{"results":[{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0A097PJS2","uniProtkbId":"A0A097PJS2_9LILI","entryAudit":{"firstPublicDate":"2015-01-07","lastAnnotationUpdateDate":"2026-11-04","lastSequenceUpdateDate":"2015-01-07","entryVersion":46,"sequenceVersion":1},"annotationScore":3.0,"organism":{"scientificName":"Lilium brownii","commonName":"Hong Kong lily","taxonId":82312,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AIU48267.1"}],"lineage":["Eukaryota","Viridiplantae","Streptophyta","Embryophyta","Tracheophyta","Spermatophyta","Magnoliopsida","Liliopsida","Liliales","Liliaceae","Lilium"]},"proteinExistence":"2: Evidence at transcript level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU368063"}],"value":"DNA replication licensing factor MCM5"},"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU368063"}],"value":"3.6.4.12"}]},"flag":"Fragment"},"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU368063"}],"value":"Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity"}],"commentType":"FUNCTION"},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"ATP + H2O = ADP + phosphate + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:13065"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:30616"},{"database":"ChEBI","id":"CHEBI:43474"},{"database":"ChEBI","id":"CHEBI:456216"}],"ecNumber":"3.6.4.12","evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU368063"}]}},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU368063"}],"value":"Component of the MCM2-7 complex"}],"commentType":"SUBUNIT"},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU368063"}],"value":"Nucleus","id":"SL-0191"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00008010"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU01410"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU004070"}],"value":"Belongs to the MCM family"}],"commentType":"SIMILARITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU01410"}],"value":"Lacks conserved residue(s) required for the propagation of feature annotation"}],"commentType":"CAUTION"}],"features":[{"type":"Domain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":191,"modifier":"EXACT"}},"description":"MCM C-terminal AAA(+) ATPase","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50051"}]},{"type":"Site","location":{"start":{"value":50,"modifier":"EXACT"},"end":{"value":50,"modifier":"EXACT"}},"description":"Arginine finger","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU01410"}]},{"type":"Non-terminal residue","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":1,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AIU48267.1"}]},{"type":"Non-terminal residue","location":{"start":{"value":223,"modifier":"EXACT"},"end":{"value":223,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AIU48267.1"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU01410"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU004070"}],"id":"KW-0067","category":"Ligand","name":"ATP-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023306"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU01410"}],"id":"KW-0131","category":"Biological process","name":"Cell cycle"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU01410"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU368063"}],"id":"KW-0235","category":"Biological process","name":"DNA replication"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU01410"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU004070"}],"id":"KW-0238","category":"Molecular function","name":"DNA-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU368063"}],"id":"KW-0347","category":"Molecular function","name":"Helicase"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU368063"}],"id":"KW-0378","category":"Molecular function","name":"Hydrolase"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU01410"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU004070"}],"id":"KW-0547","category":"Ligand","name":"Nucleotide-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU01410"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU368063"}],"id":"KW-0539","category":"Cellular component","name":"Nucleus"}],"references":[{"referenceNumber":1,"citation":{"id":"25249442","citationType":"journal article","authors":["Zeng L.","Zhang Q.","Sun R.","Kong H.","Zhang N.","Ma H."],"citationCrossReferences":[{"database":"PubMed","id":"25249442"},{"database":"DOI","id":"10.1038/ncomms5956"}],"title":"Resolution of deep angiosperm phylogeny using conserved nuclear genes and estimates of early divergence times.","publicationDate":"2014","journal":"Nat. Commun.","firstPage":"4956","lastPage":"4956","volume":"5"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AIU48267.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"KM397601","properties":[{"key":"ProteinId","value":"AIU48267.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"AlphaFoldDB","id":"A0A097PJS2","properties":[{"key":"Description","value":"-"}]},{"database":"GO","id":"GO:0042555","properties":[{"key":"GoTerm","value":"C:MCM complex"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniRule"}]},{"database":"GO","id":"GO:0005634","properties":[{"key":"GoTerm","value":"C:nucleus"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0043138","properties":[{"key":"GoTerm","value":"F:3'-5' DNA helicase activity"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:0005524","properties":[{"key":"GoTerm","value":"F:ATP binding"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniRule"}]},{"database":"GO","id":"GO:0003688","properties":[{"key":"GoTerm","value":"F:DNA replication origin binding"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniRule"}]},{"database":"GO","id":"GO:0003697","properties":[{"key":"GoTerm","value":"F:single-stranded DNA binding"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:0017116","properties":[{"key":"GoTerm","value":"F:single-stranded DNA helicase activity"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:0006270","properties":[{"key":"GoTerm","value":"P:DNA replication initiation"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniRule"}]},{"database":"GO","id":"GO:0000727","properties":[{"key":"GoTerm","value":"P:double-strand break repair via break-induced replication"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"Gene3D","id":"3.40.50.300","properties":[{"key":"EntryName","value":"P-loop containing nucleotide triphosphate hydrolases"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR031327","properties":[{"key":"EntryName","value":"MCM"}]},{"database":"InterPro","id":"IPR008048","properties":[{"key":"EntryName","value":"MCM5"}]},{"database":"InterPro","id":"IPR001208","properties":[{"key":"EntryName","value":"MCM_dom"}]},{"database":"InterPro","id":"IPR041562","properties":[{"key":"EntryName","value":"MCM_lid"}]},{"database":"InterPro","id":"IPR027417","properties":[{"key":"EntryName","value":"P-loop_NTPase"}]},{"database":"PANTHER","id":"PTHR11630","properties":[{"key":"EntryName","value":"DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR11630:SF42","properties":[{"key":"EntryName","value":"DNA REPLICATION LICENSING FACTOR MCM5"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00493","properties":[{"key":"EntryName","value":"MCM"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF17855","properties":[{"key":"EntryName","value":"MCM_lid"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR01657","properties":[{"key":"EntryName","value":"MCMFAMILY"}]},{"database":"PRINTS","id":"PR01661","properties":[{"key":"EntryName","value":"MCMPROTEIN5"}]},{"database":"SMART","id":"SM00350","properties":[{"key":"EntryName","value":"MCM"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF52540","properties":[{"key":"EntryName","value":"P-loop containing nucleoside triphosphate hydrolases"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50051","properties":[{"key":"EntryName","value":"MCM_CTD"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"QTISIAKAGITTVLNSRTSVLAAANPPSGRYDDLKTAQDNIDLQTTILSRFDLIFIVKDIRQYAQDQRIASHIIKVHASGATNSKTNEAGEGENWLKRYIEYCRAYCQPRLSEQASEMLKLKYVEIRQKMRQQAHETGKASAIPITVRQLEAIIRLSESLAKMRLSSIATEEHVKEAFNLFDVSTMDAARSGINEHLNLTPEIANEIKQAETQIKRRMGIGSH","length":223,"molWeight":25025,"crc64":"6C0C237D8276D78C","md5":"D72FA6A4A47A1485BC8652BA69AF2C17"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"CATALYTIC ACTIVITY":1,"SUBUNIT":1,"SUBCELLULAR LOCATION":1,"SIMILARITY":1,"CAUTION":1},"countByFeatureType":{"Domain":1,"Site":1,"Non-terminal residue":2},"uniParcId":"UPI00052A53A8"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0A097PPC0","uniProtkbId":"A0A097PPC0_9LILI","entryAudit":{"firstPublicDate":"2015-01-07","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2015-01-07","entryVersion":42,"sequenceVersion":1},"annotationScore":3.0,"organism":{"scientificName":"Lilium brownii","commonName":"Hong Kong lily","taxonId":82312,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AIU49879.1"}],"lineage":["Eukaryota","Viridiplantae","Streptophyta","Embryophyta","Tracheophyta","Spermatophyta","Magnoliopsida","Liliopsida","Liliales","Liliaceae","Lilium"]},"proteinExistence":"2: Evidence at transcript level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00012376"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU291113"}],"value":"tRNA-dihydrouridine(47) synthase [NAD(P)(+)]"},"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU291113"}],"value":"1.3.1.-"}]},"alternativeNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU291113"}],"value":"tRNA-dihydrouridine synthase 3"}}],"flag":"Fragment"},"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00045934"}],"value":"Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs. Specifically modifies U47 in cytoplasmic tRNAs. Catalyzes the synthesis of dihydrouridine in some mRNAs, thereby affecting their translation"}],"commentType":"FUNCTION"},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"5,6-dihydrouridine(47) in tRNA + NAD(+) = uridine(47) in tRNA + NADH + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:53364"},{"database":"Rhea","id":"RHEA-COMP:13539"},{"database":"Rhea","id":"RHEA-COMP:13540"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:57540"},{"database":"ChEBI","id":"CHEBI:57945"},{"database":"ChEBI","id":"CHEBI:65315"},{"database":"ChEBI","id":"CHEBI:74443"}],"ecNumber":"1.3.1.89","evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00048266"}]},"physiologicalReactions":[{"directionType":"right-to-left","reactionCrossReference":{"database":"Rhea","id":"RHEA:53366"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00048266"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"5,6-dihydrouridine(47) in tRNA + NADP(+) = uridine(47) in tRNA + NADPH + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:53360"},{"database":"Rhea","id":"RHEA-COMP:13539"},{"database":"Rhea","id":"RHEA-COMP:13540"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:57783"},{"database":"ChEBI","id":"CHEBI:58349"},{"database":"ChEBI","id":"CHEBI:65315"},{"database":"ChEBI","id":"CHEBI:74443"}],"ecNumber":"1.3.1.89","evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00049513"}]},"physiologicalReactions":[{"directionType":"right-to-left","reactionCrossReference":{"database":"Rhea","id":"RHEA:53362"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00049513"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"a 5,6-dihydrouridine in mRNA + NAD(+) = a uridine in mRNA + NADH + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:69851"},{"database":"Rhea","id":"RHEA-COMP:14658"},{"database":"Rhea","id":"RHEA-COMP:17789"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:57540"},{"database":"ChEBI","id":"CHEBI:57945"},{"database":"ChEBI","id":"CHEBI:65315"},{"database":"ChEBI","id":"CHEBI:74443"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00048342"}]},"physiologicalReactions":[{"directionType":"right-to-left","reactionCrossReference":{"database":"Rhea","id":"RHEA:69853"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00048342"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"a 5,6-dihydrouridine in mRNA + NADP(+) = a uridine in mRNA + NADPH + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:69855"},{"database":"Rhea","id":"RHEA-COMP:14658"},{"database":"Rhea","id":"RHEA-COMP:17789"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:57783"},{"database":"ChEBI","id":"CHEBI:58349"},{"database":"ChEBI","id":"CHEBI:65315"},{"database":"ChEBI","id":"CHEBI:74443"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00049447"}]},"physiologicalReactions":[{"directionType":"right-to-left","reactionCrossReference":{"database":"Rhea","id":"RHEA:69857"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00049447"}]}]},{"commentType":"COFACTOR","cofactors":[{"name":"FMN","evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00001917"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU291113"}],"cofactorCrossReference":{"database":"ChEBI","id":"CHEBI:58210"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU291113"}],"value":"Belongs to the dus family. Dus3 subfamily"}],"commentType":"SIMILARITY"}],"features":[{"type":"Domain","location":{"start":{"value":48,"modifier":"EXACT"},"end":{"value":74,"modifier":"EXACT"}},"description":"C3H1-type","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50103"}]},{"type":"Zinc finger","location":{"start":{"value":48,"modifier":"EXACT"},"end":{"value":74,"modifier":"EXACT"}},"description":"C3H1-type","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00723"}]},{"type":"Non-terminal residue","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":1,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AIU49879.1"}]},{"type":"Non-terminal residue","location":{"start":{"value":520,"modifier":"EXACT"},"end":{"value":520,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AIU49879.1"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022630"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU291113"}],"id":"KW-0285","category":"Ligand","name":"Flavoprotein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022643"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU291113"}],"id":"KW-0288","category":"Ligand","name":"FMN"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022723"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00723"}],"id":"KW-0479","category":"Ligand","name":"Metal-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022664"}],"id":"KW-0507","category":"Biological process","name":"mRNA processing"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023027"}],"id":"KW-0520","category":"Ligand","name":"NAD"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022857"}],"id":"KW-0521","category":"Ligand","name":"NADP"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023002"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU291113"}],"id":"KW-0560","category":"Molecular function","name":"Oxidoreductase"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022737"}],"id":"KW-0677","category":"Domain","name":"Repeat"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022694"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU291113"}],"id":"KW-0819","category":"Biological process","name":"tRNA processing"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022833"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00723"}],"id":"KW-0862","category":"Ligand","name":"Zinc"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022771"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00723"}],"id":"KW-0863","category":"Domain","name":"Zinc-finger"}],"references":[{"referenceNumber":1,"citation":{"id":"25249442","citationType":"journal article","authors":["Zeng L.","Zhang Q.","Sun R.","Kong H.","Zhang N.","Ma H."],"citationCrossReferences":[{"database":"PubMed","id":"25249442"},{"database":"DOI","id":"10.1038/ncomms5956"}],"title":"Resolution of deep angiosperm phylogeny using conserved nuclear genes and estimates of early divergence times.","publicationDate":"2014","journal":"Nat. Commun.","firstPage":"4956","lastPage":"4956","volume":"5"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AIU49879.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"KM399223","properties":[{"key":"ProteinId","value":"AIU49879.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"AlphaFoldDB","id":"A0A097PPC0","properties":[{"key":"Description","value":"-"}]},{"database":"GO","id":"GO:0050660","properties":[{"key":"GoTerm","value":"F:flavin adenine dinucleotide binding"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniRule"}]},{"database":"GO","id":"GO:0046872","properties":[{"key":"GoTerm","value":"F:metal ion binding"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniRule"}]},{"database":"GO","id":"GO:0106414","properties":[{"key":"GoTerm","value":"F:mRNA dihydrouridine synthase activity"},{"key":"GoEvidenceType","value":"IEA:RHEA"}]},{"database":"GO","id":"GO:0003723","properties":[{"key":"GoTerm","value":"F:RNA binding"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:0102265","properties":[{"key":"GoTerm","value":"F:tRNA-dihydrouridine47 synthase activity"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-EC"}]},{"database":"CDD","id":"cd02801","properties":[{"key":"EntryName","value":"DUS_like_FMN"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.20.20.70:FF:000067","properties":[{"key":"EntryName","value":"tRNA-dihydrouridine(47) synthase [NAD(P)(+)]"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.20.20.70","properties":[{"key":"EntryName","value":"Aldolase class I"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR013785","properties":[{"key":"EntryName","value":"Aldolase_TIM"}]},{"database":"InterPro","id":"IPR035587","properties":[{"key":"EntryName","value":"DUS-like_FMN-bd"}]},{"database":"InterPro","id":"IPR018517","properties":[{"key":"EntryName","value":"tRNA_hU_synthase_CS"}]},{"database":"InterPro","id":"IPR000571","properties":[{"key":"EntryName","value":"Znf_CCCH"}]},{"database":"PANTHER","id":"PTHR45846","properties":[{"key":"EntryName","value":"TRNA-DIHYDROURIDINE(47) SYNTHASE [NAD(P)(+)]-LIKE"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR45846:SF1","properties":[{"key":"EntryName","value":"TRNA-DIHYDROURIDINE(47) SYNTHASE [NAD(P)(+)]-LIKE"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF01207","properties":[{"key":"EntryName","value":"Dus"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF25585","properties":[{"key":"EntryName","value":"zf-CCCH_DUS3L"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF51395","properties":[{"key":"EntryName","value":"FMN-linked oxidoreductases"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS01136","properties":[{"key":"EntryName","value":"UPF0034"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50103","properties":[{"key":"EntryName","value":"ZF_C3H1"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"EELIARSIAPVKAQYICTPPPLSVVKEKKSKRQLKRERKQEKGSVLNICPHIAKSGNVDACRFGSNCRFNHDLGAFLAQKPADLEGICPFCPYGVSCRFFNTHKTKSSEINNLKKEVQKLLWKNKFKFPKADAELKLRGLELRPSKKAKELILKPHIRERKLIDFRGKLYLAPLTTVGNLPFRRICKVLGADITCGEMAMCTNLLQGQASEWALLRRHSSEDLFGVQICGAYPDTITRTAELIDQECTVDFIDINMGCPIDIVVNKGAGSSLLTKPMRIKNIAQAASSTISKPITLKVRTGYFEGRNRIDSLISDISYWGVSALTVHGRSRQQRYSKLADWDYIYQCAKKAPDVMQILGNGDIFSYVDWNKHTSECPELSSCMIARGALIKPWLFTEIKEQRHWDISSCERLNIFKDYVNFGLEHWGSDTKGVETTRHFLLEWLSYAHRYVPVGLLEVIPQRINWRSPGYVGRDDLETLMASDSAADWVRISELLLGKVPEGFTFAPKHKSNAYDRTENG","length":520,"molWeight":58951,"crc64":"6AF6DF4617B41E3E","md5":"BB98A0238C742B63E9D7D0BA4A76B1D8"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"CATALYTIC ACTIVITY":4,"COFACTOR":1,"SIMILARITY":1},"countByFeatureType":{"Domain":1,"Zinc finger":1,"Non-terminal residue":2},"uniParcId":"UPI00052AFFE9"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0A7U3NRB8","uniProtkbId":"A0A7U3NRB8_9LILI","entryAudit":{"firstPublicDate":"2021-06-02","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2021-06-02","entryVersion":16,"sequenceVersion":1},"annotationScore":3.0,"organism":{"scientificName":"Lilium brownii","commonName":"Hong Kong lily","taxonId":82312,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"QOW94463.1"}],"lineage":["Eukaryota","Viridiplantae","Streptophyta","Embryophyta","Tracheophyta","Spermatophyta","Magnoliopsida","Liliopsida","Liliales","Liliaceae","Lilium"]},"proteinExistence":"2: Evidence at transcript level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00012460"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU362093"}],"value":"Glucose-1-phosphate adenylyltransferase"},"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00012460"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU362093"}],"value":"2.7.7.27"}]},"alternativeNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU362093"}],"value":"ADP-glucose pyrophosphorylase"}}]},"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU362093"}],"value":"This protein plays a role in synthesis of starch. It catalyzes the synthesis of the activated glycosyl donor, ADP-glucose from Glc-1-P and ATP"}],"commentType":"FUNCTION"},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"alpha-D-glucose 1-phosphate + ATP + H(+) = ADP-alpha-D-glucose + diphosphate","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:12120"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:30616"},{"database":"ChEBI","id":"CHEBI:33019"},{"database":"ChEBI","id":"CHEBI:57498"},{"database":"ChEBI","id":"CHEBI:58601"}],"ecNumber":"2.7.7.27","evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00000956"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU362093"}]}},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004727"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU362093"}],"value":"Glycan biosynthesis; starch biosynthesis"}],"commentType":"PATHWAY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU362093"}],"value":"Heterotetramer"}],"commentType":"SUBUNIT"},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU362093"}],"value":"Plastid, chloroplast","id":"SL-0049"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00010443"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU362093"}],"value":"Belongs to the bacterial/plant glucose-1-phosphate adenylyltransferase family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Domain","location":{"start":{"value":94,"modifier":"EXACT"},"end":{"value":367,"modifier":"EXACT"}},"description":"Nucleotidyl transferase","evidences":[{"evidenceCode":"ECO:0000259","source":"Pfam","id":"PF00483"}]},{"type":"Domain","location":{"start":{"value":387,"modifier":"EXACT"},"end":{"value":521,"modifier":"EXACT"}},"description":"GLGC left-handed parallel beta-helix","evidences":[{"evidenceCode":"ECO:0000259","source":"Pfam","id":"PF25247"}]},{"type":"Region","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":42,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":26,"modifier":"EXACT"},"end":{"value":42,"modifier":"EXACT"}},"description":"Polar residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022533"}],"id":"KW-0021","category":"Molecular function","name":"Allosteric enzyme"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022840"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU362093"}],"id":"KW-0067","category":"Ligand","name":"ATP-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU362093"}],"id":"KW-0150","category":"Cellular component","name":"Chloroplast"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022741"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU362093"}],"id":"KW-0547","category":"Ligand","name":"Nucleotide-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022695"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU362093"}],"id":"KW-0548","category":"Molecular function","name":"Nucleotidyltransferase"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU362093"}],"id":"KW-0934","category":"Cellular component","name":"Plastid"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022922"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU362093"}],"id":"KW-0750","category":"Biological process","name":"Starch biosynthesis"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022679"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU362093"}],"id":"KW-0808","category":"Molecular function","name":"Transferase"}],"references":[{"referenceNumber":1,"citation":{"id":"CI-58OFIJ08MNBUD","citationType":"submission","authors":["Wu Y.","Sun M.","Min R.","Gao C.","Li S.","Ren Z.","Xia Y."],"publicationDate":"JUL-2020","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"QOW94463.1"}],"value":"Bulb","type":"TISSUE"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"QOW94463.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"MT740692","properties":[{"key":"ProteinId","value":"QOW94463.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"AlphaFoldDB","id":"A0A7U3NRB8","properties":[{"key":"Description","value":"-"}]},{"database":"UniPathway","id":"UPA00152","properties":[{"key":"RectionId","value":"-"}]},{"database":"GO","id":"GO:0009507","properties":[{"key":"GoTerm","value":"C:chloroplast"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0008878","properties":[{"key":"GoTerm","value":"F:glucose-1-phosphate adenylyltransferase activity"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-EC"}]},{"database":"GO","id":"GO:0005978","properties":[{"key":"GoTerm","value":"P:glycogen biosynthetic process"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0019252","properties":[{"key":"GoTerm","value":"P:starch biosynthetic process"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniPathway"}]},{"database":"CDD","id":"cd02508","properties":[{"key":"EntryName","value":"ADP_Glucose_PP"},{"key":"MatchStatus","value":"1"}]},{"database":"CDD","id":"cd04651","properties":[{"key":"EntryName","value":"LbH_G1P_AT_C"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.160.10.10:FF:000010","properties":[{"key":"EntryName","value":"Glucose-1-phosphate adenylyltransferase"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.90.550.10:FF:000030","properties":[{"key":"EntryName","value":"Glucose-1-phosphate adenylyltransferase"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.160.10.10","properties":[{"key":"EntryName","value":"Hexapeptide repeat proteins"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.90.550.10","properties":[{"key":"EntryName","value":"Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR011831","properties":[{"key":"EntryName","value":"ADP-Glc_PPase"}]},{"database":"InterPro","id":"IPR005836","properties":[{"key":"EntryName","value":"ADP_Glu_pyroP_CS"}]},{"database":"InterPro","id":"IPR064045","properties":[{"key":"EntryName","value":"LbH_GLGC"}]},{"database":"InterPro","id":"IPR005835","properties":[{"key":"EntryName","value":"NTP_transferase_dom"}]},{"database":"InterPro","id":"IPR029044","properties":[{"key":"EntryName","value":"Nucleotide-diphossugar_trans"}]},{"database":"InterPro","id":"IPR011004","properties":[{"key":"EntryName","value":"Trimer_LpxA-like_sf"}]},{"database":"NCBIfam","id":"TIGR02091","properties":[{"key":"EntryName","value":"glgC"},{"key":"MatchStatus","value":"1"}]},{"database":"NCBIfam","id":"NF002772","properties":[{"key":"EntryName","value":"PRK02862.1"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR43523:SF12","properties":[{"key":"EntryName","value":"GLUCOSE-1-PHOSPHATE ADENYLYLTRANSFERASE LARGE SUBUNIT 1, CHLOROPLASTIC-RELATED"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR43523","properties":[{"key":"EntryName","value":"GLUCOSE-1-PHOSPHATE ADENYLYLTRANSFERASE-RELATED"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF25247","properties":[{"key":"EntryName","value":"LbH_GLGC"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00483","properties":[{"key":"EntryName","value":"NTP_transferase"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF53448","properties":[{"key":"EntryName","value":"Nucleotide-diphospho-sugar transferases"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF51161","properties":[{"key":"EntryName","value":"Trimeric LpxA-like enzymes"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00808","properties":[{"key":"EntryName","value":"ADP_GLC_PYROPHOSPH_1"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00809","properties":[{"key":"EntryName","value":"ADP_GLC_PYROPHOSPH_2"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00810","properties":[{"key":"EntryName","value":"ADP_GLC_PYROPHOSPH_3"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MAMAAIGVSTPFPRTLPSHRTPKPPTQSLRTPTPAALSSSAHISGDKLAAPAALGRRNAATGGRAPLIVSPKAVSDSKNSQTCLDPEASKSVLGIILGGGAGTRLYPLTKKRAKPAVPLGANYRLIDIPVSNCLNSDISKIYVLTQFNSASLNRHLSRAYASNMGGYQNEGFVEVLAAQQSPENPNWFQGTADAVRQYLWLFEEHNVLEFLILAGDHLYRMDYEKFIQAHRETDADITVAALPMDEKRATAFGLMKIDEEGRIIEFAEKPKGEKLKAMKVDTTILGLDDARAKEMPFIASMGIYVISKDVMLKLLRENFPDANDFGSEVIPGATSIGLRVQAYLYDGYWEDIGTIEAFYNANLGITKKPVPDFSFYDRSSPIYTQPRYLPPSKMLDADVTDSVIGEGCVIKNCKIHHSVIGLRSCISEGAIIEDTLLMGADYYETDADRRFLYAKGSVPIGIGKNSHITRAIIDKNARIGDNVKIINTENVQEAARETDGYFIKSGIVTIIKDALIPSGTVI","length":522,"molWeight":56980,"crc64":"5DAF0AA681910B08","md5":"ACD6CE91F3631889B80FA995AA067AD8"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"CATALYTIC ACTIVITY":1,"PATHWAY":1,"SUBUNIT":1,"SUBCELLULAR LOCATION":1,"SIMILARITY":1},"countByFeatureType":{"Domain":2,"Region":1,"Compositional bias":1},"uniParcId":"UPI0018BFB449"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0A097PJ94","uniProtkbId":"A0A097PJ94_9LILI","entryAudit":{"firstPublicDate":"2015-01-07","lastAnnotationUpdateDate":"2026-11-04","lastSequenceUpdateDate":"2015-01-07","entryVersion":40,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Lilium brownii","commonName":"Hong Kong lily","taxonId":82312,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AIU48100.1"}],"lineage":["Eukaryota","Viridiplantae","Streptophyta","Embryophyta","Tracheophyta","Spermatophyta","Magnoliopsida","Liliopsida","Liliales","Liliaceae","Lilium"]},"proteinExistence":"2: Evidence at transcript level","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AIU48100.1"}],"value":"Structural maintenance of chromosomes protein 1"}}],"flag":"Fragment"},"comments":[{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004286"}],"value":"Chromosome","id":"SL-0468"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004123"}],"value":"Nucleus","id":"SL-0191"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00005597"}],"value":"Belongs to the SMC family. SMC1 subfamily"}],"commentType":"SIMILARITY"}],"features":[{"type":"Domain","location":{"start":{"value":494,"modifier":"EXACT"},"end":{"value":593,"modifier":"EXACT"}},"description":"SMC hinge","evidences":[{"evidenceCode":"ECO:0000259","source":"SMART","id":"SM00968"}]},{"type":"Region","location":{"start":{"value":431,"modifier":"EXACT"},"end":{"value":452,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Coiled coil","location":{"start":{"value":140,"modifier":"EXACT"},"end":{"value":174,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Coils"}]},{"type":"Coiled coil","location":{"start":{"value":214,"modifier":"EXACT"},"end":{"value":248,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Coils"}]},{"type":"Coiled coil","location":{"start":{"value":284,"modifier":"EXACT"},"end":{"value":339,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Coils"}]},{"type":"Coiled coil","location":{"start":{"value":635,"modifier":"EXACT"},"end":{"value":772,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Coils"}]},{"type":"Coiled coil","location":{"start":{"value":796,"modifier":"EXACT"},"end":{"value":830,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Coils"}]},{"type":"Compositional bias","location":{"start":{"value":431,"modifier":"EXACT"},"end":{"value":443,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Non-terminal residue","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":1,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AIU48100.1"}]},{"type":"Non-terminal residue","location":{"start":{"value":1053,"modifier":"EXACT"},"end":{"value":1053,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AIU48100.1"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023306"}],"id":"KW-0131","category":"Biological process","name":"Cell cycle"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022618"}],"id":"KW-0132","category":"Biological process","name":"Cell division"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022454"}],"id":"KW-0158","category":"Cellular component","name":"Chromosome"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023054"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"Coils"}],"id":"KW-0175","category":"Domain","name":"Coiled coil"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023254"}],"id":"KW-0469","category":"Biological process","name":"Meiosis"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022776"}],"id":"KW-0498","category":"Biological process","name":"Mitosis"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023242"}],"id":"KW-0539","category":"Cellular component","name":"Nucleus"}],"references":[{"referenceNumber":1,"citation":{"id":"25249442","citationType":"journal article","authors":["Zeng L.","Zhang Q.","Sun R.","Kong H.","Zhang N.","Ma H."],"citationCrossReferences":[{"database":"PubMed","id":"25249442"},{"database":"DOI","id":"10.1038/ncomms5956"}],"title":"Resolution of deep angiosperm phylogeny using conserved nuclear genes and estimates of early divergence times.","publicationDate":"2014","journal":"Nat. Commun.","firstPage":"4956","lastPage":"4956","volume":"5"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AIU48100.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"KM397433","properties":[{"key":"ProteinId","value":"AIU48100.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"AlphaFoldDB","id":"A0A097PJ94","properties":[{"key":"Description","value":"-"}]},{"database":"GO","id":"GO:0008278","properties":[{"key":"GoTerm","value":"C:cohesin complex"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0005634","properties":[{"key":"GoTerm","value":"C:nucleus"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0005524","properties":[{"key":"GoTerm","value":"F:ATP binding"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0016887","properties":[{"key":"GoTerm","value":"F:ATP hydrolysis activity"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0003677","properties":[{"key":"GoTerm","value":"F:DNA binding"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:0007062","properties":[{"key":"GoTerm","value":"P:sister chromatid cohesion"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"CDD","id":"cd03275","properties":[{"key":"EntryName","value":"ABC_SMC1_euk"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.20.1060.20","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.30.70.1620","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.40.50.300","properties":[{"key":"EntryName","value":"P-loop containing nucleotide triphosphate hydrolases"},{"key":"MatchStatus","value":"2"}]},{"database":"InterPro","id":"IPR027417","properties":[{"key":"EntryName","value":"P-loop_NTPase"}]},{"database":"InterPro","id":"IPR003395","properties":[{"key":"EntryName","value":"RecF/RecN/SMC_N"}]},{"database":"InterPro","id":"IPR024704","properties":[{"key":"EntryName","value":"SMC"}]},{"database":"InterPro","id":"IPR028468","properties":[{"key":"EntryName","value":"Smc1_ABC"}]},{"database":"InterPro","id":"IPR010935","properties":[{"key":"EntryName","value":"SMC_hinge"}]},{"database":"InterPro","id":"IPR036277","properties":[{"key":"EntryName","value":"SMC_hinge_sf"}]},{"database":"PANTHER","id":"PTHR18937:SF12","properties":[{"key":"EntryName","value":"STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR18937","properties":[{"key":"EntryName","value":"STRUCTURAL MAINTENANCE OF CHROMOSOMES SMC FAMILY MEMBER"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF06470","properties":[{"key":"EntryName","value":"SMC_hinge"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF02463","properties":[{"key":"EntryName","value":"SMC_N"},{"key":"MatchStatus","value":"1"}]},{"database":"PIRSF","id":"PIRSF005719","properties":[{"key":"EntryName","value":"SMC"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00968","properties":[{"key":"EntryName","value":"SMC_hinge"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF52540","properties":[{"key":"EntryName","value":"P-loop containing nucleoside triphosphate hydrolases"},{"key":"MatchStatus","value":"2"}]},{"database":"SUPFAM","id":"SSF75553","properties":[{"key":"EntryName","value":"Smc hinge domain"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"FQSIGPFYDFTAIIGPNGAGKSNLMDAISFVLGVRSTHLRGAQLRDLIYAFDDREKEQGGRRAFVRLVYQMGNGSELQFTRRITDAGGSDYRIDGKAVTWDAYNAKLKSLGILVQARNFLVFQGDVESIASKNPKELSALLEQISGSDELKKDYEDLEEQKARAEEQTAFVYQEKRTTVMERKQKKAQKEEAEKHLRLQDQLKVLKKDYFLWKLRNFEKDTEKINDELEKERKSLEEEDKIREKCESEADIKKKEQAGYLKEITICEKKIAKKKIELDKKQPELLKLKEEISRINSKIKSSKKELEKKKVDHKKHVREIERLQKDLGDVAEALNELTEQDKDGVGKLQLAASQLEEYTRIKQEAGTKTAKLNDEKEVLDRRLHADVDAQKNMEENLQQLINREQELSSQEEQMQTRLKKILAASAKHKEDLSRAKKELSEISKKRQTSGTKYQNLKQRIDEIDLQLRELKADKYENERDNRLFETVQSLKRLFPGVHGRMLELCKPSQKKYNLAVTVAMGKFMEAVQRLPPQTFIPLQSVRVKPIVEKMRTLGGTAQLVFDVIQFDRSLEKAVLFAVGNTLVCDTLEEAKVLSWGRERHKVVTVDGILLTKSGTMTGGISGGMEARSNKWDDSTIQALKKKKQQWESEMEELGSLRELQVKESEASEKYAGLEKKIHYSNIEEKSIQEKLSKLTEEKKIVKEEIARLKPDLQKLKSLIAKRTEDIRKIEKRIHEVVDRIYEDFSKSVGVNNIREYEENYLKAAQEMAERKQTLNSDECEMAIEEIKKNTTNIVGIIGKLKRQITSKETQLEQLRSRKQEVLENCELEQIQLPTVDPMETGSSTPGPVFDYSKLSRAYLQDMGPSEREKVEADFKQNVSTMVAEIERTAPNLKALDQYEALQVKERTVIERFEATRREEKEISDKFNSVKRRRYELFMEAFDHISKIIDKIYKQLTKSHTHPLGGNAYLTLENDDEPFLHGIKYTAMPPTKRFREMEQLSGGEKTVAALALLFSIHSYRPSPFFILDEVDAALDNLNVAKVAGFIRSKSCAGAR","length":1053,"molWeight":121255,"crc64":"9751B8003EBF1901","md5":"3F1063715752796A0F5C379CA437BC9E"},"extraAttributes":{"countByCommentType":{"SUBCELLULAR LOCATION":1,"SIMILARITY":1},"countByFeatureType":{"Domain":1,"Region":1,"Coiled coil":5,"Compositional bias":1,"Non-terminal residue":2},"uniParcId":"UPI00052A3BF6"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0A097PJK9","uniProtkbId":"A0A097PJK9_9LILI","entryAudit":{"firstPublicDate":"2015-01-07","lastAnnotationUpdateDate":"2026-01-28","lastSequenceUpdateDate":"2015-01-07","entryVersion":28,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Lilium brownii","commonName":"Hong Kong lily","taxonId":82312,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AIU48210.1"}],"lineage":["Eukaryota","Viridiplantae","Streptophyta","Embryophyta","Tracheophyta","Spermatophyta","Magnoliopsida","Liliopsida","Liliales","Liliaceae","Lilium"]},"proteinExistence":"2: Evidence at transcript level","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AIU48210.1"}],"value":"MLH1"}}],"flag":"Fragment"},"comments":[{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004123"}],"value":"Nucleus","id":"SL-0191"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00006082"}],"value":"Belongs to the DNA mismatch repair MutL/HexB family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Domain","location":{"start":{"value":11,"modifier":"EXACT"},"end":{"value":133,"modifier":"EXACT"}},"description":"DNA mismatch repair protein S5","evidences":[{"evidenceCode":"ECO:0000259","source":"SMART","id":"SM01340"}]},{"type":"Region","location":{"start":{"value":148,"modifier":"EXACT"},"end":{"value":176,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":148,"modifier":"EXACT"},"end":{"value":173,"modifier":"EXACT"}},"description":"Polar residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Non-terminal residue","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":1,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AIU48210.1"}]},{"type":"Non-terminal residue","location":{"start":{"value":466,"modifier":"EXACT"},"end":{"value":466,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AIU48210.1"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022763"}],"id":"KW-0227","category":"Biological process","name":"DNA damage"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023204"}],"id":"KW-0234","category":"Biological process","name":"DNA repair"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023242"}],"id":"KW-0539","category":"Cellular component","name":"Nucleus"}],"references":[{"referenceNumber":1,"citation":{"id":"25249442","citationType":"journal article","authors":["Zeng L.","Zhang Q.","Sun R.","Kong H.","Zhang N.","Ma H."],"citationCrossReferences":[{"database":"PubMed","id":"25249442"},{"database":"DOI","id":"10.1038/ncomms5956"}],"title":"Resolution of deep angiosperm phylogeny using conserved nuclear genes and estimates of early divergence times.","publicationDate":"2014","journal":"Nat. Commun.","firstPage":"4956","lastPage":"4956","volume":"5"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AIU48210.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"KM397544","properties":[{"key":"ProteinId","value":"AIU48210.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"AlphaFoldDB","id":"A0A097PJK9","properties":[{"key":"Description","value":"-"}]},{"database":"GO","id":"GO:0032389","properties":[{"key":"GoTerm","value":"C:MutLalpha complex"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:0005524","properties":[{"key":"GoTerm","value":"F:ATP binding"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0016887","properties":[{"key":"GoTerm","value":"F:ATP hydrolysis activity"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0140664","properties":[{"key":"GoTerm","value":"F:ATP-dependent DNA damage sensor activity"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0030983","properties":[{"key":"GoTerm","value":"F:mismatched DNA binding"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0006298","properties":[{"key":"GoTerm","value":"P:mismatch repair"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"CDD","id":"cd03483","properties":[{"key":"EntryName","value":"MutL_Trans_MLH1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.30.230.10:FF:000014","properties":[{"key":"EntryName","value":"DNA mismatch repair protein Mlh1"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.30.230.10","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR013507","properties":[{"key":"EntryName","value":"DNA_mismatch_S5_2-like"}]},{"database":"InterPro","id":"IPR032189","properties":[{"key":"EntryName","value":"Mlh1_C"}]},{"database":"InterPro","id":"IPR038973","properties":[{"key":"EntryName","value":"MutL/Mlh/Pms-like"}]},{"database":"InterPro","id":"IPR020568","properties":[{"key":"EntryName","value":"Ribosomal_Su5_D2-typ_SF"}]},{"database":"InterPro","id":"IPR014721","properties":[{"key":"EntryName","value":"Ribsml_uS5_D2-typ_fold_subgr"}]},{"database":"PANTHER","id":"PTHR10073","properties":[{"key":"EntryName","value":"DNA MISMATCH REPAIR PROTEIN MLH, PMS, MUTL"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR10073:SF12","properties":[{"key":"EntryName","value":"DNA MISMATCH REPAIR PROTEIN MLH1"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF01119","properties":[{"key":"EntryName","value":"DNA_mis_repair"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF16413","properties":[{"key":"EntryName","value":"Mlh1_C"},{"key":"MatchStatus","value":"2"}]},{"database":"SMART","id":"SM01340","properties":[{"key":"EntryName","value":"DNA_mis_repair"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF54211","properties":[{"key":"EntryName","value":"Ribosomal protein S5 domain 2-like"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"TISACSRLDAIRTVYGVSVARDLMEITASDDNSAQSIFKMDGFISNANYMAKKTTMVLFINDRLVECTALKRALEIVYSATLPKASKPFIYMSIKLPSEHVDVNIHPTKREVSLLNQESLVDTIQNAVECKLTKCNITRTFLTQDINSSPPTRSIAKDTQCNSSVSGTKSQKVPVQKMVRTDSRDPFGRLHAYLQHGPALQQDTIPDLASVRNAVRMRRNPKEASDISCIHELLRDIDSSVHAGLLDIVKNCTFVGLADEVFAVLQHNTHLYLMNVVNVSKELMYQQAIRRFSRFNAIQLSEPAPLLELLMMALKEEDLESVGDGDDSLKQKIAEMNTELLIQKTALLDECFSIHIDQQGNEVFAVLQHNTHLYLMNVVNVSKELMYQQAIRRFSRFNAIQLSEPAPLLELLMMALKEEDHPPVLPNPSGSGIQFYKKDVDHDLLAEAETAWISVNGRFSMSYFHH","length":466,"molWeight":52441,"crc64":"BFEE42C156361CD6","md5":"F1679F60265DA9D04B61BAC77B5A79D6"},"extraAttributes":{"countByCommentType":{"SUBCELLULAR LOCATION":1,"SIMILARITY":1},"countByFeatureType":{"Domain":1,"Region":1,"Compositional bias":1,"Non-terminal residue":2},"uniParcId":"UPI00052AC256"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0A097PK68","uniProtkbId":"A0A097PK68_9LILI","entryAudit":{"firstPublicDate":"2015-01-07","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2015-01-07","entryVersion":30,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Lilium brownii","commonName":"Hong Kong lily","taxonId":82312,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AIU48431.1"}],"lineage":["Eukaryota","Viridiplantae","Streptophyta","Embryophyta","Tracheophyta","Spermatophyta","Magnoliopsida","Liliopsida","Liliales","Liliaceae","Lilium"]},"proteinExistence":"2: Evidence at transcript level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00017858"}],"value":"Homoserine kinase"},"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00012078"}],"value":"2.7.1.39"}]},"flag":"Fragment"},"comments":[{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"L-homoserine + ATP = O-phospho-L-homoserine + ADP + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:13985"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:30616"},{"database":"ChEBI","id":"CHEBI:57476"},{"database":"ChEBI","id":"CHEBI:57590"},{"database":"ChEBI","id":"CHEBI:456216"}],"ecNumber":"2.7.1.39","evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00049913"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:13986"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00049913"}]}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00005015"}],"value":"Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 4/5"}],"commentType":"PATHWAY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00007370"}],"value":"Belongs to the GHMP kinase family. Homoserine kinase subfamily"}],"commentType":"SIMILARITY"}],"features":[{"type":"Domain","location":{"start":{"value":74,"modifier":"EXACT"},"end":{"value":153,"modifier":"EXACT"}},"description":"GHMP kinase N-terminal","evidences":[{"evidenceCode":"ECO:0000259","source":"Pfam","id":"PF00288"}]},{"type":"Domain","location":{"start":{"value":216,"modifier":"EXACT"},"end":{"value":290,"modifier":"EXACT"}},"description":"GHMP kinase C-terminal","evidences":[{"evidenceCode":"ECO:0000259","source":"Pfam","id":"PF08544"}]},{"type":"Non-terminal residue","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":1,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AIU48431.1"}]},{"type":"Non-terminal residue","location":{"start":{"value":316,"modifier":"EXACT"},"end":{"value":316,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AIU48431.1"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022605"}],"id":"KW-0028","category":"Biological process","name":"Amino-acid biosynthesis"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022840"}],"id":"KW-0067","category":"Ligand","name":"ATP-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022777"},{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AIU48431.1"}],"id":"KW-0418","category":"Molecular function","name":"Kinase"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022741"}],"id":"KW-0547","category":"Ligand","name":"Nucleotide-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022697"}],"id":"KW-0791","category":"Biological process","name":"Threonine biosynthesis"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022679"}],"id":"KW-0808","category":"Molecular function","name":"Transferase"}],"references":[{"referenceNumber":1,"citation":{"id":"25249442","citationType":"journal article","authors":["Zeng L.","Zhang Q.","Sun R.","Kong H.","Zhang N.","Ma H."],"citationCrossReferences":[{"database":"PubMed","id":"25249442"},{"database":"DOI","id":"10.1038/ncomms5956"}],"title":"Resolution of deep angiosperm phylogeny using conserved nuclear genes and estimates of early divergence times.","publicationDate":"2014","journal":"Nat. Commun.","firstPage":"4956","lastPage":"4956","volume":"5"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AIU48431.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"KM397765","properties":[{"key":"ProteinId","value":"AIU48431.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"AlphaFoldDB","id":"A0A097PK68","properties":[{"key":"Description","value":"-"}]},{"database":"UniPathway","id":"UPA00050","properties":[{"key":"RectionId","value":"UER00064"}]},{"database":"GO","id":"GO:0005524","properties":[{"key":"GoTerm","value":"F:ATP binding"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0004413","properties":[{"key":"GoTerm","value":"F:homoserine kinase activity"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-EC"}]},{"database":"GO","id":"GO:0009088","properties":[{"key":"GoTerm","value":"P:L-threonine biosynthetic process"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniPathway"}]},{"database":"Gene3D","id":"3.30.230.10","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.30.70.890","properties":[{"key":"EntryName","value":"GHMP kinase, C-terminal domain"},{"key":"MatchStatus","value":"1"}]},{"database":"HAMAP","id":"MF_00384","properties":[{"key":"EntryName","value":"Homoser_kinase"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR013750","properties":[{"key":"EntryName","value":"GHMP_kinase_C_dom"}]},{"database":"InterPro","id":"IPR036554","properties":[{"key":"EntryName","value":"GHMP_kinase_C_sf"}]},{"database":"InterPro","id":"IPR006204","properties":[{"key":"EntryName","value":"GHMP_kinase_N_dom"}]},{"database":"InterPro","id":"IPR006203","properties":[{"key":"EntryName","value":"GHMP_knse_ATP-bd_CS"}]},{"database":"InterPro","id":"IPR000870","properties":[{"key":"EntryName","value":"Homoserine_kinase"}]},{"database":"InterPro","id":"IPR020568","properties":[{"key":"EntryName","value":"Ribosomal_Su5_D2-typ_SF"}]},{"database":"InterPro","id":"IPR014721","properties":[{"key":"EntryName","value":"Ribsml_uS5_D2-typ_fold_subgr"}]},{"database":"NCBIfam","id":"NF002288","properties":[{"key":"EntryName","value":"PRK01212.1-4"},{"key":"MatchStatus","value":"1"}]},{"database":"NCBIfam","id":"TIGR00191","properties":[{"key":"EntryName","value":"thrB"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR20861:SF1","properties":[{"key":"EntryName","value":"HOMOSERINE KINASE"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR20861","properties":[{"key":"EntryName","value":"HOMOSERINE/4-DIPHOSPHOCYTIDYL-2-C-METHYL-D-ERYTHRITOL KINASE"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF08544","properties":[{"key":"EntryName","value":"GHMP_kinases_C"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00288","properties":[{"key":"EntryName","value":"GHMP_kinases_N"},{"key":"MatchStatus","value":"1"}]},{"database":"PIRSF","id":"PIRSF000676","properties":[{"key":"EntryName","value":"Homoser_kin"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR00958","properties":[{"key":"EntryName","value":"HOMSERKINASE"}]},{"database":"SUPFAM","id":"SSF55060","properties":[{"key":"EntryName","value":"GHMP Kinase, C-terminal domain"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF54211","properties":[{"key":"EntryName","value":"Ribosomal protein S5 domain 2-like"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00627","properties":[{"key":"EntryName","value":"GHMP_KINASES_ATP"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"DPAPRLRSVSTFAPATVANLGPAFDFLGCAVDVLGDTASLSVDSSIPPGTLSISSITRLRLDPLWNCAGIAAIAVMRMLSVRSVGLSLSLHKGLPLGSGLGSSAASAAAAAIAVNALFGDPLSPADLILAGLESEKKVSGYHADNIAPAIMGGFALIRSYTPLDIIHLEFPADKDLFFVLVSPDFEAPTKKMREALREEVTMKEHVRNSSQAAALVAAVLQGDARVLGSAMSCDEIVEPRRAPLIPGMVEVKRAAIEAGAFGCTISGAGPTAVAVIDSEEKGKEIGVRMVEAFLAAGKLNASVTVARLDRIGARVI","length":316,"molWeight":32652,"crc64":"D454290F0F3E7828","md5":"B9334147D72B4FFDF65D704E26E05B66"},"extraAttributes":{"countByCommentType":{"CATALYTIC ACTIVITY":1,"PATHWAY":1,"SIMILARITY":1},"countByFeatureType":{"Domain":2,"Non-terminal residue":2},"uniParcId":"UPI00052A951A"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0A097PKN6","uniProtkbId":"A0A097PKN6_9LILI","entryAudit":{"firstPublicDate":"2015-01-07","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2015-01-07","entryVersion":25,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Lilium brownii","commonName":"Hong Kong lily","taxonId":82312,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AIU48587.1"}],"lineage":["Eukaryota","Viridiplantae","Streptophyta","Embryophyta","Tracheophyta","Spermatophyta","Magnoliopsida","Liliopsida","Liliales","Liliaceae","Lilium"]},"proteinExistence":"2: Evidence at transcript level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU366043"}],"value":"Methyltransferase"},"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU366043"}],"value":"2.1.1.-"}]},"flag":"Fragment"},"comments":[{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00037847"}],"value":"Endomembrane system","id":"SL-0147"},"topology":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00037847"}],"value":"Single-pass membrane protein","id":"SL-9904"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004606"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU366043"}],"value":"Membrane","id":"SL-0162"},"topology":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004606"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU366043"}],"value":"Single-pass type II membrane protein","id":"SL-9906"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00008361"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU366043"}],"value":"Belongs to the methyltransferase superfamily"}],"commentType":"SIMILARITY"}],"features":[{"type":"Non-terminal residue","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":1,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AIU48587.1"}]},{"type":"Non-terminal residue","location":{"start":{"value":312,"modifier":"EXACT"},"end":{"value":312,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AIU48587.1"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU366043"}],"id":"KW-0325","category":"PTM","name":"Glycoprotein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022603"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU366043"}],"id":"KW-0489","category":"Molecular function","name":"Methyltransferase"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022968"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU366043"}],"id":"KW-0735","category":"Domain","name":"Signal-anchor"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU366043"}],"id":"KW-0808","category":"Molecular function","name":"Transferase"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022968"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU366043"}],"id":"KW-0812","category":"Domain","name":"Transmembrane"}],"references":[{"referenceNumber":1,"citation":{"id":"25249442","citationType":"journal article","authors":["Zeng L.","Zhang Q.","Sun R.","Kong H.","Zhang N.","Ma H."],"citationCrossReferences":[{"database":"PubMed","id":"25249442"},{"database":"DOI","id":"10.1038/ncomms5956"}],"title":"Resolution of deep angiosperm phylogeny using conserved nuclear genes and estimates of early divergence times.","publicationDate":"2014","journal":"Nat. Commun.","firstPage":"4956","lastPage":"4956","volume":"5"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AIU48587.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"KM397925","properties":[{"key":"ProteinId","value":"AIU48587.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"AlphaFoldDB","id":"A0A097PKN6","properties":[{"key":"Description","value":"-"}]},{"database":"GO","id":"GO:0005768","properties":[{"key":"GoTerm","value":"C:endosome"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:0016020","properties":[{"key":"GoTerm","value":"C:membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0005802","properties":[{"key":"GoTerm","value":"C:trans-Golgi network"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:0008757","properties":[{"key":"GoTerm","value":"F:S-adenosylmethionine-dependent methyltransferase activity"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"FunFam","id":"3.40.50.150:FF:000165","properties":[{"key":"EntryName","value":"probable methyltransferase PMT13"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.40.50.150","properties":[{"key":"EntryName","value":"Vaccinia Virus protein VP39"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR004159","properties":[{"key":"EntryName","value":"Put_SAM_MeTrfase"}]},{"database":"InterPro","id":"IPR029063","properties":[{"key":"EntryName","value":"SAM-dependent_MTases_sf"}]},{"database":"PANTHER","id":"PTHR10108:SF763","properties":[{"key":"EntryName","value":"PECTIN METHYLTRANSFERASE QUA3-RELATED"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR10108","properties":[{"key":"EntryName","value":"SAM-DEPENDENT METHYLTRANSFERASE"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF03141","properties":[{"key":"EntryName","value":"Methyltransf_29"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF53335","properties":[{"key":"EntryName","value":"S-adenosyl-L-methionine-dependent methyltransferases"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"CAAEEVDQLPCEDPRRFSQLSREMNFYRERHCPEPEDVPLCLIPPPEGYHVPVPWPESLHKIWHNNMPYNKIADRKGHQGWMKEEGPYFIFPGGGTMFPDGAEQYIEKLGQYIPLNNGVLRTALDMGCGVASFGGFLLKKNVSTLSFAPRDSHKSQIQFALERGIPAFVAMLGTRRLPFPAFSFDLVHCSRCLIPFTAYNASYFIEVDRLLRPGGYLVISGPPVQWSKQEKEWADLQAVARALCYQVIVVDGNTVIWNKPLGDSCFPNQNEFGLDVCSDNNDPNEAWYFKLKKCISKVPPSEEIAVGSILRW","length":312,"molWeight":35330,"crc64":"E2A8F042EC9F6E08","md5":"F040997CA44AB9A51B490990D6AB76CA"},"extraAttributes":{"countByCommentType":{"SUBCELLULAR LOCATION":1,"SIMILARITY":1},"countByFeatureType":{"Non-terminal residue":2},"uniParcId":"UPI00052AC0F9"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0A097PKU6","uniProtkbId":"A0A097PKU6_9LILI","entryAudit":{"firstPublicDate":"2015-01-07","lastAnnotationUpdateDate":"2026-11-04","lastSequenceUpdateDate":"2015-01-07","entryVersion":25,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Lilium brownii","commonName":"Hong Kong lily","taxonId":82312,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AIU48642.1"}],"lineage":["Eukaryota","Viridiplantae","Streptophyta","Embryophyta","Tracheophyta","Spermatophyta","Magnoliopsida","Liliopsida","Liliales","Liliaceae","Lilium"]},"proteinExistence":"2: Evidence at transcript level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00067480"}],"value":"TBC1 domain family member 15"}},"alternativeNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00082539"}],"value":"GTPase-activating protein RAB7"}}],"flag":"Fragment"},"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00055283"}],"value":"Acts as a GTPase activating protein for RAB7A. Does not act on RAB4, RAB5 or RAB6"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00065268"}],"value":"Interacts with non-phosphorylated form of RAB8A; phosphorylation of RAB8A at 'Thr-72' disrupts this interaction. Interacts with ARMC12"}],"commentType":"SUBUNIT"},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004496"}],"value":"Cytoplasm","id":"SL-0086"}}]}],"features":[{"type":"Domain","location":{"start":{"value":327,"modifier":"EXACT"},"end":{"value":537,"modifier":"EXACT"}},"description":"Rab-GAP TBC","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50086"}]},{"type":"Region","location":{"start":{"value":250,"modifier":"EXACT"},"end":{"value":271,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Non-terminal residue","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":1,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AIU48642.1"}]},{"type":"Non-terminal residue","location":{"start":{"value":620,"modifier":"EXACT"},"end":{"value":620,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AIU48642.1"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022990"}],"id":"KW-0007","category":"PTM","name":"Acetylation"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022490"}],"id":"KW-0963","category":"Cellular component","name":"Cytoplasm"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022468"}],"id":"KW-0343","category":"Molecular function","name":"GTPase activation"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022553"}],"id":"KW-0597","category":"PTM","name":"Phosphoprotein"}],"references":[{"referenceNumber":1,"citation":{"id":"25249442","citationType":"journal article","authors":["Zeng L.","Zhang Q.","Sun R.","Kong H.","Zhang N.","Ma H."],"citationCrossReferences":[{"database":"PubMed","id":"25249442"},{"database":"DOI","id":"10.1038/ncomms5956"}],"title":"Resolution of deep angiosperm phylogeny using conserved nuclear genes and estimates of early divergence times.","publicationDate":"2014","journal":"Nat. Commun.","firstPage":"4956","lastPage":"4956","volume":"5"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AIU48642.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"KM397980","properties":[{"key":"ProteinId","value":"AIU48642.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"AlphaFoldDB","id":"A0A097PKU6","properties":[{"key":"Description","value":"-"}]},{"database":"GO","id":"GO:0005737","properties":[{"key":"GoTerm","value":"C:cytoplasm"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0005096","properties":[{"key":"GoTerm","value":"F:GTPase activator activity"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"FunFam","id":"1.10.472.80:FF:000005","properties":[{"key":"EntryName","value":"TBC1 domain family member 15"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.10.8.270:FF:000005","properties":[{"key":"EntryName","value":"TBC1 domain family member 15"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.30.29.230","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.10.8.270","properties":[{"key":"EntryName","value":"putative rabgap domain of human tbc1 domain family member 14 like domains"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.10.472.80","properties":[{"key":"EntryName","value":"Ypt/Rab-GAP domain of gyp1p, domain 3"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR000195","properties":[{"key":"EntryName","value":"Rab-GAP-TBC_dom"}]},{"database":"InterPro","id":"IPR035969","properties":[{"key":"EntryName","value":"Rab-GAP_TBC_sf"}]},{"database":"InterPro","id":"IPR021935","properties":[{"key":"EntryName","value":"SGSM1/2_RBD"}]},{"database":"PANTHER","id":"PTHR22957:SF502","properties":[{"key":"EntryName","value":"SMALL G PROTEIN SIGNALING MODULATOR 2-RELATED"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR22957","properties":[{"key":"EntryName","value":"TBC1 DOMAIN FAMILY MEMBER GTPASE-ACTIVATING PROTEIN"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF12068","properties":[{"key":"EntryName","value":"PH_RBD"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00566","properties":[{"key":"EntryName","value":"RabGAP-TBC"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00164","properties":[{"key":"EntryName","value":"TBC"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF47923","properties":[{"key":"EntryName","value":"Ypt/Rab-GAP domain of gyp1p"},{"key":"MatchStatus","value":"2"}]},{"database":"PROSITE","id":"PS50086","properties":[{"key":"EntryName","value":"TBC_RABGAP"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"AEVVTTSICDSSQSHSAIVYSKDNVAIHPTQYASERISGRLRLIKQDSALFLSWIPYKASSSISGISEKDRKLYTIKLVALSDVRSIRRHTPTLGWQYVIIVLSSGLAFPPLYFYNGGVREFCQTLKRYVLIKRSEDDANVFLMNDFQDPLQRSLSSLELPRAVSIAKGTPHNSVGSISSLHSSDMVNGISSAMTSGVSEYGGRQKHKVHDPARDISIQVLEKFSLVTKFARETTSQLFRESNGFNPYEKKQKNNYAPAATGSPKETQTISDLIPESSDPAEINKLPLIWGKQRQSPLCLEEWAAFIDTEGRIIDSESLKKRIFYGGVEHNLRKEVWKFLLGYHEYNSTYAERDYLASIKKSEYETIKSQWQNISAIQAKRFTKFKERKGLIEKDVVRTDRSISYYDGEDNPNVRLLHDILLTYSFYNFDLGYCQGMSDFLSPILFVMEDESESFWCFVALMERMGPNFNRDQNGMHAQLFALSKLVELLDYPLHNYFKQADCLNYFFCFRWILIQFKREFPYEKIMLLWEVLWTHYLSEHFHLYMCVAILKQYRRKIMDEQMDFDTLLKFINELSDHIDLDRTIREAEALCVLAGENGAASIPPGTPPSLPIDMGLSDD","length":620,"molWeight":71289,"crc64":"8AC39CB5C2FF63D5","md5":"759BF34B1AF7EC8316F1A36AE248B477"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"SUBUNIT":1,"SUBCELLULAR LOCATION":1},"countByFeatureType":{"Domain":1,"Region":1,"Non-terminal residue":2},"uniParcId":"UPI00052A720E"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0A097PL13","uniProtkbId":"A0A097PL13_9LILI","entryAudit":{"firstPublicDate":"2015-01-07","lastAnnotationUpdateDate":"2026-11-04","lastSequenceUpdateDate":"2015-01-07","entryVersion":29,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Lilium brownii","commonName":"Hong Kong lily","taxonId":82312,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AIU48694.1"}],"lineage":["Eukaryota","Viridiplantae","Streptophyta","Embryophyta","Tracheophyta","Spermatophyta","Magnoliopsida","Liliopsida","Liliales","Liliaceae","Lilium"]},"proteinExistence":"2: Evidence at transcript level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00012396"}],"value":"15-cis-phytoene synthase"},"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00012396"}],"value":"2.5.1.32"}]},"flag":"Fragment"},"comments":[{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"(1R,2R,3R)-prephytoene diphosphate = 15-cis-phytoene + diphosphate","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:34479"},{"database":"ChEBI","id":"CHEBI:27787"},{"database":"ChEBI","id":"CHEBI:33019"},{"database":"ChEBI","id":"CHEBI:58011"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00095522"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:34480"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00095522"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"2 (2E,6E,10E)-geranylgeranyl diphosphate = (1R,2R,3R)-prephytoene diphosphate + diphosphate","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:22296"},{"database":"ChEBI","id":"CHEBI:33019"},{"database":"ChEBI","id":"CHEBI:58011"},{"database":"ChEBI","id":"CHEBI:58756"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00095628"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:22297"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00095628"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"2 (2E,6E,10E)-geranylgeranyl diphosphate = 15-cis-phytoene + 2 diphosphate","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:34475"},{"database":"ChEBI","id":"CHEBI:27787"},{"database":"ChEBI","id":"CHEBI:33019"},{"database":"ChEBI","id":"CHEBI:58756"}],"ecNumber":"2.5.1.32","evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00095792"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:34476"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00095792"}]}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00006251"}],"value":"Belongs to the phytoene/squalene synthase family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Non-terminal residue","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":1,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AIU48694.1"}]},{"type":"Non-terminal residue","location":{"start":{"value":330,"modifier":"EXACT"},"end":{"value":330,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AIU48694.1"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022746"}],"id":"KW-0125","category":"Biological process","name":"Carotenoid biosynthesis"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023229"}],"id":"KW-0414","category":"Biological process","name":"Isoprene biosynthesis"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022679"}],"id":"KW-0808","category":"Molecular function","name":"Transferase"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022946"}],"id":"KW-0809","category":"Domain","name":"Transit peptide"}],"references":[{"referenceNumber":1,"citation":{"id":"25249442","citationType":"journal article","authors":["Zeng L.","Zhang Q.","Sun R.","Kong H.","Zhang N.","Ma H."],"citationCrossReferences":[{"database":"PubMed","id":"25249442"},{"database":"DOI","id":"10.1038/ncomms5956"}],"title":"Resolution of deep angiosperm phylogeny using conserved nuclear genes and estimates of early divergence times.","publicationDate":"2014","journal":"Nat. Commun.","firstPage":"4956","lastPage":"4956","volume":"5"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AIU48694.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"KM398032","properties":[{"key":"ProteinId","value":"AIU48694.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"AlphaFoldDB","id":"A0A097PL13","properties":[{"key":"Description","value":"-"}]},{"database":"GO","id":"GO:0010287","properties":[{"key":"GoTerm","value":"C:plastoglobule"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0046905","properties":[{"key":"GoTerm","value":"F:15-cis-phytoene synthase activity"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-EC"}]},{"database":"GO","id":"GO:0004311","properties":[{"key":"GoTerm","value":"F:geranylgeranyl diphosphate synthase activity"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0051996","properties":[{"key":"GoTerm","value":"F:squalene synthase [NAD(P)H] activity"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0016117","properties":[{"key":"GoTerm","value":"P:carotenoid biosynthetic process"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"CDD","id":"cd00683","properties":[{"key":"EntryName","value":"Trans_IPPS_HH"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.10.600.10:FF:000004","properties":[{"key":"EntryName","value":"Phytoene synthase chloroplastic"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.10.600.10","properties":[{"key":"EntryName","value":"Farnesyl Diphosphate Synthase"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR008949","properties":[{"key":"EntryName","value":"Isoprenoid_synthase_dom_sf"}]},{"database":"InterPro","id":"IPR002060","properties":[{"key":"EntryName","value":"Squ/phyt_synthse"}]},{"database":"InterPro","id":"IPR019845","properties":[{"key":"EntryName","value":"Squalene/phytoene_synthase_CS"}]},{"database":"InterPro","id":"IPR044843","properties":[{"key":"EntryName","value":"Trans_IPPS_bact-type"}]},{"database":"InterPro","id":"IPR033904","properties":[{"key":"EntryName","value":"Trans_IPPS_HH"}]},{"database":"PANTHER","id":"PTHR31480","properties":[{"key":"EntryName","value":"BIFUNCTIONAL LYCOPENE CYCLASE/PHYTOENE SYNTHASE"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00494","properties":[{"key":"EntryName","value":"SQS_PSY"},{"key":"MatchStatus","value":"1"}]},{"database":"SFLD","id":"SFLDS00005","properties":[{"key":"EntryName","value":"Isoprenoid_Synthase_Type_I"},{"key":"MatchStatus","value":"1"}]},{"database":"SFLD","id":"SFLDG01212","properties":[{"key":"EntryName","value":"Phytoene_synthase_like"},{"key":"MatchStatus","value":"1"}]},{"database":"SFLD","id":"SFLDG01018","properties":[{"key":"EntryName","value":"Squalene/Phytoene_Synthase_Lik"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF48576","properties":[{"key":"EntryName","value":"Terpenoid synthases"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS01044","properties":[{"key":"EntryName","value":"SQUALEN_PHYTOEN_SYN_1"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS01045","properties":[{"key":"EntryName","value":"SQUALEN_PHYTOEN_SYN_2"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"AGPVGEVVISSEQKVYDVVVKQAALVKELTRGLDKPELVVPGSMMRDAYGRCGEVCAEYAKTFYLGTLLMTPEKRRAIWAIYVWCRRTDELVDGPNASHITPSALDRWEARLEDLFAGRPYDMLDAALSDTVLKFPVDIQPFKDMIEGMRMDLRKSRYKNFDELYLYCYYVAGTVGLMSVPVMGIAPESRASTESVYNGALALGIANQLTNILRDVGEDARRGRIYLPLDELAQYGLSEDDIFRGKVTDKWRSFMKNQIKRARMFFSEAEKGVTELSQASRWPVWASLLLYSQILDEIEANDYNNFTKRAYVSKMKKLMSLPMAYGKSLL","length":330,"molWeight":37452,"crc64":"A214233EEA265A2C","md5":"260C1079230931203072B46BBF27F5CF"},"extraAttributes":{"countByCommentType":{"CATALYTIC ACTIVITY":3,"SIMILARITY":1},"countByFeatureType":{"Non-terminal residue":2},"uniParcId":"UPI00052A6890"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0A097PLX1","uniProtkbId":"A0A097PLX1_9LILI","entryAudit":{"firstPublicDate":"2015-01-07","lastAnnotationUpdateDate":"2026-11-04","lastSequenceUpdateDate":"2015-01-07","entryVersion":33,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Lilium brownii","commonName":"Hong Kong lily","taxonId":82312,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AIU49023.1"}],"lineage":["Eukaryota","Viridiplantae","Streptophyta","Embryophyta","Tracheophyta","Spermatophyta","Magnoliopsida","Liliopsida","Liliales","Liliaceae","Lilium"]},"proteinExistence":"2: Evidence at transcript level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00012552"}],"value":"RNA helicase"},"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00012552"}],"value":"3.6.4.13"}]},"flag":"Fragment"},"features":[{"type":"Domain","location":{"start":{"value":55,"modifier":"EXACT"},"end":{"value":231,"modifier":"EXACT"}},"description":"Helicase ATP-binding","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS51192"}]},{"type":"Domain","location":{"start":{"value":263,"modifier":"EXACT"},"end":{"value":412,"modifier":"EXACT"}},"description":"Helicase C-terminal","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS51194"}]},{"type":"Region","location":{"start":{"value":401,"modifier":"EXACT"},"end":{"value":420,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Motif","location":{"start":{"value":21,"modifier":"EXACT"},"end":{"value":50,"modifier":"EXACT"}},"description":"Q motif","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00552"}]},{"type":"Compositional bias","location":{"start":{"value":401,"modifier":"EXACT"},"end":{"value":420,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Non-terminal residue","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":1,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AIU49023.1"}]},{"type":"Non-terminal residue","location":{"start":{"value":420,"modifier":"EXACT"},"end":{"value":420,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AIU49023.1"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022840"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00541"}],"id":"KW-0067","category":"Ligand","name":"ATP-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022806"}],"id":"KW-0347","category":"Molecular function","name":"Helicase"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022801"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00541"}],"id":"KW-0378","category":"Molecular function","name":"Hydrolase"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022741"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00541"}],"id":"KW-0547","category":"Ligand","name":"Nucleotide-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022884"}],"id":"KW-0694","category":"Molecular function","name":"RNA-binding"}],"references":[{"referenceNumber":1,"citation":{"id":"25249442","citationType":"journal article","authors":["Zeng L.","Zhang Q.","Sun R.","Kong H.","Zhang N.","Ma H."],"citationCrossReferences":[{"database":"PubMed","id":"25249442"},{"database":"DOI","id":"10.1038/ncomms5956"}],"title":"Resolution of deep angiosperm phylogeny using conserved nuclear genes and estimates of early divergence times.","publicationDate":"2014","journal":"Nat. Commun.","firstPage":"4956","lastPage":"4956","volume":"5"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AIU49023.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"KM398362","properties":[{"key":"ProteinId","value":"AIU49023.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"AlphaFoldDB","id":"A0A097PLX1","properties":[{"key":"Description","value":"-"}]},{"database":"GO","id":"GO:0005524","properties":[{"key":"GoTerm","value":"F:ATP binding"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniRule"}]},{"database":"GO","id":"GO:0016787","properties":[{"key":"GoTerm","value":"F:hydrolase activity"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniRule"}]},{"database":"GO","id":"GO:0003676","properties":[{"key":"GoTerm","value":"F:nucleic acid binding"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0003724","properties":[{"key":"GoTerm","value":"F:RNA helicase activity"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-EC"}]},{"database":"CDD","id":"cd17963","properties":[{"key":"EntryName","value":"DEADc_DDX19_DDX25"},{"key":"MatchStatus","value":"1"}]},{"database":"CDD","id":"cd18787","properties":[{"key":"EntryName","value":"SF2_C_DEAD"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.40.50.300","properties":[{"key":"EntryName","value":"P-loop containing nucleotide triphosphate hydrolases"},{"key":"MatchStatus","value":"2"}]},{"database":"InterPro","id":"IPR011545","properties":[{"key":"EntryName","value":"DEAD/DEAH_box_helicase_dom"}]},{"database":"InterPro","id":"IPR014001","properties":[{"key":"EntryName","value":"Helicase_ATP-bd"}]},{"database":"InterPro","id":"IPR001650","properties":[{"key":"EntryName","value":"Helicase_C-like"}]},{"database":"InterPro","id":"IPR027417","properties":[{"key":"EntryName","value":"P-loop_NTPase"}]},{"database":"InterPro","id":"IPR014014","properties":[{"key":"EntryName","value":"RNA_helicase_DEAD_Q_motif"}]},{"database":"PANTHER","id":"PTHR47958","properties":[{"key":"EntryName","value":"ATP-DEPENDENT RNA HELICASE DBP3"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00270","properties":[{"key":"EntryName","value":"DEAD"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00271","properties":[{"key":"EntryName","value":"Helicase_C"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00487","properties":[{"key":"EntryName","value":"DEXDc"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00490","properties":[{"key":"EntryName","value":"HELICc"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF52540","properties":[{"key":"EntryName","value":"P-loop containing nucleoside triphosphate hydrolases"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS51192","properties":[{"key":"EntryName","value":"HELICASE_ATP_BIND_1"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS51194","properties":[{"key":"EntryName","value":"HELICASE_CTER"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS51195","properties":[{"key":"EntryName","value":"Q_MOTIF"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"LEDPDDSDIQVTGDNVYSSASTFEDLSLSKELIQGLYVEMRFKSPSKIQAVTLPMILTPPYKDLVAQAHNGSGKTTCFVLGMLSRVDPSKKIPQAICICPTRELAQQNLEVLKKMGKFTGITAVCAIPSDSAHYTPVKRMPPVTDQVVIGTPGTVKRWMSEKKLAMREVKILVFDEADHMLAEDGFKDDSDRIMREIRRSSNRCQVLLFSATFNETVKAFVSKVITEGNQIFVKKEDLSLDKVKQYKVFCPDELAKLEVIKTKIFEFGEKVGQTIIFVRTRNSASMLHKTLKNEGYECTSIQGTLRQEDREQVIREFKDGYTKVLITTDILARGFDQAQVNLVINFDLPVKHNTEPDYETYLHRIGRAGRFGRKGAAFNMMSSDWDRKIVEKIEDNFKHPIPEVGDSEKDFESALKDAGL","length":420,"molWeight":47453,"crc64":"B6D0593BFA26B2CD","md5":"9183BB538DB7C6BD50BAE7E60CFCC81C"},"extraAttributes":{"countByFeatureType":{"Domain":2,"Region":1,"Motif":1,"Compositional bias":1,"Non-terminal residue":2},"uniParcId":"UPI00052AF8D2"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0A097PM75","uniProtkbId":"A0A097PM75_9LILI","entryAudit":{"firstPublicDate":"2015-01-07","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2015-01-07","entryVersion":34,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Lilium brownii","commonName":"Hong Kong lily","taxonId":82312,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AIU49132.1"}],"lineage":["Eukaryota","Viridiplantae","Streptophyta","Embryophyta","Tracheophyta","Spermatophyta","Magnoliopsida","Liliopsida","Liliales","Liliaceae","Lilium"]},"proteinExistence":"2: Evidence at transcript level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00021915"}],"value":"2-(3-amino-3-carboxypropyl)histidine synthase subunit 1"},"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00012221"}],"value":"2.5.1.108"}]},"alternativeNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00032574"}],"value":"Diphthamide biosynthesis protein 1"}},{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00032789"}],"value":"Diphtheria toxin resistance protein 1"}},{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00031690"}],"value":"S-adenosyl-L-methionine:L-histidine 3-amino-3-carboxypropyltransferase 1"}}],"flag":"Fragment"},"comments":[{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"L-histidyl-[translation elongation factor 2] + S-adenosyl-L-methionine = 2-[(3S)-amino-3-carboxypropyl]-L-histidyl-[translation elongation factor 2] + S-methyl-5'-thioadenosine + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:36783"},{"database":"Rhea","id":"RHEA-COMP:9748"},{"database":"Rhea","id":"RHEA-COMP:9749"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:17509"},{"database":"ChEBI","id":"CHEBI:29979"},{"database":"ChEBI","id":"CHEBI:59789"},{"database":"ChEBI","id":"CHEBI:73995"}],"ecNumber":"2.5.1.108","evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00048403"}]}},{"commentType":"COFACTOR","cofactors":[{"name":"[4Fe-4S] cluster","evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00001966"}],"cofactorCrossReference":{"database":"ChEBI","id":"CHEBI:49883"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00005156"}],"value":"Protein modification; peptidyl-diphthamide biosynthesis"}],"commentType":"PATHWAY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00010173"}],"value":"Belongs to the DPH1/DPH2 family. DPH1 subfamily"}],"commentType":"SIMILARITY"}],"features":[{"type":"Non-terminal residue","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":1,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AIU49132.1"}]},{"type":"Non-terminal residue","location":{"start":{"value":233,"modifier":"EXACT"},"end":{"value":233,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AIU49132.1"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023004"}],"id":"KW-0408","category":"Ligand","name":"Iron"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023014"}],"id":"KW-0411","category":"Ligand","name":"Iron-sulfur"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022723"}],"id":"KW-0479","category":"Ligand","name":"Metal-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022691"}],"id":"KW-0949","category":"Ligand","name":"S-adenosyl-L-methionine"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022679"}],"id":"KW-0808","category":"Molecular function","name":"Transferase"}],"references":[{"referenceNumber":1,"citation":{"id":"25249442","citationType":"journal article","authors":["Zeng L.","Zhang Q.","Sun R.","Kong H.","Zhang N.","Ma H."],"citationCrossReferences":[{"database":"PubMed","id":"25249442"},{"database":"DOI","id":"10.1038/ncomms5956"}],"title":"Resolution of deep angiosperm phylogeny using conserved nuclear genes and estimates of early divergence times.","publicationDate":"2014","journal":"Nat. Commun.","firstPage":"4956","lastPage":"4956","volume":"5"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AIU49132.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"KM398472","properties":[{"key":"ProteinId","value":"AIU49132.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"AlphaFoldDB","id":"A0A097PM75","properties":[{"key":"Description","value":"-"}]},{"database":"UniPathway","id":"UPA00559","properties":[{"key":"RectionId","value":"-"}]},{"database":"GO","id":"GO:0090560","properties":[{"key":"GoTerm","value":"F:2-(3-amino-3-carboxypropyl)histidine synthase activity"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-EC"}]},{"database":"GO","id":"GO:0017183","properties":[{"key":"GoTerm","value":"P:protein histidyl modification to diphthamide"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniPathway"}]},{"database":"FunFam","id":"3.40.50.11840:FF:000001","properties":[{"key":"EntryName","value":"2-(3-amino-3-carboxypropyl)histidine synthase subunit 1"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.40.50.11840","properties":[{"key":"EntryName","value":"Diphthamide synthesis DPH1/DPH2 domain 1"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.40.50.11850","properties":[{"key":"EntryName","value":"Diphthamide synthesis DPH1/DPH2 domain 2"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.40.50.11860","properties":[{"key":"EntryName","value":"Diphthamide synthesis DPH1/DPH2 domain 3"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR016435","properties":[{"key":"EntryName","value":"DPH1/DPH2"}]},{"database":"InterPro","id":"IPR042263","properties":[{"key":"EntryName","value":"DPH1/DPH2_1"}]},{"database":"InterPro","id":"IPR042264","properties":[{"key":"EntryName","value":"DPH1/DPH2_2"}]},{"database":"InterPro","id":"IPR042265","properties":[{"key":"EntryName","value":"DPH1/DPH2_3"}]},{"database":"InterPro","id":"IPR035435","properties":[{"key":"EntryName","value":"DPH1/DPH2_euk_archaea"}]},{"database":"NCBIfam","id":"TIGR00322","properties":[{"key":"EntryName","value":"diphth2_R"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR10762:SF1","properties":[{"key":"EntryName","value":"2-(3-AMINO-3-CARBOXYPROPYL)HISTIDINE SYNTHASE SUBUNIT 1"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR10762","properties":[{"key":"EntryName","value":"DIPHTHAMIDE BIOSYNTHESIS PROTEIN"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF01866","properties":[{"key":"EntryName","value":"Diphthamide_syn"},{"key":"MatchStatus","value":"1"}]},{"database":"PIRSF","id":"PIRSF004967","properties":[{"key":"EntryName","value":"DPH1"},{"key":"MatchStatus","value":"1"}]},{"database":"SFLD","id":"SFLDS00032","properties":[{"key":"EntryName","value":"Radical_SAM_3-amino-3-carboxyp"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"PKRFIKSIPASLLSDPALNAAISLLPANYNFEIHKTIHRLRSASARRVALQFPDGLLMFALPIADILRSFVLAEPTYGACCLDDYAASALSADLLVHYGHSCLVPVPSSLIPSLYVFVEITIDPARLVAAVCSALALAGTVQFLSAVHAARSLLVIVPQAKPLSAGEVLGCTAPTLLIFVADGRFHLEAFMIANPGIRAFRYDPYLGVLILEQYDHEGMMRARREAIVKAREA","length":233,"molWeight":25209,"crc64":"A76B2E29C4AD6F5B","md5":"B072CFA3FCBF00221792510DC260D8C6"},"extraAttributes":{"countByCommentType":{"CATALYTIC ACTIVITY":1,"COFACTOR":1,"PATHWAY":1,"SIMILARITY":1},"countByFeatureType":{"Non-terminal residue":2},"uniParcId":"UPI00052A3D5F"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0A097PMN4","uniProtkbId":"A0A097PMN4_9LILI","entryAudit":{"firstPublicDate":"2015-01-07","lastAnnotationUpdateDate":"2026-01-28","lastSequenceUpdateDate":"2015-01-07","entryVersion":24,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Lilium brownii","commonName":"Hong Kong lily","taxonId":82312,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AIU49286.1"}],"lineage":["Eukaryota","Viridiplantae","Streptophyta","Embryophyta","Tracheophyta","Spermatophyta","Magnoliopsida","Liliopsida","Liliales","Liliaceae","Lilium"]},"proteinExistence":"2: Evidence at transcript level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00020264"}],"value":"Elongator complex protein 5"}},"flag":"Fragment"},"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00005043"}],"value":"tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis"}],"commentType":"PATHWAY"},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004496"}],"value":"Cytoplasm","id":"SL-0086"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004123"}],"value":"Nucleus","id":"SL-0191"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00009567"}],"value":"Belongs to the ELP5 family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Region","location":{"start":{"value":202,"modifier":"EXACT"},"end":{"value":228,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":202,"modifier":"EXACT"},"end":{"value":212,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":213,"modifier":"EXACT"},"end":{"value":228,"modifier":"EXACT"}},"description":"Acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Non-terminal residue","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":1,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AIU49286.1"}]},{"type":"Non-terminal residue","location":{"start":{"value":228,"modifier":"EXACT"},"end":{"value":228,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AIU49286.1"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022490"}],"id":"KW-0963","category":"Cellular component","name":"Cytoplasm"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023242"}],"id":"KW-0539","category":"Cellular component","name":"Nucleus"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022694"}],"id":"KW-0819","category":"Biological process","name":"tRNA processing"}],"references":[{"referenceNumber":1,"citation":{"id":"25249442","citationType":"journal article","authors":["Zeng L.","Zhang Q.","Sun R.","Kong H.","Zhang N.","Ma H."],"citationCrossReferences":[{"database":"PubMed","id":"25249442"},{"database":"DOI","id":"10.1038/ncomms5956"}],"title":"Resolution of deep angiosperm phylogeny using conserved nuclear genes and estimates of early divergence times.","publicationDate":"2014","journal":"Nat. Commun.","firstPage":"4956","lastPage":"4956","volume":"5"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AIU49286.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"KM398629","properties":[{"key":"ProteinId","value":"AIU49286.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"AlphaFoldDB","id":"A0A097PMN4","properties":[{"key":"Description","value":"-"}]},{"database":"UniPathway","id":"UPA00988","properties":[{"key":"RectionId","value":"-"}]},{"database":"GO","id":"GO:0005829","properties":[{"key":"GoTerm","value":"C:cytosol"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:0033588","properties":[{"key":"GoTerm","value":"C:elongator holoenzyme complex"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0005634","properties":[{"key":"GoTerm","value":"C:nucleus"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0000049","properties":[{"key":"GoTerm","value":"F:tRNA binding"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:0002098","properties":[{"key":"GoTerm","value":"P:tRNA wobble uridine modification"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"CDD","id":"cd19496","properties":[{"key":"EntryName","value":"Elp5"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR019519","properties":[{"key":"EntryName","value":"Elp5"}]},{"database":"PANTHER","id":"PTHR15641","properties":[{"key":"EntryName","value":"ELONGATOR COMPLEX PROTEIN 5"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR15641:SF1","properties":[{"key":"EntryName","value":"ELONGATOR COMPLEX PROTEIN 5"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF10483","properties":[{"key":"EntryName","value":"Elong_Iki1"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"KILDCYSDPLGWIRQTKDVRDTDKVLSSVIDLGRGFLGQGKERFAVAIDSVSDMLRYTSLSAVASLINNLRSHVQVSCMFWLLHSDLHESRASSVFEYISTIIASLEPENLFWLAQNSHRGKFNVRLKRRNGRVKITHEEFHMEQIGIKFVNHNLLPKVQFNLQLSEKERADRANVILPFEHQGNGESILIYDGRQSLSEGKGEIHYIRDSDDEHPDSDEDPDDDLEI","length":228,"molWeight":26149,"crc64":"C5E139292F7DADEB","md5":"000A9901AD4CB67A98D2D25A0107A0C9"},"extraAttributes":{"countByCommentType":{"PATHWAY":1,"SUBCELLULAR LOCATION":1,"SIMILARITY":1},"countByFeatureType":{"Region":1,"Compositional bias":2,"Non-terminal residue":2},"uniParcId":"UPI00052AE500"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0A097PMU1","uniProtkbId":"A0A097PMU1_9LILI","entryAudit":{"firstPublicDate":"2015-01-07","lastAnnotationUpdateDate":"2026-01-28","lastSequenceUpdateDate":"2015-01-07","entryVersion":15,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Lilium brownii","commonName":"Hong Kong lily","taxonId":82312,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AIU49341.1"}],"lineage":["Eukaryota","Viridiplantae","Streptophyta","Embryophyta","Tracheophyta","Spermatophyta","Magnoliopsida","Liliopsida","Liliales","Liliaceae","Lilium"]},"proteinExistence":"2: Evidence at transcript level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00012083"}],"value":"glucose-6-phosphate 1-epimerase"},"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00012083"}],"value":"5.1.3.15"}]},"flag":"Fragment"},"comments":[{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"alpha-D-glucose 6-phosphate = beta-D-glucose 6-phosphate","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:16249"},{"database":"ChEBI","id":"CHEBI:58225"},{"database":"ChEBI","id":"CHEBI:58247"}],"ecNumber":"5.1.3.15","evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00001096"}]}},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00005866"}],"value":"Belongs to the glucose-6-phosphate 1-epimerase family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Non-terminal residue","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":1,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AIU49341.1"}]},{"type":"Non-terminal residue","location":{"start":{"value":214,"modifier":"EXACT"},"end":{"value":214,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AIU49341.1"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023235"}],"id":"KW-0413","category":"Molecular function","name":"Isomerase"}],"references":[{"referenceNumber":1,"citation":{"id":"25249442","citationType":"journal article","authors":["Zeng L.","Zhang Q.","Sun R.","Kong H.","Zhang N.","Ma H."],"citationCrossReferences":[{"database":"PubMed","id":"25249442"},{"database":"DOI","id":"10.1038/ncomms5956"}],"title":"Resolution of deep angiosperm phylogeny using conserved nuclear genes and estimates of early divergence times.","publicationDate":"2014","journal":"Nat. Commun.","firstPage":"4956","lastPage":"4956","volume":"5"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AIU49341.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"KM398684","properties":[{"key":"ProteinId","value":"AIU49341.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"AlphaFoldDB","id":"A0A097PMU1","properties":[{"key":"Description","value":"-"}]},{"database":"GO","id":"GO:0005737","properties":[{"key":"GoTerm","value":"C:cytoplasm"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:0030246","properties":[{"key":"GoTerm","value":"F:carbohydrate binding"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0047938","properties":[{"key":"GoTerm","value":"F:glucose-6-phosphate 1-epimerase activity"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-EC"}]},{"database":"GO","id":"GO:0005975","properties":[{"key":"GoTerm","value":"P:carbohydrate metabolic process"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"CDD","id":"cd09020","properties":[{"key":"EntryName","value":"D-hex-6-P-epi_like"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.70.98.10","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR008183","properties":[{"key":"EntryName","value":"Aldose_1/G6P_1-epimerase"}]},{"database":"InterPro","id":"IPR025532","properties":[{"key":"EntryName","value":"G6P_1-epimerase"}]},{"database":"InterPro","id":"IPR011013","properties":[{"key":"EntryName","value":"Gal_mutarotase_sf_dom"}]},{"database":"InterPro","id":"IPR014718","properties":[{"key":"EntryName","value":"GH-type_carb-bd"}]},{"database":"PANTHER","id":"PTHR11122","properties":[{"key":"EntryName","value":"APOSPORY-ASSOCIATED PROTEIN C-RELATED"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR11122:SF39","properties":[{"key":"EntryName","value":"GLUCOSE-6-PHOSPHATE 1-EPIMERASE"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF01263","properties":[{"key":"EntryName","value":"Aldose_epim"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF74650","properties":[{"key":"EntryName","value":"Galactose mutarotase-like"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"VEGNGGLPKVSLSSVHGSEAEIYLFGGCITSWKVPNRDLLFVRPDAVFNGKKPISGGVPHCFPQFGPGPIQQHGFARNSNWSITDSESIDGDPIVTLELKDSPYSRSMWDFSFNALYKITLGSSSLSTVLTITNSDTKPFSFSTALHTYFRASVTGATVKGLKGCKTLNKDPDPTNPLEGVEEREVITFPGFVDCVYLDAPQELQLDNGLGDIV","length":214,"molWeight":23163,"crc64":"F8D93395C75BA0A5","md5":"29C1A7E074ACE35AAA879F3713F297EA"},"extraAttributes":{"countByCommentType":{"CATALYTIC ACTIVITY":1,"SIMILARITY":1},"countByFeatureType":{"Non-terminal residue":2},"uniParcId":"UPI00052AF9D1"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0A097PMZ4","uniProtkbId":"A0A097PMZ4_9LILI","entryAudit":{"firstPublicDate":"2015-01-07","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2015-01-07","entryVersion":35,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Lilium brownii","commonName":"Hong Kong lily","taxonId":82312,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AIU49398.1"}],"lineage":["Eukaryota","Viridiplantae","Streptophyta","Embryophyta","Tracheophyta","Spermatophyta","Magnoliopsida","Liliopsida","Liliales","Liliaceae","Lilium"]},"proteinExistence":"2: Evidence at transcript level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00044200"}],"value":"Translation initiation factor IF-2, mitochondrial"}},"flag":"Fragment"},"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00096070"}],"value":"Mitochondrial translation initiation factor that promotes binding of formylmethionyl-tRNA to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex"}],"commentType":"FUNCTION"},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004173"}],"value":"Mitochondrion","id":"SL-0173"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00007733"}],"value":"Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily"}],"commentType":"SIMILARITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU01059"}],"value":"Lacks conserved residue(s) required for the propagation of feature annotation"}],"commentType":"CAUTION"}],"features":[{"type":"Domain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":143,"modifier":"EXACT"}},"description":"Tr-type G","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS51722"}]},{"type":"Non-terminal residue","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":1,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AIU49398.1"}]},{"type":"Non-terminal residue","location":{"start":{"value":365,"modifier":"EXACT"},"end":{"value":365,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AIU49398.1"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023134"}],"id":"KW-0342","category":"Ligand","name":"GTP-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022540"},{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AIU49398.1"}],"id":"KW-0396","category":"Molecular function","name":"Initiation factor"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023128"}],"id":"KW-0496","category":"Cellular component","name":"Mitochondrion"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022741"}],"id":"KW-0547","category":"Ligand","name":"Nucleotide-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022917"}],"id":"KW-0648","category":"Biological process","name":"Protein biosynthesis"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022946"}],"id":"KW-0809","category":"Domain","name":"Transit peptide"}],"references":[{"referenceNumber":1,"citation":{"id":"25249442","citationType":"journal article","authors":["Zeng L.","Zhang Q.","Sun R.","Kong H.","Zhang N.","Ma H."],"citationCrossReferences":[{"database":"PubMed","id":"25249442"},{"database":"DOI","id":"10.1038/ncomms5956"}],"title":"Resolution of deep angiosperm phylogeny using conserved nuclear genes and estimates of early divergence times.","publicationDate":"2014","journal":"Nat. Commun.","firstPage":"4956","lastPage":"4956","volume":"5"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AIU49398.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"KM398741","properties":[{"key":"ProteinId","value":"AIU49398.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"AlphaFoldDB","id":"A0A097PMZ4","properties":[{"key":"Description","value":"-"}]},{"database":"GO","id":"GO:0005739","properties":[{"key":"GoTerm","value":"C:mitochondrion"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0005525","properties":[{"key":"GoTerm","value":"F:GTP binding"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0003924","properties":[{"key":"GoTerm","value":"F:GTPase activity"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0003743","properties":[{"key":"GoTerm","value":"F:translation initiation factor activity"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"CDD","id":"cd01887","properties":[{"key":"EntryName","value":"IF2_eIF5B"},{"key":"MatchStatus","value":"1"}]},{"database":"CDD","id":"cd03702","properties":[{"key":"EntryName","value":"IF2_mtIF2_II"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.40.50.10050:FF:000001","properties":[{"key":"EntryName","value":"Translation initiation factor IF-2"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.40.50.300:FF:000019","properties":[{"key":"EntryName","value":"Translation initiation factor IF-2"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.40.50.300","properties":[{"key":"EntryName","value":"P-loop containing nucleotide triphosphate hydrolases"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.40.30.10","properties":[{"key":"EntryName","value":"Translation factors"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.40.50.10050","properties":[{"key":"EntryName","value":"Translation initiation factor IF- 2, domain 3"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR053905","properties":[{"key":"EntryName","value":"EF-G-like_DII"}]},{"database":"InterPro","id":"IPR044145","properties":[{"key":"EntryName","value":"IF2_II"}]},{"database":"InterPro","id":"IPR027417","properties":[{"key":"EntryName","value":"P-loop_NTPase"}]},{"database":"InterPro","id":"IPR005225","properties":[{"key":"EntryName","value":"Small_GTP-bd"}]},{"database":"InterPro","id":"IPR000795","properties":[{"key":"EntryName","value":"T_Tr_GTP-bd_dom"}]},{"database":"InterPro","id":"IPR000178","properties":[{"key":"EntryName","value":"TF_IF2_bacterial-like"}]},{"database":"InterPro","id":"IPR015760","properties":[{"key":"EntryName","value":"TIF_IF2"}]},{"database":"InterPro","id":"IPR023115","properties":[{"key":"EntryName","value":"TIF_IF2_dom3"}]},{"database":"InterPro","id":"IPR036925","properties":[{"key":"EntryName","value":"TIF_IF2_dom3_sf"}]},{"database":"InterPro","id":"IPR009000","properties":[{"key":"EntryName","value":"Transl_B-barrel_sf"}]},{"database":"NCBIfam","id":"TIGR00487","properties":[{"key":"EntryName","value":"IF-2"},{"key":"MatchStatus","value":"1"}]},{"database":"NCBIfam","id":"TIGR00231","properties":[{"key":"EntryName","value":"small_GTP"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR43381:SF20","properties":[{"key":"EntryName","value":"TRANSLATION INITIATION FACTOR IF-2, MITOCHONDRIAL"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR43381","properties":[{"key":"EntryName","value":"TRANSLATION INITIATION FACTOR IF-2-RELATED"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF22042","properties":[{"key":"EntryName","value":"EF-G_D2"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00009","properties":[{"key":"EntryName","value":"GTP_EFTU"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF11987","properties":[{"key":"EntryName","value":"IF-2"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF52156","properties":[{"key":"EntryName","value":"Initiation factor IF2/eIF5b, domain 3"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF52540","properties":[{"key":"EntryName","value":"P-loop containing nucleoside triphosphate hydrolases"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF50447","properties":[{"key":"EntryName","value":"Translation proteins"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS51722","properties":[{"key":"EntryName","value":"G_TR_2"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"AAREAGGITQHLGAFVVSMPSGASITFLDTPGHAAFSAMRARGAAITDIVVLVVAADDGVMPQTLEAMAHAKAANVPIVVAINKCDKPAADPERVRIQLGSEGLLLEDLGGDVQVVEVSAISKTGLDKLEEALLLQAEMMDLKARIDGPAQAFVVEARLDRGRGPLATAIVKAGTLLSGQHIVVGAEWGKIRAIRDTTGKVSELASPAMPVEIEGIKGLPMAGDDVVVVESEERARMLSSGRKKKFEKDRLHKVSGEGFDISDTSEEAPERVELPIIVKADVQGTVQAVTDALRSLNSSQVFVNIVHVGVGAISHSDIDLAQACGACIVGFNIRNHPSDIALAAKQANIKICLHKVIYHLLEEMG","length":365,"molWeight":38426,"crc64":"578F6FDF26F93842","md5":"43C0CA8B0FA0CA178FF0C764BAD99457"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"SUBCELLULAR LOCATION":1,"SIMILARITY":1,"CAUTION":1},"countByFeatureType":{"Domain":1,"Non-terminal residue":2},"uniParcId":"UPI00052AA0B3"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0A097PQ74","uniProtkbId":"A0A097PQ74_9LILI","entryAudit":{"firstPublicDate":"2015-01-07","lastAnnotationUpdateDate":"2026-11-04","lastSequenceUpdateDate":"2015-01-07","entryVersion":35,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Lilium brownii","commonName":"Hong Kong lily","taxonId":82312,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AIU50151.1"}],"lineage":["Eukaryota","Viridiplantae","Streptophyta","Embryophyta","Tracheophyta","Spermatophyta","Magnoliopsida","Liliopsida","Liliales","Liliaceae","Lilium"]},"proteinExistence":"2: Evidence at transcript level","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AIU50151.1"}],"value":"Aspartyl protease family protein"}}],"flag":"Fragment"},"comments":[{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"Preferential cleavage: hydrophobic, preferably aromatic, residues in P1 and P1' positions. Cleaves 1-Phe-|-Val-2, 4-Gln-|-His-5, 13-Glu-|-Ala-14, 14-Ala-|-Leu-15, 15-Leu-|-Tyr-16, 16-Tyr-|-Leu-17, 23-Gly-|-Phe-24, 24-Phe-|-Phe-25 and 25-Phe-|-Tyr-26 bonds in the B chain of insulin.","ecNumber":"3.4.23.1","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU10094"}]}},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004193"}],"value":"Cell membrane","id":"SL-0039"},"topology":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004193"}],"value":"Lipid-anchor","id":"SL-9901"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00007447"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU01103"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000454"}],"value":"Belongs to the peptidase A1 family"}],"commentType":"SIMILARITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU01103"}],"value":"Lacks conserved residue(s) required for the propagation of feature annotation"}],"commentType":"CAUTION"}],"features":[{"type":"Domain","location":{"start":{"value":58,"modifier":"EXACT"},"end":{"value":378,"modifier":"EXACT"}},"description":"Peptidase A1","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS51767"}]},{"type":"Region","location":{"start":{"value":388,"modifier":"EXACT"},"end":{"value":412,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":391,"modifier":"EXACT"},"end":{"value":402,"modifier":"EXACT"}},"description":"Pro residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":403,"modifier":"EXACT"},"end":{"value":412,"modifier":"EXACT"}},"description":"Polar residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Active site","location":{"start":{"value":76,"modifier":"EXACT"},"end":{"value":76,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR601461-1"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU10094"}]},{"type":"Active site","location":{"start":{"value":263,"modifier":"EXACT"},"end":{"value":263,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR601461-1"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU10094"}]},{"type":"Non-terminal residue","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":1,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AIU50151.1"}]},{"type":"Non-terminal residue","location":{"start":{"value":412,"modifier":"EXACT"},"end":{"value":412,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AIU50151.1"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022750"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU01103"}],"id":"KW-0064","category":"Molecular function","name":"Aspartyl protease"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022475"}],"id":"KW-1003","category":"Cellular component","name":"Cell membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023180"}],"id":"KW-0325","category":"PTM","name":"Glycoprotein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022801"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU01103"}],"id":"KW-0378","category":"Molecular function","name":"Hydrolase"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023288"}],"id":"KW-0449","category":"PTM","name":"Lipoprotein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023136"}],"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022670"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU01103"}],"id":"KW-0645","category":"Molecular function","name":"Protease"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022729"}],"id":"KW-0732","category":"Domain","name":"Signal"}],"references":[{"referenceNumber":1,"citation":{"id":"25249442","citationType":"journal article","authors":["Zeng L.","Zhang Q.","Sun R.","Kong H.","Zhang N.","Ma H."],"citationCrossReferences":[{"database":"PubMed","id":"25249442"},{"database":"DOI","id":"10.1038/ncomms5956"}],"title":"Resolution of deep angiosperm phylogeny using conserved nuclear genes and estimates of early divergence times.","publicationDate":"2014","journal":"Nat. Commun.","firstPage":"4956","lastPage":"4956","volume":"5"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AIU50151.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"KM399499","properties":[{"key":"ProteinId","value":"AIU50151.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"AlphaFoldDB","id":"A0A097PQ74","properties":[{"key":"Description","value":"-"}]},{"database":"GO","id":"GO:0005886","properties":[{"key":"GoTerm","value":"C:plasma membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0004190","properties":[{"key":"GoTerm","value":"F:aspartic-type endopeptidase activity"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniRule"}]},{"database":"GO","id":"GO:0006508","properties":[{"key":"GoTerm","value":"P:proteolysis"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"FunFam","id":"2.40.70.10:FF:000012","properties":[{"key":"EntryName","value":"Aspartyl protease family protein 1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.40.70.10:FF:000014","properties":[{"key":"EntryName","value":"Aspartyl protease family protein 1"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.40.70.10","properties":[{"key":"EntryName","value":"Acid Proteases"},{"key":"MatchStatus","value":"2"}]},{"database":"InterPro","id":"IPR001461","properties":[{"key":"EntryName","value":"Aspartic_peptidase_A1"}]},{"database":"InterPro","id":"IPR001969","properties":[{"key":"EntryName","value":"Aspartic_peptidase_AS"}]},{"database":"InterPro","id":"IPR033121","properties":[{"key":"EntryName","value":"PEPTIDASE_A1"}]},{"database":"InterPro","id":"IPR021109","properties":[{"key":"EntryName","value":"Peptidase_aspartic_dom_sf"}]},{"database":"InterPro","id":"IPR032799","properties":[{"key":"EntryName","value":"TAXi_C"}]},{"database":"InterPro","id":"IPR032861","properties":[{"key":"EntryName","value":"TAXi_N"}]},{"database":"PANTHER","id":"PTHR13683","properties":[{"key":"EntryName","value":"ASPARTYL PROTEASES"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR13683:SF232","properties":[{"key":"EntryName","value":"OS09G0542100 PROTEIN"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF14541","properties":[{"key":"EntryName","value":"TAXi_C"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF14543","properties":[{"key":"EntryName","value":"TAXi_N"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR00792","properties":[{"key":"EntryName","value":"PEPSIN"}]},{"database":"SUPFAM","id":"SSF50630","properties":[{"key":"EntryName","value":"Acid proteases"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00141","properties":[{"key":"EntryName","value":"ASP_PROTEASE"},{"key":"MatchStatus","value":"2"}]},{"database":"PROSITE","id":"PS51767","properties":[{"key":"EntryName","value":"PEPTIDASE_A1"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"LDLHHRFSAPVRRWWPERGTVEYYAALARHDLALRGRALVTFSGGNETLAISSLGFLHYATVMVGTPGLSFLVALDTGSDLFWLPCDCSSCAPEFEFSIYSPSTSVTSQAVLCNSSSCQSKCSRGPYCPYEVAYVSADTSSSGYLVEDVLSLTTEDELVQAPIMFGCGQVQTGSFLDAAAPNGLFGLGMEKLSVPSILASAGLISNSFSMCFGSDGVGRISFGDQGSSDQEQTPFNLKSTYNISVTGVAVGNSITADFSALVDSGTSFTYLADPAYTFISQSFNARVKDKRDPNIPFEYCYHISSNNISRQLPDISLTTKGGGQFPVSDPIVLLTTQQRENVYCLALVKSSNLNIIGQNFMTGLRIVFDRERMVLGWKKFNCDVEESNPLPVNPRNPSPSPTLSPKSYSPEA","length":412,"molWeight":44558,"crc64":"48B2CA5218620D8A","md5":"2629E9A55D76EFE3621E0DC69C2C3911"},"extraAttributes":{"countByCommentType":{"CATALYTIC ACTIVITY":1,"SUBCELLULAR LOCATION":1,"SIMILARITY":1,"CAUTION":1},"countByFeatureType":{"Domain":1,"Region":1,"Compositional bias":2,"Active site":2,"Non-terminal residue":2},"uniParcId":"UPI00052AD81C"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0A097PQL0","uniProtkbId":"A0A097PQL0_9LILI","entryAudit":{"firstPublicDate":"2015-01-07","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2015-01-07","entryVersion":25,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Lilium brownii","commonName":"Hong Kong lily","taxonId":82312,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AIU50345.1"}],"lineage":["Eukaryota","Viridiplantae","Streptophyta","Embryophyta","Tracheophyta","Spermatophyta","Magnoliopsida","Liliopsida","Liliales","Liliaceae","Lilium"]},"proteinExistence":"2: Evidence at transcript level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00013064"}],"value":"protein-tyrosine-phosphatase"},"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00013064"}],"value":"3.1.3.48"}]},"flag":"Fragment"},"comments":[{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:10684"},{"database":"Rhea","id":"RHEA-COMP:10136"},{"database":"Rhea","id":"RHEA-COMP:20101"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:43474"},{"database":"ChEBI","id":"CHEBI:46858"},{"database":"ChEBI","id":"CHEBI:61978"}],"ecNumber":"3.1.3.48","evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00051722"}]}},{"commentType":"COFACTOR","cofactors":[{"name":"Mg(2+)","evidences":[{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR628472-2"}],"cofactorCrossReference":{"database":"ChEBI","id":"CHEBI:18420"}}],"note":{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR628472-2"}],"value":"Binds 1 Mg(2+) ion per subunit."}]}},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00010501"}],"value":"Belongs to the HAD-like hydrolase superfamily. EYA family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Active site","location":{"start":{"value":5,"modifier":"EXACT"},"end":{"value":5,"modifier":"EXACT"}},"description":"Nucleophile","evidences":[{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR628472-1"}]},{"type":"Active site","location":{"start":{"value":7,"modifier":"EXACT"},"end":{"value":7,"modifier":"EXACT"}},"description":"Proton donor","evidences":[{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR628472-1"}]},{"type":"Binding site","location":{"start":{"value":5,"modifier":"EXACT"},"end":{"value":5,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:18420"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR628472-2"}],"ligand":{"name":"Mg(2+)","id":"ChEBI:CHEBI:18420"}},{"type":"Binding site","location":{"start":{"value":7,"modifier":"EXACT"},"end":{"value":7,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:18420"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR628472-2"}],"ligand":{"name":"Mg(2+)","id":"ChEBI:CHEBI:18420"}},{"type":"Binding site","location":{"start":{"value":205,"modifier":"EXACT"},"end":{"value":205,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:18420"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR628472-2"}],"ligand":{"name":"Mg(2+)","id":"ChEBI:CHEBI:18420"}},{"type":"Non-terminal residue","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":1,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AIU50345.1"}]},{"type":"Non-terminal residue","location":{"start":{"value":246,"modifier":"EXACT"},"end":{"value":246,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AIU50345.1"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022801"}],"id":"KW-0378","category":"Molecular function","name":"Hydrolase"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022842"},{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR628472-2"}],"id":"KW-0460","category":"Ligand","name":"Magnesium"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022723"},{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR628472-2"}],"id":"KW-0479","category":"Ligand","name":"Metal-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022912"}],"id":"KW-0904","category":"Molecular function","name":"Protein phosphatase"}],"references":[{"referenceNumber":1,"citation":{"id":"25249442","citationType":"journal article","authors":["Zeng L.","Zhang Q.","Sun R.","Kong H.","Zhang N.","Ma H."],"citationCrossReferences":[{"database":"PubMed","id":"25249442"},{"database":"DOI","id":"10.1038/ncomms5956"}],"title":"Resolution of deep angiosperm phylogeny using conserved nuclear genes and estimates of early divergence times.","publicationDate":"2014","journal":"Nat. Commun.","firstPage":"4956","lastPage":"4956","volume":"5"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AIU50345.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"KM399712","properties":[{"key":"ProteinId","value":"AIU50345.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"AlphaFoldDB","id":"A0A097PQL0","properties":[{"key":"Description","value":"-"}]},{"database":"GO","id":"GO:0005634","properties":[{"key":"GoTerm","value":"C:nucleus"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:0004725","properties":[{"key":"GoTerm","value":"F:protein tyrosine phosphatase activity"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-EC"}]},{"database":"GO","id":"GO:0030154","properties":[{"key":"GoTerm","value":"P:cell differentiation"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:0045739","properties":[{"key":"GoTerm","value":"P:positive regulation of DNA repair"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"Gene3D","id":"3.40.50.12350","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR028472","properties":[{"key":"EntryName","value":"EYA"}]},{"database":"InterPro","id":"IPR006545","properties":[{"key":"EntryName","value":"EYA_dom"}]},{"database":"InterPro","id":"IPR038102","properties":[{"key":"EntryName","value":"EYA_dom_sf"}]},{"database":"NCBIfam","id":"TIGR01658","properties":[{"key":"EntryName","value":"EYA-cons_domain"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR10190:SF16","properties":[{"key":"EntryName","value":"DEVELOPMENTAL PROTEIN EYES ABSENT"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR10190","properties":[{"key":"EntryName","value":"EYES ABSENT"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"VYIWDMDETLILLKSLLDGTYARSYNGLKDSVKGMEIGKCWEDRILQVCDEYFYYEQIEDYNQPFLDALSEYDDGKDLSEYDFNNDGFDYVNKRKLAYRHRVIGQKYAQGLRSVLDQQMLKLWDDLYQLTDGYTEGWLSAGHALLEQPNIHVLVTSGSLVPSLVKCLLFRLDDVIVYSAWEVGKLQCFSWIKNRFPTVRFCVIGDGMEECEAAQKMMWPFIKIDLYPHRFPGLTIRMMEHYMDTIY","length":246,"molWeight":28959,"crc64":"AD849F3AB1173BC9","md5":"6071EA530A30528C507B1C11296D511F"},"extraAttributes":{"countByCommentType":{"CATALYTIC ACTIVITY":1,"COFACTOR":1,"SIMILARITY":1},"countByFeatureType":{"Active site":2,"Binding site":3,"Non-terminal residue":2},"uniParcId":"UPI00052A9945"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0A097PQZ7","uniProtkbId":"A0A097PQZ7_9LILI","entryAudit":{"firstPublicDate":"2015-01-07","lastAnnotationUpdateDate":"2026-11-04","lastSequenceUpdateDate":"2015-01-07","entryVersion":33,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Lilium brownii","commonName":"Hong Kong lily","taxonId":82312,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AIU50455.1"}],"lineage":["Eukaryota","Viridiplantae","Streptophyta","Embryophyta","Tracheophyta","Spermatophyta","Magnoliopsida","Liliopsida","Liliales","Liliaceae","Lilium"]},"proteinExistence":"2: Evidence at transcript level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00070126"}],"value":"General transcription factor IIH subunit 2"}},"flag":"Fragment"},"comments":[{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004123"}],"value":"Nucleus","id":"SL-0191"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00006092"}],"value":"Belongs to the GTF2H2 family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Domain","location":{"start":{"value":359,"modifier":"EXACT"},"end":{"value":379,"modifier":"EXACT"}},"description":"C2H2-type","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS00028"}]},{"type":"Zinc finger","location":{"start":{"value":282,"modifier":"EXACT"},"end":{"value":299,"modifier":"EXACT"}},"description":"C4-type","evidences":[{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR015919-1"}]},{"type":"Non-terminal residue","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":1,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AIU50455.1"}]},{"type":"Non-terminal residue","location":{"start":{"value":388,"modifier":"EXACT"},"end":{"value":388,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AIU50455.1"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022763"}],"id":"KW-0227","category":"Biological process","name":"DNA damage"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023204"}],"id":"KW-0234","category":"Biological process","name":"DNA repair"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022723"}],"id":"KW-0479","category":"Ligand","name":"Metal-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023242"}],"id":"KW-0539","category":"Cellular component","name":"Nucleus"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023163"}],"id":"KW-0804","category":"Biological process","name":"Transcription"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023015"}],"id":"KW-0805","category":"Biological process","name":"Transcription regulation"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022833"}],"id":"KW-0862","category":"Ligand","name":"Zinc"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022771"}],"id":"KW-0863","category":"Domain","name":"Zinc-finger"}],"references":[{"referenceNumber":1,"citation":{"id":"25249442","citationType":"journal article","authors":["Zeng L.","Zhang Q.","Sun R.","Kong H.","Zhang N.","Ma H."],"citationCrossReferences":[{"database":"PubMed","id":"25249442"},{"database":"DOI","id":"10.1038/ncomms5956"}],"title":"Resolution of deep angiosperm phylogeny using conserved nuclear genes and estimates of early divergence times.","publicationDate":"2014","journal":"Nat. Commun.","firstPage":"4956","lastPage":"4956","volume":"5"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AIU50455.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"KM399822","properties":[{"key":"ProteinId","value":"AIU50455.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"AlphaFoldDB","id":"A0A097PQZ7","properties":[{"key":"Description","value":"-"}]},{"database":"GO","id":"GO:0000439","properties":[{"key":"GoTerm","value":"C:transcription factor TFIIH core complex"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0005675","properties":[{"key":"GoTerm","value":"C:transcription factor TFIIH holo complex"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:0008270","properties":[{"key":"GoTerm","value":"F:zinc ion binding"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0006351","properties":[{"key":"GoTerm","value":"P:DNA-templated transcription"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0006289","properties":[{"key":"GoTerm","value":"P:nucleotide-excision repair"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0006357","properties":[{"key":"GoTerm","value":"P:regulation of transcription by RNA polymerase II"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"CDD","id":"cd20335","properties":[{"key":"EntryName","value":"BRcat_RBR"},{"key":"MatchStatus","value":"1"}]},{"database":"CDD","id":"cd01453","properties":[{"key":"EntryName","value":"vWA_transcription_factor_IIH_type"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.30.40.10:FF:000449","properties":[{"key":"EntryName","value":"General transcription factor IIH subunit"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.40.50.410:FF:000015","properties":[{"key":"EntryName","value":"General transcription factor IIH subunit 2"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.40.50.410","properties":[{"key":"EntryName","value":"von Willebrand factor, type A domain"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.30.40.10","properties":[{"key":"EntryName","value":"Zinc/RING finger domain, C3HC4 (zinc finger)"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR046349","properties":[{"key":"EntryName","value":"C1-like_sf"}]},{"database":"InterPro","id":"IPR007198","properties":[{"key":"EntryName","value":"Ssl1-like"}]},{"database":"InterPro","id":"IPR004595","properties":[{"key":"EntryName","value":"TFIIH_C1-like_dom"}]},{"database":"InterPro","id":"IPR012170","properties":[{"key":"EntryName","value":"TFIIH_SSL1/p44"}]},{"database":"InterPro","id":"IPR002035","properties":[{"key":"EntryName","value":"VWF_A"}]},{"database":"InterPro","id":"IPR036465","properties":[{"key":"EntryName","value":"vWFA_dom_sf"}]},{"database":"InterPro","id":"IPR013087","properties":[{"key":"EntryName","value":"Zf-C2H2_type"}]},{"database":"InterPro","id":"IPR060271","properties":[{"key":"EntryName","value":"Zn_ribbon_GTF2H2"}]},{"database":"InterPro","id":"IPR013083","properties":[{"key":"EntryName","value":"Znf_RING/FYVE/PHD"}]},{"database":"NCBIfam","id":"TIGR00622","properties":[{"key":"EntryName","value":"ssl1"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR12695","properties":[{"key":"EntryName","value":"GENERAL TRANSCRIPTION FACTOR IIH SUBUNIT 2"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR12695:SF2","properties":[{"key":"EntryName","value":"GENERAL TRANSCRIPTION FACTOR IIH SUBUNIT 2-RELATED"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF07975","properties":[{"key":"EntryName","value":"C1_4"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF04056","properties":[{"key":"EntryName","value":"Ssl1"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF27618","properties":[{"key":"EntryName","value":"Zn_ribbon_GTF2H2"},{"key":"MatchStatus","value":"1"}]},{"database":"PIRSF","id":"PIRSF015919","properties":[{"key":"EntryName","value":"TFIIH_SSL1"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM01047","properties":[{"key":"EntryName","value":"C1_4"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00327","properties":[{"key":"EntryName","value":"VWA"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF57889","properties":[{"key":"EntryName","value":"Cysteine-rich domain"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF53300","properties":[{"key":"EntryName","value":"vWA-like"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00028","properties":[{"key":"EntryName","value":"ZINC_FINGER_C2H2_1"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"DEEDDDEGQNAWERDYADERSWESLQEDESGLLFPIDTKSLVHAQYRRRLLASARIQKGLIRYLYVVIDLSRAAAETDYRPTRMAVVAKCAETFMREFLDQNPLSHIGLVTIKDGVAQCVTELGGTPDSQIKALMGKLECSGDASLQNALELVHGTLSQIPSYGHREVLIFYSALNTCDPGDIMETIKKCKSAKIRCSVVGLSAEVFICKHLCEETGGSYTVALDESHFKELLLEHAPPPPAIAEYALSSLIKMGFPQRGADGVISICSCHKEVKVGGGYTCPRCKARLCELPTECRICGLTLVSSPHLARSYHHLFPVTPFNEVQSTSRFYQKVPQTCFGCQQNLMIQGSNSSQHVSCPKCNQHFCLDCDIYIHESLHNCPGCESQR","length":388,"molWeight":43103,"crc64":"AE4D6D108D1F5CFB","md5":"AB62417F535125385F6ECACCFC82A763"},"extraAttributes":{"countByCommentType":{"SUBCELLULAR LOCATION":1,"SIMILARITY":1},"countByFeatureType":{"Domain":1,"Zinc finger":1,"Non-terminal residue":2},"uniParcId":"UPI00052AADFA"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0A097PRS9","uniProtkbId":"A0A097PRS9_9LILI","entryAudit":{"firstPublicDate":"2015-01-07","lastAnnotationUpdateDate":"2026-11-04","lastSequenceUpdateDate":"2015-01-07","entryVersion":38,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Lilium brownii","commonName":"Hong Kong lily","taxonId":82312,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AIU50730.1"}],"lineage":["Eukaryota","Viridiplantae","Streptophyta","Embryophyta","Tracheophyta","Spermatophyta","Magnoliopsida","Liliopsida","Liliales","Liliaceae","Lilium"]},"proteinExistence":"2: Evidence at transcript level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00018778"}],"value":"Protein arginine N-methyltransferase 2"}},"alternativeNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00031001"}],"value":"Protein-arginine N5-methyltransferase"}},{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00031724"}],"value":"Type IV protein arginine N-methyltransferase"}}],"flag":"Fragment"},"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00002207"}],"value":"S-adenosyl-L-methionine-dependent protein-arginine N-methyltransferase that methylates the delta-nitrogen atom of arginine residues to form N5-methylarginine (type IV) in target proteins. Monomethylates ribosomal protein L12"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00011245"}],"value":"Monomer"}],"commentType":"SUBUNIT"},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004496"}],"value":"Cytoplasm","id":"SL-0086"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004123"}],"value":"Nucleus","id":"SL-0191"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00892"}],"value":"Belongs to the class I-like SAM-binding methyltransferase superfamily. RMT2 methyltransferase family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Repeat","location":{"start":{"value":30,"modifier":"EXACT"},"end":{"value":62,"modifier":"EXACT"}},"description":"ANK","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00023"}]},{"type":"Domain","location":{"start":{"value":98,"modifier":"EXACT"},"end":{"value":307,"modifier":"EXACT"}},"description":"RMT2","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS51559"}]},{"type":"Binding site","location":{"start":{"value":107,"modifier":"EXACT"},"end":{"value":107,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:59789"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00892"}],"ligand":{"name":"S-adenosyl-L-methionine","id":"ChEBI:CHEBI:59789"}},{"type":"Binding site","location":{"start":{"value":136,"modifier":"EXACT"},"end":{"value":136,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:59789"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00892"}],"ligand":{"name":"S-adenosyl-L-methionine","id":"ChEBI:CHEBI:59789"}},{"type":"Binding site","location":{"start":{"value":154,"modifier":"EXACT"},"end":{"value":159,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:59789"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00892"}],"ligand":{"name":"S-adenosyl-L-methionine","id":"ChEBI:CHEBI:59789"}},{"type":"Binding site","location":{"start":{"value":175,"modifier":"EXACT"},"end":{"value":177,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:59789"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00892"}],"ligand":{"name":"S-adenosyl-L-methionine","id":"ChEBI:CHEBI:59789"}},{"type":"Binding site","location":{"start":{"value":202,"modifier":"EXACT"},"end":{"value":203,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:59789"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00892"}],"ligand":{"name":"S-adenosyl-L-methionine","id":"ChEBI:CHEBI:59789"}},{"type":"Binding site","location":{"start":{"value":218,"modifier":"EXACT"},"end":{"value":218,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:59789"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00892"}],"ligand":{"name":"S-adenosyl-L-methionine","id":"ChEBI:CHEBI:59789"}},{"type":"Non-terminal residue","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":1,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AIU50730.1"}]},{"type":"Non-terminal residue","location":{"start":{"value":307,"modifier":"EXACT"},"end":{"value":307,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AIU50730.1"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00023"}],"id":"KW-0040","category":"Domain","name":"ANK repeat"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022490"}],"id":"KW-0963","category":"Cellular component","name":"Cytoplasm"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022603"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00892"}],"id":"KW-0489","category":"Molecular function","name":"Methyltransferase"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023242"}],"id":"KW-0539","category":"Cellular component","name":"Nucleus"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022691"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00892"}],"id":"KW-0949","category":"Ligand","name":"S-adenosyl-L-methionine"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022679"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00892"}],"id":"KW-0808","category":"Molecular function","name":"Transferase"}],"references":[{"referenceNumber":1,"citation":{"id":"25249442","citationType":"journal article","authors":["Zeng L.","Zhang Q.","Sun R.","Kong H.","Zhang N.","Ma H."],"citationCrossReferences":[{"database":"PubMed","id":"25249442"},{"database":"DOI","id":"10.1038/ncomms5956"}],"title":"Resolution of deep angiosperm phylogeny using conserved nuclear genes and estimates of early divergence times.","publicationDate":"2014","journal":"Nat. Commun.","firstPage":"4956","lastPage":"4956","volume":"5"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AIU50730.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"KM400097","properties":[{"key":"ProteinId","value":"AIU50730.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"AlphaFoldDB","id":"A0A097PRS9","properties":[{"key":"Description","value":"-"}]},{"database":"GO","id":"GO:0005737","properties":[{"key":"GoTerm","value":"C:cytoplasm"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0005634","properties":[{"key":"GoTerm","value":"C:nucleus"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0016274","properties":[{"key":"GoTerm","value":"F:protein-arginine N-methyltransferase activity"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0046500","properties":[{"key":"GoTerm","value":"P:S-adenosylmethionine metabolic process"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniRule"}]},{"database":"CDD","id":"cd02440","properties":[{"key":"EntryName","value":"AdoMet_MTases"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.40.50.150:FF:000135","properties":[{"key":"EntryName","value":"Arginine N-methyltransferase 2"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.25.40.20:FF:000307","properties":[{"key":"EntryName","value":"Protein arginine N-methyltransferase 2"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.25.40.20","properties":[{"key":"EntryName","value":"Ankyrin repeat-containing domain"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.40.50.150","properties":[{"key":"EntryName","value":"Vaccinia Virus protein VP39"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR002110","properties":[{"key":"EntryName","value":"Ankyrin_rpt"}]},{"database":"InterPro","id":"IPR036770","properties":[{"key":"EntryName","value":"Ankyrin_rpt-contain_sf"}]},{"database":"InterPro","id":"IPR017408","properties":[{"key":"EntryName","value":"Arginine_N-MeTrfase_2"}]},{"database":"InterPro","id":"IPR051038","properties":[{"key":"EntryName","value":"RMT2/GAMT_Mtase"}]},{"database":"InterPro","id":"IPR026480","properties":[{"key":"EntryName","value":"RMT2_dom"}]},{"database":"InterPro","id":"IPR029063","properties":[{"key":"EntryName","value":"SAM-dependent_MTases_sf"}]},{"database":"PANTHER","id":"PTHR32379","properties":[{"key":"EntryName","value":"GUANIDINOACETATE N-METHYLTRANSFERASE"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR32379:SF1","properties":[{"key":"EntryName","value":"GUANIDINOACETATE N-METHYLTRANSFERASE"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF12796","properties":[{"key":"EntryName","value":"Ank_2"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF27704","properties":[{"key":"EntryName","value":"GuanidinoAc_N-MeTrfase"},{"key":"MatchStatus","value":"1"}]},{"database":"PIRSF","id":"PIRSF038148","properties":[{"key":"EntryName","value":"Arginine_N-mtfrase-2"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00248","properties":[{"key":"EntryName","value":"ANK"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF48403","properties":[{"key":"EntryName","value":"Ankyrin repeat"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF53335","properties":[{"key":"EntryName","value":"S-adenosyl-L-methionine-dependent methyltransferases"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50297","properties":[{"key":"EntryName","value":"ANK_REP_REGION"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50088","properties":[{"key":"EntryName","value":"ANK_REPEAT"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS51559","properties":[{"key":"EntryName","value":"SAM_RMT2"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"LLCEAAVAGDCAKITALVSTGADASHFDAVGTTPLMHAARHGHADAVRCLLSAGAPWNALSPSGNSAGDLAMDHDAFDVLLNAGIQSELILGTIARYETKSAAAPNYLEARVAFSEEKLMDSESKAVMMAWEKPLMEAHARAISGGGRVLNVGFGMGLVDEAIQRYKPEEHTIVEAHPEVYERMIQLGWGEKENVKIVFGRWQDVIPQLGSYDGIFFDTYGEYYEDLMQFHEHLPRLLKPGGIYSYFNGLCGGNAFFHVVYCQLVSLELGNLGYSTQFIPLPVKNCLAEEVWEGVKQKYWQLDTYYL","length":307,"molWeight":33819,"crc64":"66997DFA34ACB314","md5":"9215A63B209F32CF8B127087CD56D251"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"SUBUNIT":1,"SUBCELLULAR LOCATION":1,"SIMILARITY":1},"countByFeatureType":{"Repeat":1,"Domain":1,"Binding site":6,"Non-terminal residue":2},"uniParcId":"UPI00052AF93A"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0A097PS57","uniProtkbId":"A0A097PS57_9LILI","entryAudit":{"firstPublicDate":"2015-01-07","lastAnnotationUpdateDate":"2026-11-04","lastSequenceUpdateDate":"2015-01-07","entryVersion":24,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Lilium brownii","commonName":"Hong Kong lily","taxonId":82312,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AIU50838.1"}],"lineage":["Eukaryota","Viridiplantae","Streptophyta","Embryophyta","Tracheophyta","Spermatophyta","Magnoliopsida","Liliopsida","Liliales","Liliaceae","Lilium"]},"proteinExistence":"2: Evidence at transcript level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00011926"}],"value":"mRNA (guanine-N(7))-methyltransferase"},"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00011926"}],"value":"2.1.1.56"}]},"flag":"Fragment"},"comments":[{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"a 5'-end (5'-triphosphoguanosine)-ribonucleoside in mRNA + S-adenosyl-L-methionine = a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in mRNA + S-adenosyl-L-homocysteine","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:67008"},{"database":"Rhea","id":"RHEA-COMP:17166"},{"database":"Rhea","id":"RHEA-COMP:17167"},{"database":"ChEBI","id":"CHEBI:57856"},{"database":"ChEBI","id":"CHEBI:59789"},{"database":"ChEBI","id":"CHEBI:156461"},{"database":"ChEBI","id":"CHEBI:167617"}],"ecNumber":"2.1.1.56","evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00044712"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00895"}]}},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00895"}],"value":"Belongs to the class I-like SAM-binding methyltransferase superfamily. mRNA cap 0 methyltransferase family"}],"commentType":"SIMILARITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00895"}],"value":"Lacks conserved residue(s) required for the propagation of feature annotation"}],"commentType":"CAUTION"}],"features":[{"type":"Domain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":85,"modifier":"EXACT"}},"description":"MRNA cap 0 methyltransferase","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS51562"}]},{"type":"Non-terminal residue","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":1,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AIU50838.1"}]},{"type":"Non-terminal residue","location":{"start":{"value":85,"modifier":"EXACT"},"end":{"value":85,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AIU50838.1"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022603"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00895"}],"id":"KW-0489","category":"Molecular function","name":"Methyltransferase"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023042"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00895"}],"id":"KW-0506","category":"Biological process","name":"mRNA capping"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00895"}],"id":"KW-0507","category":"Biological process","name":"mRNA processing"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022884"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00895"}],"id":"KW-0694","category":"Molecular function","name":"RNA-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022691"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00895"}],"id":"KW-0949","category":"Ligand","name":"S-adenosyl-L-methionine"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022679"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00895"}],"id":"KW-0808","category":"Molecular function","name":"Transferase"}],"references":[{"referenceNumber":1,"citation":{"id":"25249442","citationType":"journal article","authors":["Zeng L.","Zhang Q.","Sun R.","Kong H.","Zhang N.","Ma H."],"citationCrossReferences":[{"database":"PubMed","id":"25249442"},{"database":"DOI","id":"10.1038/ncomms5956"}],"title":"Resolution of deep angiosperm phylogeny using conserved nuclear genes and estimates of early divergence times.","publicationDate":"2014","journal":"Nat. Commun.","firstPage":"4956","lastPage":"4956","volume":"5"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AIU50838.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"KM400205","properties":[{"key":"ProteinId","value":"AIU50838.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"AlphaFoldDB","id":"A0A097PS57","properties":[{"key":"Description","value":"-"}]},{"database":"GO","id":"GO:0005634","properties":[{"key":"GoTerm","value":"C:nucleus"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:0004482","properties":[{"key":"GoTerm","value":"F:mRNA 5'-cap (guanine-N7-)-methyltransferase activity"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniRule"}]},{"database":"GO","id":"GO:0003723","properties":[{"key":"GoTerm","value":"F:RNA binding"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniRule"}]},{"database":"GO","id":"GO:0046500","properties":[{"key":"GoTerm","value":"P:S-adenosylmethionine metabolic process"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniRule"}]},{"database":"Gene3D","id":"3.40.50.150","properties":[{"key":"EntryName","value":"Vaccinia Virus protein VP39"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR004971","properties":[{"key":"EntryName","value":"mRNA_G-N7_MeTrfase_dom"}]},{"database":"InterPro","id":"IPR039753","properties":[{"key":"EntryName","value":"RG7MT1"}]},{"database":"InterPro","id":"IPR029063","properties":[{"key":"EntryName","value":"SAM-dependent_MTases_sf"}]},{"database":"PANTHER","id":"PTHR12189:SF3","properties":[{"key":"EntryName","value":"MRNA (GUANINE-N(7))-METHYLTRANSFERASE"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR12189","properties":[{"key":"EntryName","value":"MRNA GUANINE-7- METHYLTRANSFERASE"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF03291","properties":[{"key":"EntryName","value":"mRNA_G-N7_MeTrfase"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS51562","properties":[{"key":"EntryName","value":"RNA_CAP0_MT"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"LMCNVSAMLRPGGYFFGITADSSAIWTKYQKNVEASHNKNTVPTCIKSENYVITFEVEEEKFPCFGKRYQIKFPNDHYLVHFPSL","length":85,"molWeight":9828,"crc64":"4ABB17EFF3C46E22","md5":"7DD2A6F2C50D95B3A3899EC66E0C629C"},"extraAttributes":{"countByCommentType":{"CATALYTIC ACTIVITY":1,"SIMILARITY":1,"CAUTION":1},"countByFeatureType":{"Domain":1,"Non-terminal residue":2},"uniParcId":"UPI00052A1409"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0A097PSV6","uniProtkbId":"A0A097PSV6_9LILI","entryAudit":{"firstPublicDate":"2015-01-07","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2015-01-07","entryVersion":15,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Lilium brownii","commonName":"Hong Kong lily","taxonId":82312,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AIU51105.1"}],"lineage":["Eukaryota","Viridiplantae","Streptophyta","Embryophyta","Tracheophyta","Spermatophyta","Magnoliopsida","Liliopsida","Liliales","Liliaceae","Lilium"]},"proteinExistence":"2: Evidence at transcript level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00020984"}],"value":"Conserved oligomeric Golgi complex subunit 7"}},"alternativeNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00031345"}],"value":"Component of oligomeric Golgi complex 7"}}],"flag":"Fragment"},"comments":[{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004395"}],"value":"Golgi apparatus membrane","id":"SL-0134"},"topology":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004395"}],"value":"Peripheral membrane protein","id":"SL-9903"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00005831"}],"value":"Belongs to the COG7 family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Non-terminal residue","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":1,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AIU51105.1"}]},{"type":"Non-terminal residue","location":{"start":{"value":450,"modifier":"EXACT"},"end":{"value":450,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AIU51105.1"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023034"}],"id":"KW-0333","category":"Cellular component","name":"Golgi apparatus"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023136"}],"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022927"}],"id":"KW-0653","category":"Biological process","name":"Protein transport"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022448"}],"id":"KW-0813","category":"Biological process","name":"Transport"}],"references":[{"referenceNumber":1,"citation":{"id":"25249442","citationType":"journal article","authors":["Zeng L.","Zhang Q.","Sun R.","Kong H.","Zhang N.","Ma H."],"citationCrossReferences":[{"database":"PubMed","id":"25249442"},{"database":"DOI","id":"10.1038/ncomms5956"}],"title":"Resolution of deep angiosperm phylogeny using conserved nuclear genes and estimates of early divergence times.","publicationDate":"2014","journal":"Nat. Commun.","firstPage":"4956","lastPage":"4956","volume":"5"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AIU51105.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"KM400476","properties":[{"key":"ProteinId","value":"AIU51105.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"AlphaFoldDB","id":"A0A097PSV6","properties":[{"key":"Description","value":"-"}]},{"database":"GO","id":"GO:0017119","properties":[{"key":"GoTerm","value":"C:COG complex"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0000139","properties":[{"key":"GoTerm","value":"C:Golgi membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0007030","properties":[{"key":"GoTerm","value":"P:Golgi organization"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:0006886","properties":[{"key":"GoTerm","value":"P:intracellular protein transport"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0006890","properties":[{"key":"GoTerm","value":"P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"InterPro","id":"IPR019335","properties":[{"key":"EntryName","value":"COG7"}]},{"database":"PANTHER","id":"PTHR21443","properties":[{"key":"EntryName","value":"CONSERVED OLIGOMERIC GOLGI COMPLEX COMPONENT 7"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR21443:SF0","properties":[{"key":"EntryName","value":"CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 7"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF10191","properties":[{"key":"EntryName","value":"COG7"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"LFSESDIQILLSTLKAIYSPFQPYKQRYGQMERAILSSEIAGIDIRGAVARGVGAQGIELSETVRRMEESIPQVIMLLESAVERCITFTGGSEVDELILALDEIMLQYISNLHETLKSLRVVCGVDNVTSSEGPKKDTGLDRKEGTRIMDMVSEEEEWSIVQGALQILTVADCLTSRSSVFEASLRSTLARIGTSLSLSVFGSSLDQSHGATNEGNGEVSLAGRAALDVAALHLADAPEKARKLFNLLEQSKDPRFHSLPLASQRVAAFADTVNELVYDVLISKVRQRLSEVSRLPIWSSVEEPSSLPLPSFSAYPQAYVTSVGEYLLTLPQQLEPLAEGISSSENNAEEAQFFATEWMFKVAEGATDLFMEQLRGIHYITERGAQQLSADIEYLTNVLSALSMPIPPFLTTFHTCLSTPRDQFRELLKADGGSQLDQPTAHLVCKIRRL","length":450,"molWeight":49478,"crc64":"D5643AC68EBD4F9C","md5":"132E5054F8DAE2013762B276A5D9AE76"},"extraAttributes":{"countByCommentType":{"SUBCELLULAR LOCATION":1,"SIMILARITY":1},"countByFeatureType":{"Non-terminal residue":2},"uniParcId":"UPI00052AF81F"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0A0A7E6W5","uniProtkbId":"A0A0A7E6W5_9LILI","entryAudit":{"firstPublicDate":"2015-03-04","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2015-03-04","entryVersion":30,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Lilium brownii","commonName":"Hong Kong lily","taxonId":82312,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AIY60783.1"}],"lineage":["Eukaryota","Viridiplantae","Streptophyta","Embryophyta","Tracheophyta","Spermatophyta","Magnoliopsida","Liliopsida","Liliales","Liliaceae","Lilium"]},"proteinExistence":"2: Evidence at transcript level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU362115"}],"value":"RHOMBOID-like protein"},"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU362115"}],"value":"3.4.21.105"}]},"flag":"Fragment"},"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU362115"}],"value":"Serine protease involved in intramembrane proteolysis"}],"commentType":"FUNCTION"},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"Cleaves type-1 transmembrane domains using a catalytic dyad composed of serine and histidine that are contributed by different transmembrane domains.","ecNumber":"3.4.21.105","evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00000156"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU362115"}]}},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004141"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU362115"}],"value":"Membrane","id":"SL-0162"},"topology":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004141"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU362115"}],"value":"Multi-pass membrane protein","id":"SL-9909"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00009045"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU362115"}],"value":"Belongs to the peptidase S54 family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Transmembrane","location":{"start":{"value":19,"modifier":"EXACT"},"end":{"value":41,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU362115"}]},{"type":"Transmembrane","location":{"start":{"value":101,"modifier":"EXACT"},"end":{"value":122,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU362115"}]},{"type":"Transmembrane","location":{"start":{"value":134,"modifier":"EXACT"},"end":{"value":152,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU362115"}]},{"type":"Transmembrane","location":{"start":{"value":158,"modifier":"EXACT"},"end":{"value":179,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU362115"}]},{"type":"Transmembrane","location":{"start":{"value":186,"modifier":"EXACT"},"end":{"value":205,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU362115"}]},{"type":"Transmembrane","location":{"start":{"value":211,"modifier":"EXACT"},"end":{"value":229,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU362115"}]},{"type":"Transmembrane","location":{"start":{"value":258,"modifier":"EXACT"},"end":{"value":280,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU362115"}]},{"type":"Domain","location":{"start":{"value":92,"modifier":"EXACT"},"end":{"value":228,"modifier":"EXACT"}},"description":"Peptidase S54 rhomboid","evidences":[{"evidenceCode":"ECO:0000259","source":"Pfam","id":"PF01694"}]},{"type":"Non-terminal residue","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":1,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AIY60783.1"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022801"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU362115"}],"id":"KW-0378","category":"Molecular function","name":"Hydrolase"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023136"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU362115"}],"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU362115"}],"id":"KW-0645","category":"Molecular function","name":"Protease"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU362115"}],"id":"KW-0720","category":"Molecular function","name":"Serine protease"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022692"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU362115"}],"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022989"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU362115"}],"id":"KW-1133","category":"Domain","name":"Transmembrane helix"}],"references":[{"referenceNumber":1,"citation":{"id":"CI-3D8CPL9VG8CF7","citationType":"submission","authors":["Zhang L."],"title":"Differential evolution of members of the rhomboid gene family with conservative and divergent patterns.","publicationDate":"OCT-2014","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AIY60783.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"KM823919","properties":[{"key":"ProteinId","value":"AIY60783.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"AlphaFoldDB","id":"A0A0A7E6W5","properties":[{"key":"Description","value":"-"}]},{"database":"GO","id":"GO:0005737","properties":[{"key":"GoTerm","value":"C:cytoplasm"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0012505","properties":[{"key":"GoTerm","value":"C:endomembrane system"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0016020","properties":[{"key":"GoTerm","value":"C:membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0004252","properties":[{"key":"GoTerm","value":"F:serine-type endopeptidase activity"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0006508","properties":[{"key":"GoTerm","value":"P:proteolysis"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"FunFam","id":"1.20.1540.10:FF:000019","properties":[{"key":"EntryName","value":"RHOMBOID-like protein"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.20.1540.10","properties":[{"key":"EntryName","value":"Rhomboid-like"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR002610","properties":[{"key":"EntryName","value":"Peptidase_S54_rhomboid-like"}]},{"database":"InterPro","id":"IPR022764","properties":[{"key":"EntryName","value":"Peptidase_S54_rhomboid_dom"}]},{"database":"InterPro","id":"IPR035952","properties":[{"key":"EntryName","value":"Rhomboid-like_sf"}]},{"database":"PANTHER","id":"PTHR22936:SF77","properties":[{"key":"EntryName","value":"RHOMBOID-LIKE PROTEIN 1"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR22936","properties":[{"key":"EntryName","value":"RHOMBOID-RELATED"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF01694","properties":[{"key":"EntryName","value":"Rhomboid"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF144091","properties":[{"key":"EntryName","value":"Rhomboid-like"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"PPPPPPPELRADPRPFRPWFPWLTPAIVAANIAVFVVTMYVNDCPDHSESCILKGIGRFSFQPMKQNPLLGPSANTLEKMGALEVNKVIRDHQGWRLFTCMWLHAGVFHLLANMLSLIFIGIRLEQEFGFVRIGLLYLISGFGGSLLSALFVQTSISVGASGALFGLLGAMLSELITNWTIYSNKLAALLTLVIITVINLAVGILPHVDNFAHIGGFVSGFCLGFVFLIRPQYRWVSQRNVPLGYRTGPVRKHKVYQYILWLIAAIVLITGFTVGLIMLFRGYSPNDHCSWCHYMSCVPTSLWHCNKTSNVYCLVSQTGNQYNLTCEGNGRFRTYMLPNASDTQIQGLCMQLCI","length":354,"molWeight":39460,"crc64":"6C0D4D590FA3E263","md5":"807C0CFDD02032A236D17BC2FA311164"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"CATALYTIC ACTIVITY":1,"SUBCELLULAR LOCATION":1,"SIMILARITY":1},"countByFeatureType":{"Transmembrane":7,"Domain":1,"Non-terminal residue":1},"uniParcId":"UPI000540700C"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0A0A7E707","uniProtkbId":"A0A0A7E707_9LILI","entryAudit":{"firstPublicDate":"2015-03-04","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2015-03-04","entryVersion":31,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Lilium brownii","commonName":"Hong Kong lily","taxonId":82312,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AIY60782.1"}],"lineage":["Eukaryota","Viridiplantae","Streptophyta","Embryophyta","Tracheophyta","Spermatophyta","Magnoliopsida","Liliopsida","Liliales","Liliaceae","Lilium"]},"proteinExistence":"2: Evidence at transcript level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU362115"}],"value":"RHOMBOID-like protein"},"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU362115"}],"value":"3.4.21.105"}]}},"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU362115"}],"value":"Serine protease involved in intramembrane proteolysis"}],"commentType":"FUNCTION"},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"Cleaves type-1 transmembrane domains using a catalytic dyad composed of serine and histidine that are contributed by different transmembrane domains.","ecNumber":"3.4.21.105","evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00000156"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU362115"}]}},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004141"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU362115"}],"value":"Membrane","id":"SL-0162"},"topology":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004141"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU362115"}],"value":"Multi-pass membrane protein","id":"SL-9909"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00009045"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU362115"}],"value":"Belongs to the peptidase S54 family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Transmembrane","location":{"start":{"value":39,"modifier":"EXACT"},"end":{"value":61,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU362115"}]},{"type":"Transmembrane","location":{"start":{"value":125,"modifier":"EXACT"},"end":{"value":146,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU362115"}]},{"type":"Transmembrane","location":{"start":{"value":158,"modifier":"EXACT"},"end":{"value":176,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU362115"}]},{"type":"Transmembrane","location":{"start":{"value":182,"modifier":"EXACT"},"end":{"value":203,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU362115"}]},{"type":"Transmembrane","location":{"start":{"value":210,"modifier":"EXACT"},"end":{"value":229,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU362115"}]},{"type":"Transmembrane","location":{"start":{"value":235,"modifier":"EXACT"},"end":{"value":253,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU362115"}]},{"type":"Transmembrane","location":{"start":{"value":283,"modifier":"EXACT"},"end":{"value":305,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU362115"}]},{"type":"Domain","location":{"start":{"value":116,"modifier":"EXACT"},"end":{"value":252,"modifier":"EXACT"}},"description":"Peptidase S54 rhomboid","evidences":[{"evidenceCode":"ECO:0000259","source":"Pfam","id":"PF01694"}]},{"type":"Region","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":28,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022801"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU362115"}],"id":"KW-0378","category":"Molecular function","name":"Hydrolase"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023136"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU362115"}],"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU362115"}],"id":"KW-0645","category":"Molecular function","name":"Protease"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU362115"}],"id":"KW-0720","category":"Molecular function","name":"Serine protease"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022692"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU362115"}],"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022989"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU362115"}],"id":"KW-1133","category":"Domain","name":"Transmembrane helix"}],"references":[{"referenceNumber":1,"citation":{"id":"CI-3D8CPL9VG8CF7","citationType":"submission","authors":["Zhang L."],"title":"Differential evolution of members of the rhomboid gene family with conservative and divergent patterns.","publicationDate":"OCT-2014","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AIY60782.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"KM823918","properties":[{"key":"ProteinId","value":"AIY60782.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"AlphaFoldDB","id":"A0A0A7E707","properties":[{"key":"Description","value":"-"}]},{"database":"GO","id":"GO:0005737","properties":[{"key":"GoTerm","value":"C:cytoplasm"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0012505","properties":[{"key":"GoTerm","value":"C:endomembrane system"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0016020","properties":[{"key":"GoTerm","value":"C:membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0004252","properties":[{"key":"GoTerm","value":"F:serine-type endopeptidase activity"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0006508","properties":[{"key":"GoTerm","value":"P:proteolysis"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"FunFam","id":"1.20.1540.10:FF:000019","properties":[{"key":"EntryName","value":"RHOMBOID-like protein"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.20.1540.10","properties":[{"key":"EntryName","value":"Rhomboid-like"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR002610","properties":[{"key":"EntryName","value":"Peptidase_S54_rhomboid-like"}]},{"database":"InterPro","id":"IPR022764","properties":[{"key":"EntryName","value":"Peptidase_S54_rhomboid_dom"}]},{"database":"InterPro","id":"IPR035952","properties":[{"key":"EntryName","value":"Rhomboid-like_sf"}]},{"database":"PANTHER","id":"PTHR22936:SF77","properties":[{"key":"EntryName","value":"RHOMBOID-LIKE PROTEIN 1"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR22936","properties":[{"key":"EntryName","value":"RHOMBOID-RELATED"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF01694","properties":[{"key":"EntryName","value":"Rhomboid"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF144091","properties":[{"key":"EntryName","value":"Rhomboid-like"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MGPPPPSGGEIHVDLEGGNSPLAGDPTLPRHDGSPIRPWFPWLVPGIFAANVAAFIVTMYINDCPAKSPFSMRCLGRRILGRFSFEPFKANRLLGPSATTLQKLGGLDANKVVQQHQLWRLISCIWLHAGVIHILANMLSLLFIGIRLEQEFGFVRIGLLYIISGFGGSMLSALFIQSSISVGASGALFGLLGSMLSELITNWTIYANKLAALLTLLFIIAINLAVGILPHVDNFTHIGGFISGFLLGFVFLIRPQFGWIQQKHVPPGYVTGPVKPKHKMYQYILWILAVIFLIVWFTLGLVMLLRGVNANDHCSWCHYLSCVPTAKWSCKSSSTFCYLSNNGTQVTVSCQGDGRNQSYSLPNATDDQLNQLCNQQCS","length":378,"molWeight":41480,"crc64":"66540F45B529B11C","md5":"E79036540FCB58776F448AF0AF6F5A80"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"CATALYTIC ACTIVITY":1,"SUBCELLULAR LOCATION":1,"SIMILARITY":1},"countByFeatureType":{"Transmembrane":7,"Domain":1,"Region":1},"uniParcId":"UPI000540FE06"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0A0A7E8A2","uniProtkbId":"A0A0A7E8A2_9LILI","entryAudit":{"firstPublicDate":"2015-03-04","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2015-03-04","entryVersion":33,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Lilium brownii","commonName":"Hong Kong lily","taxonId":82312,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AIY60781.1"}],"lineage":["Eukaryota","Viridiplantae","Streptophyta","Embryophyta","Tracheophyta","Spermatophyta","Magnoliopsida","Liliopsida","Liliales","Liliaceae","Lilium"]},"proteinExistence":"2: Evidence at transcript level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU362115"}],"value":"RHOMBOID-like protein"},"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU362115"}],"value":"3.4.21.105"}]},"flag":"Fragment"},"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU362115"}],"value":"Serine protease involved in intramembrane proteolysis"}],"commentType":"FUNCTION"},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"Cleaves type-1 transmembrane domains using a catalytic dyad composed of serine and histidine that are contributed by different transmembrane domains.","ecNumber":"3.4.21.105","evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00000156"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU362115"}]}},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004141"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU362115"}],"value":"Membrane","id":"SL-0162"},"topology":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004141"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU362115"}],"value":"Multi-pass membrane protein","id":"SL-9909"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00009045"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU362115"}],"value":"Belongs to the peptidase S54 family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Transmembrane","location":{"start":{"value":77,"modifier":"EXACT"},"end":{"value":96,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU362115"}]},{"type":"Transmembrane","location":{"start":{"value":159,"modifier":"EXACT"},"end":{"value":180,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU362115"}]},{"type":"Transmembrane","location":{"start":{"value":192,"modifier":"EXACT"},"end":{"value":210,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU362115"}]},{"type":"Transmembrane","location":{"start":{"value":216,"modifier":"EXACT"},"end":{"value":237,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU362115"}]},{"type":"Transmembrane","location":{"start":{"value":244,"modifier":"EXACT"},"end":{"value":263,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU362115"}]},{"type":"Transmembrane","location":{"start":{"value":269,"modifier":"EXACT"},"end":{"value":287,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU362115"}]},{"type":"Transmembrane","location":{"start":{"value":314,"modifier":"EXACT"},"end":{"value":336,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU362115"}]},{"type":"Domain","location":{"start":{"value":150,"modifier":"EXACT"},"end":{"value":286,"modifier":"EXACT"}},"description":"Peptidase S54 rhomboid","evidences":[{"evidenceCode":"ECO:0000259","source":"Pfam","id":"PF01694"}]},{"type":"Region","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":52,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Non-terminal residue","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":1,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AIY60781.1"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022801"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU362115"}],"id":"KW-0378","category":"Molecular function","name":"Hydrolase"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023136"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU362115"}],"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022670"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU362115"}],"id":"KW-0645","category":"Molecular function","name":"Protease"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022825"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU362115"}],"id":"KW-0720","category":"Molecular function","name":"Serine protease"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022692"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU362115"}],"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022989"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU362115"}],"id":"KW-1133","category":"Domain","name":"Transmembrane helix"}],"references":[{"referenceNumber":1,"citation":{"id":"CI-3D8CPL9VG8CF7","citationType":"submission","authors":["Zhang L."],"title":"Differential evolution of members of the rhomboid gene family with conservative and divergent patterns.","publicationDate":"OCT-2014","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AIY60781.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"KM823917","properties":[{"key":"ProteinId","value":"AIY60781.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"AlphaFoldDB","id":"A0A0A7E8A2","properties":[{"key":"Description","value":"-"}]},{"database":"GO","id":"GO:0005737","properties":[{"key":"GoTerm","value":"C:cytoplasm"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0012505","properties":[{"key":"GoTerm","value":"C:endomembrane system"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0016020","properties":[{"key":"GoTerm","value":"C:membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0004252","properties":[{"key":"GoTerm","value":"F:serine-type endopeptidase activity"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0006508","properties":[{"key":"GoTerm","value":"P:proteolysis"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"FunFam","id":"1.20.1540.10:FF:000019","properties":[{"key":"EntryName","value":"RHOMBOID-like protein"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.20.1540.10","properties":[{"key":"EntryName","value":"Rhomboid-like"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR002610","properties":[{"key":"EntryName","value":"Peptidase_S54_rhomboid-like"}]},{"database":"InterPro","id":"IPR022764","properties":[{"key":"EntryName","value":"Peptidase_S54_rhomboid_dom"}]},{"database":"InterPro","id":"IPR035952","properties":[{"key":"EntryName","value":"Rhomboid-like_sf"}]},{"database":"PANTHER","id":"PTHR22936:SF69","properties":[{"key":"EntryName","value":"RHOMBOID-LIKE PROTEIN"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR22936","properties":[{"key":"EntryName","value":"RHOMBOID-RELATED"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF01694","properties":[{"key":"EntryName","value":"Rhomboid"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF144091","properties":[{"key":"EntryName","value":"Rhomboid-like"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"KHHSTHLHLPSQANPRPLSNPSPPILPLHNFTPMSNPDLERGAKPARRPGPYGPAASNGGAFYYDGGAVAERGWTSWLVPLFVLANVAMFIVVMFVNNCPDHTSRFGSCTARFLHRFSFQPLRENPLLGPSSNTLEKLGALEWNKVVHEHQGWRLVSCIWLHAGVVHLLLNMLSLVFIGIRLEQQFGFMRIGVIYLVSGLGGSILSSLFIRNSISVGASGALFGLLGAMLSELIINWTIYSNKAAALFTLMVIIVINLAVGILPHVDNYAHIGGFLTGFLLGFIFLIRPQFAWLERHNLPPASQVKSKHKPYQYILLVIALLLLIAGLATGLVMLLRGENGNDHCHWCHYLSCVPTSRWSCGN","length":363,"molWeight":40019,"crc64":"45D329CE04CE71F1","md5":"4B7E09D6C0C953A1BC11501BA20816CE"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"CATALYTIC ACTIVITY":1,"SUBCELLULAR LOCATION":1,"SIMILARITY":1},"countByFeatureType":{"Transmembrane":7,"Domain":1,"Region":1,"Non-terminal residue":1},"uniParcId":"UPI0005412578"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0A7U3NRI2","uniProtkbId":"A0A7U3NRI2_9LILI","entryAudit":{"firstPublicDate":"2021-06-02","lastAnnotationUpdateDate":"2026-11-04","lastSequenceUpdateDate":"2021-06-02","entryVersion":17,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Lilium brownii","commonName":"Hong Kong lily","taxonId":82312,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"QOW94465.1"}],"lineage":["Eukaryota","Viridiplantae","Streptophyta","Embryophyta","Tracheophyta","Spermatophyta","Magnoliopsida","Liliopsida","Liliales","Liliaceae","Lilium"]},"proteinExistence":"2: Evidence at transcript level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00012588"}],"value":"starch synthase"},"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00012588"}],"value":"2.4.1.21"}]}},"comments":[{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"[(1->4)-alpha-D-glucosyl](n) + ADP-alpha-D-glucose = [(1->4)-alpha-D-glucosyl](n+1) + ADP + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:18189"},{"database":"Rhea","id":"RHEA-COMP:9584"},{"database":"Rhea","id":"RHEA-COMP:9587"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:15444"},{"database":"ChEBI","id":"CHEBI:57498"},{"database":"ChEBI","id":"CHEBI:456216"}],"ecNumber":"2.4.1.21","evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00001478"}]}},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004727"}],"value":"Glycan biosynthesis; starch biosynthesis"}],"commentType":"PATHWAY"},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004602"}],"value":"Plastid, amyloplast","id":"SL-0012"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004229"}],"value":"Plastid, chloroplast","id":"SL-0049"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00010281"}],"value":"Belongs to the glycosyltransferase 1 family. Bacterial/plant glycogen synthase subfamily"}],"commentType":"SIMILARITY"}],"features":[{"type":"Domain","location":{"start":{"value":309,"modifier":"EXACT"},"end":{"value":394,"modifier":"EXACT"}},"description":"Carbohydrate binding module family 25","evidences":[{"evidenceCode":"ECO:0000259","source":"SMART","id":"SM01066"}]},{"type":"Domain","location":{"start":{"value":483,"modifier":"EXACT"},"end":{"value":574,"modifier":"EXACT"}},"description":"Carbohydrate binding module family 25","evidences":[{"evidenceCode":"ECO:0000259","source":"SMART","id":"SM01066"}]},{"type":"Domain","location":{"start":{"value":645,"modifier":"EXACT"},"end":{"value":734,"modifier":"EXACT"}},"description":"Carbohydrate binding module family 25","evidences":[{"evidenceCode":"ECO:0000259","source":"SMART","id":"SM01066"}]},{"type":"Region","location":{"start":{"value":41,"modifier":"EXACT"},"end":{"value":110,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":252,"modifier":"EXACT"},"end":{"value":275,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":417,"modifier":"EXACT"},"end":{"value":452,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":80,"modifier":"EXACT"},"end":{"value":95,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":252,"modifier":"EXACT"},"end":{"value":275,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":417,"modifier":"EXACT"},"end":{"value":452,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023234"}],"id":"KW-0035","category":"Cellular component","name":"Amyloplast"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022528"}],"id":"KW-0150","category":"Cellular component","name":"Chloroplast"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022676"}],"id":"KW-0328","category":"Molecular function","name":"Glycosyltransferase"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022640"}],"id":"KW-0934","category":"Cellular component","name":"Plastid"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022922"}],"id":"KW-0750","category":"Biological process","name":"Starch biosynthesis"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022679"}],"id":"KW-0808","category":"Molecular function","name":"Transferase"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022946"}],"id":"KW-0809","category":"Domain","name":"Transit peptide"}],"references":[{"referenceNumber":1,"citation":{"id":"CI-58OFIJ08MNBUD","citationType":"submission","authors":["Wu Y.","Sun M.","Min R.","Gao C.","Li S.","Ren Z.","Xia Y."],"publicationDate":"JUL-2020","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"QOW94465.1"}],"value":"Bulb","type":"TISSUE"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"QOW94465.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"MT740694","properties":[{"key":"ProteinId","value":"QOW94465.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"AlphaFoldDB","id":"A0A7U3NRI2","properties":[{"key":"Description","value":"-"}]},{"database":"UniPathway","id":"UPA00152","properties":[{"key":"RectionId","value":"-"}]},{"database":"GO","id":"GO:0009501","properties":[{"key":"GoTerm","value":"C:amyloplast"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0009507","properties":[{"key":"GoTerm","value":"C:chloroplast"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0009011","properties":[{"key":"GoTerm","value":"F:alpha-1,4-glucan glucosyltransferase (ADP-glucose donor) activity"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-EC"}]},{"database":"GO","id":"GO:0004373","properties":[{"key":"GoTerm","value":"F:alpha-1,4-glucan glucosyltransferase (UDP-glucose donor) activity"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:2001070","properties":[{"key":"GoTerm","value":"F:starch binding"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0010021","properties":[{"key":"GoTerm","value":"P:amylopectin biosynthetic process"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0019252","properties":[{"key":"GoTerm","value":"P:starch biosynthetic process"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniPathway"}]},{"database":"CDD","id":"cd03791","properties":[{"key":"EntryName","value":"GT5_Glycogen_synthase_DULL1-like"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.40.50.2000:FF:000165","properties":[{"key":"EntryName","value":"Starch synthase, chloroplastic/amyloplastic"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.40.50.2000","properties":[{"key":"EntryName","value":"Glycogen Phosphorylase B"},{"key":"MatchStatus","value":"2"}]},{"database":"Gene3D","id":"2.60.40.10","properties":[{"key":"EntryName","value":"Immunoglobulins"},{"key":"MatchStatus","value":"2"}]},{"database":"HAMAP","id":"MF_00484","properties":[{"key":"EntryName","value":"Glycogen_synth"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR005085","properties":[{"key":"EntryName","value":"CBM25"}]},{"database":"InterPro","id":"IPR011835","properties":[{"key":"EntryName","value":"GS/SS"}]},{"database":"InterPro","id":"IPR013783","properties":[{"key":"EntryName","value":"Ig-like_fold"}]},{"database":"InterPro","id":"IPR013534","properties":[{"key":"EntryName","value":"Starch_synth_cat_dom"}]},{"database":"NCBIfam","id":"TIGR02095","properties":[{"key":"EntryName","value":"glgA"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR46083","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR46083:SF5","properties":[{"key":"EntryName","value":"STARCH SYNTHASE 3, CHLOROPLASTIC_AMYLOPLASTIC"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF16760","properties":[{"key":"EntryName","value":"CBM53"},{"key":"MatchStatus","value":"3"}]},{"database":"Pfam","id":"PF08323","properties":[{"key":"EntryName","value":"Glyco_transf_5"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM01066","properties":[{"key":"EntryName","value":"CBM_25"},{"key":"MatchStatus","value":"3"}]},{"database":"SUPFAM","id":"SSF53756","properties":[{"key":"EntryName","value":"UDP-Glycosyltransferase/glycogen phosphorylase"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MEMTLQLHAALGRRTGPSLGIFSQPPLQYKQITRIRIMPQMHAASSGSDYPRRRTRKSSIPMTKVAGPKGFAPRPQVRSDTQKKDLADSEGKEVSETSAPSDYTLPSPKISVTKGIGEEQITGLGSQSGVSLEMSDEIKDQRHGTEDTDEKALLGMLSTALDDNETDRQGAKTDGDGISLIKQYQEVVYNSGEIEDEREVVYNSGEIEDEKEVVYNSGEIEDGKVADIDEGPKDVGNLTEVDDRDKYLTDEELGSDKYLVDEEPDMESKSKQKADADALEQKQRLELVVEENFSRGTKVIIFPEEVKSEQSIEVLLNRSLTVLMSENDVFVKGSFNGWRWKSFTERMHKTDLKGDWWSCRLYVPKEAYRMDFVFFNGGTIYENNNYNDFSLSVHGGLDESSFEDFLLEEKQKELQRLAAEQAERERQAEEQRRREAEKAASEADRSQARAEVDKKRGAFQQVLTLAQSTGTVWYIEPSEFKGGDRVRLYYDRSSRPLEHAAKVWIHGGHNNWTNGLTIVESLIPSKKKDGDWWYADVSIPERALVLNWVFTDGPPQEAKVYDNNYSLDFHAIVPRSVSEEQFWVEEEHRIYTTLQEERKLKEKALREKVEKIASLKAEMKERTMKTFLTSQKHIVYTEPLVVRAGRLVTIFYNPSHTVLNGKPEIWLRYSFNRWTHRSGPLLPQKMVRSENGTHLEATVKVPLNAYIMDFVFSDTEYGGIYDNKNGRDYHIPVSGGICKEPPMHIVHISVEMAPIAKVGGLGDVVTSLSRAVQDLGHSVDIILPKYDCMNLSNVKDFHFHQSFFWKETEIKVWFGKVEGLSTFFLEPQNGMFSIGCIYGRNDADRFGFFCHAALQFLLQSGSHPDILHCHDWSSAPVAWLFKEHYIQYGLKSARLVFTIHNLEFGIQNISKAMAYADKATTVSPTYSKEVSGSPAVSPHLYKFHGIINGIDPNIWDPYNDNFIPVAYTSENVVEGKKAAKEALQQRLGLRSSDQPLLGIITRLTVQKGIDLIKHAIWKTLERNGQVVLLGSAPDPRIQNDFVNLANQLHSSHGDRVRLCLTYDEPLSHLIYAGSDFILVPSIFEPCGLTQLIAMRYGSIPVVRKTGGLYDTVFDVDNDKERAQAQGLEPNGFSFDGADSGGVEYALNRAISTWYDNRQLFKSLCKCVMEQDWSWNRPALDYMELYHAARKI","length":1191,"molWeight":135090,"crc64":"E3F9899122633EE4","md5":"DC0A82EE808FA7691D1638D1B611742D"},"extraAttributes":{"countByCommentType":{"CATALYTIC ACTIVITY":1,"PATHWAY":1,"SUBCELLULAR LOCATION":1,"SIMILARITY":1},"countByFeatureType":{"Domain":3,"Region":3,"Compositional bias":3},"uniParcId":"UPI0018C146DE"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0A7U3S1G0","uniProtkbId":"A0A7U3S1G0_9LILI","entryAudit":{"firstPublicDate":"2021-06-02","lastAnnotationUpdateDate":"2026-01-28","lastSequenceUpdateDate":"2021-06-02","entryVersion":12,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Lilium brownii","commonName":"Hong Kong lily","taxonId":82312,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"QOW94464.1"}],"lineage":["Eukaryota","Viridiplantae","Streptophyta","Embryophyta","Tracheophyta","Spermatophyta","Magnoliopsida","Liliopsida","Liliales","Liliaceae","Lilium"]},"proteinExistence":"2: Evidence at transcript level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU361232"}],"value":"Starch synthase, chloroplastic/amyloplastic"},"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU361232"}],"value":"2.4.1.-"}]}},"comments":[{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"an NDP-alpha-D-glucose + [(1->4)-alpha-D-glucosyl](n) = [(1->4)-alpha-D-glucosyl](n+1) + a ribonucleoside 5'-diphosphate + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:15873"},{"database":"Rhea","id":"RHEA-COMP:9584"},{"database":"Rhea","id":"RHEA-COMP:9587"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:15444"},{"database":"ChEBI","id":"CHEBI:57930"},{"database":"ChEBI","id":"CHEBI:76533"}],"ecNumber":"2.4.1.242","evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00047496"}]}},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004727"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU361232"}],"value":"Glycan biosynthesis; starch biosynthesis"}],"commentType":"PATHWAY"},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU361232"}],"value":"Plastid, chloroplast","id":"SL-0049"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU361232"}],"value":"Plastid, amyloplast","id":"SL-0012"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00010281"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU361232"}],"value":"Belongs to the glycosyltransferase 1 family. Bacterial/plant glycogen synthase subfamily"}],"commentType":"SIMILARITY"}],"features":[{"type":"Domain","location":{"start":{"value":82,"modifier":"EXACT"},"end":{"value":339,"modifier":"EXACT"}},"description":"Starch synthase catalytic","evidences":[{"evidenceCode":"ECO:0000259","source":"Pfam","id":"PF08323"}]},{"type":"Domain","location":{"start":{"value":394,"modifier":"EXACT"},"end":{"value":518,"modifier":"EXACT"}},"description":"Glycosyl transferase family 1","evidences":[{"evidenceCode":"ECO:0000259","source":"Pfam","id":"PF00534"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023234"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU361232"}],"id":"KW-0035","category":"Cellular component","name":"Amyloplast"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022528"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU361232"}],"id":"KW-0150","category":"Cellular component","name":"Chloroplast"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022676"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU361232"}],"id":"KW-0328","category":"Molecular function","name":"Glycosyltransferase"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022640"}],"id":"KW-0934","category":"Cellular component","name":"Plastid"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022922"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU361232"}],"id":"KW-0750","category":"Biological process","name":"Starch biosynthesis"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022679"}],"id":"KW-0808","category":"Molecular function","name":"Transferase"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022946"}],"id":"KW-0809","category":"Domain","name":"Transit peptide"}],"references":[{"referenceNumber":1,"citation":{"id":"CI-58OFIJ08MNBUD","citationType":"submission","authors":["Wu Y.","Sun M.","Min R.","Gao C.","Li S.","Ren Z.","Xia Y."],"publicationDate":"JUL-2020","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"QOW94464.1"}],"value":"Bulb","type":"TISSUE"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"QOW94464.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"MT740693","properties":[{"key":"ProteinId","value":"QOW94464.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"AlphaFoldDB","id":"A0A7U3S1G0","properties":[{"key":"Description","value":"-"}]},{"database":"UniPathway","id":"UPA00152","properties":[{"key":"RectionId","value":"-"}]},{"database":"GO","id":"GO:0009501","properties":[{"key":"GoTerm","value":"C:amyloplast"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0009507","properties":[{"key":"GoTerm","value":"C:chloroplast"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0004373","properties":[{"key":"GoTerm","value":"F:alpha-1,4-glucan glucosyltransferase (UDP-glucose donor) activity"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0019863","properties":[{"key":"GoTerm","value":"F:IgE binding"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0019252","properties":[{"key":"GoTerm","value":"P:starch biosynthetic process"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniRule"}]},{"database":"CDD","id":"cd03791","properties":[{"key":"EntryName","value":"GT5_Glycogen_synthase_DULL1-like"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.40.50.2000:FF:000073","properties":[{"key":"EntryName","value":"Starch synthase, chloroplastic/amyloplastic"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.40.50.2000:FF:000090","properties":[{"key":"EntryName","value":"Starch synthase, chloroplastic/amyloplastic"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.40.50.2000","properties":[{"key":"EntryName","value":"Glycogen Phosphorylase B"},{"key":"MatchStatus","value":"2"}]},{"database":"HAMAP","id":"MF_00484","properties":[{"key":"EntryName","value":"Glycogen_synth"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR001296","properties":[{"key":"EntryName","value":"Glyco_trans_1"}]},{"database":"InterPro","id":"IPR011835","properties":[{"key":"EntryName","value":"GS/SS"}]},{"database":"InterPro","id":"IPR013534","properties":[{"key":"EntryName","value":"Starch_synth_cat_dom"}]},{"database":"NCBIfam","id":"TIGR02095","properties":[{"key":"EntryName","value":"glgA"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR45825","properties":[{"key":"EntryName","value":"GRANULE-BOUND STARCH SYNTHASE 1, CHLOROPLASTIC/AMYLOPLASTIC"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR45825:SF17","properties":[{"key":"EntryName","value":"STARCH SYNTHASE, CHLOROPLASTIC_AMYLOPLASTIC"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF08323","properties":[{"key":"EntryName","value":"Glyco_transf_5"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00534","properties":[{"key":"EntryName","value":"Glycos_transf_1"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF53756","properties":[{"key":"EntryName","value":"UDP-Glycosyltransferase/glycogen phosphorylase"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MAASATPHFMIKSYQQGALEWRPRAFLIPNLTPLSAAYQGLRRLKPVDSLQMRATTRSTPRQCGRAVNCGGAISCSTGMNLVYVGTETGPHSKTGGLGDVLGGLPPAMAARGHRVMVVTPRYDQYKDAWDTGVVAEFKVGDKIETVRYFHLYKRGVDRVFIDHPWFLEKVWGKTGGKLYGPVTGTDYDDNQLRFSLLCLAALEAPRVLNLNNSEFFSGPYGEDVVFIANDWHTGPLSCYLKSMYQSVGIYKSAKVAFCIHNIAYQGRFPFADFSLLNLPDKFKSSFDFFDGYLKPVKGRKINWMRAGILEADAVVTVSPYYAKELVSGEDKGVELDKDITMIGIKGIVNGMDINFWNPLTDKYITANYDATTVMEAKRVNKQALQAEVGLPVDPDIPVIVFVGRLEEQKGSDILTAAIPDFIDENVQIIILGTGKKIFEKQVEEIEEKYPDKARGIAKFNIPLAHMMMAGGDLIIVPSRFEPCGLIQLEGMQYGMPVICSTTGGLVDTVKEGFTGFHMGAFTVNCEAIDPVDVVATVKTVKKALKVYGTPAFSEMVQNCMAQDLSWKGPAKKWEELLLGLGVHGSQPGIDGEEIAPMSKENVATP","length":605,"molWeight":66569,"crc64":"EC687C842745FFA5","md5":"48EB78F27DD491537E9895B0C60F7A5F"},"extraAttributes":{"countByCommentType":{"CATALYTIC ACTIVITY":1,"PATHWAY":1,"SUBCELLULAR LOCATION":1,"SIMILARITY":1},"countByFeatureType":{"Domain":2},"uniParcId":"UPI0018C1A556"}}]}