{"results":[{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0A4Y5SIP5","uniProtkbId":"A0A4Y5SIP5_9AGAM","entryAudit":{"firstPublicDate":"2019-09-18","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2019-09-18","entryVersion":19,"sequenceVersion":1},"annotationScore":3.0,"organism":{"scientificName":"Rhizopogon vinicolor","taxonId":80600,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"QDA23239.1"}],"lineage":["Eukaryota","Fungi","Dikarya","Basidiomycota","Agaricomycotina","Agaricomycetes","Agaricomycetidae","Boletales","Suillineae","Rhizopogonaceae","Rhizopogon"]},"proteinExistence":"3: Inferred from homology","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000369"}],"value":"Cytochrome c oxidase subunit 1"},"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000369"}],"value":"7.1.1.9"}]}},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"QDA23239.1"}],"value":"cox1"}}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000369"}],"value":"Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix"}],"commentType":"FUNCTION"},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"4 Fe(II)-[cytochrome c] + O2 + 8 H(+)(in) = 4 Fe(III)-[cytochrome c] + 2 H2O + 4 H(+)(out)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:11436"},{"database":"Rhea","id":"RHEA-COMP:10350"},{"database":"Rhea","id":"RHEA-COMP:14399"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:15379"},{"database":"ChEBI","id":"CHEBI:29033"},{"database":"ChEBI","id":"CHEBI:29034"}],"ecNumber":"7.1.1.9","evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000369"}]}},{"commentType":"COFACTOR","cofactors":[{"name":"heme","evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00001971"}],"cofactorCrossReference":{"database":"ChEBI","id":"CHEBI:30413"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004673"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000369"}],"value":"Energy metabolism; oxidative phosphorylation"}],"commentType":"PATHWAY"},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004141"}],"value":"Membrane","id":"SL-0162"},"topology":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004141"}],"value":"Multi-pass membrane protein","id":"SL-9909"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000369"}],"value":"Mitochondrion inner membrane","id":"SL-0168"},"topology":{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000369"}],"value":"Multi-pass membrane protein","id":"SL-9909"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000369"}],"value":"Belongs to the heme-copper respiratory oxidase family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Transmembrane","location":{"start":{"value":12,"modifier":"EXACT"},"end":{"value":36,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":56,"modifier":"EXACT"},"end":{"value":82,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":103,"modifier":"EXACT"},"end":{"value":125,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":145,"modifier":"EXACT"},"end":{"value":170,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":182,"modifier":"EXACT"},"end":{"value":209,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":242,"modifier":"EXACT"},"end":{"value":261,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":268,"modifier":"EXACT"},"end":{"value":289,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":301,"modifier":"EXACT"},"end":{"value":324,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":336,"modifier":"EXACT"},"end":{"value":355,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":375,"modifier":"EXACT"},"end":{"value":394,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":406,"modifier":"EXACT"},"end":{"value":425,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":445,"modifier":"EXACT"},"end":{"value":471,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Domain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":527,"modifier":"EXACT"}},"description":"Cytochrome oxidase subunit I profile","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50855"}]}],"geneLocations":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"QDA23239.1"}],"geneEncodingType":"Mitochondrion"}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023008"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000369"}],"id":"KW-0186","category":"Ligand","name":"Copper"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022982"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000369"}],"id":"KW-0249","category":"Biological process","name":"Electron transport"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022617"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000369"}],"id":"KW-0349","category":"Ligand","name":"Heme"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023004"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000369"}],"id":"KW-0408","category":"Ligand","name":"Iron"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023136"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000369"}],"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022723"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000369"}],"id":"KW-0479","category":"Ligand","name":"Metal-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000369"},{"evidenceCode":"ECO:0000313","source":"EMBL","id":"QDA23239.1"}],"id":"KW-0496","category":"Cellular component","name":"Mitochondrion"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000369"}],"id":"KW-0999","category":"Cellular component","name":"Mitochondrion inner membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022660"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000369"}],"id":"KW-0679","category":"Biological process","name":"Respiratory chain"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022967"}],"id":"KW-1278","category":"Molecular function","name":"Translocase"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022692"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000369"}],"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022989"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-1133","category":"Domain","name":"Transmembrane helix"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022448"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000369"}],"id":"KW-0813","category":"Biological process","name":"Transport"}],"references":[{"referenceNumber":1,"citation":{"id":"31635252","citationType":"journal article","authors":["Li Q.","Ren Y.","Shi X.","Peng L.","Zhao J.","Song Y.","Zhao G."],"citationCrossReferences":[{"database":"PubMed","id":"31635252"}],"title":"Comparative Mitochondrial Genome Analysis of Two Ectomycorrhizal Fungi (Rhizopogon) Reveals Dynamic Changes of Intron and Phylogenetic Relationships of the Subphylum Agaricomycotina.","publicationDate":"0","journal":"Int. J. Mol. Sci.","firstPage":"0","lastPage":"0","volume":"20"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"QDA23239.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"MH794153","properties":[{"key":"ProteinId","value":"QDA23239.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"RefSeq","id":"YP_009649311.1","properties":[{"key":"NucleotideSequenceId","value":"NC_042699.1"}]},{"database":"AlphaFoldDB","id":"A0A4Y5SIP5","properties":[{"key":"Description","value":"-"}]},{"database":"GeneID","id":"40487059","properties":[{"key":"Description","value":"-"}]},{"database":"UniPathway","id":"UPA00705","properties":[{"key":"RectionId","value":"-"}]},{"database":"GO","id":"GO:0005743","properties":[{"key":"GoTerm","value":"C:mitochondrial inner membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0045277","properties":[{"key":"GoTerm","value":"C:respiratory chain complex IV"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0004129","properties":[{"key":"GoTerm","value":"F:cytochrome-c oxidase activity"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-EC"}]},{"database":"GO","id":"GO:0020037","properties":[{"key":"GoTerm","value":"F:heme binding"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0015990","properties":[{"key":"GoTerm","value":"P:electron transport coupled proton transport"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:0006123","properties":[{"key":"GoTerm","value":"P:mitochondrial electron transport, cytochrome c to oxygen"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"CDD","id":"cd01663","properties":[{"key":"EntryName","value":"Cyt_c_Oxidase_I"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.210.10:FF:000001","properties":[{"key":"EntryName","value":"Cytochrome c oxidase subunit 1"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.20.210.10","properties":[{"key":"EntryName","value":"Cytochrome c oxidase-like, subunit I domain"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR023616","properties":[{"key":"EntryName","value":"Cyt_c_oxase-like_su1_dom"}]},{"database":"InterPro","id":"IPR036927","properties":[{"key":"EntryName","value":"Cyt_c_oxase-like_su1_sf"}]},{"database":"InterPro","id":"IPR000883","properties":[{"key":"EntryName","value":"Cyt_C_Oxase_1"}]},{"database":"InterPro","id":"IPR033944","properties":[{"key":"EntryName","value":"Cyt_c_oxase_su1_dom"}]},{"database":"PANTHER","id":"PTHR10422","properties":[{"key":"EntryName","value":"CYTOCHROME C OXIDASE SUBUNIT 1"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR10422:SF18","properties":[{"key":"EntryName","value":"CYTOCHROME C OXIDASE SUBUNIT 1"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00115","properties":[{"key":"EntryName","value":"COX1"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR01165","properties":[{"key":"EntryName","value":"CYCOXIDASEI"}]},{"database":"SUPFAM","id":"SSF81442","properties":[{"key":"EntryName","value":"Cytochrome c oxidase subunit I-like"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50855","properties":[{"key":"EntryName","value":"COX1"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MNWLFSTNAKEIGTLYLIFSVFAGMIGTAFSVLIRLELAAPGVQFLQGDHQLFNVIISAHAFIMIFFMVMPGLVGGFGNYLLPVQCGAPDMAFPRLNNISFWLLPPSLILLLVSSLVENGAGTGWTVYPPLSSIQSHSGGSVDLAIFSLHLAGVSSLLGAINFITTVLNMRTNGMSLHKLPLFVWAIFVTAILLLLSLPVLAGAITMLLTDRNFNTSFYDPAGGGDPVLYQHLFYTEKHPEVYILIIPGFGIVSHIVSTFSGKPIFGYLGMVYAMFSIGILGFLVWSHHMFSVGMDVDTRAYFTAATMVIAVPTGIKIFSWLATLYGGSLRFTTPLIFTIGFLALFTIGGLTGVILSNASLDIALHDTYYVVAHFHYVLSMGAVFALFAGFYYWTPKIVGRTYNEFLGKVHFWTMFIGVNLTFFPQHFLGLAGMPRRIPDYPDAFAGWNAISSFGSLISVLATVLFGYIIFDIFANGKEVNNNPWAVPSFFTSISQFDNETDSANTLEWSLASPIPFHAFNMLPVQS","length":527,"molWeight":57795,"crc64":"EDDB9C7F082DD458","md5":"44D6DC00870EAD36434E7654ECC3F672"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"CATALYTIC ACTIVITY":1,"COFACTOR":1,"PATHWAY":1,"SUBCELLULAR LOCATION":1,"SIMILARITY":1},"countByFeatureType":{"Transmembrane":12,"Domain":1},"uniParcId":"UPI00111F6891"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0A4Y5SHU5","uniProtkbId":"A0A4Y5SHU5_9AGAM","entryAudit":{"firstPublicDate":"2019-09-18","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2019-09-18","entryVersion":13,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Rhizopogon vinicolor","taxonId":80600,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"QDA23248.1"}],"lineage":["Eukaryota","Fungi","Dikarya","Basidiomycota","Agaricomycotina","Agaricomycetes","Agaricomycetidae","Boletales","Suillineae","Rhizopogonaceae","Rhizopogon"]},"proteinExistence":"3: Inferred from homology","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU004430"}],"value":"NADH-ubiquinone oxidoreductase chain 6"},"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU004430"}],"value":"7.1.1.2"}]}},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"QDA23248.1"}],"value":"nad6"}}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU004430"}],"value":"Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I"}],"commentType":"FUNCTION"},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"a ubiquinone + NADH + 5 H(+)(in) = a ubiquinol + NAD(+) + 4 H(+)(out)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:29091"},{"database":"Rhea","id":"RHEA-COMP:9565"},{"database":"Rhea","id":"RHEA-COMP:9566"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:16389"},{"database":"ChEBI","id":"CHEBI:17976"},{"database":"ChEBI","id":"CHEBI:57540"},{"database":"ChEBI","id":"CHEBI:57945"}],"ecNumber":"7.1.1.2","evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU004430"}]}},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU004430"}],"value":"Mitochondrion membrane","id":"SL-0171"},"topology":{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU004430"}],"value":"Multi-pass membrane protein","id":"SL-9909"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU004430"}],"value":"Belongs to the complex I subunit 6 family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Transmembrane","location":{"start":{"value":6,"modifier":"EXACT"},"end":{"value":22,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU004430"}]},{"type":"Transmembrane","location":{"start":{"value":29,"modifier":"EXACT"},"end":{"value":51,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU004430"}]},{"type":"Transmembrane","location":{"start":{"value":57,"modifier":"EXACT"},"end":{"value":75,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU004430"}]},{"type":"Transmembrane","location":{"start":{"value":95,"modifier":"EXACT"},"end":{"value":115,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU004430"}]},{"type":"Transmembrane","location":{"start":{"value":172,"modifier":"EXACT"},"end":{"value":197,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU004430"}]}],"geneLocations":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"QDA23248.1"}],"geneEncodingType":"Mitochondrion"}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU004430"}],"id":"KW-0249","category":"Biological process","name":"Electron transport"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU004430"}],"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU004430"},{"evidenceCode":"ECO:0000313","source":"EMBL","id":"QDA23248.1"}],"id":"KW-0496","category":"Cellular component","name":"Mitochondrion"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU004430"}],"id":"KW-0520","category":"Ligand","name":"NAD"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU004430"}],"id":"KW-0679","category":"Biological process","name":"Respiratory chain"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU004430"}],"id":"KW-1278","category":"Molecular function","name":"Translocase"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU004430"}],"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU004430"}],"id":"KW-1133","category":"Domain","name":"Transmembrane helix"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU004430"}],"id":"KW-0813","category":"Biological process","name":"Transport"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU004430"}],"id":"KW-0830","category":"Ligand","name":"Ubiquinone"}],"references":[{"referenceNumber":1,"citation":{"id":"31635252","citationType":"journal article","authors":["Li Q.","Ren Y.","Shi X.","Peng L.","Zhao J.","Song Y.","Zhao G."],"citationCrossReferences":[{"database":"PubMed","id":"31635252"}],"title":"Comparative Mitochondrial Genome Analysis of Two Ectomycorrhizal Fungi (Rhizopogon) Reveals Dynamic Changes of Intron and Phylogenetic Relationships of the Subphylum Agaricomycotina.","publicationDate":"0","journal":"Int. J. Mol. Sci.","firstPage":"0","lastPage":"0","volume":"20"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"QDA23248.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"MH794153","properties":[{"key":"ProteinId","value":"QDA23248.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"RefSeq","id":"YP_009649333.1","properties":[{"key":"NucleotideSequenceId","value":"NC_042699.1"}]},{"database":"AlphaFoldDB","id":"A0A4Y5SHU5","properties":[{"key":"Description","value":"-"}]},{"database":"GeneID","id":"40487021","properties":[{"key":"Description","value":"-"}]},{"database":"GO","id":"GO:0031966","properties":[{"key":"GoTerm","value":"C:mitochondrial membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0008137","properties":[{"key":"GoTerm","value":"F:NADH dehydrogenase (ubiquinone) activity"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniRule"}]},{"database":"Gene3D","id":"1.20.120.1200","properties":[{"key":"EntryName","value":"NADH-ubiquinone/plastoquinone oxidoreductase chain 6, subunit NuoJ"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR001457","properties":[{"key":"EntryName","value":"NADH_UbQ/plastoQ_OxRdtase_su6"}]},{"database":"InterPro","id":"IPR042106","properties":[{"key":"EntryName","value":"Nuo/plastoQ_OxRdtase_6_NuoJ"}]},{"database":"PANTHER","id":"PTHR33269","properties":[{"key":"EntryName","value":"NADH-UBIQUINONE OXIDOREDUCTASE CHAIN 6"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR33269:SF17","properties":[{"key":"EntryName","value":"NADH-UBIQUINONE OXIDOREDUCTASE CHAIN 6"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00499","properties":[{"key":"EntryName","value":"Oxidored_q3"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MKNILINILAFGTLLSSILVITSKNPVIAVIFLISVFCNAAGYLILLGVGFIGISYILLYVGAITVLFLFVIMMINIKLTDILETGSQYTKNFPLALAIGSLFIYEIFTIMPFTFNNVSALSSLLELLTSLNNLLLNSDTSSFVNVFNTFNPNVADITITNFLHIEAIGHGLYTYGASLLIICSVILLLSMTAPIFISRKSNF","length":203,"molWeight":22194,"crc64":"55BF88DE0632F60A","md5":"55BF9808743FE7D560134F4C2ABD86B6"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"CATALYTIC ACTIVITY":1,"SUBCELLULAR LOCATION":1,"SIMILARITY":1},"countByFeatureType":{"Transmembrane":5},"uniParcId":"UPI001120C905"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0A4Y5SHW2","uniProtkbId":"A0A4Y5SHW2_9AGAM","entryAudit":{"firstPublicDate":"2019-09-18","lastAnnotationUpdateDate":"2026-11-04","lastSequenceUpdateDate":"2019-09-18","entryVersion":19,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Rhizopogon vinicolor","taxonId":80600,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"QDA23262.1"}],"lineage":["Eukaryota","Fungi","Dikarya","Basidiomycota","Agaricomycotina","Agaricomycetes","Agaricomycetidae","Boletales","Suillineae","Rhizopogonaceae","Rhizopogon"]},"proteinExistence":"3: Inferred from homology","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00016612"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU004419"}],"value":"NADH-ubiquinone oxidoreductase chain 4L"},"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00012944"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU004419"}],"value":"7.1.1.2"}]}},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"QDA23262.1"}],"value":"nad4L"}}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU004419"}],"value":"Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor"}],"commentType":"FUNCTION"},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"a ubiquinone + NADH + 5 H(+)(in) = a ubiquinol + NAD(+) + 4 H(+)(out)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:29091"},{"database":"Rhea","id":"RHEA-COMP:9565"},{"database":"Rhea","id":"RHEA-COMP:9566"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:16389"},{"database":"ChEBI","id":"CHEBI:17976"},{"database":"ChEBI","id":"CHEBI:57540"},{"database":"ChEBI","id":"CHEBI:57945"}],"ecNumber":"7.1.1.2","evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00049551"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU004419"}]}},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU004419"}],"value":"Mitochondrion inner membrane","id":"SL-0168"},"topology":{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU004419"}],"value":"Multi-pass membrane protein","id":"SL-9909"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004225"}],"value":"Mitochondrion membrane","id":"SL-0171"},"topology":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004225"}],"value":"Multi-pass membrane protein","id":"SL-9909"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00010519"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU004419"}],"value":"Belongs to the complex I subunit 4L family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Transmembrane","location":{"start":{"value":21,"modifier":"EXACT"},"end":{"value":43,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU004419"}]},{"type":"Transmembrane","location":{"start":{"value":55,"modifier":"EXACT"},"end":{"value":78,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU004419"}]}],"geneLocations":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"QDA23262.1"}],"geneEncodingType":"Mitochondrion"}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU004419"}],"id":"KW-0249","category":"Biological process","name":"Electron transport"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023136"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU004419"}],"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023128"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU004419"}],"id":"KW-0496","category":"Cellular component","name":"Mitochondrion"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU004419"}],"id":"KW-0999","category":"Cellular component","name":"Mitochondrion inner membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023027"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU004419"}],"id":"KW-0520","category":"Ligand","name":"NAD"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022660"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU004419"}],"id":"KW-0679","category":"Biological process","name":"Respiratory chain"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU004419"}],"id":"KW-1278","category":"Molecular function","name":"Translocase"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022692"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU004419"}],"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022989"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU004419"}],"id":"KW-1133","category":"Domain","name":"Transmembrane helix"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022448"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU004419"}],"id":"KW-0813","category":"Biological process","name":"Transport"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU004419"}],"id":"KW-0830","category":"Ligand","name":"Ubiquinone"}],"references":[{"referenceNumber":1,"citation":{"id":"31635252","citationType":"journal article","authors":["Li Q.","Ren Y.","Shi X.","Peng L.","Zhao J.","Song Y.","Zhao G."],"citationCrossReferences":[{"database":"PubMed","id":"31635252"}],"title":"Comparative Mitochondrial Genome Analysis of Two Ectomycorrhizal Fungi (Rhizopogon) Reveals Dynamic Changes of Intron and Phylogenetic Relationships of the Subphylum Agaricomycotina.","publicationDate":"0","journal":"Int. J. Mol. Sci.","firstPage":"0","lastPage":"0","volume":"20"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"QDA23262.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"MH794153","properties":[{"key":"ProteinId","value":"QDA23262.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"RefSeq","id":"YP_009649347.1","properties":[{"key":"NucleotideSequenceId","value":"NC_042699.1"}]},{"database":"AlphaFoldDB","id":"A0A4Y5SHW2","properties":[{"key":"Description","value":"-"}]},{"database":"GeneID","id":"40487048","properties":[{"key":"Description","value":"-"}]},{"database":"GO","id":"GO:0005743","properties":[{"key":"GoTerm","value":"C:mitochondrial inner membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0030964","properties":[{"key":"GoTerm","value":"C:NADH dehydrogenase complex"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:0008137","properties":[{"key":"GoTerm","value":"F:NADH dehydrogenase (ubiquinone) activity"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-EC"}]},{"database":"GO","id":"GO:0042773","properties":[{"key":"GoTerm","value":"P:ATP synthesis coupled electron transport"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniRule"}]},{"database":"FunFam","id":"1.10.287.3510:FF:000004","properties":[{"key":"EntryName","value":"NADH-ubiquinone oxidoreductase chain 4L"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.10.287.3510","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR001133","properties":[{"key":"EntryName","value":"NADH_UbQ_OxRdtase_chain4L/K"}]},{"database":"InterPro","id":"IPR039428","properties":[{"key":"EntryName","value":"NUOK/Mnh_C1-like"}]},{"database":"NCBIfam","id":"NF004320","properties":[{"key":"EntryName","value":"nuoK"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR11434:SF16","properties":[{"key":"EntryName","value":"NADH-UBIQUINONE OXIDOREDUCTASE CHAIN 4L"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR11434","properties":[{"key":"EntryName","value":"NADH-UBIQUINONE OXIDOREDUCTASE SUBUNIT ND4L"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00420","properties":[{"key":"EntryName","value":"Oxidored_q2"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MNLSLFLFLIGILGFILNRKNIILMIIAIEIMLLAVTLLILISSFSFDDNVGQTFSIYIISIAGAESVIGLSILVAFYRLRGNISIRT","length":88,"molWeight":9737,"crc64":"D754C73ED636914C","md5":"C12844139A52C1357B2349CDA3D3DC66"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"CATALYTIC ACTIVITY":1,"SUBCELLULAR LOCATION":1,"SIMILARITY":1},"countByFeatureType":{"Transmembrane":2},"uniParcId":"UPI00111EE8FC"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0A4Y5SI41","uniProtkbId":"A0A4Y5SI41_9AGAM","entryAudit":{"firstPublicDate":"2019-09-18","lastAnnotationUpdateDate":"2026-11-04","lastSequenceUpdateDate":"2019-09-18","entryVersion":22,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Rhizopogon vinicolor","taxonId":80600,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"QDA23240.1"}],"lineage":["Eukaryota","Fungi","Dikarya","Basidiomycota","Agaricomycotina","Agaricomycetes","Agaricomycetidae","Boletales","Suillineae","Rhizopogonaceae","Rhizopogon"]},"proteinExistence":"3: Inferred from homology","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00021312"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU004450"}],"value":"ATP synthase subunit a"}}},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"QDA23240.1"}],"value":"atp6"}}],"comments":[{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004448"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU004450"}],"value":"Mitochondrion inner membrane","id":"SL-0168"},"topology":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004448"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU004450"}],"value":"Multi-pass membrane protein","id":"SL-9909"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00006810"}],"value":"Belongs to the ATPase A chain family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Transmembrane","location":{"start":{"value":31,"modifier":"EXACT"},"end":{"value":56,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":94,"modifier":"EXACT"},"end":{"value":113,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":119,"modifier":"EXACT"},"end":{"value":144,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":177,"modifier":"EXACT"},"end":{"value":198,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":205,"modifier":"EXACT"},"end":{"value":228,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]}],"geneLocations":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"QDA23240.1"}],"geneEncodingType":"Mitochondrion"}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023310"}],"id":"KW-0066","category":"Biological process","name":"ATP synthesis"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022547"}],"id":"KW-0138","category":"Cellular component","name":"CF(0)"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022781"}],"id":"KW-0375","category":"Biological process","name":"Hydrogen ion transport"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023065"}],"id":"KW-0406","category":"Biological process","name":"Ion transport"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023136"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"QDA23240.1"}],"id":"KW-0496","category":"Cellular component","name":"Mitochondrion"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022692"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022989"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-1133","category":"Domain","name":"Transmembrane helix"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022448"}],"id":"KW-0813","category":"Biological process","name":"Transport"}],"references":[{"referenceNumber":1,"citation":{"id":"31635252","citationType":"journal article","authors":["Li Q.","Ren Y.","Shi X.","Peng L.","Zhao J.","Song Y.","Zhao G."],"citationCrossReferences":[{"database":"PubMed","id":"31635252"}],"title":"Comparative Mitochondrial Genome Analysis of Two Ectomycorrhizal Fungi (Rhizopogon) Reveals Dynamic Changes of Intron and Phylogenetic Relationships of the Subphylum Agaricomycotina.","publicationDate":"0","journal":"Int. J. Mol. Sci.","firstPage":"0","lastPage":"0","volume":"20"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"QDA23240.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"MH794153","properties":[{"key":"ProteinId","value":"QDA23240.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"RefSeq","id":"YP_009649325.1","properties":[{"key":"NucleotideSequenceId","value":"NC_042699.1"}]},{"database":"AlphaFoldDB","id":"A0A4Y5SI41","properties":[{"key":"Description","value":"-"}]},{"database":"GeneID","id":"40487004","properties":[{"key":"Description","value":"-"}]},{"database":"GO","id":"GO:0005743","properties":[{"key":"GoTerm","value":"C:mitochondrial inner membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0045259","properties":[{"key":"GoTerm","value":"C:proton-transporting ATP synthase complex"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0046933","properties":[{"key":"GoTerm","value":"F:proton-transporting ATP synthase activity, rotational mechanism"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"CDD","id":"cd00310","properties":[{"key":"EntryName","value":"ATP-synt_Fo_a_6"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.120.220:FF:000003","properties":[{"key":"EntryName","value":"ATP synthase subunit a"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.20.120.220","properties":[{"key":"EntryName","value":"ATP synthase, F0 complex, subunit A"},{"key":"MatchStatus","value":"1"}]},{"database":"HAMAP","id":"MF_01393","properties":[{"key":"EntryName","value":"ATP_synth_a_bact"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR000568","properties":[{"key":"EntryName","value":"ATP_synth_F0_asu"}]},{"database":"InterPro","id":"IPR023011","properties":[{"key":"EntryName","value":"ATP_synth_F0_asu_AS"}]},{"database":"InterPro","id":"IPR045083","properties":[{"key":"EntryName","value":"ATP_synth_F0_asu_bact/mt"}]},{"database":"InterPro","id":"IPR035908","properties":[{"key":"EntryName","value":"F0_ATP_A_sf"}]},{"database":"NCBIfam","id":"TIGR01131","properties":[{"key":"EntryName","value":"ATP_synt_6_or_A"},{"key":"MatchStatus","value":"1"}]},{"database":"NCBIfam","id":"NF004482","properties":[{"key":"EntryName","value":"PRK05815.2-4"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR11410","properties":[{"key":"EntryName","value":"ATP SYNTHASE SUBUNIT A"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR11410:SF0","properties":[{"key":"EntryName","value":"ATP SYNTHASE SUBUNIT A"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00119","properties":[{"key":"EntryName","value":"ATP-synt_A"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR00123","properties":[{"key":"EntryName","value":"ATPASEA"}]},{"database":"SUPFAM","id":"SSF81336","properties":[{"key":"EntryName","value":"F1F0 ATP synthase subunit A"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00449","properties":[{"key":"EntryName","value":"ATPASE_A"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MLMNIIQSNLYINSPLEQFEVTSLLSLDAPILGYIGLTLTNLALYSFLIFILIVGLHFMGNNDTKLLPSKWSILLESLFASINSMVREQIGREIYLPFIYSLFFFILIANLLGNIPYSYTITTSVIVSIGLSFTILIGVTILGLSIHKIHFFSFFIPSGTPLALVPLLVLIELISYLARAFSLGIRLFANVVAGHTLLKILSTFLYQMFSGGLIIFIVTLVPFALFLAITGLELAVSFIQAYVFVLLVCSYIKDAIELH","length":259,"molWeight":28803,"crc64":"1E416C2A31ABE9F3","md5":"921C023D1DF722342F7499D9DC491985"},"extraAttributes":{"countByCommentType":{"SUBCELLULAR LOCATION":1,"SIMILARITY":1},"countByFeatureType":{"Transmembrane":5},"uniParcId":"UPI0011205C3A"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0A4Y5SI48","uniProtkbId":"A0A4Y5SI48_9AGAM","entryAudit":{"firstPublicDate":"2019-09-18","lastAnnotationUpdateDate":"2026-11-04","lastSequenceUpdateDate":"2019-09-18","entryVersion":23,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Rhizopogon vinicolor","taxonId":80600,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"QDA23250.1"}],"lineage":["Eukaryota","Fungi","Dikarya","Basidiomycota","Agaricomycotina","Agaricomycetes","Agaricomycetidae","Boletales","Suillineae","Rhizopogonaceae","Rhizopogon"]},"proteinExistence":"3: Inferred from homology","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU368038"}],"value":"ATP synthase protein 8"}}},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"QDA23250.1"}],"value":"atp8"}}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU368038"}],"value":"Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. Minor subunit located with subunit a in the membrane"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU368038"}],"value":"F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel"}],"commentType":"SUBUNIT"},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004167"}],"value":"Membrane","id":"SL-0162"},"topology":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004167"}],"value":"Single-pass membrane protein","id":"SL-9904"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU368038"}],"value":"Mitochondrion inner membrane","id":"SL-0168"},"topology":{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU368038"}],"value":"Single-pass membrane protein","id":"SL-9904"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00008892"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU368038"}],"value":"Belongs to the ATPase protein 8 family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Transmembrane","location":{"start":{"value":12,"modifier":"EXACT"},"end":{"value":32,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU368038"}]}],"geneLocations":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"QDA23250.1"}],"geneEncodingType":"Mitochondrion"}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU368038"}],"id":"KW-0066","category":"Biological process","name":"ATP synthesis"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU368038"}],"id":"KW-0138","category":"Cellular component","name":"CF(0)"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU368038"}],"id":"KW-0375","category":"Biological process","name":"Hydrogen ion transport"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU368038"}],"id":"KW-0406","category":"Biological process","name":"Ion transport"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023136"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU368038"}],"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU368038"},{"evidenceCode":"ECO:0000313","source":"EMBL","id":"QDA23250.1"}],"id":"KW-0496","category":"Cellular component","name":"Mitochondrion"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022692"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU368038"}],"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022989"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU368038"}],"id":"KW-1133","category":"Domain","name":"Transmembrane helix"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU368038"}],"id":"KW-0813","category":"Biological process","name":"Transport"}],"references":[{"referenceNumber":1,"citation":{"id":"31635252","citationType":"journal article","authors":["Li Q.","Ren Y.","Shi X.","Peng L.","Zhao J.","Song Y.","Zhao G."],"citationCrossReferences":[{"database":"PubMed","id":"31635252"}],"title":"Comparative Mitochondrial Genome Analysis of Two Ectomycorrhizal Fungi (Rhizopogon) Reveals Dynamic Changes of Intron and Phylogenetic Relationships of the Subphylum Agaricomycotina.","publicationDate":"0","journal":"Int. J. Mol. Sci.","firstPage":"0","lastPage":"0","volume":"20"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"QDA23250.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"MH794153","properties":[{"key":"ProteinId","value":"QDA23250.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"RefSeq","id":"YP_009649335.1","properties":[{"key":"NucleotideSequenceId","value":"NC_042699.1"}]},{"database":"AlphaFoldDB","id":"A0A4Y5SI48","properties":[{"key":"Description","value":"-"}]},{"database":"GeneID","id":"40487024","properties":[{"key":"Description","value":"-"}]},{"database":"GO","id":"GO:0005743","properties":[{"key":"GoTerm","value":"C:mitochondrial inner membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0045259","properties":[{"key":"GoTerm","value":"C:proton-transporting ATP synthase complex"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0046933","properties":[{"key":"GoTerm","value":"F:proton-transporting ATP synthase activity, rotational mechanism"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"InterPro","id":"IPR009230","properties":[{"key":"EntryName","value":"ATP_synth_su8_fun"}]},{"database":"PANTHER","id":"PTHR36101","properties":[{"key":"EntryName","value":"ATP SYNTHASE PROTEIN 8"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR36101:SF1","properties":[{"key":"EntryName","value":"ATP SYNTHASE PROTEIN 8"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF05933","properties":[{"key":"EntryName","value":"Fun_ATP-synt_8"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MPQLIPFYFVNQLSFSFLTLIALIYIFSKYILPLFTFQQVIRMYITKLSNKS","length":52,"molWeight":6242,"crc64":"B912B80737DC4403","md5":"57D4D681FB4429E43D3CB36664E3F27E"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"SUBUNIT":1,"SUBCELLULAR LOCATION":1,"SIMILARITY":1},"countByFeatureType":{"Transmembrane":1},"uniParcId":"UPI0011236E7E"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0A4Y5SI52","uniProtkbId":"A0A4Y5SI52_9AGAM","entryAudit":{"firstPublicDate":"2019-09-18","lastAnnotationUpdateDate":"2026-11-04","lastSequenceUpdateDate":"2019-09-18","entryVersion":21,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Rhizopogon vinicolor","taxonId":80600,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"QDA23260.1"}],"lineage":["Eukaryota","Fungi","Dikarya","Basidiomycota","Agaricomycotina","Agaricomycetes","Agaricomycetidae","Boletales","Suillineae","Rhizopogonaceae","Rhizopogon"]},"proteinExistence":"3: Inferred from homology","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00015944"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003375"}],"value":"Cytochrome c oxidase subunit 3"}}},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"QDA23260.1"}],"value":"cox3"}}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003375"}],"value":"Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix"}],"commentType":"FUNCTION"},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"4 Fe(II)-[cytochrome c] + O2 + 8 H(+)(in) = 4 Fe(III)-[cytochrome c] + 2 H2O + 4 H(+)(out)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:11436"},{"database":"Rhea","id":"RHEA-COMP:10350"},{"database":"Rhea","id":"RHEA-COMP:14399"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:15379"},{"database":"ChEBI","id":"CHEBI:29033"},{"database":"ChEBI","id":"CHEBI:29034"}],"ecNumber":"7.1.1.9","evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00049512"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:11437"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00049512"}]}]},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004448"}],"value":"Mitochondrion inner membrane","id":"SL-0168"},"topology":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004448"}],"value":"Multi-pass membrane protein","id":"SL-9909"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00010581"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003375"}],"value":"Belongs to the cytochrome c oxidase subunit 3 family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Transmembrane","location":{"start":{"value":21,"modifier":"EXACT"},"end":{"value":42,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":48,"modifier":"EXACT"},"end":{"value":67,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":88,"modifier":"EXACT"},"end":{"value":111,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":136,"modifier":"EXACT"},"end":{"value":155,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":167,"modifier":"EXACT"},"end":{"value":185,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":205,"modifier":"EXACT"},"end":{"value":229,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":249,"modifier":"EXACT"},"end":{"value":269,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Domain","location":{"start":{"value":11,"modifier":"EXACT"},"end":{"value":270,"modifier":"EXACT"}},"description":"Heme-copper oxidase subunit III family profile","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50253"}]}],"geneLocations":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"QDA23260.1"}],"geneEncodingType":"Mitochondrion"}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023136"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003375"},{"evidenceCode":"ECO:0000313","source":"EMBL","id":"QDA23260.1"}],"id":"KW-0496","category":"Cellular component","name":"Mitochondrion"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022967"}],"id":"KW-1278","category":"Molecular function","name":"Translocase"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022692"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003375"}],"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022989"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-1133","category":"Domain","name":"Transmembrane helix"}],"references":[{"referenceNumber":1,"citation":{"id":"31635252","citationType":"journal article","authors":["Li Q.","Ren Y.","Shi X.","Peng L.","Zhao J.","Song Y.","Zhao G."],"citationCrossReferences":[{"database":"PubMed","id":"31635252"}],"title":"Comparative Mitochondrial Genome Analysis of Two Ectomycorrhizal Fungi (Rhizopogon) Reveals Dynamic Changes of Intron and Phylogenetic Relationships of the Subphylum Agaricomycotina.","publicationDate":"0","journal":"Int. J. Mol. Sci.","firstPage":"0","lastPage":"0","volume":"20"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"QDA23260.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"MH794153","properties":[{"key":"ProteinId","value":"QDA23260.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"RefSeq","id":"YP_009649345.1","properties":[{"key":"NucleotideSequenceId","value":"NC_042699.1"}]},{"database":"AlphaFoldDB","id":"A0A4Y5SI52","properties":[{"key":"Description","value":"-"}]},{"database":"GeneID","id":"40487045","properties":[{"key":"Description","value":"-"}]},{"database":"GO","id":"GO:0005743","properties":[{"key":"GoTerm","value":"C:mitochondrial inner membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0045277","properties":[{"key":"GoTerm","value":"C:respiratory chain complex IV"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0004129","properties":[{"key":"GoTerm","value":"F:cytochrome-c oxidase activity"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-EC"}]},{"database":"GO","id":"GO:0006123","properties":[{"key":"GoTerm","value":"P:mitochondrial electron transport, cytochrome c to oxygen"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"CDD","id":"cd01665","properties":[{"key":"EntryName","value":"Cyt_c_Oxidase_III"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.10.287.70:FF:000082","properties":[{"key":"EntryName","value":"Cytochrome c oxidase subunit 3"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.120.80:FF:000002","properties":[{"key":"EntryName","value":"Cytochrome c oxidase subunit 3"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.10.287.70","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.20.120.80","properties":[{"key":"EntryName","value":"Cytochrome c oxidase, subunit III, four-helix bundle"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR024791","properties":[{"key":"EntryName","value":"Cyt_c/ubiquinol_Oxase_su3"}]},{"database":"InterPro","id":"IPR033945","properties":[{"key":"EntryName","value":"Cyt_c_oxase_su3_dom"}]},{"database":"InterPro","id":"IPR000298","properties":[{"key":"EntryName","value":"Cyt_c_oxidase-like_su3"}]},{"database":"InterPro","id":"IPR035973","properties":[{"key":"EntryName","value":"Cyt_c_oxidase_su3-like_sf"}]},{"database":"InterPro","id":"IPR013833","properties":[{"key":"EntryName","value":"Cyt_c_oxidase_su3_a-hlx"}]},{"database":"PANTHER","id":"PTHR11403:SF7","properties":[{"key":"EntryName","value":"CYTOCHROME C OXIDASE SUBUNIT 3"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR11403","properties":[{"key":"EntryName","value":"CYTOCHROME C OXIDASE SUBUNIT III"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00510","properties":[{"key":"EntryName","value":"COX3"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF81452","properties":[{"key":"EntryName","value":"Cytochrome c oxidase subunit III-like"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50253","properties":[{"key":"EntryName","value":"COX3"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MVQNLNRNQFQYFPYHLVTPSPWPILLSFSLLSMAIGAVMYMHGYVNGGNLLTTGFILTAYGMGLWFRDVVTEGTYLGDHTKQVKKGIQMGVILFIVSEVFAFLSVFWAFFHASLSPSIEIGGIWPPQGITPLDPFAIPLLNTILLVSSGAFVTYGHHALLNANRRGAIIGIFLTILFAVIFTILQYVEYSEAAFTMSDSVYGSAFYASTGLHGLHVIVGTIFILVAFIRLINYHLTDTHHQGCEAAILYWHFVDVVWLFLFIAVYYWGGM","length":271,"molWeight":30296,"crc64":"575E31AC1971750A","md5":"5FD54926ED43E3C466698CC41DF3A152"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"CATALYTIC ACTIVITY":1,"SUBCELLULAR LOCATION":1,"SIMILARITY":1},"countByFeatureType":{"Transmembrane":7,"Domain":1},"uniParcId":"UPI0011211BFC"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0A4Y5SIQ3","uniProtkbId":"A0A4Y5SIQ3_9AGAM","entryAudit":{"firstPublicDate":"2019-09-18","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2019-09-18","entryVersion":15,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Rhizopogon vinicolor","taxonId":80600,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"QDA23249.1"}],"lineage":["Eukaryota","Fungi","Dikarya","Basidiomycota","Agaricomycotina","Agaricomycetes","Agaricomycetidae","Boletales","Suillineae","Rhizopogonaceae","Rhizopogon"]},"proteinExistence":"3: Inferred from homology","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00019317"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU004221"}],"value":"ATP synthase subunit 9, mitochondrial"}}},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"QDA23249.1"}],"value":"atp9"}}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU004221"}],"value":"F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c"}],"commentType":"SUBUNIT"},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004225"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU004221"}],"value":"Mitochondrion membrane","id":"SL-0171"},"topology":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004225"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU004221"}],"value":"Multi-pass membrane protein","id":"SL-9909"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00006704"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU004221"}],"value":"Belongs to the ATPase C chain family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Transmembrane","location":{"start":{"value":7,"modifier":"EXACT"},"end":{"value":33,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU004221"}]},{"type":"Transmembrane","location":{"start":{"value":45,"modifier":"EXACT"},"end":{"value":72,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU004221"}]},{"type":"Domain","location":{"start":{"value":8,"modifier":"EXACT"},"end":{"value":70,"modifier":"EXACT"}},"description":"V-ATPase proteolipid subunit C-like","evidences":[{"evidenceCode":"ECO:0000259","source":"Pfam","id":"PF00137"}]}],"geneLocations":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"QDA23249.1"}],"geneEncodingType":"Mitochondrion"}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022547"}],"id":"KW-0138","category":"Cellular component","name":"CF(0)"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022781"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU004221"}],"id":"KW-0375","category":"Biological process","name":"Hydrogen ion transport"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023065"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU004221"}],"id":"KW-0406","category":"Biological process","name":"Ion transport"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023121"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU004221"}],"id":"KW-0446","category":"Ligand","name":"Lipid-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023136"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU004221"}],"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023128"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU004221"}],"id":"KW-0496","category":"Cellular component","name":"Mitochondrion"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022692"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU004221"}],"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022989"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU004221"}],"id":"KW-1133","category":"Domain","name":"Transmembrane helix"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022448"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU004221"}],"id":"KW-0813","category":"Biological process","name":"Transport"}],"references":[{"referenceNumber":1,"citation":{"id":"31635252","citationType":"journal article","authors":["Li Q.","Ren Y.","Shi X.","Peng L.","Zhao J.","Song Y.","Zhao G."],"citationCrossReferences":[{"database":"PubMed","id":"31635252"}],"title":"Comparative Mitochondrial Genome Analysis of Two Ectomycorrhizal Fungi (Rhizopogon) Reveals Dynamic Changes of Intron and Phylogenetic Relationships of the Subphylum Agaricomycotina.","publicationDate":"0","journal":"Int. J. Mol. Sci.","firstPage":"0","lastPage":"0","volume":"20"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"QDA23249.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"MH794153","properties":[{"key":"ProteinId","value":"QDA23249.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"RefSeq","id":"YP_009649334.1","properties":[{"key":"NucleotideSequenceId","value":"NC_042699.1"}]},{"database":"AlphaFoldDB","id":"A0A4Y5SIQ3","properties":[{"key":"Description","value":"-"}]},{"database":"GeneID","id":"40487022","properties":[{"key":"Description","value":"-"}]},{"database":"GO","id":"GO:0031966","properties":[{"key":"GoTerm","value":"C:mitochondrial membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0045259","properties":[{"key":"GoTerm","value":"C:proton-transporting ATP synthase complex"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0033177","properties":[{"key":"GoTerm","value":"C:proton-transporting two-sector ATPase complex, proton-transporting domain"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0015078","properties":[{"key":"GoTerm","value":"F:proton transmembrane transporter activity"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0015986","properties":[{"key":"GoTerm","value":"P:proton motive force-driven ATP synthesis"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"CDD","id":"cd18182","properties":[{"key":"EntryName","value":"ATP-synt_Fo_c_ATP5G3"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.20.10:FF:000003","properties":[{"key":"EntryName","value":"Atp synthase f complex subunit mitochondrial"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.20.20.10","properties":[{"key":"EntryName","value":"F1F0 ATP synthase subunit C"},{"key":"MatchStatus","value":"1"}]},{"database":"HAMAP","id":"MF_01396","properties":[{"key":"EntryName","value":"ATP_synth_c_bact"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR000454","properties":[{"key":"EntryName","value":"ATP_synth_F0_csu"}]},{"database":"InterPro","id":"IPR020537","properties":[{"key":"EntryName","value":"ATP_synth_F0_csu_DDCD_BS"}]},{"database":"InterPro","id":"IPR038662","properties":[{"key":"EntryName","value":"ATP_synth_F0_csu_sf"}]},{"database":"InterPro","id":"IPR002379","properties":[{"key":"EntryName","value":"ATPase_proteolipid_c-like_dom"}]},{"database":"InterPro","id":"IPR035921","properties":[{"key":"EntryName","value":"F/V-ATP_Csub_sf"}]},{"database":"PANTHER","id":"PTHR10031","properties":[{"key":"EntryName","value":"ATP SYNTHASE LIPID-BINDING PROTEIN, MITOCHONDRIAL"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR10031:SF0","properties":[{"key":"EntryName","value":"ATPASE PROTEIN 9"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00137","properties":[{"key":"EntryName","value":"ATP-synt_C"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR00124","properties":[{"key":"EntryName","value":"ATPASEC"}]},{"database":"SUPFAM","id":"SSF81333","properties":[{"key":"EntryName","value":"F1F0 ATP synthase subunit C"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00605","properties":[{"key":"EntryName","value":"ATPASE_C"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MLAAAKYIGAGLACSGLIGAGAGIGLIFSALIASTARNPQLRGQLFGFAILGFALAEATGLFSLMIAFLLLYS","length":73,"molWeight":7338,"crc64":"A50966E9A601DD6E","md5":"09C8776C4644F224FF394CD97A407EEC"},"extraAttributes":{"countByCommentType":{"SUBUNIT":1,"SUBCELLULAR LOCATION":1,"SIMILARITY":1},"countByFeatureType":{"Transmembrane":2,"Domain":1},"uniParcId":"UPI00111CE5C5"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0A4Y5SIR1","uniProtkbId":"A0A4Y5SIR1_9AGAM","entryAudit":{"firstPublicDate":"2019-09-18","lastAnnotationUpdateDate":"2026-11-04","lastSequenceUpdateDate":"2019-09-18","entryVersion":24,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Rhizopogon vinicolor","taxonId":80600,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"QDA23259.1"}],"lineage":["Eukaryota","Fungi","Dikarya","Basidiomycota","Agaricomycotina","Agaricomycetes","Agaricomycetidae","Boletales","Suillineae","Rhizopogonaceae","Rhizopogon"]},"proteinExistence":"3: Inferred from homology","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00013531"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU362117"}],"value":"Cytochrome b"}}},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"QDA23259.1"}],"value":"cob"}}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU362117"}],"value":"Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain. The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c. Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis"}],"commentType":"FUNCTION"},{"commentType":"COFACTOR","cofactors":[{"name":"heme b","evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU362117"}],"cofactorCrossReference":{"database":"ChEBI","id":"CHEBI:60344"}}],"note":{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU362117"}],"value":"Binds 2 heme groups non-covalently."}]}},{"commentType":"COFACTOR","cofactors":[{"name":"heme","evidences":[{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR038885-2"}],"cofactorCrossReference":{"database":"ChEBI","id":"CHEBI:30413"}}],"note":{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR038885-2"}],"value":"Binds 2 heme groups non-covalently."}]}},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004448"}],"value":"Mitochondrion inner membrane","id":"SL-0168"},"topology":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004448"}],"value":"Multi-pass membrane protein","id":"SL-9909"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00061233"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00968"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU362117"}],"value":"Belongs to the cytochrome b family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Transmembrane","location":{"start":{"value":28,"modifier":"EXACT"},"end":{"value":52,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU362117"}]},{"type":"Transmembrane","location":{"start":{"value":77,"modifier":"EXACT"},"end":{"value":97,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU362117"}]},{"type":"Transmembrane","location":{"start":{"value":112,"modifier":"EXACT"},"end":{"value":134,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU362117"}]},{"type":"Transmembrane","location":{"start":{"value":182,"modifier":"EXACT"},"end":{"value":203,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU362117"}]},{"type":"Transmembrane","location":{"start":{"value":224,"modifier":"EXACT"},"end":{"value":247,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU362117"}]},{"type":"Transmembrane","location":{"start":{"value":289,"modifier":"EXACT"},"end":{"value":308,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU362117"}]},{"type":"Transmembrane","location":{"start":{"value":320,"modifier":"EXACT"},"end":{"value":339,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU362117"}]},{"type":"Transmembrane","location":{"start":{"value":351,"modifier":"EXACT"},"end":{"value":373,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU362117"}]},{"type":"Domain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":210,"modifier":"EXACT"}},"description":"Cytochrome b/b6 N-terminal region profile","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS51002"}]},{"type":"Domain","location":{"start":{"value":211,"modifier":"EXACT"},"end":{"value":381,"modifier":"EXACT"}},"description":"Cytochrome b/b6 C-terminal region profile","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS51003"}]},{"type":"Binding site","location":{"start":{"value":82,"modifier":"EXACT"},"end":{"value":82,"modifier":"EXACT"}},"description":"axial binding residue","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:60344"},{"database":"ChEBI","id":"CHEBI:18248"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR038885-2"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00968"}],"ligand":{"name":"heme b","id":"ChEBI:CHEBI:60344","label":"b562"},"ligandPart":{"name":"Fe","id":"ChEBI:CHEBI:18248"}},{"type":"Binding site","location":{"start":{"value":96,"modifier":"EXACT"},"end":{"value":96,"modifier":"EXACT"}},"description":"axial binding residue","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:60344"},{"database":"ChEBI","id":"CHEBI:18248"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR038885-2"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00968"}],"ligand":{"name":"heme b","id":"ChEBI:CHEBI:60344","label":"b566"},"ligandPart":{"name":"Fe","id":"ChEBI:CHEBI:18248"}},{"type":"Binding site","location":{"start":{"value":183,"modifier":"EXACT"},"end":{"value":183,"modifier":"EXACT"}},"description":"axial binding residue","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:60344"},{"database":"ChEBI","id":"CHEBI:18248"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR038885-2"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00968"}],"ligand":{"name":"heme b","id":"ChEBI:CHEBI:60344","label":"b562"},"ligandPart":{"name":"Fe","id":"ChEBI:CHEBI:18248"}},{"type":"Binding site","location":{"start":{"value":197,"modifier":"EXACT"},"end":{"value":197,"modifier":"EXACT"}},"description":"axial binding residue","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:60344"},{"database":"ChEBI","id":"CHEBI:18248"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR038885-2"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00968"}],"ligand":{"name":"heme b","id":"ChEBI:CHEBI:60344","label":"b566"},"ligandPart":{"name":"Fe","id":"ChEBI:CHEBI:18248"}},{"type":"Binding site","location":{"start":{"value":202,"modifier":"EXACT"},"end":{"value":202,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:16389"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR038885-1"}],"ligand":{"name":"a ubiquinone","id":"ChEBI:CHEBI:16389"}}],"geneLocations":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"QDA23259.1"}],"geneEncodingType":"Mitochondrion"}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022982"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00968"}],"id":"KW-0249","category":"Biological process","name":"Electron transport"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022617"},{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR038885-2"}],"id":"KW-0349","category":"Ligand","name":"Heme"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023004"},{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR038885-2"}],"id":"KW-0408","category":"Ligand","name":"Iron"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023136"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00968"}],"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022723"},{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR038885-2"}],"id":"KW-0479","category":"Ligand","name":"Metal-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023128"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU362117"}],"id":"KW-0496","category":"Cellular component","name":"Mitochondrion"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022792"}],"id":"KW-0999","category":"Cellular component","name":"Mitochondrion inner membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022660"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU362117"}],"id":"KW-0679","category":"Biological process","name":"Respiratory chain"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022692"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00968"}],"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022989"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00968"}],"id":"KW-1133","category":"Domain","name":"Transmembrane helix"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022448"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00968"}],"id":"KW-0813","category":"Biological process","name":"Transport"}],"references":[{"referenceNumber":1,"citation":{"id":"31635252","citationType":"journal article","authors":["Li Q.","Ren Y.","Shi X.","Peng L.","Zhao J.","Song Y.","Zhao G."],"citationCrossReferences":[{"database":"PubMed","id":"31635252"}],"title":"Comparative Mitochondrial Genome Analysis of Two Ectomycorrhizal Fungi (Rhizopogon) Reveals Dynamic Changes of Intron and Phylogenetic Relationships of the Subphylum Agaricomycotina.","publicationDate":"0","journal":"Int. J. Mol. Sci.","firstPage":"0","lastPage":"0","volume":"20"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"QDA23259.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"MH794153","properties":[{"key":"ProteinId","value":"QDA23259.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"RefSeq","id":"YP_009649342.1","properties":[{"key":"NucleotideSequenceId","value":"NC_042699.1"}]},{"database":"AlphaFoldDB","id":"A0A4Y5SIR1","properties":[{"key":"Description","value":"-"}]},{"database":"GeneID","id":"40487043","properties":[{"key":"Description","value":"-"}]},{"database":"GO","id":"GO:0005743","properties":[{"key":"GoTerm","value":"C:mitochondrial inner membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0045275","properties":[{"key":"GoTerm","value":"C:respiratory chain complex III"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0046872","properties":[{"key":"GoTerm","value":"F:metal ion binding"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniRule"}]},{"database":"GO","id":"GO:0008121","properties":[{"key":"GoTerm","value":"F:quinol-cytochrome-c reductase activity"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0006122","properties":[{"key":"GoTerm","value":"P:mitochondrial electron transport, ubiquinol to cytochrome c"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"CDD","id":"cd00290","properties":[{"key":"EntryName","value":"cytochrome_b_C"},{"key":"MatchStatus","value":"1"}]},{"database":"CDD","id":"cd00284","properties":[{"key":"EntryName","value":"Cytochrome_b_N"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.810.10:FF:000002","properties":[{"key":"EntryName","value":"Cytochrome b"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.20.810.10","properties":[{"key":"EntryName","value":"Cytochrome Bc1 Complex, Chain C"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR005798","properties":[{"key":"EntryName","value":"Cyt_b/b6_C"}]},{"database":"InterPro","id":"IPR036150","properties":[{"key":"EntryName","value":"Cyt_b/b6_C_sf"}]},{"database":"InterPro","id":"IPR005797","properties":[{"key":"EntryName","value":"Cyt_b/b6_N"}]},{"database":"InterPro","id":"IPR027387","properties":[{"key":"EntryName","value":"Cytb/b6-like_sf"}]},{"database":"InterPro","id":"IPR030689","properties":[{"key":"EntryName","value":"Cytochrome_b"}]},{"database":"InterPro","id":"IPR048260","properties":[{"key":"EntryName","value":"Cytochrome_b_C_euk/bac"}]},{"database":"InterPro","id":"IPR048259","properties":[{"key":"EntryName","value":"Cytochrome_b_N_euk/bac"}]},{"database":"InterPro","id":"IPR016174","properties":[{"key":"EntryName","value":"Di-haem_cyt_TM"}]},{"database":"PANTHER","id":"PTHR19271","properties":[{"key":"EntryName","value":"CYTOCHROME B"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR19271:SF16","properties":[{"key":"EntryName","value":"CYTOCHROME B"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00032","properties":[{"key":"EntryName","value":"Cytochrom_B_C"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00033","properties":[{"key":"EntryName","value":"Cytochrome_B"},{"key":"MatchStatus","value":"1"}]},{"database":"PIRSF","id":"PIRSF038885","properties":[{"key":"EntryName","value":"COB"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF81648","properties":[{"key":"EntryName","value":"a domain/subunit of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase)"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF81342","properties":[{"key":"EntryName","value":"Transmembrane di-heme cytochromes"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS51003","properties":[{"key":"EntryName","value":"CYTB_CTER"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS51002","properties":[{"key":"EntryName","value":"CYTB_NTER"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MRLLKSHSLLRLVNSYVIDSPQPANISYLWNFGSLLATCLVIQILTGCFLAMHYQSHVDFAFNSVEHIMRDVNNGWVVRYTHANVASFFFIFVYGHIGRNLYYGSYKSPRILVWSIGVIILILMMANSFLGYVLPYGQMSLWGATVITNLLSAIPVFGQDLVELIWGGFSVSNATLNRFFSLHYILPFLLAALALAHLIAVHTHGSSNPNGISSNGDRYSIHPYFMFKDLITIFAFFLVLSVIVFYYPNLLGHSDNYIEANPMSTPSSIVPEWYLLPFYAILRSIPNKLLGVLAMFGSLFILFILPLVDVSRIRGNQFRPAMRVSFWFFVVNFFILMWIGSQHPDSPYLEIGQISTALYFIWFLIVIPVIGLAENTLMDIATEN","length":384,"molWeight":43576,"crc64":"5F12401E886E8443","md5":"13AAB69971BE5B3C7BB418D2635664C6"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"COFACTOR":2,"SUBCELLULAR LOCATION":1,"SIMILARITY":1},"countByFeatureType":{"Transmembrane":8,"Domain":2,"Binding site":5},"uniParcId":"UPI00111D36E0"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0A4Y5SJI9","uniProtkbId":"A0A4Y5SJI9_9AGAM","entryAudit":{"firstPublicDate":"2019-09-18","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2019-09-18","entryVersion":24,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Rhizopogon vinicolor","taxonId":80600,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"QDA23244.1"}],"lineage":["Eukaryota","Fungi","Dikarya","Basidiomycota","Agaricomycotina","Agaricomycetes","Agaricomycetidae","Boletales","Suillineae","Rhizopogonaceae","Rhizopogon"]},"proteinExistence":"3: Inferred from homology","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00015946"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000457"}],"value":"Cytochrome c oxidase subunit 2"}}},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"QDA23244.1"}],"value":"cox2"}}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000457"}],"value":"Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix"}],"commentType":"FUNCTION"},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"4 Fe(II)-[cytochrome c] + O2 + 8 H(+)(in) = 4 Fe(III)-[cytochrome c] + 2 H2O + 4 H(+)(out)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:11436"},{"database":"Rhea","id":"RHEA-COMP:10350"},{"database":"Rhea","id":"RHEA-COMP:14399"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:15379"},{"database":"ChEBI","id":"CHEBI:29033"},{"database":"ChEBI","id":"CHEBI:29034"}],"ecNumber":"7.1.1.9","evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00049512"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:11437"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00049512"}]}]},{"commentType":"COFACTOR","cofactors":[{"name":"Cu cation","evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000457"}],"cofactorCrossReference":{"database":"ChEBI","id":"CHEBI:23378"}}],"note":{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000457"}],"value":"Binds a copper A center."}]}},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004448"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000457"}],"value":"Mitochondrion inner membrane","id":"SL-0168"},"topology":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004448"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000457"}],"value":"Multi-pass membrane protein","id":"SL-9909"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00007866"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000457"}],"value":"Belongs to the cytochrome c oxidase subunit 2 family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Transmembrane","location":{"start":{"value":41,"modifier":"EXACT"},"end":{"value":63,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":83,"modifier":"EXACT"},"end":{"value":105,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Domain","location":{"start":{"value":15,"modifier":"EXACT"},"end":{"value":111,"modifier":"EXACT"}},"description":"Cytochrome oxidase subunit II transmembrane region profile","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50999"}]},{"type":"Domain","location":{"start":{"value":112,"modifier":"EXACT"},"end":{"value":250,"modifier":"EXACT"}},"description":"Cytochrome oxidase subunit II copper A binding","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50857"}]}],"geneLocations":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"QDA23244.1"}],"geneEncodingType":"Mitochondrion"}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023008"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000457"}],"id":"KW-0186","category":"Ligand","name":"Copper"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022982"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000457"}],"id":"KW-0249","category":"Biological process","name":"Electron transport"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023136"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000457"}],"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022723"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000457"}],"id":"KW-0479","category":"Ligand","name":"Metal-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023128"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000457"}],"id":"KW-0496","category":"Cellular component","name":"Mitochondrion"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000457"}],"id":"KW-0999","category":"Cellular component","name":"Mitochondrion inner membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022660"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000457"}],"id":"KW-0679","category":"Biological process","name":"Respiratory chain"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022967"}],"id":"KW-1278","category":"Molecular function","name":"Translocase"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022692"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000457"}],"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022989"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-1133","category":"Domain","name":"Transmembrane helix"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022448"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000457"}],"id":"KW-0813","category":"Biological process","name":"Transport"}],"references":[{"referenceNumber":1,"citation":{"id":"31635252","citationType":"journal article","authors":["Li Q.","Ren Y.","Shi X.","Peng L.","Zhao J.","Song Y.","Zhao G."],"citationCrossReferences":[{"database":"PubMed","id":"31635252"}],"title":"Comparative Mitochondrial Genome Analysis of Two Ectomycorrhizal Fungi (Rhizopogon) Reveals Dynamic Changes of Intron and Phylogenetic Relationships of the Subphylum Agaricomycotina.","publicationDate":"0","journal":"Int. J. Mol. Sci.","firstPage":"0","lastPage":"0","volume":"20"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"QDA23244.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"MH794153","properties":[{"key":"ProteinId","value":"QDA23244.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"RefSeq","id":"YP_009649329.1","properties":[{"key":"NucleotideSequenceId","value":"NC_042699.1"}]},{"database":"AlphaFoldDB","id":"A0A4Y5SJI9","properties":[{"key":"Description","value":"-"}]},{"database":"GeneID","id":"40487012","properties":[{"key":"Description","value":"-"}]},{"database":"GO","id":"GO:0005743","properties":[{"key":"GoTerm","value":"C:mitochondrial inner membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0045277","properties":[{"key":"GoTerm","value":"C:respiratory chain complex IV"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0005507","properties":[{"key":"GoTerm","value":"F:copper ion binding"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0004129","properties":[{"key":"GoTerm","value":"F:cytochrome-c oxidase activity"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-EC"}]},{"database":"GO","id":"GO:0006123","properties":[{"key":"GoTerm","value":"P:mitochondrial electron transport, cytochrome c to oxygen"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"CDD","id":"cd13912","properties":[{"key":"EntryName","value":"CcO_II_C"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.10.287.90:FF:000004","properties":[{"key":"EntryName","value":"Cytochrome c oxidase subunit 2"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.60.40.420:FF:000001","properties":[{"key":"EntryName","value":"Cytochrome c oxidase subunit 2"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.10.287.90","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.60.40.420","properties":[{"key":"EntryName","value":"Cupredoxins - blue copper proteins"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR045187","properties":[{"key":"EntryName","value":"CcO_II"}]},{"database":"InterPro","id":"IPR002429","properties":[{"key":"EntryName","value":"CcO_II-like_C"}]},{"database":"InterPro","id":"IPR034210","properties":[{"key":"EntryName","value":"CcO_II_C"}]},{"database":"InterPro","id":"IPR001505","properties":[{"key":"EntryName","value":"Copper_CuA"}]},{"database":"InterPro","id":"IPR008972","properties":[{"key":"EntryName","value":"Cupredoxin"}]},{"database":"InterPro","id":"IPR014222","properties":[{"key":"EntryName","value":"Cyt_c_oxidase_su2"}]},{"database":"InterPro","id":"IPR011759","properties":[{"key":"EntryName","value":"Cyt_c_oxidase_su2_TM_dom"}]},{"database":"InterPro","id":"IPR036257","properties":[{"key":"EntryName","value":"Cyt_c_oxidase_su2_TM_sf"}]},{"database":"NCBIfam","id":"TIGR02866","properties":[{"key":"EntryName","value":"CoxB"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR22888:SF9","properties":[{"key":"EntryName","value":"CYTOCHROME C OXIDASE SUBUNIT 2"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR22888","properties":[{"key":"EntryName","value":"CYTOCHROME C OXIDASE, SUBUNIT II"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00116","properties":[{"key":"EntryName","value":"COX2"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF02790","properties":[{"key":"EntryName","value":"COX2_TM"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR01166","properties":[{"key":"EntryName","value":"CYCOXIDASEII"}]},{"database":"SUPFAM","id":"SSF49503","properties":[{"key":"EntryName","value":"Cupredoxins"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF81464","properties":[{"key":"EntryName","value":"Cytochrome c oxidase subunit II-like, transmembrane region"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00078","properties":[{"key":"EntryName","value":"COX2"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50857","properties":[{"key":"EntryName","value":"COX2_CUA"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50999","properties":[{"key":"EntryName","value":"COX2_TM"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MLKNISIFNTIFNDAPQPWQISFQDSAAPAFTGIVELHNTIFFYLIITCVGVFWVLGSVMYYYNSTNSPIVHKYLNHGTLIELIWTITPALILIVIAFPSFRLLYLLDEVTSPTITIKVVGHQWYWSYEYSDYVNENGNSVEFDSYMIPESDLELGQLRLLDVDNKMVIPVDCHIRLIVTGADVIHSFAVPSLGLKIDATPGRLNQSSILAERTGTFYGQCSEICGVWHGFMPIAVEAVSVQDYLAWIDSV","length":251,"molWeight":28315,"crc64":"7F0198CF7096978C","md5":"41381895070C24EDBBCEA5F61EE286C8"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"CATALYTIC ACTIVITY":1,"COFACTOR":1,"SUBCELLULAR LOCATION":1,"SIMILARITY":1},"countByFeatureType":{"Transmembrane":2,"Domain":2},"uniParcId":"UPI00112414CB"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0A4Y5SJJ8","uniProtkbId":"A0A4Y5SJJ8_9AGAM","entryAudit":{"firstPublicDate":"2019-09-18","lastAnnotationUpdateDate":"2026-11-04","lastSequenceUpdateDate":"2019-09-18","entryVersion":17,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Rhizopogon vinicolor","taxonId":80600,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"QDA23254.1"}],"lineage":["Eukaryota","Fungi","Dikarya","Basidiomycota","Agaricomycotina","Agaricomycetes","Agaricomycetidae","Boletales","Suillineae","Rhizopogonaceae","Rhizopogon"]},"proteinExistence":"3: Inferred from homology","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00021008"}],"value":"NADH-ubiquinone oxidoreductase chain 2"}},"alternativeNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00031028"}],"value":"NADH dehydrogenase subunit 2"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"QDA23254.1"}],"value":"nad2"}}],"comments":[{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"a ubiquinone + NADH + 5 H(+)(in) = a ubiquinol + NAD(+) + 4 H(+)(out)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:29091"},{"database":"Rhea","id":"RHEA-COMP:9565"},{"database":"Rhea","id":"RHEA-COMP:9566"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:16389"},{"database":"ChEBI","id":"CHEBI:17976"},{"database":"ChEBI","id":"CHEBI:57540"},{"database":"ChEBI","id":"CHEBI:57945"}],"ecNumber":"7.1.1.2","evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00049551"}]}},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004141"}],"value":"Membrane","id":"SL-0162"},"topology":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004141"}],"value":"Multi-pass membrane protein","id":"SL-9909"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00007012"}],"value":"Belongs to the complex I subunit 2 family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Transmembrane","location":{"start":{"value":70,"modifier":"EXACT"},"end":{"value":89,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":122,"modifier":"EXACT"},"end":{"value":143,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":176,"modifier":"EXACT"},"end":{"value":197,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":217,"modifier":"EXACT"},"end":{"value":235,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":256,"modifier":"EXACT"},"end":{"value":274,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":306,"modifier":"EXACT"},"end":{"value":331,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":338,"modifier":"EXACT"},"end":{"value":356,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":368,"modifier":"EXACT"},"end":{"value":389,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":417,"modifier":"EXACT"},"end":{"value":437,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":457,"modifier":"EXACT"},"end":{"value":477,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":511,"modifier":"EXACT"},"end":{"value":531,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Domain","location":{"start":{"value":141,"modifier":"EXACT"},"end":{"value":274,"modifier":"EXACT"}},"description":"NADH:quinone oxidoreductase/Mrp antiporter transmembrane","evidences":[{"evidenceCode":"ECO:0000259","source":"Pfam","id":"PF00361"}]},{"type":"Domain","location":{"start":{"value":305,"modifier":"EXACT"},"end":{"value":472,"modifier":"EXACT"}},"description":"NADH:quinone oxidoreductase/Mrp antiporter transmembrane","evidences":[{"evidenceCode":"ECO:0000259","source":"Pfam","id":"PF00361"}]}],"geneLocations":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"QDA23254.1"}],"geneEncodingType":"Mitochondrion"}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023136"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"QDA23254.1"}],"id":"KW-0496","category":"Cellular component","name":"Mitochondrion"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022692"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022989"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-1133","category":"Domain","name":"Transmembrane helix"}],"references":[{"referenceNumber":1,"citation":{"id":"31635252","citationType":"journal article","authors":["Li Q.","Ren Y.","Shi X.","Peng L.","Zhao J.","Song Y.","Zhao G."],"citationCrossReferences":[{"database":"PubMed","id":"31635252"}],"title":"Comparative Mitochondrial Genome Analysis of Two Ectomycorrhizal Fungi (Rhizopogon) Reveals Dynamic Changes of Intron and Phylogenetic Relationships of the Subphylum Agaricomycotina.","publicationDate":"0","journal":"Int. J. Mol. Sci.","firstPage":"0","lastPage":"0","volume":"20"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"QDA23254.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"MH794153","properties":[{"key":"ProteinId","value":"QDA23254.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"RefSeq","id":"YP_009649339.1","properties":[{"key":"NucleotideSequenceId","value":"NC_042699.1"}]},{"database":"AlphaFoldDB","id":"A0A4Y5SJJ8","properties":[{"key":"Description","value":"-"}]},{"database":"GeneID","id":"40487030","properties":[{"key":"Description","value":"-"}]},{"database":"GO","id":"GO:0016020","properties":[{"key":"GoTerm","value":"C:membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0008137","properties":[{"key":"GoTerm","value":"F:NADH dehydrogenase (ubiquinone) activity"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-EC"}]},{"database":"GO","id":"GO:0042773","properties":[{"key":"GoTerm","value":"P:ATP synthesis coupled electron transport"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"HAMAP","id":"MF_00445","properties":[{"key":"EntryName","value":"NDH1_NuoN_1"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR010096","properties":[{"key":"EntryName","value":"NADH-Q_OxRdtase_suN/2"}]},{"database":"InterPro","id":"IPR001750","properties":[{"key":"EntryName","value":"ND/Mrp_TM"}]},{"database":"PANTHER","id":"PTHR22773","properties":[{"key":"EntryName","value":"NADH DEHYDROGENASE"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00361","properties":[{"key":"EntryName","value":"Proton_antipo_M"},{"key":"MatchStatus","value":"2"}]}],"sequence":{"value":"MIFISILILIVAIALPSFQKNFSPILFTRLSSIIFIYAGVLSFNTLYIESIGSGLGIYSGLFHVTVSSEIMDTFLFLMASLILIAWPIINNSVLTVKNDTVNKTKNLPQHKVGKAINPSTEYSLIVMFSTLGASLLLSCADLVSMYLSIELQSFGVYILSTLYRDSESATSAGLKYFLLGGLSSCIILLGSALIYSYTGLTNFESIYSLVSVSYSNQIIHGLTLGFILIFIGLLFKIAAAPLHNWAPDVYDDSPTIVTIWLTIMPKISIIILLLELQSGISLSSEIELIESLKSINILSDLLSENIIYVLKNLLLISSLLSLIIGTVVGLAQTKIKRLLAYSTISHIGFILLALAINTEQSTESLIFYIIQYSFTNLNVFLIIIALGYLTHINKFINGNFYGSNTDIRFISDLKGQFFLNPILSISLTICLFSMAGVPPLIGFFSKQFVLYSALQSGYYFMSIVAILVSVISASYYLKIIRVLHTEENITTEKITNSNETNNSVLSNLHSFLISILTLSILLFVLKPSIILNSTQLLSLTLFNF","length":544,"molWeight":60032,"crc64":"725DBB40E60F90AE","md5":"AD1BD80279F84A2E2ECD22A5989FDF9F"},"extraAttributes":{"countByCommentType":{"CATALYTIC ACTIVITY":1,"SUBCELLULAR LOCATION":1,"SIMILARITY":1},"countByFeatureType":{"Transmembrane":11,"Domain":2},"uniParcId":"UPI001120C5F6"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0A4Y5SJR8","uniProtkbId":"A0A4Y5SJR8_9AGAM","entryAudit":{"firstPublicDate":"2019-09-18","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2019-09-18","entryVersion":16,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Rhizopogon vinicolor","taxonId":80600,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"QDA23246.1"}],"lineage":["Eukaryota","Fungi","Dikarya","Basidiomycota","Agaricomycotina","Agaricomycetes","Agaricomycetidae","Boletales","Suillineae","Rhizopogonaceae","Rhizopogon"]},"proteinExistence":"3: Inferred from homology","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00014385"}],"value":"Probable DNA polymerase"},"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00012417"}],"value":"2.7.7.7"}]}},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"QDA23246.1"}],"value":"orf232"}}],"comments":[{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:22508"},{"database":"Rhea","id":"RHEA-COMP:17339"},{"database":"Rhea","id":"RHEA-COMP:17340"},{"database":"ChEBI","id":"CHEBI:33019"},{"database":"ChEBI","id":"CHEBI:61560"},{"database":"ChEBI","id":"CHEBI:173112"}],"ecNumber":"2.7.7.7","evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00049244"}]}},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00005755"}],"value":"Belongs to the DNA polymerase type-B family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Domain","location":{"start":{"value":38,"modifier":"EXACT"},"end":{"value":229,"modifier":"EXACT"}},"description":"DNA-directed DNA polymerase family B mitochondria/virus","evidences":[{"evidenceCode":"ECO:0000259","source":"Pfam","id":"PF03175"}]}],"geneLocations":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"QDA23246.1"}],"geneEncodingType":"Mitochondrion"}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022705"}],"id":"KW-0235","category":"Biological process","name":"DNA replication"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023125"}],"id":"KW-0238","category":"Molecular function","name":"DNA-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022932"}],"id":"KW-0239","category":"Molecular function","name":"DNA-directed DNA polymerase"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"QDA23246.1"}],"id":"KW-0496","category":"Cellular component","name":"Mitochondrion"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022695"}],"id":"KW-0548","category":"Molecular function","name":"Nucleotidyltransferase"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022679"}],"id":"KW-0808","category":"Molecular function","name":"Transferase"}],"references":[{"referenceNumber":1,"citation":{"id":"31635252","citationType":"journal article","authors":["Li Q.","Ren Y.","Shi X.","Peng L.","Zhao J.","Song Y.","Zhao G."],"citationCrossReferences":[{"database":"PubMed","id":"31635252"}],"title":"Comparative Mitochondrial Genome Analysis of Two Ectomycorrhizal Fungi (Rhizopogon) Reveals Dynamic Changes of Intron and Phylogenetic Relationships of the Subphylum Agaricomycotina.","publicationDate":"0","journal":"Int. J. Mol. Sci.","firstPage":"0","lastPage":"0","volume":"20"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"QDA23246.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"MH794153","properties":[{"key":"ProteinId","value":"QDA23246.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"RefSeq","id":"YP_009649331.1","properties":[{"key":"NucleotideSequenceId","value":"NC_042699.1"}]},{"database":"AlphaFoldDB","id":"A0A4Y5SJR8","properties":[{"key":"Description","value":"-"}]},{"database":"GeneID","id":"40487019","properties":[{"key":"Description","value":"-"}]},{"database":"GO","id":"GO:0003677","properties":[{"key":"GoTerm","value":"F:DNA binding"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0003887","properties":[{"key":"GoTerm","value":"F:DNA-directed DNA polymerase activity"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-EC"}]},{"database":"GO","id":"GO:0000166","properties":[{"key":"GoTerm","value":"F:nucleotide binding"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0006260","properties":[{"key":"GoTerm","value":"P:DNA replication"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"Gene3D","id":"3.30.420.10","properties":[{"key":"EntryName","value":"Ribonuclease H-like superfamily/Ribonuclease H"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR004868","properties":[{"key":"EntryName","value":"DNA-dir_DNA_pol_B_mt/vir"}]},{"database":"InterPro","id":"IPR012337","properties":[{"key":"EntryName","value":"RNaseH-like_sf"}]},{"database":"InterPro","id":"IPR036397","properties":[{"key":"EntryName","value":"RNaseH_sf"}]},{"database":"PANTHER","id":"PTHR33568","properties":[{"key":"EntryName","value":"DNA POLYMERASE"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR33568:SF3","properties":[{"key":"EntryName","value":"DNA-DIRECTED DNA POLYMERASE"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF03175","properties":[{"key":"EntryName","value":"DNA_pol_B_2"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF53098","properties":[{"key":"EntryName","value":"Ribonuclease H-like"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MTPYCICFYDGKSSKSFYLTDYKDSQEMLKFAISSLLKRKYKGYKIYVHNLSNFDGIFLLKILSSINHIKVQPILKDGKIINLKLNYDSINSYQINFRDSFLILPSSLRKLAIQFKVDNKTLFPYNFVNDKYNKNIDLNYIGSVPLIKYFINISLEDYNQYKLLFNKNWSLKDESIKYCNQDCISLYQIIHKFNILIYDKYHINIHKYPTLPSLAFGIYRTHYLKDYPIPLI","length":232,"molWeight":27629,"crc64":"223E304631B696B3","md5":"9C3B8FF606F4925DC42AC8FD3155E8A9"},"extraAttributes":{"countByCommentType":{"CATALYTIC ACTIVITY":1,"SIMILARITY":1},"countByFeatureType":{"Domain":1},"uniParcId":"UPI00111CC7E1"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0A4Y5SJS0","uniProtkbId":"A0A4Y5SJS0_9AGAM","entryAudit":{"firstPublicDate":"2019-09-18","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2019-09-18","entryVersion":16,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Rhizopogon vinicolor","taxonId":80600,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"QDA23256.1"}],"lineage":["Eukaryota","Fungi","Dikarya","Basidiomycota","Agaricomycotina","Agaricomycetes","Agaricomycetidae","Boletales","Suillineae","Rhizopogonaceae","Rhizopogon"]},"proteinExistence":"3: Inferred from homology","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000473"}],"value":"NADH-ubiquinone oxidoreductase chain 1"},"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000473"}],"value":"7.1.1.2"}]}},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"QDA23256.1"}],"value":"nad1"}}],"comments":[{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"a ubiquinone + NADH + 5 H(+)(in) = a ubiquinol + NAD(+) + 4 H(+)(out)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:29091"},{"database":"Rhea","id":"RHEA-COMP:9565"},{"database":"Rhea","id":"RHEA-COMP:9566"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:16389"},{"database":"ChEBI","id":"CHEBI:17976"},{"database":"ChEBI","id":"CHEBI:57540"},{"database":"ChEBI","id":"CHEBI:57945"}],"ecNumber":"7.1.1.2","evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000473"}]}},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004141"}],"value":"Membrane","id":"SL-0162"},"topology":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004141"}],"value":"Multi-pass membrane protein","id":"SL-9909"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000471"}],"value":"Mitochondrion inner membrane","id":"SL-0168"},"topology":{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000471"}],"value":"Multi-pass membrane protein","id":"SL-9909"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00010535"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000471"}],"value":"Belongs to the complex I subunit 1 family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Transmembrane","location":{"start":{"value":6,"modifier":"EXACT"},"end":{"value":37,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":83,"modifier":"EXACT"},"end":{"value":105,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":117,"modifier":"EXACT"},"end":{"value":139,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":160,"modifier":"EXACT"},"end":{"value":182,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":188,"modifier":"EXACT"},"end":{"value":207,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":236,"modifier":"EXACT"},"end":{"value":262,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":274,"modifier":"EXACT"},"end":{"value":295,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":307,"modifier":"EXACT"},"end":{"value":333,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]}],"geneLocations":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"QDA23256.1"}],"geneEncodingType":"Mitochondrion"}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023136"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000473"},{"evidenceCode":"ECO:0000313","source":"EMBL","id":"QDA23256.1"}],"id":"KW-0496","category":"Cellular component","name":"Mitochondrion"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000471"}],"id":"KW-0520","category":"Ligand","name":"NAD"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022692"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000471"}],"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022989"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-1133","category":"Domain","name":"Transmembrane helix"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000473"}],"id":"KW-0830","category":"Ligand","name":"Ubiquinone"}],"references":[{"referenceNumber":1,"citation":{"id":"31635252","citationType":"journal article","authors":["Li Q.","Ren Y.","Shi X.","Peng L.","Zhao J.","Song Y.","Zhao G."],"citationCrossReferences":[{"database":"PubMed","id":"31635252"}],"title":"Comparative Mitochondrial Genome Analysis of Two Ectomycorrhizal Fungi (Rhizopogon) Reveals Dynamic Changes of Intron and Phylogenetic Relationships of the Subphylum Agaricomycotina.","publicationDate":"0","journal":"Int. J. Mol. Sci.","firstPage":"0","lastPage":"0","volume":"20"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"QDA23256.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"MH794153","properties":[{"key":"ProteinId","value":"QDA23256.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"RefSeq","id":"YP_009649341.1","properties":[{"key":"NucleotideSequenceId","value":"NC_042699.1"}]},{"database":"AlphaFoldDB","id":"A0A4Y5SJS0","properties":[{"key":"Description","value":"-"}]},{"database":"GeneID","id":"40487041","properties":[{"key":"Description","value":"-"}]},{"database":"GO","id":"GO:0005743","properties":[{"key":"GoTerm","value":"C:mitochondrial inner membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0008137","properties":[{"key":"GoTerm","value":"F:NADH dehydrogenase (ubiquinone) activity"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-EC"}]},{"database":"GO","id":"GO:0009060","properties":[{"key":"GoTerm","value":"P:aerobic respiration"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"HAMAP","id":"MF_01350","properties":[{"key":"EntryName","value":"NDH1_NuoH"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR001694","properties":[{"key":"EntryName","value":"NADH_UbQ_OxRdtase_su1/FPO"}]},{"database":"InterPro","id":"IPR018086","properties":[{"key":"EntryName","value":"NADH_UbQ_OxRdtase_su1_CS"}]},{"database":"PANTHER","id":"PTHR11432","properties":[{"key":"EntryName","value":"NADH DEHYDROGENASE SUBUNIT 1"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR11432:SF3","properties":[{"key":"EntryName","value":"NADH-UBIQUINONE OXIDOREDUCTASE CHAIN 1"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00146","properties":[{"key":"EntryName","value":"NADHdh"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00667","properties":[{"key":"EntryName","value":"COMPLEX1_ND1_1"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MINNNFILTILNLLINLIDVLVVLLPILLSVAFMTIIERKQLAAHQRRVGPQVVGYYGILQPFSDALKLILKETVIPSQSNKVLFYLAPVSTLIFSLLGWAIIPFGQGLTLFDFSLGIFYTLALSSLGVYGILFAGWSANSKYAFLGSLRSTAAMISYELILSSAILIIILLAGSFNFSTIIETQQAVWFIVPLLPIFIFYFIAILAETSRTPFDLQEAESELVAGFFTEHSSVPFVFFFLAEYSSIVLFSCLTAILFLGGYNFPEIIVNNTIINLQAIILGLKTCIFCFMFVWFRATLPRLRYDQLIDLCWVNILPIAVAFIIFVPSLLVAFDIAPY","length":338,"molWeight":37800,"crc64":"125CF5D5DB8A63C3","md5":"2FFF56E8379E13F54FC48A0E67CDB387"},"extraAttributes":{"countByCommentType":{"CATALYTIC ACTIVITY":1,"SUBCELLULAR LOCATION":1,"SIMILARITY":1},"countByFeatureType":{"Transmembrane":8},"uniParcId":"UPI00111CF6C9"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0A4Y5SJS9","uniProtkbId":"A0A4Y5SJS9_9AGAM","entryAudit":{"firstPublicDate":"2019-09-18","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2019-09-18","entryVersion":23,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Rhizopogon vinicolor","taxonId":80600,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"QDA23266.1"}],"lineage":["Eukaryota","Fungi","Dikarya","Basidiomycota","Agaricomycotina","Agaricomycetes","Agaricomycetidae","Boletales","Suillineae","Rhizopogonaceae","Rhizopogon"]},"proteinExistence":"3: Inferred from homology","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003297"}],"value":"NADH-ubiquinone oxidoreductase chain 4"},"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003297"}],"value":"7.1.1.2"}]}},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"QDA23266.1"}],"value":"nad4"}}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00003257"}],"value":"Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003297"}],"value":"Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I"}],"commentType":"FUNCTION"},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"a ubiquinone + NADH + 5 H(+)(in) = a ubiquinol + NAD(+) + 4 H(+)(out)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:29091"},{"database":"Rhea","id":"RHEA-COMP:9565"},{"database":"Rhea","id":"RHEA-COMP:9566"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:16389"},{"database":"ChEBI","id":"CHEBI:17976"},{"database":"ChEBI","id":"CHEBI:57540"},{"database":"ChEBI","id":"CHEBI:57945"}],"ecNumber":"7.1.1.2","evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003297"}]}},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004141"}],"value":"Membrane","id":"SL-0162"},"topology":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004141"}],"value":"Multi-pass membrane protein","id":"SL-9909"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003297"}],"value":"Mitochondrion membrane","id":"SL-0171"},"topology":{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003297"}],"value":"Multi-pass membrane protein","id":"SL-9909"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00009025"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003297"}],"value":"Belongs to the complex I subunit 4 family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Transmembrane","location":{"start":{"value":32,"modifier":"EXACT"},"end":{"value":52,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003297"}]},{"type":"Transmembrane","location":{"start":{"value":72,"modifier":"EXACT"},"end":{"value":97,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003297"}]},{"type":"Transmembrane","location":{"start":{"value":109,"modifier":"EXACT"},"end":{"value":127,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003297"}]},{"type":"Transmembrane","location":{"start":{"value":133,"modifier":"EXACT"},"end":{"value":152,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003297"}]},{"type":"Transmembrane","location":{"start":{"value":164,"modifier":"EXACT"},"end":{"value":186,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003297"}]},{"type":"Transmembrane","location":{"start":{"value":206,"modifier":"EXACT"},"end":{"value":229,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003297"}]},{"type":"Transmembrane","location":{"start":{"value":241,"modifier":"EXACT"},"end":{"value":263,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003297"}]},{"type":"Transmembrane","location":{"start":{"value":269,"modifier":"EXACT"},"end":{"value":291,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003297"}]},{"type":"Transmembrane","location":{"start":{"value":298,"modifier":"EXACT"},"end":{"value":319,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003297"}]},{"type":"Transmembrane","location":{"start":{"value":325,"modifier":"EXACT"},"end":{"value":348,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003297"}]},{"type":"Transmembrane","location":{"start":{"value":368,"modifier":"EXACT"},"end":{"value":390,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003297"}]},{"type":"Transmembrane","location":{"start":{"value":402,"modifier":"EXACT"},"end":{"value":425,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003297"}]},{"type":"Transmembrane","location":{"start":{"value":450,"modifier":"EXACT"},"end":{"value":471,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003297"}]},{"type":"Domain","location":{"start":{"value":129,"modifier":"EXACT"},"end":{"value":414,"modifier":"EXACT"}},"description":"NADH:quinone oxidoreductase/Mrp antiporter transmembrane","evidences":[{"evidenceCode":"ECO:0000259","source":"Pfam","id":"PF00361"}]}],"geneLocations":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"QDA23266.1"}],"geneEncodingType":"Mitochondrion"}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003297"}],"id":"KW-0249","category":"Biological process","name":"Electron transport"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023136"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003297"}],"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003297"},{"evidenceCode":"ECO:0000313","source":"EMBL","id":"QDA23266.1"}],"id":"KW-0496","category":"Cellular component","name":"Mitochondrion"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003297"}],"id":"KW-0520","category":"Ligand","name":"NAD"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003297"}],"id":"KW-0679","category":"Biological process","name":"Respiratory chain"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022692"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003297"}],"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022989"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003297"}],"id":"KW-1133","category":"Domain","name":"Transmembrane helix"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003297"}],"id":"KW-0813","category":"Biological process","name":"Transport"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003297"}],"id":"KW-0830","category":"Ligand","name":"Ubiquinone"}],"references":[{"referenceNumber":1,"citation":{"id":"31635252","citationType":"journal article","authors":["Li Q.","Ren Y.","Shi X.","Peng L.","Zhao J.","Song Y.","Zhao G."],"citationCrossReferences":[{"database":"PubMed","id":"31635252"}],"title":"Comparative Mitochondrial Genome Analysis of Two Ectomycorrhizal Fungi (Rhizopogon) Reveals Dynamic Changes of Intron and Phylogenetic Relationships of the Subphylum Agaricomycotina.","publicationDate":"0","journal":"Int. J. Mol. Sci.","firstPage":"0","lastPage":"0","volume":"20"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"QDA23266.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"MH794153","properties":[{"key":"ProteinId","value":"QDA23266.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"RefSeq","id":"YP_009649351.1","properties":[{"key":"NucleotideSequenceId","value":"NC_042699.1"}]},{"database":"AlphaFoldDB","id":"A0A4Y5SJS9","properties":[{"key":"Description","value":"-"}]},{"database":"GeneID","id":"40487051","properties":[{"key":"Description","value":"-"}]},{"database":"GO","id":"GO:0031966","properties":[{"key":"GoTerm","value":"C:mitochondrial membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0008137","properties":[{"key":"GoTerm","value":"F:NADH dehydrogenase (ubiquinone) activity"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniRule"}]},{"database":"GO","id":"GO:0048039","properties":[{"key":"GoTerm","value":"F:ubiquinone binding"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:0042773","properties":[{"key":"GoTerm","value":"P:ATP synthesis coupled electron transport"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0015990","properties":[{"key":"GoTerm","value":"P:electron transport coupled proton transport"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"InterPro","id":"IPR010227","properties":[{"key":"EntryName","value":"NADH_Q_OxRdtase_chainM/4"}]},{"database":"InterPro","id":"IPR003918","properties":[{"key":"EntryName","value":"NADH_UbQ_OxRdtase"}]},{"database":"InterPro","id":"IPR001750","properties":[{"key":"EntryName","value":"ND/Mrp_TM"}]},{"database":"NCBIfam","id":"TIGR01972","properties":[{"key":"EntryName","value":"NDH_I_M"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR43507","properties":[{"key":"EntryName","value":"NADH-UBIQUINONE OXIDOREDUCTASE CHAIN 4"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR43507:SF1","properties":[{"key":"EntryName","value":"NADH-UBIQUINONE OXIDOREDUCTASE CHAIN 4"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00361","properties":[{"key":"EntryName","value":"Proton_antipo_M"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR01437","properties":[{"key":"EntryName","value":"NUOXDRDTASE4"}]}],"sequence":{"value":"MITLLLLIPIIGSLLIIPIQEDSLKSQLKMKIIAISTSLLNLFISIFLWLEFDSNTTQYQFVYEFDHLSFCHFNLGVDGISLFFVLLTTFITPIAIISNYNNITKNLKYFLISFLILETLQLALFLVLDLLLFYIFFESVLPILFIVIIVYGSGEFRYRSANLFFLYTLFGSLFMLLAILQIYSYTGSTDFQFISLFEISLDSQKILWLSFFLAFAIKTPLWPFTGWLYRAHADSPLAGSIILAATILKFATYGYIRVLINFLPDASNYFGPLVQTIAIVTLIFASLATIVQQDTKTLIAYSSIAHMSIVILGLFSNTIQGIEGAILLALAHGFVSPALFICVGGVIYDRTGTRVIKYIKGLASYMPIFTIIFFIFTLCNTGIPLSLNFLGEQLSLIGIWEINPIISALGATGIVLSACYSIFLYNRISYGVYSPNMNSVSLLDISRREFVILISLLIPTILLGIFPNVILDSIHVSVSTLLYN","length":484,"molWeight":54268,"crc64":"9C128841C07A5054","md5":"2332A70A48093A3B78713A88FE2C913D"},"extraAttributes":{"countByCommentType":{"FUNCTION":2,"CATALYTIC ACTIVITY":1,"SUBCELLULAR LOCATION":1,"SIMILARITY":1},"countByFeatureType":{"Transmembrane":13,"Domain":1},"uniParcId":"UPI001122CD99"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0A4Y5SK01","uniProtkbId":"A0A4Y5SK01_9AGAM","entryAudit":{"firstPublicDate":"2019-09-18","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2019-09-18","entryVersion":15,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Rhizopogon vinicolor","taxonId":80600,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"QDA23245.1"}],"lineage":["Eukaryota","Fungi","Dikarya","Basidiomycota","Agaricomycotina","Agaricomycetes","Agaricomycetidae","Boletales","Suillineae","Rhizopogonaceae","Rhizopogon"]},"proteinExistence":"3: Inferred from homology","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00012417"}],"value":"DNA-directed DNA polymerase"},"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00012417"}],"value":"2.7.7.7"}]}},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"QDA23245.1"}],"value":"orf201"}}],"comments":[{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:22508"},{"database":"Rhea","id":"RHEA-COMP:17339"},{"database":"Rhea","id":"RHEA-COMP:17340"},{"database":"ChEBI","id":"CHEBI:33019"},{"database":"ChEBI","id":"CHEBI:61560"},{"database":"ChEBI","id":"CHEBI:173112"}],"ecNumber":"2.7.7.7","evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00049244"}]}},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00005755"}],"value":"Belongs to the DNA polymerase type-B family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Domain","location":{"start":{"value":2,"modifier":"EXACT"},"end":{"value":138,"modifier":"EXACT"}},"description":"DNA-directed DNA polymerase family B mitochondria/virus","evidences":[{"evidenceCode":"ECO:0000259","source":"Pfam","id":"PF03175"}]}],"geneLocations":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"QDA23245.1"}],"geneEncodingType":"Mitochondrion"}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022705"}],"id":"KW-0235","category":"Biological process","name":"DNA replication"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023125"}],"id":"KW-0238","category":"Molecular function","name":"DNA-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022932"}],"id":"KW-0239","category":"Molecular function","name":"DNA-directed DNA polymerase"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"QDA23245.1"}],"id":"KW-0496","category":"Cellular component","name":"Mitochondrion"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022695"}],"id":"KW-0548","category":"Molecular function","name":"Nucleotidyltransferase"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022679"}],"id":"KW-0808","category":"Molecular function","name":"Transferase"}],"references":[{"referenceNumber":1,"citation":{"id":"31635252","citationType":"journal article","authors":["Li Q.","Ren Y.","Shi X.","Peng L.","Zhao J.","Song Y.","Zhao G."],"citationCrossReferences":[{"database":"PubMed","id":"31635252"}],"title":"Comparative Mitochondrial Genome Analysis of Two Ectomycorrhizal Fungi (Rhizopogon) Reveals Dynamic Changes of Intron and Phylogenetic Relationships of the Subphylum Agaricomycotina.","publicationDate":"0","journal":"Int. J. Mol. Sci.","firstPage":"0","lastPage":"0","volume":"20"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"QDA23245.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"MH794153","properties":[{"key":"ProteinId","value":"QDA23245.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"RefSeq","id":"YP_009649330.1","properties":[{"key":"NucleotideSequenceId","value":"NC_042699.1"}]},{"database":"AlphaFoldDB","id":"A0A4Y5SK01","properties":[{"key":"Description","value":"-"}]},{"database":"GeneID","id":"40487018","properties":[{"key":"Description","value":"-"}]},{"database":"GO","id":"GO:0003677","properties":[{"key":"GoTerm","value":"F:DNA binding"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0003887","properties":[{"key":"GoTerm","value":"F:DNA-directed DNA polymerase activity"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-EC"}]},{"database":"GO","id":"GO:0000166","properties":[{"key":"GoTerm","value":"F:nucleotide binding"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0006260","properties":[{"key":"GoTerm","value":"P:DNA replication"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"Gene3D","id":"3.90.1600.10","properties":[{"key":"EntryName","value":"Palm domain of DNA polymerase"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR004868","properties":[{"key":"EntryName","value":"DNA-dir_DNA_pol_B_mt/vir"}]},{"database":"InterPro","id":"IPR043502","properties":[{"key":"EntryName","value":"DNA/RNA_pol_sf"}]},{"database":"InterPro","id":"IPR023211","properties":[{"key":"EntryName","value":"DNA_pol_palm_dom_sf"}]},{"database":"PANTHER","id":"PTHR33568","properties":[{"key":"EntryName","value":"DNA POLYMERASE"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR33568:SF3","properties":[{"key":"EntryName","value":"DNA-DIRECTED DNA POLYMERASE"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF03175","properties":[{"key":"EntryName","value":"DNA_pol_B_2"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF56672","properties":[{"key":"EntryName","value":"DNA/RNA polymerases"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MKYWYKFEILRGYTFDKANIFKNYITDLYEIKQSHSKDDPMYLISKLLMNSLYGRFGMNEILYNHEITEDSKLNNYIDKYSINEIISLNNNKSLISYFDNNIKDNIILNNETFSNISISIASAITAYSRIHKTQFKNNPDFELFYTETDSIDIDTPLQDKFIGKELGLMKLEYNFIEATFLAHKVYGGLYFDKNNELKVYN","length":201,"molWeight":23797,"crc64":"8EED2C46D352C394","md5":"D33787EB206E66FF89682F72AC313D9B"},"extraAttributes":{"countByCommentType":{"CATALYTIC ACTIVITY":1,"SIMILARITY":1},"countByFeatureType":{"Domain":1},"uniParcId":"UPI0011244C1A"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0A4Y5SK12","uniProtkbId":"A0A4Y5SK12_9AGAM","entryAudit":{"firstPublicDate":"2019-09-18","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2019-09-18","entryVersion":23,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Rhizopogon vinicolor","taxonId":80600,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"QDA23255.1"}],"lineage":["Eukaryota","Fungi","Dikarya","Basidiomycota","Agaricomycotina","Agaricomycetes","Agaricomycetidae","Boletales","Suillineae","Rhizopogonaceae","Rhizopogon"]},"proteinExistence":"3: Inferred from homology","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00021007"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003640"}],"value":"NADH-ubiquinone oxidoreductase chain 3"},"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003640"}],"value":"7.1.1.2"}]}},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"QDA23255.1"}],"value":"nad3"}}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003640"}],"value":"Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity of complex I"}],"commentType":"FUNCTION"},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"a ubiquinone + NADH + 5 H(+)(in) = a ubiquinol + NAD(+) + 4 H(+)(out)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:29091"},{"database":"Rhea","id":"RHEA-COMP:9565"},{"database":"Rhea","id":"RHEA-COMP:9566"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:16389"},{"database":"ChEBI","id":"CHEBI:17976"},{"database":"ChEBI","id":"CHEBI:57540"},{"database":"ChEBI","id":"CHEBI:57945"}],"ecNumber":"7.1.1.2","evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00049551"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003640"}]}},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004370"}],"value":"Membrane","id":"SL-0162"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003640"}],"value":"Mitochondrion membrane","id":"SL-0171"},"topology":{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003640"}],"value":"Multi-pass membrane protein","id":"SL-9909"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00008472"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003640"}],"value":"Belongs to the complex I subunit 3 family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Transmembrane","location":{"start":{"value":6,"modifier":"EXACT"},"end":{"value":25,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003640"}]},{"type":"Transmembrane","location":{"start":{"value":57,"modifier":"EXACT"},"end":{"value":78,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003640"}]},{"type":"Transmembrane","location":{"start":{"value":84,"modifier":"EXACT"},"end":{"value":105,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003640"}]}],"geneLocations":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"QDA23255.1"}],"geneEncodingType":"Mitochondrion"}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003640"}],"id":"KW-0249","category":"Biological process","name":"Electron transport"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023136"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003640"}],"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003640"},{"evidenceCode":"ECO:0000313","source":"EMBL","id":"QDA23255.1"}],"id":"KW-0496","category":"Cellular component","name":"Mitochondrion"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003640"}],"id":"KW-0520","category":"Ligand","name":"NAD"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003640"}],"id":"KW-0679","category":"Biological process","name":"Respiratory chain"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003640"}],"id":"KW-1278","category":"Molecular function","name":"Translocase"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022692"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003640"}],"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022989"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003640"}],"id":"KW-1133","category":"Domain","name":"Transmembrane helix"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022448"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003640"}],"id":"KW-0813","category":"Biological process","name":"Transport"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003640"}],"id":"KW-0830","category":"Ligand","name":"Ubiquinone"}],"references":[{"referenceNumber":1,"citation":{"id":"31635252","citationType":"journal article","authors":["Li Q.","Ren Y.","Shi X.","Peng L.","Zhao J.","Song Y.","Zhao G."],"citationCrossReferences":[{"database":"PubMed","id":"31635252"}],"title":"Comparative Mitochondrial Genome Analysis of Two Ectomycorrhizal Fungi (Rhizopogon) Reveals Dynamic Changes of Intron and Phylogenetic Relationships of the Subphylum Agaricomycotina.","publicationDate":"0","journal":"Int. J. Mol. Sci.","firstPage":"0","lastPage":"0","volume":"20"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"QDA23255.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"MH794153","properties":[{"key":"ProteinId","value":"QDA23255.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"RefSeq","id":"YP_009649340.1","properties":[{"key":"NucleotideSequenceId","value":"NC_042699.1"}]},{"database":"AlphaFoldDB","id":"A0A4Y5SK12","properties":[{"key":"Description","value":"-"}]},{"database":"GeneID","id":"40487031","properties":[{"key":"Description","value":"-"}]},{"database":"GO","id":"GO:0031966","properties":[{"key":"GoTerm","value":"C:mitochondrial membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0030964","properties":[{"key":"GoTerm","value":"C:NADH dehydrogenase complex"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:0008137","properties":[{"key":"GoTerm","value":"F:NADH dehydrogenase (ubiquinone) activity"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniRule"}]},{"database":"Gene3D","id":"1.20.58.1610","properties":[{"key":"EntryName","value":"NADH:ubiquinone/plastoquinone oxidoreductase, chain 3"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR000440","properties":[{"key":"EntryName","value":"NADH_UbQ/plastoQ_OxRdtase_su3"}]},{"database":"InterPro","id":"IPR038430","properties":[{"key":"EntryName","value":"NDAH_ubi_oxred_su3_sf"}]},{"database":"PANTHER","id":"PTHR11058","properties":[{"key":"EntryName","value":"NADH-UBIQUINONE OXIDOREDUCTASE CHAIN 3"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR11058:SF9","properties":[{"key":"EntryName","value":"NADH-UBIQUINONE OXIDOREDUCTASE CHAIN 3"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00507","properties":[{"key":"EntryName","value":"Oxidored_q4"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MNNLLMLFILVPIVAFALLALNVLLAPRNPYESKVSAYECGFLAIEGQTRSTFQIHFYIVAMLFLVFDLEILLLFPLAVTLYQVSTYGFIIALVFFLVLTIGFVLEIGSGAISLTNYERPLSNEK","length":125,"molWeight":14016,"crc64":"C61F1A6E4CFAC695","md5":"E2B6C10872D7E84C3DA5897663C60917"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"CATALYTIC ACTIVITY":1,"SUBCELLULAR LOCATION":1,"SIMILARITY":1},"countByFeatureType":{"Transmembrane":3},"uniParcId":"UPI00111DD2C0"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0A4Y5SK22","uniProtkbId":"A0A4Y5SK22_9AGAM","entryAudit":{"firstPublicDate":"2019-09-18","lastAnnotationUpdateDate":"2026-11-04","lastSequenceUpdateDate":"2019-09-18","entryVersion":28,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Rhizopogon vinicolor","taxonId":80600,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"QDA23265.1"}],"lineage":["Eukaryota","Fungi","Dikarya","Basidiomycota","Agaricomycotina","Agaricomycetes","Agaricomycetidae","Boletales","Suillineae","Rhizopogonaceae","Rhizopogon"]},"proteinExistence":"3: Inferred from homology","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00021096"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003404"}],"value":"NADH-ubiquinone oxidoreductase chain 5"},"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00012944"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003404"}],"value":"7.1.1.2"}]}},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"QDA23265.1"}],"value":"nad5"}}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00003257"}],"value":"Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003404"}],"value":"Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I"}],"commentType":"FUNCTION"},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"a ubiquinone + NADH + 5 H(+)(in) = a ubiquinol + NAD(+) + 4 H(+)(out)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:29091"},{"database":"Rhea","id":"RHEA-COMP:9565"},{"database":"Rhea","id":"RHEA-COMP:9566"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:16389"},{"database":"ChEBI","id":"CHEBI:17976"},{"database":"ChEBI","id":"CHEBI:57540"},{"database":"ChEBI","id":"CHEBI:57945"}],"ecNumber":"7.1.1.2","evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00049551"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003404"}]}},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004448"}],"value":"Mitochondrion inner membrane","id":"SL-0168"},"topology":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004448"}],"value":"Multi-pass membrane protein","id":"SL-9909"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003404"}],"value":"Belongs to the complex I subunit 5 family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Transmembrane","location":{"start":{"value":6,"modifier":"EXACT"},"end":{"value":24,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003404"}]},{"type":"Transmembrane","location":{"start":{"value":36,"modifier":"EXACT"},"end":{"value":61,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003404"}]},{"type":"Transmembrane","location":{"start":{"value":81,"modifier":"EXACT"},"end":{"value":101,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003404"}]},{"type":"Transmembrane","location":{"start":{"value":113,"modifier":"EXACT"},"end":{"value":131,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003404"}]},{"type":"Transmembrane","location":{"start":{"value":137,"modifier":"EXACT"},"end":{"value":155,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003404"}]},{"type":"Transmembrane","location":{"start":{"value":176,"modifier":"EXACT"},"end":{"value":197,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003404"}]},{"type":"Transmembrane","location":{"start":{"value":203,"modifier":"EXACT"},"end":{"value":222,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003404"}]},{"type":"Transmembrane","location":{"start":{"value":243,"modifier":"EXACT"},"end":{"value":261,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003404"}]},{"type":"Transmembrane","location":{"start":{"value":273,"modifier":"EXACT"},"end":{"value":294,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003404"}]},{"type":"Transmembrane","location":{"start":{"value":301,"modifier":"EXACT"},"end":{"value":321,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003404"}]},{"type":"Transmembrane","location":{"start":{"value":333,"modifier":"EXACT"},"end":{"value":351,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003404"}]},{"type":"Transmembrane","location":{"start":{"value":363,"modifier":"EXACT"},"end":{"value":388,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003404"}]},{"type":"Transmembrane","location":{"start":{"value":408,"modifier":"EXACT"},"end":{"value":440,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003404"}]},{"type":"Transmembrane","location":{"start":{"value":452,"modifier":"EXACT"},"end":{"value":472,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003404"}]},{"type":"Transmembrane","location":{"start":{"value":506,"modifier":"EXACT"},"end":{"value":527,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003404"}]},{"type":"Transmembrane","location":{"start":{"value":614,"modifier":"EXACT"},"end":{"value":635,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003404"}]},{"type":"Transmembrane","location":{"start":{"value":641,"modifier":"EXACT"},"end":{"value":661,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003404"}]},{"type":"Domain","location":{"start":{"value":64,"modifier":"EXACT"},"end":{"value":114,"modifier":"EXACT"}},"description":"NADH-Ubiquinone oxidoreductase (complex I) chain 5 N-terminal","evidences":[{"evidenceCode":"ECO:0000259","source":"Pfam","id":"PF00662"}]},{"type":"Domain","location":{"start":{"value":132,"modifier":"EXACT"},"end":{"value":414,"modifier":"EXACT"}},"description":"NADH:quinone oxidoreductase/Mrp antiporter transmembrane","evidences":[{"evidenceCode":"ECO:0000259","source":"Pfam","id":"PF00361"}]},{"type":"Domain","location":{"start":{"value":424,"modifier":"EXACT"},"end":{"value":627,"modifier":"EXACT"}},"description":"NADH dehydrogenase subunit 5 C-terminal","evidences":[{"evidenceCode":"ECO:0000259","source":"Pfam","id":"PF06455"}]}],"geneLocations":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"QDA23265.1"}],"geneEncodingType":"Mitochondrion"}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022982"}],"id":"KW-0249","category":"Biological process","name":"Electron transport"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023136"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003404"}],"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023128"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003404"}],"id":"KW-0496","category":"Cellular component","name":"Mitochondrion"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022792"}],"id":"KW-0999","category":"Cellular component","name":"Mitochondrion inner membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023027"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003404"}],"id":"KW-0520","category":"Ligand","name":"NAD"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022660"}],"id":"KW-0679","category":"Biological process","name":"Respiratory chain"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022967"}],"id":"KW-1278","category":"Molecular function","name":"Translocase"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022692"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003404"}],"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022989"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003404"}],"id":"KW-1133","category":"Domain","name":"Transmembrane helix"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022448"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003404"}],"id":"KW-0813","category":"Biological process","name":"Transport"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023075"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003404"}],"id":"KW-0830","category":"Ligand","name":"Ubiquinone"}],"references":[{"referenceNumber":1,"citation":{"id":"31635252","citationType":"journal article","authors":["Li Q.","Ren Y.","Shi X.","Peng L.","Zhao J.","Song Y.","Zhao G."],"citationCrossReferences":[{"database":"PubMed","id":"31635252"}],"title":"Comparative Mitochondrial Genome Analysis of Two Ectomycorrhizal Fungi (Rhizopogon) Reveals Dynamic Changes of Intron and Phylogenetic Relationships of the Subphylum Agaricomycotina.","publicationDate":"0","journal":"Int. J. Mol. Sci.","firstPage":"0","lastPage":"0","volume":"20"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"QDA23265.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"MH794153","properties":[{"key":"ProteinId","value":"QDA23265.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"RefSeq","id":"YP_009649348.1","properties":[{"key":"NucleotideSequenceId","value":"NC_042699.1"}]},{"database":"AlphaFoldDB","id":"A0A4Y5SK22","properties":[{"key":"Description","value":"-"}]},{"database":"GeneID","id":"40487049","properties":[{"key":"Description","value":"-"}]},{"database":"GO","id":"GO:0005743","properties":[{"key":"GoTerm","value":"C:mitochondrial inner membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0008137","properties":[{"key":"GoTerm","value":"F:NADH dehydrogenase (ubiquinone) activity"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-EC"}]},{"database":"GO","id":"GO:0042773","properties":[{"key":"GoTerm","value":"P:ATP synthesis coupled electron transport"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0015990","properties":[{"key":"GoTerm","value":"P:electron transport coupled proton transport"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"Gene3D","id":"1.20.5.2700","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR010934","properties":[{"key":"EntryName","value":"NADH_DH_su5_C"}]},{"database":"InterPro","id":"IPR018393","properties":[{"key":"EntryName","value":"NADHpl_OxRdtase_5_subgr"}]},{"database":"InterPro","id":"IPR001750","properties":[{"key":"EntryName","value":"ND/Mrp_TM"}]},{"database":"InterPro","id":"IPR003945","properties":[{"key":"EntryName","value":"NU5C-like"}]},{"database":"InterPro","id":"IPR001516","properties":[{"key":"EntryName","value":"Proton_antipo_N"}]},{"database":"NCBIfam","id":"TIGR01974","properties":[{"key":"EntryName","value":"NDH_I_L"},{"key":"MatchStatus","value":"1"}]},{"database":"NCBIfam","id":"NF005141","properties":[{"key":"EntryName","value":"nuoL"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR42829","properties":[{"key":"EntryName","value":"NADH-UBIQUINONE OXIDOREDUCTASE CHAIN 5"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR42829:SF2","properties":[{"key":"EntryName","value":"NADH-UBIQUINONE OXIDOREDUCTASE CHAIN 5"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF06455","properties":[{"key":"EntryName","value":"NADH5_C"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00361","properties":[{"key":"EntryName","value":"Proton_antipo_M"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00662","properties":[{"key":"EntryName","value":"Proton_antipo_N"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR01434","properties":[{"key":"EntryName","value":"NADHDHGNASE5"}]},{"database":"PRINTS","id":"PR01435","properties":[{"key":"EntryName","value":"NPOXDRDTASE5"}]}],"sequence":{"value":"MYLSILIFPLLASFVSGFLGRKIGVTGSHIITCSSLVISSLLATVAFYEVGICGSPVSIHLFSWVDSEFMSISWEFLFDQLTVSMFIPVLYISTLIHIYTTSYLAEDPHNQRFFSYLSLFTFFMLLLVSGANYFVMFIGWEGIGVVSYLLINYYYTRIQANKAAILALTMNRVGDMGLSIGFFAIFALFGSVDYATIFSLAPFMNETAITIISLLLLMGAMAKSAQIPLHSWLPGSMEAPTPVSALLHAATLVTAGLYLLVRSSPVLEYSSTALLIITLVGATTAFFAATCGLVQNDLKRIIAFSTISQLGYMVMAVGLSQHNVALMHVVNHAFFKALLFLGAGAVIHSFADEQDVRKMGGLIKFLPFTYTAMLVGSLSLLATPWLSGFYSKDLIIELAYGQYSFTGIYAYILGSLTAGLTAFYSFRLISLVFLTVPNGIKNVYLNSHESNLAVIIPLFVLALFSIFFGFVFSDLFVGVGSDFFGNSIFINPNNISIIEAEFSLPLLIKLLPSILSLFGASLAIYLYHVNPEFVINLTDSSLGRNIYTFLNGKYFFDVIYNHYFIAASLKTGYTISKVLDRGVIELLGPYGLASALSNTAINIAKLDTGVITTYSLYITLGLLSLVFLVFAPILIDTSLLSEIRLIIIYIAALFFVLLPNLNKTL","length":665,"molWeight":72963,"crc64":"56130CCEC213801E","md5":"6A584181EBFBF6CE785CCED98FE7813F"},"extraAttributes":{"countByCommentType":{"FUNCTION":2,"CATALYTIC ACTIVITY":1,"SUBCELLULAR LOCATION":1,"SIMILARITY":1},"countByFeatureType":{"Transmembrane":17,"Domain":3},"uniParcId":"UPI001120336D"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0A4Y5SHS8","uniProtkbId":"A0A4Y5SHS8_9AGAM","entryAudit":{"firstPublicDate":"2019-09-18","lastAnnotationUpdateDate":"2026-11-04","lastSequenceUpdateDate":"2019-09-18","entryVersion":15,"sequenceVersion":1},"annotationScore":1.0,"organism":{"scientificName":"Rhizopogon vinicolor","taxonId":80600,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"QDA23228.1"}],"lineage":["Eukaryota","Fungi","Dikarya","Basidiomycota","Agaricomycotina","Agaricomycetes","Agaricomycetidae","Boletales","Suillineae","Rhizopogonaceae","Rhizopogon"]},"proteinExistence":"4: Predicted","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"QDA23228.1"}],"value":"LAGLIDADG type 1 homing endonuclease"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"QDA23228.1"}],"value":"orf380"}}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00002670"}],"value":"Mitochondrial DNA endonuclease involved in intron homing"}],"commentType":"FUNCTION"}],"features":[{"type":"Domain","location":{"start":{"value":106,"modifier":"EXACT"},"end":{"value":200,"modifier":"EXACT"}},"description":"Homing endonuclease LAGLIDADG","evidences":[{"evidenceCode":"ECO:0000259","source":"Pfam","id":"PF00961"}]},{"type":"Domain","location":{"start":{"value":256,"modifier":"EXACT"},"end":{"value":345,"modifier":"EXACT"}},"description":"Homing endonuclease LAGLIDADG","evidences":[{"evidenceCode":"ECO:0000259","source":"Pfam","id":"PF00961"}]}],"geneLocations":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"QDA23228.1"}],"geneEncodingType":"Mitochondrion"}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"QDA23228.1"}],"id":"KW-0255","category":"Molecular function","name":"Endonuclease"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"QDA23228.1"}],"id":"KW-0378","category":"Molecular function","name":"Hydrolase"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"QDA23228.1"}],"id":"KW-0496","category":"Cellular component","name":"Mitochondrion"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"QDA23228.1"}],"id":"KW-0540","category":"Molecular function","name":"Nuclease"}],"references":[{"referenceNumber":1,"citation":{"id":"31635252","citationType":"journal article","authors":["Li Q.","Ren Y.","Shi X.","Peng L.","Zhao J.","Song Y.","Zhao G."],"citationCrossReferences":[{"database":"PubMed","id":"31635252"}],"title":"Comparative Mitochondrial Genome Analysis of Two Ectomycorrhizal Fungi (Rhizopogon) Reveals Dynamic Changes of Intron and Phylogenetic Relationships of the Subphylum Agaricomycotina.","publicationDate":"0","journal":"Int. J. Mol. Sci.","firstPage":"0","lastPage":"0","volume":"20"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"QDA23228.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"MH794153","properties":[{"key":"ProteinId","value":"QDA23228.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"RefSeq","id":"YP_009649314.1","properties":[{"key":"NucleotideSequenceId","value":"NC_042699.1"}]},{"database":"AlphaFoldDB","id":"A0A4Y5SHS8","properties":[{"key":"Description","value":"-"}]},{"database":"GeneID","id":"40486993","properties":[{"key":"Description","value":"-"}]},{"database":"GO","id":"GO:0005739","properties":[{"key":"GoTerm","value":"C:mitochondrion"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0004519","properties":[{"key":"GoTerm","value":"F:endonuclease activity"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"Gene3D","id":"3.10.28.10","properties":[{"key":"EntryName","value":"Homing endonucleases"},{"key":"MatchStatus","value":"2"}]},{"database":"InterPro","id":"IPR027434","properties":[{"key":"EntryName","value":"Homing_endonucl"}]},{"database":"InterPro","id":"IPR004860","properties":[{"key":"EntryName","value":"LAGLIDADG_dom"}]},{"database":"PANTHER","id":"PTHR36181","properties":[{"key":"EntryName","value":"INTRON-ENCODED ENDONUCLEASE AI3-RELATED"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR36181:SF2","properties":[{"key":"EntryName","value":"INTRON-ENCODED ENDONUCLEASE AI3-RELATED"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00961","properties":[{"key":"EntryName","value":"LAGLIDADG_1"},{"key":"MatchStatus","value":"2"}]},{"database":"SUPFAM","id":"SSF55608","properties":[{"key":"EntryName","value":"Homing endonucleases"},{"key":"MatchStatus","value":"2"}]}],"sequence":{"value":"MVSLLLIFIELVNLDKLSYYSDIVLLNLTRCEDILLLIKVNNCLSFDLNVRKKVIDLKIIRLNKIITQYFIIHQRLNVRYLISKFSMLNINKNSLSENKDIFYQWLVGFTDAEGTFSIDRQNNNWSLIFQIGQSNYNLRVLHFIKKQLGVGNIIVEKNNNLAQFRIRDRSVLELIIFPIFDKYPLLTSKYFYYIKFKKAHAILSDKSLTKPEKDILIFNLIKTNPPLDYISPAWSIINNIVSNYENASKIISKSWLVGFTEAEGSFYLVNKSKNRIVHAFEITQKLDKIVLIGIKHILHISTKVQFKNAGYFTIVTTNSRAIENIIQYYNNTMKGMKSVEYRIWARSYVKDKGNFISLNKIRNQIRIMKQVKYNLIDMKI","length":380,"molWeight":44624,"crc64":"5338617991EC6351","md5":"BB59630DCCA83CB71D301B1073CE2698"},"extraAttributes":{"countByCommentType":{"FUNCTION":1},"countByFeatureType":{"Domain":2},"uniParcId":"UPI00111DC690"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0A4Y5SHT0","uniProtkbId":"A0A4Y5SHT0_9AGAM","entryAudit":{"firstPublicDate":"2019-09-18","lastAnnotationUpdateDate":"2026-11-04","lastSequenceUpdateDate":"2019-09-18","entryVersion":17,"sequenceVersion":1},"annotationScore":1.0,"organism":{"scientificName":"Rhizopogon vinicolor","taxonId":80600,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"QDA23231.1"}],"lineage":["Eukaryota","Fungi","Dikarya","Basidiomycota","Agaricomycotina","Agaricomycetes","Agaricomycetidae","Boletales","Suillineae","Rhizopogonaceae","Rhizopogon"]},"proteinExistence":"4: Predicted","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"QDA23231.1"}],"value":"LAGLIDADG endonuclease"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"QDA23231.1"}],"value":"orf295"}}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00002670"}],"value":"Mitochondrial DNA endonuclease involved in intron homing"}],"commentType":"FUNCTION"}],"features":[{"type":"Domain","location":{"start":{"value":63,"modifier":"EXACT"},"end":{"value":148,"modifier":"EXACT"}},"description":"Homing endonuclease LAGLIDADG","evidences":[{"evidenceCode":"ECO:0000259","source":"Pfam","id":"PF00961"}]},{"type":"Domain","location":{"start":{"value":170,"modifier":"EXACT"},"end":{"value":262,"modifier":"EXACT"}},"description":"Homing endonuclease LAGLIDADG","evidences":[{"evidenceCode":"ECO:0000259","source":"Pfam","id":"PF00961"}]}],"geneLocations":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"QDA23231.1"}],"geneEncodingType":"Mitochondrion"}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"QDA23231.1"}],"id":"KW-0255","category":"Molecular function","name":"Endonuclease"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"QDA23231.1"}],"id":"KW-0378","category":"Molecular function","name":"Hydrolase"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"QDA23231.1"}],"id":"KW-0496","category":"Cellular component","name":"Mitochondrion"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"QDA23231.1"}],"id":"KW-0540","category":"Molecular function","name":"Nuclease"}],"references":[{"referenceNumber":1,"citation":{"id":"31635252","citationType":"journal article","authors":["Li Q.","Ren Y.","Shi X.","Peng L.","Zhao J.","Song Y.","Zhao G."],"citationCrossReferences":[{"database":"PubMed","id":"31635252"}],"title":"Comparative Mitochondrial Genome Analysis of Two Ectomycorrhizal Fungi (Rhizopogon) Reveals Dynamic Changes of Intron and Phylogenetic Relationships of the Subphylum Agaricomycotina.","publicationDate":"0","journal":"Int. J. Mol. Sci.","firstPage":"0","lastPage":"0","volume":"20"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"QDA23231.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"MH794153","properties":[{"key":"ProteinId","value":"QDA23231.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"RefSeq","id":"YP_009649317.1","properties":[{"key":"NucleotideSequenceId","value":"NC_042699.1"}]},{"database":"AlphaFoldDB","id":"A0A4Y5SHT0","properties":[{"key":"Description","value":"-"}]},{"database":"GeneID","id":"40486996","properties":[{"key":"Description","value":"-"}]},{"database":"GO","id":"GO:0004519","properties":[{"key":"GoTerm","value":"F:endonuclease activity"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"Gene3D","id":"3.10.28.10","properties":[{"key":"EntryName","value":"Homing endonucleases"},{"key":"MatchStatus","value":"2"}]},{"database":"InterPro","id":"IPR027434","properties":[{"key":"EntryName","value":"Homing_endonucl"}]},{"database":"InterPro","id":"IPR004860","properties":[{"key":"EntryName","value":"LAGLIDADG_dom"}]},{"database":"PANTHER","id":"PTHR37520","properties":[{"key":"EntryName","value":"INTRON-ENCODED DNA ENDONUCLEASE AI2A-RELATED"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR37520:SF1","properties":[{"key":"EntryName","value":"INTRON-ENCODED DNA ENDONUCLEASE AI2A-RELATED"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00961","properties":[{"key":"EntryName","value":"LAGLIDADG_1"},{"key":"MatchStatus","value":"2"}]},{"database":"SUPFAM","id":"SSF55608","properties":[{"key":"EntryName","value":"Homing endonucleases"},{"key":"MatchStatus","value":"2"}]}],"sequence":{"value":"MYLGTNIISLIIVLAILVKVTELYIRNQPVTKSRRYSSYLVGTSETTRVISLDKKEIRFNQWLAGLIDGDGCLLLSKLGYTSCEITVSLADERILRIIQNKLGGSIKIRSGVKTLRWRLHNRTGMINLINRINGYIRHSGRFIQLSHVCAALNIQLLNSDTLHKKHGWFSGFFDADGTINYYFKGKYNYPQLTLNVTNKLLVDVIHFKNYFGGEIYFDKSHNGYYKWSIQSQDLINSFVEYTHICPVQSIKRNRLFLVKEYYRLISLEAYKALEGTILNKTWNKFNLKWNKPNLS","length":295,"molWeight":34235,"crc64":"D354D1DDEFA618F5","md5":"628012F90D36F0CF5EA3E2DF2F6B976C"},"extraAttributes":{"countByCommentType":{"FUNCTION":1},"countByFeatureType":{"Domain":2},"uniParcId":"UPI0011209E4C"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0A4Y5SHT2","uniProtkbId":"A0A4Y5SHT2_9AGAM","entryAudit":{"firstPublicDate":"2019-09-18","lastAnnotationUpdateDate":"2026-11-04","lastSequenceUpdateDate":"2019-09-18","entryVersion":16,"sequenceVersion":1},"annotationScore":1.0,"organism":{"scientificName":"Rhizopogon vinicolor","taxonId":80600,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"QDA23233.1"}],"lineage":["Eukaryota","Fungi","Dikarya","Basidiomycota","Agaricomycotina","Agaricomycetes","Agaricomycetidae","Boletales","Suillineae","Rhizopogonaceae","Rhizopogon"]},"proteinExistence":"4: Predicted","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"QDA23233.1"}],"value":"LAGLIDADG type 1 homing endonuclease"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"QDA23233.1"}],"value":"orf110"}}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00002670"}],"value":"Mitochondrial DNA endonuclease involved in intron homing"}],"commentType":"FUNCTION"}],"features":[{"type":"Domain","location":{"start":{"value":39,"modifier":"EXACT"},"end":{"value":105,"modifier":"EXACT"}},"description":"Homing endonuclease LAGLIDADG","evidences":[{"evidenceCode":"ECO:0000259","source":"Pfam","id":"PF00961"}]}],"geneLocations":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"QDA23233.1"}],"geneEncodingType":"Mitochondrion"}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"QDA23233.1"}],"id":"KW-0255","category":"Molecular function","name":"Endonuclease"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"QDA23233.1"}],"id":"KW-0378","category":"Molecular function","name":"Hydrolase"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"QDA23233.1"}],"id":"KW-0496","category":"Cellular component","name":"Mitochondrion"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"QDA23233.1"}],"id":"KW-0540","category":"Molecular function","name":"Nuclease"}],"references":[{"referenceNumber":1,"citation":{"id":"31635252","citationType":"journal article","authors":["Li Q.","Ren Y.","Shi X.","Peng L.","Zhao J.","Song Y.","Zhao G."],"citationCrossReferences":[{"database":"PubMed","id":"31635252"}],"title":"Comparative Mitochondrial Genome Analysis of Two Ectomycorrhizal Fungi (Rhizopogon) Reveals Dynamic Changes of Intron and Phylogenetic Relationships of the Subphylum Agaricomycotina.","publicationDate":"0","journal":"Int. J. Mol. Sci.","firstPage":"0","lastPage":"0","volume":"20"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"QDA23233.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"MH794153","properties":[{"key":"ProteinId","value":"QDA23233.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"RefSeq","id":"YP_009649319.1","properties":[{"key":"NucleotideSequenceId","value":"NC_042699.1"}]},{"database":"AlphaFoldDB","id":"A0A4Y5SHT2","properties":[{"key":"Description","value":"-"}]},{"database":"GeneID","id":"40486998","properties":[{"key":"Description","value":"-"}]},{"database":"GO","id":"GO:0005739","properties":[{"key":"GoTerm","value":"C:mitochondrion"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0004519","properties":[{"key":"GoTerm","value":"F:endonuclease activity"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"Gene3D","id":"3.10.28.10","properties":[{"key":"EntryName","value":"Homing endonucleases"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR027434","properties":[{"key":"EntryName","value":"Homing_endonucl"}]},{"database":"InterPro","id":"IPR004860","properties":[{"key":"EntryName","value":"LAGLIDADG_dom"}]},{"database":"PANTHER","id":"PTHR36181","properties":[{"key":"EntryName","value":"INTRON-ENCODED ENDONUCLEASE AI3-RELATED"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR36181:SF4","properties":[{"key":"EntryName","value":"LAGLIDADG ENDONUCLEASE"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00961","properties":[{"key":"EntryName","value":"LAGLIDADG_1"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF55608","properties":[{"key":"EntryName","value":"Homing endonucleases"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MSYVNSIIVKYKNKVAFSEKRIFSNNTKIFNKIESNWVTGFCEAEGCFSVIVTRRSNLNWRTIVSFEINLHIKDIEILYQIKEFFDVGLVTIRPKKFKCVYRVTKNWRFI","length":110,"molWeight":13154,"crc64":"EDDB4E88F2FD2C0D","md5":"6DE160F0B6552ECC82C3108CB2344075"},"extraAttributes":{"countByCommentType":{"FUNCTION":1},"countByFeatureType":{"Domain":1},"uniParcId":"UPI001120F991"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0A4Y5SHT8","uniProtkbId":"A0A4Y5SHT8_9AGAM","entryAudit":{"firstPublicDate":"2019-09-18","lastAnnotationUpdateDate":"2026-11-04","lastSequenceUpdateDate":"2019-09-18","entryVersion":14,"sequenceVersion":1},"annotationScore":1.0,"organism":{"scientificName":"Rhizopogon vinicolor","taxonId":80600,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"QDA23238.1"}],"lineage":["Eukaryota","Fungi","Dikarya","Basidiomycota","Agaricomycotina","Agaricomycetes","Agaricomycetidae","Boletales","Suillineae","Rhizopogonaceae","Rhizopogon"]},"proteinExistence":"4: Predicted","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"QDA23238.1"}],"value":"GIY-YIG endonuclease"}}],"flag":"Fragment"},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"QDA23238.1"}],"value":"orf224"}}],"features":[{"type":"Domain","location":{"start":{"value":96,"modifier":"EXACT"},"end":{"value":192,"modifier":"EXACT"}},"description":"GIY-YIG","evidences":[{"evidenceCode":"ECO:0000259","source":"SMART","id":"SM00465"}]},{"type":"Non-terminal residue","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":1,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"QDA23238.1"}]}],"geneLocations":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"QDA23238.1"}],"geneEncodingType":"Mitochondrion"}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"QDA23238.1"}],"id":"KW-0255","category":"Molecular function","name":"Endonuclease"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"QDA23238.1"}],"id":"KW-0378","category":"Molecular function","name":"Hydrolase"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"QDA23238.1"}],"id":"KW-0496","category":"Cellular component","name":"Mitochondrion"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"QDA23238.1"}],"id":"KW-0540","category":"Molecular function","name":"Nuclease"}],"references":[{"referenceNumber":1,"citation":{"id":"31635252","citationType":"journal article","authors":["Li Q.","Ren Y.","Shi X.","Peng L.","Zhao J.","Song Y.","Zhao G."],"citationCrossReferences":[{"database":"PubMed","id":"31635252"}],"title":"Comparative Mitochondrial Genome Analysis of Two Ectomycorrhizal Fungi (Rhizopogon) Reveals Dynamic Changes of Intron and Phylogenetic Relationships of the Subphylum Agaricomycotina.","publicationDate":"0","journal":"Int. J. Mol. Sci.","firstPage":"0","lastPage":"0","volume":"20"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"QDA23238.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"MH794153","properties":[{"key":"ProteinId","value":"QDA23238.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"RefSeq","id":"YP_009649324.1","properties":[{"key":"NucleotideSequenceId","value":"NC_042699.1"}]},{"database":"AlphaFoldDB","id":"A0A4Y5SHT8","properties":[{"key":"Description","value":"-"}]},{"database":"GeneID","id":"40487003","properties":[{"key":"Description","value":"-"}]},{"database":"Gene3D","id":"3.40.1440.10","properties":[{"key":"EntryName","value":"GIY-YIG endonuclease"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR000305","properties":[{"key":"EntryName","value":"GIY-YIG_endonuc"}]},{"database":"InterPro","id":"IPR035901","properties":[{"key":"EntryName","value":"GIY-YIG_endonuc_sf"}]},{"database":"SMART","id":"SM00465","properties":[{"key":"EntryName","value":"GIYc"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF82771","properties":[{"key":"EntryName","value":"GIY-YIG endonuclease"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"KIYFQYFNKAQFNVQHLVINIIMLLYFYLYEDIKILTDSIIFNVIPVSISIKDRQFKIFNFPNGPHIKLQWLNTPIRLYDNPNYLKNLIGYDNKKQSIIYQRVNLITGKIYVGSAWNGSIRLLSYWTPSALRRNFPIYHNINYYGIHNFALAILEDLDTSGSVKKEFILSREQHYLDMLFINFPQLVIILAKIAGSTKGYKHKLEFGLNPSGQLNSMFGRVKSK","length":224,"molWeight":26270,"crc64":"56B32060CB86CE77","md5":"6E27ECAF40DAC7EFF76E0A78B9FE156F"},"extraAttributes":{"countByFeatureType":{"Domain":1,"Non-terminal residue":1},"uniParcId":"UPI00112050DF"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0A4Y5SHT9","uniProtkbId":"A0A4Y5SHT9_9AGAM","entryAudit":{"firstPublicDate":"2019-09-18","lastAnnotationUpdateDate":"2026-01-28","lastSequenceUpdateDate":"2019-09-18","entryVersion":7,"sequenceVersion":1},"annotationScore":1.0,"organism":{"scientificName":"Rhizopogon vinicolor","taxonId":80600,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"QDA23241.1"}],"lineage":["Eukaryota","Fungi","Dikarya","Basidiomycota","Agaricomycotina","Agaricomycetes","Agaricomycetidae","Boletales","Suillineae","Rhizopogonaceae","Rhizopogon"]},"proteinExistence":"4: Predicted","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"QDA23241.1"}],"value":"Uncharacterized protein"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"QDA23241.1"}],"value":"orf105"}}],"geneLocations":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"QDA23241.1"}],"geneEncodingType":"Mitochondrion"}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"QDA23241.1"}],"id":"KW-0496","category":"Cellular component","name":"Mitochondrion"}],"references":[{"referenceNumber":1,"citation":{"id":"31635252","citationType":"journal article","authors":["Li Q.","Ren Y.","Shi X.","Peng L.","Zhao J.","Song Y.","Zhao G."],"citationCrossReferences":[{"database":"PubMed","id":"31635252"}],"title":"Comparative Mitochondrial Genome Analysis of Two Ectomycorrhizal Fungi (Rhizopogon) Reveals Dynamic Changes of Intron and Phylogenetic Relationships of the Subphylum Agaricomycotina.","publicationDate":"0","journal":"Int. J. Mol. Sci.","firstPage":"0","lastPage":"0","volume":"20"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"QDA23241.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"MH794153","properties":[{"key":"ProteinId","value":"QDA23241.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"RefSeq","id":"YP_009649326.1","properties":[{"key":"NucleotideSequenceId","value":"NC_042699.1"}]},{"database":"AlphaFoldDB","id":"A0A4Y5SHT9","properties":[{"key":"Description","value":"-"}]},{"database":"GeneID","id":"40487006","properties":[{"key":"Description","value":"-"}]}],"sequence":{"value":"MIIIKMNNMNKFNQSNLLTPDIWNHYTISYKNKLLTNSRLKHSLLKFLKEITTKIENKMVILLLIIEYSDNTLVTLSNIQKVNYNEFKILFELFKEYINLEKWRL","length":105,"molWeight":12727,"crc64":"32F63810E0B9128B","md5":"886498132F57BE08D99D8118E6721CA6"},"extraAttributes":{"uniParcId":"UPI0011200B30"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0A4Y5SHU0","uniProtkbId":"A0A4Y5SHU0_9AGAM","entryAudit":{"firstPublicDate":"2019-09-18","lastAnnotationUpdateDate":"2026-11-04","lastSequenceUpdateDate":"2019-09-18","entryVersion":17,"sequenceVersion":1},"annotationScore":1.0,"organism":{"scientificName":"Rhizopogon vinicolor","taxonId":80600,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"QDA23232.1"}],"lineage":["Eukaryota","Fungi","Dikarya","Basidiomycota","Agaricomycotina","Agaricomycetes","Agaricomycetidae","Boletales","Suillineae","Rhizopogonaceae","Rhizopogon"]},"proteinExistence":"4: Predicted","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"QDA23232.1"}],"value":"LAGLIDADG type 1 homing endonuclease"}}],"flag":"Fragment"},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"QDA23232.1"}],"value":"orf331"}}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00002670"}],"value":"Mitochondrial DNA endonuclease involved in intron homing"}],"commentType":"FUNCTION"}],"features":[{"type":"Domain","location":{"start":{"value":204,"modifier":"EXACT"},"end":{"value":298,"modifier":"EXACT"}},"description":"Homing endonuclease LAGLIDADG","evidences":[{"evidenceCode":"ECO:0000259","source":"Pfam","id":"PF00961"}]},{"type":"Non-terminal residue","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":1,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"QDA23232.1"}]}],"geneLocations":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"QDA23232.1"}],"geneEncodingType":"Mitochondrion"}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"QDA23232.1"}],"id":"KW-0255","category":"Molecular function","name":"Endonuclease"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"QDA23232.1"}],"id":"KW-0378","category":"Molecular function","name":"Hydrolase"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"QDA23232.1"}],"id":"KW-0496","category":"Cellular component","name":"Mitochondrion"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"QDA23232.1"}],"id":"KW-0540","category":"Molecular function","name":"Nuclease"}],"references":[{"referenceNumber":1,"citation":{"id":"31635252","citationType":"journal article","authors":["Li Q.","Ren Y.","Shi X.","Peng L.","Zhao J.","Song Y.","Zhao G."],"citationCrossReferences":[{"database":"PubMed","id":"31635252"}],"title":"Comparative Mitochondrial Genome Analysis of Two Ectomycorrhizal Fungi (Rhizopogon) Reveals Dynamic Changes of Intron and Phylogenetic Relationships of the Subphylum Agaricomycotina.","publicationDate":"0","journal":"Int. J. Mol. Sci.","firstPage":"0","lastPage":"0","volume":"20"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"QDA23232.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"MH794153","properties":[{"key":"ProteinId","value":"QDA23232.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"RefSeq","id":"YP_009649318.1","properties":[{"key":"NucleotideSequenceId","value":"NC_042699.1"}]},{"database":"AlphaFoldDB","id":"A0A4Y5SHU0","properties":[{"key":"Description","value":"-"}]},{"database":"GeneID","id":"40486997","properties":[{"key":"Description","value":"-"}]},{"database":"GO","id":"GO:0005739","properties":[{"key":"GoTerm","value":"C:mitochondrion"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0004519","properties":[{"key":"GoTerm","value":"F:endonuclease activity"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"Gene3D","id":"3.10.28.10","properties":[{"key":"EntryName","value":"Homing endonucleases"},{"key":"MatchStatus","value":"2"}]},{"database":"InterPro","id":"IPR027434","properties":[{"key":"EntryName","value":"Homing_endonucl"}]},{"database":"InterPro","id":"IPR004860","properties":[{"key":"EntryName","value":"LAGLIDADG_dom"}]},{"database":"PANTHER","id":"PTHR36181:SF3","properties":[{"key":"EntryName","value":"INTRON-ENCODED DNA ENDONUCLEASE AI5 BETA"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR36181","properties":[{"key":"EntryName","value":"INTRON-ENCODED ENDONUCLEASE AI3-RELATED"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00961","properties":[{"key":"EntryName","value":"LAGLIDADG_1"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF55608","properties":[{"key":"EntryName","value":"Homing endonucleases"},{"key":"MatchStatus","value":"2"}]}],"sequence":{"value":"HFINISFLMWLFAGITLVSFKYSHYFKVIVKKLKQRSRSAGNFIKISNELTNNLINKRTSETLRYKSTESVNIKKISIHVPKHFKPINDSDFSYYLAGLIDGDGHFSKVFQLVIVFNELDASLAYFIKGQIGYGNVYKVKNKKAIILVISNRAGLLKILNLINGKIRSENKLNQINNNILSNPYFKSFPVFSLNSDVNLNNYWLSGFSDADASFQIKLITRKNKTEVRLNFQIDQKKKDLLILIKDFLGGNIGYRKSQDTYYYGSASFGSAKNVINYFDYFQLLSSKHINYLKWRKAYIIIQNKKHLTDSGVDEIIKLKKTMNRNNSDTID","length":331,"molWeight":38242,"crc64":"57AE4D05EB756761","md5":"D2476CE5C955C1C293C2447A6841DFDF"},"extraAttributes":{"countByCommentType":{"FUNCTION":1},"countByFeatureType":{"Domain":1,"Non-terminal residue":1},"uniParcId":"UPI00111F5193"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0A4Y5SHU1","uniProtkbId":"A0A4Y5SHU1_9AGAM","entryAudit":{"firstPublicDate":"2019-09-18","lastAnnotationUpdateDate":"2026-11-04","lastSequenceUpdateDate":"2019-09-18","entryVersion":16,"sequenceVersion":1},"annotationScore":1.0,"organism":{"scientificName":"Rhizopogon vinicolor","taxonId":80600,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"QDA23243.1"}],"lineage":["Eukaryota","Fungi","Dikarya","Basidiomycota","Agaricomycotina","Agaricomycetes","Agaricomycetidae","Boletales","Suillineae","Rhizopogonaceae","Rhizopogon"]},"proteinExistence":"3: Inferred from homology","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"QDA23243.1"}],"value":"LAGLIDADG type 2 homing endonuclease"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"QDA23243.1"}],"value":"orf204"}}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00002670"}],"value":"Mitochondrial DNA endonuclease involved in intron homing"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00005588"}],"value":"Belongs to the LAGLIDADG endonuclease family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Domain","location":{"start":{"value":40,"modifier":"EXACT"},"end":{"value":203,"modifier":"EXACT"}},"description":"Homing endonuclease LAGLIDADG","evidences":[{"evidenceCode":"ECO:0000259","source":"Pfam","id":"PF03161"}]}],"geneLocations":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"QDA23243.1"}],"geneEncodingType":"Mitochondrion"}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"QDA23243.1"}],"id":"KW-0255","category":"Molecular function","name":"Endonuclease"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"QDA23243.1"}],"id":"KW-0378","category":"Molecular function","name":"Hydrolase"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"QDA23243.1"}],"id":"KW-0496","category":"Cellular component","name":"Mitochondrion"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"QDA23243.1"}],"id":"KW-0540","category":"Molecular function","name":"Nuclease"}],"references":[{"referenceNumber":1,"citation":{"id":"31635252","citationType":"journal article","authors":["Li Q.","Ren Y.","Shi X.","Peng L.","Zhao J.","Song Y.","Zhao G."],"citationCrossReferences":[{"database":"PubMed","id":"31635252"}],"title":"Comparative Mitochondrial Genome Analysis of Two Ectomycorrhizal Fungi (Rhizopogon) Reveals Dynamic Changes of Intron and Phylogenetic Relationships of the Subphylum Agaricomycotina.","publicationDate":"0","journal":"Int. J. Mol. Sci.","firstPage":"0","lastPage":"0","volume":"20"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"QDA23243.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"MH794153","properties":[{"key":"ProteinId","value":"QDA23243.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"RefSeq","id":"YP_009649328.1","properties":[{"key":"NucleotideSequenceId","value":"NC_042699.1"}]},{"database":"AlphaFoldDB","id":"A0A4Y5SHU1","properties":[{"key":"Description","value":"-"}]},{"database":"GeneID","id":"40487011","properties":[{"key":"Description","value":"-"}]},{"database":"GO","id":"GO:0004519","properties":[{"key":"GoTerm","value":"F:endonuclease activity"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0000373","properties":[{"key":"GoTerm","value":"P:Group II intron splicing"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:0045292","properties":[{"key":"GoTerm","value":"P:mRNA cis splicing, via spliceosome"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"Gene3D","id":"3.10.28.10","properties":[{"key":"EntryName","value":"Homing endonucleases"},{"key":"MatchStatus","value":"2"}]},{"database":"InterPro","id":"IPR052500","properties":[{"key":"EntryName","value":"Chloro/Mito_RNA_Process"}]},{"database":"InterPro","id":"IPR027434","properties":[{"key":"EntryName","value":"Homing_endonucl"}]},{"database":"InterPro","id":"IPR004860","properties":[{"key":"EntryName","value":"LAGLIDADG_dom"}]},{"database":"PANTHER","id":"PTHR47539","properties":[{"key":"EntryName","value":"PENTATRICOPEPTIDE REPEAT-CONTAINING PROTEIN OTP51, CHLOROPLASTIC"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR47539:SF1","properties":[{"key":"EntryName","value":"PENTATRICOPEPTIDE REPEAT-CONTAINING PROTEIN OTP51, CHLOROPLASTIC"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF03161","properties":[{"key":"EntryName","value":"LAGLIDADG_2"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF55608","properties":[{"key":"EntryName","value":"Homing endonucleases"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MNKINKSDIIGKSPNSKLMREYKASLFSLNKNQYEASIDLMLGDASLQTQNKGKSYRMKFEWGNKQLAYSTHVFNLFDEWVLSVPHKKERYSPKGNLVINWGFQTISHNAFNFLAELFINNNKKSVKINLIKNHLTARGLAYWFMDDGGKLDYNLNSKNTSVVLNTQSFSDSEVSQMIKELNDKFRLNCNIRENKGTKVIVINS","length":204,"molWeight":23515,"crc64":"57208920A455F5E2","md5":"A57783D1347A51A8718A310D04DE0205"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"SIMILARITY":1},"countByFeatureType":{"Domain":1},"uniParcId":"UPI0011239F9B"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0A4Y5SHU7","uniProtkbId":"A0A4Y5SHU7_9AGAM","entryAudit":{"firstPublicDate":"2019-09-18","lastAnnotationUpdateDate":"2026-01-28","lastSequenceUpdateDate":"2019-09-18","entryVersion":10,"sequenceVersion":1},"annotationScore":1.0,"organism":{"scientificName":"Rhizopogon vinicolor","taxonId":80600,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"QDA23251.1"}],"lineage":["Eukaryota","Fungi","Dikarya","Basidiomycota","Agaricomycotina","Agaricomycetes","Agaricomycetidae","Boletales","Suillineae","Rhizopogonaceae","Rhizopogon"]},"proteinExistence":"4: Predicted","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"QDA23251.1"}],"value":"Uncharacterized protein"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"QDA23251.1"}],"value":"orf149"}}],"features":[{"type":"Coiled coil","location":{"start":{"value":74,"modifier":"EXACT"},"end":{"value":129,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Coils"}]}],"geneLocations":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"QDA23251.1"}],"geneEncodingType":"Mitochondrion"}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Coils"}],"id":"KW-0175","category":"Domain","name":"Coiled coil"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"QDA23251.1"}],"id":"KW-0496","category":"Cellular component","name":"Mitochondrion"}],"references":[{"referenceNumber":1,"citation":{"id":"31635252","citationType":"journal article","authors":["Li Q.","Ren Y.","Shi X.","Peng L.","Zhao J.","Song Y.","Zhao G."],"citationCrossReferences":[{"database":"PubMed","id":"31635252"}],"title":"Comparative Mitochondrial Genome Analysis of Two Ectomycorrhizal Fungi (Rhizopogon) Reveals Dynamic Changes of Intron and Phylogenetic Relationships of the Subphylum Agaricomycotina.","publicationDate":"0","journal":"Int. J. Mol. Sci.","firstPage":"0","lastPage":"0","volume":"20"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"QDA23251.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"MH794153","properties":[{"key":"ProteinId","value":"QDA23251.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"RefSeq","id":"YP_009649336.1","properties":[{"key":"NucleotideSequenceId","value":"NC_042699.1"}]},{"database":"AlphaFoldDB","id":"A0A4Y5SHU7","properties":[{"key":"Description","value":"-"}]},{"database":"GeneID","id":"40487026","properties":[{"key":"Description","value":"-"}]}],"sequence":{"value":"MDKINLTNLFRSLSLVSLIATFYGLMQNKSINEILNELEKEKFNNNLINEKYKNLLENKLNETELNKIISNEKIKGLMEEMNLLKNKISNQNLLNESDIKNIDNTNNILNQLKDINQTFQNSNNKLNNIMNSIESYINSKNNNVISLWD","length":149,"molWeight":17381,"crc64":"F415FD4E3B827113","md5":"5D6D26AACD10ED25A3BEF45892E51B59"},"extraAttributes":{"countByFeatureType":{"Coiled coil":1},"uniParcId":"UPI00111E6827"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0A4Y5SHU8","uniProtkbId":"A0A4Y5SHU8_9AGAM","entryAudit":{"firstPublicDate":"2019-09-18","lastAnnotationUpdateDate":"2026-11-04","lastSequenceUpdateDate":"2019-09-18","entryVersion":9,"sequenceVersion":1},"annotationScore":1.0,"organism":{"scientificName":"Rhizopogon vinicolor","taxonId":80600,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"QDA23253.1"}],"lineage":["Eukaryota","Fungi","Dikarya","Basidiomycota","Agaricomycotina","Agaricomycetes","Agaricomycetidae","Boletales","Suillineae","Rhizopogonaceae","Rhizopogon"]},"proteinExistence":"4: Predicted","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"QDA23253.1"}],"value":"Uncharacterized protein"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"QDA23253.1"}],"value":"orf294"}}],"features":[{"type":"Transmembrane","location":{"start":{"value":53,"modifier":"EXACT"},"end":{"value":71,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":200,"modifier":"EXACT"},"end":{"value":227,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":270,"modifier":"EXACT"},"end":{"value":292,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]}],"geneLocations":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"QDA23253.1"}],"geneEncodingType":"Mitochondrion"}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"QDA23253.1"}],"id":"KW-0496","category":"Cellular component","name":"Mitochondrion"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-1133","category":"Domain","name":"Transmembrane helix"}],"references":[{"referenceNumber":1,"citation":{"id":"31635252","citationType":"journal article","authors":["Li Q.","Ren Y.","Shi X.","Peng L.","Zhao J.","Song Y.","Zhao G."],"citationCrossReferences":[{"database":"PubMed","id":"31635252"}],"title":"Comparative Mitochondrial Genome Analysis of Two Ectomycorrhizal Fungi (Rhizopogon) Reveals Dynamic Changes of Intron and Phylogenetic Relationships of the Subphylum Agaricomycotina.","publicationDate":"0","journal":"Int. J. Mol. Sci.","firstPage":"0","lastPage":"0","volume":"20"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"QDA23253.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"MH794153","properties":[{"key":"ProteinId","value":"QDA23253.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"RefSeq","id":"YP_009649338.1","properties":[{"key":"NucleotideSequenceId","value":"NC_042699.1"}]},{"database":"AlphaFoldDB","id":"A0A4Y5SHU8","properties":[{"key":"Description","value":"-"}]},{"database":"GeneID","id":"40487028","properties":[{"key":"Description","value":"-"}]}],"sequence":{"value":"MNIIIIISFLVDLFNKELSFLINSILKHPRIMYISLRDYFHLLTNILSFIFKYLFYLYLIYILYIFLNFYIHFDETFINNMIILSFDDFENLANNVNDPSLNNSSHTPINYNNLIDNLPKTIAGYGAYKVGMEVSKNVPSIGGKALIIASVGALAAGSITFGTLVGENLAEKFIKDNKNKLFFNMINSNNINLNLFPYNLLFSMSTINLSSISFLIIISNILIVEYINRQNINLLDYLPNFIKSSKLYNIINFILNKYINIWSITKTPFLIISIISLFIGLLINQLGLYLIINN","length":294,"molWeight":33786,"crc64":"38F2F763A772B37A","md5":"EA90B7334D145112DEFEC45B8493EE88"},"extraAttributes":{"countByFeatureType":{"Transmembrane":3},"uniParcId":"UPI00111DAB7B"}}]}