{"results":[{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0A7K8KKF9","uniProtkbId":"A0A7K8KKF9_9AVES","entryAudit":{"firstPublicDate":"2021-04-07","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2021-04-07","entryVersion":18,"sequenceVersion":1},"annotationScore":5.0,"organism":{"scientificName":"Ardeotis kori","taxonId":89386,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"NXE17569.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000560386"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Archelosauria","Archosauria","Dinosauria","Saurischia","Theropoda","Coelurosauria","Aves","Neognathae","Neoaves","Otidimorphae","Otidiformes","Otididae","Ardeotis"]},"proteinExistence":"3: Inferred from homology","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00041096"}],"value":"Pancreatic lipase-related protein 2"},"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00039152"}],"value":"3.1.1.26"}]},"alternativeNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00042032"}],"value":"Cytotoxic T lymphocyte lipase"}},{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00042409"}],"value":"Galactolipase"}},{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00031485"}],"value":"Triacylglycerol lipase"}}],"flag":"Fragment"},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"NXE17569.1"}],"value":"Pnlip"},"orfNames":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"NXE17569.1"}],"value":"ARDKOR_R10202"}]}],"comments":[{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"(9Z-octadecenoyl)-glycerol + H2O = glycerol + (9Z)-octadecenoate + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:39955"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:17754"},{"database":"ChEBI","id":"CHEBI:30823"},{"database":"ChEBI","id":"CHEBI:75937"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00047270"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:39956"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00047270"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"1,2,3-trioctanoylglycerol + H2O = dioctanoylglycerol + octanoate + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:47864"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:25646"},{"database":"ChEBI","id":"CHEBI:76978"},{"database":"ChEBI","id":"CHEBI:88066"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00049290"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:47865"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00049290"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"1,2,3-tripropanoylglycerol + H2O = dipropanoylglycerol + propanoate + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:48024"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:17272"},{"database":"ChEBI","id":"CHEBI:88153"},{"database":"ChEBI","id":"CHEBI:88155"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00047744"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:48025"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00047744"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"1,2-didecanoylglycerol + H2O = decanoylglycerol + decanoate + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:48596"},{"database":"ChEBI","id":"CHEBI:11152"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:27689"},{"database":"ChEBI","id":"CHEBI:90605"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00047618"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:48597"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00047618"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"1,2-didodecanoyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + H2O = dodecanoyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + dodecanoate + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:48516"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:18262"},{"database":"ChEBI","id":"CHEBI:90337"},{"database":"ChEBI","id":"CHEBI:90359"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00047296"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:48517"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00047296"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"1,2-didodecanoyl-3-beta-D-galactosyl-sn-glycerol + H2O = dodecanoyl-3-beta-D-galactosyl-sn-glycerol + dodecanoate + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:48540"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:18262"},{"database":"ChEBI","id":"CHEBI:90340"},{"database":"ChEBI","id":"CHEBI:90515"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00049420"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:48541"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00049420"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"1,2-dioctanoyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + H2O = octanoyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + octanoate + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:48692"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:25646"},{"database":"ChEBI","id":"CHEBI:90457"},{"database":"ChEBI","id":"CHEBI:90768"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00049076"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:48693"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00049076"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"1,2-dioctanoyl-3-O-beta-D-galactosyl-sn-glycerol + H2O = octanoyl-3-(beta-D-galactosyl)-sn-glycerol + octanoate + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:48696"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:25646"},{"database":"ChEBI","id":"CHEBI:90453"},{"database":"ChEBI","id":"CHEBI:90769"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00048268"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:48697"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00048268"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"1-(9Z-octadecenoyl)-glycerol + H2O = glycerol + (9Z)-octadecenoate + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:38487"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:17754"},{"database":"ChEBI","id":"CHEBI:30823"},{"database":"ChEBI","id":"CHEBI:75342"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00047438"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:38488"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00047438"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"1-beta-D-galactosyl-2,3-didodecanoyl-sn-glycerol + H2O = 1-beta-D-galactosyl-dodecanoyl-sn-glycerol + dodecanoate + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:48536"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:18262"},{"database":"ChEBI","id":"CHEBI:90342"},{"database":"ChEBI","id":"CHEBI:90514"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00036575"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:48537"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00036575"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"a 1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol + 2 H2O = 3-beta-D-galactosyl-sn-glycerol + 2 a fatty acid + 2 H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:13189"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:15754"},{"database":"ChEBI","id":"CHEBI:17615"},{"database":"ChEBI","id":"CHEBI:28868"}],"ecNumber":"3.1.1.26","evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00036503"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:13190"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00036503"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"a 1,2-diacyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + H2O = acyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + a fatty acid + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:48372"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:28396"},{"database":"ChEBI","id":"CHEBI:28868"},{"database":"ChEBI","id":"CHEBI:90310"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00048139"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:48373"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00048139"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a monoacyl-sn-glycero-3-phosphocholine + a fatty acid + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:44664"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:28868"},{"database":"ChEBI","id":"CHEBI:57643"},{"database":"ChEBI","id":"CHEBI:84465"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00049154"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:44665"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00049154"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"di-(9Z)-octadecenoylglycerol + H2O = (9Z-octadecenoyl)-glycerol + (9Z)-octadecenoate + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:47868"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:30823"},{"database":"ChEBI","id":"CHEBI:75937"},{"database":"ChEBI","id":"CHEBI:75945"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00047741"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:47869"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00047741"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"long chain 1,2-diacyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + H2O = long chain acyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + a fatty acid + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:48708"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:28868"},{"database":"ChEBI","id":"CHEBI:90463"},{"database":"ChEBI","id":"CHEBI:90774"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00049352"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:48709"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00049352"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"long chain 1,2-diacyl-3-O-beta-D-galactosyl-sn-glycerol + H2O = long chain acyl-3-O-beta-D-galactosyl-sn-glycerol + a fatty acid + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:48700"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:28868"},{"database":"ChEBI","id":"CHEBI:90477"},{"database":"ChEBI","id":"CHEBI:90770"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00048546"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:48701"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00048546"}]}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004879"}],"value":"Glycerolipid metabolism; triacylglycerol degradation"}],"commentType":"PATHWAY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023590"}],"value":"Glycolipid metabolism"}],"commentType":"PATHWAY"},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004487"}],"value":"Cell projection, neuron projection","id":"SL-0518"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004613"}],"value":"Secreted","id":"SL-0243"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00024321"}],"value":"Zymogen granule membrane","id":"SL-0549"},"topology":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00024321"}],"value":"Peripheral membrane protein","id":"SL-9903"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00010701"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU004262"}],"value":"Belongs to the AB hydrolase superfamily. Lipase family"}],"commentType":"SIMILARITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00152"}],"value":"Lacks conserved residue(s) required for the propagation of feature annotation"}],"commentType":"CAUTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"NXE17569.1"}],"value":"The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data"}],"commentType":"CAUTION"}],"features":[{"type":"Domain","location":{"start":{"value":167,"modifier":"EXACT"},"end":{"value":257,"modifier":"EXACT"}},"description":"PLAT","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50095"}]},{"type":"Non-terminal residue","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":1,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"NXE17569.1"}]},{"type":"Non-terminal residue","location":{"start":{"value":257,"modifier":"EXACT"},"end":{"value":257,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"NXE17569.1"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022837"}],"id":"KW-0106","category":"Ligand","name":"Calcium"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023273"}],"id":"KW-0966","category":"Cellular component","name":"Cell projection"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023329"}],"id":"KW-0968","category":"Cellular component","name":"Cytoplasmic vesicle"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023157"}],"id":"KW-1015","category":"PTM","name":"Disulfide bond"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022801"}],"id":"KW-0378","category":"Molecular function","name":"Hydrolase"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022963"}],"id":"KW-0442","category":"Biological process","name":"Lipid degradation"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023098"}],"id":"KW-0443","category":"Biological process","name":"Lipid metabolism"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022723"}],"id":"KW-0479","category":"Ligand","name":"Metal-binding"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000560386"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022525"}],"id":"KW-0964","category":"Cellular component","name":"Secreted"}],"references":[{"referenceNumber":1,"citation":{"id":"CI-90S2KOISV381S","citationType":"submission","authors":["Zhang G."],"title":"Bird 10,000 Genomes (B10K) Project - Family phase.","publicationDate":"SEP-2019","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"NXE17569.1"}],"value":"B10K-CU-031-01","type":"STRAIN"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"NXE17569.1"}],"value":"Muscle","type":"TISSUE"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"NXE17569.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000560386"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"VWPR01000005","properties":[{"key":"ProteinId","value":"NXE17569.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"AlphaFoldDB","id":"A0A7K8KKF9","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000560386","properties":[{"key":"Component","value":"Unassembled WGS sequence"}]},{"database":"GO","id":"GO:0005576","properties":[{"key":"GoTerm","value":"C:extracellular region"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0043005","properties":[{"key":"GoTerm","value":"C:neuron projection"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0042589","properties":[{"key":"GoTerm","value":"C:zymogen granule membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0047714","properties":[{"key":"GoTerm","value":"F:galactolipase activity"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-EC"}]},{"database":"GO","id":"GO:0004465","properties":[{"key":"GoTerm","value":"F:lipoprotein lipase activity"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:0016042","properties":[{"key":"GoTerm","value":"P:lipid catabolic process"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"FunFam","id":"2.60.60.20:FF:000003","properties":[{"key":"EntryName","value":"Triacylglycerol lipase"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.40.50.1820","properties":[{"key":"EntryName","value":"alpha/beta hydrolase"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.60.60.20","properties":[{"key":"EntryName","value":"PLAT/LH2 domain"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR029058","properties":[{"key":"EntryName","value":"AB_hydrolase_fold"}]},{"database":"InterPro","id":"IPR013818","properties":[{"key":"EntryName","value":"Lipase"}]},{"database":"InterPro","id":"IPR001024","properties":[{"key":"EntryName","value":"PLAT/LH2_dom"}]},{"database":"InterPro","id":"IPR036392","properties":[{"key":"EntryName","value":"PLAT/LH2_dom_sf"}]},{"database":"InterPro","id":"IPR000734","properties":[{"key":"EntryName","value":"TAG_lipase"}]},{"database":"PANTHER","id":"PTHR11610","properties":[{"key":"EntryName","value":"LIPASE"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR11610:SF165","properties":[{"key":"EntryName","value":"PANCREATIC LIPASE-RELATED PROTEIN 2"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00151","properties":[{"key":"EntryName","value":"Lipase"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF01477","properties":[{"key":"EntryName","value":"PLAT"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR00821","properties":[{"key":"EntryName","value":"TAGLIPASE"}]},{"database":"SMART","id":"SM00308","properties":[{"key":"EntryName","value":"LH2"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF53474","properties":[{"key":"EntryName","value":"alpha/beta-Hydrolases"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF49723","properties":[{"key":"EntryName","value":"Lipase/lipooxygenase domain (PLAT/LH2 domain)"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50095","properties":[{"key":"EntryName","value":"PLAT"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"LSGLDPAQPYFQGTPILVRLDKSDAEFVDVIHTDSAPTIPYLGFGMTTAIGHLDFFPNGGKQMPGCGKNPVSQIVDLDGIWEGTRDFVACNHLRSYKYYSDSIIYPDGFLGYSCASYDVFDTENCFPCPKEGCPNMGHFADKFKGKIKNDFVKLYLNTGEAKDFALWRYKVTVTLSGRSKVRGYVNIALYGSGGNTRQHQIIEGALQPDNTYTSFVDAEVNVGTVTKVKFLWNNNILNPTFPKLGAATITVQSGENG","length":257,"molWeight":28287,"crc64":"0B4FD99F4B8D4771","md5":"035B6B052B0E8BF5A89BEEFA01A24A68"},"extraAttributes":{"countByCommentType":{"CATALYTIC ACTIVITY":16,"PATHWAY":2,"SUBCELLULAR LOCATION":1,"SIMILARITY":1,"CAUTION":2},"countByFeatureType":{"Domain":1,"Non-terminal residue":2},"uniParcId":"UPI0017E936C8"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0A7K8KL35","uniProtkbId":"A0A7K8KL35_9AVES","entryAudit":{"firstPublicDate":"2021-04-07","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2021-04-07","entryVersion":21,"sequenceVersion":1},"annotationScore":5.0,"organism":{"scientificName":"Ardeotis kori","taxonId":89386,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"NXE17758.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000560386"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Archelosauria","Archosauria","Dinosauria","Saurischia","Theropoda","Coelurosauria","Aves","Neognathae","Neoaves","Otidimorphae","Otidiformes","Otididae","Ardeotis"]},"proteinExistence":"3: Inferred from homology","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00016017"}],"value":"N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D"},"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00012279"}],"value":"3.1.4.54"}]},"flag":"Fragment"},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"NXE17758.1"}],"value":"Napepld"},"orfNames":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"NXE17758.1"}],"value":"ARDKOR_R01678"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00045525"}],"value":"D-type phospholipase that hydrolyzes N-acyl-phosphatidylethanolamines (NAPEs) to produce bioactive N-acylethanolamines/fatty acid ethanolamides (NAEs/FAEs) and phosphatidic acid. Cleaves the terminal phosphodiester bond of diacyl- and alkenylacyl-NAPEs, primarily playing a role in the generation of long-chain saturated and monounsaturated NAEs in the brain. May control NAPE homeostasis in dopaminergic neuron membranes and regulate neuron survival, partly through RAC1 activation. As a regulator of lipid metabolism in the adipose tissue, mediates the crosstalk between adipocytes, gut microbiota and immune cells to control body temperature and weight. In particular, regulates energy homeostasis by promoting cold-induced brown or beige adipocyte differentiation program to generate heat from fatty acids and glucose. Has limited D-type phospholipase activity toward N-acyl lyso-NAPEs"}],"commentType":"FUNCTION"},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"1-O-(1Z-octadecenoyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-N-hexadecanoyl-ethanolamine + H2O = 1-O-(1Z-octadecenoyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + N-hexadecanoylethanolamine + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:56464"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:71464"},{"database":"ChEBI","id":"CHEBI:138663"},{"database":"ChEBI","id":"CHEBI:140452"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00049023"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:56465"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00049023"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"N,1,2-tri-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + H2O = N-(9Z-octadecenoyl) ethanolamine + 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:45532"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:71466"},{"database":"ChEBI","id":"CHEBI:74546"},{"database":"ChEBI","id":"CHEBI:85291"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00048630"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:45533"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00048630"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"N,1-diacyl-sn-glycero-3-phosphoethanolamine + H2O = an N-acylethanolamine + a 1-acyl-sn-glycero-3-phosphate + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:53164"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:52640"},{"database":"ChEBI","id":"CHEBI:57970"},{"database":"ChEBI","id":"CHEBI:85216"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00047528"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:53165"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00047528"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"N,1-dihexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine + H2O = 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + N-hexadecanoylethanolamine + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:45596"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:71464"},{"database":"ChEBI","id":"CHEBI:72860"},{"database":"ChEBI","id":"CHEBI:85334"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00048295"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:45597"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00048295"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"N,1-dihexadecanoyl-sn-glycero-3-phosphoethanolamine + H2O = N-hexadecanoylethanolamine + 1-hexadecanoyl-sn-glycero-3-phosphate + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:45592"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:57518"},{"database":"ChEBI","id":"CHEBI:71464"},{"database":"ChEBI","id":"CHEBI:85335"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00047456"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:45593"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00047456"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + H2O = N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine + 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:45528"},{"database":"ChEBI","id":"CHEBI:2700"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:74546"},{"database":"ChEBI","id":"CHEBI:85277"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00048025"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:45529"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00048025"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-1,2-diacyl-sn-glycero-3-phosphoethanolamine + H2O = N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine + a 1,2-diacyl-sn-glycero-3-phosphate + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:56548"},{"database":"ChEBI","id":"CHEBI:2700"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:58608"},{"database":"ChEBI","id":"CHEBI:140532"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00048796"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:56549"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00048796"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + H2O = N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:45544"},{"database":"ChEBI","id":"CHEBI:2700"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:74544"},{"database":"ChEBI","id":"CHEBI:85223"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00047392"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:45545"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00047392"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"N-butanoyl-1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine + H2O = N-butanoyl ethanolamine + 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:45620"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:72860"},{"database":"ChEBI","id":"CHEBI:85298"},{"database":"ChEBI","id":"CHEBI:85304"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00048938"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:45621"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00048938"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"N-decanoyl-1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine + H2O = N-decanoyl ethanolamine + 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:45608"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:72860"},{"database":"ChEBI","id":"CHEBI:85295"},{"database":"ChEBI","id":"CHEBI:85301"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00048371"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:45609"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00048371"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"N-dodecanoyl-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + H2O = N-dodecanoylethanolamine + 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:45556"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:74546"},{"database":"ChEBI","id":"CHEBI:85263"},{"database":"ChEBI","id":"CHEBI:85294"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00047926"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:45557"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00047926"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"N-hexadecanoyl-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + H2O = N-hexadecanoylethanolamine + 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:45540"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:71464"},{"database":"ChEBI","id":"CHEBI:74546"},{"database":"ChEBI","id":"CHEBI:78097"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00047474"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:45541"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00047474"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"N-hexanoyl-1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine + H2O = N-hexanoyl ethanolamine + 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:45616"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:72860"},{"database":"ChEBI","id":"CHEBI:85297"},{"database":"ChEBI","id":"CHEBI:85303"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00048593"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:45617"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00048593"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"N-octadecanoyl-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + H2O = N-octadecanoyl ethanolamine + 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:45536"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:74546"},{"database":"ChEBI","id":"CHEBI:85292"},{"database":"ChEBI","id":"CHEBI:85299"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00047399"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:45537"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00047399"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"N-octanoyl-1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine + H2O = N-octanoyl ethanolamine + 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:45612"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:72860"},{"database":"ChEBI","id":"CHEBI:85296"},{"database":"ChEBI","id":"CHEBI:85302"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00049463"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:45613"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00049463"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"N-tetradecanoyl-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + H2O = N-tetradecanoylethanolamine + 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:45552"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:74546"},{"database":"ChEBI","id":"CHEBI:85262"},{"database":"ChEBI","id":"CHEBI:85293"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00047759"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:45553"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00047759"}]}]},{"commentType":"COFACTOR","cofactors":[{"name":"Zn(2+)","evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00001947"}],"cofactorCrossReference":{"database":"ChEBI","id":"CHEBI:29105"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00011543"}],"value":"Homodimer. Bile acids promote the assembly of inactive monomers into an active dimer and enable catalysis"}],"commentType":"SUBUNIT"},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004146"}],"value":"Early endosome membrane","id":"SL-0093"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004481"}],"value":"Endosome membrane","id":"SL-0100"},"topology":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004481"}],"value":"Peripheral membrane protein","id":"SL-9903"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004395"}],"value":"Golgi apparatus membrane","id":"SL-0134"},"topology":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004395"}],"value":"Peripheral membrane protein","id":"SL-9903"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004259"}],"value":"Nucleus envelope","id":"SL-0178"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004642"}],"value":"Nucleus, nucleoplasm","id":"SL-0190"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00010127"}],"value":"Belongs to the NAPE-PLD family"}],"commentType":"SIMILARITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"NXE17758.1"}],"value":"The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data"}],"commentType":"CAUTION"}],"features":[{"type":"Signal","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":22,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}]},{"type":"Chain","location":{"start":{"value":23,"modifier":"EXACT"},"end":{"value":473,"modifier":"EXACT"}},"description":"N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"featureId":"PRO_5029551681"},{"type":"Domain","location":{"start":{"value":224,"modifier":"EXACT"},"end":{"value":424,"modifier":"EXACT"}},"description":"Metallo-beta-lactamase","evidences":[{"evidenceCode":"ECO:0000259","source":"Pfam","id":"PF12706"}]},{"type":"Region","location":{"start":{"value":34,"modifier":"EXACT"},"end":{"value":122,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":68,"modifier":"EXACT"},"end":{"value":77,"modifier":"EXACT"}},"description":"Low complexity","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":78,"modifier":"EXACT"},"end":{"value":87,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Non-terminal residue","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":1,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"NXE17758.1"}]},{"type":"Non-terminal residue","location":{"start":{"value":473,"modifier":"EXACT"},"end":{"value":473,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"NXE17758.1"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022990"}],"id":"KW-0007","category":"PTM","name":"Acetylation"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022753"}],"id":"KW-0967","category":"Cellular component","name":"Endosome"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023034"}],"id":"KW-0333","category":"Cellular component","name":"Golgi apparatus"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022801"}],"id":"KW-0378","category":"Molecular function","name":"Hydrolase"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022963"}],"id":"KW-0442","category":"Biological process","name":"Lipid degradation"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023098"}],"id":"KW-0443","category":"Biological process","name":"Lipid metabolism"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023136"}],"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022723"}],"id":"KW-0479","category":"Ligand","name":"Metal-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023242"}],"id":"KW-0539","category":"Cellular component","name":"Nucleus"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022668"}],"id":"KW-0595","category":"Biological process","name":"Phospholipid degradation"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023264"}],"id":"KW-1208","category":"Biological process","name":"Phospholipid metabolism"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000560386"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"id":"KW-0732","category":"Domain","name":"Signal"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022833"}],"id":"KW-0862","category":"Ligand","name":"Zinc"}],"references":[{"referenceNumber":1,"citation":{"id":"CI-90S2KOISV381S","citationType":"submission","authors":["Zhang G."],"title":"Bird 10,000 Genomes (B10K) Project - Family phase.","publicationDate":"SEP-2019","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"NXE17758.1"}],"value":"B10K-CU-031-01","type":"STRAIN"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"NXE17758.1"}],"value":"Muscle","type":"TISSUE"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"NXE17758.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000560386"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"VWPR01000010","properties":[{"key":"ProteinId","value":"NXE17758.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"AlphaFoldDB","id":"A0A7K8KL35","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000560386","properties":[{"key":"Component","value":"Unassembled WGS sequence"}]},{"database":"GO","id":"GO:0031901","properties":[{"key":"GoTerm","value":"C:early endosome membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0000139","properties":[{"key":"GoTerm","value":"C:Golgi membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0005635","properties":[{"key":"GoTerm","value":"C:nuclear envelope"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0005654","properties":[{"key":"GoTerm","value":"C:nucleoplasm"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0070290","properties":[{"key":"GoTerm","value":"F:N-acylphosphatidylethanolamine-specific phospholipase D activity"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-EC"}]},{"database":"GO","id":"GO:0070291","properties":[{"key":"GoTerm","value":"P:N-acylethanolamine metabolic process"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:0070292","properties":[{"key":"GoTerm","value":"P:N-acylphosphatidylethanolamine metabolic process"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"FunFam","id":"3.60.15.10:FF:000016","properties":[{"key":"EntryName","value":"N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D, putative"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.60.15.10","properties":[{"key":"EntryName","value":"Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR001279","properties":[{"key":"EntryName","value":"Metallo-B-lactamas"}]},{"database":"InterPro","id":"IPR036866","properties":[{"key":"EntryName","value":"RibonucZ/Hydroxyglut_hydro"}]},{"database":"PANTHER","id":"PTHR15032","properties":[{"key":"EntryName","value":"N-ACYL-PHOSPHATIDYLETHANOLAMINE-HYDROLYZING PHOSPHOLIPASE D"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR15032:SF4","properties":[{"key":"EntryName","value":"N-ACYL-PHOSPHATIDYLETHANOLAMINE-HYDROLYZING PHOSPHOLIPASE D"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF12706","properties":[{"key":"EntryName","value":"Lactamase_B_2"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF56281","properties":[{"key":"EntryName","value":"Metallo-hydrolase/oxidoreductase"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MVKSRALWSCCLQLAALPSAVSWPGAKPQPFSGFCWRAAEPPPRGWSGTMEEEEDETPQGRRQRQQQHQHQTGSSPQKDMDKKKDEEQPLTVCNQYPKEAVRKRQNLGRGSRGSDSSRTSRKSFRLDYRLEEDVTKSKRGKDGKFVNPWPTWKSPTLPNILKWSLMEKNNSNVPCSKQELDKELPVLKPYFVQKPELAGKTGTGMRVTWLGHASLMVEMDELIFLTDPIFSQRASPTQLMGPKRFRGPPCTVEQLPKIDAVMISHTHYDHLDYNTVTSLNERFGSELRWFVPLGLLDWMQRCGCENVIELDWWEENCVPGHDAVTFVFTPSQHWCKRTATDDNKVLWGSWSVLGPWNRFFFSGDTGYCVAFEQIGKRFGPFDLAAIPIGAYEPRWFMKYQHVDPEEAVRIHIDVQAKKSVAIHWGTFALANEYYLDPPVKLNEALERYGLKKEDFFVLNHGESRDLSTNDGCE","length":473,"molWeight":54322,"crc64":"67A4090D65769F5E","md5":"E651CACF1618C8DB72CDF869F740A2EC"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"CATALYTIC ACTIVITY":16,"COFACTOR":1,"SUBUNIT":1,"SUBCELLULAR LOCATION":1,"SIMILARITY":1,"CAUTION":1},"countByFeatureType":{"Signal":1,"Chain":1,"Domain":1,"Region":1,"Compositional bias":2,"Non-terminal residue":2},"uniParcId":"UPI00183F7026"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0A7K8KME5","uniProtkbId":"A0A7K8KME5_9AVES","entryAudit":{"firstPublicDate":"2021-04-07","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2021-04-07","entryVersion":16,"sequenceVersion":1},"annotationScore":5.0,"organism":{"scientificName":"Ardeotis kori","taxonId":89386,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"NXE17990.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000560386"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Archelosauria","Archosauria","Dinosauria","Saurischia","Theropoda","Coelurosauria","Aves","Neognathae","Neoaves","Otidimorphae","Otidiformes","Otididae","Ardeotis"]},"proteinExistence":"3: Inferred from homology","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00072984"}],"value":"Peroxisomal coenzyme A diphosphatase NUDT7"},"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00044967"}],"value":"3.6.1.77"}]},"alternativeNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00079598"}],"value":"Nucleoside diphosphate-linked moiety X motif 7"}}],"flag":"Fragment"},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"NXE17990.1"}],"value":"Nudt7"},"orfNames":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"NXE17990.1"}],"value":"ARDKOR_R11952"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00059426"}],"value":"Fatty acyl-coenzyme A (CoA) diphosphatase that hydrolyzes fatty acyl-CoA to yield acyl-4'-phosphopantetheine and adenosine 3',5'-bisphosphate. Cleaves CoA, CoA esters and oxidized CoA with similar efficiencies. Preferentially hydrolyzes medium-chain acyl-CoAs and bile acid-CoAs. Has no activity toward NDP-sugars, CDP-alcohols, (deoxy)nucleoside 5'-triphosphates, nucleoside 5'-di or monophosphates, diadenosine polyphosphates, NAD, NADH, NADP, NADPH or thymidine-5'-monophospho-p-nitrophenyl ester. May be required to eliminate oxidized CoA from peroxisomes, or regulate CoA and acyl-CoA levels in this organelle in response to metabolic demand. Does not play a role in U8 snoRNA decapping activity. Binds U8 snoRNA. Exhibits decapping activity towards dpCoA-capped RNAs in vitro"}],"commentType":"FUNCTION"},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA + H2O = 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-4'-phosphopantetheine + adenosine 3',5'-bisphosphate + 2 H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:50040"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:58343"},{"database":"ChEBI","id":"CHEBI:63001"},{"database":"ChEBI","id":"CHEBI:132021"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00051749"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:50041"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00051749"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"CoA + H2O = (R)-4'-phosphopantetheine + adenosine 3',5'-bisphosphate + 2 H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:64988"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:57287"},{"database":"ChEBI","id":"CHEBI:58343"},{"database":"ChEBI","id":"CHEBI:61723"}],"ecNumber":"3.6.1.77","evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00044908"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:64989"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00044908"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"a 5'-end CoA-ribonucleoside in mRNA + H2O = a 5'-end phospho-adenosine-phospho-ribonucleoside in mRNA + (R)-4'-phosphopantetheine + 2 H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:67592"},{"database":"Rhea","id":"RHEA-COMP:15719"},{"database":"Rhea","id":"RHEA-COMP:17276"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:61723"},{"database":"ChEBI","id":"CHEBI:144051"},{"database":"ChEBI","id":"CHEBI:172371"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00048667"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:67593"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00048667"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"acetyl-CoA + H2O = S-acetyl-4'-phosphopantetheine + adenosine 3',5'-bisphosphate + 2 H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:64992"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:57288"},{"database":"ChEBI","id":"CHEBI:58343"},{"database":"ChEBI","id":"CHEBI:156266"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00051856"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:64993"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00051856"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"butanoyl-CoA + H2O = S-butanoyl-4'-phosphopantetheine + adenosine 3',5'-bisphosphate + 2 H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:49976"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:57371"},{"database":"ChEBI","id":"CHEBI:58343"},{"database":"ChEBI","id":"CHEBI:132011"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00049284"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:49977"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00049284"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"choloyl-CoA + H2O = S-choloyl-4'-phosphopantetheine + adenosine 3',5'-bisphosphate + 2 H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:50036"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:57373"},{"database":"ChEBI","id":"CHEBI:58343"},{"database":"ChEBI","id":"CHEBI:132020"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00048961"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:50037"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00048961"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"decanoyl-CoA + H2O = decanoyl-4'-phosphopantetheine + adenosine 3',5'-bisphosphate + 2 H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:50020"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:58343"},{"database":"ChEBI","id":"CHEBI:61430"},{"database":"ChEBI","id":"CHEBI:132014"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00050371"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:50021"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00050371"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"dodecanoyl-CoA + H2O = S-dodecanoyl-4'-phosphopantetheine + adenosine 3',5'-bisphosphate + 2 H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:50024"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:57375"},{"database":"ChEBI","id":"CHEBI:58343"},{"database":"ChEBI","id":"CHEBI:132015"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00047757"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:50025"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00047757"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"hexanoyl-CoA + H2O = hexanoyl-4'-phosphopantetheine + adenosine 3',5'-bisphosphate + 2 H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:49980"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:58343"},{"database":"ChEBI","id":"CHEBI:62620"},{"database":"ChEBI","id":"CHEBI:132012"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00047466"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:49981"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00047466"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"malonyl-CoA + H2O = malonyl-4'-phosphopantetheine + adenosine 3',5'-bisphosphate + 2 H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:67468"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:57384"},{"database":"ChEBI","id":"CHEBI:58343"},{"database":"ChEBI","id":"CHEBI:172363"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00047369"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:67469"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00047369"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"octanoyl-CoA + H2O = S-octanoyl-4'-phosphopantetheine + adenosine 3',5'-bisphosphate + 2 H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:50016"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:57386"},{"database":"ChEBI","id":"CHEBI:58343"},{"database":"ChEBI","id":"CHEBI:132013"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00047289"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:50017"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00047289"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"propanoyl-CoA + H2O = propanoyl-4'-phosphopantetheine + adenosine 3',5'-bisphosphate + 2 H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:67464"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:57392"},{"database":"ChEBI","id":"CHEBI:58343"},{"database":"ChEBI","id":"CHEBI:172362"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00047666"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:67465"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00047666"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"succinyl-CoA + H2O = succinyl-4'-phosphopantetheine + adenosine 3',5'-bisphosphate + 2 H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:67472"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:57292"},{"database":"ChEBI","id":"CHEBI:58343"},{"database":"ChEBI","id":"CHEBI:172364"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00048624"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:67473"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00048624"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"tetradecanoyl-CoA + H2O = tetradecanoyl-4'-phosphopantetheine + adenosine 3',5'-bisphosphate + 2 H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:50028"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:57385"},{"database":"ChEBI","id":"CHEBI:58343"},{"database":"ChEBI","id":"CHEBI:132017"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00047403"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:50029"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00047403"}]}]},{"commentType":"COFACTOR","cofactors":[{"name":"Mg(2+)","evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00001946"}],"cofactorCrossReference":{"database":"ChEBI","id":"CHEBI:18420"}}]},{"commentType":"COFACTOR","cofactors":[{"name":"Mn(2+)","evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00001936"}],"cofactorCrossReference":{"database":"ChEBI","id":"CHEBI:29035"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00011245"}],"value":"Monomer"}],"commentType":"SUBUNIT"},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004275"}],"value":"Peroxisome","id":"SL-0204"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00006506"}],"value":"Belongs to the Nudix hydrolase family. PCD1 subfamily"}],"commentType":"SIMILARITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00794"}],"value":"Lacks conserved residue(s) required for the propagation of feature annotation"}],"commentType":"CAUTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"NXE17990.1"}],"value":"The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data"}],"commentType":"CAUTION"}],"features":[{"type":"Domain","location":{"start":{"value":38,"modifier":"EXACT"},"end":{"value":170,"modifier":"EXACT"}},"description":"Nudix hydrolase","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS51462"}]},{"type":"Non-terminal residue","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":1,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"NXE17990.1"}]},{"type":"Non-terminal residue","location":{"start":{"value":244,"modifier":"EXACT"},"end":{"value":244,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"NXE17990.1"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022801"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00794"}],"id":"KW-0378","category":"Molecular function","name":"Hydrolase"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022842"}],"id":"KW-0460","category":"Ligand","name":"Magnesium"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023211"}],"id":"KW-0464","category":"Ligand","name":"Manganese"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022723"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00794"}],"id":"KW-0479","category":"Ligand","name":"Metal-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023140"}],"id":"KW-0576","category":"Cellular component","name":"Peroxisome"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000560386"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022884"}],"id":"KW-0694","category":"Molecular function","name":"RNA-binding"}],"references":[{"referenceNumber":1,"citation":{"id":"CI-90S2KOISV381S","citationType":"submission","authors":["Zhang G."],"title":"Bird 10,000 Genomes (B10K) Project - Family phase.","publicationDate":"SEP-2019","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"NXE17990.1"}],"value":"B10K-CU-031-01","type":"STRAIN"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"NXE17990.1"}],"value":"Muscle","type":"TISSUE"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"NXE17990.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000560386"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"VWPR01000018","properties":[{"key":"ProteinId","value":"NXE17990.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"AlphaFoldDB","id":"A0A7K8KME5","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000560386","properties":[{"key":"Component","value":"Unassembled WGS sequence"}]},{"database":"GO","id":"GO:0005782","properties":[{"key":"GoTerm","value":"C:peroxisomal matrix"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0010945","properties":[{"key":"GoTerm","value":"F:coenzyme A diphosphatase activity"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-EC"}]},{"database":"GO","id":"GO:0000287","properties":[{"key":"GoTerm","value":"F:magnesium ion binding"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0030145","properties":[{"key":"GoTerm","value":"F:manganese ion binding"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0015938","properties":[{"key":"GoTerm","value":"P:coenzyme A catabolic process"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"CDD","id":"cd03426","properties":[{"key":"EntryName","value":"NUDIX_CoAse_Nudt7"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.90.79.10:FF:000049","properties":[{"key":"EntryName","value":"Peroxisomal coenzyme A diphosphatase NUDT7"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.90.79.10","properties":[{"key":"EntryName","value":"Nucleoside Triphosphate Pyrophosphohydrolase"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR045121","properties":[{"key":"EntryName","value":"CoAse"}]},{"database":"InterPro","id":"IPR015797","properties":[{"key":"EntryName","value":"NUDIX_hydrolase-like_dom_sf"}]},{"database":"InterPro","id":"IPR000086","properties":[{"key":"EntryName","value":"NUDIX_hydrolase_dom"}]},{"database":"InterPro","id":"IPR000059","properties":[{"key":"EntryName","value":"NUDIX_hydrolase_NudL_CS"}]},{"database":"PANTHER","id":"PTHR12992","properties":[{"key":"EntryName","value":"NUDIX HYDROLASE"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR12992:SF24","properties":[{"key":"EntryName","value":"PEROXISOMAL COENZYME A DIPHOSPHATASE NUDT7"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00293","properties":[{"key":"EntryName","value":"NUDIX"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF55811","properties":[{"key":"EntryName","value":"Nudix"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS51462","properties":[{"key":"EntryName","value":"NUDIX"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS01293","properties":[{"key":"EntryName","value":"NUDIX_COA"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"LGVSRRSFVFASRESIKQRARLRLREFDVGGKFSHLPLPRAAVLLPLTVRAGRLHLLLTVRSMQLRRSPGEVCFPGGKSEAIDKDEIDTALREAKEEVGLQPEKVEVICRLVPGIDKMNHLVTPVVGFIEDTFQAIPNPDEVSDVFVVPLEYFVKPLHYNTLPYKTKSGYLTMMHCFTYEDHEHNTSFRIWGLTAHFAVFLALIILGKRPTFEVDYDLDNLVSSSENNFMNLYASLYEKKKSNL","length":244,"molWeight":27813,"crc64":"767B3CA9ACFDB82D","md5":"4F7718D56392F15D02838F2106EA227B"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"CATALYTIC ACTIVITY":14,"COFACTOR":2,"SUBUNIT":1,"SUBCELLULAR LOCATION":1,"SIMILARITY":1,"CAUTION":2},"countByFeatureType":{"Domain":1,"Non-terminal residue":2},"uniParcId":"UPI0017BE5AE4"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0A7K8KMW0","uniProtkbId":"A0A7K8KMW0_9AVES","entryAudit":{"firstPublicDate":"2021-04-07","lastAnnotationUpdateDate":"2026-11-04","lastSequenceUpdateDate":"2021-04-07","entryVersion":20,"sequenceVersion":1},"annotationScore":5.0,"organism":{"scientificName":"Ardeotis kori","taxonId":89386,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"NXE18427.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000560386"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Archelosauria","Archosauria","Dinosauria","Saurischia","Theropoda","Coelurosauria","Aves","Neognathae","Neoaves","Otidimorphae","Otidiformes","Otididae","Ardeotis"]},"proteinExistence":"3: Inferred from homology","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00096608"}],"value":"Polyphosphatidylinositol phosphatase SYNJ1"},"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00013044"}],"value":"3.1.3.36"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00012903"}],"value":"3.1.3.95"}]},"alternativeNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00096788"}],"value":"Synaptojanin-1"}}],"flag":"Fragment"},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"NXE18427.1"}],"value":"Synj1"},"orfNames":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"NXE18427.1"}],"value":"ARDKOR_R03174"}]}],"comments":[{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"1,2-dioctanoyl-sn-glycero-3-phospho-(1-D-myo-inositol-4-phosphate) + H2O = 1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + phosphate","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:45836"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:43474"},{"database":"ChEBI","id":"CHEBI:65221"},{"database":"ChEBI","id":"CHEBI:85468"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00095475"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:45837"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00095475"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + H2O = 1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4-bisphosphate) + phosphate","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:43548"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:43474"},{"database":"ChEBI","id":"CHEBI:83416"},{"database":"ChEBI","id":"CHEBI:83417"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00034246"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:43549"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00034246"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1,2-dioctanoyl-sn-glycero-3-phospho-(1-D-myo-inositol-4-phosphate) + phosphate","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:86551"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:43474"},{"database":"ChEBI","id":"CHEBI:83419"},{"database":"ChEBI","id":"CHEBI:85468"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00095745"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:86552"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00095745"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + H2O = 1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + phosphate","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:42308"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:43474"},{"database":"ChEBI","id":"CHEBI:65221"},{"database":"ChEBI","id":"CHEBI:78911"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00052780"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:42309"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00052780"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"1D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O = 1D-myo-inositol 1,3,4-trisphosphate + phosphate","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:11392"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:43474"},{"database":"ChEBI","id":"CHEBI:57895"},{"database":"ChEBI","id":"CHEBI:58414"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00095573"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:11393"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00095573"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"1D-myo-inositol 1,4,5-trisphosphate + H2O = 1D-myo-inositol 1,4-bisphosphate + phosphate","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:19797"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:43474"},{"database":"ChEBI","id":"CHEBI:58282"},{"database":"ChEBI","id":"CHEBI:203600"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00095771"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:19798"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00095771"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + phosphate","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:55652"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:43474"},{"database":"ChEBI","id":"CHEBI:57880"},{"database":"ChEBI","id":"CHEBI:58178"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00036807"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:55653"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00036807"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4-bisphosphate) + phosphate","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:25528"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:43474"},{"database":"ChEBI","id":"CHEBI:57658"},{"database":"ChEBI","id":"CHEBI:57836"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00095800"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:25529"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00095800"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,5-bisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + phosphate","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:39019"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:43474"},{"database":"ChEBI","id":"CHEBI:57795"},{"database":"ChEBI","id":"CHEBI:57923"}],"ecNumber":"3.1.3.95","evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00045090"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:39020"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00045090"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + phosphate","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:12316"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:43474"},{"database":"ChEBI","id":"CHEBI:57880"},{"database":"ChEBI","id":"CHEBI:58088"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00045091"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:12317"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00045091"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + phosphate","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:41147"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:43474"},{"database":"ChEBI","id":"CHEBI:57795"},{"database":"ChEBI","id":"CHEBI:57880"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00095430"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:41148"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00095430"}]}]},{"commentType":"COFACTOR","cofactors":[{"name":"Mg(2+)","evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00001946"}],"cofactorCrossReference":{"database":"ChEBI","id":"CHEBI:18420"}}]},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004556"}],"value":"Cytoplasm, perinuclear region","id":"SL-0198"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004370"}],"value":"Membrane","id":"SL-0162"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00034106"}],"value":"Presynapse","id":"SL-0516"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00008943"}],"value":"Belongs to the synaptojanin family"}],"commentType":"SIMILARITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00009678"}],"value":"In the central section; belongs to the inositol 1,4,5-trisphosphate 5-phosphatase family"}],"commentType":"SIMILARITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"NXE18427.1"}],"value":"The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data"}],"commentType":"CAUTION"}],"features":[{"type":"Domain","location":{"start":{"value":119,"modifier":"EXACT"},"end":{"value":442,"modifier":"EXACT"}},"description":"SAC","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50275"}]},{"type":"Domain","location":{"start":{"value":891,"modifier":"EXACT"},"end":{"value":968,"modifier":"EXACT"}},"description":"RRM","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50102"}]},{"type":"Region","location":{"start":{"value":1026,"modifier":"EXACT"},"end":{"value":1166,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":1196,"modifier":"EXACT"},"end":{"value":1300,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":1536,"modifier":"EXACT"},"end":{"value":1575,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":1027,"modifier":"EXACT"},"end":{"value":1051,"modifier":"EXACT"}},"description":"Low complexity","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":1076,"modifier":"EXACT"},"end":{"value":1094,"modifier":"EXACT"}},"description":"Polar residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":1099,"modifier":"EXACT"},"end":{"value":1121,"modifier":"EXACT"}},"description":"Pro residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":1218,"modifier":"EXACT"},"end":{"value":1231,"modifier":"EXACT"}},"description":"Pro residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":1233,"modifier":"EXACT"},"end":{"value":1242,"modifier":"EXACT"}},"description":"Low complexity","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":1283,"modifier":"EXACT"},"end":{"value":1293,"modifier":"EXACT"}},"description":"Low complexity","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Non-terminal residue","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":1,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"NXE18427.1"}]},{"type":"Non-terminal residue","location":{"start":{"value":1575,"modifier":"EXACT"},"end":{"value":1575,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"NXE18427.1"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023273"}],"id":"KW-0966","category":"Cellular component","name":"Cell projection"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022490"}],"id":"KW-0963","category":"Cellular component","name":"Cytoplasm"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022583"}],"id":"KW-0254","category":"Biological process","name":"Endocytosis"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022801"}],"id":"KW-0378","category":"Molecular function","name":"Hydrolase"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023098"}],"id":"KW-0443","category":"Biological process","name":"Lipid metabolism"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022842"}],"id":"KW-0460","category":"Ligand","name":"Magnesium"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023136"}],"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022723"}],"id":"KW-0479","category":"Ligand","name":"Metal-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022481"}],"id":"KW-0488","category":"PTM","name":"Methylation"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022553"}],"id":"KW-0597","category":"PTM","name":"Phosphoprotein"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000560386"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022884"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00176"}],"id":"KW-0694","category":"Molecular function","name":"RNA-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023018"}],"id":"KW-0770","category":"Cellular component","name":"Synapse"}],"references":[{"referenceNumber":1,"citation":{"id":"CI-90S2KOISV381S","citationType":"submission","authors":["Zhang G."],"title":"Bird 10,000 Genomes (B10K) Project - Family phase.","publicationDate":"SEP-2019","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"NXE18427.1"}],"value":"B10K-CU-031-01","type":"STRAIN"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"NXE18427.1"}],"value":"Muscle","type":"TISSUE"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"NXE18427.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000560386"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"VWPR01000033","properties":[{"key":"ProteinId","value":"NXE18427.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"Proteomes","id":"UP000560386","properties":[{"key":"Component","value":"Unassembled WGS sequence"}]},{"database":"GO","id":"GO:0016020","properties":[{"key":"GoTerm","value":"C:membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0048471","properties":[{"key":"GoTerm","value":"C:perinuclear region of cytoplasm"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0098793","properties":[{"key":"GoTerm","value":"C:presynapse"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0052629","properties":[{"key":"GoTerm","value":"F:phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-EC"}]},{"database":"GO","id":"GO:0004439","properties":[{"key":"GoTerm","value":"F:phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-EC"}]},{"database":"GO","id":"GO:0003723","properties":[{"key":"GoTerm","value":"F:RNA binding"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniRule"}]},{"database":"GO","id":"GO:0017124","properties":[{"key":"GoTerm","value":"F:SH3 domain binding"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:0046856","properties":[{"key":"GoTerm","value":"P:phosphatidylinositol dephosphorylation"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0048488","properties":[{"key":"GoTerm","value":"P:synaptic vesicle endocytosis"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"CDD","id":"cd09098","properties":[{"key":"EntryName","value":"INPP5c_Synj1"},{"key":"MatchStatus","value":"1"}]},{"database":"CDD","id":"cd12719","properties":[{"key":"EntryName","value":"RRM_SYNJ1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.30.70.330:FF:000076","properties":[{"key":"EntryName","value":"Synaptojanin-1 isoform 1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.60.10.10:FF:000003","properties":[{"key":"EntryName","value":"Synaptojanin-1 isoform 1"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.30.70.330","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.60.10.10","properties":[{"key":"EntryName","value":"Endonuclease/exonuclease/phosphatase"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR036691","properties":[{"key":"EntryName","value":"Endo/exonu/phosph_ase_sf"}]},{"database":"InterPro","id":"IPR046985","properties":[{"key":"EntryName","value":"IP5"}]},{"database":"InterPro","id":"IPR000300","properties":[{"key":"EntryName","value":"IPPc"}]},{"database":"InterPro","id":"IPR012677","properties":[{"key":"EntryName","value":"Nucleotide-bd_a/b_plait_sf"}]},{"database":"InterPro","id":"IPR035979","properties":[{"key":"EntryName","value":"RBD_domain_sf"}]},{"database":"InterPro","id":"IPR000504","properties":[{"key":"EntryName","value":"RRM_dom"}]},{"database":"InterPro","id":"IPR002013","properties":[{"key":"EntryName","value":"SAC_dom"}]},{"database":"InterPro","id":"IPR015047","properties":[{"key":"EntryName","value":"SYNJ1/2_RRM"}]},{"database":"InterPro","id":"IPR034971","properties":[{"key":"EntryName","value":"SYNJ1_RRM"}]},{"database":"PANTHER","id":"PTHR11200","properties":[{"key":"EntryName","value":"INOSITOL 5-PHOSPHATASE"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR11200:SF158","properties":[{"key":"EntryName","value":"SYNAPTOJANIN-1"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF08952","properties":[{"key":"EntryName","value":"DUF1866"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF22669","properties":[{"key":"EntryName","value":"Exo_endo_phos2"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF02383","properties":[{"key":"EntryName","value":"Syja_N"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM01165","properties":[{"key":"EntryName","value":"DUF1866"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00128","properties":[{"key":"EntryName","value":"IPPc"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF56219","properties":[{"key":"EntryName","value":"DNase I-like"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF54928","properties":[{"key":"EntryName","value":"RNA-binding domain, RBD"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50102","properties":[{"key":"EntryName","value":"RRM"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50275","properties":[{"key":"EntryName","value":"SAC"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MAFSKGYRVYHKLDPLPFSVIVETRNREECLMFESGAVAVLSSAEKDTIKNTYSKVMDAYGLLGVLRLNLGDTLLHYLVLVTGCMSVGKIQDSEVFRVTSTEFVSLRIDSTDEDRISEVRKVLNSGNFYFAWSATGVSLDLSLNAHRSMQEHTTDNRFFWNQSLHLHLKHYGVNCDDWLLRLMCGGVEIRTIYAAHKQAKACLISRLSCERAGTRFNVRGTNDDGHVANFVETEQVIYLDDSVSSFIQIRGSVPLFWEQPGLQVGSHRVRMSRGFEANAPAFDRHFQTLKNLYGKQIIVNLLGAKEGEHMLSKAFQSHLKASEHSADIKMVNFDYHQMVKGGKAEKLHSVLKPQVQKFLECGFFYFDGKEVKRSQSGTVRTNCLDCLDRTNSVQAFFGLEMLTKQLEVLGLAEKPQLVTRFQEVFRSMWSVNGDSVSKIYAGTGALEGKAKAGKLKDGARSVTRTIQNNFFDSSKQEAIDVLLLGNTLNSDLADKARALLTTSSLRGMSSVKVLKSMCENFYKYAKPKKIRVCVGTWNVNGGKQFRSIAFRNQTLTDWLLDAPKLAGIHEFQDRKSKPVDIFAIGFEEMVELNAGNIVNASTTNQKLWAAELQKTISRDYKYVLLASEQLVGVCLFVFIRPQHAPFIRDVAVDTVKTGMGGATGNKGAVAIRMLFHTSSLCFVCSHFAAGQSQVKERNEDFIEIARKLSFPMGRMLFSHDYIFWCGDFNYRIDIPNEEVKELIRQQNWDPLIAGDQLINQKNSGQIFRGFLEGKINFAPTYKYDLFSDDYDTSEKCRTPAWTDRILWRRRKWPFDRSAEDLDLLNASFHDDSNVPYTWNPGTLLHYGRAELKTSDHRPVVALIDIDIFEIEAEERQKVYKEVIAMQGPPDGTVMVSIRSSSAEENYFDDNLIDDLLQKFASYGEVILIRFVEDKMWVTFLEGSSALNVMNLNGTELLGRIINISLKNPDWIRSLEDEMNLEKINIGLPSSTSSTLLCEDAEVTADYDMEGDVDDYSAEVEEILPQHLQPTSSSGLGTSPSSSPRSSPCQSPTLSDGPTLPVRPSRAPAKTPGPPVSTHTELQPATQQKESSQSLEPKRPPPPRPVAPPARPAPPQRPPPPSGGRSPAPARKEFGGLGAPPSPGVAKREVEAQKSPGTQRKDNLGNTDTCFIQTRAKIISFYQLLCQTVPPRAGVISAPQSHVRPSGARPAPETQTKPAEPPRGSPLLPEPLKPQAAGPAQPTTQPPPVLRMQEPLIPVASHPSQTSAPQSLEPPQPPPRSRSSHSLPSESAPPQQQIKTNGTYGTKLETQLNSDPFEDLSFKLLMSKMQTSVRTSPVPTLNQKELIQLPSATQRNADTLNTVNCMPAMPPIPTFNTSQEHKRSSPNPFITGLNCTNPFTERTPNAGNPFRMETQESEITSHLLEGRAACNPLPSLNPPSCNTSKPVFFVDAPENNFCLRSKSLMVKNVQRKGWVTFDDEENFNVKLKPSNSVPDFQQIGSRNPDLLGTEQNTFLGSDFNFDNDWNKRSTDCFYTMPARRPPAPPVPSRITSNRSPADPFTSLAPKVSRTQDFTET","length":1575,"molWeight":175456,"crc64":"A0D27C70FCAE4DF6","md5":"81A1B54681703AC90116E1C8E67D2BDA"},"extraAttributes":{"countByCommentType":{"CATALYTIC ACTIVITY":11,"COFACTOR":1,"SUBCELLULAR LOCATION":1,"SIMILARITY":2,"CAUTION":1},"countByFeatureType":{"Domain":2,"Region":3,"Compositional bias":6,"Non-terminal residue":2},"uniParcId":"UPI001809B588"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0A7K8KPX5","uniProtkbId":"A0A7K8KPX5_9AVES","entryAudit":{"firstPublicDate":"2021-04-07","lastAnnotationUpdateDate":"2026-11-04","lastSequenceUpdateDate":"2021-04-07","entryVersion":19,"sequenceVersion":1},"annotationScore":5.0,"organism":{"scientificName":"Ardeotis kori","taxonId":89386,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"NXE19108.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000560386"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Archelosauria","Archosauria","Dinosauria","Saurischia","Theropoda","Coelurosauria","Aves","Neognathae","Neoaves","Otidimorphae","Otidiformes","Otididae","Ardeotis"]},"proteinExistence":"3: Inferred from homology","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00071303"}],"value":"Phospholipase ABHD3"},"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00013179"}],"value":"3.1.1.32"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00013278"}],"value":"3.1.1.4"}]},"alternativeNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00082158"}],"value":"Abhydrolase domain-containing protein 3"}}],"flag":"Fragment"},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"NXE19108.1"}],"value":"Abhd3"},"orfNames":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"NXE19108.1"}],"value":"ARDKOR_R10663"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00059841"}],"value":"Phospholipase that may play a role in phospholipids remodeling. May selectively cleave myristate (C14)-containing phosphatidylcholines through its predominant phospholipase 1 activity, cleaving preferentially acyl groups in sn1 position. In parallel, may have a minor phospholipase 2 activity acting on acyl groups in position sn2. In addition to (C14)-containing phosphatidylcholines, may also act on other medium-chain-containing and oxidatively truncated phospholipids"}],"commentType":"FUNCTION"},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"1,2-ditetradecanoyl-sn-glycero-3-phosphocholine + H2O = 1-tetradecanoyl-sn-glycero-3-phosphocholine + tetradecanoate + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:54456"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:30807"},{"database":"ChEBI","id":"CHEBI:45240"},{"database":"ChEBI","id":"CHEBI:64489"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00050145"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:54457"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00050145"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"1,2-ditetradecanoyl-sn-glycero-3-phosphocholine + H2O = 2-tetradecanoyl-sn-glycero-3-phosphocholine + tetradecanoate + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:54404"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:30807"},{"database":"ChEBI","id":"CHEBI:45240"},{"database":"ChEBI","id":"CHEBI:131738"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00052894"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:54405"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00052894"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = 1-O-hexadecyl-sn-glycero-3-phosphocholine + acetate + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:40479"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:30089"},{"database":"ChEBI","id":"CHEBI:44811"},{"database":"ChEBI","id":"CHEBI:64496"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023721"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:40480"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023721"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"1-O-hexadecyl-2-nonadioyl-sn-glycero-3-phosphocholine + H2O = nonanedioate + 1-O-hexadecyl-sn-glycero-3-phosphocholine + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:54552"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:64496"},{"database":"ChEBI","id":"CHEBI:78208"},{"database":"ChEBI","id":"CHEBI:138269"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00050276"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:54553"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00050276"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"1-hexadecanoyl-2-(5-oxopentanoyl)-sn-glycero-3-phosphocholine + H2O = 5-oxopentanoate + 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:40483"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:16120"},{"database":"ChEBI","id":"CHEBI:72998"},{"database":"ChEBI","id":"CHEBI:77890"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00047611"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:40484"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00047611"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"1-hexadecanoyl-2-(9-oxononanoyl)-sn-glycero-3-phosphocholine + H2O = 9-oxononanoate + 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:41179"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:61042"},{"database":"ChEBI","id":"CHEBI:72998"},{"database":"ChEBI","id":"CHEBI:77812"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00048288"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:41180"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00048288"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"1-hexadecanoyl-2-glutaroyl-sn-glycero-3-phosphocholine + H2O = glutarate + 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:41159"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:30921"},{"database":"ChEBI","id":"CHEBI:72998"},{"database":"ChEBI","id":"CHEBI:77756"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00048471"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:41160"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00048471"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"1-hexadecanoyl-2-nonadioyl-sn-glycero-3-phosphocholine + H2O = nonanedioate + 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:41388"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:72998"},{"database":"ChEBI","id":"CHEBI:78207"},{"database":"ChEBI","id":"CHEBI:78208"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00052808"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:41389"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00052808"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"1-octadecanoyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = 1-octadecanoyl-sn-glycero-3-phosphocholine + acetate + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:54408"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:30089"},{"database":"ChEBI","id":"CHEBI:73858"},{"database":"ChEBI","id":"CHEBI:75220"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00052087"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:54409"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00052087"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"1-octadecanoyl-2-hexanoyl-sn-glycero-3-phosphocholine + H2O = hexanoate + 1-octadecanoyl-sn-glycero-3-phosphocholine + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:54464"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:17120"},{"database":"ChEBI","id":"CHEBI:73858"},{"database":"ChEBI","id":"CHEBI:138212"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00052588"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:54465"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00052588"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"1-octadecanoyl-2-nonanoyl-sn-glycero-3-phosphocholine + H2O = nonanoate + 1-octadecanoyl-sn-glycero-3-phosphocholine + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:54472"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:32361"},{"database":"ChEBI","id":"CHEBI:73858"},{"database":"ChEBI","id":"CHEBI:138214"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00050182"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:54473"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00050182"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"1-octadecanoyl-2-octanoyl-sn-glycero-3-phosphocholine + H2O = 1-octadecanoyl-sn-glycero-3-phosphocholine + octanoate + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:54468"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:25646"},{"database":"ChEBI","id":"CHEBI:73858"},{"database":"ChEBI","id":"CHEBI:138213"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00052747"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:54469"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00052747"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"1-octadecanoyl-2-pentanoyl-sn-glycero-3-phosphocholine + H2O = pentanoate + 1-octadecanoyl-sn-glycero-3-phosphocholine + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:54460"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:31011"},{"database":"ChEBI","id":"CHEBI:73858"},{"database":"ChEBI","id":"CHEBI:138211"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00050674"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:54461"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00050674"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"1-tetradecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + H2O = 2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + tetradecanoate + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:54400"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:30807"},{"database":"ChEBI","id":"CHEBI:76085"},{"database":"ChEBI","id":"CHEBI:86162"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00050195"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:54401"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00050195"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"1-tetradecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O = 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + tetradecanoate + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:54396"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:30807"},{"database":"ChEBI","id":"CHEBI:76079"},{"database":"ChEBI","id":"CHEBI:86102"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00051164"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:54397"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00051164"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"1-tetradecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + H2O = 1-tetradecanoyl-sn-glycero-3-phosphocholine + (9Z,12Z)-octadecadienoate + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:54392"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:30245"},{"database":"ChEBI","id":"CHEBI:64489"},{"database":"ChEBI","id":"CHEBI:86094"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00051705"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:54393"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00051705"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"1-tetradecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + H2O = 2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + tetradecanoate + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:54388"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:30807"},{"database":"ChEBI","id":"CHEBI:76084"},{"database":"ChEBI","id":"CHEBI:86094"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00052144"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:54389"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00052144"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1-acyl-sn-glycero-3-phosphocholine + a fatty acid + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:15801"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:28868"},{"database":"ChEBI","id":"CHEBI:57643"},{"database":"ChEBI","id":"CHEBI:58168"}],"ecNumber":"3.1.1.4","evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023422"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:15802"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023422"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 2-acyl-sn-glycero-3-phosphocholine + a fatty acid + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:18689"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:28868"},{"database":"ChEBI","id":"CHEBI:57643"},{"database":"ChEBI","id":"CHEBI:57875"}],"ecNumber":"3.1.1.32","evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00036688"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:18690"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00036688"}]}]},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004606"}],"value":"Membrane","id":"SL-0162"},"topology":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004606"}],"value":"Single-pass type II membrane protein","id":"SL-9906"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00010884"}],"value":"Belongs to the AB hydrolase superfamily. AB hydrolase 4 family"}],"commentType":"SIMILARITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"NXE19108.1"}],"value":"The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data"}],"commentType":"CAUTION"}],"features":[{"type":"Domain","location":{"start":{"value":137,"modifier":"EXACT"},"end":{"value":378,"modifier":"EXACT"}},"description":"AB hydrolase-1","evidences":[{"evidenceCode":"ECO:0000259","source":"Pfam","id":"PF00561"}]},{"type":"Active site","location":{"start":{"value":217,"modifier":"EXACT"},"end":{"value":217,"modifier":"EXACT"}},"description":"Charge relay system","evidences":[{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR005211-1"}]},{"type":"Active site","location":{"start":{"value":343,"modifier":"EXACT"},"end":{"value":343,"modifier":"EXACT"}},"description":"Charge relay system","evidences":[{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR005211-1"}]},{"type":"Active site","location":{"start":{"value":372,"modifier":"EXACT"},"end":{"value":372,"modifier":"EXACT"}},"description":"Charge relay system","evidences":[{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR005211-1"}]},{"type":"Non-terminal residue","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":1,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"NXE19108.1"}]},{"type":"Non-terminal residue","location":{"start":{"value":408,"modifier":"EXACT"},"end":{"value":408,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"NXE19108.1"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022801"}],"id":"KW-0378","category":"Molecular function","name":"Hydrolase"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023098"}],"id":"KW-0443","category":"Biological process","name":"Lipid metabolism"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023136"}],"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023264"}],"id":"KW-1208","category":"Biological process","name":"Phospholipid metabolism"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000560386"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022487"}],"id":"KW-0719","category":"Molecular function","name":"Serine esterase"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022968"}],"id":"KW-0735","category":"Domain","name":"Signal-anchor"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022692"}],"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022989"}],"id":"KW-1133","category":"Domain","name":"Transmembrane helix"}],"references":[{"referenceNumber":1,"citation":{"id":"CI-90S2KOISV381S","citationType":"submission","authors":["Zhang G."],"title":"Bird 10,000 Genomes (B10K) Project - Family phase.","publicationDate":"SEP-2019","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"NXE19108.1"}],"value":"B10K-CU-031-01","type":"STRAIN"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"NXE19108.1"}],"value":"Muscle","type":"TISSUE"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"NXE19108.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000560386"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"VWPR01000063","properties":[{"key":"ProteinId","value":"NXE19108.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"AlphaFoldDB","id":"A0A7K8KPX5","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000560386","properties":[{"key":"Component","value":"Unassembled WGS sequence"}]},{"database":"GO","id":"GO:0016020","properties":[{"key":"GoTerm","value":"C:membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0004623","properties":[{"key":"GoTerm","value":"F:A2-type glycerophospholipase activity"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-EC"}]},{"database":"GO","id":"GO:0008126","properties":[{"key":"GoTerm","value":"F:acetylesterase activity"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:0008970","properties":[{"key":"GoTerm","value":"F:glycerophospholipid phospholipase A1 activity"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-EC"}]},{"database":"GO","id":"GO:0047372","properties":[{"key":"GoTerm","value":"F:monoacylglycerol lipase activity"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:0051792","properties":[{"key":"GoTerm","value":"P:medium-chain fatty acid biosynthetic process"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:0051793","properties":[{"key":"GoTerm","value":"P:medium-chain fatty acid catabolic process"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:0046470","properties":[{"key":"GoTerm","value":"P:phosphatidylcholine metabolic process"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"FunFam","id":"3.40.50.1820:FF:000079","properties":[{"key":"EntryName","value":"Abhydrolase domain-containing 3"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.40.50.1820","properties":[{"key":"EntryName","value":"alpha/beta hydrolase"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR000073","properties":[{"key":"EntryName","value":"AB_hydrolase_1"}]},{"database":"InterPro","id":"IPR000952","properties":[{"key":"EntryName","value":"AB_hydrolase_4_CS"}]},{"database":"InterPro","id":"IPR050960","properties":[{"key":"EntryName","value":"AB_hydrolase_4_sf"}]},{"database":"InterPro","id":"IPR029058","properties":[{"key":"EntryName","value":"AB_hydrolase_fold"}]},{"database":"InterPro","id":"IPR012020","properties":[{"key":"EntryName","value":"ABHD4"}]},{"database":"PANTHER","id":"PTHR10794","properties":[{"key":"EntryName","value":"ABHYDROLASE DOMAIN-CONTAINING PROTEIN"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR10794:SF50","properties":[{"key":"EntryName","value":"PHOSPHOLIPASE ABHD3"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00561","properties":[{"key":"EntryName","value":"Abhydrolase_1"},{"key":"MatchStatus","value":"1"}]},{"database":"PIRSF","id":"PIRSF005211","properties":[{"key":"EntryName","value":"Ab_hydro_YheT"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF53474","properties":[{"key":"EntryName","value":"alpha/beta-Hydrolases"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS01133","properties":[{"key":"EntryName","value":"UPF0017"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"GAMDWQVLTRELSLYLESQVRVGLFGSGVGLSLVLGFGVAYACYYLSSIAKKPQLVASNDRFCRFLEEYCPVVTETYYPTIWCWEGRVQTLLRPFITSRPQVQYRNELIKTADGGQISLDWFDNNDSLYYPDASTRPTVLLLPGLTGTSKESYILHMIHQSETLGYRCVVFNNRGIAGEDLLTPRTYCAANTEDLEAVVHHVHSLHPSAPFMAAGVSMGGMLLLNYLGKTGRDTPLMAAAIFSAGWNVFESVESLEKPLNWLLFNYYLTTCLQSSISRHRQILEKLFDMDLVMKARTIREFDKRFTSVMFGYPTIDDYYEDASPCRKLKSVGIPVLCLNSVDDVFSPGHAIPVETAKQNANVALVLTSCGGHIGFLEGIWPRKCTYMDRVFKQFVQAMFEHGNKIFSM","length":408,"molWeight":45966,"crc64":"58FB733F15E5C984","md5":"8CC9D057DBBA87F5E53549DFDBEEEFFC"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"CATALYTIC ACTIVITY":19,"SUBCELLULAR LOCATION":1,"SIMILARITY":1,"CAUTION":1},"countByFeatureType":{"Domain":1,"Active site":3,"Non-terminal residue":2},"uniParcId":"UPI0017B1AC7C"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0A7K8KQN9","uniProtkbId":"A0A7K8KQN9_9AVES","entryAudit":{"firstPublicDate":"2021-04-07","lastAnnotationUpdateDate":"2026-11-04","lastSequenceUpdateDate":"2021-04-07","entryVersion":23,"sequenceVersion":1},"annotationScore":5.0,"organism":{"scientificName":"Ardeotis kori","taxonId":89386,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"NXE19376.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000560386"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Archelosauria","Archosauria","Dinosauria","Saurischia","Theropoda","Coelurosauria","Aves","Neognathae","Neoaves","Otidimorphae","Otidiformes","Otididae","Ardeotis"]},"proteinExistence":"3: Inferred from homology","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00041093"}],"value":"Solute carrier family 15 member 1"}},"alternativeNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00043099"}],"value":"Intestinal H(+)/peptide cotransporter"}},{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00041329"}],"value":"Oligopeptide transporter, small intestine isoform"}},{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00042837"}],"value":"Peptide transporter 1"}}],"flag":"Fragment"},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"NXE19376.1"}],"value":"Slc15a1"},"orfNames":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"NXE19376.1"}],"value":"ARDKOR_R01876"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00045775"}],"value":"Electrogenic proton-coupled amino-acid transporter that transports oligopeptides of 2 to 4 amino acids with a preference for dipeptides. Transports neutral and monovalently charged peptides with a proton to peptide stoichiometry of 1:1 or 2:1. Primarily responsible for the absorption of dietary di- and tripeptides from the small intestinal lumen. Mediates transepithelial transport of muramyl and N-formylated bacterial dipeptides contributing to recognition of pathogenic bacteria by the mucosal immune system"}],"commentType":"FUNCTION"},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"L-alanyl-L-aspartate(out) + 2 H(+)(out) = L-alanyl-L-aspartate(in) + 2 H(+)(in)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:71695"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:74363"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00052370"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:71696"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00052370"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"L-alanyl-L-leucyl-L-alanine(out) + H(+)(out) = L-alanyl-L-leucyl-L-alanine(in) + H(+)(in)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:71723"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:191212"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00052590"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:71724"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00052590"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"L-alanyl-L-lysine(out) + H(+)(out) = L-alanyl-L-lysine(in) + H(+)(in)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:72611"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:192470"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00051565"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:72612"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00051565"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"L-alanyl-L-proline(out) + H(+)(out) = L-alanyl-L-proline(in) + H(+)(in)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:64420"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:155848"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00050347"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:64421"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00050347"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"L-alanyl-L-prolylglycine(out) + H(+)(out) = L-alanyl-L-prolylglycine(in) + H(+)(in)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:64432"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:155849"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00051580"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:64433"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00051580"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"L-alanyl-L-valine(out) + H(+)(out) = L-alanyl-L-valine(in) + H(+)(in)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:72615"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:192471"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00050390"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:72616"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00050390"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"L-aspartyl-glycine(out) + 2 H(+)(out) = L-aspartyl-glycine(in) + 2 H(+)(in)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:71683"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:191203"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00050357"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:71684"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00050357"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"L-leucyl-L-leucine(out) + H(+)(out) = L-leucyl-L-leucine(in) + H(+)(in)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:71715"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:191208"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00052105"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:71716"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00052105"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"L-leucyl-L-proline(out) + H(+)(out) = L-leucyl-L-proline(in) + H(+)(in)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:64424"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:155847"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00052153"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:64425"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00052153"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"L-lysyl-glycine(out) + H(+)(out) = L-lysyl-glycine(in) + H(+)(in)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:71679"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:191202"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00050377"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:71680"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00050377"}]},{"directionType":"right-to-left","reactionCrossReference":{"database":"Rhea","id":"RHEA:71681"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00050377"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"L-methionyl-L-phenylalanyl-L-methionine(out) + H(+)(out) = L-methionyl-L-phenylalanyl-L-methionine(in) + H(+)(in)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:71719"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:191211"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00052549"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:71720"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00052549"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"L-phenylalanyl-L-leucine(out) + H(+)(out) = L-phenylalanyl-L-leucine(in) + H(+)(in)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:71699"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:190710"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00051459"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:71700"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00051459"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"L-phenylalanyl-L-phenylalanine(out) + H(+)(out) = L-phenylalanyl-L-phenylalanine(in) + H(+)(in)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:71707"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:191205"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00051804"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:71708"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00051804"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"L-tyrosylglycine(out) + H(+)(out) = L-tyrosylglycine(in) + H(+)(in)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:71711"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:191210"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00051307"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:71712"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00051307"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"N(alpha)-formyl-L-methionyl-L-leucyl-L-phenylalanine(out) + 2 H(+)(out) = N(alpha)-formyl-L-methionyl-L-leucyl-L-phenylalanine(in) + 2 H(+)(in)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:75399"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:194314"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00052040"}]}},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"N-acetyl-D-muramoyl-L-alanyl-D-isoglutamine(out) + 2 H(+)(out) = N-acetyl-D-muramoyl-L-alanyl-D-isoglutamine(in) + 2 H(+)(in)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:64408"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:155830"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00050915"}]}},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"a dipeptide(out) + H(+)(out) = a dipeptide(in) + H(+)(in)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:64392"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:90799"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023522"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:64393"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023522"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"an L-amino acid tripeptide(out) + H(+)(out) = an L-amino acid tripeptide(in) + H(+)(in)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:64400"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:155837"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00036857"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:64401"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00036857"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"carnosine(out) + H(+)(out) = carnosine(in) + H(+)(in)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:64404"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:57485"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00034998"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:64405"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00034998"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"glycyl-L-aspartate(out) + 2 H(+)(out) = glycyl-L-aspartate(in) + 2 H(+)(in)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:71687"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:191204"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00036347"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:71688"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00036347"}]},{"directionType":"right-to-left","reactionCrossReference":{"database":"Rhea","id":"RHEA:71689"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00036347"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"glycyl-L-glutamate(out) + 2 H(+)(out) = glycyl-L-glutamate(in) + 2 H(+)(in)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:71691"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:73784"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00036064"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:71692"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00036064"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"glycyl-L-glutamine(out) + H(+)(out) = glycyl-L-glutamine(in) + H(+)(in)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:71671"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:74392"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00036681"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:71672"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00036681"}]},{"directionType":"right-to-left","reactionCrossReference":{"database":"Rhea","id":"RHEA:71673"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00036681"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"glycyl-L-leucine(out) + H(+)(out) = glycyl-L-leucine(in) + H(+)(in)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:71675"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:143163"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00035846"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:71676"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00035846"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"glycyl-L-proline(out) + H(+)(out) = glycyl-L-proline(in) + H(+)(in)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:64428"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:73779"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00036515"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:64429"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00036515"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"glycyl-sarcosine(out) + H(+)(out) = glycyl-sarcosine(in) + H(+)(in)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:64396"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:155838"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023494"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:64397"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023494"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"glycylglycyl-L-isoleucine(out) + H(+)(out) = glycylglycyl-L-isoleucine(in) + H(+)(in)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:64436"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:155850"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00036905"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:64437"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00036905"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"glycylglycyl-L-proline(out) + H(+)(out) = glycylglycyl-L-proline(in) + H(+)(in)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:64440"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:155851"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00036337"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:64441"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00036337"}]}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023617"}],"value":"Interacts (via extracellular domain region) with trypsin"}],"commentType":"SUBUNIT"},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004424"}],"value":"Apical cell membrane","id":"SL-0015"},"topology":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004424"}],"value":"Multi-pass membrane protein","id":"SL-9909"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003755"}],"value":"Membrane","id":"SL-0162"},"topology":{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003755"}],"value":"Multi-pass membrane protein","id":"SL-9909"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00005982"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003755"}],"value":"Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family"}],"commentType":"SIMILARITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"NXE19376.1"}],"value":"The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data"}],"commentType":"CAUTION"}],"features":[{"type":"Transmembrane","location":{"start":{"value":34,"modifier":"EXACT"},"end":{"value":51,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":57,"modifier":"EXACT"},"end":{"value":80,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":87,"modifier":"EXACT"},"end":{"value":104,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":124,"modifier":"EXACT"},"end":{"value":145,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":166,"modifier":"EXACT"},"end":{"value":186,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":206,"modifier":"EXACT"},"end":{"value":225,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":285,"modifier":"EXACT"},"end":{"value":303,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":334,"modifier":"EXACT"},"end":{"value":354,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":366,"modifier":"EXACT"},"end":{"value":386,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":622,"modifier":"EXACT"},"end":{"value":643,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":655,"modifier":"EXACT"},"end":{"value":676,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Non-terminal residue","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":1,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"NXE19376.1"}]},{"type":"Non-terminal residue","location":{"start":{"value":712,"modifier":"EXACT"},"end":{"value":712,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"NXE19376.1"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022475"}],"id":"KW-1003","category":"Cellular component","name":"Cell membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023180"}],"id":"KW-0325","category":"PTM","name":"Glycoprotein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023136"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022856"}],"id":"KW-0571","category":"Biological process","name":"Peptide transport"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022927"}],"id":"KW-0653","category":"Biological process","name":"Protein transport"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000560386"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022847"}],"id":"KW-0769","category":"Biological process","name":"Symport"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022692"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003755"}],"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022989"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-1133","category":"Domain","name":"Transmembrane helix"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022448"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003755"}],"id":"KW-0813","category":"Biological process","name":"Transport"}],"references":[{"referenceNumber":1,"citation":{"id":"CI-90S2KOISV381S","citationType":"submission","authors":["Zhang G."],"title":"Bird 10,000 Genomes (B10K) Project - Family phase.","publicationDate":"SEP-2019","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"NXE19376.1"}],"value":"B10K-CU-031-01","type":"STRAIN"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"NXE19376.1"}],"value":"Muscle","type":"TISSUE"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"NXE19376.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000560386"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"VWPR01000073","properties":[{"key":"ProteinId","value":"NXE19376.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"AlphaFoldDB","id":"A0A7K8KQN9","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000560386","properties":[{"key":"Component","value":"Unassembled WGS sequence"}]},{"database":"GO","id":"GO:0016324","properties":[{"key":"GoTerm","value":"C:apical plasma membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0035673","properties":[{"key":"GoTerm","value":"F:oligopeptide transmembrane transporter activity"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"CDD","id":"cd17412","properties":[{"key":"EntryName","value":"MFS_SLC15A1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.1250.20:FF:000049","properties":[{"key":"EntryName","value":"Solute carrier family 15 member 2"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.1250.20:FF:000205","properties":[{"key":"EntryName","value":"Solute carrier family 15 oligopeptide transporter member 1"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.20.1250.20","properties":[{"key":"EntryName","value":"MFS general substrate transporter like domains"},{"key":"MatchStatus","value":"2"}]},{"database":"InterPro","id":"IPR036259","properties":[{"key":"EntryName","value":"MFS_trans_sf"}]},{"database":"InterPro","id":"IPR004768","properties":[{"key":"EntryName","value":"Oligopep_transport"}]},{"database":"InterPro","id":"IPR000109","properties":[{"key":"EntryName","value":"POT_fam"}]},{"database":"InterPro","id":"IPR018456","properties":[{"key":"EntryName","value":"PTR2_symporter_CS"}]},{"database":"NCBIfam","id":"TIGR00926","properties":[{"key":"EntryName","value":"2A1704"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR11654","properties":[{"key":"EntryName","value":"OLIGOPEPTIDE TRANSPORTER-RELATED"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00854","properties":[{"key":"EntryName","value":"PTR2"},{"key":"MatchStatus","value":"2"}]},{"database":"SUPFAM","id":"SSF103473","properties":[{"key":"EntryName","value":"MFS general substrate transporter"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS01022","properties":[{"key":"EntryName","value":"PTR2_1"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS01023","properties":[{"key":"EntryName","value":"PTR2_2"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"LSGLTLSVSCLQPNCFGYPLSIFFIVINEFCERFSYYGMRAVLVLYFKYFLQWDDNLSTAIYHTFVALCYLTPILGALIADSWLGKFKTIVSLSIVYTIGQAVMSVSSINDLTDHNRDGLPDNVSLHIGLSMVGLILIALGTGGIKPCVSAFGGDQFEDDQEKQRSRFFSIFYLSINAGSLISTIITPILRAQECGIHSKQRCYPLAFGVPAALMAVSLVVFIVGSRMYKKVQPQGNIMIQVAKCIGFAIKNRFRHRSKEFPKREHWLDWASEKYDKRLIAQTKMVLKVLFLYIPLPMFWALFDQQGSRWTLQATTMDGDFGAFPIQPDQMQTVNPILIIVMVPVVDAVIYPLIKKCKINFTPLRRITVGMFLASLAFVAAALVQVQIDKTLPVFPAAGQSQIKIINLGTDGATVQFEPQLQNVTVTSMASTNYMTFETSGLQSLKITSGNNTTTEVIQLPGGNRHTLEIKNTATGIFSELLFDNVTSKPEEGNNLIRFINNSPDAANVTMGGTSFGTLTSLSATDYSLFSGGRKDNITVIRNSVACSVTSKSLGFGSAYTIVINECSGKILDVTYSEDIPPNTVHMAWQIPQYFILTCAEVVFSVTGLEFSYSQAPSNMKAVLQAGWLLTVAVGNIIVLIVAGASKLSEQWAEYVLFAALLLAVCIIFAIMAYFYTYVDPNEIEAQFEEEKKEVKKDQDFYEKEAEADSQM","length":712,"molWeight":78806,"crc64":"80147688559DD548","md5":"5BBCDFA54693B0049E7172443CB015FC"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"CATALYTIC ACTIVITY":27,"SUBUNIT":1,"SUBCELLULAR LOCATION":1,"SIMILARITY":1,"CAUTION":1},"countByFeatureType":{"Transmembrane":11,"Non-terminal residue":2},"uniParcId":"UPI0017EFE8A6"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0A7K8KQV5","uniProtkbId":"A0A7K8KQV5_9AVES","entryAudit":{"firstPublicDate":"2021-04-07","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2021-04-07","entryVersion":19,"sequenceVersion":1},"annotationScore":5.0,"organism":{"scientificName":"Ardeotis kori","taxonId":89386,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"NXE19250.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000560386"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Archelosauria","Archosauria","Dinosauria","Saurischia","Theropoda","Coelurosauria","Aves","Neognathae","Neoaves","Otidimorphae","Otidiformes","Otididae","Ardeotis"]},"proteinExistence":"3: Inferred from homology","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00026142"}],"value":"Acylglycerol kinase, mitochondrial"},"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00012133"}],"value":"2.7.1.107"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00026096"}],"value":"2.7.1.138"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00026098"}],"value":"2.7.1.94"}]},"alternativeNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00030553"}],"value":"Multiple substrate lipid kinase"}}],"flag":"Fragment"},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"NXE19250.1"}],"value":"Agk"},"orfNames":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"NXE19250.1"}],"value":"ARDKOR_R11766"}]}],"comments":[{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"1,2-di-(9Z-octadecenoyl)-sn-glycerol + ATP = 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + ADP + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:40327"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:30616"},{"database":"ChEBI","id":"CHEBI:52333"},{"database":"ChEBI","id":"CHEBI:74546"},{"database":"ChEBI","id":"CHEBI:456216"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023371"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:40328"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023371"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + ATP = 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + ADP + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:43328"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:30616"},{"database":"ChEBI","id":"CHEBI:34071"},{"database":"ChEBI","id":"CHEBI:74938"},{"database":"ChEBI","id":"CHEBI:456216"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00024483"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:43329"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00024483"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"1-(9Z-octadecenoyl)-sn-glycerol + ATP = 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + ADP + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:41079"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:30616"},{"database":"ChEBI","id":"CHEBI:74544"},{"database":"ChEBI","id":"CHEBI:75757"},{"database":"ChEBI","id":"CHEBI:456216"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00024505"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:41080"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00024505"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"1-hexadecanoyl-sn-glycerol + ATP = 1-hexadecanoyl-sn-glycero-3-phosphate + ADP + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:43308"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:30616"},{"database":"ChEBI","id":"CHEBI:57518"},{"database":"ChEBI","id":"CHEBI:75542"},{"database":"ChEBI","id":"CHEBI:456216"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00024636"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:43309"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00024636"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + ATP = 2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + ADP + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:43316"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:30616"},{"database":"ChEBI","id":"CHEBI:52392"},{"database":"ChEBI","id":"CHEBI:78209"},{"database":"ChEBI","id":"CHEBI:456216"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00024556"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:43317"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00024556"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"N-(hexanoyl)sphing-4-enine + ATP = N-hexanoylsphing-4-enine 1-phosphate + ADP + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:43312"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:30616"},{"database":"ChEBI","id":"CHEBI:63867"},{"database":"ChEBI","id":"CHEBI:82959"},{"database":"ChEBI","id":"CHEBI:456216"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00048876"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:43313"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00048876"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"a 1,2-diacyl-sn-glycerol + ATP = a 1,2-diacyl-sn-glycero-3-phosphate + ADP + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:10272"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:17815"},{"database":"ChEBI","id":"CHEBI:30616"},{"database":"ChEBI","id":"CHEBI:58608"},{"database":"ChEBI","id":"CHEBI:456216"}],"ecNumber":"2.7.1.107","evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023411"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:10273"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023411"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"a 1-acyl-sn-glycerol + ATP = a 1-acyl-sn-glycero-3-phosphate + ADP + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:33747"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:30616"},{"database":"ChEBI","id":"CHEBI:57970"},{"database":"ChEBI","id":"CHEBI:64683"},{"database":"ChEBI","id":"CHEBI:456216"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00024512"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:33748"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00024512"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"a 2-acylglycerol + ATP = a 2-acyl-sn-glycerol 3-phosphate + ADP + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:39847"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:17389"},{"database":"ChEBI","id":"CHEBI:30616"},{"database":"ChEBI","id":"CHEBI:64982"},{"database":"ChEBI","id":"CHEBI:456216"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00044480"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:39848"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00044480"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"a monoacylglycerol + ATP = a monoacyl-sn-glycero-3-phosphate + ADP + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:19293"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:17408"},{"database":"ChEBI","id":"CHEBI:30616"},{"database":"ChEBI","id":"CHEBI:77589"},{"database":"ChEBI","id":"CHEBI:456216"}],"ecNumber":"2.7.1.94","evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00048663"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:19294"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00048663"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"an N-acylsphing-4-enine + ATP = an N-acylsphing-4-enine 1-phosphate + ADP + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:17929"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:30616"},{"database":"ChEBI","id":"CHEBI:52639"},{"database":"ChEBI","id":"CHEBI:57674"},{"database":"ChEBI","id":"CHEBI:456216"}],"ecNumber":"2.7.1.138","evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00048034"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:17930"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00048034"}]}]},{"commentType":"COFACTOR","cofactors":[{"name":"Mg(2+)","evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00001946"}],"cofactorCrossReference":{"database":"ChEBI","id":"CHEBI:18420"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00005175"}],"value":"Lipid metabolism; glycerolipid metabolism"}],"commentType":"PATHWAY"},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004637"}],"value":"Mitochondrion inner membrane","id":"SL-0168"},"topology":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004637"}],"value":"Peripheral membrane protein","id":"SL-9903"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004569"}],"value":"Mitochondrion intermembrane space","id":"SL-0169"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00025749"}],"value":"Belongs to the AGK family"}],"commentType":"SIMILARITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00783"}],"value":"Lacks conserved residue(s) required for the propagation of feature annotation"}],"commentType":"CAUTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"NXE19250.1"}],"value":"The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data"}],"commentType":"CAUTION"}],"features":[{"type":"Domain","location":{"start":{"value":58,"modifier":"EXACT"},"end":{"value":206,"modifier":"EXACT"}},"description":"DAGKc","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50146"}]},{"type":"Non-terminal residue","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":1,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"NXE19250.1"}]},{"type":"Non-terminal residue","location":{"start":{"value":428,"modifier":"EXACT"},"end":{"value":428,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"NXE19250.1"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022840"}],"id":"KW-0067","category":"Ligand","name":"ATP-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022777"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00783"}],"id":"KW-0418","category":"Molecular function","name":"Kinase"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023098"}],"id":"KW-0443","category":"Biological process","name":"Lipid metabolism"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023136"}],"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023128"}],"id":"KW-0496","category":"Cellular component","name":"Mitochondrion"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022792"}],"id":"KW-0999","category":"Cellular component","name":"Mitochondrion inner membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022741"}],"id":"KW-0547","category":"Ligand","name":"Nucleotide-binding"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000560386"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022679"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00783"}],"id":"KW-0808","category":"Molecular function","name":"Transferase"}],"references":[{"referenceNumber":1,"citation":{"id":"CI-90S2KOISV381S","citationType":"submission","authors":["Zhang G."],"title":"Bird 10,000 Genomes (B10K) Project - Family phase.","publicationDate":"SEP-2019","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"NXE19250.1"}],"value":"B10K-CU-031-01","type":"STRAIN"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"NXE19250.1"}],"value":"Muscle","type":"TISSUE"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"NXE19250.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000560386"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"VWPR01000068","properties":[{"key":"ProteinId","value":"NXE19250.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"AlphaFoldDB","id":"A0A7K8KQV5","properties":[{"key":"Description","value":"-"}]},{"database":"UniPathway","id":"UPA00230","properties":[{"key":"RectionId","value":"-"}]},{"database":"Proteomes","id":"UP000560386","properties":[{"key":"Component","value":"Unassembled WGS sequence"}]},{"database":"GO","id":"GO:0005743","properties":[{"key":"GoTerm","value":"C:mitochondrial inner membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0005758","properties":[{"key":"GoTerm","value":"C:mitochondrial intermembrane space"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0047620","properties":[{"key":"GoTerm","value":"F:acylglycerol kinase activity"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-EC"}]},{"database":"GO","id":"GO:0004143","properties":[{"key":"GoTerm","value":"F:ATP-dependent diacylglycerol kinase activity"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-EC"}]},{"database":"GO","id":"GO:0001729","properties":[{"key":"GoTerm","value":"F:ceramide kinase activity"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-EC"}]},{"database":"GO","id":"GO:0046513","properties":[{"key":"GoTerm","value":"P:ceramide biosynthetic process"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:0046486","properties":[{"key":"GoTerm","value":"P:glycerolipid metabolic process"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniPathway"}]},{"database":"GO","id":"GO:0046512","properties":[{"key":"GoTerm","value":"P:sphingosine biosynthetic process"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"CDD","id":"cd01653","properties":[{"key":"EntryName","value":"GATase1"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.40.50.10330","properties":[{"key":"EntryName","value":"Probable inorganic polyphosphate/atp-NAD kinase, domain 1"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR045579","properties":[{"key":"EntryName","value":"AGK_C"}]},{"database":"InterPro","id":"IPR017438","properties":[{"key":"EntryName","value":"ATP-NAD_kinase_N"}]},{"database":"InterPro","id":"IPR001206","properties":[{"key":"EntryName","value":"Diacylglycerol_kinase_cat_dom"}]},{"database":"InterPro","id":"IPR050187","properties":[{"key":"EntryName","value":"Lipid_Phosphate_FormReg"}]},{"database":"InterPro","id":"IPR016064","properties":[{"key":"EntryName","value":"NAD/diacylglycerol_kinase_sf"}]},{"database":"PANTHER","id":"PTHR12358:SF31","properties":[{"key":"EntryName","value":"ACYLGLYCEROL KINASE, MITOCHONDRIAL"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR12358","properties":[{"key":"EntryName","value":"SPHINGOSINE KINASE"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF19712","properties":[{"key":"EntryName","value":"AGK_C"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00781","properties":[{"key":"EntryName","value":"DAGK_cat"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00046","properties":[{"key":"EntryName","value":"DAGKc"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF111331","properties":[{"key":"EntryName","value":"NAD kinase/diacylglycerol kinase-like"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50146","properties":[{"key":"EntryName","value":"DAGK"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"AMKVLTTLRNHWKKTTFGVCLLSWGGNWLYGKHCDNLLRRAACQEAQTFGNQLIPSSMPLKKATVFLNPAACKGKARNLFEKNAAPILHLSGLDVTVVKTDYEGQAKKLLELMENTDLIIIAGGDGTVQEVLQELSDANANLLSSCVQAAFSKIPIGFIPLGKTCTLSHTLYPESTNQVQHITNATLAILKGETVPLDVLQIKGEKEQPVFAVTGLRWGCYRDAGVKVSKYWYLGPLKTKAAHFFSTFKEWPQKHQAALTYLGPTERPPEEPEERPSRPPLYVRLYRRLRLYWSPPPKEIPQEVTPEDWEELKLSTVELSIATRNRQLDLTRTEDFMDICIEADAVSKGQFVNRGSQKMRDPHMCPEGSQCIQASRCILQLLEGTEGSFGIDNEEYEAMPVEVKLLPRKLRFFCDPRMREQMLHAAVQ","length":428,"molWeight":48245,"crc64":"ED46816524C2F47B","md5":"0FA43CFC2F5700B740A4F37CE79AEA2B"},"extraAttributes":{"countByCommentType":{"CATALYTIC ACTIVITY":11,"COFACTOR":1,"PATHWAY":1,"SUBCELLULAR LOCATION":1,"SIMILARITY":1,"CAUTION":2},"countByFeatureType":{"Domain":1,"Non-terminal residue":2},"uniParcId":"UPI0017952E9C"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0A7K8KR22","uniProtkbId":"A0A7K8KR22_9AVES","entryAudit":{"firstPublicDate":"2021-04-07","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2021-04-07","entryVersion":20,"sequenceVersion":1},"annotationScore":5.0,"organism":{"scientificName":"Ardeotis kori","taxonId":89386,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"NXE18862.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000560386"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Archelosauria","Archosauria","Dinosauria","Saurischia","Theropoda","Coelurosauria","Aves","Neognathae","Neoaves","Otidimorphae","Otidiformes","Otididae","Ardeotis"]},"proteinExistence":"3: Inferred from homology","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00040391"}],"value":"Cytosolic purine 5'-nucleotidase"},"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00038866"}],"value":"2.7.1.77"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00012643"}],"value":"3.1.3.5"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00012894"}],"value":"3.1.3.99"}]},"alternativeNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00042328"}],"value":"Cytosolic nucleoside phosphotransferase 5'N"}}],"flag":"Fragment"},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"NXE18862.1"}],"value":"Nt5c2_0"},"orfNames":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"NXE18862.1"}],"value":"ARDKOR_R13132"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00046009"}],"value":"Broad specificity cytosolic 5'-nucleotidase that catalyzes the dephosphorylation of 6-hydroxypurine nucleoside 5'-monophosphates. In addition, possesses a phosphotransferase activity by which it can transfer a phosphate from a donor nucleoside monophosphate to an acceptor nucleoside, preferably inosine, deoxyinosine and guanosine. Has the highest activities for IMP and GMP followed by dIMP, dGMP and XMP. Could also catalyze the transfer of phosphates from pyrimidine monophosphates but with lower efficiency. Through these activities regulates the purine nucleoside/nucleotide pools within the cell"}],"commentType":"FUNCTION"},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"GMP + H2O = guanosine + phosphate","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:27714"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:16750"},{"database":"ChEBI","id":"CHEBI:43474"},{"database":"ChEBI","id":"CHEBI:58115"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00036695"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:27715"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00036695"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"IMP + H2O = inosine + phosphate","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:27718"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:17596"},{"database":"ChEBI","id":"CHEBI:43474"},{"database":"ChEBI","id":"CHEBI:58053"}],"ecNumber":"3.1.3.99","evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00048127"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:27719"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00048127"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"XMP + H2O = xanthosine + phosphate","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:28530"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:18107"},{"database":"ChEBI","id":"CHEBI:43474"},{"database":"ChEBI","id":"CHEBI:57464"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00047560"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:28531"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00047560"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"a 2'-deoxyribonucleoside + a ribonucleoside 5'-phosphate = a ribonucleoside + a 2'-deoxyribonucleoside 5'-phosphate","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:19961"},{"database":"ChEBI","id":"CHEBI:18254"},{"database":"ChEBI","id":"CHEBI:18274"},{"database":"ChEBI","id":"CHEBI:58043"},{"database":"ChEBI","id":"CHEBI:65317"}],"ecNumber":"2.7.1.77","evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00048156"}]}},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"a ribonucleoside 5'-phosphate + H2O = a ribonucleoside + phosphate","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:12484"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:18254"},{"database":"ChEBI","id":"CHEBI:43474"},{"database":"ChEBI","id":"CHEBI:58043"}],"ecNumber":"3.1.3.5","evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00035871"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:12485"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00035871"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"dGMP + H2O = 2'-deoxyguanosine + phosphate","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:29379"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:17172"},{"database":"ChEBI","id":"CHEBI:43474"},{"database":"ChEBI","id":"CHEBI:57673"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00036911"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:29380"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00036911"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"dGMP + inosine = 2'-deoxyguanosine + IMP","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:69580"},{"database":"ChEBI","id":"CHEBI:17172"},{"database":"ChEBI","id":"CHEBI:17596"},{"database":"ChEBI","id":"CHEBI:57673"},{"database":"ChEBI","id":"CHEBI:58053"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00036593"}]}},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"dIMP + H2O = 2'-deoxyinosine + phosphate","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:29383"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:28997"},{"database":"ChEBI","id":"CHEBI:43474"},{"database":"ChEBI","id":"CHEBI:61194"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00036191"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:29384"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00036191"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"dIMP + inosine = 2'-deoxyinosine + IMP","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:69572"},{"database":"ChEBI","id":"CHEBI:17596"},{"database":"ChEBI","id":"CHEBI:28997"},{"database":"ChEBI","id":"CHEBI:58053"},{"database":"ChEBI","id":"CHEBI:61194"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00036258"}]}},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"inosine + AMP = IMP + adenosine","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:69596"},{"database":"ChEBI","id":"CHEBI:16335"},{"database":"ChEBI","id":"CHEBI:17596"},{"database":"ChEBI","id":"CHEBI:58053"},{"database":"ChEBI","id":"CHEBI:456215"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00048155"}]}},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"inosine + CMP = cytidine + IMP","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:69592"},{"database":"ChEBI","id":"CHEBI:17562"},{"database":"ChEBI","id":"CHEBI:17596"},{"database":"ChEBI","id":"CHEBI:58053"},{"database":"ChEBI","id":"CHEBI:60377"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00048783"}]}},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"inosine + GMP = guanosine + IMP","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:69584"},{"database":"ChEBI","id":"CHEBI:16750"},{"database":"ChEBI","id":"CHEBI:17596"},{"database":"ChEBI","id":"CHEBI:58053"},{"database":"ChEBI","id":"CHEBI:58115"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00048038"}]}},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"inosine + UMP = uridine + IMP","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:69588"},{"database":"ChEBI","id":"CHEBI:16704"},{"database":"ChEBI","id":"CHEBI:17596"},{"database":"ChEBI","id":"CHEBI:57865"},{"database":"ChEBI","id":"CHEBI:58053"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00047396"}]}},{"commentType":"COFACTOR","cofactors":[{"name":"Mg(2+)","evidences":[{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR017434-2"}],"cofactorCrossReference":{"database":"ChEBI","id":"CHEBI:18420"}}],"note":{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR017434-2"}],"value":"Binds 1 Mg(2+) ion per subunit."}]}},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00011881"}],"value":"Homotetramer"}],"commentType":"SUBUNIT"},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004514"}],"value":"Cytoplasm, cytosol","id":"SL-0091"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00009589"}],"value":"Belongs to the 5'(3')-deoxyribonucleotidase family"}],"commentType":"SIMILARITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"NXE18862.1"}],"value":"The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data"}],"commentType":"CAUTION"}],"features":[{"type":"Region","location":{"start":{"value":530,"modifier":"EXACT"},"end":{"value":566,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":550,"modifier":"EXACT"},"end":{"value":566,"modifier":"EXACT"}},"description":"Acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Active site","location":{"start":{"value":52,"modifier":"EXACT"},"end":{"value":52,"modifier":"EXACT"}},"description":"Nucleophile","evidences":[{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR017434-1"}]},{"type":"Active site","location":{"start":{"value":54,"modifier":"EXACT"},"end":{"value":54,"modifier":"EXACT"}},"description":"Proton donor","evidences":[{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR017434-1"}]},{"type":"Binding site","location":{"start":{"value":52,"modifier":"EXACT"},"end":{"value":52,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:18420"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR017434-2"}],"ligand":{"name":"Mg(2+)","id":"ChEBI:CHEBI:18420"}},{"type":"Binding site","location":{"start":{"value":54,"modifier":"EXACT"},"end":{"value":54,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:58115"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR017434-2"}],"ligand":{"name":"GMP","id":"ChEBI:CHEBI:58115"}},{"type":"Binding site","location":{"start":{"value":351,"modifier":"EXACT"},"end":{"value":351,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:18420"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR017434-2"}],"ligand":{"name":"Mg(2+)","id":"ChEBI:CHEBI:18420"}},{"type":"Non-terminal residue","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":1,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"NXE18862.1"}]},{"type":"Non-terminal residue","location":{"start":{"value":566,"modifier":"EXACT"},"end":{"value":566,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"NXE18862.1"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022533"}],"id":"KW-0021","category":"Molecular function","name":"Allosteric enzyme"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022840"}],"id":"KW-0067","category":"Ligand","name":"ATP-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022490"}],"id":"KW-0963","category":"Cellular component","name":"Cytoplasm"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022801"}],"id":"KW-0378","category":"Molecular function","name":"Hydrolase"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022842"},{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR017434-2"}],"id":"KW-0460","category":"Ligand","name":"Magnesium"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022723"},{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR017434-2"}],"id":"KW-0479","category":"Ligand","name":"Metal-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023080"}],"id":"KW-0546","category":"Biological process","name":"Nucleotide metabolism"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022741"}],"id":"KW-0547","category":"Ligand","name":"Nucleotide-binding"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000560386"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022679"}],"id":"KW-0808","category":"Molecular function","name":"Transferase"}],"references":[{"referenceNumber":1,"citation":{"id":"CI-90S2KOISV381S","citationType":"submission","authors":["Zhang G."],"title":"Bird 10,000 Genomes (B10K) Project - Family phase.","publicationDate":"SEP-2019","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"NXE18862.1"}],"value":"B10K-CU-031-01","type":"STRAIN"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"NXE18862.1"}],"value":"Muscle","type":"TISSUE"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"NXE18862.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000560386"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"VWPR01000051","properties":[{"key":"ProteinId","value":"NXE18862.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"AlphaFoldDB","id":"A0A7K8KR22","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000560386","properties":[{"key":"Component","value":"Unassembled WGS sequence"}]},{"database":"GO","id":"GO:0005829","properties":[{"key":"GoTerm","value":"C:cytosol"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0008253","properties":[{"key":"GoTerm","value":"F:5'-nucleotidase activity"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-EC"}]},{"database":"GO","id":"GO:0050146","properties":[{"key":"GoTerm","value":"F:nucleoside phosphotransferase activity"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-EC"}]},{"database":"GO","id":"GO:0046085","properties":[{"key":"GoTerm","value":"P:adenosine metabolic process"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:0046040","properties":[{"key":"GoTerm","value":"P:IMP metabolic process"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"CDD","id":"cd07522","properties":[{"key":"EntryName","value":"HAD_cN-II"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.40.50.1000:FF:000021","properties":[{"key":"EntryName","value":"NT5C2 isoform 1"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.40.50.1000","properties":[{"key":"EntryName","value":"HAD superfamily/HAD-like"},{"key":"MatchStatus","value":"2"}]},{"database":"InterPro","id":"IPR036412","properties":[{"key":"EntryName","value":"HAD-like_sf"}]},{"database":"InterPro","id":"IPR008380","properties":[{"key":"EntryName","value":"HAD-SF_hydro_IG_5-nucl"}]},{"database":"InterPro","id":"IPR023214","properties":[{"key":"EntryName","value":"HAD_sf"}]},{"database":"InterPro","id":"IPR016695","properties":[{"key":"EntryName","value":"Pur_nucleotidase"}]},{"database":"NCBIfam","id":"TIGR02244","properties":[{"key":"EntryName","value":"HAD-IG-Ncltidse"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR12103","properties":[{"key":"EntryName","value":"5'-NUCLEOTIDASE DOMAIN-CONTAINING"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR12103:SF17","properties":[{"key":"EntryName","value":"CYTOSOLIC PURINE 5'-NUCLEOTIDASE"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF05761","properties":[{"key":"EntryName","value":"5_nucleotid"},{"key":"MatchStatus","value":"1"}]},{"database":"PIRSF","id":"PIRSF017434","properties":[{"key":"EntryName","value":"Purine_5'-nucleotidase"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF56784","properties":[{"key":"EntryName","value":"HAD-like"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MTTSWSDRLQNAADLPANMDGHALKKYRREAYHRVFVNRSLAMEKIKCFGFDMDYTLAVYKSPEYESLGFDLTVERLVSIGYPHELLNFVYDPAFPTRGLVFDTHYGNLLKVDAYGNLLVCAHGFNFLRGPETRDQYPNKFIQRDDTDRFYILNTLFNLPETYLLACLVDFFTNCDRYTSCETGFKDGDLFMSFRSMFQDVRDAVDWVHYKGSLKEKTLENLEKYVVKDGKLPLLLSRMNEVGKVFLVTNSDYKYTDKIMTYLFDFPHGPKPGSAHRPWQSYFDLILVDARKPLFFGEGTVLRQVDTVTGKLKIGTYTGPLQHGIVYSGGSSDTVCDLLGAKGKDILYIGDHIFGDILKSKKRQGWRTFLVIPELAQELHVWTDKSALFEELQSLDIFLAELYKHLDSSSNERPDISSIQRRIKKVTHDMDMCYGMMGSLFRSGSRQTLFASQVMRYADLYAASFINLLYYPFSYLFRAAHVLMPHESTVEHTHVDINEKESPMATRNRTSVDFKDSDYKRHHLTRSISEIKPPNLFPQAPQEITHCHDEDDDEEEEEEEEEEEEE","length":566,"molWeight":65546,"crc64":"2625878279FCB7A5","md5":"D564F31E455AB5BBBAB92CB6776EFE6E"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"CATALYTIC ACTIVITY":13,"COFACTOR":1,"SUBUNIT":1,"SUBCELLULAR LOCATION":1,"SIMILARITY":1,"CAUTION":1},"countByFeatureType":{"Region":1,"Compositional bias":1,"Active site":2,"Binding site":3,"Non-terminal residue":2},"uniParcId":"UPI0004FC0117"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0A7K8KRD6","uniProtkbId":"A0A7K8KRD6_9AVES","entryAudit":{"firstPublicDate":"2021-04-07","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2021-04-07","entryVersion":18,"sequenceVersion":1},"annotationScore":5.0,"organism":{"scientificName":"Ardeotis kori","taxonId":89386,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"NXE17955.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000560386"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Archelosauria","Archosauria","Dinosauria","Saurischia","Theropoda","Coelurosauria","Aves","Neognathae","Neoaves","Otidimorphae","Otidiformes","Otididae","Ardeotis"]},"proteinExistence":"3: Inferred from homology","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00068889"}],"value":"GDH/6PGL endoplasmic bifunctional protein"},"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00066973"}],"value":"1.1.1.363"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00024389"}],"value":"1.1.1.47"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00013198"}],"value":"3.1.1.31"}]},"flag":"Fragment"},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"NXE17955.1"}],"value":"H6pd"},"orfNames":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"NXE17955.1"}],"value":"ARDKOR_R05878"}]}],"comments":[{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"2-deoxy-D-glucose 6-phosphate + NAD(+) = 2-deoxy-6-phospho-D-glucono-1,5-lactone + NADH + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:62064"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:57540"},{"database":"ChEBI","id":"CHEBI:57945"},{"database":"ChEBI","id":"CHEBI:84760"},{"database":"ChEBI","id":"CHEBI:145420"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00051041"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:62065"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00051041"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"2-deoxy-D-glucose 6-phosphate + NADP(+) = 2-deoxy-6-phospho-D-glucono-1,5-lactone + NADPH + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:62068"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:57783"},{"database":"ChEBI","id":"CHEBI:58349"},{"database":"ChEBI","id":"CHEBI:84760"},{"database":"ChEBI","id":"CHEBI:145420"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00050329"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:62069"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00050329"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"6-phospho-D-glucono-1,5-lactone + H2O = 6-phospho-D-gluconate + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:12556"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:57955"},{"database":"ChEBI","id":"CHEBI:58759"}],"ecNumber":"3.1.1.31","evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00051910"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:12557"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00051910"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"D-galactose 6-phosphate + NAD(+) = 6-phospho-D-galactono-1,5-lactone + NADH + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:62076"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:57540"},{"database":"ChEBI","id":"CHEBI:57945"},{"database":"ChEBI","id":"CHEBI:91004"},{"database":"ChEBI","id":"CHEBI:145419"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00050197"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:62077"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00050197"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"D-galactose 6-phosphate + NADP(+) = 6-phospho-D-galactono-1,5-lactone + NADPH + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:62072"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:57783"},{"database":"ChEBI","id":"CHEBI:58349"},{"database":"ChEBI","id":"CHEBI:91004"},{"database":"ChEBI","id":"CHEBI:145419"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00052267"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:62073"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00052267"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"D-glucosamine 6-phosphate + NADP(+) = 2-amino-2-deoxy-6-phospho-D-glucono-1,5-lactone + NADPH + 2 H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:62088"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:57783"},{"database":"ChEBI","id":"CHEBI:58349"},{"database":"ChEBI","id":"CHEBI:58725"},{"database":"ChEBI","id":"CHEBI:145423"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00050459"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:62089"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00050459"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"D-glucose + NAD(+) = D-glucono-1,5-lactone + NADH + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:14293"},{"database":"ChEBI","id":"CHEBI:4167"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:16217"},{"database":"ChEBI","id":"CHEBI:57540"},{"database":"ChEBI","id":"CHEBI:57945"}],"ecNumber":"1.1.1.47","evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00051596"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:14294"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00051596"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"D-glucose + NADP(+) = D-glucono-1,5-lactone + NADPH + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:14405"},{"database":"ChEBI","id":"CHEBI:4167"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:16217"},{"database":"ChEBI","id":"CHEBI:57783"},{"database":"ChEBI","id":"CHEBI:58349"}],"ecNumber":"1.1.1.47","evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00050594"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:14406"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00050594"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"D-glucose 6-phosphate + NAD(+) = 6-phospho-D-glucono-1,5-lactone + NADH + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:38215"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:57540"},{"database":"ChEBI","id":"CHEBI:57945"},{"database":"ChEBI","id":"CHEBI:57955"},{"database":"ChEBI","id":"CHEBI:61548"}],"ecNumber":"1.1.1.363","evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00051249"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:38216"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00051249"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"D-glucose 6-phosphate + NADP(+) = 6-phospho-D-glucono-1,5-lactone + NADPH + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:15841"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:57783"},{"database":"ChEBI","id":"CHEBI:57955"},{"database":"ChEBI","id":"CHEBI:58349"},{"database":"ChEBI","id":"CHEBI:61548"}],"ecNumber":"1.1.1.363","evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00051019"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:15842"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00051019"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"D-glucose 6-sulfate + NADP(+) = 6-sulfo-D-glucono-1,5-lactone + NADPH + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:62080"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:57783"},{"database":"ChEBI","id":"CHEBI:58349"},{"database":"ChEBI","id":"CHEBI:145424"},{"database":"ChEBI","id":"CHEBI:145427"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00051107"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:62081"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00051107"}]}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004961"}],"value":"Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 2/3"}],"commentType":"PATHWAY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00061271"}],"value":"In the C-terminal section; belongs to the glucosamine/galactosamine-6-phosphate isomerase family. 6-phosphogluconolactonase subfamily"}],"commentType":"SIMILARITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00061632"}],"value":"In the N-terminal section; belongs to the glucose-6-phosphate dehydrogenase family"}],"commentType":"SIMILARITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"NXE17955.1"}],"value":"The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data"}],"commentType":"CAUTION"}],"features":[{"type":"Signal","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":22,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}]},{"type":"Chain","location":{"start":{"value":23,"modifier":"EXACT"},"end":{"value":791,"modifier":"EXACT"}},"description":"GDH/6PGL endoplasmic bifunctional protein","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"featureId":"PRO_5029600009"},{"type":"Domain","location":{"start":{"value":30,"modifier":"EXACT"},"end":{"value":212,"modifier":"EXACT"}},"description":"Glucose-6-phosphate dehydrogenase NAD-binding","evidences":[{"evidenceCode":"ECO:0000259","source":"Pfam","id":"PF00479"}]},{"type":"Domain","location":{"start":{"value":218,"modifier":"EXACT"},"end":{"value":508,"modifier":"EXACT"}},"description":"Glucose-6-phosphate dehydrogenase C-terminal","evidences":[{"evidenceCode":"ECO:0000259","source":"Pfam","id":"PF02781"}]},{"type":"Domain","location":{"start":{"value":560,"modifier":"EXACT"},"end":{"value":782,"modifier":"EXACT"}},"description":"Glucosamine/galactosamine-6-phosphate isomerase","evidences":[{"evidenceCode":"ECO:0000259","source":"Pfam","id":"PF01182"}]},{"type":"Binding site","location":{"start":{"value":209,"modifier":"EXACT"},"end":{"value":209,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU10005"}],"ligand":{"name":"substrate"}},{"type":"Non-terminal residue","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":1,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"NXE17955.1"}]},{"type":"Non-terminal residue","location":{"start":{"value":791,"modifier":"EXACT"},"end":{"value":791,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"NXE17955.1"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023277"}],"id":"KW-0119","category":"Biological process","name":"Carbohydrate metabolism"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022526"}],"id":"KW-0313","category":"Biological process","name":"Glucose metabolism"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022801"}],"id":"KW-0378","category":"Molecular function","name":"Hydrolase"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022857"}],"id":"KW-0521","category":"Ligand","name":"NADP"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023002"}],"id":"KW-0560","category":"Molecular function","name":"Oxidoreductase"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000560386"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"id":"KW-0732","category":"Domain","name":"Signal"}],"references":[{"referenceNumber":1,"citation":{"id":"CI-90S2KOISV381S","citationType":"submission","authors":["Zhang G."],"title":"Bird 10,000 Genomes (B10K) Project - Family phase.","publicationDate":"SEP-2019","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"NXE17955.1"}],"value":"B10K-CU-031-01","type":"STRAIN"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"NXE17955.1"}],"value":"Muscle","type":"TISSUE"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"NXE17955.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000560386"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"VWPR01000017","properties":[{"key":"ProteinId","value":"NXE17955.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"AlphaFoldDB","id":"A0A7K8KRD6","properties":[{"key":"Description","value":"-"}]},{"database":"UniPathway","id":"UPA00115","properties":[{"key":"RectionId","value":"-"}]},{"database":"Proteomes","id":"UP000560386","properties":[{"key":"Component","value":"Unassembled WGS sequence"}]},{"database":"GO","id":"GO:0005783","properties":[{"key":"GoTerm","value":"C:endoplasmic reticulum"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:0017057","properties":[{"key":"GoTerm","value":"F:6-phosphogluconolactonase activity"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-EC"}]},{"database":"GO","id":"GO:0047936","properties":[{"key":"GoTerm","value":"F:glucose 1-dehydrogenase [NAD(P)+] activity"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-EC"}]},{"database":"GO","id":"GO:0004345","properties":[{"key":"GoTerm","value":"F:glucose-6-phosphate dehydrogenase activity"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0050661","properties":[{"key":"GoTerm","value":"F:NADP binding"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0006006","properties":[{"key":"GoTerm","value":"P:glucose metabolic process"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0009051","properties":[{"key":"GoTerm","value":"P:pentose-phosphate shunt, oxidative branch"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"CDD","id":"cd01400","properties":[{"key":"EntryName","value":"6PGL"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.40.50.1360:FF:000015","properties":[{"key":"EntryName","value":"Hexose-6-phosphate dehydrogenase/glucose 1-dehydrogenase"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.40.50.1360","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.30.360.10","properties":[{"key":"EntryName","value":"Dihydrodipicolinate Reductase, domain 2"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.40.50.720","properties":[{"key":"EntryName","value":"NAD(P)-binding Rossmann-like Domain"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR005900","properties":[{"key":"EntryName","value":"6-phosphogluconolactonase_DevB"}]},{"database":"InterPro","id":"IPR001282","properties":[{"key":"EntryName","value":"G6P_DH"}]},{"database":"InterPro","id":"IPR019796","properties":[{"key":"EntryName","value":"G6P_DH_AS"}]},{"database":"InterPro","id":"IPR022675","properties":[{"key":"EntryName","value":"G6P_DH_C"}]},{"database":"InterPro","id":"IPR022674","properties":[{"key":"EntryName","value":"G6P_DH_NAD-bd"}]},{"database":"InterPro","id":"IPR006148","properties":[{"key":"EntryName","value":"Glc/Gal-6P_isomerase"}]},{"database":"InterPro","id":"IPR036291","properties":[{"key":"EntryName","value":"NAD(P)-bd_dom_sf"}]},{"database":"InterPro","id":"IPR037171","properties":[{"key":"EntryName","value":"NagB/RpiA_transferase-like"}]},{"database":"NCBIfam","id":"TIGR01198","properties":[{"key":"EntryName","value":"pgl"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR23429:SF7","properties":[{"key":"EntryName","value":"GDH_6PGL ENDOPLASMIC BIFUNCTIONAL PROTEIN"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR23429","properties":[{"key":"EntryName","value":"GLUCOSE-6-PHOSPHATE 1-DEHYDROGENASE G6PD"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF02781","properties":[{"key":"EntryName","value":"G6PD_C"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00479","properties":[{"key":"EntryName","value":"G6PD_N"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF01182","properties":[{"key":"EntryName","value":"Glucosamine_iso"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR00079","properties":[{"key":"EntryName","value":"G6PDHDRGNASE"}]},{"database":"SUPFAM","id":"SSF55347","properties":[{"key":"EntryName","value":"Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF51735","properties":[{"key":"EntryName","value":"NAD(P)-binding Rossmann-fold domains"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF100950","properties":[{"key":"EntryName","value":"NagB/RpiA/CoA transferase-like"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00069","properties":[{"key":"EntryName","value":"G6P_DEHYDROGENASE"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"KMLGRVLCTVVFMGALPSLVEVSQGHISVVLLGATGDLAKKYLWQGLFELYMDQVSSGHSFTFHGAALTALEPGQRLMFDVLKKLACPPDESPNRCAVLKDQFLKLSQYHQLKTAENYTALNREIETLLRQEGLQEAGRIFYFSVPPFAYTEIARHINSSCRPPPGAWLRVVLEKPFGHDLESAQQLAAELASFFREEEMYRVDHYLGKQAVAHILPFRDQNRQFLDAIWNRHHVERVEIVLKETVDAKGRTSFYEQYGVIRDVLQNHLTEALMFLTMELPANVSRAEEVLQCKLQAFQSLRGLEKRSAVLGQYQAYASQVQEELQKAQDYISTTPTFAGVLIHSDSLRWEGVPFLLTSGKALDERVGYIRVLFKNRAYCTQRETLRDAGYSQCKAKQIIFYIGHGALNTPAVLVSRNLFRPIMPEGSWREAVGQSDLYIFGQPLSDYYVYNPVKERDAYSILISNIYHGRKDFFITTENLLASWRFWTPLLNSVSHQPLRLYPGGVENQHLLDFEMVSGEVVFTLAEPVELLNPNRLMPSDYRTIQSKFRESPLVSAWSEDLISQLASDIEKTASRTVAHSGQFHLALSGGSSPVVLFQRLARHHYAFPWRHTHIWLVDERCVPLTDTESNFFSLHNHLLQSVRVPYFNVHPMPVHLNQRLCVEEDRGTEMYAKEIVALVANASFDLVLLGVGTDGHTASLFPESENGLEGAQTVVLTESPVKPHQRMSLSLPLINRARQVFVLVLGKGKHDITTLLSRVGHQPRKWPVSGVSPSSGQLVWYVDYEALLG","length":791,"molWeight":89627,"crc64":"B8572FDCC881E68C","md5":"F520462D5A1B96A223EFFCC8358EC527"},"extraAttributes":{"countByCommentType":{"CATALYTIC ACTIVITY":11,"PATHWAY":1,"SIMILARITY":2,"CAUTION":1},"countByFeatureType":{"Signal":1,"Chain":1,"Domain":3,"Binding site":1,"Non-terminal residue":2},"uniParcId":"UPI0018344E23"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0A7K8KRL6","uniProtkbId":"A0A7K8KRL6_9AVES","entryAudit":{"firstPublicDate":"2021-04-07","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2021-04-07","entryVersion":19,"sequenceVersion":1},"annotationScore":5.0,"organism":{"scientificName":"Ardeotis kori","taxonId":89386,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"NXE19737.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000560386"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Archelosauria","Archosauria","Dinosauria","Saurischia","Theropoda","Coelurosauria","Aves","Neognathae","Neoaves","Otidimorphae","Otidiformes","Otididae","Ardeotis"]},"proteinExistence":"3: Inferred from homology","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00073945"}],"value":"Complex I assembly factor ACAD9, mitochondrial"},"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00012033"}],"value":"1.3.8.7"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00012040"}],"value":"1.3.8.8"}]},"alternativeNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00076025"}],"value":"Acyl-CoA dehydrogenase family member 9"}}],"flag":"Fragment"},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"NXE19737.1"}],"value":"Acad9"},"orfNames":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"NXE19737.1"}],"value":"ARDKOR_R01491"}]}],"comments":[{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"(11Z)-eicosenoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E,11Z)-eicosadienoyl-CoA + reduced [electron-transfer flavoprotein]","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:83055"},{"database":"Rhea","id":"RHEA-COMP:10685"},{"database":"Rhea","id":"RHEA-COMP:10686"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:57692"},{"database":"ChEBI","id":"CHEBI:58307"},{"database":"ChEBI","id":"CHEBI:74069"},{"database":"ChEBI","id":"CHEBI:76388"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00095658"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:83056"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00095658"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"(11Z)-octadecenoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E,11Z)-octadecadienoyl-CoA + reduced [electron-transfer flavoprotein]","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:83023"},{"database":"Rhea","id":"RHEA-COMP:10685"},{"database":"Rhea","id":"RHEA-COMP:10686"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:57692"},{"database":"ChEBI","id":"CHEBI:58307"},{"database":"ChEBI","id":"CHEBI:75121"},{"database":"ChEBI","id":"CHEBI:76558"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00095584"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:83024"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00095584"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"(4Z)-decenoyl-CoA(4-) + oxidized [electron-transfer flavoprotein] + H(+) = (2E,4Z)-decadienoyl-CoA + reduced [electron-transfer flavoprotein]","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:84475"},{"database":"Rhea","id":"RHEA-COMP:10685"},{"database":"Rhea","id":"RHEA-COMP:10686"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:57692"},{"database":"ChEBI","id":"CHEBI:58307"},{"database":"ChEBI","id":"CHEBI:137593"},{"database":"ChEBI","id":"CHEBI:233838"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00095446"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:84476"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00095446"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"(4Z)-hexadecenoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E,4Z)-hexadecadienoyl-CoA + reduced [electron-transfer flavoprotein]","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:83223"},{"database":"Rhea","id":"RHEA-COMP:10685"},{"database":"Rhea","id":"RHEA-COMP:10686"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:57692"},{"database":"ChEBI","id":"CHEBI:58307"},{"database":"ChEBI","id":"CHEBI:232775"},{"database":"ChEBI","id":"CHEBI:232776"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00095427"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:83224"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00095427"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"(4Z)-tetradecenoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E,4Z)-tetradecadienoyl-CoA + reduced [electron-transfer flavoprotein]","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:83159"},{"database":"Rhea","id":"RHEA-COMP:10685"},{"database":"Rhea","id":"RHEA-COMP:10686"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:57692"},{"database":"ChEBI","id":"CHEBI:58307"},{"database":"ChEBI","id":"CHEBI:232764"},{"database":"ChEBI","id":"CHEBI:232765"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00095510"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:83160"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00095510"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"(4Z,7Z)-decadienoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E,4Z,7Z)-decatrienoyl-CoA + reduced [electron-transfer flavoprotein]","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:84611"},{"database":"Rhea","id":"RHEA-COMP:10685"},{"database":"Rhea","id":"RHEA-COMP:10686"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:57692"},{"database":"ChEBI","id":"CHEBI:58307"},{"database":"ChEBI","id":"CHEBI:233850"},{"database":"ChEBI","id":"CHEBI:233851"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00095565"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:84612"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00095565"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"(4Z,7Z,10Z)-hexadecatrienoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E,4Z,7Z,10Z)-hexadecatetraenoyl-CoA + reduced [electron-transfer flavoprotein]","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:84623"},{"database":"Rhea","id":"RHEA-COMP:10685"},{"database":"Rhea","id":"RHEA-COMP:10686"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:57692"},{"database":"ChEBI","id":"CHEBI:58307"},{"database":"ChEBI","id":"CHEBI:233781"},{"database":"ChEBI","id":"CHEBI:233783"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00095501"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:84624"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00095501"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"(4Z,7Z,10Z,13Z)-hexadecatetraenoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E,4Z,7Z,10Z,13Z)-hexadecapentaenoyl-CoA + reduced [electron-transfer flavoprotein]","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:85123"},{"database":"Rhea","id":"RHEA-COMP:10685"},{"database":"Rhea","id":"RHEA-COMP:10686"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:57692"},{"database":"ChEBI","id":"CHEBI:58307"},{"database":"ChEBI","id":"CHEBI:233765"},{"database":"ChEBI","id":"CHEBI:233790"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00095626"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:85124"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00095626"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"(5Z)-dodecenoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E,5Z)-dodecadienoyl-CoA + reduced [electron-transfer flavoprotein]","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:82951"},{"database":"Rhea","id":"RHEA-COMP:10685"},{"database":"Rhea","id":"RHEA-COMP:10686"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:57692"},{"database":"ChEBI","id":"CHEBI:58307"},{"database":"ChEBI","id":"CHEBI:230464"},{"database":"ChEBI","id":"CHEBI:232684"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00095627"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:82952"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00095627"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"(5Z)-hexadecenoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E,5Z)-hexadecadienoyl-CoA + reduced [electron-transfer flavoprotein]","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:83387"},{"database":"Rhea","id":"RHEA-COMP:10685"},{"database":"Rhea","id":"RHEA-COMP:10686"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:57692"},{"database":"ChEBI","id":"CHEBI:58307"},{"database":"ChEBI","id":"CHEBI:232908"},{"database":"ChEBI","id":"CHEBI:232910"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00095447"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:83388"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00095447"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"(5Z)-tetradecenoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E,5Z)-tetradecadienoyl-CoA + reduced [electron-transfer flavoprotein]","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:47448"},{"database":"Rhea","id":"RHEA-COMP:10685"},{"database":"Rhea","id":"RHEA-COMP:10686"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:57692"},{"database":"ChEBI","id":"CHEBI:58307"},{"database":"ChEBI","id":"CHEBI:84650"},{"database":"ChEBI","id":"CHEBI:87701"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00048187"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:47449"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00048187"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"(5Z,8Z)-tetradecadienoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E,5Z,8Z)-tetradecatrienoyl-CoA + reduced [electron-transfer flavoprotein]","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:84467"},{"database":"Rhea","id":"RHEA-COMP:10685"},{"database":"Rhea","id":"RHEA-COMP:10686"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:57692"},{"database":"ChEBI","id":"CHEBI:58307"},{"database":"ChEBI","id":"CHEBI:233789"},{"database":"ChEBI","id":"CHEBI:233827"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00095729"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:84468"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00095729"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"(5Z,8Z,11Z)-tetradecatrienoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E,5Z,8Z,11Z)-tetradecatetraenoyl-CoA + reduced [electron-transfer flavoprotein]","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:84603"},{"database":"Rhea","id":"RHEA-COMP:10685"},{"database":"Rhea","id":"RHEA-COMP:10686"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:57692"},{"database":"ChEBI","id":"CHEBI:58307"},{"database":"ChEBI","id":"CHEBI:233795"},{"database":"ChEBI","id":"CHEBI:233796"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00095764"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:84604"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00095764"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"(6Z)-dodecenoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E,6Z)-dodecadienoyl-CoA + reduced [electron-transfer flavoprotein]","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:84471"},{"database":"Rhea","id":"RHEA-COMP:10685"},{"database":"Rhea","id":"RHEA-COMP:10686"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:57692"},{"database":"ChEBI","id":"CHEBI:58307"},{"database":"ChEBI","id":"CHEBI:233834"},{"database":"ChEBI","id":"CHEBI:233835"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00095438"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:84472"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00095438"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"(6Z)-hexadecenoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E,6Z)-hexadecadienoyl-CoA + reduced [electron-transfer flavoprotein]","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:83155"},{"database":"Rhea","id":"RHEA-COMP:10685"},{"database":"Rhea","id":"RHEA-COMP:10686"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:57692"},{"database":"ChEBI","id":"CHEBI:58307"},{"database":"ChEBI","id":"CHEBI:74339"},{"database":"ChEBI","id":"CHEBI:232761"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00095629"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:83156"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00095629"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"(6Z)-octadecenoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E,6Z)-octadecadienoyl-CoA + reduced [electron-transfer flavoprotein]","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:83207"},{"database":"Rhea","id":"RHEA-COMP:10685"},{"database":"Rhea","id":"RHEA-COMP:10686"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:57692"},{"database":"ChEBI","id":"CHEBI:58307"},{"database":"ChEBI","id":"CHEBI:75123"},{"database":"ChEBI","id":"CHEBI:232772"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00095603"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:83208"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00095603"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"(6Z,9Z)-dodecadienoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E,6Z,9Z)-dodecatrienoyl-CoA + reduced [electron-transfer flavoprotein]","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:84607"},{"database":"Rhea","id":"RHEA-COMP:10685"},{"database":"Rhea","id":"RHEA-COMP:10686"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:57692"},{"database":"ChEBI","id":"CHEBI:58307"},{"database":"ChEBI","id":"CHEBI:233810"},{"database":"ChEBI","id":"CHEBI:233847"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00095680"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:84608"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00095680"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"(6Z,9Z,12Z)-octadecatrienoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E,6Z,9Z,12Z)-octadecatetraenoyl-CoA + reduced [electron-transfer flavoprotein]","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:84619"},{"database":"Rhea","id":"RHEA-COMP:10685"},{"database":"Rhea","id":"RHEA-COMP:10686"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:57363"},{"database":"ChEBI","id":"CHEBI:57692"},{"database":"ChEBI","id":"CHEBI:58307"},{"database":"ChEBI","id":"CHEBI:233778"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00095487"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:84620"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00095487"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"(6Z,9Z,12Z,15Z)-octadecatetraenoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E,6Z,9Z,12Z,15Z)-octadecapentaenoyl-CoA + reduced [electron-transfer flavoprotein]","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:85107"},{"database":"Rhea","id":"RHEA-COMP:10685"},{"database":"Rhea","id":"RHEA-COMP:10686"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:57692"},{"database":"ChEBI","id":"CHEBI:58307"},{"database":"ChEBI","id":"CHEBI:71489"},{"database":"ChEBI","id":"CHEBI:233740"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00095474"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:85108"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00095474"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"(7Z)-hexadecenoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E,7Z)-hexadecadienoyl-CoA + reduced [electron-transfer flavoprotein]","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:47432"},{"database":"Rhea","id":"RHEA-COMP:10685"},{"database":"Rhea","id":"RHEA-COMP:10686"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:57692"},{"database":"ChEBI","id":"CHEBI:58307"},{"database":"ChEBI","id":"CHEBI:87698"},{"database":"ChEBI","id":"CHEBI:87717"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00095469"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:47433"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00095469"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"(7Z)-octadecenoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E,7Z)-octadecadienoyl-CoA + reduced [electron-transfer flavoprotein]","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:83371"},{"database":"Rhea","id":"RHEA-COMP:10685"},{"database":"Rhea","id":"RHEA-COMP:10686"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:57692"},{"database":"ChEBI","id":"CHEBI:58307"},{"database":"ChEBI","id":"CHEBI:152050"},{"database":"ChEBI","id":"CHEBI:232899"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00095536"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:83372"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00095536"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"(7Z)-tetradecenoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E,7Z)-tetradecadienoyl-CoA + reduced [electron-transfer flavoprotein]","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:82939"},{"database":"Rhea","id":"RHEA-COMP:10685"},{"database":"Rhea","id":"RHEA-COMP:10686"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:57692"},{"database":"ChEBI","id":"CHEBI:58307"},{"database":"ChEBI","id":"CHEBI:232643"},{"database":"ChEBI","id":"CHEBI:232680"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00095631"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:82940"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00095631"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"(7Z,10Z)-hexadecadienoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E,7Z,10Z)-hexadecatrienoyl-CoA + reduced [electron-transfer flavoprotein]","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:84463"},{"database":"Rhea","id":"RHEA-COMP:10685"},{"database":"Rhea","id":"RHEA-COMP:10686"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:57692"},{"database":"ChEBI","id":"CHEBI:58307"},{"database":"ChEBI","id":"CHEBI:233785"},{"database":"ChEBI","id":"CHEBI:233825"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00095459"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:84464"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00095459"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"(7Z,10Z,13Z)-hexadecatrienoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E,7Z,10Z,13Z)-hexadecatetraenoyl-CoA + reduced [electron-transfer flavoprotein]","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:84599"},{"database":"Rhea","id":"RHEA-COMP:10685"},{"database":"Rhea","id":"RHEA-COMP:10686"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:57692"},{"database":"ChEBI","id":"CHEBI:58307"},{"database":"ChEBI","id":"CHEBI:177091"},{"database":"ChEBI","id":"CHEBI:233792"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00095784"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:84600"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00095784"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"(9E)-octadecenoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E,9E)-octadecadienoyl-CoA + reduced [electron-transfer flavoprotein]","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:48192"},{"database":"Rhea","id":"RHEA-COMP:10685"},{"database":"Rhea","id":"RHEA-COMP:10686"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:57692"},{"database":"ChEBI","id":"CHEBI:58307"},{"database":"ChEBI","id":"CHEBI:77537"},{"database":"ChEBI","id":"CHEBI:77552"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00050339"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:48193"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00050339"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"(9Z)-eicosenoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E,9Z)-eicosadienoyl-CoA + reduced [electron-transfer flavoprotein]","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:83335"},{"database":"Rhea","id":"RHEA-COMP:10685"},{"database":"Rhea","id":"RHEA-COMP:10686"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:57692"},{"database":"ChEBI","id":"CHEBI:58307"},{"database":"ChEBI","id":"CHEBI:232891"},{"database":"ChEBI","id":"CHEBI:232892"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00095725"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:83336"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00095725"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"(9Z)-hexadecenoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E,9Z)-hexadecadienoyl-CoA + reduced [electron-transfer flavoprotein]","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:47304"},{"database":"Rhea","id":"RHEA-COMP:10685"},{"database":"Rhea","id":"RHEA-COMP:10686"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:57692"},{"database":"ChEBI","id":"CHEBI:58307"},{"database":"ChEBI","id":"CHEBI:61540"},{"database":"ChEBI","id":"CHEBI:77549"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00051582"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:47305"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00051582"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"(9Z,12Z)-octadecadienoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E,9Z,12Z)-octadecatrienoyl-CoA + reduced [electron-transfer flavoprotein]","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:48188"},{"database":"Rhea","id":"RHEA-COMP:10685"},{"database":"Rhea","id":"RHEA-COMP:10686"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:57383"},{"database":"ChEBI","id":"CHEBI:57692"},{"database":"ChEBI","id":"CHEBI:58307"},{"database":"ChEBI","id":"CHEBI:77558"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00051128"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:48189"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00051128"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"(9Z,12Z,15Z)-octadecatrienoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E,9Z,12Z,15Z)-octadecatetraenoyl-CoA + reduced [electron-transfer flavoprotein]","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:84595"},{"database":"Rhea","id":"RHEA-COMP:10685"},{"database":"Rhea","id":"RHEA-COMP:10686"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:57692"},{"database":"ChEBI","id":"CHEBI:58307"},{"database":"ChEBI","id":"CHEBI:74034"},{"database":"ChEBI","id":"CHEBI:233840"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00095716"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:84596"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00095716"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"a long-chain 2,3-saturated fatty acyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = a long-chain (2E)-enoyl-CoA + reduced [electron-transfer flavoprotein]","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:17721"},{"database":"Rhea","id":"RHEA-COMP:10685"},{"database":"Rhea","id":"RHEA-COMP:10686"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:57692"},{"database":"ChEBI","id":"CHEBI:58307"},{"database":"ChEBI","id":"CHEBI:83721"},{"database":"ChEBI","id":"CHEBI:83727"}],"ecNumber":"1.3.8.8","evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00047434"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:17722"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00047434"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"a medium-chain 2,3-saturated fatty acyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = a medium-chain (2E)-enoyl-CoA + reduced [electron-transfer flavoprotein]","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:14477"},{"database":"Rhea","id":"RHEA-COMP:10685"},{"database":"Rhea","id":"RHEA-COMP:10686"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:57692"},{"database":"ChEBI","id":"CHEBI:58307"},{"database":"ChEBI","id":"CHEBI:83723"},{"database":"ChEBI","id":"CHEBI:83726"}],"ecNumber":"1.3.8.7","evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00048063"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:14478"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00048063"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"decanoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E)-decenoyl-CoA + reduced [electron-transfer flavoprotein]","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:48176"},{"database":"Rhea","id":"RHEA-COMP:10685"},{"database":"Rhea","id":"RHEA-COMP:10686"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:57692"},{"database":"ChEBI","id":"CHEBI:58307"},{"database":"ChEBI","id":"CHEBI:61406"},{"database":"ChEBI","id":"CHEBI:61430"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00047546"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:48177"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00047546"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"dodecanoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E)-dodecenoyl-CoA + reduced [electron-transfer flavoprotein]","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:47296"},{"database":"Rhea","id":"RHEA-COMP:10685"},{"database":"Rhea","id":"RHEA-COMP:10686"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:57330"},{"database":"ChEBI","id":"CHEBI:57375"},{"database":"ChEBI","id":"CHEBI:57692"},{"database":"ChEBI","id":"CHEBI:58307"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00047893"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:47297"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00047893"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"eicosanoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E)-eicosenoyl-CoA + reduced [electron-transfer flavoprotein]","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:47236"},{"database":"Rhea","id":"RHEA-COMP:10685"},{"database":"Rhea","id":"RHEA-COMP:10686"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:57380"},{"database":"ChEBI","id":"CHEBI:57692"},{"database":"ChEBI","id":"CHEBI:58307"},{"database":"ChEBI","id":"CHEBI:74691"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00049140"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:47237"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00049140"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"heptadecanoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = trans-2-heptadecenoyl-CoA + reduced [electron-transfer flavoprotein]","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:48196"},{"database":"Rhea","id":"RHEA-COMP:10685"},{"database":"Rhea","id":"RHEA-COMP:10686"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:57692"},{"database":"ChEBI","id":"CHEBI:58307"},{"database":"ChEBI","id":"CHEBI:74307"},{"database":"ChEBI","id":"CHEBI:77551"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00052354"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:48197"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00052354"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"nonanoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E)-nonenoyl-CoA + reduced [electron-transfer flavoprotein]","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:48208"},{"database":"Rhea","id":"RHEA-COMP:10685"},{"database":"Rhea","id":"RHEA-COMP:10686"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:57692"},{"database":"ChEBI","id":"CHEBI:58307"},{"database":"ChEBI","id":"CHEBI:76291"},{"database":"ChEBI","id":"CHEBI:76292"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00052466"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:48209"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00052466"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"octadecanoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E)-octadecenoyl-CoA + reduced [electron-transfer flavoprotein]","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:47240"},{"database":"Rhea","id":"RHEA-COMP:10685"},{"database":"Rhea","id":"RHEA-COMP:10686"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:57394"},{"database":"ChEBI","id":"CHEBI:57692"},{"database":"ChEBI","id":"CHEBI:58307"},{"database":"ChEBI","id":"CHEBI:71412"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00049224"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:47241"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00049224"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"oxidized [electron-transfer flavoprotein] + (9Z)-octadecenoyl-CoA + H(+) = (2E,9Z)-octadecadienoyl-CoA + reduced [electron-transfer flavoprotein]","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:47300"},{"database":"Rhea","id":"RHEA-COMP:10685"},{"database":"Rhea","id":"RHEA-COMP:10686"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:57387"},{"database":"ChEBI","id":"CHEBI:57692"},{"database":"ChEBI","id":"CHEBI:58307"},{"database":"ChEBI","id":"CHEBI:77553"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00048725"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:47301"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00048725"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"oxidized [electron-transfer flavoprotein] + hexadecanoyl-CoA + H(+) = (2E)-hexadecenoyl-CoA + reduced [electron-transfer flavoprotein]","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:43448"},{"database":"Rhea","id":"RHEA-COMP:10685"},{"database":"Rhea","id":"RHEA-COMP:10686"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:57379"},{"database":"ChEBI","id":"CHEBI:57692"},{"database":"ChEBI","id":"CHEBI:58307"},{"database":"ChEBI","id":"CHEBI:61526"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00047916"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:43449"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00047916"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"pentadecanoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E)-pentadecenoyl-CoA + reduced [electron-transfer flavoprotein]","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:48204"},{"database":"Rhea","id":"RHEA-COMP:10685"},{"database":"Rhea","id":"RHEA-COMP:10686"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:57692"},{"database":"ChEBI","id":"CHEBI:58307"},{"database":"ChEBI","id":"CHEBI:74309"},{"database":"ChEBI","id":"CHEBI:77545"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00050383"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:48205"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00050383"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"tetradecanoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E)-tetradecenoyl-CoA + reduced [electron-transfer flavoprotein]","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:47316"},{"database":"Rhea","id":"RHEA-COMP:10685"},{"database":"Rhea","id":"RHEA-COMP:10686"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:57385"},{"database":"ChEBI","id":"CHEBI:57692"},{"database":"ChEBI","id":"CHEBI:58307"},{"database":"ChEBI","id":"CHEBI:61405"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00049038"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:47317"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00049038"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"undecanoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = trans-2-undecenoyl-CoA + reduced [electron-transfer flavoprotein]","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:48200"},{"database":"Rhea","id":"RHEA-COMP:10685"},{"database":"Rhea","id":"RHEA-COMP:10686"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:57692"},{"database":"ChEBI","id":"CHEBI:58307"},{"database":"ChEBI","id":"CHEBI:77547"},{"database":"ChEBI","id":"CHEBI:77548"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00052438"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:48201"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00052438"}]}]},{"commentType":"COFACTOR","cofactors":[{"name":"FAD","evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00001974"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU362125"}],"cofactorCrossReference":{"database":"ChEBI","id":"CHEBI:57692"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00064101"}],"value":"Homodimer. Interacts with NDUFAF1 and ECSIT. Part of the mitochondrial complex I assembly/MCIA complex that comprises at least the core subunits TMEM126B, NDUFAF1, ECSIT and ACAD9 and complement subunits such as COA1 and TMEM186. Interacts with TMEM70 and TMEM242"}],"commentType":"SUBUNIT"},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004443"}],"value":"Mitochondrion inner membrane","id":"SL-0168"},"topology":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004443"}],"value":"Peripheral membrane protein","id":"SL-9903"},"orientation":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004443"}],"value":"Matrix side","id":"SL-9913"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00009347"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU362125"}],"value":"Belongs to the acyl-CoA dehydrogenase family"}],"commentType":"SIMILARITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"NXE19737.1"}],"value":"The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data"}],"commentType":"CAUTION"}],"features":[{"type":"Domain","location":{"start":{"value":15,"modifier":"EXACT"},"end":{"value":123,"modifier":"EXACT"}},"description":"Acyl-CoA dehydrogenase/oxidase N-terminal","evidences":[{"evidenceCode":"ECO:0000259","source":"Pfam","id":"PF02771"}]},{"type":"Domain","location":{"start":{"value":127,"modifier":"EXACT"},"end":{"value":227,"modifier":"EXACT"}},"description":"Acyl-CoA dehydrogenase/oxidase middle","evidences":[{"evidenceCode":"ECO:0000259","source":"Pfam","id":"PF02770"}]},{"type":"Domain","location":{"start":{"value":240,"modifier":"EXACT"},"end":{"value":393,"modifier":"EXACT"}},"description":"Acyl-CoA dehydrogenase/oxidase C-terminal","evidences":[{"evidenceCode":"ECO:0000259","source":"Pfam","id":"PF00441"}]},{"type":"Domain","location":{"start":{"value":448,"modifier":"EXACT"},"end":{"value":566,"modifier":"EXACT"}},"description":"ACAD9/ACADV-like C-terminal","evidences":[{"evidenceCode":"ECO:0000259","source":"Pfam","id":"PF21343"}]},{"type":"Non-terminal residue","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":1,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"NXE19737.1"}]},{"type":"Non-terminal residue","location":{"start":{"value":577,"modifier":"EXACT"},"end":{"value":577,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"NXE19737.1"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022990"}],"id":"KW-0007","category":"PTM","name":"Acetylation"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022827"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU362125"}],"id":"KW-0274","category":"Ligand","name":"FAD"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022630"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU362125"}],"id":"KW-0285","category":"Ligand","name":"Flavoprotein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023136"}],"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023128"}],"id":"KW-0496","category":"Cellular component","name":"Mitochondrion"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022792"}],"id":"KW-0999","category":"Cellular component","name":"Mitochondrion inner membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023002"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU362125"}],"id":"KW-0560","category":"Molecular function","name":"Oxidoreductase"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022553"}],"id":"KW-0597","category":"PTM","name":"Phosphoprotein"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000560386"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022946"}],"id":"KW-0809","category":"Domain","name":"Transit peptide"}],"references":[{"referenceNumber":1,"citation":{"id":"CI-90S2KOISV381S","citationType":"submission","authors":["Zhang G."],"title":"Bird 10,000 Genomes (B10K) Project - Family phase.","publicationDate":"SEP-2019","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"NXE19737.1"}],"value":"B10K-CU-031-01","type":"STRAIN"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"NXE19737.1"}],"value":"Muscle","type":"TISSUE"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"NXE19737.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000560386"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"VWPR01000096","properties":[{"key":"ProteinId","value":"NXE19737.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"AlphaFoldDB","id":"A0A7K8KRL6","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000560386","properties":[{"key":"Component","value":"Unassembled WGS sequence"}]},{"database":"GO","id":"GO:0005743","properties":[{"key":"GoTerm","value":"C:mitochondrial inner membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0050660","properties":[{"key":"GoTerm","value":"F:flavin adenine dinucleotide binding"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0004466","properties":[{"key":"GoTerm","value":"F:long-chain fatty acyl-CoA dehydrogenase activity"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-EC"}]},{"database":"GO","id":"GO:0070991","properties":[{"key":"GoTerm","value":"F:medium-chain fatty acyl-CoA dehydrogenase activity"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-EC"}]},{"database":"GO","id":"GO:0006631","properties":[{"key":"GoTerm","value":"P:fatty acid metabolic process"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"CDD","id":"cd01161","properties":[{"key":"EntryName","value":"VLCAD"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.140.10:FF:000023","properties":[{"key":"EntryName","value":"Acyl-CoA dehydrogenase family member 9"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.140.10:FF:000008","properties":[{"key":"EntryName","value":"acyl-CoA dehydrogenase family member 9, mitochondrial"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.40.110.10:FF:000006","properties":[{"key":"EntryName","value":"very long-chain specific acyl-CoA dehydrogenase, mitochondrial"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.10.540.10:FF:000001","properties":[{"key":"EntryName","value":"Very long-chain-specific acyl-CoA dehydrogenase, mitochondrial"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.10.540.10","properties":[{"key":"EntryName","value":"Acyl-CoA dehydrogenase/oxidase, N-terminal domain"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.40.110.10","properties":[{"key":"EntryName","value":"Butyryl-CoA Dehydrogenase, subunit A, domain 2"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.20.140.10","properties":[{"key":"EntryName","value":"Butyryl-CoA Dehydrogenase, subunit A, domain 3"},{"key":"MatchStatus","value":"2"}]},{"database":"InterPro","id":"IPR049448","properties":[{"key":"EntryName","value":"ACAD9/ACADV-like_C"}]},{"database":"InterPro","id":"IPR006089","properties":[{"key":"EntryName","value":"Acyl-CoA_DH_CS"}]},{"database":"InterPro","id":"IPR046373","properties":[{"key":"EntryName","value":"Acyl-CoA_Oxase/DH_mid-dom_sf"}]},{"database":"InterPro","id":"IPR036250","properties":[{"key":"EntryName","value":"AcylCo_DH-like_C"}]},{"database":"InterPro","id":"IPR009075","properties":[{"key":"EntryName","value":"AcylCo_DH/oxidase_C"}]},{"database":"InterPro","id":"IPR006091","properties":[{"key":"EntryName","value":"AcylCoA_DH/ox_M"}]},{"database":"InterPro","id":"IPR013786","properties":[{"key":"EntryName","value":"AcylCoA_DH/ox_N"}]},{"database":"InterPro","id":"IPR037069","properties":[{"key":"EntryName","value":"AcylCoA_DH/ox_N_sf"}]},{"database":"InterPro","id":"IPR009100","properties":[{"key":"EntryName","value":"AcylCoA_DH/oxidase_NM_dom_sf"}]},{"database":"PANTHER","id":"PTHR43884","properties":[{"key":"EntryName","value":"ACYL-COA DEHYDROGENASE"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR43884:SF9","properties":[{"key":"EntryName","value":"COMPLEX I ASSEMBLY FACTOR ACAD9, MITOCHONDRIAL"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF21343","properties":[{"key":"EntryName","value":"ACAD9-ACADV_C"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00441","properties":[{"key":"EntryName","value":"Acyl-CoA_dh_1"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF02770","properties":[{"key":"EntryName","value":"Acyl-CoA_dh_M"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF02771","properties":[{"key":"EntryName","value":"Acyl-CoA_dh_N"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF47203","properties":[{"key":"EntryName","value":"Acyl-CoA dehydrogenase C-terminal domain-like"},{"key":"MatchStatus","value":"2"}]},{"database":"SUPFAM","id":"SSF56645","properties":[{"key":"EntryName","value":"Acyl-CoA dehydrogenase NM domain-like"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00072","properties":[{"key":"EntryName","value":"ACYL_COA_DH_1"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00073","properties":[{"key":"EntryName","value":"ACYL_COA_DH_2"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"EEVFPYPEISNEELEEINQFVGPVEKFFNEEVDSKRIDRDAKIPLETLKGLKDLGLFGMQIPEEYGGLGLSNTMYARLGEITALDGSIAVTLAAHQAIGLKGILIAGTDEQKAKYLPRLASGEHIAAFCLTEPGSGSDAASIQTRATLSEDGKYFLLNGSKVWISNGGLASIFTVFARTEVVDKDGQVKDKITAFIVERDFGGVTHGKPEDKLGIRGSNTCEVHFENTKVPIENVIGEVGGGFKVAMNILNSGRFSMGSASAGMIKKLIEMTAEFACTRKQFNKRLSEFGLIQEKFCFMAVKAYVMESMAYLTAGMMDRPGFPDCSVEAAMVKVFSSEGAWACVSEALQILGGLGYMKDYPYERYLRDTRILLIFEASTNRLGTNEILRMYIALTGMQYAGKILTDKIKEIKKGNVGVALGELLNKLRDSMGRKVDYGLVGDRGVVHPSLQESGKKLEENIYYFGTTVRGLLTRFGKTIVDEQLVLKRVADIIINLYAMTATISRASRSISIGLRNHDHEVLLTNIFCTEAYFKNNYAMAQLQKYADENLDDHIKKAAKQVLEKRAYICSHPLDRTF","length":577,"molWeight":63824,"crc64":"6D0B84F7E5E38F50","md5":"9F98AD1C95F9F9103BD4A88B71CFE89E"},"extraAttributes":{"countByCommentType":{"CATALYTIC ACTIVITY":42,"COFACTOR":1,"SUBUNIT":1,"SUBCELLULAR LOCATION":1,"SIMILARITY":1,"CAUTION":1},"countByFeatureType":{"Domain":4,"Non-terminal residue":2},"uniParcId":"UPI0017DE5039"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0A7K8KRN4","uniProtkbId":"A0A7K8KRN4_9AVES","entryAudit":{"firstPublicDate":"2021-04-07","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2021-04-07","entryVersion":19,"sequenceVersion":1},"annotationScore":5.0,"organism":{"scientificName":"Ardeotis kori","taxonId":89386,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"NXE19758.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000560386"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Archelosauria","Archosauria","Dinosauria","Saurischia","Theropoda","Coelurosauria","Aves","Neognathae","Neoaves","Otidimorphae","Otidiformes","Otididae","Ardeotis"]},"proteinExistence":"3: Inferred from homology","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00014123"}],"value":"Long-chain specific acyl-CoA dehydrogenase, mitochondrial"},"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00012033"}],"value":"1.3.8.7"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00012040"}],"value":"1.3.8.8"}]},"alternativeNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00095042"}],"value":"Medium-chain acyl-CoA dehydrogenase, mitochondrial"}}],"flag":"Fragment"},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"NXE19758.1"}],"value":"Acadl"},"orfNames":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"NXE19758.1"}],"value":"ARDKOR_R11882"}]}],"comments":[{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"(11Z)-docosenoyl-CoA(4-) + oxidized [electron-transfer flavoprotein] + H(+) = (2E,11Z)-docosadienoyl-CoA + reduced [electron-transfer flavoprotein]","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:83291"},{"database":"Rhea","id":"RHEA-COMP:10685"},{"database":"Rhea","id":"RHEA-COMP:10686"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:57692"},{"database":"ChEBI","id":"CHEBI:58307"},{"database":"ChEBI","id":"CHEBI:232625"},{"database":"ChEBI","id":"CHEBI:232888"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00095757"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:83292"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00095757"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"(11Z)-eicosenoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E,11Z)-eicosadienoyl-CoA + reduced [electron-transfer flavoprotein]","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:83055"},{"database":"Rhea","id":"RHEA-COMP:10685"},{"database":"Rhea","id":"RHEA-COMP:10686"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:57692"},{"database":"ChEBI","id":"CHEBI:58307"},{"database":"ChEBI","id":"CHEBI:74069"},{"database":"ChEBI","id":"CHEBI:76388"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00095658"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:83056"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00095658"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"(11Z)-octadecenoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E,11Z)-octadecadienoyl-CoA + reduced [electron-transfer flavoprotein]","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:83023"},{"database":"Rhea","id":"RHEA-COMP:10685"},{"database":"Rhea","id":"RHEA-COMP:10686"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:57692"},{"database":"ChEBI","id":"CHEBI:58307"},{"database":"ChEBI","id":"CHEBI:75121"},{"database":"ChEBI","id":"CHEBI:76558"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00095584"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:83024"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00095584"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"(13Z)-docosenoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E,13Z)-docosadienoyl-CoA + reduced [electron-transfer flavoprotein]","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:83051"},{"database":"Rhea","id":"RHEA-COMP:10685"},{"database":"Rhea","id":"RHEA-COMP:10686"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:57692"},{"database":"ChEBI","id":"CHEBI:58307"},{"database":"ChEBI","id":"CHEBI:74068"},{"database":"ChEBI","id":"CHEBI:76391"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00095463"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:83052"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00095463"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"(4Z)-decenoyl-CoA(4-) + oxidized [electron-transfer flavoprotein] + H(+) = (2E,4Z)-decadienoyl-CoA + reduced [electron-transfer flavoprotein]","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:84475"},{"database":"Rhea","id":"RHEA-COMP:10685"},{"database":"Rhea","id":"RHEA-COMP:10686"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:57692"},{"database":"ChEBI","id":"CHEBI:58307"},{"database":"ChEBI","id":"CHEBI:137593"},{"database":"ChEBI","id":"CHEBI:233838"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00095446"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:84476"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00095446"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"(4Z)-hexadecenoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E,4Z)-hexadecadienoyl-CoA + reduced [electron-transfer flavoprotein]","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:83223"},{"database":"Rhea","id":"RHEA-COMP:10685"},{"database":"Rhea","id":"RHEA-COMP:10686"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:57692"},{"database":"ChEBI","id":"CHEBI:58307"},{"database":"ChEBI","id":"CHEBI:232775"},{"database":"ChEBI","id":"CHEBI:232776"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00095427"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:83224"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00095427"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"(4Z)-tetradecenoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E,4Z)-tetradecadienoyl-CoA + reduced [electron-transfer flavoprotein]","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:83159"},{"database":"Rhea","id":"RHEA-COMP:10685"},{"database":"Rhea","id":"RHEA-COMP:10686"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:57692"},{"database":"ChEBI","id":"CHEBI:58307"},{"database":"ChEBI","id":"CHEBI:232764"},{"database":"ChEBI","id":"CHEBI:232765"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00095510"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:83160"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00095510"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"(4Z,7Z)-decadienoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E,4Z,7Z)-decatrienoyl-CoA + reduced [electron-transfer flavoprotein]","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:84611"},{"database":"Rhea","id":"RHEA-COMP:10685"},{"database":"Rhea","id":"RHEA-COMP:10686"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:57692"},{"database":"ChEBI","id":"CHEBI:58307"},{"database":"ChEBI","id":"CHEBI:233850"},{"database":"ChEBI","id":"CHEBI:233851"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00095565"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:84612"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00095565"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"(4Z,7Z,10Z)-hexadecatrienoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E,4Z,7Z,10Z)-hexadecatetraenoyl-CoA + reduced [electron-transfer flavoprotein]","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:84623"},{"database":"Rhea","id":"RHEA-COMP:10685"},{"database":"Rhea","id":"RHEA-COMP:10686"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:57692"},{"database":"ChEBI","id":"CHEBI:58307"},{"database":"ChEBI","id":"CHEBI:233781"},{"database":"ChEBI","id":"CHEBI:233783"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00095501"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:84624"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00095501"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"(4Z,7Z,10Z,13Z)-hexadecatetraenoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E,4Z,7Z,10Z,13Z)-hexadecapentaenoyl-CoA + reduced [electron-transfer flavoprotein]","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:85123"},{"database":"Rhea","id":"RHEA-COMP:10685"},{"database":"Rhea","id":"RHEA-COMP:10686"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:57692"},{"database":"ChEBI","id":"CHEBI:58307"},{"database":"ChEBI","id":"CHEBI:233765"},{"database":"ChEBI","id":"CHEBI:233790"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00095626"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:85124"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00095626"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"(5E)-tetradecenoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E,5E)-tetradecadienoyl-CoA + reduced [electron-transfer flavoprotein]","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:49828"},{"database":"Rhea","id":"RHEA-COMP:10685"},{"database":"Rhea","id":"RHEA-COMP:10686"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:57692"},{"database":"ChEBI","id":"CHEBI:58307"},{"database":"ChEBI","id":"CHEBI:131943"},{"database":"ChEBI","id":"CHEBI:131944"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00051766"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:49829"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00051766"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"(5Z)-dodecenoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E,5Z)-dodecadienoyl-CoA + reduced [electron-transfer flavoprotein]","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:82951"},{"database":"Rhea","id":"RHEA-COMP:10685"},{"database":"Rhea","id":"RHEA-COMP:10686"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:57692"},{"database":"ChEBI","id":"CHEBI:58307"},{"database":"ChEBI","id":"CHEBI:230464"},{"database":"ChEBI","id":"CHEBI:232684"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00095627"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:82952"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00095627"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"(5Z)-hexadecenoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E,5Z)-hexadecadienoyl-CoA + reduced [electron-transfer flavoprotein]","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:83387"},{"database":"Rhea","id":"RHEA-COMP:10685"},{"database":"Rhea","id":"RHEA-COMP:10686"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:57692"},{"database":"ChEBI","id":"CHEBI:58307"},{"database":"ChEBI","id":"CHEBI:232908"},{"database":"ChEBI","id":"CHEBI:232910"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00095447"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:83388"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00095447"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"(5Z)-tetradecenoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E,5Z)-tetradecadienoyl-CoA + reduced [electron-transfer flavoprotein]","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:47448"},{"database":"Rhea","id":"RHEA-COMP:10685"},{"database":"Rhea","id":"RHEA-COMP:10686"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:57692"},{"database":"ChEBI","id":"CHEBI:58307"},{"database":"ChEBI","id":"CHEBI:84650"},{"database":"ChEBI","id":"CHEBI:87701"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00048187"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:47449"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00048187"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"(5Z,8Z)-tetradecadienoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E,5Z,8Z)-tetradecatrienoyl-CoA + reduced [electron-transfer flavoprotein]","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:84467"},{"database":"Rhea","id":"RHEA-COMP:10685"},{"database":"Rhea","id":"RHEA-COMP:10686"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:57692"},{"database":"ChEBI","id":"CHEBI:58307"},{"database":"ChEBI","id":"CHEBI:233789"},{"database":"ChEBI","id":"CHEBI:233827"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00095729"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:84468"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00095729"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"(5Z,8Z,11Z)-tetradecatrienoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E,5Z,8Z,11Z)-tetradecatetraenoyl-CoA + reduced [electron-transfer flavoprotein]","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:84603"},{"database":"Rhea","id":"RHEA-COMP:10685"},{"database":"Rhea","id":"RHEA-COMP:10686"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:57692"},{"database":"ChEBI","id":"CHEBI:58307"},{"database":"ChEBI","id":"CHEBI:233795"},{"database":"ChEBI","id":"CHEBI:233796"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00095764"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:84604"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00095764"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"(6Z)-dodecenoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E,6Z)-dodecadienoyl-CoA + reduced [electron-transfer flavoprotein]","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:84471"},{"database":"Rhea","id":"RHEA-COMP:10685"},{"database":"Rhea","id":"RHEA-COMP:10686"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:57692"},{"database":"ChEBI","id":"CHEBI:58307"},{"database":"ChEBI","id":"CHEBI:233834"},{"database":"ChEBI","id":"CHEBI:233835"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00095438"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:84472"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00095438"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"(6Z)-hexadecenoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E,6Z)-hexadecadienoyl-CoA + reduced [electron-transfer flavoprotein]","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:83155"},{"database":"Rhea","id":"RHEA-COMP:10685"},{"database":"Rhea","id":"RHEA-COMP:10686"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:57692"},{"database":"ChEBI","id":"CHEBI:58307"},{"database":"ChEBI","id":"CHEBI:74339"},{"database":"ChEBI","id":"CHEBI:232761"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00095629"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:83156"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00095629"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"(6Z)-octadecenoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E,6Z)-octadecadienoyl-CoA + reduced [electron-transfer flavoprotein]","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:83207"},{"database":"Rhea","id":"RHEA-COMP:10685"},{"database":"Rhea","id":"RHEA-COMP:10686"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:57692"},{"database":"ChEBI","id":"CHEBI:58307"},{"database":"ChEBI","id":"CHEBI:75123"},{"database":"ChEBI","id":"CHEBI:232772"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00095603"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:83208"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00095603"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"(6Z,9Z)-dodecadienoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E,6Z,9Z)-dodecatrienoyl-CoA + reduced [electron-transfer flavoprotein]","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:84607"},{"database":"Rhea","id":"RHEA-COMP:10685"},{"database":"Rhea","id":"RHEA-COMP:10686"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:57692"},{"database":"ChEBI","id":"CHEBI:58307"},{"database":"ChEBI","id":"CHEBI:233810"},{"database":"ChEBI","id":"CHEBI:233847"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00095680"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:84608"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00095680"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"(6Z,9Z,12Z)-octadecatrienoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E,6Z,9Z,12Z)-octadecatetraenoyl-CoA + reduced [electron-transfer flavoprotein]","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:84619"},{"database":"Rhea","id":"RHEA-COMP:10685"},{"database":"Rhea","id":"RHEA-COMP:10686"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:57363"},{"database":"ChEBI","id":"CHEBI:57692"},{"database":"ChEBI","id":"CHEBI:58307"},{"database":"ChEBI","id":"CHEBI:233778"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00095487"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:84620"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00095487"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"(6Z,9Z,12Z,15Z)-octadecatetraenoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E,6Z,9Z,12Z,15Z)-octadecapentaenoyl-CoA + reduced [electron-transfer flavoprotein]","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:85107"},{"database":"Rhea","id":"RHEA-COMP:10685"},{"database":"Rhea","id":"RHEA-COMP:10686"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:57692"},{"database":"ChEBI","id":"CHEBI:58307"},{"database":"ChEBI","id":"CHEBI:71489"},{"database":"ChEBI","id":"CHEBI:233740"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00095474"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:85108"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00095474"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"(7Z)-hexadecenoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E,7Z)-hexadecadienoyl-CoA + reduced [electron-transfer flavoprotein]","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:47432"},{"database":"Rhea","id":"RHEA-COMP:10685"},{"database":"Rhea","id":"RHEA-COMP:10686"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:57692"},{"database":"ChEBI","id":"CHEBI:58307"},{"database":"ChEBI","id":"CHEBI:87698"},{"database":"ChEBI","id":"CHEBI:87717"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00095469"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:47433"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00095469"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"(7Z)-octadecenoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E,7Z)-octadecadienoyl-CoA + reduced [electron-transfer flavoprotein]","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:83371"},{"database":"Rhea","id":"RHEA-COMP:10685"},{"database":"Rhea","id":"RHEA-COMP:10686"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:57692"},{"database":"ChEBI","id":"CHEBI:58307"},{"database":"ChEBI","id":"CHEBI:152050"},{"database":"ChEBI","id":"CHEBI:232899"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00095536"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:83372"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00095536"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"(7Z)-tetradecenoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E,7Z)-tetradecadienoyl-CoA + reduced [electron-transfer flavoprotein]","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:82939"},{"database":"Rhea","id":"RHEA-COMP:10685"},{"database":"Rhea","id":"RHEA-COMP:10686"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:57692"},{"database":"ChEBI","id":"CHEBI:58307"},{"database":"ChEBI","id":"CHEBI:232643"},{"database":"ChEBI","id":"CHEBI:232680"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00095631"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:82940"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00095631"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"(7Z,10Z)-hexadecadienoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E,7Z,10Z)-hexadecatrienoyl-CoA + reduced [electron-transfer flavoprotein]","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:84463"},{"database":"Rhea","id":"RHEA-COMP:10685"},{"database":"Rhea","id":"RHEA-COMP:10686"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:57692"},{"database":"ChEBI","id":"CHEBI:58307"},{"database":"ChEBI","id":"CHEBI:233785"},{"database":"ChEBI","id":"CHEBI:233825"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00095459"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:84464"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00095459"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"(7Z,10Z,13Z)-hexadecatrienoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E,7Z,10Z,13Z)-hexadecatetraenoyl-CoA + reduced [electron-transfer flavoprotein]","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:84599"},{"database":"Rhea","id":"RHEA-COMP:10685"},{"database":"Rhea","id":"RHEA-COMP:10686"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:57692"},{"database":"ChEBI","id":"CHEBI:58307"},{"database":"ChEBI","id":"CHEBI:177091"},{"database":"ChEBI","id":"CHEBI:233792"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00095784"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:84600"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00095784"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"(9Z)-eicosenoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E,9Z)-eicosadienoyl-CoA + reduced [electron-transfer flavoprotein]","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:83335"},{"database":"Rhea","id":"RHEA-COMP:10685"},{"database":"Rhea","id":"RHEA-COMP:10686"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:57692"},{"database":"ChEBI","id":"CHEBI:58307"},{"database":"ChEBI","id":"CHEBI:232891"},{"database":"ChEBI","id":"CHEBI:232892"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00095725"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:83336"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00095725"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"(9Z)-hexadecenoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E,9Z)-hexadecadienoyl-CoA + reduced [electron-transfer flavoprotein]","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:47304"},{"database":"Rhea","id":"RHEA-COMP:10685"},{"database":"Rhea","id":"RHEA-COMP:10686"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:57692"},{"database":"ChEBI","id":"CHEBI:58307"},{"database":"ChEBI","id":"CHEBI:61540"},{"database":"ChEBI","id":"CHEBI:77549"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00051582"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:47305"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00051582"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"(9Z,12Z)-octadecadienoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E,9Z,12Z)-octadecatrienoyl-CoA + reduced [electron-transfer flavoprotein]","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:48188"},{"database":"Rhea","id":"RHEA-COMP:10685"},{"database":"Rhea","id":"RHEA-COMP:10686"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:57383"},{"database":"ChEBI","id":"CHEBI:57692"},{"database":"ChEBI","id":"CHEBI:58307"},{"database":"ChEBI","id":"CHEBI:77558"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00051128"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:48189"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00051128"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"(9Z,12Z,15Z)-octadecatrienoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E,9Z,12Z,15Z)-octadecatetraenoyl-CoA + reduced [electron-transfer flavoprotein]","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:84595"},{"database":"Rhea","id":"RHEA-COMP:10685"},{"database":"Rhea","id":"RHEA-COMP:10686"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:57692"},{"database":"ChEBI","id":"CHEBI:58307"},{"database":"ChEBI","id":"CHEBI:74034"},{"database":"ChEBI","id":"CHEBI:233840"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00095716"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:84596"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00095716"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"a long-chain 2,3-saturated fatty acyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = a long-chain (2E)-enoyl-CoA + reduced [electron-transfer flavoprotein]","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:17721"},{"database":"Rhea","id":"RHEA-COMP:10685"},{"database":"Rhea","id":"RHEA-COMP:10686"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:57692"},{"database":"ChEBI","id":"CHEBI:58307"},{"database":"ChEBI","id":"CHEBI:83721"},{"database":"ChEBI","id":"CHEBI:83727"}],"ecNumber":"1.3.8.8","evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00047434"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:17722"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00047434"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"a medium-chain 2,3-saturated fatty acyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = a medium-chain (2E)-enoyl-CoA + reduced [electron-transfer flavoprotein]","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:14477"},{"database":"Rhea","id":"RHEA-COMP:10685"},{"database":"Rhea","id":"RHEA-COMP:10686"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:57692"},{"database":"ChEBI","id":"CHEBI:58307"},{"database":"ChEBI","id":"CHEBI:83723"},{"database":"ChEBI","id":"CHEBI:83726"}],"ecNumber":"1.3.8.7","evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00048063"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:14478"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00048063"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"decanoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E)-decenoyl-CoA + reduced [electron-transfer flavoprotein]","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:48176"},{"database":"Rhea","id":"RHEA-COMP:10685"},{"database":"Rhea","id":"RHEA-COMP:10686"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:57692"},{"database":"ChEBI","id":"CHEBI:58307"},{"database":"ChEBI","id":"CHEBI:61406"},{"database":"ChEBI","id":"CHEBI:61430"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00047546"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:48177"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00047546"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"docosanoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E)-docosenoyl-CoA + reduced [electron-transfer flavoprotein]","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:47228"},{"database":"Rhea","id":"RHEA-COMP:10685"},{"database":"Rhea","id":"RHEA-COMP:10686"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:57692"},{"database":"ChEBI","id":"CHEBI:58307"},{"database":"ChEBI","id":"CHEBI:65059"},{"database":"ChEBI","id":"CHEBI:74692"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00048020"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:47229"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00048020"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"dodecanoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E)-dodecenoyl-CoA + reduced [electron-transfer flavoprotein]","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:47296"},{"database":"Rhea","id":"RHEA-COMP:10685"},{"database":"Rhea","id":"RHEA-COMP:10686"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:57330"},{"database":"ChEBI","id":"CHEBI:57375"},{"database":"ChEBI","id":"CHEBI:57692"},{"database":"ChEBI","id":"CHEBI:58307"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00047893"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:47297"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00047893"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"eicosanoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E)-eicosenoyl-CoA + reduced [electron-transfer flavoprotein]","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:47236"},{"database":"Rhea","id":"RHEA-COMP:10685"},{"database":"Rhea","id":"RHEA-COMP:10686"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:57380"},{"database":"ChEBI","id":"CHEBI:57692"},{"database":"ChEBI","id":"CHEBI:58307"},{"database":"ChEBI","id":"CHEBI:74691"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00049140"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:47237"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00049140"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"hexanoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E)-hexenoyl-CoA + reduced [electron-transfer flavoprotein]","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:43464"},{"database":"Rhea","id":"RHEA-COMP:10685"},{"database":"Rhea","id":"RHEA-COMP:10686"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:57692"},{"database":"ChEBI","id":"CHEBI:58307"},{"database":"ChEBI","id":"CHEBI:62077"},{"database":"ChEBI","id":"CHEBI:62620"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00049192"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:43465"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00049192"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"octadecanoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E)-octadecenoyl-CoA + reduced [electron-transfer flavoprotein]","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:47240"},{"database":"Rhea","id":"RHEA-COMP:10685"},{"database":"Rhea","id":"RHEA-COMP:10686"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:57394"},{"database":"ChEBI","id":"CHEBI:57692"},{"database":"ChEBI","id":"CHEBI:58307"},{"database":"ChEBI","id":"CHEBI:71412"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00049224"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:47241"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00049224"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"octanoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E)-octenoyl-CoA + reduced [electron-transfer flavoprotein]","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:48180"},{"database":"Rhea","id":"RHEA-COMP:10685"},{"database":"Rhea","id":"RHEA-COMP:10686"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:57386"},{"database":"ChEBI","id":"CHEBI:57692"},{"database":"ChEBI","id":"CHEBI:58307"},{"database":"ChEBI","id":"CHEBI:62242"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00048877"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:48181"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00048877"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"oxidized [electron-transfer flavoprotein] + (9Z)-octadecenoyl-CoA + H(+) = (2E,9Z)-octadecadienoyl-CoA + reduced [electron-transfer flavoprotein]","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:47300"},{"database":"Rhea","id":"RHEA-COMP:10685"},{"database":"Rhea","id":"RHEA-COMP:10686"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:57387"},{"database":"ChEBI","id":"CHEBI:57692"},{"database":"ChEBI","id":"CHEBI:58307"},{"database":"ChEBI","id":"CHEBI:77553"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00048725"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:47301"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00048725"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"oxidized [electron-transfer flavoprotein] + hexadecanoyl-CoA + H(+) = (2E)-hexadecenoyl-CoA + reduced [electron-transfer flavoprotein]","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:43448"},{"database":"Rhea","id":"RHEA-COMP:10685"},{"database":"Rhea","id":"RHEA-COMP:10686"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:57379"},{"database":"ChEBI","id":"CHEBI:57692"},{"database":"ChEBI","id":"CHEBI:58307"},{"database":"ChEBI","id":"CHEBI:61526"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00047916"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:43449"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00047916"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"tetradecanoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E)-tetradecenoyl-CoA + reduced [electron-transfer flavoprotein]","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:47316"},{"database":"Rhea","id":"RHEA-COMP:10685"},{"database":"Rhea","id":"RHEA-COMP:10686"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:57385"},{"database":"ChEBI","id":"CHEBI:57692"},{"database":"ChEBI","id":"CHEBI:58307"},{"database":"ChEBI","id":"CHEBI:61405"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00049038"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:47317"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00049038"}]}]},{"commentType":"COFACTOR","cofactors":[{"name":"FAD","evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00001974"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU362125"}],"cofactorCrossReference":{"database":"ChEBI","id":"CHEBI:57692"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00005198"}],"value":"Lipid metabolism; mitochondrial fatty acid beta-oxidation"}],"commentType":"PATHWAY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00011881"}],"value":"Homotetramer"}],"commentType":"SUBUNIT"},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004305"}],"value":"Mitochondrion matrix","id":"SL-0170"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00009347"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU362125"}],"value":"Belongs to the acyl-CoA dehydrogenase family"}],"commentType":"SIMILARITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"NXE19758.1"}],"value":"The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data"}],"commentType":"CAUTION"}],"features":[{"type":"Domain","location":{"start":{"value":32,"modifier":"EXACT"},"end":{"value":142,"modifier":"EXACT"}},"description":"Acyl-CoA dehydrogenase/oxidase N-terminal","evidences":[{"evidenceCode":"ECO:0000259","source":"Pfam","id":"PF02771"}]},{"type":"Domain","location":{"start":{"value":146,"modifier":"EXACT"},"end":{"value":243,"modifier":"EXACT"}},"description":"Acyl-CoA dehydrogenase/oxidase middle","evidences":[{"evidenceCode":"ECO:0000259","source":"Pfam","id":"PF02770"}]},{"type":"Domain","location":{"start":{"value":255,"modifier":"EXACT"},"end":{"value":403,"modifier":"EXACT"}},"description":"Acyl-CoA dehydrogenase/oxidase C-terminal","evidences":[{"evidenceCode":"ECO:0000259","source":"Pfam","id":"PF00441"}]},{"type":"Non-terminal residue","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":1,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"NXE19758.1"}]},{"type":"Non-terminal residue","location":{"start":{"value":407,"modifier":"EXACT"},"end":{"value":407,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"NXE19758.1"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022990"}],"id":"KW-0007","category":"PTM","name":"Acetylation"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022827"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU362125"}],"id":"KW-0274","category":"Ligand","name":"FAD"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022832"}],"id":"KW-0276","category":"Biological process","name":"Fatty acid metabolism"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022630"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU362125"}],"id":"KW-0285","category":"Ligand","name":"Flavoprotein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023098"}],"id":"KW-0443","category":"Biological process","name":"Lipid metabolism"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023128"}],"id":"KW-0496","category":"Cellular component","name":"Mitochondrion"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023002"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU362125"}],"id":"KW-0560","category":"Molecular function","name":"Oxidoreductase"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022553"}],"id":"KW-0597","category":"PTM","name":"Phosphoprotein"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000560386"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022946"}],"id":"KW-0809","category":"Domain","name":"Transit peptide"}],"references":[{"referenceNumber":1,"citation":{"id":"CI-90S2KOISV381S","citationType":"submission","authors":["Zhang G."],"title":"Bird 10,000 Genomes (B10K) Project - Family phase.","publicationDate":"SEP-2019","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"NXE19758.1"}],"value":"B10K-CU-031-01","type":"STRAIN"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"NXE19758.1"}],"value":"Muscle","type":"TISSUE"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"NXE19758.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000560386"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"VWPR01000098","properties":[{"key":"ProteinId","value":"NXE19758.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"AlphaFoldDB","id":"A0A7K8KRN4","properties":[{"key":"Description","value":"-"}]},{"database":"UniPathway","id":"UPA00660","properties":[{"key":"RectionId","value":"-"}]},{"database":"Proteomes","id":"UP000560386","properties":[{"key":"Component","value":"Unassembled WGS sequence"}]},{"database":"GO","id":"GO:0005759","properties":[{"key":"GoTerm","value":"C:mitochondrial matrix"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0050660","properties":[{"key":"GoTerm","value":"F:flavin adenine dinucleotide binding"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0004466","properties":[{"key":"GoTerm","value":"F:long-chain fatty acyl-CoA dehydrogenase activity"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-EC"}]},{"database":"GO","id":"GO:0070991","properties":[{"key":"GoTerm","value":"F:medium-chain fatty acyl-CoA dehydrogenase activity"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-EC"}]},{"database":"GO","id":"GO:0019254","properties":[{"key":"GoTerm","value":"P:carnitine metabolic process, CoA-linked"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:0033539","properties":[{"key":"GoTerm","value":"P:fatty acid beta-oxidation using acyl-CoA dehydrogenase"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:0042758","properties":[{"key":"GoTerm","value":"P:long-chain fatty acid catabolic process"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"CDD","id":"cd01160","properties":[{"key":"EntryName","value":"LCAD"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.40.110.10:FF:000002","properties":[{"key":"EntryName","value":"Acyl-CoA dehydrogenase fadE12"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.10.540.10:FF:000017","properties":[{"key":"EntryName","value":"long-chain specific acyl-CoA dehydrogenase, mitochondrial"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.140.10:FF:000020","properties":[{"key":"EntryName","value":"Long-chain specific acyl-CoA dehydrogenase, mitochondrial"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.10.540.10","properties":[{"key":"EntryName","value":"Acyl-CoA dehydrogenase/oxidase, N-terminal domain"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.40.110.10","properties":[{"key":"EntryName","value":"Butyryl-CoA Dehydrogenase, subunit A, domain 2"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.20.140.10","properties":[{"key":"EntryName","value":"Butyryl-CoA Dehydrogenase, subunit A, domain 3"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR006089","properties":[{"key":"EntryName","value":"Acyl-CoA_DH_CS"}]},{"database":"InterPro","id":"IPR046373","properties":[{"key":"EntryName","value":"Acyl-CoA_Oxase/DH_mid-dom_sf"}]},{"database":"InterPro","id":"IPR036250","properties":[{"key":"EntryName","value":"AcylCo_DH-like_C"}]},{"database":"InterPro","id":"IPR009075","properties":[{"key":"EntryName","value":"AcylCo_DH/oxidase_C"}]},{"database":"InterPro","id":"IPR006091","properties":[{"key":"EntryName","value":"AcylCoA_DH/ox_M"}]},{"database":"InterPro","id":"IPR013786","properties":[{"key":"EntryName","value":"AcylCoA_DH/ox_N"}]},{"database":"InterPro","id":"IPR037069","properties":[{"key":"EntryName","value":"AcylCoA_DH/ox_N_sf"}]},{"database":"InterPro","id":"IPR009100","properties":[{"key":"EntryName","value":"AcylCoA_DH/oxidase_NM_dom_sf"}]},{"database":"InterPro","id":"IPR034179","properties":[{"key":"EntryName","value":"LCAD"}]},{"database":"PANTHER","id":"PTHR48083:SF20","properties":[{"key":"EntryName","value":"LONG-CHAIN SPECIFIC ACYL-COA DEHYDROGENASE, MITOCHONDRIAL"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR48083","properties":[{"key":"EntryName","value":"MEDIUM-CHAIN SPECIFIC ACYL-COA DEHYDROGENASE, MITOCHONDRIAL-RELATED"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00441","properties":[{"key":"EntryName","value":"Acyl-CoA_dh_1"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF02770","properties":[{"key":"EntryName","value":"Acyl-CoA_dh_M"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF02771","properties":[{"key":"EntryName","value":"Acyl-CoA_dh_N"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF47203","properties":[{"key":"EntryName","value":"Acyl-CoA dehydrogenase C-terminal domain-like"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF56645","properties":[{"key":"EntryName","value":"Acyl-CoA dehydrogenase NM domain-like"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00072","properties":[{"key":"EntryName","value":"ACYL_COA_DH_1"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00073","properties":[{"key":"EntryName","value":"ACYL_COA_DH_2"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"SPLQTEQHGTKRPEPSSARSLIDIGTRRIFSSEHDIFRESARKFFQEEVLPFHAEWEKDGQVSRELWEKAGQQGLLGVAIAEKHGGIGADILSSAVVWEEQMYVNCTGPGFSLHSDIVMPYIANYGSEEQIKRFIPEMIAGKCIGAIAMTEPGAGSDLQGIRTYAKKDGSDWILNGSKVFITNGWMSDVVIVVAVTNREARSPAHGISLFLVENGTKGFIKGRKLHKIGLKAQDTAELFFEDVRLPASALLGKENKGFYYLMAELPQERLLIADMALAGCEFMFEETRNYVKQRKAFGKTIAHLQTVQHKLAEMKTQICVGRAFMDNCLQLHADKRLDSSTASMAKYWCSDLQNSIATQCVQLHGGWGYMWEYPIAKAFVDARVQPIYGGTNEIMKELIARDIVSDK","length":407,"molWeight":45435,"crc64":"A684BE2901DA7EDF","md5":"E5EC38053B67652EB905C5572BD1A5BF"},"extraAttributes":{"countByCommentType":{"CATALYTIC ACTIVITY":43,"COFACTOR":1,"PATHWAY":1,"SUBUNIT":1,"SUBCELLULAR LOCATION":1,"SIMILARITY":1,"CAUTION":1},"countByFeatureType":{"Domain":3,"Non-terminal residue":2},"uniParcId":"UPI00180B843E"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0A7K8KT01","uniProtkbId":"A0A7K8KT01_9AVES","entryAudit":{"firstPublicDate":"2021-04-07","lastAnnotationUpdateDate":"2026-11-04","lastSequenceUpdateDate":"2021-04-07","entryVersion":24,"sequenceVersion":1},"annotationScore":5.0,"organism":{"scientificName":"Ardeotis kori","taxonId":89386,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"NXE19552.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000560386"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Archelosauria","Archosauria","Dinosauria","Saurischia","Theropoda","Coelurosauria","Aves","Neognathae","Neoaves","Otidimorphae","Otidiformes","Otididae","Ardeotis"]},"proteinExistence":"3: Inferred from homology","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00067125"}],"value":"Lysine-specific histone demethylase 1A"},"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00038951"}],"value":"1.14.11.65"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00066706"}],"value":"1.14.99.66"}]},"alternativeNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00082642"}],"value":"BRAF35-HDAC complex protein BHC110"}}],"flag":"Fragment"},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"NXE19552.1"}],"value":"Kdm1a"},"orfNames":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"NXE19552.1"}],"value":"ARDKOR_R10419"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00094488"}],"value":"Neuron-specific histone demethylase that demethylates mono- and dimethylated 'Lys-20' of histone H4 (H4K20me1 and H4K20me2), a chromatin repressive mark. This demethylation is crucial for the initiation and elongation of neuronal activity-regulated genes, required for spatial learning and memory. Mediates H3K9me2 demethylation through cooperation with the supervillin protein (SVIL), and this H3K9 demethylase activity is essential for regulating gene expression during neuronal differentiation"}],"commentType":"FUNCTION"},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"N(6),N(6)-dimethyl-L-lysyl(20)-[histone H4] + 2-oxoglutarate + O2 = N(6)-methyl-L-lysyl(20)-[histone H4] + formaldehyde + succinate + CO2","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:85907"},{"database":"Rhea","id":"RHEA-COMP:15555"},{"database":"Rhea","id":"RHEA-COMP:15556"},{"database":"ChEBI","id":"CHEBI:15379"},{"database":"ChEBI","id":"CHEBI:16526"},{"database":"ChEBI","id":"CHEBI:16810"},{"database":"ChEBI","id":"CHEBI:16842"},{"database":"ChEBI","id":"CHEBI:30031"},{"database":"ChEBI","id":"CHEBI:61929"},{"database":"ChEBI","id":"CHEBI:61976"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00094019"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:85908"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00094019"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"N(6),N(6)-dimethyl-L-lysyl(4)-[histone H3] + 2 A + 2 H2O = L-lysyl(4)-[histone H3] + 2 formaldehyde + 2 AH2","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:60244"},{"database":"Rhea","id":"RHEA-COMP:15540"},{"database":"Rhea","id":"RHEA-COMP:15547"},{"database":"ChEBI","id":"CHEBI:13193"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:16842"},{"database":"ChEBI","id":"CHEBI:17499"},{"database":"ChEBI","id":"CHEBI:29969"},{"database":"ChEBI","id":"CHEBI:61976"}],"ecNumber":"1.14.99.66","evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00051715"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:60245"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00051715"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"N(6),N(6)-dimethyl-L-lysyl(4)-[histone H3] + A + H2O = N(6)-methyl-L-lysyl(4)-[histone H3] + formaldehyde + AH2","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:60248"},{"database":"Rhea","id":"RHEA-COMP:15540"},{"database":"Rhea","id":"RHEA-COMP:15543"},{"database":"ChEBI","id":"CHEBI:13193"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:16842"},{"database":"ChEBI","id":"CHEBI:17499"},{"database":"ChEBI","id":"CHEBI:61929"},{"database":"ChEBI","id":"CHEBI:61976"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00093955"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:60249"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00093955"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"N(6),N(6)-dimethyl-L-lysyl(9)-[histone H3] + 2 2-oxoglutarate + 2 O2 = L-lysyl(9)-[histone H3] + 2 formaldehyde + 2 succinate + 2 CO2","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:60188"},{"database":"Rhea","id":"RHEA-COMP:15541"},{"database":"Rhea","id":"RHEA-COMP:15546"},{"database":"ChEBI","id":"CHEBI:15379"},{"database":"ChEBI","id":"CHEBI:16526"},{"database":"ChEBI","id":"CHEBI:16810"},{"database":"ChEBI","id":"CHEBI:16842"},{"database":"ChEBI","id":"CHEBI:29969"},{"database":"ChEBI","id":"CHEBI:30031"},{"database":"ChEBI","id":"CHEBI:61976"}],"ecNumber":"1.14.11.65","evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00051254"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:60189"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00051254"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"N(6),N(6)-dimethyl-L-lysyl(9)-[histone H3] + 2-oxoglutarate + O2 = N(6)-methyl-L-lysyl(9)-[histone H3] + formaldehyde + succinate + CO2","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:60192"},{"database":"Rhea","id":"RHEA-COMP:15541"},{"database":"Rhea","id":"RHEA-COMP:15542"},{"database":"ChEBI","id":"CHEBI:15379"},{"database":"ChEBI","id":"CHEBI:16526"},{"database":"ChEBI","id":"CHEBI:16810"},{"database":"ChEBI","id":"CHEBI:16842"},{"database":"ChEBI","id":"CHEBI:30031"},{"database":"ChEBI","id":"CHEBI:61929"},{"database":"ChEBI","id":"CHEBI:61976"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00053001"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:60193"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00053001"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"N(6)-methyl-L-lysyl(20)-[histone H4] + 2-oxoglutarate + O2 = L-lysyl(20)-[histone H4] + formaldehyde + succinate + CO2","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:67804"},{"database":"Rhea","id":"RHEA-COMP:15554"},{"database":"Rhea","id":"RHEA-COMP:15555"},{"database":"ChEBI","id":"CHEBI:15379"},{"database":"ChEBI","id":"CHEBI:16526"},{"database":"ChEBI","id":"CHEBI:16810"},{"database":"ChEBI","id":"CHEBI:16842"},{"database":"ChEBI","id":"CHEBI:29969"},{"database":"ChEBI","id":"CHEBI:30031"},{"database":"ChEBI","id":"CHEBI:61929"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00050318"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:67805"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00050318"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"N(6)-methyl-L-lysyl(4)-[histone H3] + A + H2O = L-lysyl(4)-[histone H3] + formaldehyde + AH2","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:60256"},{"database":"Rhea","id":"RHEA-COMP:15543"},{"database":"Rhea","id":"RHEA-COMP:15547"},{"database":"ChEBI","id":"CHEBI:13193"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:16842"},{"database":"ChEBI","id":"CHEBI:17499"},{"database":"ChEBI","id":"CHEBI:29969"},{"database":"ChEBI","id":"CHEBI:61929"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00051126"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:60257"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00051126"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"N(6)-methyl-L-lysyl(9)-[histone H3] + 2-oxoglutarate + O2 = L-lysyl(9)-[histone H3] + formaldehyde + succinate + CO2","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:60196"},{"database":"Rhea","id":"RHEA-COMP:15542"},{"database":"Rhea","id":"RHEA-COMP:15546"},{"database":"ChEBI","id":"CHEBI:15379"},{"database":"ChEBI","id":"CHEBI:16526"},{"database":"ChEBI","id":"CHEBI:16810"},{"database":"ChEBI","id":"CHEBI:16842"},{"database":"ChEBI","id":"CHEBI:29969"},{"database":"ChEBI","id":"CHEBI:30031"},{"database":"ChEBI","id":"CHEBI:61929"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00094046"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:60197"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00094046"}]}]},{"commentType":"COFACTOR","cofactors":[{"name":"FAD","evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00001974"},{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR038051-1"}],"cofactorCrossReference":{"database":"ChEBI","id":"CHEBI:57692"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00094641"}],"value":"Component of a histone demethylase complex with RCOR1. Forms a complex with SVIL, which functions to demethylate histone H3 at Lys-9 (H3K9me2)"}],"commentType":"SUBUNIT"},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004286"}],"value":"Chromosome","id":"SL-0468"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004123"}],"value":"Nucleus","id":"SL-0191"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00005995"}],"value":"Belongs to the flavin monoamine oxidase family"}],"commentType":"SIMILARITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"NXE19552.1"}],"value":"The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data"}],"commentType":"CAUTION"}],"features":[{"type":"Domain","location":{"start":{"value":80,"modifier":"EXACT"},"end":{"value":179,"modifier":"EXACT"}},"description":"SWIRM","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50934"}]},{"type":"Region","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":81,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Coiled coil","location":{"start":{"value":340,"modifier":"EXACT"},"end":{"value":374,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Coils"}]},{"type":"Compositional bias","location":{"start":{"value":22,"modifier":"EXACT"},"end":{"value":35,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":44,"modifier":"EXACT"},"end":{"value":54,"modifier":"EXACT"}},"description":"Acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":68,"modifier":"EXACT"},"end":{"value":80,"modifier":"EXACT"}},"description":"Gly residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Binding site","location":{"start":{"value":187,"modifier":"EXACT"},"end":{"value":215,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:57692"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR038051-1"}],"ligand":{"name":"FAD","id":"ChEBI:CHEBI:57692"}},{"type":"Binding site","location":{"start":{"value":216,"modifier":"EXACT"},"end":{"value":216,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:57692"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR038051-1"}],"ligand":{"name":"FAD","id":"ChEBI:CHEBI:57692"}},{"type":"Binding site","location":{"start":{"value":222,"modifier":"EXACT"},"end":{"value":222,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:57692"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR038051-1"}],"ligand":{"name":"FAD","id":"ChEBI:CHEBI:57692"}},{"type":"Binding site","location":{"start":{"value":238,"modifier":"EXACT"},"end":{"value":239,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:57692"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR038051-1"}],"ligand":{"name":"FAD","id":"ChEBI:CHEBI:57692"}},{"type":"Binding site","location":{"start":{"value":707,"modifier":"EXACT"},"end":{"value":707,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:57692"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR038051-1"}],"ligand":{"name":"FAD","id":"ChEBI:CHEBI:57692"}},{"type":"Binding site","location":{"start":{"value":716,"modifier":"EXACT"},"end":{"value":717,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:57692"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR038051-1"}],"ligand":{"name":"FAD","id":"ChEBI:CHEBI:57692"}},{"type":"Non-terminal residue","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":1,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"NXE19552.1"}]},{"type":"Non-terminal residue","location":{"start":{"value":758,"modifier":"EXACT"},"end":{"value":758,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"NXE19552.1"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022990"}],"id":"KW-0007","category":"PTM","name":"Acetylation"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022853"}],"id":"KW-0156","category":"Molecular function","name":"Chromatin regulator"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022454"}],"id":"KW-0158","category":"Cellular component","name":"Chromosome"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023054"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"Coils"}],"id":"KW-0175","category":"Domain","name":"Coiled coil"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022473"}],"id":"KW-0217","category":"Molecular function","name":"Developmental protein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022827"},{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR038051-1"}],"id":"KW-0274","category":"Ligand","name":"FAD"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022630"}],"id":"KW-0285","category":"Ligand","name":"Flavoprotein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022499"}],"id":"KW-1017","category":"PTM","name":"Isopeptide bond"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"NXE19552.1"}],"id":"KW-0489","category":"Molecular function","name":"Methyltransferase"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023242"}],"id":"KW-0539","category":"Cellular component","name":"Nucleus"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023002"}],"id":"KW-0560","category":"Molecular function","name":"Oxidoreductase"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022553"}],"id":"KW-0597","category":"PTM","name":"Phosphoprotein"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000560386"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022491"}],"id":"KW-0678","category":"Molecular function","name":"Repressor"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023163"}],"id":"KW-0804","category":"Biological process","name":"Transcription"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023015"}],"id":"KW-0805","category":"Biological process","name":"Transcription regulation"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"NXE19552.1"}],"id":"KW-0808","category":"Molecular function","name":"Transferase"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022843"}],"id":"KW-0832","category":"PTM","name":"Ubl conjugation"}],"references":[{"referenceNumber":1,"citation":{"id":"CI-90S2KOISV381S","citationType":"submission","authors":["Zhang G."],"title":"Bird 10,000 Genomes (B10K) Project - Family phase.","publicationDate":"SEP-2019","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"NXE19552.1"}],"value":"B10K-CU-031-01","type":"STRAIN"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"NXE19552.1"}],"value":"Muscle","type":"TISSUE"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"NXE19552.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000560386"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"VWPR01000084","properties":[{"key":"ProteinId","value":"NXE19552.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"AlphaFoldDB","id":"A0A7K8KT01","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000560386","properties":[{"key":"Component","value":"Unassembled WGS sequence"}]},{"database":"GO","id":"GO:0000785","properties":[{"key":"GoTerm","value":"C:chromatin"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0005634","properties":[{"key":"GoTerm","value":"C:nucleus"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0003682","properties":[{"key":"GoTerm","value":"F:chromatin binding"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0019899","properties":[{"key":"GoTerm","value":"F:enzyme binding"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0140682","properties":[{"key":"GoTerm","value":"F:FAD-dependent H3K4me/H3K4me3 demethylase activity"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-EC"}]},{"database":"GO","id":"GO:0050660","properties":[{"key":"GoTerm","value":"F:flavin adenine dinucleotide binding"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0140683","properties":[{"key":"GoTerm","value":"F:histone H3K9me/H3K9me2 demethylase activity"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-EC"}]},{"database":"GO","id":"GO:0043426","properties":[{"key":"GoTerm","value":"F:MRF binding"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0003723","properties":[{"key":"GoTerm","value":"F:RNA binding"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0061629","properties":[{"key":"GoTerm","value":"F:RNA polymerase II-specific DNA-binding transcription factor binding"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0003713","properties":[{"key":"GoTerm","value":"F:transcription coactivator activity"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0003714","properties":[{"key":"GoTerm","value":"F:transcription corepressor activity"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0140861","properties":[{"key":"GoTerm","value":"P:DNA repair-dependent chromatin remodeling"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0000122","properties":[{"key":"GoTerm","value":"P:negative regulation of transcription by RNA polymerase II"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0048666","properties":[{"key":"GoTerm","value":"P:neuron development"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0045597","properties":[{"key":"GoTerm","value":"P:positive regulation of cell differentiation"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0051240","properties":[{"key":"GoTerm","value":"P:positive regulation of multicellular organismal process"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:2000179","properties":[{"key":"GoTerm","value":"P:positive regulation of neural precursor cell proliferation"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0045944","properties":[{"key":"GoTerm","value":"P:positive regulation of transcription by RNA polymerase II"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0050767","properties":[{"key":"GoTerm","value":"P:regulation of neurogenesis"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"FunFam","id":"3.50.50.60:FF:000027","properties":[{"key":"EntryName","value":"Lysine-specific histone demethylase"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.50.50.60:FF:000029","properties":[{"key":"EntryName","value":"Lysine-specific histone demethylase"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.90.660.10:FF:000001","properties":[{"key":"EntryName","value":"Lysine-specific histone demethylase"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.10.10.10:FF:000064","properties":[{"key":"EntryName","value":"Lysine-specific histone demethylase 1A"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.10.287.80:FF:000002","properties":[{"key":"EntryName","value":"Lysine-specific histone demethylase 1A"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.90.660.10","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.10.287.80","properties":[{"key":"EntryName","value":"ATP synthase, gamma subunit, helix hairpin domain"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.50.50.60","properties":[{"key":"EntryName","value":"FAD/NAD(P)-binding domain"},{"key":"MatchStatus","value":"2"}]},{"database":"Gene3D","id":"1.10.10.10","properties":[{"key":"EntryName","value":"Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR002937","properties":[{"key":"EntryName","value":"Amino_oxidase"}]},{"database":"InterPro","id":"IPR036188","properties":[{"key":"EntryName","value":"FAD/NAD-bd_sf"}]},{"database":"InterPro","id":"IPR017366","properties":[{"key":"EntryName","value":"Hist_Lys-spec_deMease"}]},{"database":"InterPro","id":"IPR009057","properties":[{"key":"EntryName","value":"Homeodomain-like_sf"}]},{"database":"InterPro","id":"IPR050281","properties":[{"key":"EntryName","value":"L-amino-acid_oxidase-like"}]},{"database":"InterPro","id":"IPR007526","properties":[{"key":"EntryName","value":"SWIRM"}]},{"database":"InterPro","id":"IPR036388","properties":[{"key":"EntryName","value":"WH-like_DNA-bd_sf"}]},{"database":"PANTHER","id":"PTHR10742","properties":[{"key":"EntryName","value":"FLAVIN MONOAMINE OXIDASE"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR10742:SF386","properties":[{"key":"EntryName","value":"LYSINE-SPECIFIC HISTONE DEMETHYLASE 1A"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF01593","properties":[{"key":"EntryName","value":"Amino_oxidase"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF04433","properties":[{"key":"EntryName","value":"SWIRM"},{"key":"MatchStatus","value":"1"}]},{"database":"PIRSF","id":"PIRSF038051","properties":[{"key":"EntryName","value":"Histone_Lys-demethylase"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF54373","properties":[{"key":"EntryName","value":"FAD-linked reductases, C-terminal domain"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF51905","properties":[{"key":"EntryName","value":"FAD/NAD(P)-binding domain"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF46689","properties":[{"key":"EntryName","value":"Homeodomain-like"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50934","properties":[{"key":"EntryName","value":"SWIRM"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"QVEYREMDESLANLSEDEYYSEEERNAKAEKEKKLPPPPPPAPAEEENESEPEEPSGQAGGLQDDNSGGYGDGQASGEGVEGAAFQSRLPHDRMTSQEAACFPDIISGPQQTQKVFLYIRNRTLQLWLDNPKIQLTFEATIQQLEAPYNSDTVLVHRVHSYLERHGLINFGIYKRVKPLPTKKTGKVIIIGSGVSGLAAARQLQSFGMDVTVLEARDRVGGRVATFRKGNYVADLGAMVVTGLGGNPMAVVSKQVNMELAKIKQKCPLYEANGQAVPKEKDEMVEQEFNRLLEATSYLSHQLDFNVLNNKPVSLGQALEVVIQLQEKHVKDEQIEHWKKIVKTQEELKDLLNKMVNLKEKIKELHQQYKEASEVKPPRDITAEFLVKSKHRDLTALCKEYDELAETQGKLEEKLQELEANPPSDVYLSSRDRQILDWHFANLEFANATPLSTLSLKHWDQDDDFEFTGSHLTVRNGYSCVPVALAEGLDIKLNTAVRQVRYTASGCEVIAVNTRSTSQTFIYKCDAVLCTLPLGVLKQQPPAVQFVPPLPEWKTSAVQRMGFGNLNKVVLCFDRVFWDPSVNLFGHVGSTTASRGELFLFWNLYKAPILLALVAGEAAGIMENISDDVIVGRCLAILKGIFGSSAVPQPKETVVSRWRADPWARGSYSYVAAGSSGNDYDLMAQPITPGPAIPGAPQPIPRLFFAGEHTIRNYPATVHGALLSGLREAGRIADQFLGAMYTLPRQPTPGVPPQQAASM","length":758,"molWeight":83923,"crc64":"9614974A505BC390","md5":"54F41C3B42C137400B36832442A5D86A"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"CATALYTIC ACTIVITY":8,"COFACTOR":1,"SUBUNIT":1,"SUBCELLULAR LOCATION":1,"SIMILARITY":1,"CAUTION":1},"countByFeatureType":{"Domain":1,"Region":1,"Coiled coil":1,"Compositional bias":3,"Binding site":6,"Non-terminal residue":2},"uniParcId":"UPI0017A85155"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0A7K8KT41","uniProtkbId":"A0A7K8KT41_9AVES","entryAudit":{"firstPublicDate":"2021-04-07","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2021-04-07","entryVersion":25,"sequenceVersion":1},"annotationScore":5.0,"organism":{"scientificName":"Ardeotis kori","taxonId":89386,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"NXE17744.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000560386"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Archelosauria","Archosauria","Dinosauria","Saurischia","Theropoda","Coelurosauria","Aves","Neognathae","Neoaves","Otidimorphae","Otidiformes","Otididae","Ardeotis"]},"proteinExistence":"3: Inferred from homology","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00069069"}],"value":"Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform"},"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00012073"}],"value":"2.7.1.137"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00012010"}],"value":"2.7.1.153"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00012013"}],"value":"2.7.1.154"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00012513"}],"value":"2.7.11.1"}]},"alternativeNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00083126"}],"value":"Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit gamma"}},{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00080619"}],"value":"Phosphoinositide-3-kinase catalytic gamma polypeptide"}},{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00076130"}],"value":"Serine/threonine protein kinase PIK3CG"}},{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00078766"}],"value":"p120-PI3K"}}],"flag":"Fragment"},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"NXE17744.1"}],"value":"Pik3cg"},"orfNames":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"NXE17744.1"}],"value":"ARDKOR_R04701"}]}],"comments":[{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:17989"},{"database":"Rhea","id":"RHEA-COMP:9863"},{"database":"Rhea","id":"RHEA-COMP:11604"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:29999"},{"database":"ChEBI","id":"CHEBI:30616"},{"database":"ChEBI","id":"CHEBI:83421"},{"database":"ChEBI","id":"CHEBI:456216"}],"ecNumber":"2.7.11.1","evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00048977"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:17990"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00048977"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4-bisphosphate) + ADP + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:18373"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:30616"},{"database":"ChEBI","id":"CHEBI:57658"},{"database":"ChEBI","id":"CHEBI:58178"},{"database":"ChEBI","id":"CHEBI:456216"}],"ecNumber":"2.7.1.154","evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00029297"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:18374"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00029297"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + ADP + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:12709"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:30616"},{"database":"ChEBI","id":"CHEBI:57880"},{"database":"ChEBI","id":"CHEBI:58088"},{"database":"ChEBI","id":"CHEBI:456216"}],"ecNumber":"2.7.1.137","evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023985"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:12710"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023985"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + ADP + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:21292"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:30616"},{"database":"ChEBI","id":"CHEBI:57836"},{"database":"ChEBI","id":"CHEBI:58456"},{"database":"ChEBI","id":"CHEBI:456216"}],"ecNumber":"2.7.1.153","evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023981"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:21293"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023981"}]}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00005189"}],"value":"Lipid metabolism"}],"commentType":"PATHWAY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004805"}],"value":"Phospholipid metabolism; phosphatidylinositol phosphate biosynthesis"}],"commentType":"PATHWAY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00063154"}],"value":"Heterodimer of a catalytic subunit PIK3CG and a PIK3R5 or PIK3R6 regulatory subunit. Interacts with GRK2 through the PIK helical domain. Interaction with GRK2 is required for targeting to agonist-occupied receptor. Interacts with PDE3B; regulates PDE3B activity and thereby cAMP levels in cells. Interacts with TPM2. Interacts with EPHA8; regulates integrin-mediated cell adhesion to substrate. Interacts with HRAS; the interaction is required for membrane recruitment and beta-gamma G protein dimer-dependent activation of the PI3K gamma complex PIK3CG:PIK3R6"}],"commentType":"SUBUNIT"},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004236"}],"value":"Cell membrane","id":"SL-0039"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004496"}],"value":"Cytoplasm","id":"SL-0086"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00006209"}],"value":"Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily"}],"commentType":"SIMILARITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00269"}],"value":"Lacks conserved residue(s) required for the propagation of feature annotation"}],"commentType":"CAUTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"NXE17744.1"}],"value":"The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data"}],"commentType":"CAUTION"}],"features":[{"type":"Domain","location":{"start":{"value":34,"modifier":"EXACT"},"end":{"value":141,"modifier":"EXACT"}},"description":"PI3K-ABD","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS51544"}]},{"type":"Domain","location":{"start":{"value":217,"modifier":"EXACT"},"end":{"value":309,"modifier":"EXACT"}},"description":"PI3K-RBD","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS51546"}]},{"type":"Domain","location":{"start":{"value":357,"modifier":"EXACT"},"end":{"value":524,"modifier":"EXACT"}},"description":"C2 PI3K-type","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS51547"}]},{"type":"Domain","location":{"start":{"value":544,"modifier":"EXACT"},"end":{"value":726,"modifier":"EXACT"}},"description":"PIK helical","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS51545"}]},{"type":"Domain","location":{"start":{"value":800,"modifier":"EXACT"},"end":{"value":1083,"modifier":"EXACT"}},"description":"PI3K/PI4K catalytic","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50290"}]},{"type":"Region","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":26,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":806,"modifier":"EXACT"},"end":{"value":812,"modifier":"EXACT"}},"description":"G-loop","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00269"}]},{"type":"Region","location":{"start":{"value":946,"modifier":"EXACT"},"end":{"value":954,"modifier":"EXACT"}},"description":"Catalytic loop","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00269"}]},{"type":"Non-terminal residue","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":1,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"NXE17744.1"}]},{"type":"Non-terminal residue","location":{"start":{"value":1106,"modifier":"EXACT"},"end":{"value":1106,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"NXE17744.1"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022657"}],"id":"KW-0037","category":"Biological process","name":"Angiogenesis"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022840"}],"id":"KW-0067","category":"Ligand","name":"ATP-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022475"}],"id":"KW-1003","category":"Cellular component","name":"Cell membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022500"}],"id":"KW-0145","category":"Biological process","name":"Chemotaxis"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022490"}],"id":"KW-0963","category":"Cellular component","name":"Cytoplasm"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022583"}],"id":"KW-0254","category":"Biological process","name":"Endocytosis"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022859"}],"id":"KW-0391","category":"Biological process","name":"Immunity"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023198"}],"id":"KW-0395","category":"Biological process","name":"Inflammatory response"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022777"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00269"}],"id":"KW-0418","category":"Molecular function","name":"Kinase"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023098"}],"id":"KW-0443","category":"Biological process","name":"Lipid metabolism"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023136"}],"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022741"}],"id":"KW-0547","category":"Ligand","name":"Nucleotide-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022553"}],"id":"KW-0597","category":"PTM","name":"Phosphoprotein"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000560386"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022527"}],"id":"KW-0723","category":"Molecular function","name":"Serine/threonine-protein kinase"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022679"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00269"}],"id":"KW-0808","category":"Molecular function","name":"Transferase"}],"references":[{"referenceNumber":1,"citation":{"id":"CI-90S2KOISV381S","citationType":"submission","authors":["Zhang G."],"title":"Bird 10,000 Genomes (B10K) Project - Family phase.","publicationDate":"SEP-2019","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"NXE17744.1"}],"value":"B10K-CU-031-01","type":"STRAIN"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"NXE17744.1"}],"value":"Muscle","type":"TISSUE"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"NXE17744.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000560386"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"VWPR01000010","properties":[{"key":"ProteinId","value":"NXE17744.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"AlphaFoldDB","id":"A0A7K8KT41","properties":[{"key":"Description","value":"-"}]},{"database":"UniPathway","id":"UPA00220","properties":[{"key":"RectionId","value":"-"}]},{"database":"Proteomes","id":"UP000560386","properties":[{"key":"Component","value":"Unassembled WGS sequence"}]},{"database":"GO","id":"GO:0005737","properties":[{"key":"GoTerm","value":"C:cytoplasm"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0005943","properties":[{"key":"GoTerm","value":"C:phosphatidylinositol 3-kinase complex, class IA"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:0005944","properties":[{"key":"GoTerm","value":"C:phosphatidylinositol 3-kinase complex, class IB"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:0005886","properties":[{"key":"GoTerm","value":"C:plasma membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0016303","properties":[{"key":"GoTerm","value":"F:1-phosphatidylinositol-3-kinase activity"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-EC"}]},{"database":"GO","id":"GO:0046934","properties":[{"key":"GoTerm","value":"F:1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-EC"}]},{"database":"GO","id":"GO:0035005","properties":[{"key":"GoTerm","value":"F:1-phosphatidylinositol-4-phosphate 3-kinase activity"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-EC"}]},{"database":"GO","id":"GO:0004674","properties":[{"key":"GoTerm","value":"F:protein serine/threonine kinase activity"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-EC"}]},{"database":"GO","id":"GO:0016477","properties":[{"key":"GoTerm","value":"P:cell migration"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:0043491","properties":[{"key":"GoTerm","value":"P:phosphatidylinositol 3-kinase/protein kinase B signal transduction"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:0048015","properties":[{"key":"GoTerm","value":"P:phosphatidylinositol-mediated signaling"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniRule"}]},{"database":"GO","id":"GO:0010595","properties":[{"key":"GoTerm","value":"P:positive regulation of endothelial cell migration"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0035022","properties":[{"key":"GoTerm","value":"P:positive regulation of Rac protein signal transduction"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0003376","properties":[{"key":"GoTerm","value":"P:sphingosine-1-phosphate receptor signaling pathway"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"CDD","id":"cd08399","properties":[{"key":"EntryName","value":"C2_PI3K_class_I_gamma"},{"key":"MatchStatus","value":"1"}]},{"database":"CDD","id":"cd00872","properties":[{"key":"EntryName","value":"PI3Ka_I"},{"key":"MatchStatus","value":"1"}]},{"database":"CDD","id":"cd00894","properties":[{"key":"EntryName","value":"PI3Kc_IB_gamma"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.30.1010.10:FF:000008","properties":[{"key":"EntryName","value":"Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.10.1070.11:FF:000010","properties":[{"key":"EntryName","value":"Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.25.40.70:FF:000006","properties":[{"key":"EntryName","value":"Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.60.40.150:FF:000087","properties":[{"key":"EntryName","value":"Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.10.20.770:FF:000001","properties":[{"key":"EntryName","value":"Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.10.20.770","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.60.40.150","properties":[{"key":"EntryName","value":"C2 domain"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.10.1070.11","properties":[{"key":"EntryName","value":"Phosphatidylinositol 3-/4-kinase, catalytic domain"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.30.1010.10","properties":[{"key":"EntryName","value":"Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 4"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.25.40.70","properties":[{"key":"EntryName","value":"Phosphatidylinositol 3-kinase, accessory domain (PIK)"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR016024","properties":[{"key":"EntryName","value":"ARM-type_fold"}]},{"database":"InterPro","id":"IPR035892","properties":[{"key":"EntryName","value":"C2_domain_sf"}]},{"database":"InterPro","id":"IPR011009","properties":[{"key":"EntryName","value":"Kinase-like_dom_sf"}]},{"database":"InterPro","id":"IPR015433","properties":[{"key":"EntryName","value":"PI3/4_kinase"}]},{"database":"InterPro","id":"IPR000403","properties":[{"key":"EntryName","value":"PI3/4_kinase_cat_dom"}]},{"database":"InterPro","id":"IPR036940","properties":[{"key":"EntryName","value":"PI3/4_kinase_cat_sf"}]},{"database":"InterPro","id":"IPR018936","properties":[{"key":"EntryName","value":"PI3/4_kinase_CS"}]},{"database":"InterPro","id":"IPR002420","properties":[{"key":"EntryName","value":"PI3K-type_C2_dom"}]},{"database":"InterPro","id":"IPR003113","properties":[{"key":"EntryName","value":"PI3K_ABD"}]},{"database":"InterPro","id":"IPR001263","properties":[{"key":"EntryName","value":"PI3K_accessory_dom"}]},{"database":"InterPro","id":"IPR042236","properties":[{"key":"EntryName","value":"PI3K_accessory_sf"}]},{"database":"InterPro","id":"IPR000341","properties":[{"key":"EntryName","value":"PI3K_Ras-bd_dom"}]},{"database":"InterPro","id":"IPR045580","properties":[{"key":"EntryName","value":"PIK3CG_ABD"}]},{"database":"InterPro","id":"IPR029071","properties":[{"key":"EntryName","value":"Ubiquitin-like_domsf"}]},{"database":"PANTHER","id":"PTHR10048:SF34","properties":[{"key":"EntryName","value":"PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR10048","properties":[{"key":"EntryName","value":"PHOSPHATIDYLINOSITOL KINASE"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00454","properties":[{"key":"EntryName","value":"PI3_PI4_kinase"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00792","properties":[{"key":"EntryName","value":"PI3K_C2"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00794","properties":[{"key":"EntryName","value":"PI3K_rbd"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00613","properties":[{"key":"EntryName","value":"PI3Ka"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF19710","properties":[{"key":"EntryName","value":"PIK3CG_ABD"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00142","properties":[{"key":"EntryName","value":"PI3K_C2"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00144","properties":[{"key":"EntryName","value":"PI3K_rbd"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00145","properties":[{"key":"EntryName","value":"PI3Ka"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00146","properties":[{"key":"EntryName","value":"PI3Kc"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF48371","properties":[{"key":"EntryName","value":"ARM repeat"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF49562","properties":[{"key":"EntryName","value":"C2 domain (Calcium/lipid-binding domain, CaLB)"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF56112","properties":[{"key":"EntryName","value":"Protein kinase-like (PK-like)"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF54236","properties":[{"key":"EntryName","value":"Ubiquitin-like"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS51547","properties":[{"key":"EntryName","value":"C2_PI3K"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00915","properties":[{"key":"EntryName","value":"PI3_4_KINASE_1"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00916","properties":[{"key":"EntryName","value":"PI3_4_KINASE_2"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50290","properties":[{"key":"EntryName","value":"PI3_4_KINASE_3"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS51544","properties":[{"key":"EntryName","value":"PI3K_ABD"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS51546","properties":[{"key":"EntryName","value":"PI3K_RBD"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS51545","properties":[{"key":"EntryName","value":"PIK_HELICAL"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MELGDCEQPVVMREENKRRRRRMKPHCTSSNLSSMELISIEFILPTSNKHTKVPEMMLLEIAGNCTVEQMKAQIWMRAIEMSQTTEFYHTFTPDQFILQYQKKGQWYEIYDKHQVLQTLDCILYWKVLQKKVGKIYVVQKQKPSEEVQEFQRQLNDLIGYDVTDVSNVHDDELEFTRRRLVTPRMIEVACRDPKLYAMHPWTTSKPLPEYLFKKITNNNIFIIIHRGTTSQKIKVSIDDTPDMILHSFFTKMAKKKSLMDIPEDHSELDFVLRICGRDEYIIGETPIKDFHWIRQCLKNGEEIHLVLDNPPDPNEDEVQKEEWPLVDDCTGVTGYHEQLTIDGKDHERVFTISLWDCNRKFRVKIIGIDIPVLPRNTDLTVFVEANIQHGQQLLSQRRTSSKPFTEEVLWNIWLEFDIKIKDLPKGALLNLQIYCGKAQALSTKTNLQAHESPNSDSKCKTQLLYYVNLLLIDHRFLLRSGEYVLHMWKIPGKGEEQGSINADKLTSATNPDKENSMAISIVLDKYCHPIALPKHRITSDPQGDRTRAEMPNQLRKQLEEIIATDPLNPLSPEDKELLWHFRYESIKHPKAYPKLLSSVKWGQQEIVAKTYQLLAKKDVWDQSTLDVGLTLQLLDCNFSDENVRAMAVQKLESLEDDDVLHYLLQLVQAVKFEPYHDSALARFLLKRGLRNKRIGHFLFWFLRSEIAQSMHYQQRFAVILEAYLRGCGKAMLHDFMKQVQVIELLHKVTMEIKSVSAEKYDVTSQVIAQLRQKLEKLQNSKLPESFRVPYDPGLRAGALVIEKCKVMASKKKPLWLEFKCADPTALSNETIGIIFKHGDDLRQDMLILQILRIMESIWEAESLDLCLLPYGCISTGNKIGMIEIVKDATTIAKIQQSTVGNTGAFKDEILNQWLKERCMIEEKFQAAVERFVYSCAGYCVATFVLGIGDRHNDNIMITETGNLFHIDFGHILGNYKSFLGINKERVPFVLTPDFLFVMGTSGKKTSLHFHKFQDVCVKAYLALRHHTNLLIILFSMMLMTGMPQLTSKEDIEYIRDALTVGKSEEDAKKHFLDQIEVCRDKGWTVQFNWFLHLVLGIKQGVEKHSA","length":1106,"molWeight":128072,"crc64":"F8FE624A58482680","md5":"CD0ACA989437ED36E38958B31CF5FD3B"},"extraAttributes":{"countByCommentType":{"CATALYTIC ACTIVITY":4,"PATHWAY":2,"SUBUNIT":1,"SUBCELLULAR LOCATION":1,"SIMILARITY":1,"CAUTION":2},"countByFeatureType":{"Domain":5,"Region":3,"Non-terminal residue":2},"uniParcId":"UPI0017EA1491"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0A7K8KTL1","uniProtkbId":"A0A7K8KTL1_9AVES","entryAudit":{"firstPublicDate":"2021-04-07","lastAnnotationUpdateDate":"2026-11-04","lastSequenceUpdateDate":"2021-04-07","entryVersion":18,"sequenceVersion":1},"annotationScore":5.0,"organism":{"scientificName":"Ardeotis kori","taxonId":89386,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"NXE20437.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000560386"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Archelosauria","Archosauria","Dinosauria","Saurischia","Theropoda","Coelurosauria","Aves","Neognathae","Neoaves","Otidimorphae","Otidiformes","Otididae","Ardeotis"]},"proteinExistence":"3: Inferred from homology","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00039622"}],"value":"Aldehyde dehydrogenase family 3 member A2"},"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00024226"}],"value":"1.2.1.3"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00039117"}],"value":"1.2.1.94"}]},"alternativeNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00042336"}],"value":"Fatty aldehyde dehydrogenase"}}],"flag":"Fragment"},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"NXE20437.1"}],"value":"Aldh3a2"},"orfNames":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"NXE20437.1"}],"value":"ARDKOR_R02999"}]}],"comments":[{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"(2E)-hexadecenal + NAD(+) + H2O = (E)-hexadec-2-enoate + NADH + 2 H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:36135"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:17585"},{"database":"ChEBI","id":"CHEBI:57540"},{"database":"ChEBI","id":"CHEBI:57945"},{"database":"ChEBI","id":"CHEBI:72745"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00048826"}]}},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"(2E,6E)-farnesal + NAD(+) + H2O = (2E,6E)-farnesoate + NADH + 2 H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:24216"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:15894"},{"database":"ChEBI","id":"CHEBI:57540"},{"database":"ChEBI","id":"CHEBI:57945"},{"database":"ChEBI","id":"CHEBI:83276"}],"ecNumber":"1.2.1.94","evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00047920"}]}},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"2,6,10,14-tetramethylpentadecanal + NAD(+) + H2O = 2,6,10,14-tetramethylpentadecanoate + NADH + 2 H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:44016"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:49189"},{"database":"ChEBI","id":"CHEBI:57540"},{"database":"ChEBI","id":"CHEBI:57945"},{"database":"ChEBI","id":"CHEBI:77268"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00047498"}]}},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"22-oxodocosanoate + NAD(+) + H2O = docosanedioate + NADH + 2 H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:39015"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:57540"},{"database":"ChEBI","id":"CHEBI:57945"},{"database":"ChEBI","id":"CHEBI:76298"},{"database":"ChEBI","id":"CHEBI:76299"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00048607"}]}},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"a fatty aldehyde + NAD(+) + H2O = a fatty acid + NADH + 2 H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:49832"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:28868"},{"database":"ChEBI","id":"CHEBI:35746"},{"database":"ChEBI","id":"CHEBI:57540"},{"database":"ChEBI","id":"CHEBI:57945"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00048895"}]}},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"an aldehyde + NAD(+) + H2O = a carboxylate + NADH + 2 H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:16185"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:17478"},{"database":"ChEBI","id":"CHEBI:29067"},{"database":"ChEBI","id":"CHEBI:57540"},{"database":"ChEBI","id":"CHEBI:57945"}],"ecNumber":"1.2.1.3","evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00049194"}]}},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"decanal + NAD(+) + H2O = decanoate + NADH + 2 H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:44104"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:27689"},{"database":"ChEBI","id":"CHEBI:31457"},{"database":"ChEBI","id":"CHEBI:57540"},{"database":"ChEBI","id":"CHEBI:57945"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00048972"}]}},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"dodecanoate + NADH + 2 H(+) = dodecanal + NAD(+) + H2O","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:44168"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:18262"},{"database":"ChEBI","id":"CHEBI:27836"},{"database":"ChEBI","id":"CHEBI:57540"},{"database":"ChEBI","id":"CHEBI:57945"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00048322"}]}},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"heptanal + NAD(+) + H2O = heptanoate + NADH + 2 H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:44108"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:32362"},{"database":"ChEBI","id":"CHEBI:34787"},{"database":"ChEBI","id":"CHEBI:57540"},{"database":"ChEBI","id":"CHEBI:57945"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00047531"}]}},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"hexadecanoate + NADH + 2 H(+) = hexadecanal + NAD(+) + H2O","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:33739"},{"database":"ChEBI","id":"CHEBI:7896"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:17600"},{"database":"ChEBI","id":"CHEBI:57540"},{"database":"ChEBI","id":"CHEBI:57945"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00049148"}]}},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"octadecanal + NAD(+) + H2O = octadecanoate + NADH + 2 H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:44020"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:17034"},{"database":"ChEBI","id":"CHEBI:25629"},{"database":"ChEBI","id":"CHEBI:57540"},{"database":"ChEBI","id":"CHEBI:57945"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00048648"}]}},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"octanal + NAD(+) + H2O = octanoate + NADH + 2 H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:44100"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:17935"},{"database":"ChEBI","id":"CHEBI:25646"},{"database":"ChEBI","id":"CHEBI:57540"},{"database":"ChEBI","id":"CHEBI:57945"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00048806"}]}},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"tetradecanal + NAD(+) + H2O = tetradecanoate + NADH + 2 H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:44172"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:30807"},{"database":"ChEBI","id":"CHEBI:57540"},{"database":"ChEBI","id":"CHEBI:57945"},{"database":"ChEBI","id":"CHEBI:84067"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00047959"}]}},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00011738"}],"value":"Homodimer"}],"commentType":"SUBUNIT"},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004131"}],"value":"Endoplasmic reticulum membrane","id":"SL-0097"},"topology":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004131"}],"value":"Single-pass membrane protein","id":"SL-9904"},"orientation":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004131"}],"value":"Cytoplasmic side","id":"SL-9910"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004524"}],"value":"Microsome membrane","id":"SL-0165"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00009986"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003345"}],"value":"Belongs to the aldehyde dehydrogenase family"}],"commentType":"SIMILARITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"NXE20437.1"}],"value":"The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data"}],"commentType":"CAUTION"}],"features":[{"type":"Transmembrane","location":{"start":{"value":467,"modifier":"EXACT"},"end":{"value":487,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Domain","location":{"start":{"value":3,"modifier":"EXACT"},"end":{"value":425,"modifier":"EXACT"}},"description":"Aldehyde dehydrogenase","evidences":[{"evidenceCode":"ECO:0000259","source":"Pfam","id":"PF00171"}]},{"type":"Coiled coil","location":{"start":{"value":23,"modifier":"EXACT"},"end":{"value":50,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Coils"}]},{"type":"Active site","location":{"start":{"value":210,"modifier":"EXACT"},"end":{"value":210,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR036492-1"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU10007"}]},{"type":"Active site","location":{"start":{"value":244,"modifier":"EXACT"},"end":{"value":244,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR036492-1"}]},{"type":"Active site","location":{"start":{"value":244,"modifier":"EXACT"},"end":{"value":244,"modifier":"EXACT"}},"description":"Nucleophile","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU10008"}]},{"type":"Non-terminal residue","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":1,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"NXE20437.1"}]},{"type":"Non-terminal residue","location":{"start":{"value":488,"modifier":"EXACT"},"end":{"value":488,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"NXE20437.1"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Coils"}],"id":"KW-0175","category":"Domain","name":"Coiled coil"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022824"}],"id":"KW-0256","category":"Cellular component","name":"Endoplasmic reticulum"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022832"}],"id":"KW-0276","category":"Biological process","name":"Fatty acid metabolism"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023098"}],"id":"KW-0443","category":"Biological process","name":"Lipid metabolism"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023136"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022848"}],"id":"KW-0492","category":"Cellular component","name":"Microsome"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023027"}],"id":"KW-0520","category":"Ligand","name":"NAD"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023002"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003345"}],"id":"KW-0560","category":"Molecular function","name":"Oxidoreductase"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022553"}],"id":"KW-0597","category":"PTM","name":"Phosphoprotein"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000560386"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022692"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022989"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-1133","category":"Domain","name":"Transmembrane helix"}],"references":[{"referenceNumber":1,"citation":{"id":"CI-90S2KOISV381S","citationType":"submission","authors":["Zhang G."],"title":"Bird 10,000 Genomes (B10K) Project - Family phase.","publicationDate":"SEP-2019","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"NXE20437.1"}],"value":"B10K-CU-031-01","type":"STRAIN"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"NXE20437.1"}],"value":"Muscle","type":"TISSUE"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"NXE20437.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000560386"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"VWPR01000143","properties":[{"key":"ProteinId","value":"NXE20437.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"AlphaFoldDB","id":"A0A7K8KTL1","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000560386","properties":[{"key":"Component","value":"Unassembled WGS sequence"}]},{"database":"GO","id":"GO:0005789","properties":[{"key":"GoTerm","value":"C:endoplasmic reticulum membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0004028","properties":[{"key":"GoTerm","value":"F:3-chloroallyl aldehyde dehydrogenase activity"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:0120553","properties":[{"key":"GoTerm","value":"F:farnesal dehydrogenase (NAD+) activity"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-EC"}]},{"database":"GO","id":"GO:0006081","properties":[{"key":"GoTerm","value":"P:aldehyde metabolic process"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"CDD","id":"cd07132","properties":[{"key":"EntryName","value":"ALDH_F3AB"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.40.309.10:FF:000003","properties":[{"key":"EntryName","value":"Aldehyde dehydrogenase"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.40.605.10:FF:000004","properties":[{"key":"EntryName","value":"Aldehyde dehydrogenase"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.40.605.10","properties":[{"key":"EntryName","value":"Aldehyde Dehydrogenase, Chain A, domain 1"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.40.309.10","properties":[{"key":"EntryName","value":"Aldehyde Dehydrogenase, Chain A, domain 2"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR016161","properties":[{"key":"EntryName","value":"Ald_DH/histidinol_DH"}]},{"database":"InterPro","id":"IPR016163","properties":[{"key":"EntryName","value":"Ald_DH_C"}]},{"database":"InterPro","id":"IPR016160","properties":[{"key":"EntryName","value":"Ald_DH_CS_CYS"}]},{"database":"InterPro","id":"IPR029510","properties":[{"key":"EntryName","value":"Ald_DH_CS_GLU"}]},{"database":"InterPro","id":"IPR016162","properties":[{"key":"EntryName","value":"Ald_DH_N"}]},{"database":"InterPro","id":"IPR015590","properties":[{"key":"EntryName","value":"Aldehyde_DH_dom"}]},{"database":"InterPro","id":"IPR012394","properties":[{"key":"EntryName","value":"Aldehyde_DH_NAD(P)"}]},{"database":"PANTHER","id":"PTHR43570","properties":[{"key":"EntryName","value":"ALDEHYDE DEHYDROGENASE"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR43570:SF9","properties":[{"key":"EntryName","value":"ALDEHYDE DEHYDROGENASE FAMILY 3 MEMBER A2"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00171","properties":[{"key":"EntryName","value":"Aldedh"},{"key":"MatchStatus","value":"1"}]},{"database":"PIRSF","id":"PIRSF036492","properties":[{"key":"EntryName","value":"ALDH"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF53720","properties":[{"key":"EntryName","value":"ALDH-like"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00070","properties":[{"key":"EntryName","value":"ALDEHYDE_DEHYDR_CYS"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00687","properties":[{"key":"EntryName","value":"ALDEHYDE_DEHYDR_GLU"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MERMQQVVGRARAAFNSGRCRSLEFRMQQLKALERMVQEKEKDILAAIKADLHKCGHNAYSHEILGVLGELALAMDKLPSWAAPQPVKKNLLTMRDEAYICLEPLGVVLIIGAWNYPFVLVMQPLIGAIAAGNAVVVKPSEISENTSRLVADLLPQYLDRELYPVVTGGVPETTELLKQRFDHILYTGSSTVGKIVMAAAAKHLTPVTLELGGKSPCYIDKDCDLAVACRRITWGKYMNCGQTCIAPDYILCDASIQSKVVENIKATLQEFYGEDVKSSPDYERIVNKRHFKRILGLLEGQKIAHGGETDEASCFIAPTILTDVSPDSKVMEEEIFGPVLPILTVKSVDEAIEFINRREKPLALYVFSNDKKLIKRVISETSSGGVTGNDVIMHFFLSTLPFGGVGNSGMGAYHGKHSFETFSHRRACLIKDLKMEGTNKLRYPPGSQKKVDWAKFFLLKRFNKGQIGLVVLALLGLVAAVVIKVSFA","length":488,"molWeight":53917,"crc64":"1AAFF480E9C2CA78","md5":"4370E88DB86C835945B86456B90373D6"},"extraAttributes":{"countByCommentType":{"CATALYTIC ACTIVITY":13,"SUBUNIT":1,"SUBCELLULAR LOCATION":1,"SIMILARITY":1,"CAUTION":1},"countByFeatureType":{"Transmembrane":1,"Domain":1,"Coiled coil":1,"Active site":3,"Non-terminal residue":2},"uniParcId":"UPI001791478A"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0A7K8KUW9","uniProtkbId":"A0A7K8KUW9_9AVES","entryAudit":{"firstPublicDate":"2021-04-07","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2021-04-07","entryVersion":18,"sequenceVersion":1},"annotationScore":5.0,"organism":{"scientificName":"Ardeotis kori","taxonId":89386,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"NXE20877.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000560386"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Archelosauria","Archosauria","Dinosauria","Saurischia","Theropoda","Coelurosauria","Aves","Neognathae","Neoaves","Otidimorphae","Otidiformes","Otididae","Ardeotis"]},"proteinExistence":"3: Inferred from homology","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00040963"}],"value":"11-beta-hydroxysteroid dehydrogenase 1"},"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00038971"}],"value":"1.1.1.146"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00039048"}],"value":"1.1.1.201"}]},"alternativeNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00041676"}],"value":"7-oxosteroid reductase"}},{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00041539"}],"value":"Corticosteroid 11-beta-dehydrogenase isozyme 1"}}],"flag":"Fragment"},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"NXE20877.1"}],"value":"Hsd11b1_1"},"orfNames":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"NXE20877.1"}],"value":"ARDKOR_R01521"}]}],"comments":[{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"11beta,17beta-dihydroxyandrost-4-ene-3-one + NADP(+) = 17beta-hydroxyandrost-4-ene-3,11-dione + NADPH + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:86451"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:34133"},{"database":"ChEBI","id":"CHEBI:57783"},{"database":"ChEBI","id":"CHEBI:58349"},{"database":"ChEBI","id":"CHEBI:81481"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00095462"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:86452"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00095462"}]},{"directionType":"right-to-left","reactionCrossReference":{"database":"Rhea","id":"RHEA:86453"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00095462"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"11beta-hydroxyandrost-4-ene-3,17-dione + NADP(+) = androst-4-ene-3,11,17-trione + NADPH + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:86411"},{"database":"ChEBI","id":"CHEBI:2495"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:27967"},{"database":"ChEBI","id":"CHEBI:57783"},{"database":"ChEBI","id":"CHEBI:58349"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00095599"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:86412"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00095599"}]},{"directionType":"right-to-left","reactionCrossReference":{"database":"Rhea","id":"RHEA:86413"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00095599"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"3beta,7alpha-dihydroxyandrost-5-en-17-one + NADP(+) = 3beta-hydroxy-5-androstene-7,17-dione + NADPH + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:69440"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:57783"},{"database":"ChEBI","id":"CHEBI:58349"},{"database":"ChEBI","id":"CHEBI:81471"},{"database":"ChEBI","id":"CHEBI:183808"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00048678"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:69441"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00048678"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"3beta-hydroxy-5-androstene-7,17-dione + NADPH + H(+) = 3beta,7beta-dihydroxyandrost-5-en-17-one + NADP(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:69452"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:57783"},{"database":"ChEBI","id":"CHEBI:58349"},{"database":"ChEBI","id":"CHEBI:183368"},{"database":"ChEBI","id":"CHEBI:183808"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00047608"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:69453"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00047608"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"3beta-hydroxy-5alpha-androstane-7,17-dione + NADPH + H(+) = 3beta,7beta-dihydroxy-5alpha-androstan-17-one + NADP(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:69456"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:57783"},{"database":"ChEBI","id":"CHEBI:58349"},{"database":"ChEBI","id":"CHEBI:79834"},{"database":"ChEBI","id":"CHEBI:183809"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00047373"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:69457"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00047373"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"7-oxocholesterol + NADPH + H(+) = 7beta-hydroxycholesterol + NADP(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:68656"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:42989"},{"database":"ChEBI","id":"CHEBI:57783"},{"database":"ChEBI","id":"CHEBI:58349"},{"database":"ChEBI","id":"CHEBI:64294"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00048585"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:68657"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00048585"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"7-oxolithocholate + NADPH + H(+) = ursodeoxycholate + NADP(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:47540"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:57783"},{"database":"ChEBI","id":"CHEBI:58349"},{"database":"ChEBI","id":"CHEBI:78604"},{"database":"ChEBI","id":"CHEBI:78605"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00049462"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:47541"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00049462"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"7-oxopregnenolone + NADPH + H(+) = 7beta-hydroxypregnenolone + NADP(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:69436"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:57783"},{"database":"ChEBI","id":"CHEBI:58349"},{"database":"ChEBI","id":"CHEBI:183806"},{"database":"ChEBI","id":"CHEBI:183807"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00049520"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:69437"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00049520"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"a 7beta-hydroxysteroid + NADP(+) = a 7-oxosteroid + NADPH + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:20233"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:35349"},{"database":"ChEBI","id":"CHEBI:47789"},{"database":"ChEBI","id":"CHEBI:57783"},{"database":"ChEBI","id":"CHEBI:58349"}],"ecNumber":"1.1.1.201","evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00049300"}]},"physiologicalReactions":[{"directionType":"right-to-left","reactionCrossReference":{"database":"Rhea","id":"RHEA:20235"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00049300"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"an 11beta-hydroxysteroid + NADP(+) = an 11-oxosteroid + NADPH + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:11388"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:35346"},{"database":"ChEBI","id":"CHEBI:47787"},{"database":"ChEBI","id":"CHEBI:57783"},{"database":"ChEBI","id":"CHEBI:58349"}],"ecNumber":"1.1.1.146","evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00048376"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:11389"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00048376"}]},{"directionType":"right-to-left","reactionCrossReference":{"database":"Rhea","id":"RHEA:11390"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00048376"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"chenodeoxycholate + NADP(+) = 7-oxolithocholate + NADPH + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:53820"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:36234"},{"database":"ChEBI","id":"CHEBI:57783"},{"database":"ChEBI","id":"CHEBI:58349"},{"database":"ChEBI","id":"CHEBI:78605"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00047269"}]},"physiologicalReactions":[{"directionType":"right-to-left","reactionCrossReference":{"database":"Rhea","id":"RHEA:53822"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00047269"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"corticosterone + NADP(+) = 11-dehydrocorticosterone + NADPH + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:42200"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:16827"},{"database":"ChEBI","id":"CHEBI:57783"},{"database":"ChEBI","id":"CHEBI:58349"},{"database":"ChEBI","id":"CHEBI:78600"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00047749"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:42201"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00047749"}]},{"directionType":"right-to-left","reactionCrossReference":{"database":"Rhea","id":"RHEA:42202"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00047749"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"glycochenodeoxycholate + NADP(+) = 7-oxoglycolithocholate + NADPH + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:65056"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:36252"},{"database":"ChEBI","id":"CHEBI:57783"},{"database":"ChEBI","id":"CHEBI:58349"},{"database":"ChEBI","id":"CHEBI:137818"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00048661"}]},"physiologicalReactions":[{"directionType":"right-to-left","reactionCrossReference":{"database":"Rhea","id":"RHEA:65058"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00048661"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"glycoursodeoxycholate + NADP(+) = 7-oxoglycolithocholate + NADPH + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:68976"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:57783"},{"database":"ChEBI","id":"CHEBI:58349"},{"database":"ChEBI","id":"CHEBI:132030"},{"database":"ChEBI","id":"CHEBI:137818"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00048060"}]},"physiologicalReactions":[{"directionType":"right-to-left","reactionCrossReference":{"database":"Rhea","id":"RHEA:68978"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00048060"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"taurochenodeoxycholate + NADP(+) = 7-oxotaurolithocholate + NADPH + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:65060"},{"database":"ChEBI","id":"CHEBI:9407"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:57783"},{"database":"ChEBI","id":"CHEBI:58349"},{"database":"ChEBI","id":"CHEBI:137724"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00048061"}]},"physiologicalReactions":[{"directionType":"right-to-left","reactionCrossReference":{"database":"Rhea","id":"RHEA:65062"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00048061"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"tauroursodeoxycholate + NADP(+) = 7-oxotaurolithocholate + NADPH + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:68980"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:57783"},{"database":"ChEBI","id":"CHEBI:58349"},{"database":"ChEBI","id":"CHEBI:132028"},{"database":"ChEBI","id":"CHEBI:137724"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00048702"}]},"physiologicalReactions":[{"directionType":"right-to-left","reactionCrossReference":{"database":"Rhea","id":"RHEA:68982"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00048702"}]}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00011738"}],"value":"Homodimer"}],"commentType":"SUBUNIT"},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004648"}],"value":"Endoplasmic reticulum membrane","id":"SL-0097"},"topology":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004648"}],"value":"Single-pass type II membrane protein","id":"SL-9906"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00006484"}],"value":"Belongs to the short-chain dehydrogenases/reductases (SDR) family"}],"commentType":"SIMILARITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"NXE20877.1"}],"value":"The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data"}],"commentType":"CAUTION"}],"features":[{"type":"Active site","location":{"start":{"value":183,"modifier":"EXACT"},"end":{"value":183,"modifier":"EXACT"}},"description":"Proton acceptor","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU10001"}]},{"type":"Non-terminal residue","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":1,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"NXE20877.1"}]},{"type":"Non-terminal residue","location":{"start":{"value":293,"modifier":"EXACT"},"end":{"value":293,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"NXE20877.1"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022824"}],"id":"KW-0256","category":"Cellular component","name":"Endoplasmic reticulum"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023136"}],"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023002"}],"id":"KW-0560","category":"Molecular function","name":"Oxidoreductase"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000560386"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022692"}],"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022989"}],"id":"KW-1133","category":"Domain","name":"Transmembrane helix"}],"references":[{"referenceNumber":1,"citation":{"id":"CI-90S2KOISV381S","citationType":"submission","authors":["Zhang G."],"title":"Bird 10,000 Genomes (B10K) Project - Family phase.","publicationDate":"SEP-2019","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"NXE20877.1"}],"value":"B10K-CU-031-01","type":"STRAIN"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"NXE20877.1"}],"value":"Muscle","type":"TISSUE"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"NXE20877.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000560386"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"VWPR01000181","properties":[{"key":"ProteinId","value":"NXE20877.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"AlphaFoldDB","id":"A0A7K8KUW9","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000560386","properties":[{"key":"Component","value":"Unassembled WGS sequence"}]},{"database":"GO","id":"GO:0005789","properties":[{"key":"GoTerm","value":"C:endoplasmic reticulum membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0070524","properties":[{"key":"GoTerm","value":"F:11-beta-hydroxysteroid dehydrogenase (NADP+) activity"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-EC"}]},{"database":"GO","id":"GO:0047022","properties":[{"key":"GoTerm","value":"F:7-beta-hydroxysteroid dehydrogenase (NADP+) activity"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-EC"}]},{"database":"GO","id":"GO:0005496","properties":[{"key":"GoTerm","value":"F:steroid binding"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:0006706","properties":[{"key":"GoTerm","value":"P:steroid catabolic process"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"CDD","id":"cd05332","properties":[{"key":"EntryName","value":"11beta-HSD1_like_SDR_c"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.40.50.720:FF:000329","properties":[{"key":"EntryName","value":"Corticosteroid 11-beta-dehydrogenase isozyme 1"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.40.50.720","properties":[{"key":"EntryName","value":"NAD(P)-binding Rossmann-like Domain"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR051253","properties":[{"key":"EntryName","value":"11-beta-HSD"}]},{"database":"InterPro","id":"IPR036291","properties":[{"key":"EntryName","value":"NAD(P)-bd_dom_sf"}]},{"database":"InterPro","id":"IPR020904","properties":[{"key":"EntryName","value":"Sc_DH/Rdtase_CS"}]},{"database":"InterPro","id":"IPR002347","properties":[{"key":"EntryName","value":"SDR_fam"}]},{"database":"PANTHER","id":"PTHR44279:SF1","properties":[{"key":"EntryName","value":"11-BETA-HYDROXYSTEROID DEHYDROGENASE 1"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR44279","properties":[{"key":"EntryName","value":"HYDROXYSTEROID (11-BETA) DEHYDROGENASE 1-LIKE B-RELATED"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00106","properties":[{"key":"EntryName","value":"adh_short"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR00081","properties":[{"key":"EntryName","value":"GDHRDH"}]},{"database":"SUPFAM","id":"SSF51735","properties":[{"key":"EntryName","value":"NAD(P)-binding Rossmann-fold domains"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00061","properties":[{"key":"EntryName","value":"ADH_SHORT"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MGRLQKILIPFLGLVLAFWFYSARENFKPEMLKGKRVLVTGASTGIGEQMAYHLARMGSHIVITARTEAKLQKVVERCLELGAASARYVSGTMEDMAFAEHVVKEAETSLGGLDMLILNHVGTSYFNYFNGDVEHVRKLLEINFLSYVAMTVSALPMLKKSEGSIVVVSSMAGKVGFPFTVPYSATKFALDGFFSSLRQEFTIQRVNVSITLCILSFIDTEHAVRAAADRLLVSPAPREECALEILKGAALRRRELYYRYGATRLPLLLRDWAAELLDYLVRSRYRLDGLGGS","length":293,"molWeight":32647,"crc64":"6706690BF7254379","md5":"298E259595E9B227F95927BAFEFABB4A"},"extraAttributes":{"countByCommentType":{"CATALYTIC ACTIVITY":16,"SUBUNIT":1,"SUBCELLULAR LOCATION":1,"SIMILARITY":1,"CAUTION":1},"countByFeatureType":{"Active site":1,"Non-terminal residue":2},"uniParcId":"UPI001825F279"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0A7K8KV71","uniProtkbId":"A0A7K8KV71_9AVES","entryAudit":{"firstPublicDate":"2021-04-07","lastAnnotationUpdateDate":"2026-11-04","lastSequenceUpdateDate":"2021-04-07","entryVersion":22,"sequenceVersion":1},"annotationScore":5.0,"organism":{"scientificName":"Ardeotis kori","taxonId":89386,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"NXE20939.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000560386"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Archelosauria","Archosauria","Dinosauria","Saurischia","Theropoda","Coelurosauria","Aves","Neognathae","Neoaves","Otidimorphae","Otidiformes","Otididae","Ardeotis"]},"proteinExistence":"3: Inferred from homology","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00034536"}],"value":"Flavin-containing monooxygenase 1"},"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00034528"}],"value":"1.14.13.148"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00012850"}],"value":"1.14.13.8"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00012698"}],"value":"1.6.3.1"}]},"alternativeNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00034561"}],"value":"Dimethylaniline monooxygenase [N-oxide-forming] 1"}},{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00033301"}],"value":"Dimethylaniline monooxygenase [N-oxide-forming] 5"}},{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00029725"}],"value":"Dimethylaniline oxidase 1"}},{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00029728"}],"value":"Dimethylaniline oxidase 5"}},{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00019213"}],"value":"Flavin-containing monooxygenase 5"}},{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00033213"}],"value":"NADPH oxidase"}},{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00034554"}],"value":"Trimethylamine monooxygenase"}}],"flag":"Fragment"},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"NXE20939.1"}],"value":"Fmo5_0"},"orfNames":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"NXE20939.1"}],"value":"ARDKOR_R03041"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00045722"}],"value":"Acts as a Baeyer-Villiger monooxygenase on a broad range of substrates. Catalyzes the insertion of an oxygen atom into a carbon-carbon bond adjacent to a carbonyl, which converts ketones to esters. Active on diverse carbonyl compounds, whereas soft nucleophiles are mostly non- or poorly reactive. In contrast with other forms of FMO it is non- or poorly active on 'classical' substrates such as drugs, pesticides, and dietary components containing soft nucleophilic heteroatoms. Able to oxidize drug molecules bearing a carbonyl group on an aliphatic chain, such as nabumetone and pentoxifylline. Also, in the absence of substrates, shows slow but yet significant NADPH oxidase activity. Acts as a positive modulator of cholesterol biosynthesis as well as glucose homeostasis, promoting metabolic aging via pleiotropic effects"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00045957"}],"value":"Broad spectrum monooxygenase that catalyzes the oxygenation of a wide variety of nitrogen- and sulfur-containing compounds including xenobiotics. Catalyzes the S-oxygenation of hypotaurine to produce taurine, an organic osmolyte involved in cell volume regulation as well as a variety of cytoprotective and developmental processes. In vitro, catalyzes the N-oxygenation of trimethylamine (TMA) to produce trimethylamine N-oxide (TMAO) and could therefore participate to the detoxification of this compound that is generated by the action of gut microbiota from dietary precursors such as choline, choline containing compounds, betaine or L-carnitine"}],"commentType":"FUNCTION"},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"(2E)-geranial + NADPH + O2 + H(+) = (1E)-2,6-dimethylhepta-1,5-dien-1-yl formate + NADP(+) + H2O","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:54860"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:15379"},{"database":"ChEBI","id":"CHEBI:16980"},{"database":"ChEBI","id":"CHEBI:57783"},{"database":"ChEBI","id":"CHEBI:58349"},{"database":"ChEBI","id":"CHEBI:138375"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00048989"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:54861"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00048989"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"N,N-dimethylaniline + NADPH + O2 + H(+) = N,N-dimethylaniline N-oxide + NADP(+) + H2O","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:24468"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:15379"},{"database":"ChEBI","id":"CHEBI:16269"},{"database":"ChEBI","id":"CHEBI:17735"},{"database":"ChEBI","id":"CHEBI:57783"},{"database":"ChEBI","id":"CHEBI:58349"}],"ecNumber":"1.14.13.8","evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00049443"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:24469"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00049443"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"NADPH + O2 + H(+) = H2O2 + NADP(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:11260"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:15379"},{"database":"ChEBI","id":"CHEBI:16240"},{"database":"ChEBI","id":"CHEBI:57783"},{"database":"ChEBI","id":"CHEBI:58349"}],"ecNumber":"1.6.3.1","evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00047864"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:11261"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00047864"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"heptan-2-one + NADPH + O2 + H(+) = pentyl acetate + NADP(+) + H2O","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:54836"},{"database":"ChEBI","id":"CHEBI:5672"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:15379"},{"database":"ChEBI","id":"CHEBI:57783"},{"database":"ChEBI","id":"CHEBI:58349"},{"database":"ChEBI","id":"CHEBI:87362"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00047574"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:54837"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00047574"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"heptan-4-one + NADPH + O2 + H(+) = propyl butanoate + NADP(+) + H2O","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:54852"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:15379"},{"database":"ChEBI","id":"CHEBI:57783"},{"database":"ChEBI","id":"CHEBI:58349"},{"database":"ChEBI","id":"CHEBI:89484"},{"database":"ChEBI","id":"CHEBI:89719"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00048990"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:54853"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00048990"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"hexan-3-one + NADPH + O2 + H(+) = ethyl butanoate + NADP(+) + H2O","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:54844"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:15379"},{"database":"ChEBI","id":"CHEBI:57783"},{"database":"ChEBI","id":"CHEBI:58349"},{"database":"ChEBI","id":"CHEBI:88764"},{"database":"ChEBI","id":"CHEBI:89891"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00047977"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:54845"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00047977"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"hexan-3-one + NADPH + O2 + H(+) = propyl propanoate + NADP(+) + H2O","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:54848"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:15379"},{"database":"ChEBI","id":"CHEBI:57783"},{"database":"ChEBI","id":"CHEBI:58349"},{"database":"ChEBI","id":"CHEBI:89828"},{"database":"ChEBI","id":"CHEBI:89891"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00047426"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:54849"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00047426"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"hypotaurine + NADH + O2 + H(+) = taurine + NAD(+) + H2O","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:74111"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:15379"},{"database":"ChEBI","id":"CHEBI:57540"},{"database":"ChEBI","id":"CHEBI:57853"},{"database":"ChEBI","id":"CHEBI:57945"},{"database":"ChEBI","id":"CHEBI:507393"}],"ecNumber":"1.14.13.8","evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00047338"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:74112"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00047338"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"hypotaurine + NADPH + O2 + H(+) = taurine + NADP(+) + H2O","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:69819"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:15379"},{"database":"ChEBI","id":"CHEBI:57783"},{"database":"ChEBI","id":"CHEBI:57853"},{"database":"ChEBI","id":"CHEBI:58349"},{"database":"ChEBI","id":"CHEBI:507393"}],"ecNumber":"1.14.13.8","evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00048041"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:69820"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00048041"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"octan-3-one + NADPH + O2 + H(+) = ethyl hexanoate + NADP(+) + H2O","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:54856"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:15379"},{"database":"ChEBI","id":"CHEBI:57783"},{"database":"ChEBI","id":"CHEBI:58349"},{"database":"ChEBI","id":"CHEBI:80946"},{"database":"ChEBI","id":"CHEBI:86055"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00048459"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:54857"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00048459"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"octan-3-one + NADPH + O2 + H(+) = pentyl propanoate + NADP(+) + H2O","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:54840"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:15379"},{"database":"ChEBI","id":"CHEBI:57783"},{"database":"ChEBI","id":"CHEBI:58349"},{"database":"ChEBI","id":"CHEBI:80946"},{"database":"ChEBI","id":"CHEBI:87373"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00049475"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:54841"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00049475"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"sulcatone + NADPH + O2 + H(+) = 4-methylpent-3-en-1-yl acetate + NADP(+) + H2O","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:54864"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:15379"},{"database":"ChEBI","id":"CHEBI:16310"},{"database":"ChEBI","id":"CHEBI:57783"},{"database":"ChEBI","id":"CHEBI:58349"},{"database":"ChEBI","id":"CHEBI:138373"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00047855"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:54865"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00047855"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"trimethylamine + NADPH + O2 = trimethylamine N-oxide + NADP(+) + H2O","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:31979"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:15379"},{"database":"ChEBI","id":"CHEBI:15724"},{"database":"ChEBI","id":"CHEBI:57783"},{"database":"ChEBI","id":"CHEBI:58349"},{"database":"ChEBI","id":"CHEBI:58389"}],"ecNumber":"1.14.13.148","evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00048088"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:31980"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00048088"}]}]},{"commentType":"COFACTOR","cofactors":[{"name":"FAD","evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00001974"}],"cofactorCrossReference":{"database":"ChEBI","id":"CHEBI:57692"}}]},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004389"}],"value":"Endoplasmic reticulum membrane","id":"SL-0097"},"topology":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004389"}],"value":"Single-pass membrane protein","id":"SL-9904"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004524"}],"value":"Microsome membrane","id":"SL-0165"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00009183"}],"value":"Belongs to the FMO family"}],"commentType":"SIMILARITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"NXE20939.1"}],"value":"The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data"}],"commentType":"CAUTION"}],"features":[{"type":"Non-terminal residue","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":1,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"NXE20939.1"}]},{"type":"Non-terminal residue","location":{"start":{"value":334,"modifier":"EXACT"},"end":{"value":334,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"NXE20939.1"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022824"}],"id":"KW-0256","category":"Cellular component","name":"Endoplasmic reticulum"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022827"}],"id":"KW-0274","category":"Ligand","name":"FAD"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022630"}],"id":"KW-0285","category":"Ligand","name":"Flavoprotein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023098"}],"id":"KW-0443","category":"Biological process","name":"Lipid metabolism"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023136"}],"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022481"}],"id":"KW-0488","category":"PTM","name":"Methylation"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022848"}],"id":"KW-0492","category":"Cellular component","name":"Microsome"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023033"},{"evidenceCode":"ECO:0000313","source":"EMBL","id":"NXE20939.1"}],"id":"KW-0503","category":"Molecular function","name":"Monooxygenase"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022857"}],"id":"KW-0521","category":"Ligand","name":"NADP"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023002"}],"id":"KW-0560","category":"Molecular function","name":"Oxidoreductase"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022553"}],"id":"KW-0597","category":"PTM","name":"Phosphoprotein"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000560386"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022692"}],"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022989"}],"id":"KW-1133","category":"Domain","name":"Transmembrane helix"}],"references":[{"referenceNumber":1,"citation":{"id":"CI-90S2KOISV381S","citationType":"submission","authors":["Zhang G."],"title":"Bird 10,000 Genomes (B10K) Project - Family phase.","publicationDate":"SEP-2019","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"NXE20939.1"}],"value":"B10K-CU-031-01","type":"STRAIN"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"NXE20939.1"}],"value":"Muscle","type":"TISSUE"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"NXE20939.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000560386"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"VWPR01000185","properties":[{"key":"ProteinId","value":"NXE20939.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"AlphaFoldDB","id":"A0A7K8KV71","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000560386","properties":[{"key":"Component","value":"Unassembled WGS sequence"}]},{"database":"GO","id":"GO:0005789","properties":[{"key":"GoTerm","value":"C:endoplasmic reticulum membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0050660","properties":[{"key":"GoTerm","value":"F:flavin adenine dinucleotide binding"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0004499","properties":[{"key":"GoTerm","value":"F:N,N-dimethylaniline monooxygenase activity"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0016174","properties":[{"key":"GoTerm","value":"F:NAD(P)H oxidase H2O2-forming activity"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-EC"}]},{"database":"GO","id":"GO:0050661","properties":[{"key":"GoTerm","value":"F:NADP binding"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0034899","properties":[{"key":"GoTerm","value":"F:trimethylamine monooxygenase activity"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-EC"}]},{"database":"FunFam","id":"3.50.50.60:FF:000159","properties":[{"key":"EntryName","value":"Dimethylaniline monooxygenase [N-oxide-forming]"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.50.50.60","properties":[{"key":"EntryName","value":"FAD/NAD(P)-binding domain"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR036188","properties":[{"key":"EntryName","value":"FAD/NAD-bd_sf"}]},{"database":"InterPro","id":"IPR000960","properties":[{"key":"EntryName","value":"Flavin_mOase"}]},{"database":"InterPro","id":"IPR020946","properties":[{"key":"EntryName","value":"Flavin_mOase-like"}]},{"database":"InterPro","id":"IPR002257","properties":[{"key":"EntryName","value":"Flavin_mOase_5"}]},{"database":"InterPro","id":"IPR050346","properties":[{"key":"EntryName","value":"FMO-like"}]},{"database":"PANTHER","id":"PTHR23023","properties":[{"key":"EntryName","value":"DIMETHYLANILINE MONOOXYGENASE"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00743","properties":[{"key":"EntryName","value":"FMO-like"},{"key":"MatchStatus","value":"1"}]},{"database":"PIRSF","id":"PIRSF000332","properties":[{"key":"EntryName","value":"FMO"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR00370","properties":[{"key":"EntryName","value":"FMOXYGENASE"}]},{"database":"PRINTS","id":"PR01125","properties":[{"key":"EntryName","value":"FMOXYGENASE5"}]},{"database":"SUPFAM","id":"SSF51905","properties":[{"key":"EntryName","value":"FAD/NAD(P)-binding domain"},{"key":"MatchStatus","value":"2"}]}],"sequence":{"value":"MAARRVAIIGAGASGLCALKCCLDEGLVPTCFERSRDIGGLWRFEEHPEEGRASIYPSVIINTSKEMMCFSDFPIPEDFPNYMHNSKIMEYFRMYARRFDLLRHIRFRTSVCRVAKRPDFAATGQWEVVTESEGKQEAAVFDAVLVCTGHHTKAHLPLSTFPGLEKFEGWYLHSRDYKSPQSFSGKRVIVVGTGNSGIDIAVELSHVAKQVFLSTKRGTWVLHRVADSGYPFDLSYISRFIQLLQNLLPHNTSSFLLERKLNARFNHALYGLQPQHRVLHQHPTINDDLPNRIISGRVRVKPNVQEFTETSAIFEDGTREDIDVVVFATGYSFS","length":334,"molWeight":37917,"crc64":"38728DA2B899E51B","md5":"60BE783DB68AAA177247C75C1F1563C1"},"extraAttributes":{"countByCommentType":{"FUNCTION":2,"CATALYTIC ACTIVITY":13,"COFACTOR":1,"SUBCELLULAR LOCATION":1,"SIMILARITY":1,"CAUTION":1},"countByFeatureType":{"Non-terminal residue":2},"uniParcId":"UPI0018170852"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0A7K8KXA6","uniProtkbId":"A0A7K8KXA6_9AVES","entryAudit":{"firstPublicDate":"2021-04-07","lastAnnotationUpdateDate":"2026-11-04","lastSequenceUpdateDate":"2021-04-07","entryVersion":20,"sequenceVersion":1},"annotationScore":5.0,"organism":{"scientificName":"Ardeotis kori","taxonId":89386,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"NXE21580.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000560386"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Archelosauria","Archosauria","Dinosauria","Saurischia","Theropoda","Coelurosauria","Aves","Neognathae","Neoaves","Otidimorphae","Otidiformes","Otididae","Ardeotis"]},"proteinExistence":"3: Inferred from homology","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00074091"}],"value":"Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial"},"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00067027"}],"value":"2.6.1.39"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00066546"}],"value":"2.6.1.4"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00013010"}],"value":"2.6.1.63"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00012751"}],"value":"2.6.1.7"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00067059"}],"value":"2.6.1.73"}]},"alternativeNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00083735"}],"value":"2-aminoadipate aminotransferase"}},{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00080916"}],"value":"2-aminoadipate transaminase"}},{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00082705"}],"value":"Alpha-aminoadipate aminotransferase"}},{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00082040"}],"value":"Glycine transaminase AADAT"}},{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00083286"}],"value":"Kynurenine aminotransferase II"}},{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00081438"}],"value":"Kynurenine--glyoxylate transaminase AADAT"}},{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00082796"}],"value":"Kynurenine--oxoglutarate aminotransferase II"}},{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00083236"}],"value":"Kynurenine--oxoglutarate transaminase 2"}},{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00080697"}],"value":"Kynurenine--oxoglutarate transaminase II"}},{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00075068"}],"value":"Methionine--glyoxylate transaminase AADAT"}}],"flag":"Fragment"},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"NXE21580.1"}],"value":"Aadat"},"orfNames":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"NXE21580.1"}],"value":"ARDKOR_R13754"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00056991"}],"value":"Transaminase with broad substrate specificity. Has transaminase activity towards aminoadipate, kynurenine, methionine and glutamate. Shows activity also towards tryptophan, aspartate and hydroxykynurenine. Accepts a variety of oxo-acids as amino-group acceptors, with a preference for 2-oxoglutarate, 2-oxocaproic acid, phenylpyruvate and alpha-oxo-gamma-methiol butyric acid. Can also use glyoxylate as amino-group acceptor (in vitro)"}],"commentType":"FUNCTION"},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"2-oxo-3-sulfanylpropanoate + L-kynurenine = kynurenate + L-cysteine + H2O","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:69104"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:35235"},{"database":"ChEBI","id":"CHEBI:57678"},{"database":"ChEBI","id":"CHEBI:57959"},{"database":"ChEBI","id":"CHEBI:58454"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00051742"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:69105"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00051742"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"2-oxoadipate + L-kynurenine = L-2-aminoadipate + kynurenate + H2O","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:70047"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:57499"},{"database":"ChEBI","id":"CHEBI:57959"},{"database":"ChEBI","id":"CHEBI:58454"},{"database":"ChEBI","id":"CHEBI:58672"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00051759"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:70048"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00051759"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"2-oxobutanoate + L-kynurenine = (2S)-2-aminobutanoate + kynurenate + H2O","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:66044"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:16763"},{"database":"ChEBI","id":"CHEBI:57959"},{"database":"ChEBI","id":"CHEBI:58454"},{"database":"ChEBI","id":"CHEBI:74359"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00051879"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:66045"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00051879"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"2-oxohexanoate + L-kynurenine = L-2-aminohexanoate + kynurenate + H2O","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:66060"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:35177"},{"database":"ChEBI","id":"CHEBI:57959"},{"database":"ChEBI","id":"CHEBI:58454"},{"database":"ChEBI","id":"CHEBI:58455"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00052128"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:66061"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00052128"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"2-oxopentanoate + L-kynurenine = L-2-aminopentanoate + kynurenate + H2O","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:66076"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:28644"},{"database":"ChEBI","id":"CHEBI:57959"},{"database":"ChEBI","id":"CHEBI:58441"},{"database":"ChEBI","id":"CHEBI:58454"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00051090"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:66077"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00051090"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"3-phenylpyruvate + L-kynurenine = kynurenate + L-phenylalanine + H2O","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:66092"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:18005"},{"database":"ChEBI","id":"CHEBI:57959"},{"database":"ChEBI","id":"CHEBI:58095"},{"database":"ChEBI","id":"CHEBI:58454"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00052580"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:66093"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00052580"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"4-methyl-2-oxopentanoate + L-kynurenine = kynurenate + L-leucine + H2O","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:66068"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:17865"},{"database":"ChEBI","id":"CHEBI:57427"},{"database":"ChEBI","id":"CHEBI:57959"},{"database":"ChEBI","id":"CHEBI:58454"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00052831"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:66069"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00052831"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"4-methylsulfanyl-2-oxobutanoate + L-kynurenine = kynurenate + L-methionine + H2O","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:69096"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:16723"},{"database":"ChEBI","id":"CHEBI:57844"},{"database":"ChEBI","id":"CHEBI:57959"},{"database":"ChEBI","id":"CHEBI:58454"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00051184"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:69097"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00051184"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"L-2-aminoadipate + glyoxylate = 2-oxoadipate + glycine","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:69112"},{"database":"ChEBI","id":"CHEBI:36655"},{"database":"ChEBI","id":"CHEBI:57305"},{"database":"ChEBI","id":"CHEBI:57499"},{"database":"ChEBI","id":"CHEBI:58672"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00050937"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:69113"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00050937"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"L-kynurenine + 2-oxoglutarate = kynurenate + L-glutamate + H2O","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:65560"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:16810"},{"database":"ChEBI","id":"CHEBI:29985"},{"database":"ChEBI","id":"CHEBI:57959"},{"database":"ChEBI","id":"CHEBI:58454"}],"ecNumber":"2.6.1.7","evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00047478"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:65561"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00047478"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"L-kynurenine + glyoxylate = kynurenate + glycine + H2O","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:65896"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:36655"},{"database":"ChEBI","id":"CHEBI:57305"},{"database":"ChEBI","id":"CHEBI:57959"},{"database":"ChEBI","id":"CHEBI:58454"}],"ecNumber":"2.6.1.63","evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00047677"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:65897"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00047677"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"L-leucine + glyoxylate = 4-methyl-2-oxopentanoate + glycine","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:69128"},{"database":"ChEBI","id":"CHEBI:17865"},{"database":"ChEBI","id":"CHEBI:36655"},{"database":"ChEBI","id":"CHEBI:57305"},{"database":"ChEBI","id":"CHEBI:57427"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00052518"}]}},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"L-tryptophan + glyoxylate = indole-3-pyruvate + glycine","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:69124"},{"database":"ChEBI","id":"CHEBI:17640"},{"database":"ChEBI","id":"CHEBI:36655"},{"database":"ChEBI","id":"CHEBI:57305"},{"database":"ChEBI","id":"CHEBI:57912"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00052393"}]}},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"L-tyrosine + glyoxylate = 3-(4-hydroxyphenyl)pyruvate + glycine","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:69116"},{"database":"ChEBI","id":"CHEBI:36242"},{"database":"ChEBI","id":"CHEBI:36655"},{"database":"ChEBI","id":"CHEBI:57305"},{"database":"ChEBI","id":"CHEBI:58315"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00050142"}]}},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"glycine + 2-oxoglutarate = glyoxylate + L-glutamate","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:14089"},{"database":"ChEBI","id":"CHEBI:16810"},{"database":"ChEBI","id":"CHEBI:29985"},{"database":"ChEBI","id":"CHEBI:36655"},{"database":"ChEBI","id":"CHEBI:57305"}],"ecNumber":"2.6.1.4","evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00052537"}]}},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"glyoxylate + L-methionine = 4-methylsulfanyl-2-oxobutanoate + glycine","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:22884"},{"database":"ChEBI","id":"CHEBI:16723"},{"database":"ChEBI","id":"CHEBI:36655"},{"database":"ChEBI","id":"CHEBI:57305"},{"database":"ChEBI","id":"CHEBI:57844"}],"ecNumber":"2.6.1.73","evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00052404"}]}},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"glyoxylate + L-phenylalanine = 3-phenylpyruvate + glycine","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:69120"},{"database":"ChEBI","id":"CHEBI:18005"},{"database":"ChEBI","id":"CHEBI:36655"},{"database":"ChEBI","id":"CHEBI:57305"},{"database":"ChEBI","id":"CHEBI:58095"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00052400"}]}},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"indole-3-pyruvate + L-kynurenine = kynurenate + L-tryptophan + H2O","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:66052"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:17640"},{"database":"ChEBI","id":"CHEBI:57912"},{"database":"ChEBI","id":"CHEBI:57959"},{"database":"ChEBI","id":"CHEBI:58454"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00052124"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:66053"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00052124"}]}]},{"commentType":"COFACTOR","cofactors":[{"name":"pyridoxal 5'-phosphate","evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00001933"}],"cofactorCrossReference":{"database":"ChEBI","id":"CHEBI:597326"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00060610"}],"value":"Amino-acid degradation; L-lysine degradation via saccharopine pathway; glutaryl-CoA from L-lysine: step 4/6"}],"commentType":"PATHWAY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00007441"}],"value":"Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family"}],"commentType":"SIMILARITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"NXE21580.1"}],"value":"The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data"}],"commentType":"CAUTION"}],"features":[{"type":"Domain","location":{"start":{"value":65,"modifier":"EXACT"},"end":{"value":410,"modifier":"EXACT"}},"description":"Aminotransferase class I/classII large","evidences":[{"evidenceCode":"ECO:0000259","source":"Pfam","id":"PF00155"}]},{"type":"Non-terminal residue","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":1,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"NXE21580.1"}]},{"type":"Non-terminal residue","location":{"start":{"value":412,"modifier":"EXACT"},"end":{"value":412,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"NXE21580.1"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022576"}],"id":"KW-0032","category":"Molecular function","name":"Aminotransferase"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022898"}],"id":"KW-0663","category":"Ligand","name":"Pyridoxal phosphate"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000560386"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022679"}],"id":"KW-0808","category":"Molecular function","name":"Transferase"}],"references":[{"referenceNumber":1,"citation":{"id":"CI-90S2KOISV381S","citationType":"submission","authors":["Zhang G."],"title":"Bird 10,000 Genomes (B10K) Project - Family phase.","publicationDate":"SEP-2019","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"NXE21580.1"}],"value":"B10K-CU-031-01","type":"STRAIN"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"NXE21580.1"}],"value":"Muscle","type":"TISSUE"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"NXE21580.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000560386"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"VWPR01000245","properties":[{"key":"ProteinId","value":"NXE21580.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"AlphaFoldDB","id":"A0A7K8KXA6","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000560386","properties":[{"key":"Component","value":"Unassembled WGS sequence"}]},{"database":"GO","id":"GO:0005759","properties":[{"key":"GoTerm","value":"C:mitochondrial matrix"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0047958","properties":[{"key":"GoTerm","value":"F:glycine:2-oxoglutarate transaminase activity"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-EC"}]},{"database":"GO","id":"GO:0047536","properties":[{"key":"GoTerm","value":"F:L-2-aminoadipate:2-oxoglutarate transaminase activity"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-EC"}]},{"database":"GO","id":"GO:0016212","properties":[{"key":"GoTerm","value":"F:L-kynurenine:2-oxoglutarate transaminase activity"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-EC"}]},{"database":"GO","id":"GO:0047315","properties":[{"key":"GoTerm","value":"F:L-kynurenine:glyoxylate transaminase activity"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-EC"}]},{"database":"GO","id":"GO:0050094","properties":[{"key":"GoTerm","value":"F:L-methionine:glyoxylate transaminase activity"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-EC"}]},{"database":"GO","id":"GO:0030170","properties":[{"key":"GoTerm","value":"F:pyridoxal phosphate binding"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"CDD","id":"cd00609","properties":[{"key":"EntryName","value":"AAT_like"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.40.640.10:FF:000071","properties":[{"key":"EntryName","value":"Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.90.1150.10","properties":[{"key":"EntryName","value":"Aspartate Aminotransferase, domain 1"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.40.640.10","properties":[{"key":"EntryName","value":"Type I PLP-dependent aspartate aminotransferase-like (Major domain)"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR004839","properties":[{"key":"EntryName","value":"Aminotransferase_I/II_large"}]},{"database":"InterPro","id":"IPR050859","properties":[{"key":"EntryName","value":"Class-I_PLP-dep_aminotransf"}]},{"database":"InterPro","id":"IPR015424","properties":[{"key":"EntryName","value":"PyrdxlP-dep_Trfase"}]},{"database":"InterPro","id":"IPR015421","properties":[{"key":"EntryName","value":"PyrdxlP-dep_Trfase_major"}]},{"database":"InterPro","id":"IPR015422","properties":[{"key":"EntryName","value":"PyrdxlP-dep_Trfase_small"}]},{"database":"PANTHER","id":"PTHR42790","properties":[{"key":"EntryName","value":"AMINOTRANSFERASE"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR42790:SF19","properties":[{"key":"EntryName","value":"KYNURENINE_ALPHA-AMINOADIPATE AMINOTRANSFERASE, MITOCHONDRIAL"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00155","properties":[{"key":"EntryName","value":"Aminotran_1_2"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF53383","properties":[{"key":"EntryName","value":"PLP-dependent transferases"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MNYSRFITSVSAARKASPIRLLTELMQKSPPSLISLAGGAPNPNLFPFKRATVAIEHGPAVEIGEDLMKRALQYSASAGIPELLSWLKDFQRNLHNPPTANYSPEQGQMEVCVTTGSQEGLCKVFEMLINPGDNILLDAPTYSGTLAALRPLGCNIINVPSDQHGIISKALKEILSTWSSEDVKNRNHHLPKFLYTIPNGCNPTGNSLTTERKKEIYELARKYDFLIIEDDPYYFLQFKKPWAPTFLSMDVDGRVIRTDSFSKILSSGLRIGFLTGPKPLIDRVILHIQVSTMHTSTFTQIMISQLLQQWGEKGFLEHVDRVVDFYRTQRDAMLIAADKWLKDSAEWYPPAAGMFLWIKIKGISDTQQLIMEKALQKEVLLVPGGAFNINSSEPSSYVRASFSLSSPAQMDL","length":412,"molWeight":46069,"crc64":"D9CCCB34C4763122","md5":"F2202E3942C54811346C0FF3C5CB4AC8"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"CATALYTIC ACTIVITY":18,"COFACTOR":1,"PATHWAY":1,"SIMILARITY":1,"CAUTION":1},"countByFeatureType":{"Domain":1,"Non-terminal residue":2},"uniParcId":"UPI001801CA6C"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0A7K8KXX7","uniProtkbId":"A0A7K8KXX7_9AVES","entryAudit":{"firstPublicDate":"2021-04-07","lastAnnotationUpdateDate":"2026-11-04","lastSequenceUpdateDate":"2021-04-07","entryVersion":26,"sequenceVersion":1},"annotationScore":5.0,"organism":{"scientificName":"Ardeotis kori","taxonId":89386,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"NXE21282.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000560386"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Archelosauria","Archosauria","Dinosauria","Saurischia","Theropoda","Coelurosauria","Aves","Neognathae","Neoaves","Otidimorphae","Otidiformes","Otididae","Ardeotis"]},"proteinExistence":"3: Inferred from homology","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00014021"}],"value":"Rho-associated protein kinase 2"},"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00094901"}],"value":"2.7.11.39"}]},"alternativeNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00031784"}],"value":"Rho-associated, coiled-coil-containing protein kinase 2"}},{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00032261"}],"value":"Rho-associated, coiled-coil-containing protein kinase II"}},{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00030038"}],"value":"p164 ROCK-2"}}],"flag":"Fragment"},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"NXE21282.1"}],"value":"Rock2"},"orfNames":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"NXE21282.1"}],"value":"ARDKOR_R03871"}]}],"comments":[{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:17989"},{"database":"Rhea","id":"RHEA-COMP:9863"},{"database":"Rhea","id":"RHEA-COMP:11604"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:29999"},{"database":"ChEBI","id":"CHEBI:30616"},{"database":"ChEBI","id":"CHEBI:83421"},{"database":"ChEBI","id":"CHEBI:456216"}],"ecNumber":"2.7.11.1","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU10027"}]}},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:17989"},{"database":"Rhea","id":"RHEA-COMP:9863"},{"database":"Rhea","id":"RHEA-COMP:11604"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:29999"},{"database":"ChEBI","id":"CHEBI:30616"},{"database":"ChEBI","id":"CHEBI:83421"},{"database":"ChEBI","id":"CHEBI:456216"}],"ecNumber":"2.7.11.39","evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00093860"}]}},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:46608"},{"database":"Rhea","id":"RHEA-COMP:11060"},{"database":"Rhea","id":"RHEA-COMP:11605"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:30013"},{"database":"ChEBI","id":"CHEBI:30616"},{"database":"ChEBI","id":"CHEBI:61977"},{"database":"ChEBI","id":"CHEBI:456216"}],"ecNumber":"2.7.11.1","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU10027"}]}},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:46608"},{"database":"Rhea","id":"RHEA-COMP:11060"},{"database":"Rhea","id":"RHEA-COMP:11605"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:30013"},{"database":"ChEBI","id":"CHEBI:30616"},{"database":"ChEBI","id":"CHEBI:61977"},{"database":"ChEBI","id":"CHEBI:456216"}],"ecNumber":"2.7.11.39","evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00093924"}]}},{"commentType":"COFACTOR","cofactors":[{"name":"Mg(2+)","evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00001946"}],"cofactorCrossReference":{"database":"ChEBI","id":"CHEBI:18420"}}]},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004202"}],"value":"Cell membrane","id":"SL-0039"},"topology":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004202"}],"value":"Peripheral membrane protein","id":"SL-9903"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004300"}],"value":"Cytoplasm, cytoskeleton, microtubule organizing center, centrosome","id":"SL-0048"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004123"}],"value":"Nucleus","id":"SL-0191"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00009903"}],"value":"Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family"}],"commentType":"SIMILARITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00159"}],"value":"Belongs to the protein kinase superfamily. Ser/Thr protein kinase family"}],"commentType":"SIMILARITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00618"}],"value":"Lacks conserved residue(s) required for the propagation of feature annotation"}],"commentType":"CAUTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"NXE21282.1"}],"value":"The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data"}],"commentType":"CAUTION"}],"features":[{"type":"Domain","location":{"start":{"value":45,"modifier":"EXACT"},"end":{"value":307,"modifier":"EXACT"}},"description":"Protein kinase","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50011"}]},{"type":"Domain","location":{"start":{"value":310,"modifier":"EXACT"},"end":{"value":378,"modifier":"EXACT"}},"description":"AGC-kinase C-terminal","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS51285"}]},{"type":"Domain","location":{"start":{"value":447,"modifier":"EXACT"},"end":{"value":523,"modifier":"EXACT"}},"description":"REM-1","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS51860"}]},{"type":"Domain","location":{"start":{"value":932,"modifier":"EXACT"},"end":{"value":1000,"modifier":"EXACT"}},"description":"RhoBD","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS51859"}]},{"type":"Domain","location":{"start":{"value":1162,"modifier":"EXACT"},"end":{"value":1361,"modifier":"EXACT"}},"description":"PH","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50003"}]},{"type":"Domain","location":{"start":{"value":1272,"modifier":"EXACT"},"end":{"value":1327,"modifier":"EXACT"}},"description":"Phorbol-ester/DAG-type","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50081"}]},{"type":"Zinc finger","location":{"start":{"value":1272,"modifier":"EXACT"},"end":{"value":1327,"modifier":"EXACT"}},"description":"Phorbol-ester/DAG-type","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00226"}]},{"type":"Region","location":{"start":{"value":1127,"modifier":"EXACT"},"end":{"value":1158,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":1357,"modifier":"EXACT"},"end":{"value":1399,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Coiled coil","location":{"start":{"value":385,"modifier":"EXACT"},"end":{"value":568,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Coils"}]},{"type":"Coiled coil","location":{"start":{"value":594,"modifier":"EXACT"},"end":{"value":972,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Coils"}]},{"type":"Coiled coil","location":{"start":{"value":1009,"modifier":"EXACT"},"end":{"value":1054,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Coils"}]},{"type":"Compositional bias","location":{"start":{"value":1374,"modifier":"EXACT"},"end":{"value":1388,"modifier":"EXACT"}},"description":"Polar residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Active site","location":{"start":{"value":167,"modifier":"EXACT"},"end":{"value":167,"modifier":"EXACT"}},"description":"Proton acceptor","evidences":[{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR037568-1"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU10027"}]},{"type":"Binding site","location":{"start":{"value":74,"modifier":"EXACT"},"end":{"value":74,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:30616"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR037568-2"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU10141"}],"ligand":{"name":"ATP","id":"ChEBI:CHEBI:30616"}},{"type":"Modified residue","location":{"start":{"value":349,"modifier":"EXACT"},"end":{"value":349,"modifier":"EXACT"}},"description":"Phosphothreonine","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00618"}]},{"type":"Modified residue","location":{"start":{"value":367,"modifier":"EXACT"},"end":{"value":367,"modifier":"EXACT"}},"description":"Phosphothreonine","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00618"}]},{"type":"Modified residue","location":{"start":{"value":368,"modifier":"EXACT"},"end":{"value":368,"modifier":"EXACT"}},"description":"Phosphotyrosine","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00618"}]},{"type":"Non-terminal residue","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":1,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"NXE21282.1"}]},{"type":"Non-terminal residue","location":{"start":{"value":1399,"modifier":"EXACT"},"end":{"value":1399,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"NXE21282.1"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022840"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU10141"}],"id":"KW-0067","category":"Ligand","name":"ATP-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023108"}],"id":"KW-0090","category":"Biological process","name":"Biological rhythms"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022475"}],"id":"KW-1003","category":"Cellular component","name":"Cell membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023054"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU01207"}],"id":"KW-0175","category":"Domain","name":"Coiled coil"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022490"}],"id":"KW-0963","category":"Cellular component","name":"Cytoplasm"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023212"}],"id":"KW-0206","category":"Cellular component","name":"Cytoskeleton"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022777"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00159"}],"id":"KW-0418","category":"Molecular function","name":"Kinase"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022842"}],"id":"KW-0460","category":"Ligand","name":"Magnesium"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023136"}],"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022723"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00226"}],"id":"KW-0479","category":"Ligand","name":"Metal-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022741"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU10141"}],"id":"KW-0547","category":"Ligand","name":"Nucleotide-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023242"}],"id":"KW-0539","category":"Cellular component","name":"Nucleus"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022553"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00618"}],"id":"KW-0597","category":"PTM","name":"Phosphoprotein"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000560386"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022527"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00159"}],"id":"KW-0723","category":"Molecular function","name":"Serine/threonine-protein kinase"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022679"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00159"}],"id":"KW-0808","category":"Molecular function","name":"Transferase"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022833"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00226"}],"id":"KW-0862","category":"Ligand","name":"Zinc"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022771"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00226"}],"id":"KW-0863","category":"Domain","name":"Zinc-finger"}],"references":[{"referenceNumber":1,"citation":{"id":"CI-90S2KOISV381S","citationType":"submission","authors":["Zhang G."],"title":"Bird 10,000 Genomes (B10K) Project - Family phase.","publicationDate":"SEP-2019","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"NXE21282.1"}],"value":"B10K-CU-031-01","type":"STRAIN"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"NXE21282.1"}],"value":"Muscle","type":"TISSUE"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"NXE21282.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000560386"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"VWPR01000216","properties":[{"key":"ProteinId","value":"NXE21282.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"Proteomes","id":"UP000560386","properties":[{"key":"Component","value":"Unassembled WGS sequence"}]},{"database":"GO","id":"GO:0005813","properties":[{"key":"GoTerm","value":"C:centrosome"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:0005737","properties":[{"key":"GoTerm","value":"C:cytoplasm"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:0005634","properties":[{"key":"GoTerm","value":"C:nucleus"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0005886","properties":[{"key":"GoTerm","value":"C:plasma membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0005524","properties":[{"key":"GoTerm","value":"F:ATP binding"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniRule"}]},{"database":"GO","id":"GO:0019992","properties":[{"key":"GoTerm","value":"F:diacylglycerol binding"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniRule"}]},{"database":"GO","id":"GO:0072518","properties":[{"key":"GoTerm","value":"F:Rho-dependent protein serine/threonine kinase activity"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:0031267","properties":[{"key":"GoTerm","value":"F:small GTPase binding"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0031032","properties":[{"key":"GoTerm","value":"P:actomyosin structure organization"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:0030866","properties":[{"key":"GoTerm","value":"P:cortical actin cytoskeleton organization"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:0048598","properties":[{"key":"GoTerm","value":"P:embryonic morphogenesis"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:0000281","properties":[{"key":"GoTerm","value":"P:mitotic cytokinesis"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:0010825","properties":[{"key":"GoTerm","value":"P:positive regulation of centrosome duplication"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0032956","properties":[{"key":"GoTerm","value":"P:regulation of actin cytoskeleton organization"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:1901888","properties":[{"key":"GoTerm","value":"P:regulation of cell junction assembly"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:0007266","properties":[{"key":"GoTerm","value":"P:Rho protein signal transduction"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniRule"}]},{"database":"GO","id":"GO:0006939","properties":[{"key":"GoTerm","value":"P:smooth muscle contraction"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"CDD","id":"cd20875","properties":[{"key":"EntryName","value":"C1_ROCK2"},{"key":"MatchStatus","value":"1"}]},{"database":"CDD","id":"cd11638","properties":[{"key":"EntryName","value":"HR1_ROCK2"},{"key":"MatchStatus","value":"1"}]},{"database":"CDD","id":"cd01242","properties":[{"key":"EntryName","value":"PH_ROCK"},{"key":"MatchStatus","value":"1"}]},{"database":"CDD","id":"cd22250","properties":[{"key":"EntryName","value":"ROCK_SBD"},{"key":"MatchStatus","value":"1"}]},{"database":"CDD","id":"cd05596","properties":[{"key":"EntryName","value":"STKc_ROCK"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.10.510.10:FF:000047","properties":[{"key":"EntryName","value":"Rho-associated protein kinase 1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.30.60.20:FF:000036","properties":[{"key":"EntryName","value":"Rho-associated protein kinase 1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.5.340:FF:000016","properties":[{"key":"EntryName","value":"Rho-associated protein kinase 2"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.5.730:FF:000001","properties":[{"key":"EntryName","value":"rho-associated protein kinase 2"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.30.29.30:FF:000033","properties":[{"key":"EntryName","value":"Rho-associated protein kinase 2"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.30.200.20:FF:000072","properties":[{"key":"EntryName","value":"Rho-associated protein kinase 2"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.20.5.340","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.30.60.20","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.30.200.20","properties":[{"key":"EntryName","value":"Phosphorylase Kinase, domain 1"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.30.29.30","properties":[{"key":"EntryName","value":"Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.20.5.730","properties":[{"key":"EntryName","value":"Single helix bin"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.10.510.10","properties":[{"key":"EntryName","value":"Transferase(Phosphotransferase) domain 1"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR000961","properties":[{"key":"EntryName","value":"AGC-kinase_C"}]},{"database":"InterPro","id":"IPR046349","properties":[{"key":"EntryName","value":"C1-like_sf"}]},{"database":"InterPro","id":"IPR011072","properties":[{"key":"EntryName","value":"HR1_rho-bd"}]},{"database":"InterPro","id":"IPR011009","properties":[{"key":"EntryName","value":"Kinase-like_dom_sf"}]},{"database":"InterPro","id":"IPR057529","properties":[{"key":"EntryName","value":"MRCK/ROCK_PH"}]},{"database":"InterPro","id":"IPR011993","properties":[{"key":"EntryName","value":"PH-like_dom_sf"}]},{"database":"InterPro","id":"IPR001849","properties":[{"key":"EntryName","value":"PH_domain"}]},{"database":"InterPro","id":"IPR002219","properties":[{"key":"EntryName","value":"PKC_DAG/PE"}]},{"database":"InterPro","id":"IPR000719","properties":[{"key":"EntryName","value":"Prot_kinase_dom"}]},{"database":"InterPro","id":"IPR017441","properties":[{"key":"EntryName","value":"Protein_kinase_ATP_BS"}]},{"database":"InterPro","id":"IPR050839","properties":[{"key":"EntryName","value":"Rho-assoc_Ser/Thr_Kinase"}]},{"database":"InterPro","id":"IPR020684","properties":[{"key":"EntryName","value":"ROCK1/ROCK2"}]},{"database":"InterPro","id":"IPR037311","properties":[{"key":"EntryName","value":"ROCK2_HR1"}]},{"database":"InterPro","id":"IPR015008","properties":[{"key":"EntryName","value":"ROCK_Rho-bd_dom"}]},{"database":"InterPro","id":"IPR064701","properties":[{"key":"EntryName","value":"ROCK_SBR"}]},{"database":"InterPro","id":"IPR008271","properties":[{"key":"EntryName","value":"Ser/Thr_kinase_AS"}]},{"database":"PANTHER","id":"PTHR22988","properties":[{"key":"EntryName","value":"MYOTONIC DYSTROPHY S/T KINASE-RELATED"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR22988:SF28","properties":[{"key":"EntryName","value":"RHO-ASSOCIATED PROTEIN KINASE 2"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF25346","properties":[{"key":"EntryName","value":"PH_MRCK"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00069","properties":[{"key":"EntryName","value":"Pkinase"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF08912","properties":[{"key":"EntryName","value":"Rho_Binding"},{"key":"MatchStatus","value":"1"}]},{"database":"PIRSF","id":"PIRSF037568","properties":[{"key":"EntryName","value":"Rho_kinase"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00109","properties":[{"key":"EntryName","value":"C1"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00233","properties":[{"key":"EntryName","value":"PH"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00133","properties":[{"key":"EntryName","value":"S_TK_X"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00220","properties":[{"key":"EntryName","value":"S_TKc"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF57889","properties":[{"key":"EntryName","value":"Cysteine-rich domain"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF103652","properties":[{"key":"EntryName","value":"G protein-binding domain"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF90257","properties":[{"key":"EntryName","value":"Myosin rod fragments"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF50729","properties":[{"key":"EntryName","value":"PH domain-like"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF56112","properties":[{"key":"EntryName","value":"Protein kinase-like (PK-like)"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS51285","properties":[{"key":"EntryName","value":"AGC_KINASE_CTER"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50003","properties":[{"key":"EntryName","value":"PH_DOMAIN"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00107","properties":[{"key":"EntryName","value":"PROTEIN_KINASE_ATP"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50011","properties":[{"key":"EntryName","value":"PROTEIN_KINASE_DOM"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00108","properties":[{"key":"EntryName","value":"PROTEIN_KINASE_ST"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS51860","properties":[{"key":"EntryName","value":"REM_1"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS51859","properties":[{"key":"EntryName","value":"RHO_BD"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50081","properties":[{"key":"EntryName","value":"ZF_DAG_PE_2"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"DGLNSLVLDLDYPALRKNKNIDNFLNRYEKIVEKIRALQMKAEDYDVVKVIGRGAFGEVQLVRHKLTQKVYAMKLLSKFEMIKRSDSAFFWEERDIMAFANSPWVVQLFCAFQDDKYLYMVMEYMPGGDLVNLMSNYDVPEKWAKFYTAEVVLALDAIHSMGLIHRDVKPDNMLLDKYGHLKLADFGTCMKMDETGMVRCDTAVGTPDYISPEVLKSQGGDGYYGRECDWWSVGVFLFEMLVGDTPFYADSLVGTYSKIMDHKNSLHFPDDVEISKHAKNLICAFLTDRDVRLGRNGVEEIKHHPFFKSDQWNWDNIRETAAPVVPELSSDIDSSNFDDIEDDKGDVETFPIPKAFVGNQLPFIGFTYYRENLLLSDSSQSCRENESVQSSKNEFQKKLSKLEEQLSNELQAKDELEQKYRSTNTRLEKIAKELDEEITSRKNVESAVRQLEREKALLQHKNTEYQRKAEHEADKKRNLENEVNSLKDQLEDLKKRNQNSQISNEKINQLQRQACQLYISNSSLRSESDTAARLRKNQTESTKQIQQLEANNRELQDKNCLLENAKLKLEKDFLNLQSALESERRDRSHGSEIISDLQGRISSLEEEVKNGKSALAKLEMEKRQLQEKLTDLEKEKSNMEIDMTYKFKVMQQNLEQEEAEHKATKARLADKNKIYESIEEAKSEAMKEMEKKLLEERALKQKVENRLLEAEKQRSMLDCDLKQSQQKINELLRQKDILNEDVKNLTLKIEQETQKRCLTQNDLKMQTQQVNTLKMSEKQLKQENNHLQEIKLSLEKQNNELRKERQDADGQMKELQDQLEAEQYFSTLYKTQVRELKEECEEKTKLCKEMQQKIQELQDERDSLAAQLEITLTKADSEQLARSIAEEQYSDLEKEKIMKELEIKEMMARHKQELTEKDATIASLEEANRTLTSDVANLANEKEELNNKLKEVQEQITKLKEEEANIGNIKAQFEKQLLNERTLKTQAVNKLAEIMNRKGPVKRGADTDVRRKEKENRKLHMELKSEREKLTQMMIKYQKEINEMQAQIAEESQIRIELQMTLDSKDSDIEQLRSQLQSLHIGLDNSSIGSGPGDAEADDGFPVHITQSHTMESMSFTYQHSSTSVSIATKPSSSRMLLDSDSDSEEEPLSCSHSPTEVDSTESRLEGWLSLPVRNNTKKFGWVKKYVIVSSKKILFYDSEQDKEQSNPYMVLDIDKLFHVRPVTQTDVYRADSKEIPRIFQILYANEGESKKEQEFPVEPMGEKSNYICHKGHEFIPTLYHFPTNCEACMKPLWHMFKPPPALECRRCHIKCHKDHMDKKEEIIAPCKVYYDISTAKNLLLLANSTEEQQKWVSRLVKKIPKKPPAPDPFARSSPRTSMKVQPNQSIRRPSRQLPPNKP","length":1399,"molWeight":162438,"crc64":"07071EF649C326FF","md5":"1C3AECE21F70785E70A421B202358955"},"extraAttributes":{"countByCommentType":{"CATALYTIC ACTIVITY":4,"COFACTOR":1,"SUBCELLULAR LOCATION":1,"SIMILARITY":2,"CAUTION":2},"countByFeatureType":{"Domain":6,"Zinc finger":1,"Region":2,"Coiled coil":3,"Compositional bias":1,"Active site":1,"Binding site":1,"Modified residue":3,"Non-terminal residue":2},"uniParcId":"UPI0017D9D5A3"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0A7K8KYW4","uniProtkbId":"A0A7K8KYW4_9AVES","entryAudit":{"firstPublicDate":"2021-04-07","lastAnnotationUpdateDate":"2026-11-04","lastSequenceUpdateDate":"2021-04-07","entryVersion":23,"sequenceVersion":1},"annotationScore":5.0,"organism":{"scientificName":"Ardeotis kori","taxonId":89386,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"NXE22268.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000560386"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Archelosauria","Archosauria","Dinosauria","Saurischia","Theropoda","Coelurosauria","Aves","Neognathae","Neoaves","Otidimorphae","Otidiformes","Otididae","Ardeotis"]},"proteinExistence":"3: Inferred from homology","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00034338"}],"value":"Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN"},"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00013081"}],"value":"3.1.3.16"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00013064"}],"value":"3.1.3.48"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00013015"}],"value":"3.1.3.67"}]},"alternativeNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00044309"}],"value":"Inositol polyphosphate 3-phosphatase"}},{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00034370"}],"value":"Phosphatase and tensin homolog"}}],"flag":"Fragment"},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"NXE22268.1"}],"value":"Pten"},"orfNames":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"NXE22268.1"}],"value":"ARDKOR_R09276"}]}],"comments":[{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + H2O = 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + phosphate","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:43560"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:43474"},{"database":"ChEBI","id":"CHEBI:83420"},{"database":"ChEBI","id":"CHEBI:83423"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00034256"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:43561"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00034256"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + H2O = 1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + phosphate","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:43552"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:43474"},{"database":"ChEBI","id":"CHEBI:83416"},{"database":"ChEBI","id":"CHEBI:83419"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00034268"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:43553"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00034268"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"1D-myo-inositol 1,3,4,5,6-pentakisphosphate + H2O = 1D-myo-inositol 1,4,5,6-tetrakisphosphate + phosphate","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:77143"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:43474"},{"database":"ChEBI","id":"CHEBI:57627"},{"database":"ChEBI","id":"CHEBI:57733"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00043762"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:77144"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00043762"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"1D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O = 1D-myo-inositol 1,4,5-trisphosphate + phosphate","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:77155"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:43474"},{"database":"ChEBI","id":"CHEBI:57895"},{"database":"ChEBI","id":"CHEBI:203600"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00043734"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:77156"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00043734"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:20629"},{"database":"Rhea","id":"RHEA-COMP:9863"},{"database":"Rhea","id":"RHEA-COMP:11604"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:29999"},{"database":"ChEBI","id":"CHEBI:43474"},{"database":"ChEBI","id":"CHEBI:83421"}],"ecNumber":"3.1.3.16","evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00047986"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:20630"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00047986"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:47004"},{"database":"Rhea","id":"RHEA-COMP:11060"},{"database":"Rhea","id":"RHEA-COMP:11605"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:30013"},{"database":"ChEBI","id":"CHEBI:43474"},{"database":"ChEBI","id":"CHEBI:61977"}],"ecNumber":"3.1.3.16","evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00048832"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:47005"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00048832"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:10684"},{"database":"Rhea","id":"RHEA-COMP:10136"},{"database":"Rhea","id":"RHEA-COMP:20101"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:43474"},{"database":"ChEBI","id":"CHEBI:46858"},{"database":"ChEBI","id":"CHEBI:61978"}],"ecNumber":"3.1.3.48","evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00051341"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:10685"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00051341"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + phosphate","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:25017"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:43474"},{"database":"ChEBI","id":"CHEBI:57836"},{"database":"ChEBI","id":"CHEBI:58456"}],"ecNumber":"3.1.3.67","evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00043760"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:25018"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00043760"}]}]},{"commentType":"COFACTOR","cofactors":[{"name":"Mg(2+)","evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00001946"}],"cofactorCrossReference":{"database":"ChEBI","id":"CHEBI:18420"}}]},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004552"}],"value":"Cell projection, dendritic spine","id":"SL-0284"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004496"}],"value":"Cytoplasm","id":"SL-0086"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004322"}],"value":"Nucleus, PML body","id":"SL-0465"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00034105"}],"value":"Postsynaptic density","id":"SL-0297"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00007881"}],"value":"Belongs to the PTEN phosphatase protein family"}],"commentType":"SIMILARITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"NXE22268.1"}],"value":"The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data"}],"commentType":"CAUTION"}],"features":[{"type":"Domain","location":{"start":{"value":14,"modifier":"EXACT"},"end":{"value":185,"modifier":"EXACT"}},"description":"Phosphatase tensin-type","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS51181"}]},{"type":"Domain","location":{"start":{"value":102,"modifier":"EXACT"},"end":{"value":173,"modifier":"EXACT"}},"description":"Tyrosine specific protein phosphatases","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50056"}]},{"type":"Domain","location":{"start":{"value":190,"modifier":"EXACT"},"end":{"value":350,"modifier":"EXACT"}},"description":"C2 tensin-type","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS51182"}]},{"type":"Region","location":{"start":{"value":353,"modifier":"EXACT"},"end":{"value":403,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":360,"modifier":"EXACT"},"end":{"value":369,"modifier":"EXACT"}},"description":"Low complexity","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":383,"modifier":"EXACT"},"end":{"value":393,"modifier":"EXACT"}},"description":"Acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Active site","location":{"start":{"value":124,"modifier":"EXACT"},"end":{"value":124,"modifier":"EXACT"}},"description":"Phosphocysteine intermediate","evidences":[{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR038025-50"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00590"}]},{"type":"Non-terminal residue","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":1,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"NXE22268.1"}]},{"type":"Non-terminal residue","location":{"start":{"value":403,"modifier":"EXACT"},"end":{"value":403,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"NXE22268.1"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022703"}],"id":"KW-0053","category":"Biological process","name":"Apoptosis"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023273"}],"id":"KW-0966","category":"Cellular component","name":"Cell projection"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022490"}],"id":"KW-0963","category":"Cellular component","name":"Cytoplasm"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022801"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00590"}],"id":"KW-0378","category":"Molecular function","name":"Hydrolase"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023098"}],"id":"KW-0443","category":"Biological process","name":"Lipid metabolism"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022902"}],"id":"KW-0524","category":"Biological process","name":"Neurogenesis"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023242"}],"id":"KW-0539","category":"Cellular component","name":"Nucleus"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022912"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00590"}],"id":"KW-0904","category":"Molecular function","name":"Protein phosphatase"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000560386"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023018"}],"id":"KW-0770","category":"Cellular component","name":"Synapse"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022843"}],"id":"KW-0832","category":"PTM","name":"Ubl conjugation"}],"references":[{"referenceNumber":1,"citation":{"id":"CI-90S2KOISV381S","citationType":"submission","authors":["Zhang G."],"title":"Bird 10,000 Genomes (B10K) Project - Family phase.","publicationDate":"SEP-2019","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"NXE22268.1"}],"value":"B10K-CU-031-01","type":"STRAIN"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"NXE22268.1"}],"value":"Muscle","type":"TISSUE"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"NXE22268.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000560386"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"VWPR01000321","properties":[{"key":"ProteinId","value":"NXE22268.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"AlphaFoldDB","id":"A0A7K8KYW4","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000560386","properties":[{"key":"Component","value":"Unassembled WGS sequence"}]},{"database":"GO","id":"GO:0005829","properties":[{"key":"GoTerm","value":"C:cytosol"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:0043197","properties":[{"key":"GoTerm","value":"C:dendritic spine"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0005886","properties":[{"key":"GoTerm","value":"C:plasma membrane"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:0016605","properties":[{"key":"GoTerm","value":"C:PML body"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0014069","properties":[{"key":"GoTerm","value":"C:postsynaptic density"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0019899","properties":[{"key":"GoTerm","value":"F:enzyme binding"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0051717","properties":[{"key":"GoTerm","value":"F:inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0016314","properties":[{"key":"GoTerm","value":"F:phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-EC"}]},{"database":"GO","id":"GO:0051800","properties":[{"key":"GoTerm","value":"F:phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0004722","properties":[{"key":"GoTerm","value":"F:protein serine/threonine phosphatase activity"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-EC"}]},{"database":"GO","id":"GO:0004725","properties":[{"key":"GoTerm","value":"F:protein tyrosine phosphatase activity"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-EC"}]},{"database":"GO","id":"GO:0048870","properties":[{"key":"GoTerm","value":"P:cell motility"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:0010648","properties":[{"key":"GoTerm","value":"P:negative regulation of cell communication"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0008285","properties":[{"key":"GoTerm","value":"P:negative regulation of cell population proliferation"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0051129","properties":[{"key":"GoTerm","value":"P:negative regulation of cellular component organization"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0051093","properties":[{"key":"GoTerm","value":"P:negative regulation of developmental process"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0051241","properties":[{"key":"GoTerm","value":"P:negative regulation of multicellular organismal process"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0023057","properties":[{"key":"GoTerm","value":"P:negative regulation of signaling"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0043491","properties":[{"key":"GoTerm","value":"P:phosphatidylinositol 3-kinase/protein kinase B signal transduction"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:0046856","properties":[{"key":"GoTerm","value":"P:phosphatidylinositol dephosphorylation"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0051726","properties":[{"key":"GoTerm","value":"P:regulation of cell cycle"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0045595","properties":[{"key":"GoTerm","value":"P:regulation of cell differentiation"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0051896","properties":[{"key":"GoTerm","value":"P:regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"CDD","id":"cd14509","properties":[{"key":"EntryName","value":"PTP_PTEN"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.60.40.1110:FF:000003","properties":[{"key":"EntryName","value":"Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.90.190.10:FF:000029","properties":[{"key":"EntryName","value":"Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.60.40.1110","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.90.190.10","properties":[{"key":"EntryName","value":"Protein tyrosine phosphatase superfamily"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR017361","properties":[{"key":"EntryName","value":"Bifunc_PIno_P3_Pase/Pase_PTEN"}]},{"database":"InterPro","id":"IPR035892","properties":[{"key":"EntryName","value":"C2_domain_sf"}]},{"database":"InterPro","id":"IPR051281","properties":[{"key":"EntryName","value":"Dual-spec_lipid-protein_phosph"}]},{"database":"InterPro","id":"IPR029021","properties":[{"key":"EntryName","value":"Prot-tyrosine_phosphatase-like"}]},{"database":"InterPro","id":"IPR045101","properties":[{"key":"EntryName","value":"PTP_PTEN"}]},{"database":"InterPro","id":"IPR014020","properties":[{"key":"EntryName","value":"Tensin_C2-dom"}]},{"database":"InterPro","id":"IPR029023","properties":[{"key":"EntryName","value":"Tensin_phosphatase"}]},{"database":"InterPro","id":"IPR016130","properties":[{"key":"EntryName","value":"Tyr_Pase_AS"}]},{"database":"InterPro","id":"IPR003595","properties":[{"key":"EntryName","value":"Tyr_Pase_cat"}]},{"database":"InterPro","id":"IPR000387","properties":[{"key":"EntryName","value":"Tyr_Pase_dom"}]},{"database":"PANTHER","id":"PTHR12305","properties":[{"key":"EntryName","value":"PHOSPHATASE WITH HOMOLOGY TO TENSIN"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR12305:SF81","properties":[{"key":"EntryName","value":"PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF10409","properties":[{"key":"EntryName","value":"PTEN_C2"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF22785","properties":[{"key":"EntryName","value":"Tc-R-P"},{"key":"MatchStatus","value":"1"}]},{"database":"PIRSF","id":"PIRSF038025","properties":[{"key":"EntryName","value":"PTEN"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM01326","properties":[{"key":"EntryName","value":"PTEN_C2"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00404","properties":[{"key":"EntryName","value":"PTPc_motif"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM01301","properties":[{"key":"EntryName","value":"PTPlike_phytase"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF52799","properties":[{"key":"EntryName","value":"(Phosphotyrosine protein) phosphatases II"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF49562","properties":[{"key":"EntryName","value":"C2 domain (Calcium/lipid-binding domain, CaLB)"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS51182","properties":[{"key":"EntryName","value":"C2_TENSIN"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS51181","properties":[{"key":"EntryName","value":"PPASE_TENSIN"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00383","properties":[{"key":"EntryName","value":"TYR_PHOSPHATASE_1"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50056","properties":[{"key":"EntryName","value":"TYR_PHOSPHATASE_2"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MTAIIKEIVSRNKRRYQEDGFDLDLTYIYPNIIAMGFPAERLEGVYRNNIDDVVRFLDSKHKNHYKIYNLCAERHYDTAKFNCRVAQYPFEDHNPPQLELIKPFCEDLDQWLSEDDNHVAAIHCKAGKGRTGVMICAYLLHRGKFLKAQEALDFYGEVRTRDKKGVTIPSQRRYVYYYSYLLKNHLDYRPVALLFHKMMFETIPMFSSGTCNPQFVVYQLKVKIFTSPSGPSRREDKYMYFEFPQPLPVCGDIKVEFFHKQNKMLKKDKMFHFWVNTFFIGLDENSDKVENGSLVADQELDGIFSTERSDNDKEYLILTLTKNDLDKANKDKANRYFSPNFKVKLFFTKTVEEPSNPEASSSTSVTPDVSDNEPDHYRYSDTTDSDPENEPFDEDQHTQITKV","length":403,"molWeight":47226,"crc64":"AE9190B4CE913E72","md5":"DE12ADBD4CAE5B3BD1CE96CDE528B289"},"extraAttributes":{"countByCommentType":{"CATALYTIC ACTIVITY":8,"COFACTOR":1,"SUBCELLULAR LOCATION":1,"SIMILARITY":1,"CAUTION":1},"countByFeatureType":{"Domain":3,"Region":1,"Compositional bias":2,"Active site":1,"Non-terminal residue":2},"uniParcId":"UPI00053CC8BA"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0A7K8KZQ0","uniProtkbId":"A0A7K8KZQ0_9AVES","entryAudit":{"firstPublicDate":"2021-04-07","lastAnnotationUpdateDate":"2026-11-04","lastSequenceUpdateDate":"2021-04-07","entryVersion":20,"sequenceVersion":1},"annotationScore":5.0,"organism":{"scientificName":"Ardeotis kori","taxonId":89386,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"NXE22479.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000560386"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Archelosauria","Archosauria","Dinosauria","Saurischia","Theropoda","Coelurosauria","Aves","Neognathae","Neoaves","Otidimorphae","Otidiformes","Otididae","Ardeotis"]},"proteinExistence":"4: Predicted","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00014545"}],"value":"Sterol carrier protein 2"},"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00024058"}],"value":"2.3.1.155"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00024073"}],"value":"2.3.1.16"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00012352"}],"value":"2.3.1.176"}]},"alternativeNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00032093"}],"value":"Acetyl-CoA C-myristoyltransferase"}},{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00030851"}],"value":"Non-specific lipid-transfer protein"}},{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00032316"}],"value":"Propanoyl-CoA C-acyltransferase"}},{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00030531"}],"value":"SCP-2/3-oxoacyl-CoA thiolase"}},{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00031275"}],"value":"SCP-2/thiolase"}},{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00031346"}],"value":"SCP-chi"}},{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00033178"}],"value":"Sterol carrier protein X"}}],"flag":"Fragment"},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"NXE22479.1"}],"value":"Scp2_0"},"orfNames":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"NXE22479.1"}],"value":"ARDKOR_R02144"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00045738"}],"value":"Mediates the transfer of all common phospholipids, cholesterol and gangliosides from the endoplasmic reticulum to the plasma membrane. May play a role in regulating steroidogenesis. Stimulates the microsomal conversion of 7-dehydrocholesterol to cholesterol. Also binds fatty acids and fatty acyl Coenzyme A (CoA) such as phytanoyl-CoA. Involved in the regulation phospholipid synthesis in endoplasmic reticulum enhancing the incorporation of exogenous fatty acid into glycerides. Seems to stimulate the rate-limiting step in phosphatidic acid formation mediated by GPAT3. Isoforms SCP2 and SCPx cooperate in peroxisomal oxidation of certain naturally occurring tetramethyl-branched fatty acyl-CoAs"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00045994"}],"value":"Plays a crucial role in the peroxisomal oxidation of branched-chain fatty acids. Catalyzes the last step of the peroxisomal beta-oxidation of branched chain fatty acids and the side chain of the bile acid intermediates di- and trihydroxycoprostanic acids (DHCA and THCA). Also active with medium and long straight chain 3-oxoacyl-CoAs. Stimulates the microsomal conversion of 7-dehydrocholesterol to cholesterol and transfers phosphatidylcholine and 7-dehydrocholesterol between membrances, in vitro. Isoforms SCP2 and SCPx cooperate in peroxisomal oxidation of certain naturally occurring tetramethyl-branched fatty acyl-CoAs"}],"commentType":"FUNCTION"},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"3-oxo-(9Z-octadecenoyl)-CoA + CoA = (7Z)-hexadecenoyl-CoA + acetyl-CoA","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:47400"},{"database":"ChEBI","id":"CHEBI:57287"},{"database":"ChEBI","id":"CHEBI:57288"},{"database":"ChEBI","id":"CHEBI:87695"},{"database":"ChEBI","id":"CHEBI:87698"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00024514"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:47401"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00024514"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"3-oxohexadecanedioyl-CoA + CoA = tetradecanedioyl-CoA + acetyl-CoA","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:40343"},{"database":"ChEBI","id":"CHEBI:57287"},{"database":"ChEBI","id":"CHEBI:57288"},{"database":"ChEBI","id":"CHEBI:77081"},{"database":"ChEBI","id":"CHEBI:77084"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00049306"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:40344"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00049306"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"4,8,12-trimethyltridecanoyl-CoA + propanoyl-CoA = 3-oxopristanoyl-CoA + CoA","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:10408"},{"database":"ChEBI","id":"CHEBI:57287"},{"database":"ChEBI","id":"CHEBI:57291"},{"database":"ChEBI","id":"CHEBI:57351"},{"database":"ChEBI","id":"CHEBI:57392"}],"ecNumber":"2.3.1.176","evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00029348"}]},"physiologicalReactions":[{"directionType":"right-to-left","reactionCrossReference":{"database":"Rhea","id":"RHEA:10410"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00029348"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"7-dehydrocholesterol(in) = 7-dehydrocholesterol(out)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:62960"},{"database":"ChEBI","id":"CHEBI:17759"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00029287"}]}},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"a long-chain fatty acyl-CoA + acetyl-CoA = a long-chain 3-oxo-fatty acyl-CoA + CoA","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:78899"},{"database":"ChEBI","id":"CHEBI:57287"},{"database":"ChEBI","id":"CHEBI:57288"},{"database":"ChEBI","id":"CHEBI:83139"},{"database":"ChEBI","id":"CHEBI:136758"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00095621"}]},"physiologicalReactions":[{"directionType":"right-to-left","reactionCrossReference":{"database":"Rhea","id":"RHEA:78901"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00095621"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"a medium-chain fatty acyl-CoA + acetyl-CoA = a medium-chain 3-oxoacyl-CoA + CoA","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:78903"},{"database":"ChEBI","id":"CHEBI:57287"},{"database":"ChEBI","id":"CHEBI:57288"},{"database":"ChEBI","id":"CHEBI:90546"},{"database":"ChEBI","id":"CHEBI:229604"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00095684"}]},"physiologicalReactions":[{"directionType":"right-to-left","reactionCrossReference":{"database":"Rhea","id":"RHEA:78905"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00095684"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"an acyl-CoA + acetyl-CoA = a 3-oxoacyl-CoA + CoA","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:21564"},{"database":"ChEBI","id":"CHEBI:57287"},{"database":"ChEBI","id":"CHEBI:57288"},{"database":"ChEBI","id":"CHEBI:58342"},{"database":"ChEBI","id":"CHEBI:90726"}],"ecNumber":"2.3.1.16","evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00049178"}]},"physiologicalReactions":[{"directionType":"right-to-left","reactionCrossReference":{"database":"Rhea","id":"RHEA:21566"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00049178"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"butanoyl-CoA + acetyl-CoA = 3-oxohexanoyl-CoA + CoA","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:31111"},{"database":"ChEBI","id":"CHEBI:57287"},{"database":"ChEBI","id":"CHEBI:57288"},{"database":"ChEBI","id":"CHEBI:57371"},{"database":"ChEBI","id":"CHEBI:62418"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00048553"}]},"physiologicalReactions":[{"directionType":"right-to-left","reactionCrossReference":{"database":"Rhea","id":"RHEA:31113"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00048553"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"choloyl-CoA + propanoyl-CoA = 3alpha,7alpha,12alpha-trihydroxy-24-oxo-5beta-cholestan-26-oyl-CoA + CoA","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:16865"},{"database":"ChEBI","id":"CHEBI:57287"},{"database":"ChEBI","id":"CHEBI:57373"},{"database":"ChEBI","id":"CHEBI:57392"},{"database":"ChEBI","id":"CHEBI:58507"}],"ecNumber":"2.3.1.176","evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00024509"}]},"physiologicalReactions":[{"directionType":"right-to-left","reactionCrossReference":{"database":"Rhea","id":"RHEA:16867"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00024509"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"decanoyl-CoA + acetyl-CoA = 3-oxododecanoyl-CoA + CoA","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:31183"},{"database":"ChEBI","id":"CHEBI:57287"},{"database":"ChEBI","id":"CHEBI:57288"},{"database":"ChEBI","id":"CHEBI:61430"},{"database":"ChEBI","id":"CHEBI:62615"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00048004"}]},"physiologicalReactions":[{"directionType":"right-to-left","reactionCrossReference":{"database":"Rhea","id":"RHEA:31185"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00048004"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"dodecanoyl-CoA + acetyl-CoA = 3-oxotetradecanoyl-CoA + CoA","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:31091"},{"database":"ChEBI","id":"CHEBI:57287"},{"database":"ChEBI","id":"CHEBI:57288"},{"database":"ChEBI","id":"CHEBI:57375"},{"database":"ChEBI","id":"CHEBI:62543"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00049270"}]},"physiologicalReactions":[{"directionType":"right-to-left","reactionCrossReference":{"database":"Rhea","id":"RHEA:31093"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00049270"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"hexadecanoyl-CoA + acetyl-CoA = 3-oxooctadecanoyl-CoA + CoA","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:35279"},{"database":"ChEBI","id":"CHEBI:57287"},{"database":"ChEBI","id":"CHEBI:57288"},{"database":"ChEBI","id":"CHEBI:57379"},{"database":"ChEBI","id":"CHEBI:71407"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00049268"}]},"physiologicalReactions":[{"directionType":"right-to-left","reactionCrossReference":{"database":"Rhea","id":"RHEA:35281"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00049268"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"hexanoyl-CoA + acetyl-CoA = 3-oxooctanoyl-CoA + CoA","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:31203"},{"database":"ChEBI","id":"CHEBI:57287"},{"database":"ChEBI","id":"CHEBI:57288"},{"database":"ChEBI","id":"CHEBI:62619"},{"database":"ChEBI","id":"CHEBI:62620"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00048001"}]},"physiologicalReactions":[{"directionType":"right-to-left","reactionCrossReference":{"database":"Rhea","id":"RHEA:31205"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00048001"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"octanoyl-CoA + acetyl-CoA = 3-oxodecanoyl-CoA + CoA","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:31087"},{"database":"ChEBI","id":"CHEBI:57287"},{"database":"ChEBI","id":"CHEBI:57288"},{"database":"ChEBI","id":"CHEBI:57386"},{"database":"ChEBI","id":"CHEBI:62548"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00049542"}]},"physiologicalReactions":[{"directionType":"right-to-left","reactionCrossReference":{"database":"Rhea","id":"RHEA:31089"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00049542"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"propanoyl-CoA + tetradecanoyl-CoA = 3-oxo-2-methylhexadecanoyl-CoA + CoA","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:46344"},{"database":"ChEBI","id":"CHEBI:57287"},{"database":"ChEBI","id":"CHEBI:57385"},{"database":"ChEBI","id":"CHEBI:57392"},{"database":"ChEBI","id":"CHEBI:86042"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00024471"}]},"physiologicalReactions":[{"directionType":"right-to-left","reactionCrossReference":{"database":"Rhea","id":"RHEA:46346"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00024471"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"tetradecanoyl-CoA + acetyl-CoA = 3-oxohexadecanoyl-CoA + CoA","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:18161"},{"database":"ChEBI","id":"CHEBI:57287"},{"database":"ChEBI","id":"CHEBI:57288"},{"database":"ChEBI","id":"CHEBI:57349"},{"database":"ChEBI","id":"CHEBI:57385"}],"ecNumber":"2.3.1.155","evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00047485"}]},"physiologicalReactions":[{"directionType":"right-to-left","reactionCrossReference":{"database":"Rhea","id":"RHEA:18163"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00047485"}]}]},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004496"}],"value":"Cytoplasm","id":"SL-0086"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"NXE22479.1"}],"value":"The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data"}],"commentType":"CAUTION"}],"features":[{"type":"Domain","location":{"start":{"value":55,"modifier":"EXACT"},"end":{"value":182,"modifier":"EXACT"}},"description":"Thiolase C-terminal","evidences":[{"evidenceCode":"ECO:0000259","source":"Pfam","id":"PF22691"}]},{"type":"Domain","location":{"start":{"value":218,"modifier":"EXACT"},"end":{"value":319,"modifier":"EXACT"}},"description":"SCP2","evidences":[{"evidenceCode":"ECO:0000259","source":"Pfam","id":"PF02036"}]},{"type":"Non-terminal residue","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":1,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"NXE22479.1"}]},{"type":"Non-terminal residue","location":{"start":{"value":328,"modifier":"EXACT"},"end":{"value":328,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"NXE22479.1"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023315"}],"id":"KW-0012","category":"Molecular function","name":"Acyltransferase"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022490"}],"id":"KW-0963","category":"Cellular component","name":"Cytoplasm"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023098"}],"id":"KW-0443","category":"Biological process","name":"Lipid metabolism"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023055"}],"id":"KW-0445","category":"Biological process","name":"Lipid transport"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023121"}],"id":"KW-0446","category":"Ligand","name":"Lipid-binding"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000560386"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023315"}],"id":"KW-0808","category":"Molecular function","name":"Transferase"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022448"}],"id":"KW-0813","category":"Biological process","name":"Transport"}],"references":[{"referenceNumber":1,"citation":{"id":"CI-90S2KOISV381S","citationType":"submission","authors":["Zhang G."],"title":"Bird 10,000 Genomes (B10K) Project - Family phase.","publicationDate":"SEP-2019","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"NXE22479.1"}],"value":"B10K-CU-031-01","type":"STRAIN"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"NXE22479.1"}],"value":"Muscle","type":"TISSUE"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"NXE22479.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000560386"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"VWPR01000350","properties":[{"key":"ProteinId","value":"NXE22479.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"AlphaFoldDB","id":"A0A7K8KZQ0","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000560386","properties":[{"key":"Component","value":"Unassembled WGS sequence"}]},{"database":"GO","id":"GO:0005737","properties":[{"key":"GoTerm","value":"C:cytoplasm"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0003988","properties":[{"key":"GoTerm","value":"F:acetyl-CoA C-acyltransferase activity"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-EC"}]},{"database":"GO","id":"GO:0050633","properties":[{"key":"GoTerm","value":"F:acetyl-CoA C-myristoyltransferase activity"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-EC"}]},{"database":"FunFam","id":"3.30.1050.10:FF:000001","properties":[{"key":"EntryName","value":"Putative Non-specific lipid-transfer protein"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.40.47.10","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.30.1050.10","properties":[{"key":"EntryName","value":"SCP2 sterol-binding domain"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR003033","properties":[{"key":"EntryName","value":"SCP2_sterol-bd_dom"}]},{"database":"InterPro","id":"IPR036527","properties":[{"key":"EntryName","value":"SCP2_sterol-bd_dom_sf"}]},{"database":"InterPro","id":"IPR016039","properties":[{"key":"EntryName","value":"Thiolase-like"}]},{"database":"InterPro","id":"IPR055140","properties":[{"key":"EntryName","value":"Thiolase_C_2"}]},{"database":"InterPro","id":"IPR020613","properties":[{"key":"EntryName","value":"Thiolase_CS"}]},{"database":"PANTHER","id":"PTHR42870","properties":[{"key":"EntryName","value":"ACETYL-COA C-ACETYLTRANSFERASE"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR42870:SF1","properties":[{"key":"EntryName","value":"NON-SPECIFIC LIPID-TRANSFER PROTEIN-LIKE 2"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF02036","properties":[{"key":"EntryName","value":"SCP2"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF22691","properties":[{"key":"EntryName","value":"Thiolase_C_1"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF55718","properties":[{"key":"EntryName","value":"SCP-like"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF53901","properties":[{"key":"EntryName","value":"Thiolase-like"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00737","properties":[{"key":"EntryName","value":"THIOLASE_2"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"DIIVFLSISPTSNGAAAAILASEEFVKRHKLQPKAVEILAQVMATDYPSTFEENSCMKMVGYDMTKKAAEKCFEKAGLKPTDVDVIELHDCFSVNEFITYEALGLCPEGKACDLIDRGDNTYGGKWVINPSGGLISKGHPLGATGLAQCAELCWQLRGLAGRRQVPGAKVALQHNLGLGGAAVVTLYGMGFPGAASTGRIAAVPLSAAVDGFKSHLVFKEIEKKLQEEGEQFVKKIGGIFAFKIKDGPNGKEATWVVDVKNGKGSVAVNSDKKADCTITMADADLLALMTGKMNPQTAFFQGKLKISGNMGMAMKLQNLQLQPGKAKL","length":328,"molWeight":34915,"crc64":"805968AFDEA64214","md5":"96A2E1FB6A911CDFFE744AAD893DE5D5"},"extraAttributes":{"countByCommentType":{"FUNCTION":2,"CATALYTIC ACTIVITY":16,"SUBCELLULAR LOCATION":1,"CAUTION":1},"countByFeatureType":{"Domain":2,"Non-terminal residue":2},"uniParcId":"UPI0017E75E5F"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0A7K8KZV6","uniProtkbId":"A0A7K8KZV6_9AVES","entryAudit":{"firstPublicDate":"2021-04-07","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2021-04-07","entryVersion":16,"sequenceVersion":1},"annotationScore":5.0,"organism":{"scientificName":"Ardeotis kori","taxonId":89386,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"NXE21743.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000560386"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Archelosauria","Archosauria","Dinosauria","Saurischia","Theropoda","Coelurosauria","Aves","Neognathae","Neoaves","Otidimorphae","Otidiformes","Otididae","Ardeotis"]},"proteinExistence":"3: Inferred from homology","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00020651"}],"value":"Prostaglandin reductase 1"},"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00011981"}],"value":"1.3.1.48"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00012410"}],"value":"1.3.1.74"}]},"alternativeNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00033119"}],"value":"15-oxoprostaglandin 13-reductase"}},{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00032255"}],"value":"Dithiolethione-inducible gene 1 protein"}},{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00031851"}],"value":"Leukotriene B4 12-hydroxydehydrogenase"}},{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00032297"}],"value":"NAD(P)H-dependent alkenal/one oxidoreductase"}}],"flag":"Fragment"},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"NXE21743.1"}],"value":"Ptgr1"},"orfNames":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"NXE21743.1"}],"value":"ARDKOR_R01079"}]}],"comments":[{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"(5S,12S)-dihydroxy-(6E,10E,12E,14Z)-eicosatetraenoate + NADP(+) = 12-oxo-(5S)-hydroxy-(6E,8E,10E,14Z)-eicosatetraenoate + NADPH + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:51212"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:57783"},{"database":"ChEBI","id":"CHEBI:58349"},{"database":"ChEBI","id":"CHEBI:133974"},{"database":"ChEBI","id":"CHEBI:133975"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00049068"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:51213"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00049068"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"13,14-dihydro-15-oxo-PGF2alpha + NADP(+) = 15-oxoprostaglandin F2alpha + NADPH + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:50588"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:57783"},{"database":"ChEBI","id":"CHEBI:58349"},{"database":"ChEBI","id":"CHEBI:133374"},{"database":"ChEBI","id":"CHEBI:133409"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00048290"}]},"physiologicalReactions":[{"directionType":"right-to-left","reactionCrossReference":{"database":"Rhea","id":"RHEA:50590"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00048290"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"13,14-dihydro-15-oxo-prostaglandin E1 + NADP(+) = 15-oxoprostaglandin E1 + NADPH + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:50584"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:57401"},{"database":"ChEBI","id":"CHEBI:57783"},{"database":"ChEBI","id":"CHEBI:58349"},{"database":"ChEBI","id":"CHEBI:133408"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00049070"}]},"physiologicalReactions":[{"directionType":"right-to-left","reactionCrossReference":{"database":"Rhea","id":"RHEA:50586"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00049070"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"13,14-dihydro-15-oxo-prostaglandin F1alpha + NADP(+) = 15-oxoprostaglandin F1alpha + NADPH + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:50592"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:57783"},{"database":"ChEBI","id":"CHEBI:58349"},{"database":"ChEBI","id":"CHEBI:79072"},{"database":"ChEBI","id":"CHEBI:133411"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00047878"}]},"physiologicalReactions":[{"directionType":"right-to-left","reactionCrossReference":{"database":"Rhea","id":"RHEA:50594"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00047878"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"20-hydroxy-leukotriene B4 + NADP(+) = 12-oxo-20-hydroxy-leukotriene B4 + NADPH + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:51208"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:57460"},{"database":"ChEBI","id":"CHEBI:57783"},{"database":"ChEBI","id":"CHEBI:58349"},{"database":"ChEBI","id":"CHEBI:133346"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00048591"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:51209"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00048591"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"4-hydroxynonanal + NADP(+) = (E)-4-hydroxynon-2-enal + NADPH + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:64736"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:57783"},{"database":"ChEBI","id":"CHEBI:58349"},{"database":"ChEBI","id":"CHEBI:58968"},{"database":"ChEBI","id":"CHEBI:156112"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00048387"}]},"physiologicalReactions":[{"directionType":"right-to-left","reactionCrossReference":{"database":"Rhea","id":"RHEA:64738"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00048387"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"6-trans-leukotriene B4 + NADP(+) = 12-oxo-(5S)-hydroxy-(6E,8E,10E,14Z)-eicosatetraenoate + NADPH + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:51204"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:57783"},{"database":"ChEBI","id":"CHEBI:58349"},{"database":"ChEBI","id":"CHEBI:90723"},{"database":"ChEBI","id":"CHEBI:133974"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00048953"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:51205"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00048953"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"an n-alkanal + NADP(+) = an alk-2-enal + NADPH + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:13737"},{"database":"ChEBI","id":"CHEBI:12834"},{"database":"ChEBI","id":"CHEBI:13757"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:57783"},{"database":"ChEBI","id":"CHEBI:58349"}],"ecNumber":"1.3.1.74","evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00049179"}]},"physiologicalReactions":[{"directionType":"right-to-left","reactionCrossReference":{"database":"Rhea","id":"RHEA:13739"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00049179"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"decanal + NADP(+) = (2E)-decenal + NADPH + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:50612"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:31457"},{"database":"ChEBI","id":"CHEBI:57783"},{"database":"ChEBI","id":"CHEBI:58349"},{"database":"ChEBI","id":"CHEBI:133455"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00047617"}]},"physiologicalReactions":[{"directionType":"right-to-left","reactionCrossReference":{"database":"Rhea","id":"RHEA:50614"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00047617"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"dodecanal + NADP(+) = (2E)-dodecenal + NADPH + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:50784"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:27836"},{"database":"ChEBI","id":"CHEBI:57783"},{"database":"ChEBI","id":"CHEBI:58349"},{"database":"ChEBI","id":"CHEBI:133741"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00047903"}]},"physiologicalReactions":[{"directionType":"right-to-left","reactionCrossReference":{"database":"Rhea","id":"RHEA:50786"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00047903"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"hexanal + NADP(+) = (E)-hex-2-enal + NADPH + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:50776"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:28913"},{"database":"ChEBI","id":"CHEBI:57783"},{"database":"ChEBI","id":"CHEBI:58349"},{"database":"ChEBI","id":"CHEBI:88528"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00049368"}]},"physiologicalReactions":[{"directionType":"right-to-left","reactionCrossReference":{"database":"Rhea","id":"RHEA:50778"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00049368"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"leukotriene B4 + NADP(+) = 12-oxo-leukotriene B4 + NADPH + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:50608"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:57461"},{"database":"ChEBI","id":"CHEBI:57783"},{"database":"ChEBI","id":"CHEBI:58349"},{"database":"ChEBI","id":"CHEBI:133309"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00047871"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:50609"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00047871"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"nonan-2-one + NADP(+) = (3E)-nonen-2-one + NADPH + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:50616"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:57783"},{"database":"ChEBI","id":"CHEBI:58349"},{"database":"ChEBI","id":"CHEBI:77927"},{"database":"ChEBI","id":"CHEBI:133457"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00048066"}]},"physiologicalReactions":[{"directionType":"right-to-left","reactionCrossReference":{"database":"Rhea","id":"RHEA:50618"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00048066"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"octanal + NADP(+) = (2E)-octenal + NADPH + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:50780"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:17935"},{"database":"ChEBI","id":"CHEBI:57783"},{"database":"ChEBI","id":"CHEBI:58349"},{"database":"ChEBI","id":"CHEBI:61748"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00047461"}]},"physiologicalReactions":[{"directionType":"right-to-left","reactionCrossReference":{"database":"Rhea","id":"RHEA:50782"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00047461"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"pentan-2-one + NADP(+) = (E)-pent-3-en-2-one + NADPH + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:50788"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:16472"},{"database":"ChEBI","id":"CHEBI:57783"},{"database":"ChEBI","id":"CHEBI:58349"},{"database":"ChEBI","id":"CHEBI:145276"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00047742"}]},"physiologicalReactions":[{"directionType":"right-to-left","reactionCrossReference":{"database":"Rhea","id":"RHEA:50790"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00047742"}]}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00011852"}],"value":"Monomer or homodimer"}],"commentType":"SUBUNIT"},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004496"}],"value":"Cytoplasm","id":"SL-0086"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00010460"}],"value":"Belongs to the NADP-dependent oxidoreductase L4BD family"}],"commentType":"SIMILARITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"NXE21743.1"}],"value":"The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data"}],"commentType":"CAUTION"}],"features":[{"type":"Domain","location":{"start":{"value":40,"modifier":"EXACT"},"end":{"value":330,"modifier":"EXACT"}},"description":"Enoyl reductase (ER)","evidences":[{"evidenceCode":"ECO:0000259","source":"SMART","id":"SM00829"}]},{"type":"Non-terminal residue","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":1,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"NXE21743.1"}]},{"type":"Non-terminal residue","location":{"start":{"value":332,"modifier":"EXACT"},"end":{"value":332,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"NXE21743.1"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022990"}],"id":"KW-0007","category":"PTM","name":"Acetylation"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022490"}],"id":"KW-0963","category":"Cellular component","name":"Cytoplasm"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022832"}],"id":"KW-0276","category":"Biological process","name":"Fatty acid metabolism"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023278"}],"id":"KW-0379","category":"PTM","name":"Hydroxylation"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023098"}],"id":"KW-0443","category":"Biological process","name":"Lipid metabolism"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022857"}],"id":"KW-0521","category":"Ligand","name":"NADP"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023002"}],"id":"KW-0560","category":"Molecular function","name":"Oxidoreductase"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022553"}],"id":"KW-0597","category":"PTM","name":"Phosphoprotein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022501"}],"id":"KW-0644","category":"Biological process","name":"Prostaglandin metabolism"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000560386"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"}],"references":[{"referenceNumber":1,"citation":{"id":"CI-90S2KOISV381S","citationType":"submission","authors":["Zhang G."],"title":"Bird 10,000 Genomes (B10K) Project - Family phase.","publicationDate":"SEP-2019","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"NXE21743.1"}],"value":"B10K-CU-031-01","type":"STRAIN"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"NXE21743.1"}],"value":"Muscle","type":"TISSUE"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"NXE21743.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000560386"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"VWPR01000259","properties":[{"key":"ProteinId","value":"NXE21743.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"AlphaFoldDB","id":"A0A7K8KZV6","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000560386","properties":[{"key":"Component","value":"Unassembled WGS sequence"}]},{"database":"GO","id":"GO:0005737","properties":[{"key":"GoTerm","value":"C:cytoplasm"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0047522","properties":[{"key":"GoTerm","value":"F:15-oxoprostaglandin 13-reductase [NAD(P)+] activity"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-EC"}]},{"database":"GO","id":"GO:0032440","properties":[{"key":"GoTerm","value":"F:2-alkenal reductase [NAD(P)H] activity"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-EC"}]},{"database":"GO","id":"GO:0006693","properties":[{"key":"GoTerm","value":"P:prostaglandin metabolic process"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"CDD","id":"cd08294","properties":[{"key":"EntryName","value":"leukotriene_B4_DH_like"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.40.50.720:FF:000121","properties":[{"key":"EntryName","value":"Prostaglandin reductase 2"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.90.180.10","properties":[{"key":"EntryName","value":"Medium-chain alcohol dehydrogenases, catalytic domain"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.40.50.720","properties":[{"key":"EntryName","value":"NAD(P)-binding Rossmann-like Domain"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR013149","properties":[{"key":"EntryName","value":"ADH-like_C"}]},{"database":"InterPro","id":"IPR041694","properties":[{"key":"EntryName","value":"ADH_N_2"}]},{"database":"InterPro","id":"IPR020843","properties":[{"key":"EntryName","value":"ER"}]},{"database":"InterPro","id":"IPR011032","properties":[{"key":"EntryName","value":"GroES-like_sf"}]},{"database":"InterPro","id":"IPR045010","properties":[{"key":"EntryName","value":"MDR_fam"}]},{"database":"InterPro","id":"IPR036291","properties":[{"key":"EntryName","value":"NAD(P)-bd_dom_sf"}]},{"database":"InterPro","id":"IPR014190","properties":[{"key":"EntryName","value":"PTGR1"}]},{"database":"PANTHER","id":"PTHR43205","properties":[{"key":"EntryName","value":"PROSTAGLANDIN REDUCTASE"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR43205:SF7","properties":[{"key":"EntryName","value":"PROSTAGLANDIN REDUCTASE 1"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF16884","properties":[{"key":"EntryName","value":"ADH_N_2"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00107","properties":[{"key":"EntryName","value":"ADH_zinc_N"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00829","properties":[{"key":"EntryName","value":"PKS_ER"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF50129","properties":[{"key":"EntryName","value":"GroES-like"},{"key":"MatchStatus","value":"2"}]},{"database":"SUPFAM","id":"SSF51735","properties":[{"key":"EntryName","value":"NAD(P)-binding Rossmann-fold domains"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MVTAKAWVLKKHFEGFPKTSDFDLKKIELPDLKDGGKWKLLLESVFLSVDPYMRPYSRRDMKEGDIMIGTQVARIVESKNPAFTVGAFVVGRSGWRTHFISDGKDLELLPSSWPESLPKSLALGTVGMPGLTAYFGLMEVCKMKPGETVLVNAAAGAVGSVVGQLAKIGGCKVVGCAGSDDKVAYLKKLGFDEAFNYKTVPSLDEALRKASPDGYDCFFDNVGGEFASIAINHMKKYGRIAVCGAISQYNDSVPQKGPYIQIPMIFKELRIEGFMVFRWNNRREEGLKALLKWVMEGKVKCHEQVTEGFENMPMAFIGMLKGENIGKAIVKV","length":332,"molWeight":36628,"crc64":"FF5E35B55D11F6AE","md5":"CF189E0247ADA4015A196D3DD85059D7"},"extraAttributes":{"countByCommentType":{"CATALYTIC ACTIVITY":15,"SUBUNIT":1,"SUBCELLULAR LOCATION":1,"SIMILARITY":1,"CAUTION":1},"countByFeatureType":{"Domain":1,"Non-terminal residue":2},"uniParcId":"UPI0017EBC6C8"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0A7K8L0P0","uniProtkbId":"A0A7K8L0P0_9AVES","entryAudit":{"firstPublicDate":"2021-04-07","lastAnnotationUpdateDate":"2026-11-04","lastSequenceUpdateDate":"2021-04-07","entryVersion":26,"sequenceVersion":1},"annotationScore":5.0,"organism":{"scientificName":"Ardeotis kori","taxonId":89386,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"NXE22023.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000560386"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Archelosauria","Archosauria","Dinosauria","Saurischia","Theropoda","Coelurosauria","Aves","Neognathae","Neoaves","Otidimorphae","Otidiformes","Otididae","Ardeotis"]},"proteinExistence":"3: Inferred from homology","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00072791"}],"value":"Angiopoietin-1 receptor"},"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00011902"}],"value":"2.7.10.1"}]},"alternativeNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00075340"}],"value":"Endothelial tyrosine kinase"}},{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00082816"}],"value":"Tyrosine kinase with Ig and EGF homology domains-2"}},{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00078633"}],"value":"Tyrosine-protein kinase receptor TIE-2"}}],"flag":"Fragment"},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"NXE22023.1"}],"value":"Tek"},"orfNames":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"NXE22023.1"}],"value":"ARDKOR_R09886"}]}],"comments":[{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:10596"},{"database":"Rhea","id":"RHEA-COMP:10136"},{"database":"Rhea","id":"RHEA-COMP:20101"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:30616"},{"database":"ChEBI","id":"CHEBI:46858"},{"database":"ChEBI","id":"CHEBI:61978"},{"database":"ChEBI","id":"CHEBI:456216"}],"ecNumber":"2.7.10.1","evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00051243"}]}},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004246"}],"value":"Cell junction, focal adhesion","id":"SL-0118"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004251"}],"value":"Cell membrane","id":"SL-0039"},"topology":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004251"}],"value":"Single-pass type I membrane protein","id":"SL-9905"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004245"}],"value":"Cytoplasm, cytoskeleton","id":"SL-0090"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004613"}],"value":"Secreted","id":"SL-0243"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00159"}],"value":"Belongs to the protein kinase superfamily. Tyr protein kinase family"}],"commentType":"SIMILARITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00076"}],"value":"Lacks conserved residue(s) required for the propagation of feature annotation"}],"commentType":"CAUTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"NXE22023.1"}],"value":"The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data"}],"commentType":"CAUTION"}],"features":[{"type":"Transmembrane","location":{"start":{"value":741,"modifier":"EXACT"},"end":{"value":765,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Domain","location":{"start":{"value":208,"modifier":"EXACT"},"end":{"value":244,"modifier":"EXACT"}},"description":"EGF-like","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50026"}]},{"type":"Domain","location":{"start":{"value":342,"modifier":"EXACT"},"end":{"value":432,"modifier":"EXACT"}},"description":"Ig-like","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50835"}]},{"type":"Domain","location":{"start":{"value":439,"modifier":"EXACT"},"end":{"value":533,"modifier":"EXACT"}},"description":"Fibronectin type-III","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50853"}]},{"type":"Domain","location":{"start":{"value":537,"modifier":"EXACT"},"end":{"value":631,"modifier":"EXACT"}},"description":"Fibronectin type-III","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50853"}]},{"type":"Domain","location":{"start":{"value":636,"modifier":"EXACT"},"end":{"value":729,"modifier":"EXACT"}},"description":"Fibronectin type-III","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50853"}]},{"type":"Domain","location":{"start":{"value":819,"modifier":"EXACT"},"end":{"value":1091,"modifier":"EXACT"}},"description":"Protein kinase","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50011"}]},{"type":"Active site","location":{"start":{"value":959,"modifier":"EXACT"},"end":{"value":959,"modifier":"EXACT"}},"description":"Proton acceptor","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU10028"}]},{"type":"Binding site","location":{"start":{"value":850,"modifier":"EXACT"},"end":{"value":850,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:30616"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU10141"}],"ligand":{"name":"ATP","id":"ChEBI:CHEBI:30616"}},{"type":"Disulfide bond","location":{"start":{"value":234,"modifier":"EXACT"},"end":{"value":243,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00076"}]},{"type":"Disulfide bond","location":{"start":{"value":363,"modifier":"EXACT"},"end":{"value":416,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00114"}]},{"type":"Non-terminal residue","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":1,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"NXE22023.1"}]},{"type":"Non-terminal residue","location":{"start":{"value":1119,"modifier":"EXACT"},"end":{"value":1119,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"NXE22023.1"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022840"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU10141"}],"id":"KW-0067","category":"Ligand","name":"ATP-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022949"}],"id":"KW-0965","category":"Cellular component","name":"Cell junction"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022475"}],"id":"KW-1003","category":"Cellular component","name":"Cell membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022490"}],"id":"KW-0963","category":"Cellular component","name":"Cytoplasm"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023212"}],"id":"KW-0206","category":"Cellular component","name":"Cytoskeleton"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023157"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00076"}],"id":"KW-1015","category":"PTM","name":"Disulfide bond"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022536"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00076"}],"id":"KW-0245","category":"Domain","name":"EGF-like domain"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023180"}],"id":"KW-0325","category":"PTM","name":"Glycoprotein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023319"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00114"}],"id":"KW-0393","category":"Domain","name":"Immunoglobulin domain"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022777"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00159"}],"id":"KW-0418","category":"Molecular function","name":"Kinase"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023136"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022741"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU10141"}],"id":"KW-0547","category":"Ligand","name":"Nucleotide-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022553"}],"id":"KW-0597","category":"PTM","name":"Phosphoprotein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023170"}],"id":"KW-0675","category":"Molecular function","name":"Receptor"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000560386"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022737"}],"id":"KW-0677","category":"Domain","name":"Repeat"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022525"}],"id":"KW-0964","category":"Cellular component","name":"Secreted"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022729"}],"id":"KW-0732","category":"Domain","name":"Signal"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022679"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00159"}],"id":"KW-0808","category":"Molecular function","name":"Transferase"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022692"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022989"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-1133","category":"Domain","name":"Transmembrane helix"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023137"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00159"}],"id":"KW-0829","category":"Molecular function","name":"Tyrosine-protein kinase"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022843"}],"id":"KW-0832","category":"PTM","name":"Ubl conjugation"}],"references":[{"referenceNumber":1,"citation":{"id":"CI-90S2KOISV381S","citationType":"submission","authors":["Zhang G."],"title":"Bird 10,000 Genomes (B10K) Project - Family phase.","publicationDate":"SEP-2019","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"NXE22023.1"}],"value":"B10K-CU-031-01","type":"STRAIN"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"NXE22023.1"}],"value":"Muscle","type":"TISSUE"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"NXE22023.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000560386"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"VWPR01000287","properties":[{"key":"ProteinId","value":"NXE22023.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"AlphaFoldDB","id":"A0A7K8L0P0","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000560386","properties":[{"key":"Component","value":"Unassembled WGS sequence"}]},{"database":"GO","id":"GO:0005856","properties":[{"key":"GoTerm","value":"C:cytoskeleton"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0005576","properties":[{"key":"GoTerm","value":"C:extracellular region"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0005925","properties":[{"key":"GoTerm","value":"C:focal adhesion"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0005886","properties":[{"key":"GoTerm","value":"C:plasma membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0043235","properties":[{"key":"GoTerm","value":"C:signaling receptor complex"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:0005524","properties":[{"key":"GoTerm","value":"F:ATP binding"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniRule"}]},{"database":"GO","id":"GO:0004714","properties":[{"key":"GoTerm","value":"F:transmembrane receptor protein tyrosine kinase activity"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-EC"}]},{"database":"GO","id":"GO:0001525","properties":[{"key":"GoTerm","value":"P:angiogenesis"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:0007169","properties":[{"key":"GoTerm","value":"P:cell surface receptor protein tyrosine kinase signaling pathway"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0031589","properties":[{"key":"GoTerm","value":"P:cell-substrate adhesion"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0001935","properties":[{"key":"GoTerm","value":"P:endothelial cell proliferation"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:0030097","properties":[{"key":"GoTerm","value":"P:hemopoiesis"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0043066","properties":[{"key":"GoTerm","value":"P:negative regulation of apoptotic process"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0045766","properties":[{"key":"GoTerm","value":"P:positive regulation of angiogenesis"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:0045785","properties":[{"key":"GoTerm","value":"P:positive regulation of cell adhesion"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0010595","properties":[{"key":"GoTerm","value":"P:positive regulation of endothelial cell migration"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:0043410","properties":[{"key":"GoTerm","value":"P:positive regulation of MAPK cascade"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:0051897","properties":[{"key":"GoTerm","value":"P:positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:2000351","properties":[{"key":"GoTerm","value":"P:regulation of endothelial cell apoptotic process"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0001936","properties":[{"key":"GoTerm","value":"P:regulation of endothelial cell proliferation"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"CDD","id":"cd00054","properties":[{"key":"EntryName","value":"EGF_CA"},{"key":"MatchStatus","value":"1"}]},{"database":"CDD","id":"cd00055","properties":[{"key":"EntryName","value":"EGF_Lam"},{"key":"MatchStatus","value":"1"}]},{"database":"CDD","id":"cd00063","properties":[{"key":"EntryName","value":"FN3"},{"key":"MatchStatus","value":"2"}]},{"database":"CDD","id":"cd05088","properties":[{"key":"EntryName","value":"PTKc_Tie2"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.60.40.10:FF:000397","properties":[{"key":"EntryName","value":"angiopoietin-1 receptor isoform X1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.60.40.10:FF:000407","properties":[{"key":"EntryName","value":"angiopoietin-1 receptor isoform X1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.60.40.10:FF:000406","properties":[{"key":"EntryName","value":"angiopoietin-1 receptor isoform X2"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.30.200.20:FF:000113","properties":[{"key":"EntryName","value":"Putative tyrosine-protein kinase receptor Tie-1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.60.40.10:FF:000388","properties":[{"key":"EntryName","value":"TEK receptor tyrosine kinase"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.60.40.10:FF:000391","properties":[{"key":"EntryName","value":"TEK receptor tyrosine kinase"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.10.510.10:FF:000123","properties":[{"key":"EntryName","value":"Tyrosine-protein kinase receptor Tie-1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.170.300.10:FF:000003","properties":[{"key":"EntryName","value":"tyrosine-protein kinase receptor Tie-1 isoform X1"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.60.40.10","properties":[{"key":"EntryName","value":"Immunoglobulins"},{"key":"MatchStatus","value":"6"}]},{"database":"Gene3D","id":"3.30.200.20","properties":[{"key":"EntryName","value":"Phosphorylase Kinase, domain 1"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.170.300.10","properties":[{"key":"EntryName","value":"Tie2 ligand-binding domain superfamily"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.10.510.10","properties":[{"key":"EntryName","value":"Transferase(Phosphotransferase) domain 1"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR000742","properties":[{"key":"EntryName","value":"EGF"}]},{"database":"InterPro","id":"IPR013111","properties":[{"key":"EntryName","value":"EGF_extracell"}]},{"database":"InterPro","id":"IPR003961","properties":[{"key":"EntryName","value":"FN3_dom"}]},{"database":"InterPro","id":"IPR036116","properties":[{"key":"EntryName","value":"FN3_sf"}]},{"database":"InterPro","id":"IPR007110","properties":[{"key":"EntryName","value":"Ig-like_dom"}]},{"database":"InterPro","id":"IPR036179","properties":[{"key":"EntryName","value":"Ig-like_dom_sf"}]},{"database":"InterPro","id":"IPR013783","properties":[{"key":"EntryName","value":"Ig-like_fold"}]},{"database":"InterPro","id":"IPR011009","properties":[{"key":"EntryName","value":"Kinase-like_dom_sf"}]},{"database":"InterPro","id":"IPR002049","properties":[{"key":"EntryName","value":"LE_dom"}]},{"database":"InterPro","id":"IPR000719","properties":[{"key":"EntryName","value":"Prot_kinase_dom"}]},{"database":"InterPro","id":"IPR017441","properties":[{"key":"EntryName","value":"Protein_kinase_ATP_BS"}]},{"database":"InterPro","id":"IPR050122","properties":[{"key":"EntryName","value":"RTK"}]},{"database":"InterPro","id":"IPR001245","properties":[{"key":"EntryName","value":"Ser-Thr/Tyr_kinase_cat_dom"}]},{"database":"InterPro","id":"IPR018941","properties":[{"key":"EntryName","value":"Tyr_kin_Tie2_Ig-like_dom-1_N"}]},{"database":"InterPro","id":"IPR008266","properties":[{"key":"EntryName","value":"Tyr_kinase_AS"}]},{"database":"InterPro","id":"IPR020635","properties":[{"key":"EntryName","value":"Tyr_kinase_cat_dom"}]},{"database":"PANTHER","id":"PTHR24416:SF125","properties":[{"key":"EntryName","value":"ANGIOPOIETIN-1 RECEPTOR"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR24416","properties":[{"key":"EntryName","value":"TYROSINE-PROTEIN KINASE RECEPTOR"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF07974","properties":[{"key":"EntryName","value":"EGF_2"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00041","properties":[{"key":"EntryName","value":"fn3"},{"key":"MatchStatus","value":"2"}]},{"database":"Pfam","id":"PF10430","properties":[{"key":"EntryName","value":"Ig_Tie2_1"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF07714","properties":[{"key":"EntryName","value":"PK_Tyr_Ser-Thr"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR00109","properties":[{"key":"EntryName","value":"TYRKINASE"}]},{"database":"SMART","id":"SM00060","properties":[{"key":"EntryName","value":"FN3"},{"key":"MatchStatus","value":"3"}]},{"database":"SMART","id":"SM00219","properties":[{"key":"EntryName","value":"TyrKc"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF49265","properties":[{"key":"EntryName","value":"Fibronectin type III"},{"key":"MatchStatus","value":"2"}]},{"database":"SUPFAM","id":"SSF48726","properties":[{"key":"EntryName","value":"Immunoglobulin"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF56112","properties":[{"key":"EntryName","value":"Protein kinase-like (PK-like)"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00022","properties":[{"key":"EntryName","value":"EGF_1"},{"key":"MatchStatus","value":"3"}]},{"database":"PROSITE","id":"PS01186","properties":[{"key":"EntryName","value":"EGF_2"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50026","properties":[{"key":"EntryName","value":"EGF_3"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50853","properties":[{"key":"EntryName","value":"FN3"},{"key":"MatchStatus","value":"3"}]},{"database":"PROSITE","id":"PS50835","properties":[{"key":"EntryName","value":"IG_LIKE"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00107","properties":[{"key":"EntryName","value":"PROTEIN_KINASE_ATP"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50011","properties":[{"key":"EntryName","value":"PROTEIN_KINASE_DOM"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00109","properties":[{"key":"EntryName","value":"PROTEIN_KINASE_TYR"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"FFHLLLFSLGKVEAALDLILINSFPLVGNSETSLICITSKWRSRESITIDRDQEDVANQHREPLEVHEDSKRASAKTVVWKREQASETIGAYYCEGKLKDEVTRIHTMKMPLGASFHPVALTVTANKGEHVNISFIRMAAKEEDAVIYKNGSFIHSVPRHEVPGELEVSYPQVQLQDAGVYSARYIGGNLFTSAYTRLIVRRCEAQKWGPSCSSHCPFCTNNGICHEDTGECICPPGFMGKTCEKACGANTFGKTCEESCKENYGCRNYMFCLPDPYGCSCATGWMGLECDKECKPGFYGSDCKLKCNCHNRGTCDRFKGCICSHGWHGLQCEKEGSADLSPQIENLLDPVELNSGVEFKPLCIATGMPLPKSEEFKLLKQDGTVLKPALTMTSNRSEAMFTINRIQPRDTGTWVCSVQTVAGMAEKPFQVIVKVPPVPQYAPKLTDSGHNFLIIDINAELHLGDGPVVSTKLLYKPAKRYQSWMSVEVKGRTKRLDNLEPRTEYQFCVQLSRQGEGGEGHPGPQASFTTAALGLPPPEGLTLFPKSMTSLNLSWHPLTLRTEDDIRVEVERKSVNDNGDESSVITQVPGNMSTLIIKDLEPRQQYMCRVRVNARSQGEWSNYLYAWTFSDRIPPAPYNVRFSNTTDTSSVISWTTAEGHSISSIIISYKIYGKAEYNHIDIIIKNTSMTQYHLKGLEPNTVYQVQINAQNNIGLSNPNTSFELKTLPETKASYESKGGKMLLIAILGSAGMTCVTILLAFLIMLQLKRANFQRRMAQAFQNVREEPAVQFNSGTLTLSRKAKNSPDPTIYPVLEWNDIKFQDVIGEGNFGQVLKARIKKDGLRMDAAIKRMKEYASKDDHRDFAGELEVLCKLGHHPNIINLLGACEHRGYLYLAIEYAPHGNLLDFLRKSRVLETDPAFAIANSTASTLSSQQLLHFAADVARGMDYLSQKQFIHRDLAARNILVGENYVAKIADFGLSRGQEVYVKKTMGRLPVRWMAIESLNYSVYTTNSDVWSYGVLLWEIVSLGGTPYCGMTCAELYEKLPQGYRLEKPLNCDDEVYDLMRQCWREKPYERPSFAQILVSLNRMLEERKTYVNTTLYEKFTYAGIDCSAEEAA","length":1119,"molWeight":125486,"crc64":"AE3FFF2A768F7CB8","md5":"0797CF374ED02B50E1DDC4AC46A321AB"},"extraAttributes":{"countByCommentType":{"CATALYTIC ACTIVITY":1,"SUBCELLULAR LOCATION":1,"SIMILARITY":1,"CAUTION":2},"countByFeatureType":{"Transmembrane":1,"Domain":6,"Active site":1,"Binding site":1,"Disulfide bond":2,"Non-terminal residue":2},"uniParcId":"UPI00180949EB"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0A7K8L1K0","uniProtkbId":"A0A7K8L1K0_9AVES","entryAudit":{"firstPublicDate":"2021-04-07","lastAnnotationUpdateDate":"2026-11-04","lastSequenceUpdateDate":"2021-04-07","entryVersion":21,"sequenceVersion":1},"annotationScore":5.0,"organism":{"scientificName":"Ardeotis kori","taxonId":89386,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"NXE20754.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000560386"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Archelosauria","Archosauria","Dinosauria","Saurischia","Theropoda","Coelurosauria","Aves","Neognathae","Neoaves","Otidimorphae","Otidiformes","Otididae","Ardeotis"]},"proteinExistence":"3: Inferred from homology","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00070602"}],"value":"ATP-binding cassette sub-family D member 3"}},"alternativeNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00076825"}],"value":"70 kDa peroxisomal membrane protein"}}],"flag":"Fragment"},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"NXE20754.1"}],"value":"Abcd3"},"orfNames":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"NXE20754.1"}],"value":"ARDKOR_R11770"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00097293"}],"value":"ATP-dependent transporter of the ATP-binding cassette (ABC) family that catalyzes the transport of long- and very-long-chain fatty acyl-CoAs and probably bile acyl-CoAs from the cytosol to the peroxisome matrix for beta-oxydation. Appears to be specifically involved in the peroxisomal transport of branched-chain fatty acyl-CoAs (BCFA-CoAs) and dicarboxylic acyl CoAs (DCA-CoAs). Has fatty acyl-CoA thioesterase and ATPase activities. Probably hydrolyzes fatty acyl-CoAs into free fatty acids prior to their ATP-dependent transport into peroxisomes"}],"commentType":"FUNCTION"},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate(in) + ATP + H2O = (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate(out) + ADP + phosphate + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:67704"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:30616"},{"database":"ChEBI","id":"CHEBI:43474"},{"database":"ChEBI","id":"CHEBI:77016"},{"database":"ChEBI","id":"CHEBI:456216"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00097139"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:67705"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00097139"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + H2O = (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + CoA + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:67700"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:57287"},{"database":"ChEBI","id":"CHEBI:74298"},{"database":"ChEBI","id":"CHEBI:77016"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00051656"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:67701"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00051656"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate(in) + ATP + H2O = (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate(out) + ADP + phosphate + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:67708"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:30616"},{"database":"ChEBI","id":"CHEBI:43474"},{"database":"ChEBI","id":"CHEBI:58562"},{"database":"ChEBI","id":"CHEBI:456216"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00052445"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:67709"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00052445"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA + H2O = (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + CoA + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:67712"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:57287"},{"database":"ChEBI","id":"CHEBI:58562"},{"database":"ChEBI","id":"CHEBI:73862"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00051077"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:67713"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00051077"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"2,6,10,14-tetramethylpentadecanoate(in) + ATP + H2O = 2,6,10,14-tetramethylpentadecanoate(out) + ADP + phosphate + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:67688"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:30616"},{"database":"ChEBI","id":"CHEBI:43474"},{"database":"ChEBI","id":"CHEBI:77268"},{"database":"ChEBI","id":"CHEBI:456216"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00052595"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:67689"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00052595"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"3,7,11,15-tetramethylhexadecanoate(in) + ATP + H2O = 3,7,11,15-tetramethylhexadecanoate(out) + ADP + phosphate + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:86875"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:30616"},{"database":"ChEBI","id":"CHEBI:37257"},{"database":"ChEBI","id":"CHEBI:43474"},{"database":"ChEBI","id":"CHEBI:456216"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00097112"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:86876"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00097112"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"a long-chain fatty acid(in) + ATP + H2O = a long-chain fatty acid(out) + ADP + phosphate + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:67684"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:30616"},{"database":"ChEBI","id":"CHEBI:43474"},{"database":"ChEBI","id":"CHEBI:57560"},{"database":"ChEBI","id":"CHEBI:456216"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00052950"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:67685"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00052950"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"a long-chain fatty acyl-CoA + H2O = a long-chain fatty acid + CoA + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:67680"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:57287"},{"database":"ChEBI","id":"CHEBI:57560"},{"database":"ChEBI","id":"CHEBI:83139"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00051342"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:67681"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00051342"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"a very long-chain fatty acid(in) + ATP + H2O = a very long-chain fatty acid(out) + ADP + phosphate + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:67080"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:30616"},{"database":"ChEBI","id":"CHEBI:43474"},{"database":"ChEBI","id":"CHEBI:58950"},{"database":"ChEBI","id":"CHEBI:456216"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00048530"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:67081"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00048530"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"a very long-chain fatty acyl-CoA + H2O = a very long-chain fatty acid + CoA + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:67072"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:57287"},{"database":"ChEBI","id":"CHEBI:58950"},{"database":"ChEBI","id":"CHEBI:138261"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00024544"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:67073"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00024544"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"docosanoate(in) + ATP + H2O = docosanoate(out) + ADP + phosphate + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:67092"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:23858"},{"database":"ChEBI","id":"CHEBI:30616"},{"database":"ChEBI","id":"CHEBI:43474"},{"database":"ChEBI","id":"CHEBI:456216"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00097134"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:67093"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00097134"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"docosanoyl-CoA + H2O = docosanoate + CoA + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:40783"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:23858"},{"database":"ChEBI","id":"CHEBI:57287"},{"database":"ChEBI","id":"CHEBI:65059"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00097085"}]},"physiologicalReactions":[{"directionType":"right-to-left","reactionCrossReference":{"database":"Rhea","id":"RHEA:40785"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00097085"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"hexacosanoate(in) + ATP + H2O = hexacosanoate(out) + ADP + phosphate + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:67084"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:30616"},{"database":"ChEBI","id":"CHEBI:31013"},{"database":"ChEBI","id":"CHEBI:43474"},{"database":"ChEBI","id":"CHEBI:456216"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00097113"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:67085"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00097113"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"hexacosanoyl-CoA + H2O = hexacosanoate + CoA + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:40791"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:31013"},{"database":"ChEBI","id":"CHEBI:57287"},{"database":"ChEBI","id":"CHEBI:64868"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00097097"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:40792"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00097097"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"hexadecanedioate(in) + ATP + H2O = hexadecanedioate(out) + ADP + phosphate + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:67692"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:30616"},{"database":"ChEBI","id":"CHEBI:43474"},{"database":"ChEBI","id":"CHEBI:76276"},{"database":"ChEBI","id":"CHEBI:456216"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00052970"}]}},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"hexadecanedioyl-CoA + H2O = hexadecanedioate + CoA + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:67696"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:57287"},{"database":"ChEBI","id":"CHEBI:76276"},{"database":"ChEBI","id":"CHEBI:77085"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00052408"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:67697"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00052408"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"phytanoyl-CoA + H2O = 3,7,11,15-tetramethylhexadecanoate + CoA + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:40419"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:37257"},{"database":"ChEBI","id":"CHEBI:57287"},{"database":"ChEBI","id":"CHEBI:57391"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00097202"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:40420"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00097202"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"pristanoyl-CoA + H2O = 2,6,10,14-tetramethylpentadecanoate + CoA + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:40415"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:57287"},{"database":"ChEBI","id":"CHEBI:77250"},{"database":"ChEBI","id":"CHEBI:77268"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00052292"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:40416"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00052292"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"tetracosanoate(in) + ATP + H2O = tetracosanoate(out) + ADP + phosphate + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:67088"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:30616"},{"database":"ChEBI","id":"CHEBI:31014"},{"database":"ChEBI","id":"CHEBI:43474"},{"database":"ChEBI","id":"CHEBI:456216"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00097076"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:67089"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00097076"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"tetracosanoyl-CoA + H2O = tetracosanoate + CoA + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:40787"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:31014"},{"database":"ChEBI","id":"CHEBI:57287"},{"database":"ChEBI","id":"CHEBI:65052"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00097073"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:40788"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00097073"}]}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00060668"}],"value":"Lipid metabolism; branched-chain fatty acid metabolism"}],"commentType":"PATHWAY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004846"}],"value":"Lipid metabolism; peroxisomal fatty acid beta-oxidation"}],"commentType":"PATHWAY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00065720"}],"value":"Homodimers. Can form heterodimers with ABCD1 and ABCD2. Dimerization is necessary to form an active transporter. Interacts with PEX19; mediates the targeting of ABCD3 to peroxisomes"}],"commentType":"SUBUNIT"},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004585"}],"value":"Peroxisome membrane","id":"SL-0203"},"topology":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004585"}],"value":"Multi-pass membrane protein","id":"SL-9909"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00008575"}],"value":"Belongs to the ABC transporter superfamily. ABCD family. Peroxisomal fatty acyl CoA transporter (TC 3.A.1.203) subfamily"}],"commentType":"SIMILARITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"NXE20754.1"}],"value":"The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data"}],"commentType":"CAUTION"}],"features":[{"type":"Transmembrane","location":{"start":{"value":36,"modifier":"EXACT"},"end":{"value":56,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":77,"modifier":"EXACT"},"end":{"value":95,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":166,"modifier":"EXACT"},"end":{"value":196,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":259,"modifier":"EXACT"},"end":{"value":285,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Domain","location":{"start":{"value":59,"modifier":"EXACT"},"end":{"value":273,"modifier":"EXACT"}},"description":"ABC transmembrane type-1","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50929"}]},{"type":"Domain","location":{"start":{"value":385,"modifier":"EXACT"},"end":{"value":610,"modifier":"EXACT"}},"description":"ABC transporter","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50893"}]},{"type":"Binding site","location":{"start":{"value":424,"modifier":"EXACT"},"end":{"value":431,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:30616"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00434"}],"ligand":{"name":"ATP","id":"ChEBI:CHEBI:30616"}},{"type":"Non-terminal residue","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":1,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"NXE20754.1"}]},{"type":"Non-terminal residue","location":{"start":{"value":610,"modifier":"EXACT"},"end":{"value":610,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"NXE20754.1"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022990"}],"id":"KW-0007","category":"PTM","name":"Acetylation"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022840"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00434"}],"id":"KW-0067","category":"Ligand","name":"ATP-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023180"}],"id":"KW-0325","category":"PTM","name":"Glycoprotein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022801"}],"id":"KW-0378","category":"Molecular function","name":"Hydrolase"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023136"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022741"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00434"}],"id":"KW-0547","category":"Ligand","name":"Nucleotide-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023140"}],"id":"KW-0576","category":"Cellular component","name":"Peroxisome"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022553"}],"id":"KW-0597","category":"PTM","name":"Phosphoprotein"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000560386"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022967"}],"id":"KW-1278","category":"Molecular function","name":"Translocase"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022692"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022989"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-1133","category":"Domain","name":"Transmembrane helix"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022448"}],"id":"KW-0813","category":"Biological process","name":"Transport"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022843"}],"id":"KW-0832","category":"PTM","name":"Ubl conjugation"}],"references":[{"referenceNumber":1,"citation":{"id":"CI-90S2KOISV381S","citationType":"submission","authors":["Zhang G."],"title":"Bird 10,000 Genomes (B10K) Project - Family phase.","publicationDate":"SEP-2019","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"NXE20754.1"}],"value":"B10K-CU-031-01","type":"STRAIN"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"NXE20754.1"}],"value":"Muscle","type":"TISSUE"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"NXE20754.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000560386"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"VWPR01000171","properties":[{"key":"ProteinId","value":"NXE20754.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"AlphaFoldDB","id":"A0A7K8L1K0","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000560386","properties":[{"key":"Component","value":"Unassembled WGS sequence"}]},{"database":"GO","id":"GO:0005778","properties":[{"key":"GoTerm","value":"C:peroxisomal membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0140359","properties":[{"key":"GoTerm","value":"F:ABC-type transporter activity"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0005524","properties":[{"key":"GoTerm","value":"F:ATP binding"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniRule"}]},{"database":"GO","id":"GO:0016887","properties":[{"key":"GoTerm","value":"F:ATP hydrolysis activity"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0005324","properties":[{"key":"GoTerm","value":"F:long-chain fatty acid transmembrane transporter activity"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0006635","properties":[{"key":"GoTerm","value":"P:fatty acid beta-oxidation"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:0015910","properties":[{"key":"GoTerm","value":"P:long-chain fatty acid import into peroxisome"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0007031","properties":[{"key":"GoTerm","value":"P:peroxisome organization"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:0042760","properties":[{"key":"GoTerm","value":"P:very long-chain fatty acid catabolic process"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"CDD","id":"cd03223","properties":[{"key":"EntryName","value":"ABCD_peroxisomal_ALDP"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.1560.10:FF:000036","properties":[{"key":"EntryName","value":"ATP-binding cassette sub-family D member 3"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.40.50.300:FF:000636","properties":[{"key":"EntryName","value":"ATP-binding cassette sub-family D member 3"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.20.1560.10","properties":[{"key":"EntryName","value":"ABC transporter type 1, transmembrane domain"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.40.50.300","properties":[{"key":"EntryName","value":"P-loop containing nucleotide triphosphate hydrolases"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR003593","properties":[{"key":"EntryName","value":"AAA+_ATPase"}]},{"database":"InterPro","id":"IPR011527","properties":[{"key":"EntryName","value":"ABC1_TM_dom"}]},{"database":"InterPro","id":"IPR036640","properties":[{"key":"EntryName","value":"ABC1_TM_sf"}]},{"database":"InterPro","id":"IPR003439","properties":[{"key":"EntryName","value":"ABC_transporter-like_ATP-bd"}]},{"database":"InterPro","id":"IPR017871","properties":[{"key":"EntryName","value":"ABC_transporter-like_CS"}]},{"database":"InterPro","id":"IPR050835","properties":[{"key":"EntryName","value":"ABC_transporter_sub-D"}]},{"database":"InterPro","id":"IPR005283","properties":[{"key":"EntryName","value":"FA_transporter"}]},{"database":"InterPro","id":"IPR027417","properties":[{"key":"EntryName","value":"P-loop_NTPase"}]},{"database":"NCBIfam","id":"TIGR00954","properties":[{"key":"EntryName","value":"3a01203"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR11384:SF62","properties":[{"key":"EntryName","value":"ATP-BINDING CASSETTE SUB-FAMILY D MEMBER 3"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR11384","properties":[{"key":"EntryName","value":"ATP-BINDING CASSETTE, SUB-FAMILY D MEMBER"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF06472","properties":[{"key":"EntryName","value":"ABC_membrane_2"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00005","properties":[{"key":"EntryName","value":"ABC_tran"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00382","properties":[{"key":"EntryName","value":"AAA"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF90123","properties":[{"key":"EntryName","value":"ABC transporter transmembrane region"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF52540","properties":[{"key":"EntryName","value":"P-loop containing nucleoside triphosphate hydrolases"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50929","properties":[{"key":"EntryName","value":"ABC_TM1F"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00211","properties":[{"key":"EntryName","value":"ABC_TRANSPORTER_1"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50893","properties":[{"key":"EntryName","value":"ABC_TRANSPORTER_2"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"QKEGKKERAMVDRVFIARICRILKIMVPRTLCKETGYLLLIAVMLVVRTYCDIWMIQNGTVIESAIIGRSRKDFKKYLFNFIAAMPAISLVNNFLKYGLNELKLCFRVRLTRYLYEEYLKSYTYYKMGNLDNRIANPDQLLTQDVEKFCNSVVDLYSNLSKPFLDIVLYIFKLTSAIGAQGPASMMAYLIISGFFLTRLRRPIGKMTIIEQKYEGEYRYVNSRLITNSEEIAFYNGNLREKQTIHKTFRKLVEHLHNFILFRFSMGFIDTIIAKYLATVVGYLVVSRPFLNLADPRHQNSTHAELLEDYYQSGRMLLRMSQALGRIVLAGREMTRLAGFTARITELMQVLKDLNSGKYQRTMVSQEKDADKKQALPLIPGSGEIINTDNLIKFDHVPLVTPNGDVLIQDLNFEVRSGANVLICGPNGCGKSSLFRVLGELWPLFGGRLTKPVRGKLFYVPQRPYMTLGTLRDQVIYPDTLEDQRKKGISDQVLKEYLDNVQLGQILEREGGWDSVQDWMDVLSGGEKQRMAMARLFYHKPQFAILDECTSAVSVDVEGYIYSHCRKVGITLFTVSHRKSLWKHHDFYLHMDGRGNYEFKKITEDTVEFGS","length":610,"molWeight":70295,"crc64":"EEA5A2D884E4367A","md5":"3F1EB843D022F9C6C2E0D6E9ED21A89D"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"CATALYTIC ACTIVITY":20,"PATHWAY":2,"SUBUNIT":1,"SUBCELLULAR LOCATION":1,"SIMILARITY":1,"CAUTION":1},"countByFeatureType":{"Transmembrane":4,"Domain":2,"Binding site":1,"Non-terminal residue":2},"uniParcId":"UPI0017936403"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0A7K8L200","uniProtkbId":"A0A7K8L200_9AVES","entryAudit":{"firstPublicDate":"2021-04-07","lastAnnotationUpdateDate":"2026-11-04","lastSequenceUpdateDate":"2021-04-07","entryVersion":20,"sequenceVersion":1},"annotationScore":5.0,"organism":{"scientificName":"Ardeotis kori","taxonId":89386,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"NXE20894.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000560386"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Archelosauria","Archosauria","Dinosauria","Saurischia","Theropoda","Coelurosauria","Aves","Neognathae","Neoaves","Otidimorphae","Otidiformes","Otididae","Ardeotis"]},"proteinExistence":"3: Inferred from homology","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00040963"}],"value":"11-beta-hydroxysteroid dehydrogenase 1"},"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00038971"}],"value":"1.1.1.146"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00039048"}],"value":"1.1.1.201"}]},"alternativeNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00041676"}],"value":"7-oxosteroid reductase"}},{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00041539"}],"value":"Corticosteroid 11-beta-dehydrogenase isozyme 1"}}],"flag":"Fragment"},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"NXE20894.1"}],"value":"Hsd11b1_0"},"orfNames":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"NXE20894.1"}],"value":"ARDKOR_R01514"}]}],"comments":[{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"11beta,17beta-dihydroxyandrost-4-ene-3-one + NADP(+) = 17beta-hydroxyandrost-4-ene-3,11-dione + NADPH + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:86451"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:34133"},{"database":"ChEBI","id":"CHEBI:57783"},{"database":"ChEBI","id":"CHEBI:58349"},{"database":"ChEBI","id":"CHEBI:81481"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00095462"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:86452"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00095462"}]},{"directionType":"right-to-left","reactionCrossReference":{"database":"Rhea","id":"RHEA:86453"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00095462"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"11beta-hydroxyandrost-4-ene-3,17-dione + NADP(+) = androst-4-ene-3,11,17-trione + NADPH + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:86411"},{"database":"ChEBI","id":"CHEBI:2495"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:27967"},{"database":"ChEBI","id":"CHEBI:57783"},{"database":"ChEBI","id":"CHEBI:58349"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00095599"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:86412"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00095599"}]},{"directionType":"right-to-left","reactionCrossReference":{"database":"Rhea","id":"RHEA:86413"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00095599"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"3beta,7alpha-dihydroxyandrost-5-en-17-one + NADP(+) = 3beta-hydroxy-5-androstene-7,17-dione + NADPH + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:69440"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:57783"},{"database":"ChEBI","id":"CHEBI:58349"},{"database":"ChEBI","id":"CHEBI:81471"},{"database":"ChEBI","id":"CHEBI:183808"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00048678"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:69441"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00048678"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"3beta-hydroxy-5-androstene-7,17-dione + NADPH + H(+) = 3beta,7beta-dihydroxyandrost-5-en-17-one + NADP(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:69452"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:57783"},{"database":"ChEBI","id":"CHEBI:58349"},{"database":"ChEBI","id":"CHEBI:183368"},{"database":"ChEBI","id":"CHEBI:183808"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00047608"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:69453"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00047608"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"3beta-hydroxy-5alpha-androstane-7,17-dione + NADPH + H(+) = 3beta,7beta-dihydroxy-5alpha-androstan-17-one + NADP(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:69456"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:57783"},{"database":"ChEBI","id":"CHEBI:58349"},{"database":"ChEBI","id":"CHEBI:79834"},{"database":"ChEBI","id":"CHEBI:183809"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00047373"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:69457"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00047373"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"7-oxocholesterol + NADPH + H(+) = 7beta-hydroxycholesterol + NADP(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:68656"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:42989"},{"database":"ChEBI","id":"CHEBI:57783"},{"database":"ChEBI","id":"CHEBI:58349"},{"database":"ChEBI","id":"CHEBI:64294"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00048585"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:68657"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00048585"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"7-oxolithocholate + NADPH + H(+) = ursodeoxycholate + NADP(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:47540"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:57783"},{"database":"ChEBI","id":"CHEBI:58349"},{"database":"ChEBI","id":"CHEBI:78604"},{"database":"ChEBI","id":"CHEBI:78605"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00049462"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:47541"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00049462"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"7-oxopregnenolone + NADPH + H(+) = 7beta-hydroxypregnenolone + NADP(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:69436"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:57783"},{"database":"ChEBI","id":"CHEBI:58349"},{"database":"ChEBI","id":"CHEBI:183806"},{"database":"ChEBI","id":"CHEBI:183807"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00049520"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:69437"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00049520"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"a 7beta-hydroxysteroid + NADP(+) = a 7-oxosteroid + NADPH + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:20233"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:35349"},{"database":"ChEBI","id":"CHEBI:47789"},{"database":"ChEBI","id":"CHEBI:57783"},{"database":"ChEBI","id":"CHEBI:58349"}],"ecNumber":"1.1.1.201","evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00049300"}]},"physiologicalReactions":[{"directionType":"right-to-left","reactionCrossReference":{"database":"Rhea","id":"RHEA:20235"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00049300"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"an 11beta-hydroxysteroid + NADP(+) = an 11-oxosteroid + NADPH + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:11388"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:35346"},{"database":"ChEBI","id":"CHEBI:47787"},{"database":"ChEBI","id":"CHEBI:57783"},{"database":"ChEBI","id":"CHEBI:58349"}],"ecNumber":"1.1.1.146","evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00048376"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:11389"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00048376"}]},{"directionType":"right-to-left","reactionCrossReference":{"database":"Rhea","id":"RHEA:11390"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00048376"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"chenodeoxycholate + NADP(+) = 7-oxolithocholate + NADPH + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:53820"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:36234"},{"database":"ChEBI","id":"CHEBI:57783"},{"database":"ChEBI","id":"CHEBI:58349"},{"database":"ChEBI","id":"CHEBI:78605"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00047269"}]},"physiologicalReactions":[{"directionType":"right-to-left","reactionCrossReference":{"database":"Rhea","id":"RHEA:53822"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00047269"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"corticosterone + NADP(+) = 11-dehydrocorticosterone + NADPH + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:42200"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:16827"},{"database":"ChEBI","id":"CHEBI:57783"},{"database":"ChEBI","id":"CHEBI:58349"},{"database":"ChEBI","id":"CHEBI:78600"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00047749"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:42201"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00047749"}]},{"directionType":"right-to-left","reactionCrossReference":{"database":"Rhea","id":"RHEA:42202"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00047749"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"glycochenodeoxycholate + NADP(+) = 7-oxoglycolithocholate + NADPH + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:65056"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:36252"},{"database":"ChEBI","id":"CHEBI:57783"},{"database":"ChEBI","id":"CHEBI:58349"},{"database":"ChEBI","id":"CHEBI:137818"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00048661"}]},"physiologicalReactions":[{"directionType":"right-to-left","reactionCrossReference":{"database":"Rhea","id":"RHEA:65058"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00048661"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"glycoursodeoxycholate + NADP(+) = 7-oxoglycolithocholate + NADPH + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:68976"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:57783"},{"database":"ChEBI","id":"CHEBI:58349"},{"database":"ChEBI","id":"CHEBI:132030"},{"database":"ChEBI","id":"CHEBI:137818"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00048060"}]},"physiologicalReactions":[{"directionType":"right-to-left","reactionCrossReference":{"database":"Rhea","id":"RHEA:68978"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00048060"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"taurochenodeoxycholate + NADP(+) = 7-oxotaurolithocholate + NADPH + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:65060"},{"database":"ChEBI","id":"CHEBI:9407"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:57783"},{"database":"ChEBI","id":"CHEBI:58349"},{"database":"ChEBI","id":"CHEBI:137724"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00048061"}]},"physiologicalReactions":[{"directionType":"right-to-left","reactionCrossReference":{"database":"Rhea","id":"RHEA:65062"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00048061"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"tauroursodeoxycholate + NADP(+) = 7-oxotaurolithocholate + NADPH + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:68980"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:57783"},{"database":"ChEBI","id":"CHEBI:58349"},{"database":"ChEBI","id":"CHEBI:132028"},{"database":"ChEBI","id":"CHEBI:137724"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00048702"}]},"physiologicalReactions":[{"directionType":"right-to-left","reactionCrossReference":{"database":"Rhea","id":"RHEA:68982"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00048702"}]}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00011738"}],"value":"Homodimer"}],"commentType":"SUBUNIT"},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004648"}],"value":"Endoplasmic reticulum membrane","id":"SL-0097"},"topology":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004648"}],"value":"Single-pass type II membrane protein","id":"SL-9906"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00006484"}],"value":"Belongs to the short-chain dehydrogenases/reductases (SDR) family"}],"commentType":"SIMILARITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"NXE20894.1"}],"value":"The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data"}],"commentType":"CAUTION"}],"features":[{"type":"Active site","location":{"start":{"value":183,"modifier":"EXACT"},"end":{"value":183,"modifier":"EXACT"}},"description":"Proton acceptor","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU10001"}]},{"type":"Non-terminal residue","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":1,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"NXE20894.1"}]},{"type":"Non-terminal residue","location":{"start":{"value":292,"modifier":"EXACT"},"end":{"value":292,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"NXE20894.1"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022824"}],"id":"KW-0256","category":"Cellular component","name":"Endoplasmic reticulum"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023136"}],"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023002"}],"id":"KW-0560","category":"Molecular function","name":"Oxidoreductase"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000560386"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022692"}],"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022989"}],"id":"KW-1133","category":"Domain","name":"Transmembrane helix"}],"references":[{"referenceNumber":1,"citation":{"id":"CI-90S2KOISV381S","citationType":"submission","authors":["Zhang G."],"title":"Bird 10,000 Genomes (B10K) Project - Family phase.","publicationDate":"SEP-2019","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"NXE20894.1"}],"value":"B10K-CU-031-01","type":"STRAIN"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"NXE20894.1"}],"value":"Muscle","type":"TISSUE"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"NXE20894.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000560386"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"VWPR01000181","properties":[{"key":"ProteinId","value":"NXE20894.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"AlphaFoldDB","id":"A0A7K8L200","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000560386","properties":[{"key":"Component","value":"Unassembled WGS sequence"}]},{"database":"GO","id":"GO:0005789","properties":[{"key":"GoTerm","value":"C:endoplasmic reticulum membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0070524","properties":[{"key":"GoTerm","value":"F:11-beta-hydroxysteroid dehydrogenase (NADP+) activity"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-EC"}]},{"database":"GO","id":"GO:0047022","properties":[{"key":"GoTerm","value":"F:7-beta-hydroxysteroid dehydrogenase (NADP+) activity"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-EC"}]},{"database":"GO","id":"GO:0005496","properties":[{"key":"GoTerm","value":"F:steroid binding"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:0006706","properties":[{"key":"GoTerm","value":"P:steroid catabolic process"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"CDD","id":"cd05332","properties":[{"key":"EntryName","value":"11beta-HSD1_like_SDR_c"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.40.50.720:FF:000329","properties":[{"key":"EntryName","value":"Corticosteroid 11-beta-dehydrogenase isozyme 1"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.40.50.720","properties":[{"key":"EntryName","value":"NAD(P)-binding Rossmann-like Domain"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR051253","properties":[{"key":"EntryName","value":"11-beta-HSD"}]},{"database":"InterPro","id":"IPR036291","properties":[{"key":"EntryName","value":"NAD(P)-bd_dom_sf"}]},{"database":"InterPro","id":"IPR020904","properties":[{"key":"EntryName","value":"Sc_DH/Rdtase_CS"}]},{"database":"InterPro","id":"IPR002347","properties":[{"key":"EntryName","value":"SDR_fam"}]},{"database":"PANTHER","id":"PTHR44279:SF1","properties":[{"key":"EntryName","value":"11-BETA-HYDROXYSTEROID DEHYDROGENASE 1"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR44279","properties":[{"key":"EntryName","value":"HYDROXYSTEROID (11-BETA) DEHYDROGENASE 1-LIKE B-RELATED"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00106","properties":[{"key":"EntryName","value":"adh_short"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR00081","properties":[{"key":"EntryName","value":"GDHRDH"}]},{"database":"SUPFAM","id":"SSF51735","properties":[{"key":"EntryName","value":"NAD(P)-binding Rossmann-fold domains"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00061","properties":[{"key":"EntryName","value":"ADH_SHORT"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MGLLLKIFIPLLGLALAFYFYSAPENFNEEMLRGKRVIVTGASSGIGEQMAYHLARMEAHLLLTARTEAKLQKVVERCLELGAASARYVSGSMEDTTFPTVVVKEAEITWGGLDMLILNHIGFSHFNYFNGDVEHVRKLLETNFLSYVAMTVSALPMLKESEGSIVVVSSMAGKTAGPFTAPYSATKFALDGFFSSLRHEFIIDKVNVSITLCILGYINTDSAVRAVSHVIQVTPAPKEECALEIIKSGALRRRELHYPSWHVGSLLLLRDIAPDFLDSLVRSSYKVENIKR","length":292,"molWeight":32337,"crc64":"6274F52C9EB50986","md5":"9F77E6E177B2B38BCBF306FC80736278"},"extraAttributes":{"countByCommentType":{"CATALYTIC ACTIVITY":16,"SUBUNIT":1,"SUBCELLULAR LOCATION":1,"SIMILARITY":1,"CAUTION":1},"countByFeatureType":{"Active site":1,"Non-terminal residue":2},"uniParcId":"UPI00182BAC43"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0A7K8L2I6","uniProtkbId":"A0A7K8L2I6_9AVES","entryAudit":{"firstPublicDate":"2021-04-07","lastAnnotationUpdateDate":"2026-11-04","lastSequenceUpdateDate":"2021-04-07","entryVersion":19,"sequenceVersion":1},"annotationScore":5.0,"organism":{"scientificName":"Ardeotis kori","taxonId":89386,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"NXE23547.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000560386"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Archelosauria","Archosauria","Dinosauria","Saurischia","Theropoda","Coelurosauria","Aves","Neognathae","Neoaves","Otidimorphae","Otidiformes","Otididae","Ardeotis"]},"proteinExistence":"3: Inferred from homology","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00013254"}],"value":"acylglycerol lipase"},"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00013254"}],"value":"3.1.1.23"}]},"flag":"Fragment"},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"NXE23547.1"}],"value":"Abhd6"},"orfNames":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"NXE23547.1"}],"value":"ARDKOR_R09068"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00049568"}],"value":"Lipase that preferentially hydrolysis medium-chain saturated monoacylglycerols including 2-arachidonoylglycerol. Through 2-arachidonoylglycerol degradation may regulate endocannabinoid signaling pathways. Also has a lysophosphatidyl lipase activity with a preference for lysophosphatidylglycerol among other lysophospholipids. Also able to degrade bis(monoacylglycero)phosphate (BMP) and constitutes the major enzyme for BMP catabolism. BMP, also known as lysobisphosphatidic acid, is enriched in late endosomes and lysosomes and plays a key role in the formation of intraluminal vesicles and in lipid sorting"}],"commentType":"FUNCTION"},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"(R,R)-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(2'-(9Z-octadecenoyl)-3'-sn-glycerol) + H2O = (R,R)-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(3'-sn-glycerol) + (9Z)-octadecenoate + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:55804"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:30823"},{"database":"ChEBI","id":"CHEBI:139228"},{"database":"ChEBI","id":"CHEBI:139230"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00095454"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:55805"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00095454"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"(S,S)-2-(9Z-octadecenoyl)-sn-glycero-1-phospho-(2'-(9Z-octadecenoyl)-1'-sn-glycerol) + H2O = (S,S)-2-(9Z-octadecenoyl)-sn-glycero-1-phospho-(1'-sn-glycerol) + (9Z)-octadecenoate + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:55716"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:30823"},{"database":"ChEBI","id":"CHEBI:139156"},{"database":"ChEBI","id":"CHEBI:139157"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00095773"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:55717"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00095773"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + H2O = glycerol + (5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:44728"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:17754"},{"database":"ChEBI","id":"CHEBI:32395"},{"database":"ChEBI","id":"CHEBI:75612"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00095749"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:44729"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00095749"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"1-(9Z,12Z-octadecadienoyl)-glycerol + H2O = (9Z,12Z)-octadecadienoate + glycerol + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:48428"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:17754"},{"database":"ChEBI","id":"CHEBI:30245"},{"database":"ChEBI","id":"CHEBI:75568"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00095439"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:48429"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00095439"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"1-(9Z-octadecenoyl)-glycerol + H2O = glycerol + (9Z)-octadecenoate + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:38487"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:17754"},{"database":"ChEBI","id":"CHEBI:30823"},{"database":"ChEBI","id":"CHEBI:75342"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00047438"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:38488"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00047438"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"1-decanoylglycerol + H2O = decanoate + glycerol + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:44320"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:17754"},{"database":"ChEBI","id":"CHEBI:27689"},{"database":"ChEBI","id":"CHEBI:75547"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00095656"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:44321"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00095656"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"1-octanoylglycerol + H2O = octanoate + glycerol + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:44328"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:17754"},{"database":"ChEBI","id":"CHEBI:25646"},{"database":"ChEBI","id":"CHEBI:85241"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00095577"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:44329"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00095577"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"1-tetradecanoylglycerol + H2O = tetradecanoate + glycerol + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:44312"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:17754"},{"database":"ChEBI","id":"CHEBI:30807"},{"database":"ChEBI","id":"CHEBI:75562"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00095793"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:44313"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00095793"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + H2O = glycerol + (5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:26132"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:17754"},{"database":"ChEBI","id":"CHEBI:32395"},{"database":"ChEBI","id":"CHEBI:52392"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00047476"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:26133"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00047476"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"2-(9Z,12Z-octadecadienoyl)-glycerol + H2O = (9Z,12Z)-octadecadienoate + glycerol + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:44732"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:17754"},{"database":"ChEBI","id":"CHEBI:30245"},{"database":"ChEBI","id":"CHEBI:75457"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00095597"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:44733"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00095597"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"2-(9Z-octadecenoyl)-glycerol + H2O = glycerol + (9Z)-octadecenoate + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:38491"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:17754"},{"database":"ChEBI","id":"CHEBI:30823"},{"database":"ChEBI","id":"CHEBI:73990"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00049461"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:38492"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00049461"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"2-hexadecanoylglycerol + H2O = glycerol + hexadecanoate + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:39963"},{"database":"ChEBI","id":"CHEBI:7896"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:17754"},{"database":"ChEBI","id":"CHEBI:75455"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00095761"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:39964"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00095761"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"3-(9Z-octadecenoyl)-sn-glycero-1-phospho-(3'-(9Z-octadecenoyl)-1'-sn-glycerol) + H2O = 3-(9Z-octadecenoyl)-sn-glycero-1-phospho-(1'-sn-glycerol) + (9Z)-octadecenoate + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:55712"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:30823"},{"database":"ChEBI","id":"CHEBI:139150"},{"database":"ChEBI","id":"CHEBI:139152"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00095721"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:55713"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00095721"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"Hydrolyzes glycerol monoesters of long-chain fatty acids.","ecNumber":"3.1.1.23","evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00001613"}]}},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"a 1-acylglycerol + H2O = glycerol + a fatty acid + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:34019"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:17754"},{"database":"ChEBI","id":"CHEBI:28868"},{"database":"ChEBI","id":"CHEBI:35759"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00050205"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:34020"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00050205"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"a 2-acylglycerol + H2O = glycerol + a fatty acid + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:44688"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:17389"},{"database":"ChEBI","id":"CHEBI:17754"},{"database":"ChEBI","id":"CHEBI:28868"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00051776"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:44689"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00051776"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"a 3-acyl-sn-glycero-1-phospho-(3'-acyl-1'-sn-glycerol) + H2O = a 3-acyl-sn-glycero-1-phospho-(1'-sn-glycerol) + a fatty acid + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:85303"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:28868"},{"database":"ChEBI","id":"CHEBI:77717"},{"database":"ChEBI","id":"CHEBI:197425"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00095625"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:85304"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00095625"}]}]},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00037797"}],"value":"Late endosome membrane","id":"SL-0151"},"topology":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00037797"}],"value":"Single-pass type II membrane protein","id":"SL-9906"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00037874"}],"value":"Lysosome membrane","id":"SL-0157"},"topology":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00037874"}],"value":"Single-pass type II membrane protein","id":"SL-9906"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00046308"}],"value":"Mitochondrion membrane","id":"SL-0171"},"topology":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00046308"}],"value":"Single-pass type II membrane protein","id":"SL-9906"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00008645"}],"value":"Belongs to the AB hydrolase superfamily"}],"commentType":"SIMILARITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"NXE23547.1"}],"value":"The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data"}],"commentType":"CAUTION"}],"features":[{"type":"Domain","location":{"start":{"value":72,"modifier":"EXACT"},"end":{"value":313,"modifier":"EXACT"}},"description":"AB hydrolase-1","evidences":[{"evidenceCode":"ECO:0000259","source":"Pfam","id":"PF00561"}]},{"type":"Non-terminal residue","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":1,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"NXE23547.1"}]},{"type":"Non-terminal residue","location":{"start":{"value":337,"modifier":"EXACT"},"end":{"value":337,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"NXE23547.1"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022753"}],"id":"KW-0967","category":"Cellular component","name":"Endosome"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022801"}],"id":"KW-0378","category":"Molecular function","name":"Hydrolase"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023098"}],"id":"KW-0443","category":"Biological process","name":"Lipid metabolism"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023228"}],"id":"KW-0458","category":"Cellular component","name":"Lysosome"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023136"}],"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023128"}],"id":"KW-0496","category":"Cellular component","name":"Mitochondrion"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000560386"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022968"}],"id":"KW-0735","category":"Domain","name":"Signal-anchor"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022692"}],"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022989"}],"id":"KW-1133","category":"Domain","name":"Transmembrane helix"}],"references":[{"referenceNumber":1,"citation":{"id":"CI-90S2KOISV381S","citationType":"submission","authors":["Zhang G."],"title":"Bird 10,000 Genomes (B10K) Project - Family phase.","publicationDate":"SEP-2019","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"NXE23547.1"}],"value":"B10K-CU-031-01","type":"STRAIN"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"NXE23547.1"}],"value":"Muscle","type":"TISSUE"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"NXE23547.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000560386"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"VWPR01000506","properties":[{"key":"ProteinId","value":"NXE23547.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"AlphaFoldDB","id":"A0A7K8L2I6","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000560386","properties":[{"key":"Component","value":"Unassembled WGS sequence"}]},{"database":"GO","id":"GO:0032281","properties":[{"key":"GoTerm","value":"C:AMPA glutamate receptor complex"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:0031902","properties":[{"key":"GoTerm","value":"C:late endosome membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0005765","properties":[{"key":"GoTerm","value":"C:lysosomal membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0031966","properties":[{"key":"GoTerm","value":"C:mitochondrial membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0047372","properties":[{"key":"GoTerm","value":"F:monoacylglycerol lipase activity"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-EC"}]},{"database":"GO","id":"GO:0046464","properties":[{"key":"GoTerm","value":"P:acylglycerol catabolic process"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"FunFam","id":"3.40.50.1820:FF:000082","properties":[{"key":"EntryName","value":"monoacylglycerol lipase ABHD6"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.40.50.1820","properties":[{"key":"EntryName","value":"alpha/beta hydrolase"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR000073","properties":[{"key":"EntryName","value":"AB_hydrolase_1"}]},{"database":"InterPro","id":"IPR029058","properties":[{"key":"EntryName","value":"AB_hydrolase_fold"}]},{"database":"InterPro","id":"IPR050266","properties":[{"key":"EntryName","value":"AB_hydrolase_sf"}]},{"database":"PANTHER","id":"PTHR43798","properties":[{"key":"EntryName","value":"MONOACYLGLYCEROL LIPASE"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR43798:SF5","properties":[{"key":"EntryName","value":"MONOACYLGLYCEROL LIPASE ABHD6"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00561","properties":[{"key":"EntryName","value":"Abhydrolase_1"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR00111","properties":[{"key":"EntryName","value":"ABHYDROLASE"}]},{"database":"SUPFAM","id":"SSF53474","properties":[{"key":"EntryName","value":"alpha/beta-Hydrolases"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MDMDVLNMFVIAGGTLAIPILAFVASFLLWPSALIRIYYWYWRRALGMQVRYANYDDYQFCYSYRGRPGYRPSILMLHGFSAHKDMWLSIVKFLPKNLHLVCVDMPGHEGTTRSVLDDYSISGQAERIHQFVECIRLNRRPFHLVGTSMGGNVAGVYAAQYPEDICSLTLICPAGLPSTTESKFIKQLREMQESERIDRIPLIPSTPEEMADMLKLCSYVRFKVPQQILQGLVDVRIPHNDFYRKLFLEIVNEKSRHSLHENMSKIKAPTQVIWGKQDQVLDVSGASVLASAIPDCHVYILENCGHSVVVERPRKTANLILEFLALLHSMGNNKKQA","length":337,"molWeight":38453,"crc64":"3471DD92227CE383","md5":"DC218B19089710B703A659BFEFEE9139"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"CATALYTIC ACTIVITY":17,"SUBCELLULAR LOCATION":1,"SIMILARITY":1,"CAUTION":1},"countByFeatureType":{"Domain":1,"Non-terminal residue":2},"uniParcId":"UPI001848B888"}}]}