription":{"recommendedName":{"fullName":{"value":"CASP-like protein 3"}}},"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250"}],"value":"Homodimer and heterodimers"}],"commentType":"SUBUNIT"},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000250"}],"value":"Cell membrane","id":"SL-0039"},"topology":{"evidences":[{"evidenceCode":"ECO:0000250"}],"value":"Multi-pass membrane protein","id":"SL-9909"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Belongs to the Casparian strip membrane proteins (CASP) family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":167,"modifier":"EXACT"}},"description":"CASP-like protein 3","featureId":"PRO_0000417791"},{"type":"Topological domain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":2,"modifier":"EXACT"}},"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":3,"modifier":"EXACT"},"end":{"value":23,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Topological domain","location":{"start":{"value":24,"modifier":"EXACT"},"end":{"value":48,"modifier":"EXACT"}},"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":49,"modifier":"EXACT"},"end":{"value":69,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Topological domain","location":{"start":{"value":70,"modifier":"EXACT"},"end":{"value":80,"modifier":"EXACT"}},"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":81,"modifier":"EXACT"},"end":{"value":101,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Topological domain","location":{"start":{"value":102,"modifier":"EXACT"},"end":{"value":137,"modifier":"EXACT"}},"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":138,"modifier":"EXACT"},"end":{"value":158,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Topological domain","location":{"start":{"value":159,"modifier":"EXACT"},"end":{"value":167,"modifier":"EXACT"}},"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000255"}]}],"keywords":[{"id":"KW-1003","category":"Cellular component","name":"Cell membrane"},{"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"id":"KW-1133","category":"Domain","name":"Transmembrane helix"}],"references":[{"referenceNumber":1,"citation":{"id":"CI-8VREBABMF8J60","citationType":"submission","authors":["Kakugawa-Yatabe Y.","Tsutsumi C.","Hirayama Y.","Kato M."],"title":"cDNA library of Osmunda lancea.","publicationDate":"JUL-2010","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]"],"referenceComments":[{"value":"Leaf","type":"TISSUE"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"FS994861","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"AlphaFoldDB","id":"P0DJI7","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"P0DJI7","properties":[{"key":"Description","value":"-"}]},{"database":"GO","id":"GO:0005886","properties":[{"key":"GoTerm","value":"C:plasma membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"InterPro","id":"IPR006459","properties":[{"key":"EntryName","value":"CASP/CASPL"}]},{"database":"InterPro","id":"IPR006702","properties":[{"key":"EntryName","value":"CASP_dom"}]},{"database":"NCBIfam","id":"TIGR01569","properties":[{"key":"EntryName","value":"A_tha_TIGR01569"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR33573:SF50","properties":[{"key":"EntryName","value":"CASP-LIKE PROTEIN 4A3"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR33573","properties":[{"key":"EntryName","value":"CASP-LIKE PROTEIN 4A4"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF04535","properties":[{"key":"EntryName","value":"CASP_dom"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MKIIAIAPRIGAAVLSLVAFSVMASTGERRSGAGSTFKVKFSDFQAYNYLIALNVILFVYSTVQLVMLVNSNHNSSFSSPFKWVLGVYICDQLLAFLLFSASSSAATASELSRHGLHNIWPPACATWKLWTFCSKAEAAVAMSFLSSFFIITSSILSGYHLSKVPAV","length":167,"molWeight":18102,"crc64":"F8A5063239B93A43","md5":"F917E87002F14C0CD04A870BFD5E5D66"},"extraAttributes":{"countByCommentType":{"SUBUNIT":1,"SUBCELLULAR LOCATION":1,"SIMILARITY":1},"countByFeatureType":{"Chain":1,"Topological domain":5,"Transmembrane":4},"uniParcId":"UPI00025F533C"}}]}