{"results":[{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"P0CE16","secondaryAccessions":["P08781","P10555","P22445"],"uniProtkbId":"GP1D_CHLTH","entryAudit":{"firstPublicDate":"2010-03-02","lastAnnotationUpdateDate":"2026-11-04","lastSequenceUpdateDate":"2010-03-02","entryVersion":68,"sequenceVersion":1},"annotationScore":4.0,"organism":{"scientificName":"Chlamydia trachomatis","taxonId":813,"lineage":["Bacteria","Pseudomonadati","Chlamydiota","Chlamydiia","Chlamydiales","Chlamydiaceae","Chlamydia/Chlamydophila group","Chlamydia"]},"proteinExistence":"3: Inferred from homology","proteinDescription":{"recommendedName":{"fullName":{"value":"Probable plasmid replicative DNA helicase"},"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P0ACB0"}],"value":"5.6.2.3"}]},"alternativeNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"DNA 5'-3' helicase pGP1-D"}},{"fullName":{"value":"DnaB-like protein"}},{"fullName":{"value":"Protein P-3"}},{"fullName":{"value":"Virulence plasmid protein pGP1-D"}}]},"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P0ACB0"}],"value":"A replicative DNA helicase, it participates in initiation and elongation during DNA replication. Travels ahead of the DNA replisome, separating dsDNA into templates for DNA synthesis. A processive ATP-dependent 5'-3' DNA helicase it has DNA-dependent ATPase activity"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305","source":"PubMed","id":"2194229"}],"value":"The plasmid this protein is encoded on is thought to be required for growth within mammalian cells"}],"commentType":"FUNCTION"},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"Couples ATP hydrolysis with the unwinding of duplex DNA at the replication fork by translocating in the 5'-3' direction.","ecNumber":"5.6.2.3","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P0ACB0"}]}},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"ATP + H2O = ADP + phosphate + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:13065"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:30616"},{"database":"ChEBI","id":"CHEBI:43474"},{"database":"ChEBI","id":"CHEBI:456216"}],"ecNumber":"5.6.2.3","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P0ACB0"}]}},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P0ACB0"}],"value":"Homohexamer"}],"commentType":"SUBUNIT"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Belongs to the helicase family. DnaB subfamily"}],"commentType":"SIMILARITY"},{"commentType":"SEQUENCE CAUTION","sequenceCautionType":"Frameshift","sequence":"AAB02586.1","evidences":[{"evidenceCode":"ECO:0000305"}]},{"commentType":"SEQUENCE CAUTION","sequenceCautionType":"Frameshift","sequence":"CAA68558.1","evidences":[{"evidenceCode":"ECO:0000305"}]}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":451,"modifier":"EXACT"}},"description":"Probable plasmid replicative DNA helicase","featureId":"PRO_0000102038"},{"type":"Domain","location":{"start":{"value":194,"modifier":"EXACT"},"end":{"value":451,"modifier":"EXACT"}},"description":"SF4 helicase","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00596"}]},{"type":"Binding site","location":{"start":{"value":225,"modifier":"EXACT"},"end":{"value":232,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:30616"}],"evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00596"}],"ligand":{"name":"ATP","id":"ChEBI:CHEBI:30616"}},{"type":"Natural variant","location":{"start":{"value":55,"modifier":"EXACT"},"end":{"value":55,"modifier":"EXACT"}},"description":"in plasmid pCHL1","featureId":"","alternativeSequence":{"originalSequence":"Y","alternativeSequences":["H"]}},{"type":"Natural variant","location":{"start":{"value":188,"modifier":"EXACT"},"end":{"value":188,"modifier":"EXACT"}},"description":"in plasmid pCHL1","featureId":"","alternativeSequence":{"originalSequence":"A","alternativeSequences":["V"]}},{"type":"Natural variant","location":{"start":{"value":189,"modifier":"EXACT"},"end":{"value":189,"modifier":"EXACT"}},"description":"in plasmid pCHL1 and plasmid pCTT1","featureId":"","alternativeSequence":{"originalSequence":"T","alternativeSequences":["A"]}},{"type":"Natural variant","location":{"start":{"value":200,"modifier":"EXACT"},"end":{"value":200,"modifier":"EXACT"}},"description":"in plasmid pCHL1 and plasmid pCTT1","featureId":"","alternativeSequence":{"originalSequence":"A","alternativeSequences":["G"]}},{"type":"Natural variant","location":{"start":{"value":267,"modifier":"EXACT"},"end":{"value":267,"modifier":"EXACT"}},"description":"in plasmid pCTT1","featureId":"","alternativeSequence":{"originalSequence":"I","alternativeSequences":["V"]}}],"geneLocations":[{"value":"pLGV440","geneEncodingType":"Plasmid"},{"value":"pCHL1","geneEncodingType":"Plasmid"},{"value":"pCTT1","geneEncodingType":"Plasmid"}],"keywords":[{"id":"KW-0067","category":"Ligand","name":"ATP-binding"},{"id":"KW-0235","category":"Biological process","name":"DNA replication"},{"id":"KW-0238","category":"Molecular function","name":"DNA-binding"},{"id":"KW-0347","category":"Molecular function","name":"Helicase"},{"id":"KW-0378","category":"Molecular function","name":"Hydrolase"},{"id":"KW-0413","category":"Molecular function","name":"Isomerase"},{"id":"KW-0547","category":"Ligand","name":"Nucleotide-binding"},{"id":"KW-0614","category":"Technical term","name":"Plasmid"},{"id":"KW-0639","category":"Cellular component","name":"Primosome"}],"references":[{"referenceNumber":1,"citation":{"id":"2836808","citationType":"journal article","authors":["Hatt C.","Ward M.E.","Clarke I.N."],"citationCrossReferences":[{"database":"PubMed","id":"2836808"},{"database":"DOI","id":"10.1093/nar/16.9.4053"}],"title":"Analysis of the entire nucleotide sequence of the cryptic plasmid of Chlamydia trachomatis serovar L1. Evidence for involvement in DNA replication.","publicationDate":"1988","journal":"Nucleic Acids Res.","firstPage":"4053","lastPage":"4067","volume":"16"},"referencePositions":["NUCLEOTIDE SEQUENCE [GENOMIC DNA]"],"referenceComments":[{"value":"L1/440/LN","type":"STRAIN"},{"value":"pLGV440","type":"PLASMID"}]},{"referenceNumber":2,"citation":{"id":"2194229","citationType":"journal article","authors":["Comanducci M.","Ricci S.","Cevenini R.","Ratti G."],"citationCrossReferences":[{"database":"PubMed","id":"2194229"},{"database":"DOI","id":"10.1016/0147-619x(90)90034-a"}],"title":"Diversity of the Chlamydia trachomatis common plasmid in biovars with different pathogenicity.","publicationDate":"1990","journal":"Plasmid","firstPage":"149","lastPage":"154","volume":"23"},"referencePositions":["NUCLEOTIDE SEQUENCE [GENOMIC DNA]"],"referenceComments":[{"value":"D/GO/86","type":"STRAIN"},{"value":"pCHL1","type":"PLASMID"}]},{"referenceNumber":3,"citation":{"id":"3444859","citationType":"journal article","authors":["Sriprakash K.S.","Macavoy E.S."],"citationCrossReferences":[{"database":"PubMed","id":"3444859"},{"database":"DOI","id":"10.1016/0147-619x(87)90063-1"}],"title":"Characterization and sequence of a plasmid from the trachoma biovar of Chlamydia trachomatis.","publicationDate":"1987","journal":"Plasmid","firstPage":"205","lastPage":"214","volume":"18"},"referencePositions":["NUCLEOTIDE SEQUENCE [GENOMIC DNA]"],"referenceComments":[{"value":"Serotype B","type":"STRAIN"},{"value":"pCTT1","type":"PLASMID"}]},{"referenceNumber":4,"citation":{"id":"2827127","citationType":"journal article","authors":["Sriprakash K.S.","Macavoy E.S."],"citationCrossReferences":[{"database":"PubMed","id":"2827127"},{"database":"DOI","id":"10.1093/nar/15.24.10596"}],"title":"A gene for dnaB like protein in chlamydial plasmid.","publicationDate":"1987","journal":"Nucleic Acids Res.","firstPage":"10596","lastPage":"10596","volume":"15"},"referencePositions":["NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-407"],"referenceComments":[{"value":"Serotype B","type":"STRAIN"},{"value":"pCTT1","type":"PLASMID"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"X06707","properties":[{"key":"ProteinId","value":"CAA29892.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"J03321","properties":[{"key":"ProteinId","value":"AAA91569.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"M19487","properties":[{"key":"ProteinId","value":"AAB02586.1"},{"key":"Status","value":"ALT_FRAME"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"Y00505","properties":[{"key":"ProteinId","value":"CAA68558.1"},{"key":"Status","value":"ALT_FRAME"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"PIR","id":"A37386","properties":[{"key":"EntryName","value":"A37386"}]},{"database":"PIR","id":"S01921","properties":[{"key":"EntryName","value":"S01921"}]},{"database":"PIR","id":"S06324","properties":[{"key":"EntryName","value":"S06324"}]},{"database":"RefSeq","id":"WP_010889884.1","properties":[{"key":"NucleotideSequenceId","value":"NC_001372.1"}]},{"database":"RefSeq","id":"WP_012209814.1","properties":[{"key":"NucleotideSequenceId","value":"NC_010286.1"}]},{"database":"AlphaFoldDB","id":"P0CE16","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"P0CE16","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"AIFGCPM","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"GO","id":"GO:0005829","properties":[{"key":"GoTerm","value":"C:cytosol"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:0043139","properties":[{"key":"GoTerm","value":"F:5'-3' DNA helicase activity"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0005524","properties":[{"key":"GoTerm","value":"F:ATP binding"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0016887","properties":[{"key":"GoTerm","value":"F:ATP hydrolysis activity"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0006260","properties":[{"key":"GoTerm","value":"P:DNA replication"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"CDD","id":"cd00984","properties":[{"key":"EntryName","value":"DnaB_C"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.40.50.300","properties":[{"key":"EntryName","value":"P-loop containing nucleotide triphosphate hydrolases"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR003593","properties":[{"key":"EntryName","value":"AAA+_ATPase"}]},{"database":"InterPro","id":"IPR036185","properties":[{"key":"EntryName","value":"DNA_heli_DnaB-like_N_sf"}]},{"database":"InterPro","id":"IPR007694","properties":[{"key":"EntryName","value":"DNA_helicase_DnaB-like_C"}]},{"database":"InterPro","id":"IPR007693","properties":[{"key":"EntryName","value":"DNA_helicase_DnaB-like_N"}]},{"database":"InterPro","id":"IPR027417","properties":[{"key":"EntryName","value":"P-loop_NTPase"}]},{"database":"PANTHER","id":"PTHR30153:SF2","properties":[{"key":"EntryName","value":"REPLICATIVE DNA HELICASE"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR30153","properties":[{"key":"EntryName","value":"REPLICATIVE DNA HELICASE DNAB"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00772","properties":[{"key":"EntryName","value":"DnaB"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF03796","properties":[{"key":"EntryName","value":"DnaB_C"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00382","properties":[{"key":"EntryName","value":"AAA"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF48024","properties":[{"key":"EntryName","value":"N-terminal domain of DnaB helicase"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF52540","properties":[{"key":"EntryName","value":"P-loop containing nucleoside triphosphate hydrolases"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS51199","properties":[{"key":"EntryName","value":"SF4_HELICASE"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MKTRSEIENRMQDIEYALLGKALIFEDSTEYILRQLANYEFKCSHHKNIFIVFKYLKDNGLPITVDSAWEELLRRRIKDMDKSYLGLMLHDALSNDKLRSVSHTVFLDDLSVCSAEENLSNFIFRSFNEYNENPLRRSPFLLLERIKGRLDSAIAKTFSIRSARGRSIYDIFSQSEIGVLARIKKRRATFSENQNSFFDAFPTGYKDIDDKGVILAKGNFVIIAARPSIGKTALAIDMAINLAVTQQRRVGFLSLEMSAGQIVERIIANLTGISGEKLQRGDLSKEELFRVEEAGETVRESHFYICSDSQYKLNLIANQIRLLRKEDRVDVIFIDYLQLINSSVGENRQNEIADISRTLRGLASELNIPIVCLSQLSRKVEDRANKVPMLSDLRDSGQIEQDADVILFINRKESSSNCEITVGKNRHGSVFSSVLHFDPKISKFSAIKKVW","length":451,"molWeight":51457,"crc64":"2CD73A152C72A1F1","md5":"7AF8A8A3B02BB5771EB22D469B7A2250"},"extraAttributes":{"countByCommentType":{"FUNCTION":2,"CATALYTIC ACTIVITY":2,"SUBUNIT":1,"SIMILARITY":1,"SEQUENCE CAUTION":2},"countByFeatureType":{"Chain":1,"Domain":1,"Binding site":1,"Natural variant":5},"uniParcId":"UPI000002C7DC"}},{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"P08780","uniProtkbId":"MOMPC_CHLTH","entryAudit":{"firstPublicDate":"1988-11-01","lastAnnotationUpdateDate":"2026-11-04","lastSequenceUpdateDate":"1988-11-01","entryVersion":82,"sequenceVersion":1},"annotationScore":3.0,"organism":{"scientificName":"Chlamydia trachomatis","taxonId":813,"lineage":["Bacteria","Pseudomonadati","Chlamydiota","Chlamydiia","Chlamydiales","Chlamydiaceae","Chlamydia/Chlamydophila group","Chlamydia"]},"proteinExistence":"2: Evidence at transcript level","proteinDescription":{"recommendedName":{"fullName":{"value":"Major outer membrane porin, serovar C"},"shortNames":[{"value":"MOMP"}]},"flag":"Precursor"},"genes":[{"geneName":{"value":"ompA"},"synonyms":[{"value":"omp1"},{"value":"omp1C"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250"}],"value":"In elementary bodies (EBs, the infectious stage, which is able to survive outside the host cell) provides the structural integrity of the outer envelope through disulfide cross-links with the small cysteine-rich protein and the large cysteine-rich periplasmic protein. It has been described in publications as the Sarkosyl-insoluble COMC (Chlamydia outer membrane complex), and serves as the functional equivalent of peptidoglycan (By similarity)"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250"}],"value":"Permits diffusion of specific solutes through the outer membrane"}],"commentType":"FUNCTION"},{"texts":[{"value":"Part of a disulfide cross-linked outer membrane complex (COMC) composed of the major outer membrane porin (MOMP), the small cysteine-rich protein (OmcA) and the large cysteine-rich periplasmic protein (OmcB)"}],"commentType":"SUBUNIT"},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000250"}],"value":"Cell outer membrane","id":"SL-0040"},"topology":{"evidences":[{"evidenceCode":"ECO:0000250"}],"value":"Multi-pass membrane protein","id":"SL-9909"}}]},{"texts":[{"value":"It is present but some of the disulfide bonds are reduced in reticulate bodies (RBs)"}],"commentType":"DEVELOPMENTAL STAGE"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Belongs to the chlamydial porin (CP) (TC 1.B.2) family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Signal","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":22,"modifier":"EXACT"}},"description":""},{"type":"Chain","location":{"start":{"value":23,"modifier":"EXACT"},"end":{"value":397,"modifier":"EXACT"}},"description":"Major outer membrane porin, serovar C","featureId":"PRO_0000020146"}],"keywords":[{"id":"KW-0998","category":"Cellular component","name":"Cell outer membrane"},{"id":"KW-0133","category":"Biological process","name":"Cell shape"},{"id":"KW-1015","category":"PTM","name":"Disulfide bond"},{"id":"KW-0406","category":"Biological process","name":"Ion transport"},{"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"id":"KW-0626","category":"Molecular function","name":"Porin"},{"id":"KW-0732","category":"Domain","name":"Signal"},{"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"id":"KW-1134","category":"Domain","name":"Transmembrane beta strand"},{"id":"KW-0813","category":"Biological process","name":"Transport"}],"references":[{"referenceNumber":1,"citation":{"id":"3040664","citationType":"journal article","authors":["Stephens R.S.","Sanchez-Pescador R.","Wagar E.A.","Inouye C.","Urdea M.S."],"citationCrossReferences":[{"database":"PubMed","id":"3040664"},{"database":"DOI","id":"10.1128/jb.169.9.3879-3885.1987"}],"title":"Diversity of Chlamydia trachomatis major outer membrane protein genes.","publicationDate":"1987","journal":"J. Bacteriol.","firstPage":"3879","lastPage":"3885","volume":"169"},"referencePositions":["NUCLEOTIDE SEQUENCE [GENOMIC DNA]"]},{"referenceNumber":2,"citation":{"id":"10950788","citationType":"journal article","authors":["Dean D.","Suchland R.J.","Stamm W.E."],"citationCrossReferences":[{"database":"PubMed","id":"10950788"},{"database":"DOI","id":"10.1086/315778"}],"title":"Evidence for long-term cervical persistence of Chlamydia trachomatis by omp1 genotyping.","publicationDate":"2000","journal":"J. Infect. Dis.","firstPage":"909","lastPage":"916","volume":"182"},"referencePositions":["NUCLEOTIDE SEQUENCE [GENOMIC DNA]"],"referenceComments":[{"value":"C/TW-3","type":"STRAIN"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"M17343","properties":[{"key":"ProteinId","value":"AAA23156.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AF202455","properties":[{"key":"ProteinId","value":"AAG09443.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"PIR","id":"S11011","properties":[{"key":"EntryName","value":"MMCWTC"}]},{"database":"AlphaFoldDB","id":"P08780","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"P08780","properties":[{"key":"Description","value":"-"}]},{"database":"GO","id":"GO:0009279","properties":[{"key":"GoTerm","value":"C:cell outer membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0015288","properties":[{"key":"GoTerm","value":"F:porin activity"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0005198","properties":[{"key":"GoTerm","value":"F:structural molecule activity"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"InterPro","id":"IPR000604","properties":[{"key":"EntryName","value":"Major_OMP_Chlamydia"}]},{"database":"Pfam","id":"PF01308","properties":[{"key":"EntryName","value":"Chlam_OMP"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR01334","properties":[{"key":"EntryName","value":"CHLAMIDIAOMP"}]}],"sequence":{"value":"MKKLLKSVLVFAALSSASSLQALPVGNPAEPSLMIDGILWEGFGGDPCDPCTTWCDAISMRVGYYGDFVFDRVLKTDVNKEFQMGAAPTTSDVAGLQNDPTINVARPNPAYGKHMQDAEMFTNAAYMALNIWDRFDVFCTLGATTGYLKGNSASFNLVGLFGTKTQSSSFNTAKLIPNTALNEAVVELYINTTFAWSVGARAALWECGCATLGASFQYAQSKPKVEELNVLCNASEFTINKPKGYVGAEFPLNITAGTEAATGTKDASIDYHEWQASLALSYRLNMFTPYIGVKWSRVSFDADTIRIAQPKLAEAILDVTTLNRTTAGKGSVVSAGTDNELADTMQIVSLQLNKMKSRKSCGIAVGTTIVDADKYAVTVEARLIDERAAHVNAQFRF","length":397,"molWeight":42893,"crc64":"0047BCDB108E5309","md5":"51485099CA4F1C8FBD6538769ABD67DB"},"extraAttributes":{"countByCommentType":{"FUNCTION":2,"SUBUNIT":1,"SUBCELLULAR LOCATION":1,"DEVELOPMENTAL STAGE":1,"SIMILARITY":1},"countByFeatureType":{"Signal":1,"Chain":1},"uniParcId":"UPI0000130C98"}},{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"P0DJI2","secondaryAccessions":["P18586","P21354"],"uniProtkbId":"OMCB_CHLTH","entryAudit":{"firstPublicDate":"2012-06-13","lastAnnotationUpdateDate":"2026-11-04","lastSequenceUpdateDate":"2012-06-13","entryVersion":39,"sequenceVersion":1},"annotationScore":3.0,"organism":{"scientificName":"Chlamydia trachomatis","taxonId":813,"lineage":["Bacteria","Pseudomonadati","Chlamydiota","Chlamydiia","Chlamydiales","Chlamydiaceae","Chlamydia/Chlamydophila group","Chlamydia"]},"proteinExistence":"2: Evidence at transcript level","proteinDescription":{"recommendedName":{"fullName":{"value":"Large cysteine-rich periplasmic protein OmcB, serovars L1/L3"},"shortNames":[{"value":"Large-CRP"}]},"alternativeNames":[{"fullName":{"value":"60 kDa CRP"}},{"fullName":{"value":"60 kDa outer membrane protein"}},{"fullName":{"value":"Cysteine-rich outer membrane protein"}}],"contains":[{"recommendedName":{"fullName":{"value":"Large cysteine-rich periplasmic protein OmcB, serovars L1/L3 isoform 1"}}},{"recommendedName":{"fullName":{"value":"Large cysteine-rich periplasmic protein OmcB, serovars L1/L3 isoform 2"}}}],"flag":"Precursor"},"genes":[{"geneName":{"value":"omcB"},"synonyms":[{"value":"omp2"},{"value":"omp2B"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250"}],"value":"In elementary bodies (EBs, the infectious stage, which is able to survive outside the host cell) provides the structural integrity of the outer envelope through disulfide cross-links with the small cysteine-rich protein and the major outer membrane protein. It has been described in publications as the Sarkosyl-insoluble COMC (Chlamydia outer membrane complex), and serves as the functional equivalent of peptidoglycan (By similarity)"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250"}],"value":"Part of a disulfide cross-linked outer membrane complex (COMC) composed of the major outer membrane porin (MOMP), the small cysteine-rich protein (OmcA) and the large cysteine-rich periplasmic protein (OmcB)"}],"commentType":"SUBUNIT"},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Periplasm","id":"SL-0200"}}]},{"texts":[{"value":"It is present but the disulfide bonds are reduced in the intracellular reticulate bodies (RBs)"}],"commentType":"DEVELOPMENTAL STAGE"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Was thought to be an outer membrane protein as it is part of a disulfide cross-linked complex that is insoluble in the detergent Sarkosyl; however based on experiments in C.psittaci it is likely to be periplasmic"}],"commentType":"CAUTION"},{"commentType":"SEQUENCE CAUTION","sequenceCautionType":"Erroneous initiation","sequence":"AAA23119.1","note":"Truncated N-terminus.","evidences":[{"evidenceCode":"ECO:0000305"}]}],"features":[{"type":"Signal","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":22,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Chain","location":{"start":{"value":23,"modifier":"EXACT"},"end":{"value":547,"modifier":"EXACT"}},"description":"Large cysteine-rich periplasmic protein OmcB, serovars L1/L3 isoform 1","featureId":"PRO_0000020174"},{"type":"Chain","location":{"start":{"value":41,"modifier":"EXACT"},"end":{"value":547,"modifier":"EXACT"}},"description":"Large cysteine-rich periplasmic protein OmcB, serovars L1/L3 isoform 2","featureId":"PRO_0000020175"},{"type":"Region","location":{"start":{"value":45,"modifier":"EXACT"},"end":{"value":84,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":52,"modifier":"EXACT"},"end":{"value":61,"modifier":"EXACT"}},"description":"Basic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]}],"keywords":[{"id":"KW-0133","category":"Biological process","name":"Cell shape"},{"id":"KW-1015","category":"PTM","name":"Disulfide bond"},{"id":"KW-0574","category":"Cellular component","name":"Periplasm"},{"id":"KW-0732","category":"Domain","name":"Signal"}],"references":[{"referenceNumber":1,"citation":{"id":"3066701","citationType":"journal article","authors":["Clarke I.N.","Ward M.E.","Lambden P.R."],"citationCrossReferences":[{"database":"PubMed","id":"3066701"},{"database":"DOI","id":"10.1016/0378-1119(88)90047-9"}],"title":"Molecular cloning and sequence analysis of a developmentally regulated cysteine-rich outer membrane protein from Chlamydia trachomatis.","publicationDate":"1988","journal":"Gene","firstPage":"307","lastPage":"314","volume":"71"},"referencePositions":["NUCLEOTIDE SEQUENCE [GENOMIC DNA]"],"referenceComments":[{"value":"L1/440/LN","type":"STRAIN"}]},{"referenceNumber":2,"citation":{"id":"1997423","citationType":"journal article","authors":["de la Maza L.M.","Fiedler T.J.","Carlson E.J.","Markoff B.A.","Peterson E.M."],"citationCrossReferences":[{"database":"PubMed","id":"1997423"},{"database":"DOI","id":"10.1128/iai.59.3.1196-1201.1991"}],"title":"Sequence diversity of the 60-kilodalton protein and of a putative 15-kilodalton protein between the trachoma and lymphogranuloma venereum biovars of Chlamydia trachomatis.","publicationDate":"1991","journal":"Infect. Immun.","firstPage":"1196","lastPage":"1201","volume":"59"},"referencePositions":["NUCLEOTIDE SEQUENCE [GENOMIC DNA]"],"referenceComments":[{"value":"L3/404","type":"STRAIN"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"M35148","properties":[{"key":"ProteinId","value":"AAA23119.1"},{"key":"Status","value":"ALT_INIT"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"X54390","properties":[{"key":"ProteinId","value":"CAA38261.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"PIR","id":"A32244","properties":[{"key":"EntryName","value":"A32244"}]},{"database":"AlphaFoldDB","id":"P0DJI2","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"P0DJI2","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"AATHMCV","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"GO","id":"GO:0042597","properties":[{"key":"GoTerm","value":"C:periplasmic space"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0005201","properties":[{"key":"GoTerm","value":"F:extracellular matrix structural constituent"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"Gene3D","id":"2.60.40.10","properties":[{"key":"EntryName","value":"Immunoglobulins"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR003506","properties":[{"key":"EntryName","value":"Chlam_OMP6"}]},{"database":"InterPro","id":"IPR051172","properties":[{"key":"EntryName","value":"Chlamydia_OmcB"}]},{"database":"InterPro","id":"IPR013783","properties":[{"key":"EntryName","value":"Ig-like_fold"}]},{"database":"InterPro","id":"IPR001434","properties":[{"key":"EntryName","value":"OmcB-like_DUF11"}]},{"database":"PANTHER","id":"PTHR34819","properties":[{"key":"EntryName","value":"LARGE CYSTEINE-RICH PERIPLASMIC PROTEIN OMCB"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR34819:SF4","properties":[{"key":"EntryName","value":"LARGE CYSTEINE-RICH PERIPLASMIC PROTEIN OMCB"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF03504","properties":[{"key":"EntryName","value":"Chlam_OMP6"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF01345","properties":[{"key":"EntryName","value":"CLIPPER"},{"key":"MatchStatus","value":"3"}]},{"database":"PRINTS","id":"PR01336","properties":[{"key":"EntryName","value":"CHLAMIDIAOM6"}]}],"sequence":{"value":"MNKLIRRAVTIFAVTSVASLFASGVLETSMAEFISTNVISLADTKAKDNTSHKSKKARKNHSKETPVNRKKVAPVHESKATGPKQDSCFGRMYTVKVNDDRNVEITQAVPKYATVGSPYPVEITATGKRDCVDVIITQQLPCEAEFVRSDPATTPTADGKLVWKIDRLGQGEKSKITVWVKPLKEGCCFTAATVCACPEIRSVTKCGQPAICVKQEGPENACLRCPVVYKINVVNQGTATARNVVVENPVPDSYAHSSGQRVLTFTLGDMQPGEHRTITVEFCPLKRGRATNIAMVSYCGGHKNTASVTTVINEPCVQVSIAGADWSYVCKPVEYVISVSNPGDLVLRDVVVKDTLSPGVTVLEAAGAQISCNKVVWTVKELNPGESLQYKVLVRAQTPGQFTNNVVVKSCSDCGTCTSCAEATTYWKGVAATHMCVVDTCDPVCVGENTVYRICVTNRGSAEDTNVSLMLKFSKELQPVSFSGPTKGTITGNTVVFDSLPRLGSKETVEFSVTLKAVSAGDARGEAILSSDTLTVPVSDTENTHIY","length":547,"molWeight":58782,"crc64":"78CEB41CCF98472D","md5":"36B06B9C494EAFB7C1EB503D61DA718A"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"SUBUNIT":1,"SUBCELLULAR LOCATION":1,"DEVELOPMENTAL STAGE":1,"CAUTION":1,"SEQUENCE CAUTION":1},"countByFeatureType":{"Signal":1,"Chain":2,"Region":1,"Compositional bias":1},"uniParcId":"UPI0000130CC8"}},{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"P0DPS5","secondaryAccessions":["O69196","Q9AMA4","Q9AMA5","Q9AMA6","Q9AMB2"],"uniProtkbId":"INCA_CHLTH","entryAudit":{"firstPublicDate":"2019-01-16","lastAnnotationUpdateDate":"2026-11-04","lastSequenceUpdateDate":"2019-01-16","entryVersion":16,"sequenceVersion":1},"annotationScore":3.0,"organism":{"scientificName":"Chlamydia trachomatis","taxonId":813,"lineage":["Bacteria","Pseudomonadati","Chlamydiota","Chlamydiia","Chlamydiales","Chlamydiaceae","Chlamydia/Chlamydophila group","Chlamydia"]},"proteinExistence":"3: Inferred from homology","proteinDescription":{"recommendedName":{"fullName":{"value":"Inclusion membrane protein A"}}},"genes":[{"geneName":{"value":"incA"}}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"A0A0H3MD02"}],"value":"Chlamydia replicate within a host intracellular vacuole, termed an inclusion. IncA is probably involved in the homotypic fusion of inclusions"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"A0A0H3MD02"}],"value":"Forms homooligomers"}],"commentType":"SUBUNIT"},{"commentType":"SUBCELLULAR LOCATION","note":{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"A0A0H3MD02"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9826388"},{"evidenceCode":"ECO:0000305","source":"PubMed","id":"11402010"}],"value":"Secreted, probably by a type III secretion system. Localized in the inclusion membrane (Probable) (PubMed:9826388). In the inclusion, the C-terminus faces the host cytosol (By similarity)"}]},"subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"A0A0H3MD02"}],"value":"Secreted","id":"SL-0243"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9826388"},{"evidenceCode":"ECO:0000305","source":"PubMed","id":"11402010"}],"value":"Host vacuole, host pathogen-containing vacuole, host pathogen-containing vacuole membrane","id":"SL-0509"},"topology":{"evidences":[{"evidenceCode":"ECO:0000255"}],"value":"Multi-pass membrane protein","id":"SL-9909"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"A0A0H3MD02"}],"value":"IncA proteins share the same general organization: a short N-terminal domain, a large bilobed hydrophobic domain, and a C-terminal cytoplasmic domain"}],"commentType":"DOMAIN"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Belongs to the IncA family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":273,"modifier":"EXACT"}},"description":"Inclusion membrane protein A","featureId":"PRO_0000084197"},{"type":"Transmembrane","location":{"start":{"value":41,"modifier":"EXACT"},"end":{"value":61,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":64,"modifier":"EXACT"},"end":{"value":84,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Region","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":20,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":254,"modifier":"EXACT"},"end":{"value":273,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Coiled coil","location":{"start":{"value":170,"modifier":"EXACT"},"end":{"value":233,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Compositional bias","location":{"start":{"value":254,"modifier":"EXACT"},"end":{"value":273,"modifier":"EXACT"}},"description":"Polar residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Natural variant","location":{"start":{"value":200,"modifier":"EXACT"},"end":{"value":200,"modifier":"EXACT"}},"description":"in strain: L1/440-L","featureId":"","alternativeSequence":{"originalSequence":"R","alternativeSequences":["C"]}},{"type":"Natural variant","location":{"start":{"value":235,"modifier":"EXACT"},"end":{"value":235,"modifier":"EXACT"}},"description":"in strain: L1/440/LN and B/Tw-5/OT","featureId":"","alternativeSequence":{"originalSequence":"R","alternativeSequences":["K"]}}],"keywords":[{"id":"KW-0175","category":"Domain","name":"Coiled coil"},{"id":"KW-1043","category":"Cellular component","name":"Host membrane"},{"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"id":"KW-0964","category":"Cellular component","name":"Secreted"},{"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"id":"KW-1133","category":"Domain","name":"Transmembrane helix"},{"id":"KW-0843","category":"Biological process","name":"Virulence"}],"references":[{"referenceNumber":1,"citation":{"id":"11402010","citationType":"journal article","authors":["Pannekoek Y.","van der Ende A.","Eijk P.P.","van Marle J.","de Witte M.A.","Ossewaarde J.M.","van den Brule A.J.C.","Morre S.A.","Dankert J."],"citationCrossReferences":[{"database":"PubMed","id":"11402010"},{"database":"DOI","id":"10.1128/iai.69.7.4654-4656.2001"}],"title":"Normal IncA expression and fusogenicity of inclusions in Chlamydia trachomatis isolates with the incA I47T mutation.","publicationDate":"2001","journal":"Infect. Immun.","firstPage":"4654","lastPage":"4656","volume":"69"},"referencePositions":["NUCLEOTIDE SEQUENCE [GENOMIC DNA]","SUBCELLULAR LOCATION"],"referenceComments":[{"value":"B/Tw-5/OT","type":"STRAIN"},{"value":"L1/440/LN","type":"STRAIN"},{"value":"L3/404","type":"STRAIN"}]},{"referenceNumber":2,"citation":{"id":"9826388","citationType":"journal article","authors":["Bannantine J.P.","Stamm W.E.","Suchland R.J.","Rockey D.D."],"citationCrossReferences":[{"database":"PubMed","id":"9826388"},{"database":"DOI","id":"10.1128/iai.66.12.6017-6021.1998"}],"title":"Chlamydia trachomatis IncA is localized to the inclusion membrane and is recognized by antisera from infected humans and primates.","publicationDate":"1998","journal":"Infect. Immun.","firstPage":"6017","lastPage":"6021","volume":"66"},"referencePositions":["SUBCELLULAR LOCATION"],"referenceComments":[{"value":"A/G-17/OT","type":"STRAIN"},{"value":"B/Tw-5/OT","type":"STRAIN"},{"value":"Ba/Ap-2/OT","type":"STRAIN"},{"value":"C/TW-3/OT","type":"STRAIN"},{"value":"D-/MT 157/Cx","type":"STRAIN"},{"value":"Da/TW-448/Cx","type":"STRAIN"},{"value":"E/UW-5/Cx","type":"STRAIN"},{"value":"F/UW-6/Cx","type":"STRAIN"},{"value":"G/UW-57/Cx","type":"STRAIN"},{"value":"H/UW-4/Cx","type":"STRAIN"},{"value":"I-/MT 518/Cx","type":"STRAIN"},{"value":"I/UW-12/Ur","type":"STRAIN"},{"value":"Ia/UW-202/NP","type":"STRAIN"},{"value":"J/UW-36/Cx","type":"STRAIN"},{"value":"K/UW-31/Cx","type":"STRAIN"},{"value":"L1/440/Bu","type":"STRAIN"},{"value":"L2a/UW-396/Bu","type":"STRAIN"},{"value":"L3/404/Bu","type":"STRAIN"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AF327008","properties":[{"key":"ProteinId","value":"AAG61105.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AF327010","properties":[{"key":"ProteinId","value":"AAG61107.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AF326993","properties":[{"key":"ProteinId","value":"AAG61090.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"AlphaFoldDB","id":"P0DPS5","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"P0DPS5","properties":[{"key":"Description","value":"-"}]},{"database":"GO","id":"GO:0005576","properties":[{"key":"GoTerm","value":"C:extracellular region"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0140221","properties":[{"key":"GoTerm","value":"C:pathogen-containing vacuole membrane"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"9826388"}]}],"sequence":{"value":"MTTPTLIVTPPSPPAPSYSANRVPQPSLMDKIKKIAAIASLILIGTIGFLALLGHLVGFLIAPQITIVLLALFITSLAGNALYLQKTANLHLYQDLQREVGSLKEINFMLSVLQKEFLHLSKEFATTSKDLSAVSQDFYSCLQGFRDNYKGFESLLDEYKNSTEEMRKLFSQEIIADLKSSVASLREEIRFLTPLAEEVRRLAHNRESLTAAIEELKTIRDSLRDEIGQLSQLSRTLTSQIALQRKESSDLCSQIRETLSSPRKSASPSTKSS","length":273,"molWeight":30346,"crc64":"7E9F9569405E5469","md5":"0238CE00F0E9B96F01CA65AA024C61F9"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"SUBUNIT":1,"SUBCELLULAR LOCATION":1,"DOMAIN":1,"SIMILARITY":1},"countByFeatureType":{"Chain":1,"Transmembrane":2,"Region":2,"Coiled coil":1,"Compositional bias":1,"Natural variant":2},"uniParcId":"UPI00000B710B"}},{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"P13467","uniProtkbId":"MOMPH_CHLTH","entryAudit":{"firstPublicDate":"1990-01-01","lastAnnotationUpdateDate":"2026-11-04","lastSequenceUpdateDate":"1991-02-01","entryVersion":79,"sequenceVersion":2},"annotationScore":3.0,"organism":{"scientificName":"Chlamydia trachomatis","taxonId":813,"lineage":["Bacteria","Pseudomonadati","Chlamydiota","Chlamydiia","Chlamydiales","Chlamydiaceae","Chlamydia/Chlamydophila group","Chlamydia"]},"proteinExistence":"2: Evidence at transcript level","proteinDescription":{"recommendedName":{"fullName":{"value":"Major outer membrane porin, serovar H"},"shortNames":[{"value":"MOMP"}]},"flag":"Precursor"},"genes":[{"geneName":{"value":"ompA"},"synonyms":[{"value":"omp1H"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250"}],"value":"In elementary bodies (EBs, the infectious stage, which is able to survive outside the host cell) provides the structural integrity of the outer envelope through disulfide cross-links with the small cysteine-rich protein and the large cysteine-rich periplasmic protein. It has been described in publications as the Sarkosyl-insoluble COMC (Chlamydia outer membrane complex), and serves as the functional equivalent of peptidoglycan (By similarity)"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250"}],"value":"Permits diffusion of specific solutes through the outer membrane"}],"commentType":"FUNCTION"},{"texts":[{"value":"Part of a disulfide cross-linked outer membrane complex (COMC) composed of the major outer membrane porin (MOMP), the small cysteine-rich protein (OmcA) and the large cysteine-rich periplasmic protein (OmcB)"}],"commentType":"SUBUNIT"},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000250"}],"value":"Cell outer membrane","id":"SL-0040"},"topology":{"evidences":[{"evidenceCode":"ECO:0000250"}],"value":"Multi-pass membrane protein","id":"SL-9909"}}]},{"texts":[{"value":"It is present but some of the disulfide bonds are reduced in reticulate bodies (RBs)"}],"commentType":"DEVELOPMENTAL STAGE"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Belongs to the chlamydial porin (CP) (TC 1.B.2) family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Signal","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":22,"modifier":"EXACT"}},"description":""},{"type":"Chain","location":{"start":{"value":23,"modifier":"EXACT"},"end":{"value":397,"modifier":"EXACT"}},"description":"Major outer membrane porin, serovar H","featureId":"PRO_0000020150"}],"keywords":[{"id":"KW-0998","category":"Cellular component","name":"Cell outer membrane"},{"id":"KW-0133","category":"Biological process","name":"Cell shape"},{"id":"KW-1015","category":"PTM","name":"Disulfide bond"},{"id":"KW-0406","category":"Biological process","name":"Ion transport"},{"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"id":"KW-0626","category":"Molecular function","name":"Porin"},{"id":"KW-0732","category":"Domain","name":"Signal"},{"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"id":"KW-1134","category":"Domain","name":"Transmembrane beta strand"},{"id":"KW-0813","category":"Biological process","name":"Transport"}],"references":[{"referenceNumber":1,"citation":{"id":"2813066","citationType":"journal article","authors":["Hamilton P.T.","Malinowski D.P."],"citationCrossReferences":[{"database":"PubMed","id":"2813066"},{"database":"DOI","id":"10.1093/nar/17.20.8366"}],"title":"Nucleotide sequence of the major outer membrane protein gene from Chlamydia trachomatis serovar H.","publicationDate":"1989","journal":"Nucleic Acids Res.","firstPage":"8366","lastPage":"8366","volume":"17"},"referencePositions":["NUCLEOTIDE SEQUENCE [GENOMIC DNA]"],"referenceComments":[{"value":"Serovar H","type":"STRAIN"}]},{"referenceNumber":2,"citation":{"id":"CI-F3RK4CHGQFE9B","citationType":"submission","authors":["Dean D.A."],"title":"Sequence analysis of the major outer membrane protein gene (ompA) of Chlamydia trachomatis.","publicationDate":"SEP-2000","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [GENOMIC DNA]"],"referenceComments":[{"value":"H/UW-4","type":"STRAIN"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"X16007","properties":[{"key":"ProteinId","value":"CAA34145.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AF304857","properties":[{"key":"ProteinId","value":"AAG41415.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"PIR","id":"S06589","properties":[{"key":"EntryName","value":"MMCWTH"}]},{"database":"RefSeq","id":"WP_100139615.1","properties":[{"key":"NucleotideSequenceId","value":"NZ_CP017732.1"}]},{"database":"AlphaFoldDB","id":"P13467","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"P13467","properties":[{"key":"Description","value":"-"}]},{"database":"GO","id":"GO:0009279","properties":[{"key":"GoTerm","value":"C:cell outer membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0015288","properties":[{"key":"GoTerm","value":"F:porin activity"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0005198","properties":[{"key":"GoTerm","value":"F:structural molecule activity"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"InterPro","id":"IPR000604","properties":[{"key":"EntryName","value":"Major_OMP_Chlamydia"}]},{"database":"Pfam","id":"PF01308","properties":[{"key":"EntryName","value":"Chlam_OMP"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR01334","properties":[{"key":"EntryName","value":"CHLAMIDIAOMP"}]}],"sequence":{"value":"MKKLLKSVLVFAALSSASSLQALPVGNPAEPSLMIDGILWEGFGGDPCDPCATWCDAISMRVGYYGDFVFDRVLKTDVNKEFQMGAAPTTNDAADLQNDPKTNVARPNPAYGKHMQDAEMFTNAAYMALNIWDRFDVFCTLGATTGYLKGNSASFNLVGLFGTKTKSSDFNTAKLVPNIALNRAVVELYTDTTFAWSVGARAALWECGCATLGASFQYAQSKPKVEELNVLCNASEFTINKPKGYVGAEFPLDITAGTEAATGTKDASIDYHEWQASLALSYRLNMFTPYIGVKWSRVSFDADTIRIAQPKLAEAILDVTTLNPTIAGKGTVVASGSDNDLADTMQIVSLQLNKMKSRKSCGIAVGTTIVDADKYAVTVETRLIDERAAHVNAQFRF","length":397,"molWeight":42947,"crc64":"478ACE3808BF37BA","md5":"07BA6813BE2F7F3F241A0BF99A9204A4"},"extraAttributes":{"countByCommentType":{"FUNCTION":2,"SUBUNIT":1,"SUBCELLULAR LOCATION":1,"DEVELOPMENTAL STAGE":1,"SIMILARITY":1},"countByFeatureType":{"Signal":1,"Chain":1},"uniParcId":"UPI0000130C9C"}},{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"P19542","uniProtkbId":"MOMPL_CHLTH","entryAudit":{"firstPublicDate":"1991-02-01","lastAnnotationUpdateDate":"2026-11-04","lastSequenceUpdateDate":"1991-02-01","entryVersion":75,"sequenceVersion":1},"annotationScore":3.0,"organism":{"scientificName":"Chlamydia trachomatis","taxonId":813,"lineage":["Bacteria","Pseudomonadati","Chlamydiota","Chlamydiia","Chlamydiales","Chlamydiaceae","Chlamydia/Chlamydophila group","Chlamydia"]},"proteinExistence":"2: Evidence at transcript level","proteinDescription":{"recommendedName":{"fullName":{"value":"Major outer membrane porin, serovar L1"},"shortNames":[{"value":"MOMP"}]},"flag":"Precursor"},"genes":[{"geneName":{"value":"ompA"},"synonyms":[{"value":"omp1L1"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250"}],"value":"In elementary bodies (EBs, the infectious stage, which is able to survive outside the host cell) provides the structural integrity of the outer envelope through disulfide cross-links with the small cysteine-rich protein and the large cysteine-rich periplasmic protein. It has been described in publications as the Sarkosyl-insoluble COMC (Chlamydia outer membrane complex), and serves as the functional equivalent of peptidoglycan (By similarity)"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250"}],"value":"Permits diffusion of specific solutes through the outer membrane"}],"commentType":"FUNCTION"},{"texts":[{"value":"Part of a disulfide cross-linked outer membrane complex (COMC) composed of the major outer membrane porin (MOMP), the small cysteine-rich protein (OmcA) and the large cysteine-rich periplasmic protein (OmcB)"}],"commentType":"SUBUNIT"},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000250"}],"value":"Cell outer membrane","id":"SL-0040"},"topology":{"evidences":[{"evidenceCode":"ECO:0000250"}],"value":"Multi-pass membrane protein","id":"SL-9909"}}]},{"texts":[{"value":"It is present but some of the disulfide bonds are reduced in reticulate bodies (RBs)"}],"commentType":"DEVELOPMENTAL STAGE"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Belongs to the chlamydial porin (CP) (TC 1.B.2) family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Signal","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":22,"modifier":"EXACT"}},"description":""},{"type":"Chain","location":{"start":{"value":23,"modifier":"EXACT"},"end":{"value":393,"modifier":"EXACT"}},"description":"Major outer membrane porin, serovar L1","featureId":"PRO_0000020151"}],"keywords":[{"id":"KW-0998","category":"Cellular component","name":"Cell outer membrane"},{"id":"KW-0133","category":"Biological process","name":"Cell shape"},{"id":"KW-1015","category":"PTM","name":"Disulfide bond"},{"id":"KW-0406","category":"Biological process","name":"Ion transport"},{"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"id":"KW-0626","category":"Molecular function","name":"Porin"},{"id":"KW-0732","category":"Domain","name":"Signal"},{"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"id":"KW-1134","category":"Domain","name":"Transmembrane beta strand"},{"id":"KW-0813","category":"Biological process","name":"Transport"}],"references":[{"referenceNumber":1,"citation":{"id":"CI-APGCOMUJ9H0O0","citationType":"journal article","authors":["Pickett M.A.","Ward M.E.","Clarke I.N."],"title":"Complete nucleotide sequence of the major outer membrane protein gene from Chlamydia trachomatis serovar L1.","publicationDate":"1987","journal":"FEMS Microbiol. Lett.","firstPage":"185","lastPage":"190","volume":"42"},"referencePositions":["NUCLEOTIDE SEQUENCE [GENOMIC DNA]"]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"M36533","properties":[{"key":"ProteinId","value":"AAA23142.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"PIR","id":"S06259","properties":[{"key":"EntryName","value":"S06259"}]},{"database":"RefSeq","id":"WP_015505913.1","properties":[{"key":"NucleotideSequenceId","value":"NZ_CP142852.1"}]},{"database":"AlphaFoldDB","id":"P19542","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"P19542","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"AAHMNAQ","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"GO","id":"GO:0009279","properties":[{"key":"GoTerm","value":"C:cell outer membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0015288","properties":[{"key":"GoTerm","value":"F:porin activity"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0005198","properties":[{"key":"GoTerm","value":"F:structural molecule activity"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"InterPro","id":"IPR000604","properties":[{"key":"EntryName","value":"Major_OMP_Chlamydia"}]},{"database":"Pfam","id":"PF01308","properties":[{"key":"EntryName","value":"Chlam_OMP"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR01334","properties":[{"key":"EntryName","value":"CHLAMIDIAOMP"}]}],"sequence":{"value":"MKKLLKSVLVFAALSSASSLQALPVGNPAEPSLMIDGILWEGFGGDPCDPCTTWCDAISMRMGYYGDFVFDRVLQTDVNKEFQMGAKPTATTGNAAAPSTCTARENPAYGRHMQDAEMFTNAAYMALNIWDRFDVFCTLGATSGYLKGNSASFNLVGLFGDNENQSTVKKDAVPNMSFDQSVVELYTDTTFAWSVGARAALWECGCATLGASFQYAQSKPKVEELNVLCNAAEFTINKPKGYVGKEFPLDLTAGTDAATGTKDASIDYHEWQASLALSYRLNMFTPYIGVKWSRASFDADTIRIAQPKLATAIFDTTTLNPTIAGAGEVKANAEGQLGDTMQIVSLQLNKMKSRKSCGIAVGTTIVDADKYAVTVETRLIDERAAHVNAQFRF","length":393,"molWeight":42543,"crc64":"7A952839408EE2DF","md5":"B31E4F95C510252A40BC11B9D633F86F"},"extraAttributes":{"countByCommentType":{"FUNCTION":2,"SUBUNIT":1,"SUBCELLULAR LOCATION":1,"DEVELOPMENTAL STAGE":1,"SIMILARITY":1},"countByFeatureType":{"Signal":1,"Chain":1},"uniParcId":"UPI0000130C9E"}},{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"P23421","uniProtkbId":"MOMPB_CHLTH","entryAudit":{"firstPublicDate":"1991-11-01","lastAnnotationUpdateDate":"2026-11-04","lastSequenceUpdateDate":"1991-11-01","entryVersion":78,"sequenceVersion":1},"annotationScore":3.0,"organism":{"scientificName":"Chlamydia trachomatis","taxonId":813,"lineage":["Bacteria","Pseudomonadati","Chlamydiota","Chlamydiia","Chlamydiales","Chlamydiaceae","Chlamydia/Chlamydophila group","Chlamydia"]},"proteinExistence":"2: Evidence at transcript level","proteinDescription":{"recommendedName":{"fullName":{"value":"Major outer membrane porin, serovar B"},"shortNames":[{"value":"MOMP"}]},"flag":"Precursor"},"genes":[{"geneName":{"value":"ompA"},"synonyms":[{"value":"omp1B"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250"}],"value":"In elementary bodies (EBs, the infectious stage, which is able to survive outside the host cell) provides the structural integrity of the outer envelope through disulfide cross-links with the small cysteine-rich protein and the large cysteine-rich periplasmic protein. It has been described in publications as the Sarkosyl-insoluble COMC (Chlamydia outer membrane complex), and serves as the functional equivalent of peptidoglycan (By similarity)"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250"}],"value":"Permits diffusion of specific solutes through the outer membrane"}],"commentType":"FUNCTION"},{"texts":[{"value":"Part of a disulfide cross-linked outer membrane complex (COMC) composed of the major outer membrane porin (MOMP), the small cysteine-rich protein (OmcA) and the large cysteine-rich periplasmic protein (OmcB)"}],"commentType":"SUBUNIT"},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000250"}],"value":"Cell outer membrane","id":"SL-0040"},"topology":{"evidences":[{"evidenceCode":"ECO:0000250"}],"value":"Multi-pass membrane protein","id":"SL-9909"}}]},{"texts":[{"value":"It is present but some of the disulfide bonds are reduced in reticulate bodies (RBs)"}],"commentType":"DEVELOPMENTAL STAGE"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Belongs to the chlamydial porin (CP) (TC 1.B.2) family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Signal","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":22,"modifier":"EXACT"}},"description":""},{"type":"Chain","location":{"start":{"value":23,"modifier":"EXACT"},"end":{"value":394,"modifier":"EXACT"}},"description":"Major outer membrane porin, serovar B","featureId":"PRO_0000020145"}],"keywords":[{"id":"KW-0998","category":"Cellular component","name":"Cell outer membrane"},{"id":"KW-0133","category":"Biological process","name":"Cell shape"},{"id":"KW-1015","category":"PTM","name":"Disulfide bond"},{"id":"KW-0406","category":"Biological process","name":"Ion transport"},{"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"id":"KW-0626","category":"Molecular function","name":"Porin"},{"id":"KW-0732","category":"Domain","name":"Signal"},{"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"id":"KW-1134","category":"Domain","name":"Transmembrane beta strand"},{"id":"KW-0813","category":"Biological process","name":"Transport"}],"references":[{"referenceNumber":1,"citation":{"id":"3040664","citationType":"journal article","authors":["Stephens R.S.","Sanchez-Pescador R.","Wagar E.A.","Inouye C.","Urdea M.S."],"citationCrossReferences":[{"database":"PubMed","id":"3040664"},{"database":"DOI","id":"10.1128/jb.169.9.3879-3885.1987"}],"title":"Diversity of Chlamydia trachomatis major outer membrane protein genes.","publicationDate":"1987","journal":"J. Bacteriol.","firstPage":"3879","lastPage":"3885","volume":"169"},"referencePositions":["NUCLEOTIDE SEQUENCE [GENOMIC DNA]"]},{"referenceNumber":2,"citation":{"id":"CI-F3RK4CHGQFE9B","citationType":"submission","authors":["Dean D.A."],"title":"Sequence analysis of the major outer membrane protein gene (ompA) of Chlamydia trachomatis.","publicationDate":"SEP-2000","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [GENOMIC DNA]"],"referenceComments":[{"value":"B/Tw-5/OT","type":"STRAIN"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"M17342","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AF304856","properties":[{"key":"ProteinId","value":"AAG41414.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"PIR","id":"S11010","properties":[{"key":"EntryName","value":"MMCWTB"}]},{"database":"AlphaFoldDB","id":"P23421","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"P23421","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"AAHMNAQ","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"GO","id":"GO:0009279","properties":[{"key":"GoTerm","value":"C:cell outer membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0015288","properties":[{"key":"GoTerm","value":"F:porin activity"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0005198","properties":[{"key":"GoTerm","value":"F:structural molecule activity"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"InterPro","id":"IPR000604","properties":[{"key":"EntryName","value":"Major_OMP_Chlamydia"}]},{"database":"Pfam","id":"PF01308","properties":[{"key":"EntryName","value":"Chlam_OMP"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR01334","properties":[{"key":"EntryName","value":"CHLAMIDIAOMP"}]}],"sequence":{"value":"MKKLLKSVLVFAALSSASSLQALPVGNPAEPSLMIDGILWEGFGGDPCDPCTTWVDAISMRMGYYGDFVFDRVLKTDVNKEFQMGAKPTTTTGNAVAPSTLTARENPAYGRHMQDAEMFTNAACMALNIWDRFDVFCTLGASSGYLKGNSASFNLVGLFGNNENQTKVSNGAFVPNMSLDQSVVELYTDTAFAWSVGARAALWECGCATLGASFQYAQSKPKVEELNVLCNAAEFTINKPKGYVGKELPLDLTAGTDAATGTKDASIDYHEWQASLALSYRLNMFTPYIGVKWSRASFDADTIRIAQPKSAETIFDVTTLNPTIAGAGDVKTSAEGQLGDTMQIVSLQLNKMKSRKSCGIAVGTTIVDADKYAVTVETRLIDERAAHVNAQFRF","length":394,"molWeight":42528,"crc64":"C364233145A69301","md5":"4B90EE2437FAFCCFD176DFFF4C18D0CF"},"extraAttributes":{"countByCommentType":{"FUNCTION":2,"SUBUNIT":1,"SUBCELLULAR LOCATION":1,"DEVELOPMENTAL STAGE":1,"SIMILARITY":1},"countByFeatureType":{"Signal":1,"Chain":1},"uniParcId":"UPI0000130C97"}},{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"Q548P6","uniProtkbId":"OMCBH_CHLTH","entryAudit":{"firstPublicDate":"2006-09-05","lastAnnotationUpdateDate":"2026-11-04","lastSequenceUpdateDate":"2005-05-24","entryVersion":60,"sequenceVersion":1},"annotationScore":3.0,"organism":{"scientificName":"Chlamydia trachomatis","taxonId":813,"lineage":["Bacteria","Pseudomonadati","Chlamydiota","Chlamydiia","Chlamydiales","Chlamydiaceae","Chlamydia/Chlamydophila group","Chlamydia"]},"proteinExistence":"3: Inferred from homology","proteinDescription":{"recommendedName":{"fullName":{"value":"Large cysteine-rich periplasmic protein OmcB, serovars D/H/G/K"},"shortNames":[{"value":"Large-CRP"}]},"alternativeNames":[{"fullName":{"value":"60 kDa CRP"}},{"fullName":{"value":"60 kDa outer membrane protein"}},{"fullName":{"value":"Cysteine-rich outer membrane protein"}}],"flag":"Precursor"},"genes":[{"geneName":{"value":"omcB"},"synonyms":[{"value":"ompA"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250"}],"value":"In elementary bodies (EBs, the infectious stage, which is able to survive outside the host cell) provides the structural integrity of the outer envelope through disulfide cross-links with the small cysteine-rich protein and the major outer membrane porin. It has been described in publications as the Sarkosyl-insoluble COMC (Chlamydia outer membrane complex), and serves as the functional equivalent of peptidoglycan. It is present but the disulfide bonds are reduced in reticulate bodies (RBs) (By similarity)"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250"}],"value":"Part of a disulfide cross-linked outer membrane complex (COMC) composed of the major outer membrane porin (MOMP), the small cysteine-rich protein (OmcA) and the large cysteine-rich periplasmic protein (OmcB)"}],"commentType":"SUBUNIT"},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Periplasm","id":"SL-0200"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Was thought to be an outer membrane protein as it is part of a disulfide cross-linked complex that is insoluble in the detergent Sarkosyl; however based on experiments in C.psittaci it is likely to be periplasmic"}],"commentType":"CAUTION"}],"features":[{"type":"Signal","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":22,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Propeptide","location":{"start":{"value":23,"modifier":"EXACT"},"end":{"value":40,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000255"}],"featureId":"PRO_0000248873"},{"type":"Chain","location":{"start":{"value":41,"modifier":"EXACT"},"end":{"value":547,"modifier":"EXACT"}},"description":"Large cysteine-rich periplasmic protein OmcB, serovars D/H/G/K","featureId":"PRO_0000248874"},{"type":"Region","location":{"start":{"value":45,"modifier":"EXACT"},"end":{"value":84,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":52,"modifier":"EXACT"},"end":{"value":61,"modifier":"EXACT"}},"description":"Basic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":62,"modifier":"EXACT"},"end":{"value":79,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]}],"keywords":[{"id":"KW-0133","category":"Biological process","name":"Cell shape"},{"id":"KW-1015","category":"PTM","name":"Disulfide bond"},{"id":"KW-0574","category":"Cellular component","name":"Periplasm"},{"id":"KW-0732","category":"Domain","name":"Signal"}],"references":[{"referenceNumber":1,"citation":{"id":"11567000","citationType":"journal article","authors":["Millman K.L.","Tavare S.","Dean D."],"citationCrossReferences":[{"database":"PubMed","id":"11567000"},{"database":"DOI","id":"10.1128/jb.183.20.5997-6008.2001"}],"title":"Recombination in the ompA gene but not the omcB gene of Chlamydia contributes to serovar-specific differences in tissue tropism, immune surveillance, and persistence of the organism.","publicationDate":"2001","journal":"J. Bacteriol.","firstPage":"5997","lastPage":"6008","volume":"183"},"referencePositions":["NUCLEOTIDE SEQUENCE [GENOMIC DNA]"],"referenceComments":[{"value":"D/UW-3","type":"STRAIN"},{"value":"G/UW-57","type":"STRAIN"},{"value":"H/UW-4","type":"STRAIN"},{"value":"K/UW-31","type":"STRAIN"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AF304327","properties":[{"key":"ProteinId","value":"AAL14097.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AF304328","properties":[{"key":"ProteinId","value":"AAL14098.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AF304331","properties":[{"key":"ProteinId","value":"AAL14101.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AF304326","properties":[{"key":"ProteinId","value":"AAL14096.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"AlphaFoldDB","id":"Q548P6","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"AATHMCV","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"GO","id":"GO:0042597","properties":[{"key":"GoTerm","value":"C:periplasmic space"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0005201","properties":[{"key":"GoTerm","value":"F:extracellular matrix structural constituent"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"Gene3D","id":"2.60.40.10","properties":[{"key":"EntryName","value":"Immunoglobulins"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR003506","properties":[{"key":"EntryName","value":"Chlam_OMP6"}]},{"database":"InterPro","id":"IPR051172","properties":[{"key":"EntryName","value":"Chlamydia_OmcB"}]},{"database":"InterPro","id":"IPR047589","properties":[{"key":"EntryName","value":"DUF11_rpt"}]},{"database":"InterPro","id":"IPR013783","properties":[{"key":"EntryName","value":"Ig-like_fold"}]},{"database":"InterPro","id":"IPR001434","properties":[{"key":"EntryName","value":"OmcB-like_DUF11"}]},{"database":"NCBIfam","id":"TIGR01451","properties":[{"key":"EntryName","value":"B_ant_repeat"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR34819","properties":[{"key":"EntryName","value":"LARGE CYSTEINE-RICH PERIPLASMIC PROTEIN OMCB"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR34819:SF4","properties":[{"key":"EntryName","value":"LARGE CYSTEINE-RICH PERIPLASMIC PROTEIN OMCB"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF03504","properties":[{"key":"EntryName","value":"Chlam_OMP6"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF01345","properties":[{"key":"EntryName","value":"CLIPPER"},{"key":"MatchStatus","value":"3"}]},{"database":"PRINTS","id":"PR01336","properties":[{"key":"EntryName","value":"CHLAMIDIAOM6"}]}],"sequence":{"value":"MNKLIRRAVTIFAVTSVASLFASGVLETSMAESLSTNVISLADTKAKDNTSHKSKKARKNHSKETPVDRKEVAPVHESKATGPKQDSCFGRMYTVKVNDDRNVEITQAVPEYATVGSPYPIEITATGKRDCVDVIITQQLPCEAEFVRSDPATTPTADGKLVWKIDRLGQGEKSKITVWVKPLKEGCCFTAATVCACPEIRSVTKCGQPAICVKQEGPENACLRCPVVYKINIVNQGTATARNVVVENPVPDGYAHSSGQRVLTFTLGDMQPGEHRTITVEFCPLKRGRATNIATVSYCGGHKNTASVTTVINEPCVQVSIAGADWSYVCKPVEYVISVSNPGDLVLRDVVVEDTLSPGVTVLEAAGAQISCNKVVWTVKELNPGESLQYKVLVRAQTPGQFTNNVVVKSCSDCGTCTSCAEATTYWKGVAATHMCVVDTCDPVCVGENTVYRICVTNRGSAEDTNVSLMLKFSKELQPVSFSGPTKGTITGNTVVFDSLPRLGSKETVEFSVTLKAVSAGDARGEAILSSDTLTVPVSDTENTHIY","length":547,"molWeight":58694,"crc64":"42719B4BDCEDCCEA","md5":"2B6396AF300E0886C6B2B34F19353E59"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"SUBUNIT":1,"SUBCELLULAR LOCATION":1,"CAUTION":1},"countByFeatureType":{"Signal":1,"Propeptide":1,"Chain":1,"Region":1,"Compositional bias":2},"uniParcId":"UPI0000000D05"}},{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"P17451","uniProtkbId":"MOMPE_CHLTH","entryAudit":{"firstPublicDate":"1990-08-01","lastAnnotationUpdateDate":"2026-11-04","lastSequenceUpdateDate":"1990-08-01","entryVersion":91,"sequenceVersion":1},"annotationScore":3.0,"organism":{"scientificName":"Chlamydia trachomatis","taxonId":813,"lineage":["Bacteria","Pseudomonadati","Chlamydiota","Chlamydiia","Chlamydiales","Chlamydiaceae","Chlamydia/Chlamydophila group","Chlamydia"]},"proteinExistence":"2: Evidence at transcript level","proteinDescription":{"recommendedName":{"fullName":{"value":"Major outer membrane porin, serovar E"},"shortNames":[{"value":"MOMP"}]},"flag":"Precursor"},"genes":[{"geneName":{"value":"ompA"},"synonyms":[{"value":"omp1E"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250"}],"value":"In elementary bodies (EBs, the infectious stage, which is able to survive outside the host cell) provides the structural integrity of the outer envelope through disulfide cross-links with the small cysteine-rich protein and the large cysteine-rich periplasmic protein. It has been described in publications as the Sarkosyl-insoluble COMC (Chlamydia outer membrane complex), and serves as the functional equivalent of peptidoglycan (By similarity)"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250"}],"value":"Permits diffusion of specific solutes through the outer membrane"}],"commentType":"FUNCTION"},{"texts":[{"value":"Part of a disulfide cross-linked outer membrane complex (COMC) composed of the major outer membrane porin (MOMP), the small cysteine-rich protein (OmcA) and the large cysteine-rich periplasmic protein (OmcB)"}],"commentType":"SUBUNIT"},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000250"}],"value":"Cell outer membrane","id":"SL-0040"},"topology":{"evidences":[{"evidenceCode":"ECO:0000250"}],"value":"Multi-pass membrane protein","id":"SL-9909"}}]},{"texts":[{"value":"It is present but some of the disulfide bonds are reduced in reticulate bodies (RBs)"}],"commentType":"DEVELOPMENTAL STAGE"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Belongs to the chlamydial porin (CP) (TC 1.B.2) family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Signal","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":22,"modifier":"EXACT"}},"description":""},{"type":"Chain","location":{"start":{"value":23,"modifier":"EXACT"},"end":{"value":393,"modifier":"EXACT"}},"description":"Major outer membrane porin, serovar E","featureId":"PRO_0000020148"}],"keywords":[{"id":"KW-0998","category":"Cellular component","name":"Cell outer membrane"},{"id":"KW-0133","category":"Biological process","name":"Cell shape"},{"id":"KW-1015","category":"PTM","name":"Disulfide bond"},{"id":"KW-0406","category":"Biological process","name":"Ion transport"},{"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"id":"KW-0626","category":"Molecular function","name":"Porin"},{"id":"KW-0732","category":"Domain","name":"Signal"},{"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"id":"KW-1134","category":"Domain","name":"Transmembrane beta strand"},{"id":"KW-0813","category":"Biological process","name":"Transport"}],"references":[{"referenceNumber":1,"citation":{"id":"2356137","citationType":"journal article","authors":["Peterson E.M.","Markoff B.A.","de la Maza L.M."],"citationCrossReferences":[{"database":"PubMed","id":"2356137"},{"database":"DOI","id":"10.1093/nar/18.11.3414"}],"title":"The major outer membrane protein nucleotide sequence of Chlamydia trachomatis, serovar E.","publicationDate":"1990","journal":"Nucleic Acids Res.","firstPage":"3414","lastPage":"3414","volume":"18"},"referencePositions":["NUCLEOTIDE SEQUENCE [GENOMIC DNA]"],"referenceComments":[{"value":"BOUR / Serovar E","type":"STRAIN"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"X52557","properties":[{"key":"ProteinId","value":"CAA36791.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"PIR","id":"S10201","properties":[{"key":"EntryName","value":"MMCWTE"}]},{"database":"RefSeq","id":"WP_014541299.1","properties":[{"key":"NucleotideSequenceId","value":"NC_022108.1"}]},{"database":"AlphaFoldDB","id":"P17451","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"P17451","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"AAHMNAQ","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"GO","id":"GO:0009279","properties":[{"key":"GoTerm","value":"C:cell outer membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0015288","properties":[{"key":"GoTerm","value":"F:porin activity"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0005198","properties":[{"key":"GoTerm","value":"F:structural molecule activity"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"InterPro","id":"IPR000604","properties":[{"key":"EntryName","value":"Major_OMP_Chlamydia"}]},{"database":"Pfam","id":"PF01308","properties":[{"key":"EntryName","value":"Chlam_OMP"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR01334","properties":[{"key":"EntryName","value":"CHLAMIDIAOMP"}]}],"sequence":{"value":"MKKLLKSVLVFAALSSASSLQALPVGNPAEPSLMIDGILWEGFGGDPCDPCTTWCDAISMRMGYYGDFVFDRVLKTDVNKEFQMGDKPTSTTGNATAPTTLTARENPAYGRHMQDAEMFTNAACMALNIWDRFDVFCTLGASSGYLKGNSASFNLVGLFGDNENQSTVKTNSVPNMSLDQSVVELYTDTAFSWSVGARAALWECGCATLGASFQYAQSKPKVEELNVLCNAAEFTINKPKGYVGQEFPLALIAGTDAATGTKDASIDYHEWQASLALSYRLNMFTPYIGVKWSRASFDADTIRIAQPKSATAIFDTTTLNPTIAGAGDVKASAEGQLGDTMQIVSLQLNKMKSRKSCGIAVGTTIVDADKYAVTVETRLIDERAAHVNAQFRF","length":393,"molWeight":42424,"crc64":"AB2B82D16027B361","md5":"2A1D802C9E68065BC1371F27147CAD66"},"extraAttributes":{"countByCommentType":{"FUNCTION":2,"SUBUNIT":1,"SUBCELLULAR LOCATION":1,"DEVELOPMENTAL STAGE":1,"SIMILARITY":1},"countByFeatureType":{"Signal":1,"Chain":1},"uniParcId":"UPI0000130C9A"}},{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"P23732","uniProtkbId":"MOMPA_CHLTH","entryAudit":{"firstPublicDate":"1991-11-01","lastAnnotationUpdateDate":"2026-11-04","lastSequenceUpdateDate":"1991-11-01","entryVersion":77,"sequenceVersion":1},"annotationScore":3.0,"organism":{"scientificName":"Chlamydia trachomatis","taxonId":813,"lineage":["Bacteria","Pseudomonadati","Chlamydiota","Chlamydiia","Chlamydiales","Chlamydiaceae","Chlamydia/Chlamydophila group","Chlamydia"]},"proteinExistence":"2: Evidence at transcript level","proteinDescription":{"recommendedName":{"fullName":{"value":"Major outer membrane porin, serovar A"},"shortNames":[{"value":"MOMP"}]},"flag":"Precursor"},"genes":[{"geneName":{"value":"ompA"},"synonyms":[{"value":"omp1A"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250"}],"value":"In elementary bodies (EBs, the infectious stage, which is able to survive outside the host cell) provides the structural integrity of the outer envelope through disulfide cross-links with the small cysteine-rich protein and the large cysteine-rich periplasmic protein. It has been described in publications as the Sarkosyl-insoluble COMC (Chlamydia outer membrane complex), and serves as the functional equivalent of peptidoglycan (By similarity)"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250"}],"value":"Permits diffusion of specific solutes through the outer membrane"}],"commentType":"FUNCTION"},{"texts":[{"value":"Part of a disulfide cross-linked outer membrane complex (COMC) composed of the major outer membrane porin (MOMP), the small cysteine-rich protein (OmcA) and the large cysteine-rich periplasmic protein (OmcB)"}],"commentType":"SUBUNIT"},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000250"}],"value":"Cell outer membrane","id":"SL-0040"},"topology":{"evidences":[{"evidenceCode":"ECO:0000250"}],"value":"Multi-pass membrane protein","id":"SL-9909"}}]},{"texts":[{"value":"It is present but some of the disulfide bonds are reduced in reticulate bodies (RBs)"}],"commentType":"DEVELOPMENTAL STAGE"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Belongs to the chlamydial porin (CP) (TC 1.B.2) family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Signal","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":22,"modifier":"EXACT"}},"description":""},{"type":"Chain","location":{"start":{"value":23,"modifier":"EXACT"},"end":{"value":396,"modifier":"EXACT"}},"description":"Major outer membrane porin, serovar A","featureId":"PRO_0000020144"}],"keywords":[{"id":"KW-0998","category":"Cellular component","name":"Cell outer membrane"},{"id":"KW-0133","category":"Biological process","name":"Cell shape"},{"id":"KW-1015","category":"PTM","name":"Disulfide bond"},{"id":"KW-0406","category":"Biological process","name":"Ion transport"},{"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"id":"KW-0626","category":"Molecular function","name":"Porin"},{"id":"KW-0732","category":"Domain","name":"Signal"},{"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"id":"KW-1134","category":"Domain","name":"Transmembrane beta strand"},{"id":"KW-0813","category":"Biological process","name":"Transport"}],"references":[{"referenceNumber":1,"citation":{"id":"2235504","citationType":"journal article","authors":["Hayes L.J.","Clarke I.N."],"citationCrossReferences":[{"database":"PubMed","id":"2235504"},{"database":"DOI","id":"10.1093/nar/18.20.6136"}],"title":"Nucleotide sequence of the major outer membrane protein gene of Chlamydia trachomatis strain A/SA1/OT.","publicationDate":"1990","journal":"Nucleic Acids Res.","firstPage":"6136","lastPage":"6136","volume":"18"},"referencePositions":["NUCLEOTIDE SEQUENCE [GENOMIC DNA]"],"referenceComments":[{"value":"SA1/OT / Serovar A","type":"STRAIN"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"M58938","properties":[{"key":"ProteinId","value":"AAA23141.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"M33635","properties":[{"key":"ProteinId","value":"AAA92785.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"PIR","id":"S12799","properties":[{"key":"EntryName","value":"S12799"}]},{"database":"AlphaFoldDB","id":"P23732","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"P23732","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"AAHMNAQ","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"GO","id":"GO:0009279","properties":[{"key":"GoTerm","value":"C:cell outer membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0015288","properties":[{"key":"GoTerm","value":"F:porin activity"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0005198","properties":[{"key":"GoTerm","value":"F:structural molecule activity"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"InterPro","id":"IPR000604","properties":[{"key":"EntryName","value":"Major_OMP_Chlamydia"}]},{"database":"Pfam","id":"PF01308","properties":[{"key":"EntryName","value":"Chlam_OMP"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR01334","properties":[{"key":"EntryName","value":"CHLAMIDIAOMP"}]}],"sequence":{"value":"MKKLLKSVLVFAALSSASSLQALPVGNPAEPSLMIDGILWEGFGGDPCDPCTTWCDAISMRMGYYGDFVFDRVLKTDVNKEFQMGAAPTTRDVAGLEKDPVVNVARPNPAYGKHMQDAEMFTNAAYMALNIWDRFDVFCTLGATTGYLKGNSASFNLVGLFGTKTQSSGFDTANIVPNTALNQAVVELYTDTTFAWSVGARAALWECGCATLGASFQYAQSKPKVEELNVLCNASEFTINKPKGYVGAEFPLDITAGTEAATGTKDASIDYHEWQASLALSYRLNMFTPYIGVKWSRVSFDADTIRIAQPKLAKPVLDTTTLNPTIAGKGTVVSSAENELADTMQIVSLQLNKMKSRKSCGIAVGTTIVDADKYAVTVETRLIDERAAHVNAQFRF","length":396,"molWeight":42878,"crc64":"2F9D3B0CE2D08162","md5":"96C900D46D69490D1262EF8CE52BACAD"},"extraAttributes":{"countByCommentType":{"FUNCTION":2,"SUBUNIT":1,"SUBCELLULAR LOCATION":1,"DEVELOPMENTAL STAGE":1,"SIMILARITY":1},"countByFeatureType":{"Signal":1,"Chain":1},"uniParcId":"UPI0000130C96"}},{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"Q933I7","uniProtkbId":"OMCBI_CHLTH","entryAudit":{"firstPublicDate":"2006-09-05","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2001-12-01","entryVersion":65,"sequenceVersion":1},"annotationScore":3.0,"organism":{"scientificName":"Chlamydia trachomatis","taxonId":813,"lineage":["Bacteria","Pseudomonadati","Chlamydiota","Chlamydiia","Chlamydiales","Chlamydiaceae","Chlamydia/Chlamydophila group","Chlamydia"]},"proteinExistence":"3: Inferred from homology","proteinDescription":{"recommendedName":{"fullName":{"value":"Large cysteine-rich periplasmic protein OmcB, serovars I/J"},"shortNames":[{"value":"Large-CRP"}]},"alternativeNames":[{"fullName":{"value":"60 kDa CRP"}},{"fullName":{"value":"60 kDa outer membrane protein"}},{"fullName":{"value":"Cysteine-rich outer membrane protein"}}],"flag":"Precursor"},"genes":[{"geneName":{"value":"omcB"},"synonyms":[{"value":"ompA"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250"}],"value":"In elementary bodies (EBs, the infectious stage, which is able to survive outside the host cell) provides the structural integrity of the outer envelope through disulfide cross-links with the small cysteine-rich protein and the major outer membrane porin. It has been described in publications as the Sarkosyl-insoluble COMC (Chlamydia outer membrane complex), and serves as the functional equivalent of peptidoglycan. It is present but the disulfide bonds are reduced in reticulate bodies (RBs) (By similarity)"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250"}],"value":"Part of a disulfide cross-linked outer membrane complex (COMC) composed of the major outer membrane porin (MOMP), the small cysteine-rich protein (OmcA) and the large cysteine-rich periplasmic protein (OmcB)"}],"commentType":"SUBUNIT"},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Periplasm","id":"SL-0200"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Was thought to be an outer membrane protein as it is part of a disulfide cross-linked complex that is insoluble in the detergent Sarkosyl; however based on experiments in C.psittaci it is likely to be periplasmic"}],"commentType":"CAUTION"}],"features":[{"type":"Signal","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":22,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Propeptide","location":{"start":{"value":23,"modifier":"EXACT"},"end":{"value":40,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000255"}],"featureId":"PRO_0000248875"},{"type":"Chain","location":{"start":{"value":41,"modifier":"EXACT"},"end":{"value":547,"modifier":"EXACT"}},"description":"Large cysteine-rich periplasmic protein OmcB, serovars I/J","featureId":"PRO_0000248876"},{"type":"Region","location":{"start":{"value":45,"modifier":"EXACT"},"end":{"value":84,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":52,"modifier":"EXACT"},"end":{"value":61,"modifier":"EXACT"}},"description":"Basic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":62,"modifier":"EXACT"},"end":{"value":79,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]}],"keywords":[{"id":"KW-0133","category":"Biological process","name":"Cell shape"},{"id":"KW-1015","category":"PTM","name":"Disulfide bond"},{"id":"KW-0574","category":"Cellular component","name":"Periplasm"},{"id":"KW-0732","category":"Domain","name":"Signal"}],"references":[{"referenceNumber":1,"citation":{"id":"11567000","citationType":"journal article","authors":["Millman K.L.","Tavare S.","Dean D."],"citationCrossReferences":[{"database":"PubMed","id":"11567000"},{"database":"DOI","id":"10.1128/jb.183.20.5997-6008.2001"}],"title":"Recombination in the ompA gene but not the omcB gene of Chlamydia contributes to serovar-specific differences in tissue tropism, immune surveillance, and persistence of the organism.","publicationDate":"2001","journal":"J. Bacteriol.","firstPage":"5997","lastPage":"6008","volume":"183"},"referencePositions":["NUCLEOTIDE SEQUENCE [GENOMIC DNA]"],"referenceComments":[{"value":"I/UW-12","type":"STRAIN"},{"value":"J/UW-36","type":"STRAIN"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AF304330","properties":[{"key":"ProteinId","value":"AAL14100.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AF304329","properties":[{"key":"ProteinId","value":"AAL14099.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"AlphaFoldDB","id":"Q933I7","properties":[{"key":"Description","value":"-"}]},{"database":"GO","id":"GO:0042597","properties":[{"key":"GoTerm","value":"C:periplasmic space"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0005201","properties":[{"key":"GoTerm","value":"F:extracellular matrix structural constituent"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"Gene3D","id":"2.60.40.10","properties":[{"key":"EntryName","value":"Immunoglobulins"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR003506","properties":[{"key":"EntryName","value":"Chlam_OMP6"}]},{"database":"InterPro","id":"IPR051172","properties":[{"key":"EntryName","value":"Chlamydia_OmcB"}]},{"database":"InterPro","id":"IPR047589","properties":[{"key":"EntryName","value":"DUF11_rpt"}]},{"database":"InterPro","id":"IPR013783","properties":[{"key":"EntryName","value":"Ig-like_fold"}]},{"database":"InterPro","id":"IPR001434","properties":[{"key":"EntryName","value":"OmcB-like_DUF11"}]},{"database":"NCBIfam","id":"TIGR01451","properties":[{"key":"EntryName","value":"B_ant_repeat"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR34819","properties":[{"key":"EntryName","value":"LARGE CYSTEINE-RICH PERIPLASMIC PROTEIN OMCB"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR34819:SF4","properties":[{"key":"EntryName","value":"LARGE CYSTEINE-RICH PERIPLASMIC PROTEIN OMCB"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF03504","properties":[{"key":"EntryName","value":"Chlam_OMP6"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF01345","properties":[{"key":"EntryName","value":"CLIPPER"},{"key":"MatchStatus","value":"3"}]},{"database":"PRINTS","id":"PR01336","properties":[{"key":"EntryName","value":"CHLAMIDIAOM6"}]}],"sequence":{"value":"MNKLIRRAVTIFAVTSVASLFASGVLETSMAESLSTNVISLADTKAKDNTSHKSKKARKNHSKETPVDRKEVAPVHESKATGPKQDSCFGRMYTVKVNDDRNVEITQAVPEYATVGSPYPIEITATGKRDCVDVIITQQLPCEAEFVRSDPATTPTADGKLVWKIDRLGQGEKSKITVWVKPLKEGCCFTAATVCACPEIRSVTKCGQPAICVKQEGPENACLRCPVVYKINVVNQGTATARNVVVENPVPDGYAHSSGQRVLTFTLGDMQPGEHRTITVEFCPLKRGCATNIATVSYCGGHKNTASVTTVINEPCVQVSIAGADWSYVCKPVEYVISVSNPGDLVLRDVVVEDTLSPGVTVLEAAGAQISCNKVVWTVKELNPGESLQYKVLVRAQTPGQFTNNVVVKSCSDCGTCTSCAEATTYWKGVAATHMCVVDTCDPVCVGENTVYRICVTNRGSAEDTNVSLMLKFSKELQPVSFSGPTKGTITGNTVVFDSLPRLGSKETVEFSVTLKAVSAGDARGEAILSSDTLTVPVSDTENTHIY","length":547,"molWeight":58627,"crc64":"817BA3000FEA6A71","md5":"C681A3F13F78C9CE6AB93D51951B7172"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"SUBUNIT":1,"SUBCELLULAR LOCATION":1,"CAUTION":1},"countByFeatureType":{"Signal":1,"Propeptide":1,"Chain":1,"Region":1,"Compositional bias":2},"uniParcId":"UPI00000B1E46"}},{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"P16155","uniProtkbId":"MOMPF_CHLTH","entryAudit":{"firstPublicDate":"1990-04-01","lastAnnotationUpdateDate":"2026-11-04","lastSequenceUpdateDate":"1990-04-01","entryVersion":92,"sequenceVersion":1},"annotationScore":3.0,"organism":{"scientificName":"Chlamydia trachomatis","taxonId":813,"lineage":["Bacteria","Pseudomonadati","Chlamydiota","Chlamydiia","Chlamydiales","Chlamydiaceae","Chlamydia/Chlamydophila group","Chlamydia"]},"proteinExistence":"2: Evidence at transcript level","proteinDescription":{"recommendedName":{"fullName":{"value":"Major outer membrane porin, serovar F"},"shortNames":[{"value":"MOMP"}]},"flag":"Precursor"},"genes":[{"geneName":{"value":"ompA"},"synonyms":[{"value":"omp1F"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250"}],"value":"In elementary bodies (EBs, the infectious stage, which is able to survive outside the host cell) provides the structural integrity of the outer envelope through disulfide cross-links with the small cysteine-rich protein and the large cysteine-rich periplasmic protein. It has been described in publications as the Sarkosyl-insoluble COMC (Chlamydia outer membrane complex), and serves as the functional equivalent of peptidoglycan (By similarity)"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250"}],"value":"Permits diffusion of specific solutes through the outer membrane"}],"commentType":"FUNCTION"},{"texts":[{"value":"Part of a disulfide cross-linked outer membrane complex (COMC) composed of the major outer membrane porin (MOMP), the small cysteine-rich protein (OmcA) and the large cysteine-rich periplasmic protein (OmcB)"}],"commentType":"SUBUNIT"},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000250"}],"value":"Cell outer membrane","id":"SL-0040"},"topology":{"evidences":[{"evidenceCode":"ECO:0000250"}],"value":"Multi-pass membrane protein","id":"SL-9909"}}]},{"texts":[{"value":"It is present but some of the disulfide bonds are reduced in reticulate bodies (RBs)"}],"commentType":"DEVELOPMENTAL STAGE"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Belongs to the chlamydial porin (CP) (TC 1.B.2) family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Signal","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":22,"modifier":"EXACT"}},"description":""},{"type":"Chain","location":{"start":{"value":23,"modifier":"EXACT"},"end":{"value":395,"modifier":"EXACT"}},"description":"Major outer membrane porin, serovar F","featureId":"PRO_0000020149"}],"keywords":[{"id":"KW-0998","category":"Cellular component","name":"Cell outer membrane"},{"id":"KW-0133","category":"Biological process","name":"Cell shape"},{"id":"KW-1015","category":"PTM","name":"Disulfide bond"},{"id":"KW-0406","category":"Biological process","name":"Ion transport"},{"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"id":"KW-0626","category":"Molecular function","name":"Porin"},{"id":"KW-0732","category":"Domain","name":"Signal"},{"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"id":"KW-1134","category":"Domain","name":"Transmembrane beta strand"},{"id":"KW-0813","category":"Biological process","name":"Transport"}],"references":[{"referenceNumber":1,"citation":{"id":"2315025","citationType":"journal article","authors":["Zhang Y.-X.","Morrison S.G.","Caldwell H.D."],"citationCrossReferences":[{"database":"PubMed","id":"2315025"},{"database":"DOI","id":"10.1093/nar/18.4.1061"}],"title":"The nucleotide sequence of major outer membrane protein gene of Chlamydia trachomatis serovar F.","publicationDate":"1990","journal":"Nucleic Acids Res.","firstPage":"1061","lastPage":"1061","volume":"18"},"referencePositions":["NUCLEOTIDE SEQUENCE [GENOMIC DNA]"],"referenceComments":[{"value":"IC-CAL3 / Serovar F","type":"STRAIN"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"X52080","properties":[{"key":"ProteinId","value":"CAA36299.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"PIR","id":"S08463","properties":[{"key":"EntryName","value":"MMCWTF"}]},{"database":"RefSeq","id":"WP_009872844.1","properties":[{"key":"NucleotideSequenceId","value":"NC_022106.1"}]},{"database":"AlphaFoldDB","id":"P16155","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"P16155","properties":[{"key":"Description","value":"-"}]},{"database":"eggNOG","id":"ENOG502ZVFZ","properties":[{"key":"ToxonomicScope","value":"Bacteria"}]},{"database":"OMA","id":"AAHMNAQ","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"GO","id":"GO:0009279","properties":[{"key":"GoTerm","value":"C:cell outer membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0015288","properties":[{"key":"GoTerm","value":"F:porin activity"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0005198","properties":[{"key":"GoTerm","value":"F:structural molecule activity"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"InterPro","id":"IPR000604","properties":[{"key":"EntryName","value":"Major_OMP_Chlamydia"}]},{"database":"Pfam","id":"PF01308","properties":[{"key":"EntryName","value":"Chlam_OMP"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR01334","properties":[{"key":"EntryName","value":"CHLAMIDIAOMP"}]}],"sequence":{"value":"MKKLLKSVLVFAALSSASSLQALPVGNPAEPSLMIDGILWEGFGGDPCDPCTTWCDAISMRMGYYGDFVFDRVLKTDVNKEFEMGEALAGASGNTTSTLSKLVERTNPAYGKHMQDAEMFTNAACMTLNIWDRFDVFCTLGATSGYLKGNSASFNLVGLFGDGVNATKPAADSIPNVQLNQSVVELYTDTTFAWSVGARAALWECGCATLGASFQYAQSKPKIEELNVLCNAAEFTINKPKGYVGKEFPLDLTAGTDAATGTKDASIDYHEWQASLSLSYRLNMFTPYIGVKWSRASFDSDTIRIAQPRLVTPVVDITTLNPTIAGCGSVAGANTEGQISDTMQIVSLQLNKMKSRKSCGIAVGTTIVDADKYAVTVETRLIDERAAHVNAQFRF","length":395,"molWeight":42586,"crc64":"7F90FFDEEC264ACF","md5":"EBDD69133D8CEF347DF5798FCA73685D"},"extraAttributes":{"countByCommentType":{"FUNCTION":2,"SUBUNIT":1,"SUBCELLULAR LOCATION":1,"DEVELOPMENTAL STAGE":1,"SIMILARITY":1},"countByFeatureType":{"Signal":1,"Chain":1},"uniParcId":"UPI0000130C9B"}},{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"P23114","uniProtkbId":"MOMPN_CHLTH","entryAudit":{"firstPublicDate":"1991-11-01","lastAnnotationUpdateDate":"2026-11-04","lastSequenceUpdateDate":"1991-11-01","entryVersion":78,"sequenceVersion":1},"annotationScore":3.0,"organism":{"scientificName":"Chlamydia trachomatis","taxonId":813,"lineage":["Bacteria","Pseudomonadati","Chlamydiota","Chlamydiia","Chlamydiales","Chlamydiaceae","Chlamydia/Chlamydophila group","Chlamydia"]},"proteinExistence":"2: Evidence at transcript level","proteinDescription":{"recommendedName":{"fullName":{"value":"Major outer membrane porin, serovar L3"},"shortNames":[{"value":"MOMP"}]},"flag":"Precursor"},"genes":[{"geneName":{"value":"ompA"},"synonyms":[{"value":"omp1L3"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250"}],"value":"In elementary bodies (EBs, the infectious stage, which is able to survive outside the host cell) provides the structural integrity of the outer envelope through disulfide cross-links with the small cysteine-rich protein and the large cysteine-rich periplasmic protein. It has been described in publications as the Sarkosyl-insoluble COMC (Chlamydia outer membrane complex), and serves as the functional equivalent of peptidoglycan (By similarity)"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250"}],"value":"Permits diffusion of specific solutes through the outer membrane"}],"commentType":"FUNCTION"},{"texts":[{"value":"Part of a disulfide cross-linked outer membrane complex (COMC) composed of the major outer membrane porin (MOMP), the small cysteine-rich protein (OmcA) and the large cysteine-rich periplasmic protein (OmcB)"}],"commentType":"SUBUNIT"},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000250"}],"value":"Cell outer membrane","id":"SL-0040"},"topology":{"evidences":[{"evidenceCode":"ECO:0000250"}],"value":"Multi-pass membrane protein","id":"SL-9909"}}]},{"texts":[{"value":"It is present but some of the disulfide bonds are reduced in reticulate bodies (RBs)"}],"commentType":"DEVELOPMENTAL STAGE"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Belongs to the chlamydial porin (CP) (TC 1.B.2) family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Signal","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":22,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000250"}]},{"type":"Chain","location":{"start":{"value":23,"modifier":"EXACT"},"end":{"value":397,"modifier":"EXACT"}},"description":"Major outer membrane porin, serovar L3","featureId":"PRO_0000020153"}],"keywords":[{"id":"KW-0998","category":"Cellular component","name":"Cell outer membrane"},{"id":"KW-0133","category":"Biological process","name":"Cell shape"},{"id":"KW-1015","category":"PTM","name":"Disulfide bond"},{"id":"KW-0406","category":"Biological process","name":"Ion transport"},{"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"id":"KW-0626","category":"Molecular function","name":"Porin"},{"id":"KW-0732","category":"Domain","name":"Signal"},{"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"id":"KW-1134","category":"Domain","name":"Transmembrane beta strand"},{"id":"KW-0813","category":"Biological process","name":"Transport"}],"references":[{"referenceNumber":1,"citation":{"id":"2060793","citationType":"journal article","authors":["Fielder T.J.","Peterson E.M.","de la Maza L.M."],"citationCrossReferences":[{"database":"PubMed","id":"2060793"},{"database":"DOI","id":"10.1016/0378-1119(91)90240-c"}],"title":"Nucleotide sequence of DNA encoding the major outer membrane protein of Chlamydia trachomatis serovar L3.","publicationDate":"1991","journal":"Gene","firstPage":"159","lastPage":"160","volume":"101"},"referencePositions":["NUCLEOTIDE SEQUENCE [GENOMIC DNA]"],"referenceComments":[{"value":"L3/404","type":"STRAIN"}]},{"referenceNumber":2,"citation":{"id":"2139622","citationType":"journal article","authors":["Kaul R.","Duncan M.J.","Guest J.","Wenman W.M."],"citationCrossReferences":[{"database":"PubMed","id":"2139622"},{"database":"DOI","id":"10.1016/0378-1119(90)90499-h"}],"title":"Expression of the Chlamydia trachomatis major outer membrane protein-encoding gene in Escherichia coli: role of the 3' end in mRNA stability.","publicationDate":"1990","journal":"Gene","firstPage":"97","lastPage":"103","volume":"87"},"referencePositions":["NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 81-136"]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"X55700","properties":[{"key":"ProteinId","value":"CAA39226.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"PIR","id":"JE0413","properties":[{"key":"EntryName","value":"JE0413"}]},{"database":"RefSeq","id":"WP_015506631.1","properties":[{"key":"NucleotideSequenceId","value":"NZ_CP166111.1"}]},{"database":"AlphaFoldDB","id":"P23114","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"P23114","properties":[{"key":"Description","value":"-"}]},{"database":"GO","id":"GO:0009279","properties":[{"key":"GoTerm","value":"C:cell outer membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0015288","properties":[{"key":"GoTerm","value":"F:porin activity"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0005198","properties":[{"key":"GoTerm","value":"F:structural molecule activity"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"InterPro","id":"IPR000604","properties":[{"key":"EntryName","value":"Major_OMP_Chlamydia"}]},{"database":"Pfam","id":"PF01308","properties":[{"key":"EntryName","value":"Chlam_OMP"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR01334","properties":[{"key":"EntryName","value":"CHLAMIDIAOMP"}]}],"sequence":{"value":"MKKLLKSVLVFAALSSASSLQALPVGNPAEPSLMIDGILWEGFGGDPCDPCTTWCDAISMRVGYYGDFVFDRVLKTDVNKEFQMGAEPTTSDTAGLSNDPTTNVARPNPAYGKHMQDAEMFTNAAYMALNIWDRFDVFCTLGATTGYLKGNSASFNLVGLFGTKTQSTNFNTAKLVPNTALNQAVVELYTDTTFAWSVGARAALWECGCATLGASFQYAQSKPKVEELNVLCDASEFTINKPKGYVGAEFPLDITAGTEAATGTKDASIDYHEWQASLALSYRLNMFTPYIGVKWSRVSFDADTIRIAQPKLAEAVLDVTTLNPTIAGKGSVVASGSENELADTMQIVSLQLNKMKSRKSCGIAVGTTIVDADKYAVTVETRLIDERAAHVNAQFRF","length":397,"molWeight":42886,"crc64":"F1DDCF09535C2595","md5":"2CE46D064039D3F57E10E488B79A6C30"},"extraAttributes":{"countByCommentType":{"FUNCTION":2,"SUBUNIT":1,"SUBCELLULAR LOCATION":1,"DEVELOPMENTAL STAGE":1,"SIMILARITY":1},"countByFeatureType":{"Signal":1,"Chain":1},"uniParcId":"UPI0000130CA0"}},{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"P23603","uniProtkbId":"OMCBE_CHLTH","entryAudit":{"firstPublicDate":"1991-11-01","lastAnnotationUpdateDate":"2026-11-04","lastSequenceUpdateDate":"1997-11-01","entryVersion":101,"sequenceVersion":2},"annotationScore":3.0,"organism":{"scientificName":"Chlamydia trachomatis","taxonId":813,"lineage":["Bacteria","Pseudomonadati","Chlamydiota","Chlamydiia","Chlamydiales","Chlamydiaceae","Chlamydia/Chlamydophila group","Chlamydia"]},"proteinExistence":"2: Evidence at transcript level","proteinDescription":{"recommendedName":{"fullName":{"value":"Large cysteine-rich periplasmic protein OmcB, serovar E"},"shortNames":[{"value":"Large-CRP"}]},"alternativeNames":[{"fullName":{"value":"60 kDa CRP"}},{"fullName":{"value":"60 kDa outer membrane protein"}},{"fullName":{"value":"Cysteine-rich outer membrane protein"}}],"flag":"Precursor"},"genes":[{"geneName":{"value":"omcB"},"synonyms":[{"value":"omp2"},{"value":"omp2B"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250"}],"value":"In elementary bodies (EBs, the infectious stage, which is able to survive outside the host cell) provides the structural integrity of the outer envelope through disulfide cross-links with the small cysteine-rich protein and the major outer membrane protein. It has been described in publications as the Sarkosyl-insoluble COMC (Chlamydia outer membrane complex), and serves as the functional equivalent of peptidoglycan (By similarity)"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250"}],"value":"Part of a disulfide cross-linked outer membrane complex (COMC) composed of the major outer membrane porin (MOMP), the small cysteine-rich protein (OmcA) and the large cysteine-rich periplasmic protein (OmcB)"}],"commentType":"SUBUNIT"},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Periplasm","id":"SL-0200"}}]},{"texts":[{"value":"It is present but the disulfide bonds are reduced in the intracellular reticulate bodies (RBs)"}],"commentType":"DEVELOPMENTAL STAGE"},{"texts":[{"value":"The sequence shown is that of strain DK 20"}],"commentType":"MISCELLANEOUS"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Was thought to be an outer membrane protein as it is part of a disulfide cross-linked complex that is insoluble in the detergent Sarkosyl; however based on experiments in C.psittaci it is likely to be periplasmic"}],"commentType":"CAUTION"}],"features":[{"type":"Signal","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":22,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Propeptide","location":{"start":{"value":23,"modifier":"EXACT"},"end":{"value":40,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000255"}],"featureId":"PRO_0000020172"},{"type":"Chain","location":{"start":{"value":41,"modifier":"EXACT"},"end":{"value":547,"modifier":"EXACT"}},"description":"Large cysteine-rich periplasmic protein OmcB, serovar E","featureId":"PRO_0000020173"},{"type":"Region","location":{"start":{"value":46,"modifier":"EXACT"},"end":{"value":83,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":52,"modifier":"EXACT"},"end":{"value":61,"modifier":"EXACT"}},"description":"Basic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":62,"modifier":"EXACT"},"end":{"value":79,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Natural variant","location":{"start":{"value":33,"modifier":"EXACT"},"end":{"value":34,"modifier":"EXACT"}},"description":"in strain: DK20","featureId":"","alternativeSequence":{"originalSequence":"SL","alternativeSequences":["FT"]}},{"type":"Natural variant","location":{"start":{"value":121,"modifier":"EXACT"},"end":{"value":121,"modifier":"EXACT"}},"description":"in strain: DK20","featureId":"","alternativeSequence":{"originalSequence":"I","alternativeSequences":["L"]}},{"type":"Natural variant","location":{"start":{"value":132,"modifier":"EXACT"},"end":{"value":132,"modifier":"EXACT"}},"description":"in strain: DK20","featureId":"","alternativeSequence":{"originalSequence":"V","alternativeSequences":["A"]}},{"type":"Natural variant","location":{"start":{"value":458,"modifier":"EXACT"},"end":{"value":458,"modifier":"EXACT"}},"description":"in strain: DK20","featureId":"","alternativeSequence":{"originalSequence":"N","alternativeSequences":["S"]}}],"keywords":[{"id":"KW-0133","category":"Biological process","name":"Cell shape"},{"id":"KW-1015","category":"PTM","name":"Disulfide bond"},{"id":"KW-0574","category":"Cellular component","name":"Periplasm"},{"id":"KW-0732","category":"Domain","name":"Signal"}],"references":[{"referenceNumber":1,"citation":{"id":"2251143","citationType":"journal article","authors":["Coles A.M.","Allan I.","Pearce J.H."],"citationCrossReferences":[{"database":"PubMed","id":"2251143"},{"database":"DOI","id":"10.1093/nar/18.22.6713"}],"title":"The nucleotide and derived amino acid sequence of the omp2 gene of Chlamydia trachomatis serovar E.","publicationDate":"1990","journal":"Nucleic Acids Res.","firstPage":"6713","lastPage":"6713","volume":"18"},"referencePositions":["NUCLEOTIDE SEQUENCE [GENOMIC DNA]"],"referenceComments":[{"value":"E/DK-20","type":"STRAIN"}]},{"referenceNumber":2,"citation":{"id":"1997423","citationType":"journal article","authors":["de la Maza L.M.","Fiedler T.J.","Carlson E.J.","Markoff B.A.","Peterson E.M."],"citationCrossReferences":[{"database":"PubMed","id":"1997423"},{"database":"DOI","id":"10.1128/iai.59.3.1196-1201.1991"}],"title":"Sequence diversity of the 60-kilodalton protein and of a putative 15-kilodalton protein between the trachoma and lymphogranuloma venereum biovars of Chlamydia trachomatis.","publicationDate":"1991","journal":"Infect. Immun.","firstPage":"1196","lastPage":"1201","volume":"59"},"referencePositions":["NUCLEOTIDE SEQUENCE [GENOMIC DNA]"],"referenceComments":[{"value":"BOUR / Serovar E","type":"STRAIN"}]},{"referenceNumber":3,"citation":{"id":"CI-FBSRQETPOE0DQ","citationType":"submission","authors":["Zhang Y.-X.","Caldwell H.D."],"title":"The nucleotide sequences of 10 and 60 kDa cysteine-rich outer membrane protein genes of Chlamydia trachomatis serovar F.","publicationDate":"FEB-1992","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [GENOMIC DNA]"]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"X55903","properties":[{"key":"ProteinId","value":"CAA39396.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"X54389","properties":[{"key":"ProteinId","value":"CAA38259.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"M85196","properties":[{"key":"ProteinId","value":"AAA23154.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"PIR","id":"B43584","properties":[{"key":"EntryName","value":"B43584"}]},{"database":"AlphaFoldDB","id":"P23603","properties":[{"key":"Description","value":"-"}]},{"database":"eggNOG","id":"COG1361","properties":[{"key":"ToxonomicScope","value":"Bacteria"}]},{"database":"OMA","id":"AATHMCV","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"GO","id":"GO:0042597","properties":[{"key":"GoTerm","value":"C:periplasmic space"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0005201","properties":[{"key":"GoTerm","value":"F:extracellular matrix structural constituent"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"Gene3D","id":"2.60.40.10","properties":[{"key":"EntryName","value":"Immunoglobulins"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR003506","properties":[{"key":"EntryName","value":"Chlam_OMP6"}]},{"database":"InterPro","id":"IPR051172","properties":[{"key":"EntryName","value":"Chlamydia_OmcB"}]},{"database":"InterPro","id":"IPR047589","properties":[{"key":"EntryName","value":"DUF11_rpt"}]},{"database":"InterPro","id":"IPR013783","properties":[{"key":"EntryName","value":"Ig-like_fold"}]},{"database":"InterPro","id":"IPR001434","properties":[{"key":"EntryName","value":"OmcB-like_DUF11"}]},{"database":"NCBIfam","id":"TIGR01451","properties":[{"key":"EntryName","value":"B_ant_repeat"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR34819","properties":[{"key":"EntryName","value":"LARGE CYSTEINE-RICH PERIPLASMIC PROTEIN OMCB"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR34819:SF4","properties":[{"key":"EntryName","value":"LARGE CYSTEINE-RICH PERIPLASMIC PROTEIN OMCB"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF03504","properties":[{"key":"EntryName","value":"Chlam_OMP6"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF01345","properties":[{"key":"EntryName","value":"CLIPPER"},{"key":"MatchStatus","value":"3"}]},{"database":"PRINTS","id":"PR01336","properties":[{"key":"EntryName","value":"CHLAMIDIAOM6"}]}],"sequence":{"value":"MNKLIRRAVTIFAVTSVASLFASGVLETSMAESLSTNVISLADTKAKDNTSHKSKKARKNHSKETLVDRKEVAPVHESKATGPKQDSCFGRMYTVKVNDDRNVEITQAVPEYATVGSPYPIEITATGKRDCVDVIITQQLPCEAEFVRSDPATTPTADGKLVWKIDRLGQGEKSKITVWVKPLKEGCCFTAATVCACPEIRSVTKCGQPAICVKQEGPENACLRCPVVYKINVVNQGTAIARNVVVENPVPDGYAHSSGQRVLTFTLGDMQPGEHRTITVEFCPLKRGRATNIATVSYCGGHKNTASVTTVINEPCVQVSIAGADWSYVCKPVEYVISVSNPGDLVLRDVVVEDTLSPGVTVLEAAGAQISCNKVVWTVKELNPGESLQYKVLVRAQTPGQFTNNVVVKSCSDCGTCTSCAEATTYWKGVAATHMCVVDTCDPVCVGENTVYRICVTNRGSAEDTNVSLMLKFSKELQPVSFSGPTKGTITGNTVVFDSLPRLGSKETVEFSVTLKAVSAGDARGEAILSSDTLTVPVSDTENTHIY","length":547,"molWeight":58708,"crc64":"052066084F4E20AB","md5":"739352CC77C374F35ED88A3C1C2B0BF3"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"SUBUNIT":1,"SUBCELLULAR LOCATION":1,"DEVELOPMENTAL STAGE":1,"MISCELLANEOUS":1,"CAUTION":1},"countByFeatureType":{"Signal":1,"Propeptide":1,"Chain":1,"Region":1,"Compositional bias":2,"Natural variant":4},"uniParcId":"UPI0000130CC7"}},{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"P26758","uniProtkbId":"OMCBC_CHLTH","entryAudit":{"firstPublicDate":"1992-08-01","lastAnnotationUpdateDate":"2026-11-04","lastSequenceUpdateDate":"1992-08-01","entryVersion":91,"sequenceVersion":1},"annotationScore":3.0,"organism":{"scientificName":"Chlamydia trachomatis","taxonId":813,"lineage":["Bacteria","Pseudomonadati","Chlamydiota","Chlamydiia","Chlamydiales","Chlamydiaceae","Chlamydia/Chlamydophila group","Chlamydia"]},"proteinExistence":"2: Evidence at transcript level","proteinDescription":{"recommendedName":{"fullName":{"value":"Large cysteine-rich periplasmic protein OmcB, serovar C"},"shortNames":[{"value":"Large-CRP"}]},"alternativeNames":[{"fullName":{"value":"60 kDa CRP"}},{"fullName":{"value":"60 kDa outer membrane protein"}},{"fullName":{"value":"Cysteine-rich outer membrane protein"}}],"flag":"Precursor"},"genes":[{"geneName":{"value":"omcB"},"synonyms":[{"value":"omp2"},{"value":"omp2B"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250"}],"value":"In elementary bodies (EBs, the infectious stage, which is able to survive outside the host cell) provides the structural integrity of the outer envelope through disulfide cross-links with the small cysteine-rich protein and the major outer membrane porin. It has been described in publications as the Sarkosyl-insoluble COMC (Chlamydia outer membrane complex), and serves as the functional equivalent of peptidoglycan (By similarity)"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250"}],"value":"Part of a disulfide cross-linked outer membrane complex (COMC) composed of the major outer membrane porin (MOMP), the small cysteine-rich protein (OmcA) and the large cysteine-rich periplasmic protein (OmcB)"}],"commentType":"SUBUNIT"},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Periplasm","id":"SL-0200"}}]},{"texts":[{"value":"It is present but the disulfide bonds are reduced in the intracellular reticulate bodies (RBs)"}],"commentType":"DEVELOPMENTAL STAGE"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Was thought to be an outer membrane protein as it is part of a disulfide cross-linked complex that is insoluble in the detergent Sarkosyl; however based on experiments in C.psittaci it is likely to be periplasmic"}],"commentType":"CAUTION"}],"features":[{"type":"Signal","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":22,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Propeptide","location":{"start":{"value":23,"modifier":"EXACT"},"end":{"value":40,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000255"}],"featureId":"PRO_0000020168"},{"type":"Chain","location":{"start":{"value":41,"modifier":"EXACT"},"end":{"value":547,"modifier":"EXACT"}},"description":"Large cysteine-rich periplasmic protein OmcB, serovar C","featureId":"PRO_0000020169"},{"type":"Region","location":{"start":{"value":45,"modifier":"EXACT"},"end":{"value":84,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":52,"modifier":"EXACT"},"end":{"value":61,"modifier":"EXACT"}},"description":"Basic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":62,"modifier":"EXACT"},"end":{"value":79,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]}],"keywords":[{"id":"KW-0133","category":"Biological process","name":"Cell shape"},{"id":"KW-1015","category":"PTM","name":"Disulfide bond"},{"id":"KW-0574","category":"Cellular component","name":"Periplasm"},{"id":"KW-0732","category":"Domain","name":"Signal"}],"references":[{"referenceNumber":1,"citation":{"id":"1997423","citationType":"journal article","authors":["de la Maza L.M.","Fiedler T.J.","Carlson E.J.","Markoff B.A.","Peterson E.M."],"citationCrossReferences":[{"database":"PubMed","id":"1997423"},{"database":"DOI","id":"10.1128/iai.59.3.1196-1201.1991"}],"title":"Sequence diversity of the 60-kilodalton protein and of a putative 15-kilodalton protein between the trachoma and lymphogranuloma venereum biovars of Chlamydia trachomatis.","publicationDate":"1991","journal":"Infect. Immun.","firstPage":"1196","lastPage":"1201","volume":"59"},"referencePositions":["NUCLEOTIDE SEQUENCE [GENOMIC DNA]"],"referenceComments":[{"value":"C/TW-3","type":"STRAIN"}]},{"referenceNumber":2,"citation":{"id":"CI-FBSRQETPOE0DQ","citationType":"submission","authors":["Zhang Y.-X.","Caldwell H.D."],"title":"The nucleotide sequences of 10 and 60 kDa cysteine-rich outer membrane protein genes of Chlamydia trachomatis serovar F.","publicationDate":"FEB-1992","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [GENOMIC DNA]"],"referenceComments":[{"value":"C/TW-3","type":"STRAIN"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"X54388","properties":[{"key":"ProteinId","value":"CAA38257.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"M85197","properties":[{"key":"ProteinId","value":"AAA23159.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"PIR","id":"D71515","properties":[{"key":"EntryName","value":"D71515"}]},{"database":"AlphaFoldDB","id":"P26758","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"AATHMCV","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"GO","id":"GO:0042597","properties":[{"key":"GoTerm","value":"C:periplasmic space"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0005201","properties":[{"key":"GoTerm","value":"F:extracellular matrix structural constituent"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"Gene3D","id":"2.60.40.10","properties":[{"key":"EntryName","value":"Immunoglobulins"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR003506","properties":[{"key":"EntryName","value":"Chlam_OMP6"}]},{"database":"InterPro","id":"IPR051172","properties":[{"key":"EntryName","value":"Chlamydia_OmcB"}]},{"database":"InterPro","id":"IPR047589","properties":[{"key":"EntryName","value":"DUF11_rpt"}]},{"database":"InterPro","id":"IPR013783","properties":[{"key":"EntryName","value":"Ig-like_fold"}]},{"database":"InterPro","id":"IPR001434","properties":[{"key":"EntryName","value":"OmcB-like_DUF11"}]},{"database":"NCBIfam","id":"TIGR01451","properties":[{"key":"EntryName","value":"B_ant_repeat"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR34819","properties":[{"key":"EntryName","value":"LARGE CYSTEINE-RICH PERIPLASMIC PROTEIN OMCB"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR34819:SF4","properties":[{"key":"EntryName","value":"LARGE CYSTEINE-RICH PERIPLASMIC PROTEIN OMCB"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF03504","properties":[{"key":"EntryName","value":"Chlam_OMP6"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF01345","properties":[{"key":"EntryName","value":"CLIPPER"},{"key":"MatchStatus","value":"3"}]},{"database":"PRINTS","id":"PR01336","properties":[{"key":"EntryName","value":"CHLAMIDIAOM6"}]}],"sequence":{"value":"MNKLIRRAVTIFAVTSVASLFASGVLETSMAESLSTNVISLADTKAKDNTSHKSKKARKNHSKETPVDRKEVAPVHESKATGPKQDSCFGRMYTVKVNDDRNVEITQAVPEYATVGSPYPIEITATGKRDCVDVIITQQLPCEAEFVRSDPATTPTADGKLVWKIDRLGQGEKSKITVWVKPLKEGCCFTAATVCACPEIRSVTKCGQPAICVKQEGPENACLRCPVVYKINVVNQGTATARNVVVENPVPDGYAHSSGQRVLTFTLGDMQPGEHRTITVEFCPLKRGRATNIATVSYCGGHKNTASVTTVINEPCVQVSIAGADWSYVCKPVEYVISVSNPGDLVLRDVVVEDTLSPGVTVLEAAGAQISCNKVVWTVKELNPGESLQYKVLVRAQTPGQFTNNVVVKSCSDCGTCTSCAEATTYWKGVAATHMCVVDTCDPVCVGENTVYRICVTNRGSAEDTNVSLMLKFSKELQPVSFSGPTKGTITGNTVVFDSLPRLGSKETVEFSVTLKAVSAGDARGEAILSSDTLTVPVSDTENTHIY","length":547,"molWeight":58680,"crc64":"817BA5DC7FEA65D4","md5":"755A8D9BA818BAEAE8E27915F51293C4"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"SUBUNIT":1,"SUBCELLULAR LOCATION":1,"DEVELOPMENTAL STAGE":1,"CAUTION":1},"countByFeatureType":{"Signal":1,"Propeptide":1,"Chain":1,"Region":1,"Compositional bias":2},"uniParcId":"UPI0000130CC6"}},{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"P0CE20","secondaryAccessions":["P08788","P10554"],"uniProtkbId":"GP8D_CHLTH","entryAudit":{"firstPublicDate":"2010-03-02","lastAnnotationUpdateDate":"2026-11-04","lastSequenceUpdateDate":"2010-03-02","entryVersion":61,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Chlamydia trachomatis","taxonId":813,"lineage":["Bacteria","Pseudomonadati","Chlamydiota","Chlamydiia","Chlamydiales","Chlamydiaceae","Chlamydia/Chlamydophila group","Chlamydia"]},"proteinExistence":"3: Inferred from homology","proteinDescription":{"recommendedName":{"fullName":{"value":"Virulence plasmid integrase pGP8-D"}},"alternativeNames":[{"fullName":{"value":"Protein N-1/N-2"}}]},"comments":[{"texts":[{"value":"pGP8-D is required for growth within mammalian cells"}],"commentType":"MISCELLANEOUS"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Belongs to the 'phage' integrase family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":330,"modifier":"EXACT"}},"description":"Virulence plasmid integrase pGP8-D","featureId":"PRO_0000197566"},{"type":"Domain","location":{"start":{"value":39,"modifier":"EXACT"},"end":{"value":124,"modifier":"EXACT"}},"description":"Core-binding (CB)","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU01248"}]},{"type":"Domain","location":{"start":{"value":152,"modifier":"EXACT"},"end":{"value":327,"modifier":"EXACT"}},"description":"Tyr recombinase","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU01246"}]},{"type":"Active site","location":{"start":{"value":189,"modifier":"EXACT"},"end":{"value":189,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU01246"}]},{"type":"Active site","location":{"start":{"value":214,"modifier":"EXACT"},"end":{"value":214,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU01246"}]},{"type":"Active site","location":{"start":{"value":279,"modifier":"EXACT"},"end":{"value":279,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU01246"}]},{"type":"Active site","location":{"start":{"value":282,"modifier":"EXACT"},"end":{"value":282,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU01246"}]},{"type":"Active site","location":{"start":{"value":305,"modifier":"EXACT"},"end":{"value":305,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU01246"}]},{"type":"Active site","location":{"start":{"value":314,"modifier":"EXACT"},"end":{"value":314,"modifier":"EXACT"}},"description":"O-(3'-phospho-DNA)-tyrosine intermediate","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU01246"}]}],"geneLocations":[{"value":"pLGV440","geneEncodingType":"Plasmid"},{"value":"pCHL1","geneEncodingType":"Plasmid"}],"keywords":[{"id":"KW-0229","category":"Biological process","name":"DNA integration"},{"id":"KW-0233","category":"Biological process","name":"DNA recombination"},{"id":"KW-0238","category":"Molecular function","name":"DNA-binding"},{"id":"KW-0614","category":"Technical term","name":"Plasmid"},{"id":"KW-1179","category":"Biological process","name":"Viral genome integration"},{"id":"KW-1160","category":"Biological process","name":"Virus entry into host cell"}],"references":[{"referenceNumber":1,"citation":{"id":"2836808","citationType":"journal article","authors":["Hatt C.","Ward M.E.","Clarke I.N."],"citationCrossReferences":[{"database":"PubMed","id":"2836808"},{"database":"DOI","id":"10.1093/nar/16.9.4053"}],"title":"Analysis of the entire nucleotide sequence of the cryptic plasmid of Chlamydia trachomatis serovar L1. Evidence for involvement in DNA replication.","publicationDate":"1988","journal":"Nucleic Acids Res.","firstPage":"4053","lastPage":"4067","volume":"16"},"referencePositions":["NUCLEOTIDE SEQUENCE [GENOMIC DNA]"],"referenceComments":[{"value":"L1/440/LN","type":"STRAIN"},{"value":"pLGV440","type":"PLASMID"}]},{"referenceNumber":2,"citation":{"id":"CI-CODQ7TMJQKFN6","citationType":"submission","authors":["Hatt C."],"publicationDate":"APR-1994","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["SEQUENCE REVISION"]},{"referenceNumber":3,"citation":{"id":"2194229","citationType":"journal article","authors":["Comanducci M.","Ricci S.","Cevenini R.","Ratti G."],"citationCrossReferences":[{"database":"PubMed","id":"2194229"},{"database":"DOI","id":"10.1016/0147-619x(90)90034-a"}],"title":"Diversity of the Chlamydia trachomatis common plasmid in biovars with different pathogenicity.","publicationDate":"1990","journal":"Plasmid","firstPage":"149","lastPage":"154","volume":"23"},"referencePositions":["NUCLEOTIDE SEQUENCE [GENOMIC DNA]"],"referenceComments":[{"value":"D/GO/86","type":"STRAIN"},{"value":"pCHL1","type":"PLASMID"}]},{"referenceNumber":4,"citation":{"id":"7683369","citationType":"journal article","authors":["Ricci S.","Cevenini R.","Cosco E.","Comanducci M.","Ratti G.","Scarlato V."],"citationCrossReferences":[{"database":"PubMed","id":"7683369"},{"database":"DOI","id":"10.1007/bf00279434"}],"title":"Transcriptional analysis of the Chlamydia trachomatis plasmid pCT identifies temporally regulated transcripts, anti-sense RNA and sigma 70-selected promoters.","publicationDate":"1993","journal":"Mol. Gen. Genet.","firstPage":"318","lastPage":"326","volume":"237"},"referencePositions":["NUCLEOTIDE SEQUENCE [GENOMIC DNA]"],"referenceComments":[{"value":"pCHL1","type":"PLASMID"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"X07547","properties":[{"key":"ProteinId","value":"CAA30420.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"X06707","properties":[{"key":"ProteinId","value":"CAA29891.2"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"J03321","properties":[{"key":"ProteinId","value":"AAA91568.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"PIR","id":"H37386","properties":[{"key":"EntryName","value":"H37386"}]},{"database":"PIR","id":"S01181","properties":[{"key":"EntryName","value":"S01181"}]},{"database":"RefSeq","id":"WP_010889883.1","properties":[{"key":"NucleotideSequenceId","value":"NC_001372.1"}]},{"database":"AlphaFoldDB","id":"P0CE20","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"P0CE20","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"ACYISLT","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"GO","id":"GO:0003677","properties":[{"key":"GoTerm","value":"F:DNA binding"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0015074","properties":[{"key":"GoTerm","value":"P:DNA integration"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0006310","properties":[{"key":"GoTerm","value":"P:DNA recombination"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"CDD","id":"cd00397","properties":[{"key":"EntryName","value":"DNA_BRE_C"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.10.443.10","properties":[{"key":"EntryName","value":"Intergrase catalytic core"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR044068","properties":[{"key":"EntryName","value":"CB"}]},{"database":"InterPro","id":"IPR011010","properties":[{"key":"EntryName","value":"DNA_brk_join_enz"}]},{"database":"InterPro","id":"IPR013762","properties":[{"key":"EntryName","value":"Integrase-like_cat_sf"}]},{"database":"InterPro","id":"IPR002104","properties":[{"key":"EntryName","value":"Integrase_catalytic"}]},{"database":"InterPro","id":"IPR050090","properties":[{"key":"EntryName","value":"XerCD-like"}]},{"database":"PANTHER","id":"PTHR30349","properties":[{"key":"EntryName","value":"PHAGE INTEGRASE-RELATED"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00589","properties":[{"key":"EntryName","value":"Phage_integrase"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF56349","properties":[{"key":"EntryName","value":"DNA breaking-rejoining enzymes"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS51900","properties":[{"key":"EntryName","value":"CB"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS51898","properties":[{"key":"EntryName","value":"TYR_RECOMBINASE"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MGKGILSLQQEMSLEYSEKSYQEVLKIRQESYWKRMKSFSLFEVIMHWTASLNKHTCRSYRGSFLSLEKIGLLSLDMNLQEFSLLNHNLILDAIKKVSSAKTSWTEGTKQVRAASYISLTRFLNRMTQGIVAIAQPSKQENSRTFFKTREIVKTDAMNSLQTASFLKELKKINARDWLIAQTMLQGGKRSSEVLSLEISQICFQQATISFSQLKNRQTEKRIIITYPQKFMHFLQEYIGQRRGFVFVTRSGKMVGLRQIARTFSQAGLQAAIPFKITPHVLRATAVTEYKRLGCSDSDIMKVTGHATAKMIFAYDKSSREDNASKKMALI","length":330,"molWeight":37791,"crc64":"A2E52C2C221FC1BB","md5":"6AEC0A65D4352359E737D46535E62259"},"extraAttributes":{"countByCommentType":{"MISCELLANEOUS":1,"SIMILARITY":1},"countByFeatureType":{"Chain":1,"Domain":2,"Active site":6},"uniParcId":"UPI000002C7DB"}},{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"P10559","secondaryAccessions":["P08786"],"uniProtkbId":"GP5D_CHLTH","entryAudit":{"firstPublicDate":"1989-07-01","lastAnnotationUpdateDate":"2026-11-04","lastSequenceUpdateDate":"2001-01-11","entryVersion":108,"sequenceVersion":2},"annotationScore":2.0,"organism":{"scientificName":"Chlamydia trachomatis","taxonId":813,"lineage":["Bacteria","Pseudomonadati","Chlamydiota","Chlamydiia","Chlamydiales","Chlamydiaceae","Chlamydia/Chlamydophila group","Chlamydia"]},"proteinExistence":"3: Inferred from homology","proteinDescription":{"recommendedName":{"fullName":{"value":"Virulence plasmid ParA family protein pGP5-D"}},"alternativeNames":[{"fullName":{"value":"Protein P-9"}}]},"comments":[{"texts":[{"value":"Required for growth within mammalian cells"}],"commentType":"FUNCTION"},{"texts":[{"value":"The sequence shown is that of plasmid pLGV440"}],"commentType":"MISCELLANEOUS"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Belongs to the ParA family"}],"commentType":"SIMILARITY"},{"commentType":"SEQUENCE CAUTION","sequenceCautionType":"Erroneous initiation","sequence":"AAA91573.1","evidences":[{"evidenceCode":"ECO:0000305"}]},{"commentType":"SEQUENCE CAUTION","sequenceCautionType":"Erroneous initiation","sequence":"CAA29896.1","evidences":[{"evidenceCode":"ECO:0000305"}]},{"commentType":"SEQUENCE CAUTION","sequenceCautionType":"Erroneous initiation","sequence":"CAA30425.1","evidences":[{"evidenceCode":"ECO:0000305"}]}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":264,"modifier":"EXACT"}},"description":"Virulence plasmid ParA family protein pGP5-D","featureId":"PRO_0000201990"},{"type":"Binding site","location":{"start":{"value":9,"modifier":"EXACT"},"end":{"value":16,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:30616"}],"evidences":[{"evidenceCode":"ECO:0000255"}],"ligand":{"name":"ATP","id":"ChEBI:CHEBI:30616"}},{"type":"Natural variant","location":{"start":{"value":56,"modifier":"EXACT"},"end":{"value":56,"modifier":"EXACT"}},"description":"in plasmid pCHL1","featureId":"","alternativeSequence":{"originalSequence":"N","alternativeSequences":["D"]}},{"type":"Natural variant","location":{"start":{"value":90,"modifier":"EXACT"},"end":{"value":90,"modifier":"EXACT"}},"description":"in plasmid pCHL1","featureId":"","alternativeSequence":{"originalSequence":"L","alternativeSequences":["S"]}}],"geneLocations":[{"value":"pLGV440","geneEncodingType":"Plasmid"},{"value":"pCHL1","geneEncodingType":"Plasmid"}],"keywords":[{"id":"KW-0067","category":"Ligand","name":"ATP-binding"},{"id":"KW-0547","category":"Ligand","name":"Nucleotide-binding"},{"id":"KW-0614","category":"Technical term","name":"Plasmid"}],"references":[{"referenceNumber":1,"citation":{"id":"2845228","citationType":"journal article","authors":["Comanducci M.","Ricci S.","Ratti G."],"citationCrossReferences":[{"database":"PubMed","id":"2845228"},{"database":"DOI","id":"10.1111/j.1365-2958.1988.tb00060.x"}],"title":"The structure of a plasmid of Chlamydia trachomatis believed to be required for growth within mammalian cells.","publicationDate":"1988","journal":"Mol. Microbiol.","firstPage":"531","lastPage":"538","volume":"2"},"referencePositions":["NUCLEOTIDE SEQUENCE [GENOMIC DNA]"],"referenceComments":[{"value":"L2/434/Bu","type":"STRAIN"},{"value":"pLGV440","type":"PLASMID"}]},{"referenceNumber":2,"citation":{"id":"2836808","citationType":"journal article","authors":["Hatt C.","Ward M.E.","Clarke I.N."],"citationCrossReferences":[{"database":"PubMed","id":"2836808"},{"database":"DOI","id":"10.1093/nar/16.9.4053"}],"title":"Analysis of the entire nucleotide sequence of the cryptic plasmid of Chlamydia trachomatis serovar L1. Evidence for involvement in DNA replication.","publicationDate":"1988","journal":"Nucleic Acids Res.","firstPage":"4053","lastPage":"4067","volume":"16"},"referencePositions":["NUCLEOTIDE SEQUENCE [GENOMIC DNA]"],"referenceComments":[{"value":"L1/440/LN","type":"STRAIN"},{"value":"pLGV440","type":"PLASMID"}]},{"referenceNumber":3,"citation":{"id":"2194229","citationType":"journal article","authors":["Comanducci M.","Ricci S.","Cevenini R.","Ratti G."],"citationCrossReferences":[{"database":"PubMed","id":"2194229"},{"database":"DOI","id":"10.1016/0147-619x(90)90034-a"}],"title":"Diversity of the Chlamydia trachomatis common plasmid in biovars with different pathogenicity.","publicationDate":"1990","journal":"Plasmid","firstPage":"149","lastPage":"154","volume":"23"},"referencePositions":["NUCLEOTIDE SEQUENCE [GENOMIC DNA]"],"referenceComments":[{"value":"D/GO/86","type":"STRAIN"},{"value":"pCHL1","type":"PLASMID"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"X07547","properties":[{"key":"ProteinId","value":"CAA30425.1"},{"key":"Status","value":"ALT_INIT"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"X06707","properties":[{"key":"ProteinId","value":"CAA29896.1"},{"key":"Status","value":"ALT_INIT"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"J03321","properties":[{"key":"ProteinId","value":"AAA91573.1"},{"key":"Status","value":"ALT_INIT"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"PIR","id":"S01923","properties":[{"key":"EntryName","value":"S01923"}]},{"database":"RefSeq","id":"WP_015506340.1","properties":[{"key":"NucleotideSequenceId","value":"NC_010286.1"}]},{"database":"AlphaFoldDB","id":"P10559","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"P10559","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"ACDSIII","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"CDD","id":"cd02042","properties":[{"key":"EntryName","value":"ParAB_family"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.40.50.300","properties":[{"key":"EntryName","value":"P-loop containing nucleotide triphosphate hydrolases"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR025669","properties":[{"key":"EntryName","value":"AAA_dom"}]},{"database":"InterPro","id":"IPR050678","properties":[{"key":"EntryName","value":"DNA_Partitioning_ATPase"}]},{"database":"InterPro","id":"IPR027417","properties":[{"key":"EntryName","value":"P-loop_NTPase"}]},{"database":"PANTHER","id":"PTHR13696","properties":[{"key":"EntryName","value":"P-LOOP CONTAINING NUCLEOSIDE TRIPHOSPHATE HYDROLASE"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR13696:SF52","properties":[{"key":"EntryName","value":"PARA FAMILY PROTEIN CT_582"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF13614","properties":[{"key":"EntryName","value":"AAA_31"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF52540","properties":[{"key":"EntryName","value":"P-loop containing nucleoside triphosphate hydrolases"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MHTLVFCSFKGGTGKTTLSLNVGCNLAQFLGKKVLLADLDPQSNLSSGLGASVRSNQKGLHDIVYTSNDLKSIICETKKDSVDLIPASFLSEQFRELDIHRGPSNNLKLFLNEYCAPFYDICIIDTPPSLGGLTKEAFVAGDKLIACLTPEPFSILGLQKIREFLSSVGKPEEEHILGIALSFWDDRNSTNQMYIDIIESIYKNKLFSTKIRRDISLSRSLLKEDSVANVYPNSRAAEDILKLTHEIANILHIEYERDYSQRTT","length":264,"molWeight":29481,"crc64":"2DF42A0F84976458","md5":"F863B7BBCC5F19571995F1B90FEBE82E"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"MISCELLANEOUS":1,"SIMILARITY":1,"SEQUENCE CAUTION":3},"countByFeatureType":{"Chain":1,"Binding site":1,"Natural variant":2},"uniParcId":"UPI000012B94F"}},{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"P10560","secondaryAccessions":["P08787","Q46433"],"uniProtkbId":"GP6D_CHLTH","entryAudit":{"firstPublicDate":"1989-07-01","lastAnnotationUpdateDate":"2026-11-04","lastSequenceUpdateDate":"1989-07-01","entryVersion":91,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Chlamydia trachomatis","taxonId":813,"lineage":["Bacteria","Pseudomonadati","Chlamydiota","Chlamydiia","Chlamydiales","Chlamydiaceae","Chlamydia/Chlamydophila group","Chlamydia"]},"proteinExistence":"3: Inferred from homology","proteinDescription":{"recommendedName":{"fullName":{"value":"Virulence plasmid protein pGP6-D"}},"alternativeNames":[{"fullName":{"value":"Protein P-10"}}]},"comments":[{"texts":[{"value":"pGP6-D is required for growth within mammalian cells"}],"commentType":"MISCELLANEOUS"},{"texts":[{"value":"The sequence shown is that of plasmid pLGV440"}],"commentType":"MISCELLANEOUS"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Belongs to the UPF0137 (pGP6-D) family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":247,"modifier":"EXACT"}},"description":"Virulence plasmid protein pGP6-D","featureId":"PRO_0000220776"},{"type":"Natural variant","location":{"start":{"value":9,"modifier":"EXACT"},"end":{"value":9,"modifier":"EXACT"}},"description":"in plasmid pCHL1 and plasmid pCTT1","featureId":"","alternativeSequence":{"originalSequence":"N","alternativeSequences":["D"]}},{"type":"Natural variant","location":{"start":{"value":47,"modifier":"EXACT"},"end":{"value":47,"modifier":"EXACT"}},"description":"in plasmid pCHL1 and plasmid pCTT1","featureId":"","alternativeSequence":{"originalSequence":"Q","alternativeSequences":["R"]}},{"type":"Natural variant","location":{"start":{"value":183,"modifier":"EXACT"},"end":{"value":186,"modifier":"EXACT"}},"description":"in plasmid pCTT1","featureId":"","alternativeSequence":{"originalSequence":"VLDQ","alternativeSequences":["CWIE"]}},{"type":"Natural variant","location":{"start":{"value":194,"modifier":"EXACT"},"end":{"value":194,"modifier":"EXACT"}},"description":"in plasmid pCTT1","featureId":"","alternativeSequence":{"originalSequence":"K","alternativeSequences":["T"]}},{"type":"Natural variant","location":{"start":{"value":205,"modifier":"EXACT"},"end":{"value":205,"modifier":"EXACT"}},"description":"in plasmid pCTT1","featureId":"","alternativeSequence":{"originalSequence":"S","alternativeSequences":["L"]}},{"type":"Natural variant","location":{"start":{"value":222,"modifier":"EXACT"},"end":{"value":222,"modifier":"EXACT"}},"description":"in plasmid pCTT1","featureId":"","alternativeSequence":{"originalSequence":"M","alternativeSequences":["I"]}}],"geneLocations":[{"value":"pLGV440","geneEncodingType":"Plasmid"},{"value":"pCHL1","geneEncodingType":"Plasmid"},{"value":"pCTT1","geneEncodingType":"Plasmid"}],"keywords":[{"id":"KW-0614","category":"Technical term","name":"Plasmid"}],"references":[{"referenceNumber":1,"citation":{"id":"2845228","citationType":"journal article","authors":["Comanducci M.","Ricci S.","Ratti G."],"citationCrossReferences":[{"database":"PubMed","id":"2845228"},{"database":"DOI","id":"10.1111/j.1365-2958.1988.tb00060.x"}],"title":"The structure of a plasmid of Chlamydia trachomatis believed to be required for growth within mammalian cells.","publicationDate":"1988","journal":"Mol. Microbiol.","firstPage":"531","lastPage":"538","volume":"2"},"referencePositions":["NUCLEOTIDE SEQUENCE [GENOMIC DNA]"],"referenceComments":[{"value":"L2/434/Bu","type":"STRAIN"},{"value":"pLGV440","type":"PLASMID"}]},{"referenceNumber":2,"citation":{"id":"2836808","citationType":"journal article","authors":["Hatt C.","Ward M.E.","Clarke I.N."],"citationCrossReferences":[{"database":"PubMed","id":"2836808"},{"database":"DOI","id":"10.1093/nar/16.9.4053"}],"title":"Analysis of the entire nucleotide sequence of the cryptic plasmid of Chlamydia trachomatis serovar L1. Evidence for involvement in DNA replication.","publicationDate":"1988","journal":"Nucleic Acids Res.","firstPage":"4053","lastPage":"4067","volume":"16"},"referencePositions":["NUCLEOTIDE SEQUENCE [GENOMIC DNA]"],"referenceComments":[{"value":"L1/440/LN","type":"STRAIN"},{"value":"pLGV440","type":"PLASMID"}]},{"referenceNumber":3,"citation":{"id":"2194229","citationType":"journal article","authors":["Comanducci M.","Ricci S.","Cevenini R.","Ratti G."],"citationCrossReferences":[{"database":"PubMed","id":"2194229"},{"database":"DOI","id":"10.1016/0147-619x(90)90034-a"}],"title":"Diversity of the Chlamydia trachomatis common plasmid in biovars with different pathogenicity.","publicationDate":"1990","journal":"Plasmid","firstPage":"149","lastPage":"154","volume":"23"},"referencePositions":["NUCLEOTIDE SEQUENCE [GENOMIC DNA]"],"referenceComments":[{"value":"D/GO/86","type":"STRAIN"},{"value":"pCHL1","type":"PLASMID"}]},{"referenceNumber":4,"citation":{"id":"3444859","citationType":"journal article","authors":["Sriprakash K.S.","Macavoy E.S."],"citationCrossReferences":[{"database":"PubMed","id":"3444859"},{"database":"DOI","id":"10.1016/0147-619x(87)90063-1"}],"title":"Characterization and sequence of a plasmid from the trachoma biovar of Chlamydia trachomatis.","publicationDate":"1987","journal":"Plasmid","firstPage":"205","lastPage":"214","volume":"18"},"referencePositions":["NUCLEOTIDE SEQUENCE [GENOMIC DNA]"],"referenceComments":[{"value":"Serotype B","type":"STRAIN"},{"value":"pCTT1","type":"PLASMID"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"X07547","properties":[{"key":"ProteinId","value":"CAA30426.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"X06707","properties":[{"key":"ProteinId","value":"CAA29897.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"J03321","properties":[{"key":"ProteinId","value":"AAA91574.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"M19487","properties":[{"key":"ProteinId","value":"AAB02591.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"PIR","id":"S01924","properties":[{"key":"EntryName","value":"S01924"}]},{"database":"RefSeq","id":"WP_010889889.1","properties":[{"key":"NucleotideSequenceId","value":"NZ_JBEQOY010000002.1"}]},{"database":"RefSeq","id":"WP_012209819.1","properties":[{"key":"NucleotideSequenceId","value":"NC_010286.1"}]},{"database":"AlphaFoldDB","id":"P10560","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"AIQKQHV","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"InterPro","id":"IPR005350","properties":[{"key":"EntryName","value":"UPF0137"}]},{"database":"Pfam","id":"PF03677","properties":[{"key":"EntryName","value":"UPF0137"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MNKLKKEANVFFKKNQTAASLDFKKTLPSIELFSATLNSEESQSLDQLFLSESQNYSDEEFYQEDILAVKLLTGQIKSIQKQHVLLLGEKIYNARKILSKDHFSSTTFSSWIELVFRTKSSAYNALAYYELFINLPNQTLQKEFQSIPYKSAYILAARKGDLKTKVDVIGKVCGMSNSSAIRVLDQFLPSSRNKDVRETIDKSDSEKNRQLSDFLIEILRIMCSGVSLSSYNENLLQQLFELFKQKS","length":247,"molWeight":28307,"crc64":"F1FA11F29037C221","md5":"604912E0005808F26E94FBB9D8E33845"},"extraAttributes":{"countByCommentType":{"MISCELLANEOUS":2,"SIMILARITY":1},"countByFeatureType":{"Chain":1,"Natural variant":6},"uniParcId":"UPI000011D867"}},{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"P0CE19","secondaryAccessions":["P10561","Q46427"],"uniProtkbId":"GP7D_CHLTH","entryAudit":{"firstPublicDate":"2010-03-02","lastAnnotationUpdateDate":"2026-11-04","lastSequenceUpdateDate":"2010-03-02","entryVersion":58,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Chlamydia trachomatis","taxonId":813,"lineage":["Bacteria","Pseudomonadati","Chlamydiota","Chlamydiia","Chlamydiales","Chlamydiaceae","Chlamydia/Chlamydophila group","Chlamydia"]},"proteinExistence":"3: Inferred from homology","proteinDescription":{"recommendedName":{"fullName":{"value":"Virulence plasmid integrase pGP7-D"}},"alternativeNames":[{"fullName":{"value":"Protein P-11"}}]},"comments":[{"texts":[{"value":"pGP7-D is required for growth within mammalian cells"}],"commentType":"MISCELLANEOUS"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Belongs to the 'phage' integrase family"}],"commentType":"SIMILARITY"},{"commentType":"SEQUENCE CAUTION","sequenceCautionType":"Frameshift","sequence":"AAB02584.1","evidences":[{"evidenceCode":"ECO:0000305"}]},{"commentType":"SEQUENCE CAUTION","sequenceCautionType":"Erroneous initiation","sequence":"AAB02592.1","evidences":[{"evidenceCode":"ECO:0000305"}]}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":305,"modifier":"EXACT"}},"description":"Virulence plasmid integrase pGP7-D","featureId":"PRO_0000197563"},{"type":"Domain","location":{"start":{"value":13,"modifier":"EXACT"},"end":{"value":99,"modifier":"EXACT"}},"description":"Core-binding (CB)","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU01248"}]},{"type":"Domain","location":{"start":{"value":127,"modifier":"EXACT"},"end":{"value":305,"modifier":"EXACT"}},"description":"Tyr recombinase","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU01246"}]},{"type":"Active site","location":{"start":{"value":188,"modifier":"EXACT"},"end":{"value":188,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU01246"}]},{"type":"Active site","location":{"start":{"value":257,"modifier":"EXACT"},"end":{"value":257,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU01246"}]},{"type":"Active site","location":{"start":{"value":289,"modifier":"EXACT"},"end":{"value":289,"modifier":"EXACT"}},"description":"O-(3'-phospho-DNA)-tyrosine intermediate","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU01246"}]},{"type":"Natural variant","location":{"start":{"value":28,"modifier":"EXACT"},"end":{"value":28,"modifier":"EXACT"}},"description":"in plasmid pCHL1","featureId":"","alternativeSequence":{"originalSequence":"H","alternativeSequences":["Y"]}},{"type":"Natural variant","location":{"start":{"value":244,"modifier":"EXACT"},"end":{"value":244,"modifier":"EXACT"}},"description":"in plasmid pCHL1 and plasmid pCTT1","featureId":"","alternativeSequence":{"originalSequence":"Y","alternativeSequences":["H"]}},{"type":"Natural variant","location":{"start":{"value":296,"modifier":"EXACT"},"end":{"value":296,"modifier":"EXACT"}},"description":"in plasmid pCHL1","featureId":"","alternativeSequence":{"originalSequence":"S","alternativeSequences":["I"]}},{"type":"Natural variant","location":{"start":{"value":303,"modifier":"EXACT"},"end":{"value":303,"modifier":"EXACT"}},"description":"in plasmid pCHL1 and plasmid pCTT1","featureId":"","alternativeSequence":{"originalSequence":"P","alternativeSequences":["T"]}}],"geneLocations":[{"value":"pLGV440","geneEncodingType":"Plasmid"},{"value":"pCHL1","geneEncodingType":"Plasmid"},{"value":"pCTT1","geneEncodingType":"Plasmid"}],"keywords":[{"id":"KW-0229","category":"Biological process","name":"DNA integration"},{"id":"KW-0233","category":"Biological process","name":"DNA recombination"},{"id":"KW-0238","category":"Molecular function","name":"DNA-binding"},{"id":"KW-0614","category":"Technical term","name":"Plasmid"},{"id":"KW-1179","category":"Biological process","name":"Viral genome integration"},{"id":"KW-1160","category":"Biological process","name":"Virus entry into host cell"}],"references":[{"referenceNumber":1,"citation":{"id":"2836808","citationType":"journal article","authors":["Hatt C.","Ward M.E.","Clarke I.N."],"citationCrossReferences":[{"database":"PubMed","id":"2836808"},{"database":"DOI","id":"10.1093/nar/16.9.4053"}],"title":"Analysis of the entire nucleotide sequence of the cryptic plasmid of Chlamydia trachomatis serovar L1. Evidence for involvement in DNA replication.","publicationDate":"1988","journal":"Nucleic Acids Res.","firstPage":"4053","lastPage":"4067","volume":"16"},"referencePositions":["NUCLEOTIDE SEQUENCE [GENOMIC DNA]"],"referenceComments":[{"value":"L1/440/LN","type":"STRAIN"},{"value":"pLGV440","type":"PLASMID"}]},{"referenceNumber":2,"citation":{"id":"CI-CODQ7TMJQKFN6","citationType":"submission","authors":["Hatt C."],"publicationDate":"APR-1994","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["SEQUENCE REVISION"]},{"referenceNumber":3,"citation":{"id":"2194229","citationType":"journal article","authors":["Comanducci M.","Ricci S.","Cevenini R.","Ratti G."],"citationCrossReferences":[{"database":"PubMed","id":"2194229"},{"database":"DOI","id":"10.1016/0147-619x(90)90034-a"}],"title":"Diversity of the Chlamydia trachomatis common plasmid in biovars with different pathogenicity.","publicationDate":"1990","journal":"Plasmid","firstPage":"149","lastPage":"154","volume":"23"},"referencePositions":["NUCLEOTIDE SEQUENCE [GENOMIC DNA]"],"referenceComments":[{"value":"D/GO/86","type":"STRAIN"},{"value":"pCHL1","type":"PLASMID"}]},{"referenceNumber":4,"citation":{"id":"3444859","citationType":"journal article","authors":["Sriprakash K.S.","Macavoy E.S."],"citationCrossReferences":[{"database":"PubMed","id":"3444859"},{"database":"DOI","id":"10.1016/0147-619x(87)90063-1"}],"title":"Characterization and sequence of a plasmid from the trachoma biovar of Chlamydia trachomatis.","publicationDate":"1987","journal":"Plasmid","firstPage":"205","lastPage":"214","volume":"18"},"referencePositions":["NUCLEOTIDE SEQUENCE [GENOMIC DNA]"],"referenceComments":[{"value":"Serotype B","type":"STRAIN"},{"value":"pCTT1","type":"PLASMID"}]},{"referenceNumber":5,"citation":{"id":"7683369","citationType":"journal article","authors":["Ricci S.","Cevenini R.","Cosco E.","Comanducci M.","Ratti G.","Scarlato V."],"citationCrossReferences":[{"database":"PubMed","id":"7683369"},{"database":"DOI","id":"10.1007/bf00279434"}],"title":"Transcriptional analysis of the Chlamydia trachomatis plasmid pCT identifies temporally regulated transcripts, anti-sense RNA and sigma 70-selected promoters.","publicationDate":"1993","journal":"Mol. Gen. Genet.","firstPage":"318","lastPage":"326","volume":"237"},"referencePositions":["NUCLEOTIDE SEQUENCE [GENOMIC DNA]"],"referenceComments":[{"value":"pCHL1","type":"PLASMID"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"X06707","properties":[{"key":"ProteinId","value":"CAA29890.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"J03321","properties":[{"key":"ProteinId","value":"AAA91567.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"M19487","properties":[{"key":"ProteinId","value":"AAB02592.1"},{"key":"Status","value":"ALT_INIT"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"M19487","properties":[{"key":"ProteinId","value":"AAB02584.1"},{"key":"Status","value":"ALT_FRAME"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"PIR","id":"S01875","properties":[{"key":"EntryName","value":"S01875"}]},{"database":"RefSeq","id":"WP_010889882.1","properties":[{"key":"NucleotideSequenceId","value":"NZ_CVNT01000004.1"}]},{"database":"RefSeq","id":"WP_012209813.1","properties":[{"key":"NucleotideSequenceId","value":"NC_010286.1"}]},{"database":"AlphaFoldDB","id":"P0CE19","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"P0CE19","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"AINQVYY","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"GO","id":"GO:0003677","properties":[{"key":"GoTerm","value":"F:DNA binding"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0015074","properties":[{"key":"GoTerm","value":"P:DNA integration"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0006310","properties":[{"key":"GoTerm","value":"P:DNA recombination"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"CDD","id":"cd00397","properties":[{"key":"EntryName","value":"DNA_BRE_C"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.10.443.10","properties":[{"key":"EntryName","value":"Intergrase catalytic core"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR044068","properties":[{"key":"EntryName","value":"CB"}]},{"database":"InterPro","id":"IPR011010","properties":[{"key":"EntryName","value":"DNA_brk_join_enz"}]},{"database":"InterPro","id":"IPR013762","properties":[{"key":"EntryName","value":"Integrase-like_cat_sf"}]},{"database":"InterPro","id":"IPR002104","properties":[{"key":"EntryName","value":"Integrase_catalytic"}]},{"database":"Pfam","id":"PF00589","properties":[{"key":"EntryName","value":"Phage_integrase"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF56349","properties":[{"key":"EntryName","value":"DNA breaking-rejoining enzymes"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS51900","properties":[{"key":"EntryName","value":"CB"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS51898","properties":[{"key":"EntryName","value":"TYR_RECOMBINASE"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MGSMAFHKSRLFLTFGDASEIWLSTLSHLTRKNYASGINFLVSLEILDLSETLIKAISLDHSESLFKIKSLDVFNGKVVSEASKQARAACYISFTKFLYRLTKGYIKPAIPLKDFGNTTFFKIRDKIKTESISKQEWTVFFEALRIVNYRDYLIGKLIVQGIRKLDEILSLRTDDLFFASNQISFRIKKRQNKETKILITFPISLMEELQKYTCGRNGRVFVSKIGIPVTTSQVAHNFRLAEFYSAMKIKITPRVLRASALIHLKQIGLKDEEIMRISCLSSRQSVCSYCSGEEVSPLVQTPPIL","length":305,"molWeight":34806,"crc64":"048C77FB84A42C19","md5":"DFB61C71A5F65E1FA849DCA6FA3FE3F1"},"extraAttributes":{"countByCommentType":{"MISCELLANEOUS":1,"SIMILARITY":1,"SEQUENCE CAUTION":2},"countByFeatureType":{"Chain":1,"Domain":2,"Active site":3,"Natural variant":4},"uniParcId":"UPI000012B95D"}},{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"P18587","uniProtkbId":"SRPL_CHLTH","entryAudit":{"firstPublicDate":"1990-11-01","lastAnnotationUpdateDate":"2026-11-04","lastSequenceUpdateDate":"1990-11-01","entryVersion":67,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Chlamydia trachomatis","taxonId":813,"lineage":["Bacteria","Pseudomonadati","Chlamydiota","Chlamydiia","Chlamydiales","Chlamydiaceae","Chlamydia/Chlamydophila group","Chlamydia"]},"proteinExistence":"4: Predicted","proteinDescription":{"recommendedName":{"fullName":{"value":"Sulfur-rich protein, serovars L1/L3"}},"alternativeNames":[{"fullName":{"value":"15 kDa cysteine-rich outer membrane protein"}},{"fullName":{"value":"Cysteine-rich protein A"}}]},"genes":[{"geneName":{"value":"srp"},"synonyms":[{"value":"crpA"}]}],"comments":[{"commentType":"SUBCELLULAR LOCATION","note":{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11207561"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"14568950"}],"value":"Immunolocalizes to the inclusion membrane, the membrane that surrounds the intracellular parasite (PubMed:11207561). This protein is recognized by CD8+ T-cells in both human and mouse infections, suggesting it gains access to the host cytoplasm (PubMed:14568950)"}]},"subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Membrane","id":"SL-0162"},"topology":{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Multi-pass membrane protein","id":"SL-9909"}}]}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":150,"modifier":"EXACT"}},"description":"Sulfur-rich protein, serovars L1/L3","featureId":"PRO_0000207125"},{"type":"Transmembrane","location":{"start":{"value":43,"modifier":"EXACT"},"end":{"value":63,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":69,"modifier":"EXACT"},"end":{"value":89,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Region","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":20,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":20,"modifier":"EXACT"}},"description":"Polar residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]}],"keywords":[{"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"id":"KW-1133","category":"Domain","name":"Transmembrane helix"}],"references":[{"referenceNumber":1,"citation":{"id":"3066701","citationType":"journal article","authors":["Clarke I.N.","Ward M.E.","Lambden P.R."],"citationCrossReferences":[{"database":"PubMed","id":"3066701"},{"database":"DOI","id":"10.1016/0378-1119(88)90047-9"}],"title":"Molecular cloning and sequence analysis of a developmentally regulated cysteine-rich outer membrane protein from Chlamydia trachomatis.","publicationDate":"1988","journal":"Gene","firstPage":"307","lastPage":"314","volume":"71"},"referencePositions":["NUCLEOTIDE SEQUENCE [GENOMIC DNA]"],"referenceComments":[{"value":"L1/440/LN","type":"STRAIN"}]},{"referenceNumber":2,"citation":{"id":"1997423","citationType":"journal article","authors":["de la Maza L.M.","Fiedler T.J.","Carlson E.J.","Markoff B.A.","Peterson E.M."],"citationCrossReferences":[{"database":"PubMed","id":"1997423"},{"database":"DOI","id":"10.1128/iai.59.3.1196-1201.1991"}],"title":"Sequence diversity of the 60-kilodalton protein and of a putative 15-kilodalton protein between the trachoma and lymphogranuloma venereum biovars of Chlamydia trachomatis.","publicationDate":"1991","journal":"Infect. Immun.","firstPage":"1196","lastPage":"1201","volume":"59"},"referencePositions":["NUCLEOTIDE SEQUENCE [GENOMIC DNA]"],"referenceComments":[{"value":"L3/404","type":"STRAIN"}]},{"referenceNumber":3,"citation":{"id":"11207561","citationType":"journal article","authors":["Bannantine J.P.","Griffiths R.S.","Viratyosin W.","Brown W.J.","Rockey D.D."],"citationCrossReferences":[{"database":"PubMed","id":"11207561"},{"database":"DOI","id":"10.1046/j.1462-5822.2000.00029.x"}],"title":"A secondary structure motif predictive of protein localization to the chlamydial inclusion membrane.","publicationDate":"2000","journal":"Cell. Microbiol.","firstPage":"35","lastPage":"47","volume":"2"},"referencePositions":["LOCALIZATION TO INCLUSION MEMBRANES"],"referenceComments":[{"value":"L2/434/Bu","type":"STRAIN"}]},{"referenceNumber":4,"citation":{"id":"14568950","citationType":"journal article","authors":["Starnbach M.N.","Loomis W.P.","Ovendale P.","Regan D.","Hess B.","Alderson M.R.","Fling S.P."],"citationCrossReferences":[{"database":"PubMed","id":"14568950"},{"database":"DOI","id":"10.4049/jimmunol.171.9.4742"}],"title":"An inclusion membrane protein from Chlamydia trachomatis enters the MHC class I pathway and stimulates a CD8+ T cell response.","publicationDate":"2003","journal":"J. Immunol.","firstPage":"4742","lastPage":"4749","volume":"171"},"referencePositions":["RECOGNITION BY CD8+ T-CELLS"],"referenceComments":[{"value":"L2/434/Bu","type":"STRAIN"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"M35148","properties":[{"key":"ProteinId","value":"AAA23120.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"X54390","properties":[{"key":"ProteinId","value":"CAA38262.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"PIR","id":"JT0420","properties":[{"key":"EntryName","value":"JT0420"}]},{"database":"RefSeq","id":"WP_015505893.1","properties":[{"key":"NucleotideSequenceId","value":"NZ_CP142852.1"}]},{"database":"AlphaFoldDB","id":"P18587","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"AFQITMI","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"GO","id":"GO:0019867","properties":[{"key":"GoTerm","value":"C:outer membrane"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"InterPro","id":"IPR008436","properties":[{"key":"EntryName","value":"SRP-like"}]},{"database":"Pfam","id":"PF05745","properties":[{"key":"EntryName","value":"CRPA"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MSTVPVVQGAGSSNSAQDISTSSVPLTLQGRISNLLSSTAFKVGLVVMGLLLVMATIFLVSAASFVNPIYLAIPAIVGCVNICVGILSMEGYCSPERWSLCKKVLKASEDIIDDGQINNSNKVFTDERLNAIGGVVESLSRRNSLVDQTQ","length":150,"molWeight":15836,"crc64":"104D384C2332DB65","md5":"E48340C689E0D26CA663C17371327A34"},"extraAttributes":{"countByCommentType":{"SUBCELLULAR LOCATION":1},"countByFeatureType":{"Chain":1,"Transmembrane":2,"Region":1,"Compositional bias":1},"uniParcId":"UPI0000128474"}},{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"P26756","uniProtkbId":"SRPC_CHLTH","entryAudit":{"firstPublicDate":"1992-08-01","lastAnnotationUpdateDate":"2026-11-04","lastSequenceUpdateDate":"1992-08-01","entryVersion":65,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Chlamydia trachomatis","taxonId":813,"lineage":["Bacteria","Pseudomonadati","Chlamydiota","Chlamydiia","Chlamydiales","Chlamydiaceae","Chlamydia/Chlamydophila group","Chlamydia"]},"proteinExistence":"3: Inferred from homology","proteinDescription":{"recommendedName":{"fullName":{"value":"Sulfur-rich protein, serovar C"}},"alternativeNames":[{"fullName":{"value":"15 kDa cysteine-rich outer membrane protein"}},{"fullName":{"value":"Cysteine-rich protein A"}}]},"genes":[{"geneName":{"value":"srp"},"synonyms":[{"value":"crpA"}]}],"comments":[{"commentType":"SUBCELLULAR LOCATION","note":{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250"}],"value":"Immunolocalizes to the inclusion membrane, the membrane that surrounds the intracellular parasite. This protein is recognized by CD8+ T-cells in both human and mouse infections, suggesting it gains access to the host cytoplasm"}]},"subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Membrane","id":"SL-0162"},"topology":{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Multi-pass membrane protein","id":"SL-9909"}}]}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":152,"modifier":"EXACT"}},"description":"Sulfur-rich protein, serovar C","featureId":"PRO_0000207122"},{"type":"Transmembrane","location":{"start":{"value":43,"modifier":"EXACT"},"end":{"value":63,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":69,"modifier":"EXACT"},"end":{"value":89,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Region","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":20,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":20,"modifier":"EXACT"}},"description":"Polar residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]}],"keywords":[{"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"id":"KW-1133","category":"Domain","name":"Transmembrane helix"}],"references":[{"referenceNumber":1,"citation":{"id":"1997423","citationType":"journal article","authors":["de la Maza L.M.","Fiedler T.J.","Carlson E.J.","Markoff B.A.","Peterson E.M."],"citationCrossReferences":[{"database":"PubMed","id":"1997423"},{"database":"DOI","id":"10.1128/iai.59.3.1196-1201.1991"}],"title":"Sequence diversity of the 60-kilodalton protein and of a putative 15-kilodalton protein between the trachoma and lymphogranuloma venereum biovars of Chlamydia trachomatis.","publicationDate":"1991","journal":"Infect. Immun.","firstPage":"1196","lastPage":"1201","volume":"59"},"referencePositions":["NUCLEOTIDE SEQUENCE [GENOMIC DNA]"],"referenceComments":[{"value":"C/TW-3","type":"STRAIN"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"X54388","properties":[{"key":"ProteinId","value":"CAA38258.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"PIR","id":"F43584","properties":[{"key":"EntryName","value":"F43584"}]},{"database":"RefSeq","id":"WP_011324736.1","properties":[{"key":"NucleotideSequenceId","value":"NZ_CP016420.1"}]},{"database":"AlphaFoldDB","id":"P26756","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"P26756","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"AFQITMI","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"GO","id":"GO:0019867","properties":[{"key":"GoTerm","value":"C:outer membrane"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"InterPro","id":"IPR008436","properties":[{"key":"EntryName","value":"SRP-like"}]},{"database":"Pfam","id":"PF05745","properties":[{"key":"EntryName","value":"CRPA"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MSTVPVVQGAGSSNSAQDISTSSAPLTLKERISNLLSSTAFKVGLVVIGLLLVIATLIFLVSAASFVNAIYLVAIPAILGCVNICVGILSMEGHCSPERWILCKKVLKTSEDIIDDGQINNSNKVFTDERLNAIDGVVESLSRRNSLVDQTQ","length":152,"molWeight":16133,"crc64":"31D325CC0619A2F1","md5":"21378BDBE3E5D3003BB6F8BBC4AA0E95"},"extraAttributes":{"countByCommentType":{"SUBCELLULAR LOCATION":1},"countByFeatureType":{"Chain":1,"Transmembrane":2,"Region":1,"Compositional bias":1},"uniParcId":"UPI0000128470"}},{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"P26757","uniProtkbId":"SRPE_CHLTH","entryAudit":{"firstPublicDate":"1992-08-01","lastAnnotationUpdateDate":"2026-11-04","lastSequenceUpdateDate":"1992-08-01","entryVersion":68,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Chlamydia trachomatis","taxonId":813,"lineage":["Bacteria","Pseudomonadati","Chlamydiota","Chlamydiia","Chlamydiales","Chlamydiaceae","Chlamydia/Chlamydophila group","Chlamydia"]},"proteinExistence":"3: Inferred from homology","proteinDescription":{"recommendedName":{"fullName":{"value":"Sulfur-rich protein, serovar E"}},"alternativeNames":[{"fullName":{"value":"15 kDa cysteine-rich outer membrane protein"}},{"fullName":{"value":"Cysteine-rich protein A"}}]},"genes":[{"geneName":{"value":"srp"},"synonyms":[{"value":"crpA"}]}],"comments":[{"commentType":"SUBCELLULAR LOCATION","note":{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250"}],"value":"Immunolocalizes to the inclusion membrane, the membrane that surrounds the intracellular parasite. This protein is recognized by CD8+ T-cells in both human and mouse infections, suggesting it gains access to the host cytoplasm"}]},"subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Membrane","id":"SL-0162"},"topology":{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Multi-pass membrane protein","id":"SL-9909"}}]}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":151,"modifier":"EXACT"}},"description":"Sulfur-rich protein, serovar E","featureId":"PRO_0000207124"},{"type":"Transmembrane","location":{"start":{"value":43,"modifier":"EXACT"},"end":{"value":63,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":70,"modifier":"EXACT"},"end":{"value":90,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Region","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":20,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":20,"modifier":"EXACT"}},"description":"Polar residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]}],"keywords":[{"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"id":"KW-1133","category":"Domain","name":"Transmembrane helix"}],"references":[{"referenceNumber":1,"citation":{"id":"1997423","citationType":"journal article","authors":["de la Maza L.M.","Fiedler T.J.","Carlson E.J.","Markoff B.A.","Peterson E.M."],"citationCrossReferences":[{"database":"PubMed","id":"1997423"},{"database":"DOI","id":"10.1128/iai.59.3.1196-1201.1991"}],"title":"Sequence diversity of the 60-kilodalton protein and of a putative 15-kilodalton protein between the trachoma and lymphogranuloma venereum biovars of Chlamydia trachomatis.","publicationDate":"1991","journal":"Infect. Immun.","firstPage":"1196","lastPage":"1201","volume":"59"},"referencePositions":["NUCLEOTIDE SEQUENCE [GENOMIC DNA]"],"referenceComments":[{"value":"BOUR / Serovar E","type":"STRAIN"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"X54389","properties":[{"key":"ProteinId","value":"CAA38260.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"PIR","id":"E43584","properties":[{"key":"EntryName","value":"E43584"}]},{"database":"RefSeq","id":"WP_009873135.1","properties":[{"key":"NucleotideSequenceId","value":"NC_022106.1"}]},{"database":"AlphaFoldDB","id":"P26757","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"AFQITMI","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"GO","id":"GO:0019867","properties":[{"key":"GoTerm","value":"C:outer membrane"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"InterPro","id":"IPR008436","properties":[{"key":"EntryName","value":"SRP-like"}]},{"database":"Pfam","id":"PF05745","properties":[{"key":"EntryName","value":"CRPA"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MSTVPVVQGAGSSNSAQDISTSSAPLTLKERISNLLSSTAFKVGLVVIGLLLVITALIFLVSAASFVNAIYLGIPAILGCVNICVGILSIEGHCSPERWILCKKVLKTSEDIIDDGQINNSNKVFTDERLNAMDGVVESLSRRNSLVDQTQ","length":151,"molWeight":16020,"crc64":"C6CA7DFB8FC0C354","md5":"746DC00C09C5534148E6D7EFAEA384E9"},"extraAttributes":{"countByCommentType":{"SUBCELLULAR LOCATION":1},"countByFeatureType":{"Chain":1,"Transmembrane":2,"Region":1,"Compositional bias":1},"uniParcId":"UPI0000128472"}},{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"P0CE18","secondaryAccessions":["P08783","P08784","P10557","Q46431"],"uniProtkbId":"GP3D_CHLTH","entryAudit":{"firstPublicDate":"2010-03-02","lastAnnotationUpdateDate":"2026-11-04","lastSequenceUpdateDate":"2010-03-02","entryVersion":54,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Chlamydia trachomatis","taxonId":813,"lineage":["Bacteria","Pseudomonadati","Chlamydiota","Chlamydiia","Chlamydiales","Chlamydiaceae","Chlamydia/Chlamydophila group","Chlamydia"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"value":"Virulence plasmid protein pGP3-D"}},"alternativeNames":[{"fullName":{"value":"Proteins P-6/P-7"}}]},"comments":[{"texts":[{"value":"PGP3-D is required for growth within mammalian cells"}],"commentType":"MISCELLANEOUS"},{"commentType":"SEQUENCE CAUTION","sequenceCautionType":"Frameshift","sequence":"AAB02589.1","evidences":[{"evidenceCode":"ECO:0000305"}]}],"features":[{"type":"Initiator methionine","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":1,"modifier":"EXACT"}},"description":"Removed","evidences":[{"evidenceCode":"ECO:0000250"}]},{"type":"Chain","location":{"start":{"value":2,"modifier":"EXACT"},"end":{"value":264,"modifier":"EXACT"}},"description":"Virulence plasmid protein pGP3-D","featureId":"PRO_0000218344"},{"type":"Natural variant","location":{"start":{"value":12,"modifier":"EXACT"},"end":{"value":12,"modifier":"EXACT"}},"description":"in plasmid PCHL1 and plasmid pCTT1","featureId":"","alternativeSequence":{"originalSequence":"Q","alternativeSequences":["E"]}},{"type":"Natural variant","location":{"start":{"value":61,"modifier":"EXACT"},"end":{"value":61,"modifier":"EXACT"}},"description":"in plasmid PCHL1 and plasmid pCTT1","featureId":"","alternativeSequence":{"originalSequence":"P","alternativeSequences":["S"]}},{"type":"Natural variant","location":{"start":{"value":86,"modifier":"EXACT"},"end":{"value":86,"modifier":"EXACT"}},"description":"in plasmid pCTT1","featureId":"","alternativeSequence":{"originalSequence":"D","alternativeSequences":["N"]}},{"type":"Natural variant","location":{"start":{"value":90,"modifier":"EXACT"},"end":{"value":90,"modifier":"EXACT"}},"description":"in plasmid pCHL1 and plasmid pCTT1","featureId":"","alternativeSequence":{"originalSequence":"G","alternativeSequences":["D"]}},{"type":"Natural variant","location":{"start":{"value":109,"modifier":"EXACT"},"end":{"value":109,"modifier":"EXACT"}},"description":"in plasmid pCHL1","featureId":"","alternativeSequence":{"originalSequence":"T","alternativeSequences":["K"]}},{"type":"Natural variant","location":{"start":{"value":138,"modifier":"EXACT"},"end":{"value":138,"modifier":"EXACT"}},"description":"in plasmid pCHL1 and plasmid pCTT1","featureId":"","alternativeSequence":{"originalSequence":"R","alternativeSequences":["S"]}},{"type":"Natural variant","location":{"start":{"value":189,"modifier":"EXACT"},"end":{"value":189,"modifier":"EXACT"}},"description":"in plasmid pCTT1","featureId":"","alternativeSequence":{"originalSequence":"K","alternativeSequences":["N"]}},{"type":"Natural variant","location":{"start":{"value":191,"modifier":"EXACT"},"end":{"value":191,"modifier":"EXACT"}},"description":"in plasmid pCHL1 and plasmid pCTT1","featureId":"","alternativeSequence":{"originalSequence":"Y","alternativeSequences":["C"]}},{"type":"Natural variant","location":{"start":{"value":201,"modifier":"EXACT"},"end":{"value":201,"modifier":"EXACT"}},"description":"in plasmid pCHL1","featureId":"","alternativeSequence":{"originalSequence":"V","alternativeSequences":["I"]}},{"type":"Natural variant","location":{"start":{"value":210,"modifier":"EXACT"},"end":{"value":210,"modifier":"EXACT"}},"description":"in plasmid pCHL1 and plasmid pCTT1","featureId":"","alternativeSequence":{"originalSequence":"R","alternativeSequences":["S"]}},{"type":"Natural variant","location":{"start":{"value":212,"modifier":"EXACT"},"end":{"value":212,"modifier":"EXACT"}},"description":"in plasmid pCHL1 and plasmid pCTT1","featureId":"","alternativeSequence":{"originalSequence":"I","alternativeSequences":["T"]}},{"type":"Beta strand","location":{"start":{"value":5,"modifier":"EXACT"},"end":{"value":9,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6GJT"}]},{"type":"Beta strand","location":{"start":{"value":12,"modifier":"EXACT"},"end":{"value":16,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6GJT"}]},{"type":"Helix","location":{"start":{"value":101,"modifier":"EXACT"},"end":{"value":108,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6GJT"}]},{"type":"Beta strand","location":{"start":{"value":120,"modifier":"EXACT"},"end":{"value":125,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6GJT"}]},{"type":"Beta strand","location":{"start":{"value":129,"modifier":"EXACT"},"end":{"value":131,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6GJT"}]},{"type":"Turn","location":{"start":{"value":137,"modifier":"EXACT"},"end":{"value":141,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6GJT"}]},{"type":"Beta strand","location":{"start":{"value":145,"modifier":"EXACT"},"end":{"value":154,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6GJT"}]},{"type":"Beta strand","location":{"start":{"value":162,"modifier":"EXACT"},"end":{"value":172,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6GJT"}]},{"type":"Beta strand","location":{"start":{"value":174,"modifier":"EXACT"},"end":{"value":184,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6GJT"}]},{"type":"Beta strand","location":{"start":{"value":191,"modifier":"EXACT"},"end":{"value":201,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6GJT"}]},{"type":"Beta strand","location":{"start":{"value":203,"modifier":"EXACT"},"end":{"value":212,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6GJT"}]},{"type":"Beta strand","location":{"start":{"value":215,"modifier":"EXACT"},"end":{"value":217,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6GJT"}]},{"type":"Beta strand","location":{"start":{"value":219,"modifier":"EXACT"},"end":{"value":230,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6GJT"}]},{"type":"Beta strand","location":{"start":{"value":233,"modifier":"EXACT"},"end":{"value":237,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6GJT"}]},{"type":"Helix","location":{"start":{"value":244,"modifier":"EXACT"},"end":{"value":246,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6GJT"}]},{"type":"Beta strand","location":{"start":{"value":251,"modifier":"EXACT"},"end":{"value":258,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6GJT"}]}],"geneLocations":[{"value":"pLGV440","geneEncodingType":"Plasmid"},{"value":"pCHL1","geneEncodingType":"Plasmid"},{"value":"pCTT1","geneEncodingType":"Plasmid"}],"keywords":[{"id":"KW-0002","category":"Technical term","name":"3D-structure"},{"id":"KW-0614","category":"Technical term","name":"Plasmid"}],"references":[{"referenceNumber":1,"citation":{"id":"2836808","citationType":"journal article","authors":["Hatt C.","Ward M.E.","Clarke I.N."],"citationCrossReferences":[{"database":"PubMed","id":"2836808"},{"database":"DOI","id":"10.1093/nar/16.9.4053"}],"title":"Analysis of the entire nucleotide sequence of the cryptic plasmid of Chlamydia trachomatis serovar L1. Evidence for involvement in DNA replication.","publicationDate":"1988","journal":"Nucleic Acids Res.","firstPage":"4053","lastPage":"4067","volume":"16"},"referencePositions":["NUCLEOTIDE SEQUENCE [GENOMIC DNA]"],"referenceComments":[{"value":"L1/440/LN","type":"STRAIN"},{"value":"pLGV440","type":"PLASMID"}]},{"referenceNumber":2,"citation":{"id":"2194229","citationType":"journal article","authors":["Comanducci M.","Ricci S.","Cevenini R.","Ratti G."],"citationCrossReferences":[{"database":"PubMed","id":"2194229"},{"database":"DOI","id":"10.1016/0147-619x(90)90034-a"}],"title":"Diversity of the Chlamydia trachomatis common plasmid in biovars with different pathogenicity.","publicationDate":"1990","journal":"Plasmid","firstPage":"149","lastPage":"154","volume":"23"},"referencePositions":["NUCLEOTIDE SEQUENCE [GENOMIC DNA]"],"referenceComments":[{"value":"D/GO/86","type":"STRAIN"},{"value":"pCHL1","type":"PLASMID"}]},{"referenceNumber":3,"citation":{"id":"3444859","citationType":"journal article","authors":["Sriprakash K.S.","Macavoy E.S."],"citationCrossReferences":[{"database":"PubMed","id":"3444859"},{"database":"DOI","id":"10.1016/0147-619x(87)90063-1"}],"title":"Characterization and sequence of a plasmid from the trachoma biovar of Chlamydia trachomatis.","publicationDate":"1987","journal":"Plasmid","firstPage":"205","lastPage":"214","volume":"18"},"referencePositions":["NUCLEOTIDE SEQUENCE [GENOMIC DNA]"],"referenceComments":[{"value":"Serotype B","type":"STRAIN"},{"value":"pCTT1","type":"PLASMID"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"X06707","properties":[{"key":"ProteinId","value":"CAA29894.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"J03321","properties":[{"key":"ProteinId","value":"AAA91571.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"M19487","properties":[{"key":"ProteinId","value":"AAB02589.1"},{"key":"Status","value":"ALT_FRAME"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"PIR","id":"S01922","properties":[{"key":"EntryName","value":"S01922"}]},{"database":"RefSeq","id":"WP_012209816.1","properties":[{"key":"NucleotideSequenceId","value":"NC_010286.1"}]},{"database":"PDB","id":"6GJT","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.98 A"},{"key":"Chains","value":"A/B/C/D/E/F=1-264"}]},{"database":"AlphaFoldDB","id":"P0CE18","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"P0CE18","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"AFKNFPI","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"PHI-base","id":"PHI:10674","properties":[{"key":"Description","value":"-"}]},{"database":"PHI-base","id":"PHI:4562","properties":[{"key":"Description","value":"-"}]},{"database":"DisProt","id":"DP03606","properties":[{"key":"Description","value":"-"}]},{"database":"Gene3D","id":"2.60.120.1340","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"6.10.250.3190","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"6.20.30.20","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR008444","properties":[{"key":"EntryName","value":"Chlamydia_pGP3"}]},{"database":"InterPro","id":"IPR049000","properties":[{"key":"EntryName","value":"PGP3-D_N"}]},{"database":"InterPro","id":"IPR033758","properties":[{"key":"EntryName","value":"pGP3_C"}]},{"database":"Pfam","id":"PF05475","properties":[{"key":"EntryName","value":"Chlam_vir"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF20857","properties":[{"key":"EntryName","value":"Pgp3_helical"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF20858","properties":[{"key":"EntryName","value":"Pgp3_N"},{"key":"MatchStatus","value":"1"}]},{"database":"PIRSF","id":"PIRSF016070","properties":[{"key":"EntryName","value":"Chlamydia_vir"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MGNSGFYLYNTQNCVFADNIKVGQMTEPLKDQQIILGTTSTPVAAKMTASDGISLTVSNNPSTNASITIGLDAEKAYQLILEKLGDQILGGIADTIVDSTVQDILDKITTDPSLGLLKAFNNFPITNKIQCNGLFTPRNIETLLGGTEIGKFTVTPKSSGSMFLVSADIIASRMEGGVVLALVREGDSKPYAISYGYSSGVPNLCSLRTRIINTGLTPTTYSLRVGGLESGVVWVNALSNGNDILGITNTSNVSFLEVIPQTNA","length":264,"molWeight":27923,"crc64":"CE62244839F8971B","md5":"417A00283417EBC1C021685590CD2F99"},"extraAttributes":{"countByCommentType":{"MISCELLANEOUS":1,"SEQUENCE CAUTION":1},"countByFeatureType":{"Initiator methionine":1,"Chain":1,"Natural variant":11,"Beta strand":13,"Helix":2,"Turn":1},"uniParcId":"UPI000002C7DE"}},{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"P0DJI1","secondaryAccessions":["P18585","P21356"],"uniProtkbId":"OMCA_CHLTH","entryAudit":{"firstPublicDate":"2012-06-13","lastAnnotationUpdateDate":"2026-11-04","lastSequenceUpdateDate":"2012-06-13","entryVersion":30,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Chlamydia trachomatis","taxonId":813,"lineage":["Bacteria","Pseudomonadati","Chlamydiota","Chlamydiia","Chlamydiales","Chlamydiaceae","Chlamydia/Chlamydophila group","Chlamydia"]},"proteinExistence":"2: Evidence at transcript level","proteinDescription":{"recommendedName":{"fullName":{"value":"Small cysteine-rich outer membrane protein OmcA"},"shortNames":[{"value":"Small-CRP"}]},"alternativeNames":[{"fullName":{"value":"9 kDa cysteine-rich lipoprotein"},"shortNames":[{"value":"9kDa-CRP"}]}],"flag":"Precursor"},"genes":[{"geneName":{"value":"omcA"},"synonyms":[{"value":"omp3"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250"}],"value":"In elementary bodies (EBs, the infectious stage, which is able to survive outside the host cell) provides the structural integrity of the outer envelope through disulfide cross-links with the large cysteine-rich periplasmic protein and the major outer membrane porin. It has been described in publications as the Sarkosyl-insoluble COMC (Chlamydia outer membrane complex), and serves as the functional equivalent of peptidoglycan (By similarity)"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250"}],"value":"Part of a disulfide cross-linked outer membrane complex (COMC) composed of the major outer membrane porin (MOMP), the small cysteine-rich protein (OmcA) and the large cysteine-rich periplasmic protein (OmcB)"}],"commentType":"SUBUNIT"},{"commentType":"SUBCELLULAR LOCATION","note":{"texts":[{"value":"The protein moiety probably penetrates into the periplasm"}]},"subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Cell outer membrane","id":"SL-0040"},"topology":{"evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00303"}],"value":"Lipid-anchor","id":"SL-9901"}}]},{"texts":[{"value":"It is present but the disulfide bonds are reduced in reticulate bodies (RBs)"}],"commentType":"DEVELOPMENTAL STAGE"}],"features":[{"type":"Signal","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":18,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00303"}]},{"type":"Chain","location":{"start":{"value":19,"modifier":"EXACT"},"end":{"value":88,"modifier":"EXACT"}},"description":"Small cysteine-rich outer membrane protein OmcA","featureId":"PRO_0000018156"},{"type":"Region","location":{"start":{"value":67,"modifier":"EXACT"},"end":{"value":88,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":67,"modifier":"EXACT"},"end":{"value":88,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Lipidation","location":{"start":{"value":19,"modifier":"EXACT"},"end":{"value":19,"modifier":"EXACT"}},"description":"N-palmitoyl cysteine","evidences":[{"evidenceCode":"ECO:0000305"}]},{"type":"Lipidation","location":{"start":{"value":19,"modifier":"EXACT"},"end":{"value":19,"modifier":"EXACT"}},"description":"S-diacylglycerol cysteine","evidences":[{"evidenceCode":"ECO:0000305"}]}],"keywords":[{"id":"KW-0998","category":"Cellular component","name":"Cell outer membrane"},{"id":"KW-0133","category":"Biological process","name":"Cell shape"},{"id":"KW-1015","category":"PTM","name":"Disulfide bond"},{"id":"KW-0449","category":"PTM","name":"Lipoprotein"},{"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"id":"KW-0564","category":"PTM","name":"Palmitate"},{"id":"KW-0732","category":"Domain","name":"Signal"}],"references":[{"referenceNumber":1,"citation":{"id":"2332164","citationType":"journal article","authors":["Lambden P.R.","Everson J.S.","Ward M.E.","Clarke I.N."],"citationCrossReferences":[{"database":"PubMed","id":"2332164"},{"database":"DOI","id":"10.1016/0378-1119(90)90500-q"}],"title":"Sulfur-rich proteins of Chlamydia trachomatis: developmentally regulated transcription of polycistronic mRNA from tandem promoters.","publicationDate":"1990","journal":"Gene","firstPage":"105","lastPage":"112","volume":"87"},"referencePositions":["NUCLEOTIDE SEQUENCE [GENOMIC DNA]"],"referenceComments":[{"value":"L1/440/LN","type":"STRAIN"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"M35148","properties":[{"key":"ProteinId","value":"AAA23118.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"PIR","id":"JQ0514","properties":[{"key":"EntryName","value":"JQ0514"}]},{"database":"RefSeq","id":"WP_009873814.1","properties":[{"key":"NucleotideSequenceId","value":"NZ_CAAKND010000006.1"}]},{"database":"AlphaFoldDB","id":"P0DJI1","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"APKPCNP","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"GO","id":"GO:0009279","properties":[{"key":"GoTerm","value":"C:cell outer membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0005201","properties":[{"key":"GoTerm","value":"F:extracellular matrix structural constituent"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"InterPro","id":"IPR003517","properties":[{"key":"EntryName","value":"Cys-rich_OMP3_Chlamydia"}]},{"database":"Pfam","id":"PF03503","properties":[{"key":"EntryName","value":"Chlam_OMP3"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR01335","properties":[{"key":"EntryName","value":"CHLAMIDIAOM3"}]},{"database":"PROSITE","id":"PS51257","properties":[{"key":"EntryName","value":"PROKAR_LIPOPROTEIN"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MKKTALLAALCSVVSLSSCCRIVDCCFEDPCAPIQCSPCESKKKDVDGGCNSCNGYVPACKPCGGDTHQDAEHGPQAREIPVDGKCRQ","length":88,"molWeight":9279,"crc64":"D35B0584EEC7DA1B","md5":"505E0E76263AAC6680861DD99A572819"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"SUBUNIT":1,"SUBCELLULAR LOCATION":1,"DEVELOPMENTAL STAGE":1},"countByFeatureType":{"Signal":1,"Chain":1,"Region":1,"Compositional bias":1,"Lipidation":2},"uniParcId":"UPI0000130CB6"}},{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"Q06281","uniProtkbId":"HC2B_CHLTH","entryAudit":{"firstPublicDate":"2000-05-30","lastAnnotationUpdateDate":"2026-11-04","lastSequenceUpdateDate":"1996-11-01","entryVersion":50,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Chlamydia trachomatis","taxonId":813,"lineage":["Bacteria","Pseudomonadati","Chlamydiota","Chlamydiia","Chlamydiales","Chlamydiaceae","Chlamydia/Chlamydophila group","Chlamydia"]},"proteinExistence":"2: Evidence at transcript level","proteinDescription":{"recommendedName":{"fullName":{"value":"Histone H1-like protein HC2"}},"alternativeNames":[{"fullName":{"value":"HC2 nucleoprotein"}}]},"genes":[{"geneName":{"value":"hctB"}}],"comments":[{"texts":[{"value":"Might have a role in establishing the nucleoid structure of elementary bodies"}],"commentType":"FUNCTION"},{"texts":[{"value":"Specific to the EB (elementary body) form in the life cycle of chlamydiae"}],"commentType":"DEVELOPMENTAL STAGE"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Belongs to the histone H1/H5 family. HCT subfamily"}],"commentType":"SIMILARITY"}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":165,"modifier":"EXACT"}},"description":"Histone H1-like protein HC2","featureId":"PRO_0000196022"},{"type":"Region","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":80,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":50,"modifier":"EXACT"}},"description":"Basic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":59,"modifier":"EXACT"},"end":{"value":80,"modifier":"EXACT"}},"description":"Basic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]}],"keywords":[{"id":"KW-0238","category":"Molecular function","name":"DNA-binding"},{"id":"KW-0677","category":"Domain","name":"Repeat"}],"references":[{"referenceNumber":1,"citation":{"id":"8406036","citationType":"journal article","authors":["Hackstadt T.","Brickman T.J.","Barry C.E. III","Sager J."],"citationCrossReferences":[{"database":"PubMed","id":"8406036"},{"database":"DOI","id":"10.1016/0378-1119(93)90526-9"}],"title":"Diversity in the Chlamydia trachomatis histone homologue Hc2.","publicationDate":"1993","journal":"Gene","firstPage":"137","lastPage":"141","volume":"132"},"referencePositions":["NUCLEOTIDE SEQUENCE [GENOMIC DNA]"],"referenceComments":[{"value":"B/Tw-5/OT","type":"STRAIN"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"L12962","properties":[{"key":"ProteinId","value":"AAA03752.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Unassigned_DNA"}]},{"database":"PIR","id":"JN0853","properties":[{"key":"EntryName","value":"JN0853"}]},{"database":"AlphaFoldDB","id":"Q06281","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"ADRGGHC","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"GO","id":"GO:0003677","properties":[{"key":"GoTerm","value":"F:DNA binding"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0030527","properties":[{"key":"GoTerm","value":"F:structural constituent of chromatin"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0030261","properties":[{"key":"GoTerm","value":"P:chromosome condensation"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"InterPro","id":"IPR009970","properties":[{"key":"EntryName","value":"HC2"}]},{"database":"NCBIfam","id":"NF038052","properties":[{"key":"EntryName","value":"histone_lik_HC2"},{"key":"MatchStatus","value":"2"}]},{"database":"Pfam","id":"PF07382","properties":[{"key":"EntryName","value":"HC2"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MLGVQKKRSTRKTAARKTVVRKPAAKKTAAKKAPVRKVAAKKTVARKTVAKKTVAARKPVAKKATAKKAPVRKVAAKKTVARKTVAKKTVAARKPVAKRVASTKKSSVAVKAGVCMKKHKHTAACGRVAASGVKVCASAAKRKTNPNRSRTAHSWRQQLMKLVAR","length":165,"molWeight":17660,"crc64":"CF4179C61A4D0C05","md5":"CFEE8533A3929B9EBCBC374838FF46F4"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"DEVELOPMENTAL STAGE":1,"SIMILARITY":1},"countByFeatureType":{"Chain":1,"Region":1,"Compositional bias":2},"uniParcId":"UPI000012C32E"}}]}