{"results":[{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0A126X2X9","uniProtkbId":"A0A126X2X9_GOOPU","entryAudit":{"firstPublicDate":"2016-05-11","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2016-05-11","entryVersion":36,"sequenceVersion":1},"annotationScore":3.0,"organism":{"scientificName":"Goodyera pubescens","commonName":"Downy rattlesnake plantain","synonyms":["Neottia pubescens"],"taxonId":78780,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AML79049.1"}],"lineage":["Eukaryota","Viridiplantae","Streptophyta","Embryophyta","Tracheophyta","Spermatophyta","Magnoliopsida","Liliopsida","Asparagales","Orchidaceae","Orchidoideae","Cranichideae","Goodyerinae","Goodyera"]},"proteinExistence":"2: Evidence at transcript level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU10027"}],"value":"Serine/threonine-protein"},"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU10027"}],"value":"2.7.11.1"}]}},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ANC96915.1"}],"value":"PHOT1"}}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00058424"}],"value":"Protein kinase that acts as a blue light photoreceptor in a signal-transduction pathway for phototropic responses. Regulates a wide range of physiological activities in plants that maximize the efficiency of photosynthesis, such as chloroplast relocations, stomata opening, and leaf expansion"}],"commentType":"FUNCTION"},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:17989"},{"database":"Rhea","id":"RHEA-COMP:9863"},{"database":"Rhea","id":"RHEA-COMP:11604"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:29999"},{"database":"ChEBI","id":"CHEBI:30616"},{"database":"ChEBI","id":"CHEBI:83421"},{"database":"ChEBI","id":"CHEBI:456216"}],"ecNumber":"2.7.11.1","evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00048679"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU10027"}]}},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:46608"},{"database":"Rhea","id":"RHEA-COMP:11060"},{"database":"Rhea","id":"RHEA-COMP:11605"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:30013"},{"database":"ChEBI","id":"CHEBI:30616"},{"database":"ChEBI","id":"CHEBI:61977"},{"database":"ChEBI","id":"CHEBI:456216"}],"ecNumber":"2.7.11.1","evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00047899"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU10027"}]}},{"commentType":"COFACTOR","cofactors":[{"name":"FMN","evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00001917"}],"cofactorCrossReference":{"database":"ChEBI","id":"CHEBI:58210"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00009903"}],"value":"Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family"}],"commentType":"SIMILARITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00159"}],"value":"Belongs to the protein kinase superfamily. Ser/Thr protein kinase family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Domain","location":{"start":{"value":177,"modifier":"EXACT"},"end":{"value":226,"modifier":"EXACT"}},"description":"PAS","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50112"}]},{"type":"Domain","location":{"start":{"value":251,"modifier":"EXACT"},"end":{"value":305,"modifier":"EXACT"}},"description":"PAC","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50113"}]},{"type":"Domain","location":{"start":{"value":461,"modifier":"EXACT"},"end":{"value":530,"modifier":"EXACT"}},"description":"PAS","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50112"}]},{"type":"Domain","location":{"start":{"value":531,"modifier":"EXACT"},"end":{"value":585,"modifier":"EXACT"}},"description":"PAC","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50113"}]},{"type":"Domain","location":{"start":{"value":658,"modifier":"EXACT"},"end":{"value":947,"modifier":"EXACT"}},"description":"Protein kinase","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50011"}]},{"type":"Region","location":{"start":{"value":35,"modifier":"EXACT"},"end":{"value":173,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":354,"modifier":"EXACT"},"end":{"value":409,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":421,"modifier":"EXACT"},"end":{"value":453,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":35,"modifier":"EXACT"},"end":{"value":63,"modifier":"EXACT"}},"description":"Polar residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":81,"modifier":"EXACT"},"end":{"value":101,"modifier":"EXACT"}},"description":"Pro residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":136,"modifier":"EXACT"},"end":{"value":160,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":361,"modifier":"EXACT"},"end":{"value":371,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":443,"modifier":"EXACT"},"end":{"value":453,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Active site","location":{"start":{"value":783,"modifier":"EXACT"},"end":{"value":783,"modifier":"EXACT"}},"description":"Proton acceptor","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU10027"}]},{"type":"Binding site","location":{"start":{"value":687,"modifier":"EXACT"},"end":{"value":687,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:30616"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU10141"}],"ligand":{"name":"ATP","id":"ChEBI:CHEBI:30616"}}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022840"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU10141"}],"id":"KW-0067","category":"Ligand","name":"ATP-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022991"}],"id":"KW-0157","category":"Ligand","name":"Chromophore"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022630"}],"id":"KW-0285","category":"Ligand","name":"Flavoprotein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022643"}],"id":"KW-0288","category":"Ligand","name":"FMN"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022777"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00159"}],"id":"KW-0418","category":"Molecular function","name":"Kinase"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022741"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU10141"}],"id":"KW-0547","category":"Ligand","name":"Nucleotide-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022543"}],"id":"KW-0600","category":"Molecular function","name":"Photoreceptor protein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023170"}],"id":"KW-0675","category":"Molecular function","name":"Receptor"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022737"}],"id":"KW-0677","category":"Domain","name":"Repeat"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022606"}],"id":"KW-0716","category":"Biological process","name":"Sensory transduction"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022527"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00159"}],"id":"KW-0723","category":"Molecular function","name":"Serine/threonine-protein kinase"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022679"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00159"}],"id":"KW-0808","category":"Molecular function","name":"Transferase"}],"references":[{"referenceNumber":1,"citation":{"id":"26322073","citationType":"journal article","authors":["Li F.W.","Rothfels C.J.","Melkonian M.","Villarreal J.C.","Stevenson D.W.","Graham S.W.","Wong G.K.","Mathews S.","Pryer K.M."],"citationCrossReferences":[{"database":"PubMed","id":"26322073"}],"title":"The origin and evolution of phototropins.","publicationDate":"2015","journal":"Front. Plant Sci.","firstPage":"637","lastPage":"637","volume":"6"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ANC96915.1"}]},{"referenceNumber":2,"citation":{"id":"CI-F1K69Q5IC8RGR","citationType":"submission","authors":["Noorani M."],"publicationDate":"JUL-2015","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ANC96915.1"}]},{"referenceNumber":3,"citation":{"id":"26929367","citationType":"journal article","authors":["Glantz S.T.","Carpenter E.J.","Melkonian M.","Gardner K.H.","Boyden E.S.","Wong G.K.","Chow B.Y."],"citationCrossReferences":[{"database":"PubMed","id":"26929367"},{"database":"DOI","id":"10.1073/pnas.1509428113"}],"title":"Functional and topological diversity of LOV domain photoreceptors.","publicationDate":"2016","journal":"Proc. Natl. Acad. Sci. U.S.A.","firstPage":"E1442","lastPage":"E1451","volume":"113"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AML79049.1"}],"value":"VTUS_2000548","type":"STRAIN"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AML79049.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"KU701444","properties":[{"key":"ProteinId","value":"AML79049.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"KT321790","properties":[{"key":"ProteinId","value":"ANC96915.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"AlphaFoldDB","id":"A0A126X2X9","properties":[{"key":"Description","value":"-"}]},{"database":"GO","id":"GO:0005524","properties":[{"key":"GoTerm","value":"F:ATP binding"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniRule"}]},{"database":"GO","id":"GO:0009882","properties":[{"key":"GoTerm","value":"F:blue light photoreceptor activity"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0004674","properties":[{"key":"GoTerm","value":"F:protein serine/threonine kinase activity"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-EC"}]},{"database":"CDD","id":"cd00130","properties":[{"key":"EntryName","value":"PAS"},{"key":"MatchStatus","value":"2"}]},{"database":"CDD","id":"cd05574","properties":[{"key":"EntryName","value":"STKc_phototropin_like"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.30.200.20:FF:000133","properties":[{"key":"EntryName","value":"LOV domain-containing protein"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.30.450.20:FF:000002","properties":[{"key":"EntryName","value":"LOV domain-containing protein"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.10.510.10:FF:000265","properties":[{"key":"EntryName","value":"Putative LOV domain-containing protein"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.30.450.20:FF:000036","properties":[{"key":"EntryName","value":"Putative LOV domain-containing protein"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.30.450.20","properties":[{"key":"EntryName","value":"PAS domain"},{"key":"MatchStatus","value":"2"}]},{"database":"Gene3D","id":"3.30.200.20","properties":[{"key":"EntryName","value":"Phosphorylase Kinase, domain 1"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.10.510.10","properties":[{"key":"EntryName","value":"Transferase(Phosphotransferase) domain 1"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR011009","properties":[{"key":"EntryName","value":"Kinase-like_dom_sf"}]},{"database":"InterPro","id":"IPR001610","properties":[{"key":"EntryName","value":"PAC"}]},{"database":"InterPro","id":"IPR000014","properties":[{"key":"EntryName","value":"PAS"}]},{"database":"InterPro","id":"IPR000700","properties":[{"key":"EntryName","value":"PAS-assoc_C"}]},{"database":"InterPro","id":"IPR035965","properties":[{"key":"EntryName","value":"PAS-like_dom_sf"}]},{"database":"InterPro","id":"IPR000719","properties":[{"key":"EntryName","value":"Prot_kinase_dom"}]},{"database":"InterPro","id":"IPR017441","properties":[{"key":"EntryName","value":"Protein_kinase_ATP_BS"}]},{"database":"InterPro","id":"IPR008271","properties":[{"key":"EntryName","value":"Ser/Thr_kinase_AS"}]},{"database":"NCBIfam","id":"TIGR00229","properties":[{"key":"EntryName","value":"sensory_box"},{"key":"MatchStatus","value":"2"}]},{"database":"PANTHER","id":"PTHR45637","properties":[{"key":"EntryName","value":"FLIPPASE KINASE 1-RELATED"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF13426","properties":[{"key":"EntryName","value":"PAS_9"},{"key":"MatchStatus","value":"2"}]},{"database":"Pfam","id":"PF00069","properties":[{"key":"EntryName","value":"Pkinase"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00086","properties":[{"key":"EntryName","value":"PAC"},{"key":"MatchStatus","value":"2"}]},{"database":"SMART","id":"SM00091","properties":[{"key":"EntryName","value":"PAS"},{"key":"MatchStatus","value":"2"}]},{"database":"SMART","id":"SM00220","properties":[{"key":"EntryName","value":"S_TKc"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF101447","properties":[{"key":"EntryName","value":"Formin homology 2 domain (FH2 domain)"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF56112","properties":[{"key":"EntryName","value":"Protein kinase-like (PK-like)"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF55785","properties":[{"key":"EntryName","value":"PYP-like sensor domain (PAS domain)"},{"key":"MatchStatus","value":"2"}]},{"database":"PROSITE","id":"PS50113","properties":[{"key":"EntryName","value":"PAC"},{"key":"MatchStatus","value":"2"}]},{"database":"PROSITE","id":"PS50112","properties":[{"key":"EntryName","value":"PAS"},{"key":"MatchStatus","value":"2"}]},{"database":"PROSITE","id":"PS00107","properties":[{"key":"EntryName","value":"PROTEIN_KINASE_ATP"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50011","properties":[{"key":"EntryName","value":"PROTEIN_KINASE_DOM"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00108","properties":[{"key":"EntryName","value":"PROTEIN_KINASE_ST"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MEEKEDLPFHYAYKPSSLLPSLPYDSRGSLEVFNPSSFPSAVTGTAESSSSRPHFTPPFATSHQPHRLSPPQEEISRPWMAIPPPSAAAPPPPPPPPPPPSGSLSDVGTAEKRAAEWGLVLKTDGETGKPQGIGVRKSDDDPSRGRGGRRDSGGSRRSSEDSEVFDGGRQRGGIPRVSEELKEALSAFQQTFVVSDATKPDHPIMYASAGFFRMTGYSSQEVIGRNCRFLQGSGTDPAEISKIREVLASGSNYCGRILNYKKDGTPFWNLLTVAPIKDDEGNVLKFIGMQVEVSKYTEGSKETMCRPNGLPESLIKYDARQKDKARSSLSELVIAVKDPNALQDSTNSFLFGKSEGGADIMKPDAHGRRSSENTTPFRRNSRGSMRSSMQKIDEFPEGRKKPRKSGFSSLMGIIGIRPNHEEEKDLEVSLEANPPIEDDDERPESFDDQERRKEMRKGIDLATTLERIEKNFVITDPRLPDNPIIFASDSFLELTEYSREEILGRNCRFLQGPETDPTTVRKIRDAIDNQRDVTVQLINYKKSGKKFWNLFHLQPMRDQKGEVQYFIGVQLDGSSHVDPVHNCIPETTAKEGAKVVKETAENVDEAVRELPDANSNLEDLWAKHSKIVLPKPHKRNSSSWMAIQKILESGEKISLKHFRPVKPLGSGDTGSVHLVELVETGEHFAMKTMDKNVMLNRNKVHRVCAEREILDTLDHPFLPTLYASFQTKSHVCLVTDYCPGGELFVLLDRQPLKVLKEDAVRFYAAEVVIALEYLHCQGIIYRDLKPENILLQRDGHISLTDFDLSCLTSCKPQLLHPNIRDRRKKQRKKGRTPPVFVAEPMRASNSFVGTEEYIAPEIITGAGHTSAVDWWALGVLLYEMLYGYTPFRAKTRQKTFANILQKDLKFPRNISVSLSAKQLIFRLLHRDPKNRFGSCEGANEIKKHPFFSGINWALIRCLSPPKLEAPVFDPEMEKDSKLVDAEYQNIHISVF","length":991,"molWeight":111192,"crc64":"C6AD14F45670DE38","md5":"F75CD22C1D3FD11E9ED6733370C56F99"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"CATALYTIC ACTIVITY":2,"COFACTOR":1,"SIMILARITY":2},"countByFeatureType":{"Domain":5,"Region":3,"Compositional bias":5,"Active site":1,"Binding site":1},"uniParcId":"UPI00078B8E5D"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0A126X2Y3","uniProtkbId":"A0A126X2Y3_GOOPU","entryAudit":{"firstPublicDate":"2016-05-11","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2016-05-11","entryVersion":35,"sequenceVersion":1},"annotationScore":3.0,"organism":{"scientificName":"Goodyera pubescens","commonName":"Downy rattlesnake plantain","synonyms":["Neottia pubescens"],"taxonId":78780,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AML79052.1"}],"lineage":["Eukaryota","Viridiplantae","Streptophyta","Embryophyta","Tracheophyta","Spermatophyta","Magnoliopsida","Liliopsida","Asparagales","Orchidaceae","Orchidoideae","Cranichideae","Goodyerinae","Goodyera"]},"proteinExistence":"2: Evidence at transcript level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU10027"}],"value":"Serine/threonine-protein"},"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU10027"}],"value":"2.7.11.1"}]}},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ANC96920.1"}],"value":"PHOT2"}}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00058424"}],"value":"Protein kinase that acts as a blue light photoreceptor in a signal-transduction pathway for phototropic responses. Regulates a wide range of physiological activities in plants that maximize the efficiency of photosynthesis, such as chloroplast relocations, stomata opening, and leaf expansion"}],"commentType":"FUNCTION"},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:17989"},{"database":"Rhea","id":"RHEA-COMP:9863"},{"database":"Rhea","id":"RHEA-COMP:11604"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:29999"},{"database":"ChEBI","id":"CHEBI:30616"},{"database":"ChEBI","id":"CHEBI:83421"},{"database":"ChEBI","id":"CHEBI:456216"}],"ecNumber":"2.7.11.1","evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00048679"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU10027"}]}},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:46608"},{"database":"Rhea","id":"RHEA-COMP:11060"},{"database":"Rhea","id":"RHEA-COMP:11605"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:30013"},{"database":"ChEBI","id":"CHEBI:30616"},{"database":"ChEBI","id":"CHEBI:61977"},{"database":"ChEBI","id":"CHEBI:456216"}],"ecNumber":"2.7.11.1","evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00047899"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU10027"}]}},{"commentType":"COFACTOR","cofactors":[{"name":"FMN","evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00001917"}],"cofactorCrossReference":{"database":"ChEBI","id":"CHEBI:58210"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00009903"}],"value":"Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family"}],"commentType":"SIMILARITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00159"}],"value":"Belongs to the protein kinase superfamily. Ser/Thr protein kinase family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Domain","location":{"start":{"value":118,"modifier":"EXACT"},"end":{"value":191,"modifier":"EXACT"}},"description":"PAS","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50112"}]},{"type":"Domain","location":{"start":{"value":192,"modifier":"EXACT"},"end":{"value":246,"modifier":"EXACT"}},"description":"PAC","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50113"}]},{"type":"Domain","location":{"start":{"value":388,"modifier":"EXACT"},"end":{"value":461,"modifier":"EXACT"}},"description":"PAS","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50112"}]},{"type":"Domain","location":{"start":{"value":462,"modifier":"EXACT"},"end":{"value":516,"modifier":"EXACT"}},"description":"PAC","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50113"}]},{"type":"Domain","location":{"start":{"value":589,"modifier":"EXACT"},"end":{"value":874,"modifier":"EXACT"}},"description":"Protein kinase","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50011"}]},{"type":"Region","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":56,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":322,"modifier":"EXACT"},"end":{"value":349,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":23,"modifier":"EXACT"},"end":{"value":32,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":38,"modifier":"EXACT"},"end":{"value":53,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Active site","location":{"start":{"value":714,"modifier":"EXACT"},"end":{"value":714,"modifier":"EXACT"}},"description":"Proton acceptor","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU10027"}]},{"type":"Binding site","location":{"start":{"value":618,"modifier":"EXACT"},"end":{"value":618,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:30616"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU10141"}],"ligand":{"name":"ATP","id":"ChEBI:CHEBI:30616"}}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022840"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU10141"}],"id":"KW-0067","category":"Ligand","name":"ATP-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022991"}],"id":"KW-0157","category":"Ligand","name":"Chromophore"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022630"}],"id":"KW-0285","category":"Ligand","name":"Flavoprotein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022643"}],"id":"KW-0288","category":"Ligand","name":"FMN"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022777"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00159"}],"id":"KW-0418","category":"Molecular function","name":"Kinase"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022741"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU10141"}],"id":"KW-0547","category":"Ligand","name":"Nucleotide-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022543"}],"id":"KW-0600","category":"Molecular function","name":"Photoreceptor protein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023170"}],"id":"KW-0675","category":"Molecular function","name":"Receptor"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022737"}],"id":"KW-0677","category":"Domain","name":"Repeat"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022606"}],"id":"KW-0716","category":"Biological process","name":"Sensory transduction"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022527"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00159"}],"id":"KW-0723","category":"Molecular function","name":"Serine/threonine-protein kinase"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022679"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00159"}],"id":"KW-0808","category":"Molecular function","name":"Transferase"}],"references":[{"referenceNumber":1,"citation":{"id":"26322073","citationType":"journal article","authors":["Li F.W.","Rothfels C.J.","Melkonian M.","Villarreal J.C.","Stevenson D.W.","Graham S.W.","Wong G.K.","Mathews S.","Pryer K.M."],"citationCrossReferences":[{"database":"PubMed","id":"26322073"}],"title":"The origin and evolution of phototropins.","publicationDate":"2015","journal":"Front. Plant Sci.","firstPage":"637","lastPage":"637","volume":"6"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ANC96920.1"}]},{"referenceNumber":2,"citation":{"id":"CI-F1K69Q5IC8RGR","citationType":"submission","authors":["Noorani M."],"publicationDate":"JUL-2015","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ANC96920.1"}]},{"referenceNumber":3,"citation":{"id":"26929367","citationType":"journal article","authors":["Glantz S.T.","Carpenter E.J.","Melkonian M.","Gardner K.H.","Boyden E.S.","Wong G.K.","Chow B.Y."],"citationCrossReferences":[{"database":"PubMed","id":"26929367"},{"database":"DOI","id":"10.1073/pnas.1509428113"}],"title":"Functional and topological diversity of LOV domain photoreceptors.","publicationDate":"2016","journal":"Proc. Natl. Acad. Sci. U.S.A.","firstPage":"E1442","lastPage":"E1451","volume":"113"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AML79052.1"}],"value":"VTUS_2052223","type":"STRAIN"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AML79052.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"KU701448","properties":[{"key":"ProteinId","value":"AML79052.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"KT321795","properties":[{"key":"ProteinId","value":"ANC96920.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"AlphaFoldDB","id":"A0A126X2Y3","properties":[{"key":"Description","value":"-"}]},{"database":"GO","id":"GO:0005524","properties":[{"key":"GoTerm","value":"F:ATP binding"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniRule"}]},{"database":"GO","id":"GO:0009882","properties":[{"key":"GoTerm","value":"F:blue light photoreceptor activity"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0004674","properties":[{"key":"GoTerm","value":"F:protein serine/threonine kinase activity"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-EC"}]},{"database":"CDD","id":"cd00130","properties":[{"key":"EntryName","value":"PAS"},{"key":"MatchStatus","value":"2"}]},{"database":"CDD","id":"cd05574","properties":[{"key":"EntryName","value":"STKc_phototropin_like"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.30.200.20:FF:000133","properties":[{"key":"EntryName","value":"LOV domain-containing protein"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.30.450.20:FF:000002","properties":[{"key":"EntryName","value":"LOV domain-containing protein"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.10.510.10:FF:000265","properties":[{"key":"EntryName","value":"Putative LOV domain-containing protein"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.30.450.20:FF:000036","properties":[{"key":"EntryName","value":"Putative LOV domain-containing protein"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.30.450.20","properties":[{"key":"EntryName","value":"PAS domain"},{"key":"MatchStatus","value":"2"}]},{"database":"Gene3D","id":"3.30.200.20","properties":[{"key":"EntryName","value":"Phosphorylase Kinase, domain 1"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.10.510.10","properties":[{"key":"EntryName","value":"Transferase(Phosphotransferase) domain 1"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR011009","properties":[{"key":"EntryName","value":"Kinase-like_dom_sf"}]},{"database":"InterPro","id":"IPR001610","properties":[{"key":"EntryName","value":"PAC"}]},{"database":"InterPro","id":"IPR000014","properties":[{"key":"EntryName","value":"PAS"}]},{"database":"InterPro","id":"IPR000700","properties":[{"key":"EntryName","value":"PAS-assoc_C"}]},{"database":"InterPro","id":"IPR035965","properties":[{"key":"EntryName","value":"PAS-like_dom_sf"}]},{"database":"InterPro","id":"IPR000719","properties":[{"key":"EntryName","value":"Prot_kinase_dom"}]},{"database":"InterPro","id":"IPR017441","properties":[{"key":"EntryName","value":"Protein_kinase_ATP_BS"}]},{"database":"InterPro","id":"IPR008271","properties":[{"key":"EntryName","value":"Ser/Thr_kinase_AS"}]},{"database":"NCBIfam","id":"TIGR00229","properties":[{"key":"EntryName","value":"sensory_box"},{"key":"MatchStatus","value":"2"}]},{"database":"PANTHER","id":"PTHR45637","properties":[{"key":"EntryName","value":"FLIPPASE KINASE 1-RELATED"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF13426","properties":[{"key":"EntryName","value":"PAS_9"},{"key":"MatchStatus","value":"2"}]},{"database":"Pfam","id":"PF00069","properties":[{"key":"EntryName","value":"Pkinase"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00086","properties":[{"key":"EntryName","value":"PAC"},{"key":"MatchStatus","value":"2"}]},{"database":"SMART","id":"SM00091","properties":[{"key":"EntryName","value":"PAS"},{"key":"MatchStatus","value":"2"}]},{"database":"SMART","id":"SM00220","properties":[{"key":"EntryName","value":"S_TKc"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF56112","properties":[{"key":"EntryName","value":"Protein kinase-like (PK-like)"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF55785","properties":[{"key":"EntryName","value":"PYP-like sensor domain (PAS domain)"},{"key":"MatchStatus","value":"2"}]},{"database":"PROSITE","id":"PS50113","properties":[{"key":"EntryName","value":"PAC"},{"key":"MatchStatus","value":"2"}]},{"database":"PROSITE","id":"PS50112","properties":[{"key":"EntryName","value":"PAS"},{"key":"MatchStatus","value":"2"}]},{"database":"PROSITE","id":"PS00107","properties":[{"key":"EntryName","value":"PROTEIN_KINASE_ATP"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50011","properties":[{"key":"EntryName","value":"PROTEIN_KINASE_DOM"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00108","properties":[{"key":"EntryName","value":"PROTEIN_KINASE_ST"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MTENTKIAKLPAVMGEGPSNPPPEEKLPKNCKEFPVQDSDKDLNQNEIEESKETGSNLSIDQRVAEWGLSVRLRDSKGQIDFVPSYLEGGKQSIENVPETTRRSKESYNATSSRLPRISQELKEALSSLQQTFVVSDARRPECPIMYASVGFYSMTGYSVKEVIGRNCRFLQGPGTDEMEVAKIREALRTGKSYCGRILNYMKNGTPFWNLLTITPIRDERGNVIKFIGMQVEVSKYTEGLNDKTLRPNALPVSLIRYDDRQKERAMSSITEVVQRVKHPRSHSKSIELDSISNVEECEKLYTNSPLPVIANIKNLKSPRMTPLHDFRNESLGTSNRKSGRSSLMGFRRKQSLAEKPEIKIEPEILMTRDVQRTESWDRMEREKDIRQAIDLATTLERIEKNFVITDPRLPDNPIIFASDSFLDLTEYSREEILGRNCRFLQGPETDKATVSKIRDAIREQRETTVQLINYTKNGKKFWNIFHLQPMRDQKGELQYFIGVQLDGSDYVEPLHNRLSERTEMNSSKLVKATAENVNEAVRELPDANLRPEDLWAIHSKPVFPKPHKGNKSSWIAIEQITGKSEQITLKHFRPIKPLGCGDTGSVHLVELVGTNELFAMKAMDKAVMMNRNKVHRVCIERQIYSLLDHPFLPTLYTSFQTTTHVCLITDFCPGGELFALLDKQPMKIIKEAAARFYAAEVVVGLEYLHCLGIIYRDLKPENILLQEDGHIMLTDFDLSFLTSCKPQVIKQTVMTRKSKARLPPLFVAEPSTQSNSFVGTEEYIAPEIITGATHSSAIDWWALGILLYEMLYGRTPFRGKNRQKTFANILYKDLTFPSSIPVSLAARQLINGLLNRDPARRLGSNTGANEIKQHPFFCEINWPLIRCMSAPELVIPLEQITKEINSKPKDAKSDDEDMLIKSMEIL","length":923,"molWeight":105052,"crc64":"74262D3690475AA0","md5":"D144511294F482C1F597B5EB4F7A6464"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"CATALYTIC ACTIVITY":2,"COFACTOR":1,"SIMILARITY":2},"countByFeatureType":{"Domain":5,"Region":2,"Compositional bias":2,"Active site":1,"Binding site":1},"uniParcId":"UPI00078D2425"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0A126X3Q7","uniProtkbId":"A0A126X3Q7_GOOPU","entryAudit":{"firstPublicDate":"2016-05-11","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2016-05-11","entryVersion":36,"sequenceVersion":1},"annotationScore":3.0,"organism":{"scientificName":"Goodyera pubescens","commonName":"Downy rattlesnake plantain","synonyms":["Neottia pubescens"],"taxonId":78780,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AML79050.1"}],"lineage":["Eukaryota","Viridiplantae","Streptophyta","Embryophyta","Tracheophyta","Spermatophyta","Magnoliopsida","Liliopsida","Asparagales","Orchidaceae","Orchidoideae","Cranichideae","Goodyerinae","Goodyera"]},"proteinExistence":"2: Evidence at transcript level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU10027"}],"value":"Serine/threonine-protein"},"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU10027"}],"value":"2.7.11.1"}]}},"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00058424"}],"value":"Protein kinase that acts as a blue light photoreceptor in a signal-transduction pathway for phototropic responses. Regulates a wide range of physiological activities in plants that maximize the efficiency of photosynthesis, such as chloroplast relocations, stomata opening, and leaf expansion"}],"commentType":"FUNCTION"},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:17989"},{"database":"Rhea","id":"RHEA-COMP:9863"},{"database":"Rhea","id":"RHEA-COMP:11604"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:29999"},{"database":"ChEBI","id":"CHEBI:30616"},{"database":"ChEBI","id":"CHEBI:83421"},{"database":"ChEBI","id":"CHEBI:456216"}],"ecNumber":"2.7.11.1","evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00048679"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU10027"}]}},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:46608"},{"database":"Rhea","id":"RHEA-COMP:11060"},{"database":"Rhea","id":"RHEA-COMP:11605"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:30013"},{"database":"ChEBI","id":"CHEBI:30616"},{"database":"ChEBI","id":"CHEBI:61977"},{"database":"ChEBI","id":"CHEBI:456216"}],"ecNumber":"2.7.11.1","evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00047899"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU10027"}]}},{"commentType":"COFACTOR","cofactors":[{"name":"FMN","evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00001917"}],"cofactorCrossReference":{"database":"ChEBI","id":"CHEBI:58210"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00009903"}],"value":"Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family"}],"commentType":"SIMILARITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00159"}],"value":"Belongs to the protein kinase superfamily. Ser/Thr protein kinase family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Domain","location":{"start":{"value":32,"modifier":"EXACT"},"end":{"value":101,"modifier":"EXACT"}},"description":"PAS","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50112"}]},{"type":"Domain","location":{"start":{"value":102,"modifier":"EXACT"},"end":{"value":156,"modifier":"EXACT"}},"description":"PAC","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50113"}]},{"type":"Domain","location":{"start":{"value":229,"modifier":"EXACT"},"end":{"value":518,"modifier":"EXACT"}},"description":"Protein kinase","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50011"}]},{"type":"Region","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":24,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":14,"modifier":"EXACT"},"end":{"value":24,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Active site","location":{"start":{"value":354,"modifier":"EXACT"},"end":{"value":354,"modifier":"EXACT"}},"description":"Proton acceptor","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU10027"}]},{"type":"Binding site","location":{"start":{"value":258,"modifier":"EXACT"},"end":{"value":258,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:30616"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU10141"}],"ligand":{"name":"ATP","id":"ChEBI:CHEBI:30616"}}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022840"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU10141"}],"id":"KW-0067","category":"Ligand","name":"ATP-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022991"}],"id":"KW-0157","category":"Ligand","name":"Chromophore"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022630"}],"id":"KW-0285","category":"Ligand","name":"Flavoprotein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022643"}],"id":"KW-0288","category":"Ligand","name":"FMN"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022777"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00159"}],"id":"KW-0418","category":"Molecular function","name":"Kinase"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022741"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU10141"}],"id":"KW-0547","category":"Ligand","name":"Nucleotide-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022543"}],"id":"KW-0600","category":"Molecular function","name":"Photoreceptor protein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023170"}],"id":"KW-0675","category":"Molecular function","name":"Receptor"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022737"}],"id":"KW-0677","category":"Domain","name":"Repeat"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022606"}],"id":"KW-0716","category":"Biological process","name":"Sensory transduction"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022527"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00159"}],"id":"KW-0723","category":"Molecular function","name":"Serine/threonine-protein kinase"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022679"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00159"}],"id":"KW-0808","category":"Molecular function","name":"Transferase"}],"references":[{"referenceNumber":1,"citation":{"id":"26929367","citationType":"journal article","authors":["Glantz S.T.","Carpenter E.J.","Melkonian M.","Gardner K.H.","Boyden E.S.","Wong G.K.","Chow B.Y."],"citationCrossReferences":[{"database":"PubMed","id":"26929367"},{"database":"DOI","id":"10.1073/pnas.1509428113"}],"title":"Functional and topological diversity of LOV domain photoreceptors.","publicationDate":"2016","journal":"Proc. Natl. Acad. Sci. U.S.A.","firstPage":"E1442","lastPage":"E1451","volume":"113"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AML79050.1"}],"value":"VTUS_2000549","type":"STRAIN"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AML79050.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"KU701445","properties":[{"key":"ProteinId","value":"AML79050.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"AlphaFoldDB","id":"A0A126X3Q7","properties":[{"key":"Description","value":"-"}]},{"database":"GO","id":"GO:0005524","properties":[{"key":"GoTerm","value":"F:ATP binding"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniRule"}]},{"database":"GO","id":"GO:0009882","properties":[{"key":"GoTerm","value":"F:blue light photoreceptor activity"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0004674","properties":[{"key":"GoTerm","value":"F:protein serine/threonine kinase activity"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-EC"}]},{"database":"CDD","id":"cd00130","properties":[{"key":"EntryName","value":"PAS"},{"key":"MatchStatus","value":"1"}]},{"database":"CDD","id":"cd05574","properties":[{"key":"EntryName","value":"STKc_phototropin_like"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.30.200.20:FF:000133","properties":[{"key":"EntryName","value":"LOV domain-containing protein"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.30.450.20:FF:000002","properties":[{"key":"EntryName","value":"LOV domain-containing protein"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.10.510.10:FF:000265","properties":[{"key":"EntryName","value":"Putative LOV domain-containing protein"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.30.450.20","properties":[{"key":"EntryName","value":"PAS domain"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.30.200.20","properties":[{"key":"EntryName","value":"Phosphorylase Kinase, domain 1"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.10.510.10","properties":[{"key":"EntryName","value":"Transferase(Phosphotransferase) domain 1"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR011009","properties":[{"key":"EntryName","value":"Kinase-like_dom_sf"}]},{"database":"InterPro","id":"IPR001610","properties":[{"key":"EntryName","value":"PAC"}]},{"database":"InterPro","id":"IPR000014","properties":[{"key":"EntryName","value":"PAS"}]},{"database":"InterPro","id":"IPR000700","properties":[{"key":"EntryName","value":"PAS-assoc_C"}]},{"database":"InterPro","id":"IPR035965","properties":[{"key":"EntryName","value":"PAS-like_dom_sf"}]},{"database":"InterPro","id":"IPR000719","properties":[{"key":"EntryName","value":"Prot_kinase_dom"}]},{"database":"InterPro","id":"IPR017441","properties":[{"key":"EntryName","value":"Protein_kinase_ATP_BS"}]},{"database":"InterPro","id":"IPR008271","properties":[{"key":"EntryName","value":"Ser/Thr_kinase_AS"}]},{"database":"NCBIfam","id":"TIGR00229","properties":[{"key":"EntryName","value":"sensory_box"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR45637","properties":[{"key":"EntryName","value":"FLIPPASE KINASE 1-RELATED"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF13426","properties":[{"key":"EntryName","value":"PAS_9"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00069","properties":[{"key":"EntryName","value":"Pkinase"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00086","properties":[{"key":"EntryName","value":"PAC"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00220","properties":[{"key":"EntryName","value":"S_TKc"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF56112","properties":[{"key":"EntryName","value":"Protein kinase-like (PK-like)"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF55785","properties":[{"key":"EntryName","value":"PYP-like sensor domain (PAS domain)"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50113","properties":[{"key":"EntryName","value":"PAC"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50112","properties":[{"key":"EntryName","value":"PAS"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00107","properties":[{"key":"EntryName","value":"PROTEIN_KINASE_ATP"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50011","properties":[{"key":"EntryName","value":"PROTEIN_KINASE_DOM"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00108","properties":[{"key":"EntryName","value":"PROTEIN_KINASE_ST"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MEANPPIEEDDERPESFDDQERRKEMRKGIDLATTLERIEKNFVITDPRLPDNPIIFASDSFLELTEYSREEILGRNCRFLQGPETDPTTVRKIRDAIDNQRDVTVQLINYKKSGKKFWNLFHLQPMRDQKGEVQYFIGVQLDGSSHVDPVHNCIPETTAKEGAKVVKETAENVDEAVRELPDANSNLEDLWAKHSKIVLPKPHKRNSSSWMAIQKILESGEKISLKHFRPVKPLGSGDTGSVHLVELVETGEHFAMKTMDKNVMLNRNKVHRVCAEREILDTLDHPFLPTLYASFQTKSHVCLVTDYCPGGELFVLLDRQPLKVLKEDAVRFYAAEVVIALEYLHCQGIIYRDLKPENILLQRDGHISLTDFDLSCLTSCKPQLLHPNIRDRRKKQRKKGRTPPVFVAEPMRASNSFVGTEEYIAPEIITGAGHTSAVDWWALGVLLYEMLYGYTPFRAKTRQKTFANILQKDLKFPRNISVSLSAKQLIFRLLHRDPKNRFGSCEGANEIKKHPFFSGINWALIRCLSPPKLEAPVFDPEMEKDSKLVDAEYQNIHISVF","length":562,"molWeight":64398,"crc64":"107E097FBD80A566","md5":"CFC5D9AB5B106A6073DD6B776D934981"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"CATALYTIC ACTIVITY":2,"COFACTOR":1,"SIMILARITY":2},"countByFeatureType":{"Domain":3,"Region":1,"Compositional bias":1,"Active site":1,"Binding site":1},"uniParcId":"UPI00078CDD72"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0A126X2Z0","uniProtkbId":"A0A126X2Z0_GOOPU","entryAudit":{"firstPublicDate":"2016-05-11","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2016-05-11","entryVersion":30,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Goodyera pubescens","commonName":"Downy rattlesnake plantain","synonyms":["Neottia pubescens"],"taxonId":78780,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AML79051.1"}],"lineage":["Eukaryota","Viridiplantae","Streptophyta","Embryophyta","Tracheophyta","Spermatophyta","Magnoliopsida","Liliopsida","Asparagales","Orchidaceae","Orchidoideae","Cranichideae","Goodyerinae","Goodyera"]},"proteinExistence":"2: Evidence at transcript level","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AML79051.1"}],"value":"Putative LOV domain-containing protein"}}]},"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004906"}],"value":"Protein modification; protein ubiquitination"}],"commentType":"PATHWAY"},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004123"}],"value":"Nucleus","id":"SL-0191"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00007833"}],"value":"Belongs to the ADAGIO family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Domain","location":{"start":{"value":73,"modifier":"EXACT"},"end":{"value":104,"modifier":"EXACT"}},"description":"PAS","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50112"}]},{"type":"Region","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":38,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":10,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023108"}],"id":"KW-0090","category":"Biological process","name":"Biological rhythms"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022991"}],"id":"KW-0157","category":"Ligand","name":"Chromophore"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022630"}],"id":"KW-0285","category":"Ligand","name":"Flavoprotein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022643"}],"id":"KW-0288","category":"Ligand","name":"FMN"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022441"}],"id":"KW-0880","category":"Domain","name":"Kelch repeat"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023242"}],"id":"KW-0539","category":"Cellular component","name":"Nucleus"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022543"}],"id":"KW-0600","category":"Molecular function","name":"Photoreceptor protein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023170"}],"id":"KW-0675","category":"Molecular function","name":"Receptor"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022737"}],"id":"KW-0677","category":"Domain","name":"Repeat"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022606"}],"id":"KW-0716","category":"Biological process","name":"Sensory transduction"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022786"}],"id":"KW-0833","category":"Biological process","name":"Ubl conjugation pathway"}],"references":[{"referenceNumber":1,"citation":{"id":"26929367","citationType":"journal article","authors":["Glantz S.T.","Carpenter E.J.","Melkonian M.","Gardner K.H.","Boyden E.S.","Wong G.K.","Chow B.Y."],"citationCrossReferences":[{"database":"PubMed","id":"26929367"},{"database":"DOI","id":"10.1073/pnas.1509428113"}],"title":"Functional and topological diversity of LOV domain photoreceptors.","publicationDate":"2016","journal":"Proc. Natl. Acad. Sci. U.S.A.","firstPage":"E1442","lastPage":"E1451","volume":"113"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AML79051.1"}],"value":"VTUS_2051521","type":"STRAIN"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AML79051.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"KU701447","properties":[{"key":"ProteinId","value":"AML79051.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"AlphaFoldDB","id":"A0A126X2Z0","properties":[{"key":"Description","value":"-"}]},{"database":"GO","id":"GO:0005829","properties":[{"key":"GoTerm","value":"C:cytosol"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:0005634","properties":[{"key":"GoTerm","value":"C:nucleus"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0019005","properties":[{"key":"GoTerm","value":"C:SCF ubiquitin ligase complex"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:0007623","properties":[{"key":"GoTerm","value":"P:circadian rhythm"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:0009637","properties":[{"key":"GoTerm","value":"P:response to blue light"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"CDD","id":"cd22154","properties":[{"key":"EntryName","value":"F-box_AtADO-like"},{"key":"MatchStatus","value":"1"}]},{"database":"CDD","id":"cd00130","properties":[{"key":"EntryName","value":"PAS"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.120.10.80:FF:000026","properties":[{"key":"EntryName","value":"Putative LOV domain-containing protein"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.120.10.80","properties":[{"key":"EntryName","value":"Kelch-type beta propeller"},{"key":"MatchStatus","value":"2"}]},{"database":"Gene3D","id":"3.30.450.20","properties":[{"key":"EntryName","value":"PAS domain"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR036047","properties":[{"key":"EntryName","value":"F-box-like_dom_sf"}]},{"database":"InterPro","id":"IPR001810","properties":[{"key":"EntryName","value":"F-box_dom"}]},{"database":"InterPro","id":"IPR015915","properties":[{"key":"EntryName","value":"Kelch-typ_b-propeller"}]},{"database":"InterPro","id":"IPR011498","properties":[{"key":"EntryName","value":"Kelch_2"}]},{"database":"InterPro","id":"IPR000014","properties":[{"key":"EntryName","value":"PAS"}]},{"database":"InterPro","id":"IPR035965","properties":[{"key":"EntryName","value":"PAS-like_dom_sf"}]},{"database":"PANTHER","id":"PTHR46175:SF2","properties":[{"key":"EntryName","value":"ADAGIO PROTEIN 3"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR46175","properties":[{"key":"EntryName","value":"BACTERIOOPSIN TRANSCRIPTIONAL ACTIVATOR"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF12937","properties":[{"key":"EntryName","value":"F-box-like"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF07646","properties":[{"key":"EntryName","value":"Kelch_2"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF24681","properties":[{"key":"EntryName","value":"Kelch_KLHDC2_KLHL20_DRC7"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF13426","properties":[{"key":"EntryName","value":"PAS_9"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF81383","properties":[{"key":"EntryName","value":"F-box domain"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF117281","properties":[{"key":"EntryName","value":"Kelch motif"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF55785","properties":[{"key":"EntryName","value":"PYP-like sensor domain (PAS domain)"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50112","properties":[{"key":"EntryName","value":"PAS"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MEMEGRRGAEVSKGSSSGKKRLKFSMEEDDMDQEVRKEKEEAADVISPFYYQPGTWPPPSFIVADALEPDFPIIYVNAVFEKATGYRADEVLGRNCRFLQFRDPWAQRRHPLVDPMVVCEIHRCLEEGVEFQGELLNFRKDGTPLVNRLRLMPMGDDGIISQVIGIQLYFESNIDLNNETYPVYKQTSLCKINPENMNFPASELTCCIQHHSCHCGILQLCDEVLAHNILSRLTPRDIASVGSVCTRMHKLTKNENLRKMVCQNAWGREVTGKLELSIKSSGWARLARELTTLEAMEWKKFTVGGKIEPSRCNFSACAVGNRLVLFGGEGVNMQPMDDTFVLNIEEENPEWRRVKVASSPPGRWGHTLSCLNGSWLVVFGGCGRQGLLNDMFVLNLDSPHPAWTEVVGEAPPPPRSWHSACTLNVSKLVVSGGCTDAGVLLGDTFLLDFTNEKPVWREISTKWQPPSRLGHSLSVYGRTKILMFGGMAKSGSLRLRSCDTYLIDLGEVEPQWRQLETNGLPGATPPPRLDHVAVSLPCGRIIIFGGSIAGLHSPSQLFLLDPPEEKPTWRMLNVPGQPPKFAWGHSTCVVGGTRALVLGGHTGEEWILNELNELCLASV","length":619,"molWeight":68928,"crc64":"5184319B19EB9E07","md5":"AD4FDC5AF30D8F9AE2608589C8EE1DFD"},"extraAttributes":{"countByCommentType":{"PATHWAY":1,"SUBCELLULAR LOCATION":1,"SIMILARITY":1},"countByFeatureType":{"Domain":1,"Region":1,"Compositional bias":1},"uniParcId":"UPI00078B584E"}}]}