{"results":[{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0A126WWR5","uniProtkbId":"A0A126WWR5_ERICD","entryAudit":{"firstPublicDate":"2016-05-11","lastAnnotationUpdateDate":"2026-11-04","lastSequenceUpdateDate":"2016-05-11","entryVersion":40,"sequenceVersion":1},"annotationScore":3.0,"organism":{"scientificName":"Erigeron canadensis","commonName":"Canadian horseweed","synonyms":["Conyza canadensis"],"taxonId":72917,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AML76748.1"}],"lineage":["Eukaryota","Viridiplantae","Streptophyta","Embryophyta","Tracheophyta","Spermatophyta","Magnoliopsida","eudicotyledons","Gunneridae","Pentapetalae","asterids","campanulids","Asterales","Asteraceae","Asteroideae","Astereae","North American clade","Conyzinae","Erigeron"]},"proteinExistence":"2: Evidence at transcript level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00012513"}],"value":"non-specific serine/threonine protein kinase"},"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00012513"}],"value":"2.7.11.1"}]}},"comments":[{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:17989"},{"database":"Rhea","id":"RHEA-COMP:9863"},{"database":"Rhea","id":"RHEA-COMP:11604"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:29999"},{"database":"ChEBI","id":"CHEBI:30616"},{"database":"ChEBI","id":"CHEBI:83421"},{"database":"ChEBI","id":"CHEBI:456216"}],"ecNumber":"2.7.11.1","evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00048679"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU10027"}]}},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:46608"},{"database":"Rhea","id":"RHEA-COMP:11060"},{"database":"Rhea","id":"RHEA-COMP:11605"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:30013"},{"database":"ChEBI","id":"CHEBI:30616"},{"database":"ChEBI","id":"CHEBI:61977"},{"database":"ChEBI","id":"CHEBI:456216"}],"ecNumber":"2.7.11.1","evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00047899"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU10027"}]}},{"commentType":"COFACTOR","cofactors":[{"name":"FMN","evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00001917"}],"cofactorCrossReference":{"database":"ChEBI","id":"CHEBI:58210"}}]},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004202"}],"value":"Cell membrane","id":"SL-0039"},"topology":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004202"}],"value":"Peripheral membrane protein","id":"SL-9903"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00009903"}],"value":"Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family"}],"commentType":"SIMILARITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00159"}],"value":"Belongs to the protein kinase superfamily. Ser/Thr protein kinase family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Domain","location":{"start":{"value":95,"modifier":"EXACT"},"end":{"value":168,"modifier":"EXACT"}},"description":"PAS","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50112"}]},{"type":"Domain","location":{"start":{"value":169,"modifier":"EXACT"},"end":{"value":223,"modifier":"EXACT"}},"description":"PAC","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50113"}]},{"type":"Domain","location":{"start":{"value":367,"modifier":"EXACT"},"end":{"value":440,"modifier":"EXACT"}},"description":"PAS","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50112"}]},{"type":"Domain","location":{"start":{"value":441,"modifier":"EXACT"},"end":{"value":495,"modifier":"EXACT"}},"description":"PAC","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50113"}]},{"type":"Domain","location":{"start":{"value":568,"modifier":"EXACT"},"end":{"value":854,"modifier":"EXACT"}},"description":"Protein kinase","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50011"}]},{"type":"Region","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":40,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":66,"modifier":"EXACT"},"end":{"value":93,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":284,"modifier":"EXACT"},"end":{"value":340,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":726,"modifier":"EXACT"},"end":{"value":750,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":13,"modifier":"EXACT"}},"description":"Polar residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":76,"modifier":"EXACT"},"end":{"value":90,"modifier":"EXACT"}},"description":"Low complexity","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":303,"modifier":"EXACT"},"end":{"value":313,"modifier":"EXACT"}},"description":"Polar residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Active site","location":{"start":{"value":693,"modifier":"EXACT"},"end":{"value":693,"modifier":"EXACT"}},"description":"Proton acceptor","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU10027"}]},{"type":"Binding site","location":{"start":{"value":597,"modifier":"EXACT"},"end":{"value":597,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:30616"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU10141"}],"ligand":{"name":"ATP","id":"ChEBI:CHEBI:30616"}}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022840"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU10141"}],"id":"KW-0067","category":"Ligand","name":"ATP-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022991"}],"id":"KW-0157","category":"Ligand","name":"Chromophore"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022630"}],"id":"KW-0285","category":"Ligand","name":"Flavoprotein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022643"}],"id":"KW-0288","category":"Ligand","name":"FMN"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022777"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00159"}],"id":"KW-0418","category":"Molecular function","name":"Kinase"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022741"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU10141"}],"id":"KW-0547","category":"Ligand","name":"Nucleotide-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022543"}],"id":"KW-0600","category":"Molecular function","name":"Photoreceptor protein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023170"}],"id":"KW-0675","category":"Molecular function","name":"Receptor"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022737"}],"id":"KW-0677","category":"Domain","name":"Repeat"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022606"}],"id":"KW-0716","category":"Biological process","name":"Sensory transduction"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022527"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00159"}],"id":"KW-0723","category":"Molecular function","name":"Serine/threonine-protein kinase"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022679"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00159"}],"id":"KW-0808","category":"Molecular function","name":"Transferase"}],"references":[{"referenceNumber":1,"citation":{"id":"26929367","citationType":"journal article","authors":["Glantz S.T.","Carpenter E.J.","Melkonian M.","Gardner K.H.","Boyden E.S.","Wong G.K.","Chow B.Y."],"citationCrossReferences":[{"database":"PubMed","id":"26929367"},{"database":"DOI","id":"10.1073/pnas.1509428113"}],"title":"Functional and topological diversity of LOV domain photoreceptors.","publicationDate":"2016","journal":"Proc. Natl. Acad. Sci. U.S.A.","firstPage":"E1442","lastPage":"E1451","volume":"113"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AML76748.1"}],"value":"DESP_2108092","type":"STRAIN"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AML76748.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"KU698637","properties":[{"key":"ProteinId","value":"AML76748.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"AlphaFoldDB","id":"A0A126WWR5","properties":[{"key":"Description","value":"-"}]},{"database":"GO","id":"GO:0005886","properties":[{"key":"GoTerm","value":"C:plasma membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0005524","properties":[{"key":"GoTerm","value":"F:ATP binding"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniRule"}]},{"database":"GO","id":"GO:0009882","properties":[{"key":"GoTerm","value":"F:blue light photoreceptor activity"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0010181","properties":[{"key":"GoTerm","value":"F:FMN binding"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0042802","properties":[{"key":"GoTerm","value":"F:identical protein binding"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0004674","properties":[{"key":"GoTerm","value":"F:protein serine/threonine kinase activity"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniRule"}]},{"database":"GO","id":"GO:0009902","properties":[{"key":"GoTerm","value":"P:chloroplast relocation"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0007623","properties":[{"key":"GoTerm","value":"P:circadian rhythm"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0009638","properties":[{"key":"GoTerm","value":"P:phototropism"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"CDD","id":"cd00130","properties":[{"key":"EntryName","value":"PAS"},{"key":"MatchStatus","value":"2"}]},{"database":"CDD","id":"cd05574","properties":[{"key":"EntryName","value":"STKc_phototropin_like"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.30.200.20:FF:000133","properties":[{"key":"EntryName","value":"LOV domain-containing protein"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.30.450.20:FF:000002","properties":[{"key":"EntryName","value":"LOV domain-containing protein"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.10.510.10:FF:000265","properties":[{"key":"EntryName","value":"Putative LOV domain-containing protein"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.30.450.20:FF:000036","properties":[{"key":"EntryName","value":"Putative LOV domain-containing protein"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.30.450.20","properties":[{"key":"EntryName","value":"PAS domain"},{"key":"MatchStatus","value":"2"}]},{"database":"Gene3D","id":"3.30.200.20","properties":[{"key":"EntryName","value":"Phosphorylase Kinase, domain 1"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.10.510.10","properties":[{"key":"EntryName","value":"Transferase(Phosphotransferase) domain 1"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR011009","properties":[{"key":"EntryName","value":"Kinase-like_dom_sf"}]},{"database":"InterPro","id":"IPR001610","properties":[{"key":"EntryName","value":"PAC"}]},{"database":"InterPro","id":"IPR000014","properties":[{"key":"EntryName","value":"PAS"}]},{"database":"InterPro","id":"IPR000700","properties":[{"key":"EntryName","value":"PAS-assoc_C"}]},{"database":"InterPro","id":"IPR035965","properties":[{"key":"EntryName","value":"PAS-like_dom_sf"}]},{"database":"InterPro","id":"IPR000719","properties":[{"key":"EntryName","value":"Prot_kinase_dom"}]},{"database":"InterPro","id":"IPR017441","properties":[{"key":"EntryName","value":"Protein_kinase_ATP_BS"}]},{"database":"InterPro","id":"IPR008271","properties":[{"key":"EntryName","value":"Ser/Thr_kinase_AS"}]},{"database":"NCBIfam","id":"TIGR00229","properties":[{"key":"EntryName","value":"sensory_box"},{"key":"MatchStatus","value":"2"}]},{"database":"PANTHER","id":"PTHR45637","properties":[{"key":"EntryName","value":"FLIPPASE KINASE 1-RELATED"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF13426","properties":[{"key":"EntryName","value":"PAS_9"},{"key":"MatchStatus","value":"2"}]},{"database":"Pfam","id":"PF00069","properties":[{"key":"EntryName","value":"Pkinase"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00086","properties":[{"key":"EntryName","value":"PAC"},{"key":"MatchStatus","value":"2"}]},{"database":"SMART","id":"SM00091","properties":[{"key":"EntryName","value":"PAS"},{"key":"MatchStatus","value":"2"}]},{"database":"SMART","id":"SM00220","properties":[{"key":"EntryName","value":"S_TKc"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF56112","properties":[{"key":"EntryName","value":"Protein kinase-like (PK-like)"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF55785","properties":[{"key":"EntryName","value":"PYP-like sensor domain (PAS domain)"},{"key":"MatchStatus","value":"2"}]},{"database":"PROSITE","id":"PS50113","properties":[{"key":"EntryName","value":"PAC"},{"key":"MatchStatus","value":"2"}]},{"database":"PROSITE","id":"PS50112","properties":[{"key":"EntryName","value":"PAS"},{"key":"MatchStatus","value":"2"}]},{"database":"PROSITE","id":"PS00107","properties":[{"key":"EntryName","value":"PROTEIN_KINASE_ATP"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50011","properties":[{"key":"EntryName","value":"PROTEIN_KINASE_DOM"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00108","properties":[{"key":"EntryName","value":"PROTEIN_KINASE_ST"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MERSNAESSTTGELINKWMAFDQSSNQNKPPIARVTPPEDDEYDITKIAERTAEWPGGATIANVIGDEERNKRRSSSASWRSSRDNSLSSVEPRVSQDLKDALATLQQTFVVSDATKPDCPIMYASSGFFTMTGYSSKEVIGRNCRFLQGKETDQKEVDKIRHAVKTGTSYCGRLYNYKKDGTPFWNLLTVTPIKDENGNTIKFIGMQVEVSKYTEGVNEKELRPNGLPKSLIRYDARQKETALGSIVEVVQTVERPRNQYRSSLTEIQEKIVESPLVGPAENLSLYTPGRETPLSDIKSDLTRTSSWNSSNPKSRKSIRSSLMGFKGRSSTNEPTPPIIEPEELMTKDIARTDSWDRAERYRDIRQGIDLATTLERIEKNFVITDPRLPDNPIIFASDSFLELTEFTREEILGRNCRFLQGPETDQGTVDKIRAAIREQREITVQLINYTKSGKKFWNLFHLQPMRDQKGELQYFIGVQLDGSGHVEPLRNRLSDTTEKQSAKLVKATAENVDEAVRELPDANLRPEDLWAIHSQSVSPRPHRRYNTSWKAIQKITAGGEIIGLGHFKPIRPLGSGDTGSVHLVELKGTGELFAMKAMDKSVMLNRNKVHRACIEREIIALLDHPFLPTLYTSFQTPTHVCLITDFCPGGELFALLDKQPLKLFKEDSARFYAAEVVIGLEYLHCLGIIYRDLKPENILLQTDGHVVLSDFDLSFRTQCKPQVIKHAPSKRRRSRSQPPPTFVAEPSTQSNSFVGTEEYIAPEIITGAGHSSAIDWWAVGILLYEMLYGRTPFRGKNRQKTFANILHKDLTFPSSIPVSLAARQMIHALLNRDPSARLGSNGGSSEIKEHAFFRGINWPLIRCMTPPPLDAPLELIEKDPNTKDVQWEDGALLDNSLDIF","length":901,"molWeight":101558,"crc64":"FFD81AFA124F115F","md5":"44B6FBB11E4D81C4655223B9D665FE2E"},"extraAttributes":{"countByCommentType":{"CATALYTIC ACTIVITY":2,"COFACTOR":1,"SUBCELLULAR LOCATION":1,"SIMILARITY":2},"countByFeatureType":{"Domain":5,"Region":4,"Compositional bias":3,"Active site":1,"Binding site":1},"uniParcId":"UPI00078E04EF"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0A126WZC8","uniProtkbId":"A0A126WZC8_ERICD","entryAudit":{"firstPublicDate":"2016-05-11","lastAnnotationUpdateDate":"2026-11-04","lastSequenceUpdateDate":"2016-05-11","entryVersion":41,"sequenceVersion":1},"annotationScore":3.0,"organism":{"scientificName":"Erigeron canadensis","commonName":"Canadian horseweed","synonyms":["Conyza canadensis"],"taxonId":72917,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AML77862.1"}],"lineage":["Eukaryota","Viridiplantae","Streptophyta","Embryophyta","Tracheophyta","Spermatophyta","Magnoliopsida","eudicotyledons","Gunneridae","Pentapetalae","asterids","campanulids","Asterales","Asteraceae","Asteroideae","Astereae","North American clade","Conyzinae","Erigeron"]},"proteinExistence":"2: Evidence at transcript level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00012513"}],"value":"non-specific serine/threonine protein kinase"},"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00012513"}],"value":"2.7.11.1"}]}},"comments":[{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:17989"},{"database":"Rhea","id":"RHEA-COMP:9863"},{"database":"Rhea","id":"RHEA-COMP:11604"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:29999"},{"database":"ChEBI","id":"CHEBI:30616"},{"database":"ChEBI","id":"CHEBI:83421"},{"database":"ChEBI","id":"CHEBI:456216"}],"ecNumber":"2.7.11.1","evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00048679"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU10027"}]}},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:46608"},{"database":"Rhea","id":"RHEA-COMP:11060"},{"database":"Rhea","id":"RHEA-COMP:11605"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:30013"},{"database":"ChEBI","id":"CHEBI:30616"},{"database":"ChEBI","id":"CHEBI:61977"},{"database":"ChEBI","id":"CHEBI:456216"}],"ecNumber":"2.7.11.1","evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00047899"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU10027"}]}},{"commentType":"COFACTOR","cofactors":[{"name":"FMN","evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00001917"}],"cofactorCrossReference":{"database":"ChEBI","id":"CHEBI:58210"}}]},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004202"}],"value":"Cell membrane","id":"SL-0039"},"topology":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004202"}],"value":"Peripheral membrane protein","id":"SL-9903"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00009903"}],"value":"Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family"}],"commentType":"SIMILARITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00159"}],"value":"Belongs to the protein kinase superfamily. Ser/Thr protein kinase family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Domain","location":{"start":{"value":193,"modifier":"EXACT"},"end":{"value":265,"modifier":"EXACT"}},"description":"PAS","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50112"}]},{"type":"Domain","location":{"start":{"value":267,"modifier":"EXACT"},"end":{"value":321,"modifier":"EXACT"}},"description":"PAC","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50113"}]},{"type":"Domain","location":{"start":{"value":500,"modifier":"EXACT"},"end":{"value":569,"modifier":"EXACT"}},"description":"PAS","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50112"}]},{"type":"Domain","location":{"start":{"value":570,"modifier":"EXACT"},"end":{"value":624,"modifier":"EXACT"}},"description":"PAC","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50113"}]},{"type":"Domain","location":{"start":{"value":697,"modifier":"EXACT"},"end":{"value":986,"modifier":"EXACT"}},"description":"Protein kinase","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50011"}]},{"type":"Region","location":{"start":{"value":26,"modifier":"EXACT"},"end":{"value":73,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":138,"modifier":"EXACT"},"end":{"value":190,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":351,"modifier":"EXACT"},"end":{"value":492,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":30,"modifier":"EXACT"},"end":{"value":40,"modifier":"EXACT"}},"description":"Polar residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":56,"modifier":"EXACT"},"end":{"value":68,"modifier":"EXACT"}},"description":"Pro residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":153,"modifier":"EXACT"},"end":{"value":169,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":371,"modifier":"EXACT"},"end":{"value":381,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":426,"modifier":"EXACT"},"end":{"value":443,"modifier":"EXACT"}},"description":"Basic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":462,"modifier":"EXACT"},"end":{"value":473,"modifier":"EXACT"}},"description":"Acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":474,"modifier":"EXACT"},"end":{"value":492,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Active site","location":{"start":{"value":822,"modifier":"EXACT"},"end":{"value":822,"modifier":"EXACT"}},"description":"Proton acceptor","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU10027"}]},{"type":"Binding site","location":{"start":{"value":726,"modifier":"EXACT"},"end":{"value":726,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:30616"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU10141"}],"ligand":{"name":"ATP","id":"ChEBI:CHEBI:30616"}}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022840"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU10141"}],"id":"KW-0067","category":"Ligand","name":"ATP-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022991"}],"id":"KW-0157","category":"Ligand","name":"Chromophore"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022630"}],"id":"KW-0285","category":"Ligand","name":"Flavoprotein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022643"}],"id":"KW-0288","category":"Ligand","name":"FMN"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022777"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00159"}],"id":"KW-0418","category":"Molecular function","name":"Kinase"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022741"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU10141"}],"id":"KW-0547","category":"Ligand","name":"Nucleotide-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022543"}],"id":"KW-0600","category":"Molecular function","name":"Photoreceptor protein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023170"}],"id":"KW-0675","category":"Molecular function","name":"Receptor"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022737"}],"id":"KW-0677","category":"Domain","name":"Repeat"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022606"}],"id":"KW-0716","category":"Biological process","name":"Sensory transduction"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022527"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00159"}],"id":"KW-0723","category":"Molecular function","name":"Serine/threonine-protein kinase"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022679"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00159"}],"id":"KW-0808","category":"Molecular function","name":"Transferase"}],"references":[{"referenceNumber":1,"citation":{"id":"26929367","citationType":"journal article","authors":["Glantz S.T.","Carpenter E.J.","Melkonian M.","Gardner K.H.","Boyden E.S.","Wong G.K.","Chow B.Y."],"citationCrossReferences":[{"database":"PubMed","id":"26929367"},{"database":"DOI","id":"10.1073/pnas.1509428113"}],"title":"Functional and topological diversity of LOV domain photoreceptors.","publicationDate":"2016","journal":"Proc. Natl. Acad. Sci. U.S.A.","firstPage":"E1442","lastPage":"E1451","volume":"113"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AML77862.1"}],"value":"MHYG_2087420","type":"STRAIN"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AML79222.1"}],"value":"WSYE_2067470","type":"STRAIN"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AML77862.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"KU699997","properties":[{"key":"ProteinId","value":"AML77862.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"KU701651","properties":[{"key":"ProteinId","value":"AML79222.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"RefSeq","id":"XP_043609390.1","properties":[{"key":"NucleotideSequenceId","value":"XM_043753455.1"}]},{"database":"AlphaFoldDB","id":"A0A126WZC8","properties":[{"key":"Description","value":"-"}]},{"database":"GeneID","id":"122581265","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"ecad:122581265","properties":[{"key":"Description","value":"-"}]},{"database":"OrthoDB","id":"432483at2759","properties":[{"key":"Description","value":"-"}]},{"database":"GO","id":"GO:0005886","properties":[{"key":"GoTerm","value":"C:plasma membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0005524","properties":[{"key":"GoTerm","value":"F:ATP binding"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniRule"}]},{"database":"GO","id":"GO:0009882","properties":[{"key":"GoTerm","value":"F:blue light photoreceptor activity"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0010181","properties":[{"key":"GoTerm","value":"F:FMN binding"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0042802","properties":[{"key":"GoTerm","value":"F:identical protein binding"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0004674","properties":[{"key":"GoTerm","value":"F:protein serine/threonine kinase activity"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniRule"}]},{"database":"GO","id":"GO:0009902","properties":[{"key":"GoTerm","value":"P:chloroplast relocation"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0007623","properties":[{"key":"GoTerm","value":"P:circadian rhythm"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0009638","properties":[{"key":"GoTerm","value":"P:phototropism"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"CDD","id":"cd00130","properties":[{"key":"EntryName","value":"PAS"},{"key":"MatchStatus","value":"2"}]},{"database":"CDD","id":"cd05574","properties":[{"key":"EntryName","value":"STKc_phototropin_like"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.30.200.20:FF:000133","properties":[{"key":"EntryName","value":"LOV domain-containing protein"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.30.450.20:FF:000002","properties":[{"key":"EntryName","value":"LOV domain-containing protein"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.10.510.10:FF:000265","properties":[{"key":"EntryName","value":"Putative LOV domain-containing protein"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.30.450.20:FF:000036","properties":[{"key":"EntryName","value":"Putative LOV domain-containing protein"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.30.450.20","properties":[{"key":"EntryName","value":"PAS domain"},{"key":"MatchStatus","value":"2"}]},{"database":"Gene3D","id":"3.30.200.20","properties":[{"key":"EntryName","value":"Phosphorylase Kinase, domain 1"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.10.510.10","properties":[{"key":"EntryName","value":"Transferase(Phosphotransferase) domain 1"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR011009","properties":[{"key":"EntryName","value":"Kinase-like_dom_sf"}]},{"database":"InterPro","id":"IPR001610","properties":[{"key":"EntryName","value":"PAC"}]},{"database":"InterPro","id":"IPR000014","properties":[{"key":"EntryName","value":"PAS"}]},{"database":"InterPro","id":"IPR000700","properties":[{"key":"EntryName","value":"PAS-assoc_C"}]},{"database":"InterPro","id":"IPR035965","properties":[{"key":"EntryName","value":"PAS-like_dom_sf"}]},{"database":"InterPro","id":"IPR000719","properties":[{"key":"EntryName","value":"Prot_kinase_dom"}]},{"database":"InterPro","id":"IPR017441","properties":[{"key":"EntryName","value":"Protein_kinase_ATP_BS"}]},{"database":"InterPro","id":"IPR008271","properties":[{"key":"EntryName","value":"Ser/Thr_kinase_AS"}]},{"database":"NCBIfam","id":"TIGR00229","properties":[{"key":"EntryName","value":"sensory_box"},{"key":"MatchStatus","value":"2"}]},{"database":"PANTHER","id":"PTHR45637","properties":[{"key":"EntryName","value":"FLIPPASE KINASE 1-RELATED"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF13426","properties":[{"key":"EntryName","value":"PAS_9"},{"key":"MatchStatus","value":"2"}]},{"database":"Pfam","id":"PF00069","properties":[{"key":"EntryName","value":"Pkinase"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00086","properties":[{"key":"EntryName","value":"PAC"},{"key":"MatchStatus","value":"2"}]},{"database":"SMART","id":"SM00091","properties":[{"key":"EntryName","value":"PAS"},{"key":"MatchStatus","value":"2"}]},{"database":"SMART","id":"SM00220","properties":[{"key":"EntryName","value":"S_TKc"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF56112","properties":[{"key":"EntryName","value":"Protein kinase-like (PK-like)"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF55785","properties":[{"key":"EntryName","value":"PYP-like sensor domain (PAS domain)"},{"key":"MatchStatus","value":"2"}]},{"database":"PROSITE","id":"PS50113","properties":[{"key":"EntryName","value":"PAC"},{"key":"MatchStatus","value":"2"}]},{"database":"PROSITE","id":"PS50112","properties":[{"key":"EntryName","value":"PAS"},{"key":"MatchStatus","value":"2"}]},{"database":"PROSITE","id":"PS00107","properties":[{"key":"EntryName","value":"PROTEIN_KINASE_ATP"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50011","properties":[{"key":"EntryName","value":"PROTEIN_KINASE_DOM"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00108","properties":[{"key":"EntryName","value":"PROTEIN_KINASE_ST"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MEQKEHAQNKPTPLFQLAQRDVRGSLEVFNPSSHETTAPFRSQPAWRSWAESPQNNPEPPPPSPPPPSADIIINDHNVGLTASHSGRLPADEINKSWMALKDPYPPQLPSFAAAAPQSPGGVMGAAEQRAAEWGLVLQKDTETGKPQGVKVRTSGEDSNAKPGSNRRDSGNSVQSSSDISDDGLGKERGFPRVSEDLKDALSTFQQTFVVSDATKPDYPILYASAGFFKMTGYTSKEVIGRNCRFLQGADTDPEDVAKIRDALSKGTTYCGRLLNYKKDGSPFWNLLTVSPIKDESGKTLKFIGMQVEVSKHTEGTKEKTLRPNGLPESLIRYDARQKDMATSSVTELVEAVKRPRSVSESTNRHPFAMDSRNKTNQEKNDVLSFGRRKSAETMFPPPPPPHRRNSHAGVRTITTMQSIHEVPEKKQKKSKRISFMGIKKKNRKSSDEFDDGFDGDINIQDTDGEGDDDDDAFEPQRDDSRPESLDDKVRKKEMRKGIDLATTLERIEKNFVITDPRLPDNPIIFASDSFLELTEYSREEILGRNCRFLQGPETDPSTVKKIREAIDNQREVTVQLINYTKTGKKFWNLFHLQPMRDQKGEVQYFIGVQLDGSQHVEPLHNCIPETTAKDGALLVKETAENVDVAVRELPDANMTPEDLWAKHSNTVHPKPHRKDTSAWKAILKVMESGEKLGLKHFKPIKPLGSGDTGSVHLVELCGTSELFAMKAMDKGVMINRNKVHRACAERDILDVLDHPFLPALYASFQTPTHVCLITDYCPGGELFMLLDRQPMKVLKEDAVRFYAAEVLVALEYLHCQGIIYRDLKPENVLIQSTGHVALTDFDLSCLTSCKPQLLIPEISEKKKKKHHKGHQNPIFMAEPVRASNSFVGTEEYIAPEIISGAGHSSAVDWWALGILLYEMFYGYTPFRGKTRQRTFANVLHKDLKFPGSIAVSLPAKQLIYRLLHRDPKNRLGSHEGASEVKRHPFFRGINWALIRCQNPPKLETPVFGANADQNIKEVDPGLKDLENNVF","length":1030,"molWeight":115334,"crc64":"16A56D81E44434B9","md5":"B85705465C518175D77B87FDD8460848"},"extraAttributes":{"countByCommentType":{"CATALYTIC ACTIVITY":2,"COFACTOR":1,"SUBCELLULAR LOCATION":1,"SIMILARITY":2},"countByFeatureType":{"Domain":5,"Region":3,"Compositional bias":7,"Active site":1,"Binding site":1},"uniParcId":"UPI00078D6884"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0A126WZE4","uniProtkbId":"A0A126WZE4_ERICD","entryAudit":{"firstPublicDate":"2016-05-11","lastAnnotationUpdateDate":"2026-11-04","lastSequenceUpdateDate":"2016-05-11","entryVersion":40,"sequenceVersion":1},"annotationScore":3.0,"organism":{"scientificName":"Erigeron canadensis","commonName":"Canadian horseweed","synonyms":["Conyza canadensis"],"taxonId":72917,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AML77859.1"}],"lineage":["Eukaryota","Viridiplantae","Streptophyta","Embryophyta","Tracheophyta","Spermatophyta","Magnoliopsida","eudicotyledons","Gunneridae","Pentapetalae","asterids","campanulids","Asterales","Asteraceae","Asteroideae","Astereae","North American clade","Conyzinae","Erigeron"]},"proteinExistence":"2: Evidence at transcript level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00012513"}],"value":"non-specific serine/threonine protein kinase"},"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00012513"}],"value":"2.7.11.1"}]}},"comments":[{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:17989"},{"database":"Rhea","id":"RHEA-COMP:9863"},{"database":"Rhea","id":"RHEA-COMP:11604"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:29999"},{"database":"ChEBI","id":"CHEBI:30616"},{"database":"ChEBI","id":"CHEBI:83421"},{"database":"ChEBI","id":"CHEBI:456216"}],"ecNumber":"2.7.11.1","evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00048679"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU10027"}]}},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:46608"},{"database":"Rhea","id":"RHEA-COMP:11060"},{"database":"Rhea","id":"RHEA-COMP:11605"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:30013"},{"database":"ChEBI","id":"CHEBI:30616"},{"database":"ChEBI","id":"CHEBI:61977"},{"database":"ChEBI","id":"CHEBI:456216"}],"ecNumber":"2.7.11.1","evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00047899"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU10027"}]}},{"commentType":"COFACTOR","cofactors":[{"name":"FMN","evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00001917"}],"cofactorCrossReference":{"database":"ChEBI","id":"CHEBI:58210"}}]},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004202"}],"value":"Cell membrane","id":"SL-0039"},"topology":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004202"}],"value":"Peripheral membrane protein","id":"SL-9903"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00009903"}],"value":"Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family"}],"commentType":"SIMILARITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00159"}],"value":"Belongs to the protein kinase superfamily. Ser/Thr protein kinase family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Domain","location":{"start":{"value":95,"modifier":"EXACT"},"end":{"value":168,"modifier":"EXACT"}},"description":"PAS","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50112"}]},{"type":"Domain","location":{"start":{"value":169,"modifier":"EXACT"},"end":{"value":223,"modifier":"EXACT"}},"description":"PAC","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50113"}]},{"type":"Domain","location":{"start":{"value":367,"modifier":"EXACT"},"end":{"value":440,"modifier":"EXACT"}},"description":"PAS","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50112"}]},{"type":"Domain","location":{"start":{"value":441,"modifier":"EXACT"},"end":{"value":495,"modifier":"EXACT"}},"description":"PAC","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50113"}]},{"type":"Domain","location":{"start":{"value":568,"modifier":"EXACT"},"end":{"value":854,"modifier":"EXACT"}},"description":"Protein kinase","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50011"}]},{"type":"Region","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":41,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":58,"modifier":"EXACT"},"end":{"value":93,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":288,"modifier":"EXACT"},"end":{"value":319,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":726,"modifier":"EXACT"},"end":{"value":750,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":14,"modifier":"EXACT"}},"description":"Polar residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":76,"modifier":"EXACT"},"end":{"value":90,"modifier":"EXACT"}},"description":"Low complexity","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":303,"modifier":"EXACT"},"end":{"value":312,"modifier":"EXACT"}},"description":"Polar residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Active site","location":{"start":{"value":693,"modifier":"EXACT"},"end":{"value":693,"modifier":"EXACT"}},"description":"Proton acceptor","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU10027"}]},{"type":"Binding site","location":{"start":{"value":597,"modifier":"EXACT"},"end":{"value":597,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:30616"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU10141"}],"ligand":{"name":"ATP","id":"ChEBI:CHEBI:30616"}}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022840"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU10141"}],"id":"KW-0067","category":"Ligand","name":"ATP-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022991"}],"id":"KW-0157","category":"Ligand","name":"Chromophore"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022630"}],"id":"KW-0285","category":"Ligand","name":"Flavoprotein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022643"}],"id":"KW-0288","category":"Ligand","name":"FMN"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022777"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00159"}],"id":"KW-0418","category":"Molecular function","name":"Kinase"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022741"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU10141"}],"id":"KW-0547","category":"Ligand","name":"Nucleotide-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022543"}],"id":"KW-0600","category":"Molecular function","name":"Photoreceptor protein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023170"}],"id":"KW-0675","category":"Molecular function","name":"Receptor"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022737"}],"id":"KW-0677","category":"Domain","name":"Repeat"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022606"}],"id":"KW-0716","category":"Biological process","name":"Sensory transduction"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022527"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00159"}],"id":"KW-0723","category":"Molecular function","name":"Serine/threonine-protein kinase"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022679"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00159"}],"id":"KW-0808","category":"Molecular function","name":"Transferase"}],"references":[{"referenceNumber":1,"citation":{"id":"26929367","citationType":"journal article","authors":["Glantz S.T.","Carpenter E.J.","Melkonian M.","Gardner K.H.","Boyden E.S.","Wong G.K.","Chow B.Y."],"citationCrossReferences":[{"database":"PubMed","id":"26929367"},{"database":"DOI","id":"10.1073/pnas.1509428113"}],"title":"Functional and topological diversity of LOV domain photoreceptors.","publicationDate":"2016","journal":"Proc. Natl. Acad. Sci. U.S.A.","firstPage":"E1442","lastPage":"E1451","volume":"113"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AML77859.1"}],"value":"MHYG_2003634","type":"STRAIN"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AML78044.1"}],"value":"NUSE_2002015","type":"STRAIN"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AML77859.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"KU699994","properties":[{"key":"ProteinId","value":"AML77859.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"KU700218","properties":[{"key":"ProteinId","value":"AML78044.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"AlphaFoldDB","id":"A0A126WZE4","properties":[{"key":"Description","value":"-"}]},{"database":"GO","id":"GO:0005886","properties":[{"key":"GoTerm","value":"C:plasma membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0005524","properties":[{"key":"GoTerm","value":"F:ATP binding"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniRule"}]},{"database":"GO","id":"GO:0009882","properties":[{"key":"GoTerm","value":"F:blue light photoreceptor activity"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0010181","properties":[{"key":"GoTerm","value":"F:FMN binding"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0042802","properties":[{"key":"GoTerm","value":"F:identical protein binding"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0004674","properties":[{"key":"GoTerm","value":"F:protein serine/threonine kinase activity"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniRule"}]},{"database":"GO","id":"GO:0009902","properties":[{"key":"GoTerm","value":"P:chloroplast relocation"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0007623","properties":[{"key":"GoTerm","value":"P:circadian rhythm"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0009638","properties":[{"key":"GoTerm","value":"P:phototropism"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"CDD","id":"cd00130","properties":[{"key":"EntryName","value":"PAS"},{"key":"MatchStatus","value":"2"}]},{"database":"CDD","id":"cd05574","properties":[{"key":"EntryName","value":"STKc_phototropin_like"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.30.200.20:FF:000133","properties":[{"key":"EntryName","value":"LOV domain-containing protein"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.30.450.20:FF:000002","properties":[{"key":"EntryName","value":"LOV domain-containing protein"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.10.510.10:FF:000265","properties":[{"key":"EntryName","value":"Putative LOV domain-containing protein"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.30.450.20:FF:000036","properties":[{"key":"EntryName","value":"Putative LOV domain-containing protein"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.30.450.20","properties":[{"key":"EntryName","value":"PAS domain"},{"key":"MatchStatus","value":"2"}]},{"database":"Gene3D","id":"3.30.200.20","properties":[{"key":"EntryName","value":"Phosphorylase Kinase, domain 1"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.10.510.10","properties":[{"key":"EntryName","value":"Transferase(Phosphotransferase) domain 1"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR011009","properties":[{"key":"EntryName","value":"Kinase-like_dom_sf"}]},{"database":"InterPro","id":"IPR001610","properties":[{"key":"EntryName","value":"PAC"}]},{"database":"InterPro","id":"IPR000014","properties":[{"key":"EntryName","value":"PAS"}]},{"database":"InterPro","id":"IPR000700","properties":[{"key":"EntryName","value":"PAS-assoc_C"}]},{"database":"InterPro","id":"IPR035965","properties":[{"key":"EntryName","value":"PAS-like_dom_sf"}]},{"database":"InterPro","id":"IPR000719","properties":[{"key":"EntryName","value":"Prot_kinase_dom"}]},{"database":"InterPro","id":"IPR017441","properties":[{"key":"EntryName","value":"Protein_kinase_ATP_BS"}]},{"database":"InterPro","id":"IPR008271","properties":[{"key":"EntryName","value":"Ser/Thr_kinase_AS"}]},{"database":"NCBIfam","id":"TIGR00229","properties":[{"key":"EntryName","value":"sensory_box"},{"key":"MatchStatus","value":"2"}]},{"database":"PANTHER","id":"PTHR45637","properties":[{"key":"EntryName","value":"FLIPPASE KINASE 1-RELATED"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF13426","properties":[{"key":"EntryName","value":"PAS_9"},{"key":"MatchStatus","value":"2"}]},{"database":"Pfam","id":"PF00069","properties":[{"key":"EntryName","value":"Pkinase"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00086","properties":[{"key":"EntryName","value":"PAC"},{"key":"MatchStatus","value":"2"}]},{"database":"SMART","id":"SM00091","properties":[{"key":"EntryName","value":"PAS"},{"key":"MatchStatus","value":"2"}]},{"database":"SMART","id":"SM00220","properties":[{"key":"EntryName","value":"S_TKc"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF56112","properties":[{"key":"EntryName","value":"Protein kinase-like (PK-like)"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF55785","properties":[{"key":"EntryName","value":"PYP-like sensor domain (PAS domain)"},{"key":"MatchStatus","value":"2"}]},{"database":"PROSITE","id":"PS50113","properties":[{"key":"EntryName","value":"PAC"},{"key":"MatchStatus","value":"2"}]},{"database":"PROSITE","id":"PS50112","properties":[{"key":"EntryName","value":"PAS"},{"key":"MatchStatus","value":"2"}]},{"database":"PROSITE","id":"PS00107","properties":[{"key":"EntryName","value":"PROTEIN_KINASE_ATP"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50011","properties":[{"key":"EntryName","value":"PROTEIN_KINASE_DOM"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00108","properties":[{"key":"EntryName","value":"PROTEIN_KINASE_ST"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MERSNAESSTTGELTNKWMAFDQGSNQNKPPIARVTPPEDDEYDITKIAERTAEWPGGATVAYAIGDEERNKRRSSSASWRSSRDNSLSSVEPRVSQDLKDALATLQQTFVVSDATKPDCPIMYASSGFFTMTGYSSKEVIGRNCRFLQGKETDQKEVDKIRHAVKTGTSYCGRLYNYKKDGTPFWNLLTVTPIKDENGNTIKFIGMQVEVSKYTEGVNEKELRPNGLPTSLIRYDARQKETALGSIVEVVQTVERPRNQYRSSLTEIQEKIVESPLVGPAENLSLYTPGRETPLSDIKGDLTRTSSWNSSHPKSRKSIRSSLMGFKGRSSVNEPTPPIIEPEELMTKDIARTDSWDRAERFRDIRQGIDLATTLERIEKNFVITDPRLPDNPIIFASDSFLELTEFTREEILGRNCRFLQGPETDQGTVDKIRAAIREQREITVQLINYTKSGKKFWNLFHLQPMRDQKGELQYFIGVQLDGSGHVEPLRNRLSDTTEKQSAKLVKATAENVDEAVRELPDANLRPEDLWAIHSQSVSPRPHKRYNTSWKAIQKITAGGEIIGLGHFKPIRPLGSGDTGSVHLVELKGTGELFAMKAMDKSVMLKRNKVHRACIEREIIALLDHPFLPTLYTSFQTPTHVCLITDFCPGGELFALLDKQPLKLFKEESARFYAAEVVIGLEYLHCLGIIYRDLKPENILLQTDGHVVLSDFDLSFRTQCKPQVIKHAPSKRRRSRSQPPPTFVAEPSTQSNSFVGTEEYIAPEVITGAGHSSAIDWWSVGILLYEMLYGRTPFRGKNRQKTFANILHKDLTFPSSIPVSLAARQMIHALLNRDPSARLGSNGGSSEIKEHAFFRGINWPLIRCMIPPPLDAPLELIEKDPNTKDVQWEDGALLENSLDIF","length":901,"molWeight":101499,"crc64":"12B7D8F0B0F76A05","md5":"52B1436B6415C990383FECEE01ED617C"},"extraAttributes":{"countByCommentType":{"CATALYTIC ACTIVITY":2,"COFACTOR":1,"SUBCELLULAR LOCATION":1,"SIMILARITY":2},"countByFeatureType":{"Domain":5,"Region":4,"Compositional bias":3,"Active site":1,"Binding site":1},"uniParcId":"UPI00078C1AAF"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0A8M0FGR5","uniProtkbId":"A0A8M0FGR5_ERICD","entryAudit":{"firstPublicDate":"2022-08-03","lastAnnotationUpdateDate":"2026-11-04","lastSequenceUpdateDate":"2022-08-03","entryVersion":16,"sequenceVersion":1},"annotationScore":3.0,"organism":{"scientificName":"Erigeron canadensis","commonName":"Canadian horseweed","synonyms":["Conyza canadensis"],"taxonId":72917,"evidences":[{"evidenceCode":"ECO:0000313","source":"PDB","id":"7E13"}],"lineage":["Eukaryota","Viridiplantae","Streptophyta","Embryophyta","Tracheophyta","Spermatophyta","Magnoliopsida","eudicotyledons","Gunneridae","Pentapetalae","asterids","campanulids","Asterales","Asteraceae","Asteroideae","Astereae","North American clade","Conyzinae","Erigeron"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000585"}],"value":"Serine hydroxymethyltransferase"},"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000585"}],"value":"2.1.2.1"}]}},"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00059150"}],"value":"Catalyzes the interconversion of serine and glycine"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000585"}],"value":"Interconversion of serine and glycine"}],"commentType":"FUNCTION"},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:15481"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:15636"},{"database":"ChEBI","id":"CHEBI:33384"},{"database":"ChEBI","id":"CHEBI:57305"},{"database":"ChEBI","id":"CHEBI:57453"}],"ecNumber":"2.1.2.1","evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00001528"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000585"}]}},{"commentType":"COFACTOR","cofactors":[{"name":"pyridoxal 5'-phosphate","evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00001933"},{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR000412-50"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000585"}],"cofactorCrossReference":{"database":"ChEBI","id":"CHEBI:597326"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004777"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000585"}],"value":"One-carbon metabolism; tetrahydrofolate interconversion"}],"commentType":"PATHWAY"},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004173"}],"value":"Mitochondrion","id":"SL-0173"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00006376"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000585"}],"value":"Belongs to the SHMT family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Domain","location":{"start":{"value":51,"modifier":"EXACT"},"end":{"value":447,"modifier":"EXACT"}},"description":"Serine hydroxymethyltransferase-like","evidences":[{"evidenceCode":"ECO:0000259","source":"Pfam","id":"PF00464"}]},{"type":"Binding site","location":{"start":{"value":98,"modifier":"EXACT"},"end":{"value":98,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:597326"}],"evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7E13"}],"ligand":{"name":"pyridoxal 5'-phosphate","id":"ChEBI:CHEBI:597326"}},{"type":"Binding site","location":{"start":{"value":144,"modifier":"EXACT"},"end":{"value":144,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:597326"}],"evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7E13"}],"ligand":{"name":"pyridoxal 5'-phosphate","id":"ChEBI:CHEBI:597326"}},{"type":"Binding site","location":{"start":{"value":145,"modifier":"EXACT"},"end":{"value":145,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:597326"}],"evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7E13"}],"ligand":{"name":"pyridoxal 5'-phosphate","id":"ChEBI:CHEBI:597326"}},{"type":"Binding site","location":{"start":{"value":146,"modifier":"EXACT"},"end":{"value":146,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:597326"}],"evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7E13"}],"ligand":{"name":"pyridoxal 5'-phosphate","id":"ChEBI:CHEBI:597326"}},{"type":"Binding site","location":{"start":{"value":173,"modifier":"EXACT"},"end":{"value":173,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:597326"}],"evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7E13"}],"ligand":{"name":"pyridoxal 5'-phosphate","id":"ChEBI:CHEBI:597326"}},{"type":"Binding site","location":{"start":{"value":228,"modifier":"EXACT"},"end":{"value":228,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:597326"}],"evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7E13"}],"ligand":{"name":"pyridoxal 5'-phosphate","id":"ChEBI:CHEBI:597326"}},{"type":"Binding site","location":{"start":{"value":281,"modifier":"EXACT"},"end":{"value":281,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:597326"}],"evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7E13"}],"ligand":{"name":"pyridoxal 5'-phosphate","id":"ChEBI:CHEBI:597326"}},{"type":"Binding site","location":{"start":{"value":282,"modifier":"EXACT"},"end":{"value":282,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:597326"}],"evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7E13"}],"ligand":{"name":"pyridoxal 5'-phosphate","id":"ChEBI:CHEBI:597326"}},{"type":"Binding site","location":{"start":{"value":327,"modifier":"EXACT"},"end":{"value":327,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:597326"}],"evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7E13"}],"ligand":{"name":"pyridoxal 5'-phosphate","id":"ChEBI:CHEBI:597326"}},{"type":"Modified residue","location":{"start":{"value":253,"modifier":"EXACT"},"end":{"value":253,"modifier":"EXACT"}},"description":"N6-(pyridoxal phosphate)lysine (covalent)","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7E13"}]},{"type":"Modified residue","location":{"start":{"value":282,"modifier":"EXACT"},"end":{"value":282,"modifier":"EXACT"}},"description":"N6-(pyridoxal phosphate)lysine","evidences":[{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR000412-50"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7E13"}],"id":"KW-0002","category":"Technical term","name":"3D-structure"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023128"}],"id":"KW-0496","category":"Cellular component","name":"Mitochondrion"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022563"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000585"}],"id":"KW-0554","category":"Biological process","name":"One-carbon metabolism"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022898"},{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR000412-50"}],"id":"KW-0663","category":"Ligand","name":"Pyridoxal phosphate"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022679"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000585"}],"id":"KW-0808","category":"Molecular function","name":"Transferase"}],"references":[{"referenceNumber":1,"citation":{"id":"CI-EO6KH10HLS50P","citationType":"submission","authors":["Li Z.R.","Bai L.Y."],"title":"serine hydroxymethyltransferase.","publicationDate":"JAN-2021","submissionDatabase":"PDB data bank"},"referencePositions":["X-RAY CRYSTALLOGRAPHY (2.86 ANGSTROMS) IN COMPLEX WITH PYRIDOXAL 5'-PHOSPHATE","PYRIDOXAL PHOSPHATE AT ASP-253"],"evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7E13"}]}],"uniProtKBCrossReferences":[{"database":"RefSeq","id":"XP_043640184.1","properties":[{"key":"NucleotideSequenceId","value":"XM_043784249.1"}]},{"database":"PDB","id":"7E13","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.86 A"},{"key":"Chains","value":"A/B/C/D=1-513"}]},{"database":"AlphaFoldDB","id":"A0A8M0FGR5","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"A0A8M0FGR5","properties":[{"key":"Description","value":"-"}]},{"database":"GeneID","id":"122611255","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"ecad:122611255","properties":[{"key":"Description","value":"-"}]},{"database":"OrthoDB","id":"10265628at2759","properties":[{"key":"Description","value":"-"}]},{"database":"UniPathway","id":"UPA00193","properties":[{"key":"RectionId","value":"-"}]},{"database":"GO","id":"GO:0005739","properties":[{"key":"GoTerm","value":"C:mitochondrion"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0004372","properties":[{"key":"GoTerm","value":"F:glycine hydroxymethyltransferase activity"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0030170","properties":[{"key":"GoTerm","value":"F:pyridoxal phosphate binding"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0006545","properties":[{"key":"GoTerm","value":"P:glycine biosynthetic process"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0035999","properties":[{"key":"GoTerm","value":"P:tetrahydrofolate interconversion"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniPathway"}]},{"database":"CDD","id":"cd00378","properties":[{"key":"EntryName","value":"SHMT"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.40.640.10:FF:000050","properties":[{"key":"EntryName","value":"Serine hydroxymethyltransferase"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.90.1150.10","properties":[{"key":"EntryName","value":"Aspartate Aminotransferase, domain 1"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.40.640.10","properties":[{"key":"EntryName","value":"Type I PLP-dependent aspartate aminotransferase-like (Major domain)"},{"key":"MatchStatus","value":"1"}]},{"database":"HAMAP","id":"MF_00051","properties":[{"key":"EntryName","value":"SHMT"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR015424","properties":[{"key":"EntryName","value":"PyrdxlP-dep_Trfase"}]},{"database":"InterPro","id":"IPR015421","properties":[{"key":"EntryName","value":"PyrdxlP-dep_Trfase_major"}]},{"database":"InterPro","id":"IPR015422","properties":[{"key":"EntryName","value":"PyrdxlP-dep_Trfase_small"}]},{"database":"InterPro","id":"IPR001085","properties":[{"key":"EntryName","value":"Ser_HO-MeTrfase"}]},{"database":"InterPro","id":"IPR049943","properties":[{"key":"EntryName","value":"Ser_HO-MeTrfase-like"}]},{"database":"InterPro","id":"IPR019798","properties":[{"key":"EntryName","value":"Ser_HO-MeTrfase_PLP_BS"}]},{"database":"InterPro","id":"IPR039429","properties":[{"key":"EntryName","value":"SHMT-like_dom"}]},{"database":"NCBIfam","id":"NF000586","properties":[{"key":"EntryName","value":"PRK00011.1"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR11680","properties":[{"key":"EntryName","value":"SERINE HYDROXYMETHYLTRANSFERASE"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR11680:SF44","properties":[{"key":"EntryName","value":"SERINE HYDROXYMETHYLTRANSFERASE"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00464","properties":[{"key":"EntryName","value":"SHMT"},{"key":"MatchStatus","value":"1"}]},{"database":"PIRSF","id":"PIRSF000412","properties":[{"key":"EntryName","value":"SHMT"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF53383","properties":[{"key":"EntryName","value":"PLP-dependent transferases"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00096","properties":[{"key":"EntryName","value":"SHMT"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MAMALALRRLSSSHRLSNRSSLKYLSSLPNPVARDIEDSRVKWTKQLNAPLEEIDPEIADIIELEKARQWKGFELIPSENFTSLSVMQAVGSVMTNKYSEGYPGARYYGGNEYIDMAERLCQKRALEAFNLDPSKWGVNVQSLSGSPANFQVYTALLKPHERIMALDLPHGGHLSHGYQTDTKKISAVSIFFETMPYRLDESTGYIDYEQMEKSAVLFRPKLIVAGASAYARVYDYARMRKVCDKQKAILLADMAHISGLVAAGVVPSPFEYADVVTTTTHKSLRGPRGAMIFFRKGLKEINKKGEEVMYDFEDKINQAVFPGLQGGPHNHTIAGLAVALKQATTPEYKAYQEQVLANCKRFSQSLIERGYSLVSGGTDNHLVLVNLRDKGIDGSRVEKVMELAHIAANKNTVPGDVSAMVPGGIRMGTPALTSRGFLEEDFVKVAELFDASVKLALKIKAASSGTKLKDFVATMNGDEKFQSEIKKIRGEVEEYAKQFPTIGFEKETMKYKN","length":513,"molWeight":56994,"crc64":"D3456748B12810C3","md5":"C79F0E16CE027E6A8A02BC1FDA6D4493"},"extraAttributes":{"countByCommentType":{"FUNCTION":2,"CATALYTIC ACTIVITY":1,"COFACTOR":1,"PATHWAY":1,"SUBCELLULAR LOCATION":1,"SIMILARITY":1},"countByFeatureType":{"Domain":1,"Binding site":9,"Modified residue":2},"uniParcId":"UPI001CB940C3"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"Q6A196","uniProtkbId":"Q6A196_ERICD","entryAudit":{"firstPublicDate":"2004-09-13","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2004-09-13","entryVersion":103,"sequenceVersion":1},"annotationScore":3.0,"organism":{"scientificName":"Erigeron canadensis","commonName":"Canadian horseweed","synonyms":["Conyza canadensis"],"taxonId":72917,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"CAH05075.1"}],"lineage":["Eukaryota","Viridiplantae","Streptophyta","Embryophyta","Tracheophyta","Spermatophyta","Magnoliopsida","eudicotyledons","Gunneridae","Pentapetalae","asterids","campanulids","Asterales","Asteraceae","Asteroideae","Astereae","North American clade","Conyzinae","Erigeron"]},"proteinExistence":"2: Evidence at transcript level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU361145"}],"value":"Ferritin"},"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU361145"}],"value":"1.16.3.1"}]}},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"CAH05075.1"}],"value":"fer"}}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00025111"}],"value":"Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase activity. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU361145"}],"value":"Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation"}],"commentType":"FUNCTION"},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"4 Fe(2+) + O2 + 4 H(+) = 4 Fe(3+) + 2 H2O","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:11148"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:15379"},{"database":"ChEBI","id":"CHEBI:29033"},{"database":"ChEBI","id":"CHEBI:29034"}],"ecNumber":"1.16.3.1","evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00047990"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU361145"}]}},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00026060"}],"value":"Oligomer of 24 subunits. There are two types of subunits: L (light) chain and H (heavy) chain. The major chain can be light or heavy, depending on the species and tissue type. The functional molecule forms a roughly spherical shell with a diameter of 12 nm and contains a central cavity into which the insoluble mineral iron core is deposited"}],"commentType":"SUBUNIT"},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004229"}],"value":"Plastid, chloroplast","id":"SL-0049"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00007513"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU361145"}],"value":"Belongs to the ferritin family"}],"commentType":"SIMILARITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00085"}],"value":"Lacks conserved residue(s) required for the propagation of feature annotation"}],"commentType":"CAUTION"}],"features":[{"type":"Domain","location":{"start":{"value":81,"modifier":"EXACT"},"end":{"value":234,"modifier":"EXACT"}},"description":"Ferritin-like diiron","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50905"}]},{"type":"Binding site","location":{"start":{"value":98,"modifier":"EXACT"},"end":{"value":98,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:24875"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR601519-1"}],"ligand":{"name":"Fe cation","id":"ChEBI:CHEBI:24875","label":"1"}},{"type":"Binding site","location":{"start":{"value":133,"modifier":"EXACT"},"end":{"value":133,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:24875"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR601519-1"}],"ligand":{"name":"Fe cation","id":"ChEBI:CHEBI:24875","label":"1"}},{"type":"Binding site","location":{"start":{"value":136,"modifier":"EXACT"},"end":{"value":136,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:24875"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR601519-1"}],"ligand":{"name":"Fe cation","id":"ChEBI:CHEBI:24875","label":"1"}},{"type":"Binding site","location":{"start":{"value":182,"modifier":"EXACT"},"end":{"value":182,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:24875"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR601519-1"}],"ligand":{"name":"Fe cation","id":"ChEBI:CHEBI:24875","label":"1"}},{"type":"Binding site","location":{"start":{"value":216,"modifier":"EXACT"},"end":{"value":216,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:24875"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR601519-1"}],"ligand":{"name":"Fe cation","id":"ChEBI:CHEBI:24875","label":"1"}}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022528"}],"id":"KW-0150","category":"Cellular component","name":"Chloroplast"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023004"},{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR601519-1"}],"id":"KW-0408","category":"Ligand","name":"Iron"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022434"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU361145"}],"id":"KW-0409","category":"Biological process","name":"Iron storage"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022723"},{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR601519-1"}],"id":"KW-0479","category":"Ligand","name":"Metal-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023002"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU361145"}],"id":"KW-0560","category":"Molecular function","name":"Oxidoreductase"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022640"}],"id":"KW-0934","category":"Cellular component","name":"Plastid"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022946"}],"id":"KW-0809","category":"Domain","name":"Transit peptide"}],"references":[{"referenceNumber":1,"citation":{"id":"16949961","citationType":"journal article","authors":["Soos V.","Jori B.","Paldi E.","Szego D.","Szigeti Z.","Racz I.","Lasztity D."],"citationCrossReferences":[{"database":"PubMed","id":"16949961"},{"database":"DOI","id":"10.1016/j.jplph.2005.08.015"}],"title":"Ferritin2 gene in paraquat-susceptible and resistant biotypes of horseweed Conyza canadensis (L.) Cronq.","publicationDate":"2006","journal":"J. Plant Physiol.","firstPage":"979","lastPage":"982","volume":"163"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"CAH05075.1"}],"value":"Leaf","type":"TISSUE"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"CAH05075.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AJ786262","properties":[{"key":"ProteinId","value":"CAH05075.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"AlphaFoldDB","id":"Q6A196","properties":[{"key":"Description","value":"-"}]},{"database":"GO","id":"GO:0009507","properties":[{"key":"GoTerm","value":"C:chloroplast"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0008199","properties":[{"key":"GoTerm","value":"F:ferric iron binding"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0008198","properties":[{"key":"GoTerm","value":"F:ferrous iron binding"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:0004322","properties":[{"key":"GoTerm","value":"F:ferroxidase activity"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-EC"}]},{"database":"GO","id":"GO:0006879","properties":[{"key":"GoTerm","value":"P:intracellular iron ion homeostasis"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0006826","properties":[{"key":"GoTerm","value":"P:iron ion transport"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0006979","properties":[{"key":"GoTerm","value":"P:response to oxidative stress"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"CDD","id":"cd01056","properties":[{"key":"EntryName","value":"Euk_Ferritin"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.1260.10:FF:000006","properties":[{"key":"EntryName","value":"Ferritin"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.20.1260.10","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR001519","properties":[{"key":"EntryName","value":"Ferritin"}]},{"database":"InterPro","id":"IPR012347","properties":[{"key":"EntryName","value":"Ferritin-like"}]},{"database":"InterPro","id":"IPR009040","properties":[{"key":"EntryName","value":"Ferritin-like_diiron"}]},{"database":"InterPro","id":"IPR009078","properties":[{"key":"EntryName","value":"Ferritin-like_SF"}]},{"database":"InterPro","id":"IPR014034","properties":[{"key":"EntryName","value":"Ferritin_CS"}]},{"database":"InterPro","id":"IPR008331","properties":[{"key":"EntryName","value":"Ferritin_DPS_dom"}]},{"database":"PANTHER","id":"PTHR11431","properties":[{"key":"EntryName","value":"FERRITIN"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR11431:SF128","properties":[{"key":"EntryName","value":"FERRITIN"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00210","properties":[{"key":"EntryName","value":"Ferritin"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF47240","properties":[{"key":"EntryName","value":"Ferritin-like"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00204","properties":[{"key":"EntryName","value":"FERRITIN_2"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50905","properties":[{"key":"EntryName","value":"FERRITIN_LIKE"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MLLKTAPASRLSSVPASVDNLTGSSRSIPSASHSPAIVCAAAKGGGSNNKPITGVVFEPFEEVKKELNLVPTVPQQSLARQKYADDSESIINEQINVEYNVSYVYHAMYAYFDRDNVALKGLAKFFKESSEEEREHAEKFMEYQNKRGGKVKLQSILMPLSEFDHAEKGDALYAMELALSLEKLTNEKLLHVHAVATKNNDVQLADFVESEFLGEQVEAIKRISEYVAQLRRVGKGHGVWHFDQMLLQEEGLVA","length":254,"molWeight":28260,"crc64":"DB5F83444CEBCAE1","md5":"97BFDB2BC3936849AC740CA7127D62E0"},"extraAttributes":{"countByCommentType":{"FUNCTION":2,"CATALYTIC ACTIVITY":1,"SUBUNIT":1,"SUBCELLULAR LOCATION":1,"SIMILARITY":1,"CAUTION":1},"countByFeatureType":{"Domain":1,"Binding site":5},"uniParcId":"UPI00003FF252"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0A126WWC9","uniProtkbId":"A0A126WWC9_ERICD","entryAudit":{"firstPublicDate":"2016-05-11","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2016-05-11","entryVersion":32,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Erigeron canadensis","commonName":"Canadian horseweed","synonyms":["Conyza canadensis"],"taxonId":72917,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AML76747.1"}],"lineage":["Eukaryota","Viridiplantae","Streptophyta","Embryophyta","Tracheophyta","Spermatophyta","Magnoliopsida","eudicotyledons","Gunneridae","Pentapetalae","asterids","campanulids","Asterales","Asteraceae","Asteroideae","Astereae","North American clade","Conyzinae","Erigeron"]},"proteinExistence":"2: Evidence at transcript level","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AML76747.1"}],"value":"Putative LOV domain-containing protein"}}]},"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004906"}],"value":"Protein modification; protein ubiquitination"}],"commentType":"PATHWAY"},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004123"}],"value":"Nucleus","id":"SL-0191"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00007833"}],"value":"Belongs to the ADAGIO family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Domain","location":{"start":{"value":73,"modifier":"EXACT"},"end":{"value":120,"modifier":"EXACT"}},"description":"PAS","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50112"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023108"}],"id":"KW-0090","category":"Biological process","name":"Biological rhythms"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022991"}],"id":"KW-0157","category":"Ligand","name":"Chromophore"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022630"}],"id":"KW-0285","category":"Ligand","name":"Flavoprotein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023089"}],"id":"KW-0287","category":"Biological process","name":"Flowering"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022643"}],"id":"KW-0288","category":"Ligand","name":"FMN"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022441"}],"id":"KW-0880","category":"Domain","name":"Kelch repeat"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023242"}],"id":"KW-0539","category":"Cellular component","name":"Nucleus"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022543"}],"id":"KW-0600","category":"Molecular function","name":"Photoreceptor protein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023170"}],"id":"KW-0675","category":"Molecular function","name":"Receptor"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022737"}],"id":"KW-0677","category":"Domain","name":"Repeat"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022606"}],"id":"KW-0716","category":"Biological process","name":"Sensory transduction"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022786"}],"id":"KW-0833","category":"Biological process","name":"Ubl conjugation pathway"}],"references":[{"referenceNumber":1,"citation":{"id":"26929367","citationType":"journal article","authors":["Glantz S.T.","Carpenter E.J.","Melkonian M.","Gardner K.H.","Boyden E.S.","Wong G.K.","Chow B.Y."],"citationCrossReferences":[{"database":"PubMed","id":"26929367"},{"database":"DOI","id":"10.1073/pnas.1509428113"}],"title":"Functional and topological diversity of LOV domain photoreceptors.","publicationDate":"2016","journal":"Proc. Natl. Acad. Sci. U.S.A.","firstPage":"E1442","lastPage":"E1451","volume":"113"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AML76747.1"}],"value":"DESP_2107638","type":"STRAIN"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AML76747.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"KU698636","properties":[{"key":"ProteinId","value":"AML76747.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"AlphaFoldDB","id":"A0A126WWC9","properties":[{"key":"Description","value":"-"}]},{"database":"UniPathway","id":"UPA00143","properties":[{"key":"RectionId","value":"-"}]},{"database":"GO","id":"GO:0005829","properties":[{"key":"GoTerm","value":"C:cytosol"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:0005634","properties":[{"key":"GoTerm","value":"C:nucleus"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0019005","properties":[{"key":"GoTerm","value":"C:SCF ubiquitin ligase complex"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:0007623","properties":[{"key":"GoTerm","value":"P:circadian rhythm"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0016567","properties":[{"key":"GoTerm","value":"P:protein ubiquitination"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniPathway"}]},{"database":"GO","id":"GO:0009637","properties":[{"key":"GoTerm","value":"P:response to blue light"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:0006511","properties":[{"key":"GoTerm","value":"P:ubiquitin-dependent protein catabolic process"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"CDD","id":"cd22154","properties":[{"key":"EntryName","value":"F-box_AtADO-like"},{"key":"MatchStatus","value":"1"}]},{"database":"CDD","id":"cd00130","properties":[{"key":"EntryName","value":"PAS"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.30.450.20:FF:000041","properties":[{"key":"EntryName","value":"Adagio protein 1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.120.10.80:FF:000005","properties":[{"key":"EntryName","value":"Putative LOV domain-containing protein"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.120.10.80:FF:000026","properties":[{"key":"EntryName","value":"Putative LOV domain-containing protein"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.120.10.80","properties":[{"key":"EntryName","value":"Kelch-type beta propeller"},{"key":"MatchStatus","value":"2"}]},{"database":"Gene3D","id":"3.30.450.20","properties":[{"key":"EntryName","value":"PAS domain"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR036047","properties":[{"key":"EntryName","value":"F-box-like_dom_sf"}]},{"database":"InterPro","id":"IPR001810","properties":[{"key":"EntryName","value":"F-box_dom"}]},{"database":"InterPro","id":"IPR011043","properties":[{"key":"EntryName","value":"Gal_Oxase/kelch_b-propeller"}]},{"database":"InterPro","id":"IPR015915","properties":[{"key":"EntryName","value":"Kelch-typ_b-propeller"}]},{"database":"InterPro","id":"IPR011498","properties":[{"key":"EntryName","value":"Kelch_2"}]},{"database":"InterPro","id":"IPR001610","properties":[{"key":"EntryName","value":"PAC"}]},{"database":"InterPro","id":"IPR000014","properties":[{"key":"EntryName","value":"PAS"}]},{"database":"InterPro","id":"IPR035965","properties":[{"key":"EntryName","value":"PAS-like_dom_sf"}]},{"database":"NCBIfam","id":"TIGR00229","properties":[{"key":"EntryName","value":"sensory_box"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR46175:SF2","properties":[{"key":"EntryName","value":"ADAGIO PROTEIN 3"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR46175","properties":[{"key":"EntryName","value":"BACTERIOOPSIN TRANSCRIPTIONAL ACTIVATOR"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00646","properties":[{"key":"EntryName","value":"F-box"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF07646","properties":[{"key":"EntryName","value":"Kelch_2"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF24681","properties":[{"key":"EntryName","value":"Kelch_KLHDC2_KLHL20_DRC7"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF13426","properties":[{"key":"EntryName","value":"PAS_9"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00086","properties":[{"key":"EntryName","value":"PAC"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF81383","properties":[{"key":"EntryName","value":"F-box domain"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF50965","properties":[{"key":"EntryName","value":"Galactose oxidase, central domain"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF55785","properties":[{"key":"EntryName","value":"PYP-like sensor domain (PAS domain)"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50112","properties":[{"key":"EntryName","value":"PAS"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MGILAKEENDDVSADDVHLTKKLKYTAAQDDEQKQLQLLEEEDYSCSDEEEEIDDDNNDGFGLRLGEFFNPMIPTSIVVSDAMEPDLPIIYVNKVFESVTGYRADEVLGRNCRFLQYRDPRAQRRHPLVDPVCVSEIRRCLNEGLDFQGELLNFRKDGTPMVNRLRLAPIHDDDGIVTHVIGIQVFTETKIDLNSVSYPVFKETCKNQSDQEVGKYSPKSGQIKYIECQEICGILQLSDEVMAHNILSRLTPRDVASIGSVCTRIRQLTKNEHLRKMVCQNAWGREVTGALENMTHKLGWGRLARELTTLEAVCWKKLRVGGAVEPSRCNFSACAAGNRLVLFGGEGVNMQPMDDTFVLNLDAVNPEWRQVSVKSSPPGRWGHTLSCLNGSWLVIFGGCGKQGLLNDVFVLDLDAKQPTWIEVYGGGAPPPRSWHSSCTIEGSKLVVSGGCTDAGVLLNDTFLLDLTMKNPIWREIPTSQVPPSRLGHSLSVYGRTKILMFGGLANSGHLRLRSSEVYTIDLMDEKPQWRLLECNAFTGVGTQSAVVPPPRLDHVAMSMPCGRIIIFGGSIAGLHSPAQVFLLDPAEEKPSWRILNVPGQPPKFAWGHSTCVVGGTRVLVLGGHTGEEWVLNELHELCLASRQDVES","length":647,"molWeight":71736,"crc64":"FF90BF6CEB17707B","md5":"7EC8017C6C76E644D5CE1F7B998B403B"},"extraAttributes":{"countByCommentType":{"PATHWAY":1,"SUBCELLULAR LOCATION":1,"SIMILARITY":1},"countByFeatureType":{"Domain":1},"uniParcId":"UPI00078EA21A"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0A126WZL4","uniProtkbId":"A0A126WZL4_ERICD","entryAudit":{"firstPublicDate":"2016-05-11","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2016-05-11","entryVersion":28,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Erigeron canadensis","commonName":"Canadian horseweed","synonyms":["Conyza canadensis"],"taxonId":72917,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AML77861.1"}],"lineage":["Eukaryota","Viridiplantae","Streptophyta","Embryophyta","Tracheophyta","Spermatophyta","Magnoliopsida","eudicotyledons","Gunneridae","Pentapetalae","asterids","campanulids","Asterales","Asteraceae","Asteroideae","Astereae","North American clade","Conyzinae","Erigeron"]},"proteinExistence":"2: Evidence at transcript level","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AML77861.1"}],"value":"Putative LOV domain-containing protein"}}]},"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004906"}],"value":"Protein modification; protein ubiquitination"}],"commentType":"PATHWAY"},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004123"}],"value":"Nucleus","id":"SL-0191"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00007833"}],"value":"Belongs to the ADAGIO family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Domain","location":{"start":{"value":31,"modifier":"EXACT"},"end":{"value":106,"modifier":"EXACT"}},"description":"PAS","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50112"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023108"}],"id":"KW-0090","category":"Biological process","name":"Biological rhythms"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022991"}],"id":"KW-0157","category":"Ligand","name":"Chromophore"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022630"}],"id":"KW-0285","category":"Ligand","name":"Flavoprotein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023089"}],"id":"KW-0287","category":"Biological process","name":"Flowering"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022643"}],"id":"KW-0288","category":"Ligand","name":"FMN"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022441"}],"id":"KW-0880","category":"Domain","name":"Kelch repeat"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023242"}],"id":"KW-0539","category":"Cellular component","name":"Nucleus"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022543"}],"id":"KW-0600","category":"Molecular function","name":"Photoreceptor protein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023170"}],"id":"KW-0675","category":"Molecular function","name":"Receptor"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022737"}],"id":"KW-0677","category":"Domain","name":"Repeat"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022606"}],"id":"KW-0716","category":"Biological process","name":"Sensory transduction"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022786"}],"id":"KW-0833","category":"Biological process","name":"Ubl conjugation pathway"}],"references":[{"referenceNumber":1,"citation":{"id":"26929367","citationType":"journal article","authors":["Glantz S.T.","Carpenter E.J.","Melkonian M.","Gardner K.H.","Boyden E.S.","Wong G.K.","Chow B.Y."],"citationCrossReferences":[{"database":"PubMed","id":"26929367"},{"database":"DOI","id":"10.1073/pnas.1509428113"}],"title":"Functional and topological diversity of LOV domain photoreceptors.","publicationDate":"2016","journal":"Proc. Natl. Acad. Sci. U.S.A.","firstPage":"E1442","lastPage":"E1451","volume":"113"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AML77861.1"}],"value":"MHYG_2087147","type":"STRAIN"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AML78045.1"}],"value":"NUSE_2067233","type":"STRAIN"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AML77861.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"KU699996","properties":[{"key":"ProteinId","value":"AML77861.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"KU700219","properties":[{"key":"ProteinId","value":"AML78045.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"AlphaFoldDB","id":"A0A126WZL4","properties":[{"key":"Description","value":"-"}]},{"database":"UniPathway","id":"UPA00143","properties":[{"key":"RectionId","value":"-"}]},{"database":"GO","id":"GO:0005829","properties":[{"key":"GoTerm","value":"C:cytosol"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:0005634","properties":[{"key":"GoTerm","value":"C:nucleus"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0019005","properties":[{"key":"GoTerm","value":"C:SCF ubiquitin ligase complex"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:0007623","properties":[{"key":"GoTerm","value":"P:circadian rhythm"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0016567","properties":[{"key":"GoTerm","value":"P:protein ubiquitination"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniPathway"}]},{"database":"GO","id":"GO:0009637","properties":[{"key":"GoTerm","value":"P:response to blue light"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:0006511","properties":[{"key":"GoTerm","value":"P:ubiquitin-dependent protein catabolic process"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"CDD","id":"cd22154","properties":[{"key":"EntryName","value":"F-box_AtADO-like"},{"key":"MatchStatus","value":"1"}]},{"database":"CDD","id":"cd00130","properties":[{"key":"EntryName","value":"PAS"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.30.450.20:FF:000041","properties":[{"key":"EntryName","value":"Adagio protein 1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.120.10.80:FF:000005","properties":[{"key":"EntryName","value":"Putative LOV domain-containing protein"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.120.10.80:FF:000062","properties":[{"key":"EntryName","value":"Putative LOV domain-containing protein"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.20.1280.50","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.120.10.80","properties":[{"key":"EntryName","value":"Kelch-type beta propeller"},{"key":"MatchStatus","value":"3"}]},{"database":"Gene3D","id":"3.30.450.20","properties":[{"key":"EntryName","value":"PAS domain"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR036047","properties":[{"key":"EntryName","value":"F-box-like_dom_sf"}]},{"database":"InterPro","id":"IPR001810","properties":[{"key":"EntryName","value":"F-box_dom"}]},{"database":"InterPro","id":"IPR015915","properties":[{"key":"EntryName","value":"Kelch-typ_b-propeller"}]},{"database":"InterPro","id":"IPR011498","properties":[{"key":"EntryName","value":"Kelch_2"}]},{"database":"InterPro","id":"IPR000014","properties":[{"key":"EntryName","value":"PAS"}]},{"database":"InterPro","id":"IPR035965","properties":[{"key":"EntryName","value":"PAS-like_dom_sf"}]},{"database":"PANTHER","id":"PTHR46175:SF5","properties":[{"key":"EntryName","value":"ADAGIO PROTEIN 1"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR46175","properties":[{"key":"EntryName","value":"BACTERIOOPSIN TRANSCRIPTIONAL ACTIVATOR"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF12937","properties":[{"key":"EntryName","value":"F-box-like"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF07646","properties":[{"key":"EntryName","value":"Kelch_2"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF24681","properties":[{"key":"EntryName","value":"Kelch_KLHDC2_KLHL20_DRC7"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF13426","properties":[{"key":"EntryName","value":"PAS_9"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF81383","properties":[{"key":"EntryName","value":"F-box domain"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF117281","properties":[{"key":"EntryName","value":"Kelch motif"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF55785","properties":[{"key":"EntryName","value":"PYP-like sensor domain (PAS domain)"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50112","properties":[{"key":"EntryName","value":"PAS"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MEWDSNSDISGDEEGFLLNDGSGLPFPVDTLLQPAPCGFVVTDALEPDHPIIYVNSVFEIITGYRAEEVLGRNCRFLQCRGPYAKRRHPLVDSTVVSEIRRCIESGIEFKGELLNFTKDGTPLMNRLRMTPIYGDDDVITHIIGIQFFTEVDLDLGPLPGSTIKGIVKVSDRFQSSLLSCRLTPAETRNSSSGLCGLLQLSDEVISLKILSLLTPRDIASVGSVCRRFYEVAKNEDLWRMVCQNAWGSETTRVLETVPGAKRLGWGRLARELTTLEAAAWRKVTVGGAVEPSRCNFSACAVGNRVVLFGGEGVNMQPLNDTFVLDLNSTKPKWEHVKVGSPPPGRWGHTLSCVNDSNLVVFGGCGTQGLLNDVFLLDLDAKHPTWREISGLAPPLPRSWHSSCTLDGTKLIVSGGCADSGVLLSDTFLLDLSMEKPIWREIPVTWTPPSRLGHTLTVYGGRKILMFGGLAKSGPLRFRSSDVFTMDLSEDEPCWRSVTGSGMPGAGNPGGIGPPPRLDHVAVSLPGGRILVFGGSVAGLHSASQLYILDPTEEKPTWRILNVPGRPPRFAWGHSTCVVGGTRAIVLGGQTGEEWMLSELHELSLASSV","length":608,"molWeight":66029,"crc64":"21141F06B96821F9","md5":"9368608BD9D4442784B32B327CE66ED8"},"extraAttributes":{"countByCommentType":{"PATHWAY":1,"SUBCELLULAR LOCATION":1,"SIMILARITY":1},"countByFeatureType":{"Domain":1},"uniParcId":"UPI00078E7070"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0A2Z4LI68","uniProtkbId":"A0A2Z4LI68_ERICD","entryAudit":{"firstPublicDate":"2018-10-10","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2018-10-10","entryVersion":27,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Erigeron canadensis","commonName":"Canadian horseweed","synonyms":["Conyza canadensis"],"taxonId":72917,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AWX36190.1"}],"lineage":["Eukaryota","Viridiplantae","Streptophyta","Embryophyta","Tracheophyta","Spermatophyta","Magnoliopsida","eudicotyledons","Gunneridae","Pentapetalae","asterids","campanulids","Asterales","Asteraceae","Asteroideae","Astereae","North American clade","Conyzinae","Erigeron"]},"proteinExistence":"2: Evidence at transcript level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU363080"}],"value":"Chlorophyll a-b binding protein, chloroplastic"}}},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AWX36190.1"}],"value":"Lhcz6"}}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00003803"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU363080"}],"value":"The light-harvesting complex (LHC) functions as a light receptor, it captures and delivers excitation energy to photosystems with which it is closely associated"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00011769"}],"value":"The LHC complex consists of chlorophyll a-b binding proteins"}],"commentType":"SUBUNIT"},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004454"}],"value":"Plastid, chloroplast thylakoid membrane","id":"SL-0058"},"topology":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004454"}],"value":"Multi-pass membrane protein","id":"SL-9909"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00007259"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU363080"}],"value":"Belongs to the light-harvesting chlorophyll a/b-binding (LHC) protein family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Region","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":20,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":13,"modifier":"EXACT"}},"description":"Polar residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Binding site","location":{"start":{"value":58,"modifier":"EXACT"},"end":{"value":58,"modifier":"EXACT"}},"description":"axial binding residue","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:61721"},{"database":"ChEBI","id":"CHEBI:25107"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR601344-1"}],"ligand":{"name":"chlorophyll b","id":"ChEBI:CHEBI:61721","label":"1"},"ligandPart":{"name":"Mg","id":"ChEBI:CHEBI:25107"}},{"type":"Binding site","location":{"start":{"value":80,"modifier":"EXACT"},"end":{"value":80,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:58416"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR601344-1"}],"ligand":{"name":"chlorophyll a","id":"ChEBI:CHEBI:58416","label":"1"}},{"type":"Binding site","location":{"start":{"value":86,"modifier":"EXACT"},"end":{"value":86,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:58416"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR601344-1"}],"ligand":{"name":"chlorophyll a","id":"ChEBI:CHEBI:58416","label":"1"}},{"type":"Binding site","location":{"start":{"value":99,"modifier":"EXACT"},"end":{"value":99,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:58416"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR601344-1"}],"ligand":{"name":"chlorophyll a","id":"ChEBI:CHEBI:58416","label":"1"}},{"type":"Binding site","location":{"start":{"value":102,"modifier":"EXACT"},"end":{"value":102,"modifier":"EXACT"}},"description":"axial binding residue","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:58416"},{"database":"ChEBI","id":"CHEBI:25107"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR601344-1"}],"ligand":{"name":"chlorophyll a","id":"ChEBI:CHEBI:58416","label":"1"},"ligandPart":{"name":"Mg","id":"ChEBI:CHEBI:25107"}},{"type":"Binding site","location":{"start":{"value":104,"modifier":"EXACT"},"end":{"value":104,"modifier":"EXACT"}},"description":"axial binding residue","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:61721"},{"database":"ChEBI","id":"CHEBI:25107"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR601344-1"}],"ligand":{"name":"chlorophyll b","id":"ChEBI:CHEBI:61721","label":"1"},"ligandPart":{"name":"Mg","id":"ChEBI:CHEBI:25107"}},{"type":"Binding site","location":{"start":{"value":137,"modifier":"EXACT"},"end":{"value":137,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:58416"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR601344-1"}],"ligand":{"name":"chlorophyll a","id":"ChEBI:CHEBI:58416","label":"1"}},{"type":"Binding site","location":{"start":{"value":147,"modifier":"EXACT"},"end":{"value":147,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:58416"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR601344-1"}],"ligand":{"name":"chlorophyll a","id":"ChEBI:CHEBI:58416","label":"1"}},{"type":"Binding site","location":{"start":{"value":153,"modifier":"EXACT"},"end":{"value":153,"modifier":"EXACT"}},"description":"axial binding residue","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:61721"},{"database":"ChEBI","id":"CHEBI:25107"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR601344-1"}],"ligand":{"name":"chlorophyll b","id":"ChEBI:CHEBI:61721","label":"1"},"ligandPart":{"name":"Mg","id":"ChEBI:CHEBI:25107"}},{"type":"Binding site","location":{"start":{"value":157,"modifier":"EXACT"},"end":{"value":157,"modifier":"EXACT"}},"description":"axial binding residue","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:61721"},{"database":"ChEBI","id":"CHEBI:25107"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR601344-1"}],"ligand":{"name":"chlorophyll b","id":"ChEBI:CHEBI:61721","label":"1"},"ligandPart":{"name":"Mg","id":"ChEBI:CHEBI:25107"}},{"type":"Binding site","location":{"start":{"value":165,"modifier":"EXACT"},"end":{"value":165,"modifier":"EXACT"}},"description":"axial binding residue","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:61721"},{"database":"ChEBI","id":"CHEBI:25107"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR601344-1"}],"ligand":{"name":"chlorophyll b","id":"ChEBI:CHEBI:61721","label":"1"},"ligandPart":{"name":"Mg","id":"ChEBI:CHEBI:25107"}},{"type":"Binding site","location":{"start":{"value":173,"modifier":"EXACT"},"end":{"value":173,"modifier":"EXACT"}},"description":"axial binding residue","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:61721"},{"database":"ChEBI","id":"CHEBI:25107"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR601344-1"}],"ligand":{"name":"chlorophyll b","id":"ChEBI:CHEBI:61721","label":"1"},"ligandPart":{"name":"Mg","id":"ChEBI:CHEBI:25107"}},{"type":"Binding site","location":{"start":{"value":182,"modifier":"EXACT"},"end":{"value":182,"modifier":"EXACT"}},"description":"axial binding residue","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:61721"},{"database":"ChEBI","id":"CHEBI:25107"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR601344-1"}],"ligand":{"name":"chlorophyll b","id":"ChEBI:CHEBI:61721","label":"1"},"ligandPart":{"name":"Mg","id":"ChEBI:CHEBI:25107"}},{"type":"Binding site","location":{"start":{"value":213,"modifier":"EXACT"},"end":{"value":213,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:58416"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR601344-1"}],"ligand":{"name":"chlorophyll a","id":"ChEBI:CHEBI:58416","label":"1"}},{"type":"Binding site","location":{"start":{"value":214,"modifier":"EXACT"},"end":{"value":214,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:58416"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR601344-1"}],"ligand":{"name":"chlorophyll a","id":"ChEBI:CHEBI:58416","label":"1"}},{"type":"Binding site","location":{"start":{"value":217,"modifier":"EXACT"},"end":{"value":217,"modifier":"EXACT"}},"description":"axial binding residue","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:58416"},{"database":"ChEBI","id":"CHEBI:25107"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR601344-1"}],"ligand":{"name":"chlorophyll a","id":"ChEBI:CHEBI:58416","label":"3"},"ligandPart":{"name":"Mg","id":"ChEBI:CHEBI:25107"}},{"type":"Binding site","location":{"start":{"value":219,"modifier":"EXACT"},"end":{"value":219,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:58416"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR601344-1"}],"ligand":{"name":"chlorophyll a","id":"ChEBI:CHEBI:58416","label":"1"}},{"type":"Binding site","location":{"start":{"value":231,"modifier":"EXACT"},"end":{"value":231,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:58416"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR601344-1"}],"ligand":{"name":"chlorophyll a","id":"ChEBI:CHEBI:58416","label":"1"}},{"type":"Binding site","location":{"start":{"value":246,"modifier":"EXACT"},"end":{"value":246,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:58416"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR601344-1"}],"ligand":{"name":"chlorophyll a","id":"ChEBI:CHEBI:58416","label":"1"}},{"type":"Binding site","location":{"start":{"value":255,"modifier":"EXACT"},"end":{"value":255,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:58416"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR601344-1"}],"ligand":{"name":"chlorophyll a","id":"ChEBI:CHEBI:58416","label":"1"}},{"type":"Binding site","location":{"start":{"value":262,"modifier":"EXACT"},"end":{"value":262,"modifier":"EXACT"}},"description":"axial binding residue","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:61721"},{"database":"ChEBI","id":"CHEBI:25107"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR601344-1"}],"ligand":{"name":"chlorophyll b","id":"ChEBI:CHEBI:61721","label":"1"},"ligandPart":{"name":"Mg","id":"ChEBI:CHEBI:25107"}}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022494"},{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR601344-1"}],"id":"KW-0148","category":"Ligand","name":"Chlorophyll"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022528"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU363080"}],"id":"KW-0150","category":"Cellular component","name":"Chloroplast"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022991"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU363080"}],"id":"KW-0157","category":"Ligand","name":"Chromophore"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022842"}],"id":"KW-0460","category":"Ligand","name":"Magnesium"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023136"}],"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022723"}],"id":"KW-0479","category":"Ligand","name":"Metal-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022553"}],"id":"KW-0597","category":"PTM","name":"Phosphoprotein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022531"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU363080"}],"id":"KW-0602","category":"Biological process","name":"Photosynthesis"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022836"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU363080"}],"id":"KW-0603","category":"Cellular component","name":"Photosystem I"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023276"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU363080"}],"id":"KW-0604","category":"Cellular component","name":"Photosystem II"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022640"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU363080"}],"id":"KW-0934","category":"Cellular component","name":"Plastid"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023078"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU363080"}],"id":"KW-0793","category":"Cellular component","name":"Thylakoid"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022692"}],"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022989"}],"id":"KW-1133","category":"Domain","name":"Transmembrane helix"}],"references":[{"referenceNumber":1,"citation":{"id":"CI-A8BJQFFGFBCVK","citationType":"submission","authors":["Li Z.","Yuan P.","Bai L."],"title":"Cloning analysis of light harvesting protein LHCII-Z6 gene in Conyza canadensis and its response to caprylic acid stress.","publicationDate":"JUN-2018","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AWX36190.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"MH512007","properties":[{"key":"ProteinId","value":"AWX36190.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"AlphaFoldDB","id":"A0A2Z4LI68","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"A0A2Z4LI68","properties":[{"key":"Description","value":"-"}]},{"database":"OrthoDB","id":"423598at2759","properties":[{"key":"Description","value":"-"}]},{"database":"GO","id":"GO:0009535","properties":[{"key":"GoTerm","value":"C:chloroplast thylakoid membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0009765","properties":[{"key":"GoTerm","value":"P:photosynthesis, light harvesting"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"FunFam","id":"1.10.3460.10:FF:000001","properties":[{"key":"EntryName","value":"Chlorophyll a-b binding protein, chloroplastic"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.10.3460.10","properties":[{"key":"EntryName","value":"Chlorophyll a/b binding protein domain"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR001344","properties":[{"key":"EntryName","value":"Chloro_AB-bd_pln"}]},{"database":"InterPro","id":"IPR022796","properties":[{"key":"EntryName","value":"Chloroa_b-bind"}]},{"database":"PANTHER","id":"PTHR21649","properties":[{"key":"EntryName","value":"CHLOROPHYLL A/B BINDING PROTEIN"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00504","properties":[{"key":"EntryName","value":"Chloroa_b-bind"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF103511","properties":[{"key":"EntryName","value":"Chlorophyll a-b binding protein"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MAASTMALSSPFTGQAVKATPSGSELFGNGRVSMRKTAAAKKVAPSGSPWYGPDRVKYLGPFSGEAPSYLTGEFPGDYGWDTAGLSADPETFAKNRELEVIHSRWAMLGALGCVFPELLARNGVKFGEAVWFKAGAQIFSEGGLDYLGNPSLVHAQSILAIWATQVILMGAVEGYRIAGGPLGEVVDPLYPGGSFDPLGLADDPEAFAELKVKELKNGRLAMFSMFGFFVQAIVTGKGPLENLADHLADPVANNAWSYATNFVPGK","length":266,"molWeight":28143,"crc64":"E89D0E8DC779E8E0","md5":"DA372952CADD927C37AF003BA42D9E94"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"SUBUNIT":1,"SUBCELLULAR LOCATION":1,"SIMILARITY":1},"countByFeatureType":{"Region":1,"Compositional bias":1,"Binding site":21},"uniParcId":"UPI000DC7DA65"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"G4U4J4","uniProtkbId":"G4U4J4_ERICD","entryAudit":{"firstPublicDate":"2011-12-14","lastAnnotationUpdateDate":"2026-11-04","lastSequenceUpdateDate":"2011-12-14","entryVersion":49,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Erigeron canadensis","commonName":"Canadian horseweed","synonyms":["Conyza canadensis"],"taxonId":72917,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"CCB84814.1"}],"lineage":["Eukaryota","Viridiplantae","Streptophyta","Embryophyta","Tracheophyta","Spermatophyta","Magnoliopsida","eudicotyledons","Gunneridae","Pentapetalae","asterids","campanulids","Asterales","Asteraceae","Asteroideae","Astereae","North American clade","Conyzinae","Erigeron"]},"proteinExistence":"2: Evidence at transcript level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00012450"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU004164"}],"value":"3-phosphoshikimate 1-carboxyvinyltransferase"},"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00012450"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU004164"}],"value":"2.5.1.19"}]}},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"CCB84814.1"}],"value":"EPSPS-1"}}],"comments":[{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"3-phosphoshikimate + phosphoenolpyruvate = 5-O-(1-carboxyvinyl)-3-phosphoshikimate + phosphate","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:21256"},{"database":"ChEBI","id":"CHEBI:43474"},{"database":"ChEBI","id":"CHEBI:57701"},{"database":"ChEBI","id":"CHEBI:58702"},{"database":"ChEBI","id":"CHEBI:145989"}],"ecNumber":"2.5.1.19","evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00044633"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:21257"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00044633"}]}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004811"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU004164"}],"value":"Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 6/7"}],"commentType":"PATHWAY"},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004229"}],"value":"Plastid, chloroplast","id":"SL-0049"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00009948"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU004164"}],"value":"Belongs to the EPSP synthase family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Domain","location":{"start":{"value":83,"modifier":"EXACT"},"end":{"value":513,"modifier":"EXACT"}},"description":"Enolpyruvate transferase","evidences":[{"evidenceCode":"ECO:0000259","source":"Pfam","id":"PF00275"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022605"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU004164"}],"id":"KW-0028","category":"Biological process","name":"Amino-acid biosynthesis"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023141"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU004164"}],"id":"KW-0057","category":"Biological process","name":"Aromatic amino acid biosynthesis"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022528"}],"id":"KW-0150","category":"Cellular component","name":"Chloroplast"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022640"}],"id":"KW-0934","category":"Cellular component","name":"Plastid"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022679"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU004164"}],"id":"KW-0808","category":"Molecular function","name":"Transferase"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022946"}],"id":"KW-0809","category":"Domain","name":"Transit peptide"}],"references":[{"referenceNumber":1,"citation":{"id":"CI-3URMRHU5QF8MI","citationType":"submission","authors":["Nol N.","Livieratos I.","Giannopolitis C."],"title":"Reduced susceptibility to glyphosate of Conyza canadensis plants from a conventional citrus orchard in Crete (Greece) and early detection of resistance with the shikimate leaf disc assay.","publicationDate":"JUN-2011","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"CCB84814.1"}],"value":"B biotype","type":"STRAIN"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"CCB84814.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"FR872820","properties":[{"key":"ProteinId","value":"CCB84814.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"AlphaFoldDB","id":"G4U4J4","properties":[{"key":"Description","value":"-"}]},{"database":"UniPathway","id":"UPA00053","properties":[{"key":"RectionId","value":"UER00089"}]},{"database":"GO","id":"GO:0009507","properties":[{"key":"GoTerm","value":"C:chloroplast"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0003866","properties":[{"key":"GoTerm","value":"F:3-phosphoshikimate 1-carboxyvinyltransferase activity"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniRule"}]},{"database":"GO","id":"GO:0009073","properties":[{"key":"GoTerm","value":"P:aromatic amino acid biosynthetic process"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniRule"}]},{"database":"GO","id":"GO:0009423","properties":[{"key":"GoTerm","value":"P:chorismate biosynthetic process"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniRule"}]},{"database":"CDD","id":"cd01556","properties":[{"key":"EntryName","value":"EPSP_synthase"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.65.10.10:FF:000004","properties":[{"key":"EntryName","value":"3-phosphoshikimate 1-carboxyvinyltransferase"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.65.10.10:FF:000009","properties":[{"key":"EntryName","value":"3-phosphoshikimate 1-carboxyvinyltransferase"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.65.10.10","properties":[{"key":"EntryName","value":"Enolpyruvate transferase domain"},{"key":"MatchStatus","value":"2"}]},{"database":"HAMAP","id":"MF_00210","properties":[{"key":"EntryName","value":"EPSP_synth"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR001986","properties":[{"key":"EntryName","value":"Enolpyruvate_Tfrase_dom"}]},{"database":"InterPro","id":"IPR036968","properties":[{"key":"EntryName","value":"Enolpyruvate_Tfrase_sf"}]},{"database":"InterPro","id":"IPR006264","properties":[{"key":"EntryName","value":"EPSP_synthase"}]},{"database":"InterPro","id":"IPR023193","properties":[{"key":"EntryName","value":"EPSP_synthase_CS"}]},{"database":"InterPro","id":"IPR013792","properties":[{"key":"EntryName","value":"RNA3'P_cycl/enolpyr_Trfase_a/b"}]},{"database":"NCBIfam","id":"TIGR01356","properties":[{"key":"EntryName","value":"aroA"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR21090","properties":[{"key":"EntryName","value":"AROM/DEHYDROQUINATE SYNTHASE"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR21090:SF5","properties":[{"key":"EntryName","value":"PENTAFUNCTIONAL AROM POLYPEPTIDE"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00275","properties":[{"key":"EntryName","value":"EPSP_synthase"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF55205","properties":[{"key":"EntryName","value":"EPT/RTPC-like"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00104","properties":[{"key":"EntryName","value":"EPSP_SYNTHASE_1"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00885","properties":[{"key":"EntryName","value":"EPSP_SYNTHASE_2"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MAATHINTTNVAHNLQATTSLSKTQTPSIKSQPFLSFGPKHTNPIAHFSVSSNNNRNLGKKCLIVSAVATTEKPSTVPEIVLQPIKEISGTVNLPGSKSLSNRILLLAALAEGTTIVDNLLNSDDVHYMLGALRTLGLNVEEDGAIKRAIVEGCGGMFPVGKEAKDDIQLFLGNAGTAMRPLTAAVTAAGGNSSYVLDGVPRMRERPIGDLVTGLKQLGADVDCSLGTNCPPVRVVGGGGLPGGKVKLSGSISSQYLTALLMASPLALGDVEIEIIDKLISIPYVEMTLKLMEWFGVSVEHSDSWDRFFIRGGQKYKSPGNAYVEGDASSASYFLAGAAITGGTITVEGCGTSSLQGDVKFAEVLGQMGAEVTWTENSVTVKGPPRDSSGRKHLRAVDVNMNKMPDVAMTLAVVALYADGPTAIRDVASWRVKETERMIAICTELRKLGATVEEGPDYCVITPPEKLNVTAIDTYDDHRMAMAFSLAACADVPVTIKDPSCTRKTFPDYFEVLQRFAKH","length":519,"molWeight":55203,"crc64":"30C75A96A2D935C5","md5":"B16C46D0676589D82D6521784BF32798"},"extraAttributes":{"countByCommentType":{"CATALYTIC ACTIVITY":1,"PATHWAY":1,"SUBCELLULAR LOCATION":1,"SIMILARITY":1},"countByFeatureType":{"Domain":1},"uniParcId":"UPI00022BD08B"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"G4U4J5","uniProtkbId":"G4U4J5_ERICD","entryAudit":{"firstPublicDate":"2011-12-14","lastAnnotationUpdateDate":"2026-11-04","lastSequenceUpdateDate":"2011-12-14","entryVersion":47,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Erigeron canadensis","commonName":"Canadian horseweed","synonyms":["Conyza canadensis"],"taxonId":72917,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"CCB84815.1"}],"lineage":["Eukaryota","Viridiplantae","Streptophyta","Embryophyta","Tracheophyta","Spermatophyta","Magnoliopsida","eudicotyledons","Gunneridae","Pentapetalae","asterids","campanulids","Asterales","Asteraceae","Asteroideae","Astereae","North American clade","Conyzinae","Erigeron"]},"proteinExistence":"2: Evidence at transcript level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00012450"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU004164"}],"value":"3-phosphoshikimate 1-carboxyvinyltransferase"},"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00012450"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU004164"}],"value":"2.5.1.19"}]}},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"CCB84815.1"}],"value":"EPSPS-2"}}],"comments":[{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"3-phosphoshikimate + phosphoenolpyruvate = 5-O-(1-carboxyvinyl)-3-phosphoshikimate + phosphate","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:21256"},{"database":"ChEBI","id":"CHEBI:43474"},{"database":"ChEBI","id":"CHEBI:57701"},{"database":"ChEBI","id":"CHEBI:58702"},{"database":"ChEBI","id":"CHEBI:145989"}],"ecNumber":"2.5.1.19","evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00044633"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:21257"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00044633"}]}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004811"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU004164"}],"value":"Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 6/7"}],"commentType":"PATHWAY"},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004229"}],"value":"Plastid, chloroplast","id":"SL-0049"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00009948"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU004164"}],"value":"Belongs to the EPSP synthase family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Domain","location":{"start":{"value":87,"modifier":"EXACT"},"end":{"value":517,"modifier":"EXACT"}},"description":"Enolpyruvate transferase","evidences":[{"evidenceCode":"ECO:0000259","source":"Pfam","id":"PF00275"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022605"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU004164"}],"id":"KW-0028","category":"Biological process","name":"Amino-acid biosynthesis"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023141"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU004164"}],"id":"KW-0057","category":"Biological process","name":"Aromatic amino acid biosynthesis"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022528"}],"id":"KW-0150","category":"Cellular component","name":"Chloroplast"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022640"}],"id":"KW-0934","category":"Cellular component","name":"Plastid"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022679"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU004164"}],"id":"KW-0808","category":"Molecular function","name":"Transferase"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022946"}],"id":"KW-0809","category":"Domain","name":"Transit peptide"}],"references":[{"referenceNumber":1,"citation":{"id":"CI-3URMRHU5QF8MI","citationType":"submission","authors":["Nol N.","Livieratos I.","Giannopolitis C."],"title":"Reduced susceptibility to glyphosate of Conyza canadensis plants from a conventional citrus orchard in Crete (Greece) and early detection of resistance with the shikimate leaf disc assay.","publicationDate":"JUN-2011","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"CCB84815.1"}],"value":"B biotype","type":"STRAIN"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"CCB84815.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"FR872821","properties":[{"key":"ProteinId","value":"CCB84815.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"AlphaFoldDB","id":"G4U4J5","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"G4U4J5","properties":[{"key":"Description","value":"-"}]},{"database":"UniPathway","id":"UPA00053","properties":[{"key":"RectionId","value":"UER00089"}]},{"database":"GO","id":"GO:0009507","properties":[{"key":"GoTerm","value":"C:chloroplast"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0003866","properties":[{"key":"GoTerm","value":"F:3-phosphoshikimate 1-carboxyvinyltransferase activity"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniRule"}]},{"database":"GO","id":"GO:0009073","properties":[{"key":"GoTerm","value":"P:aromatic amino acid biosynthetic process"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniRule"}]},{"database":"GO","id":"GO:0009423","properties":[{"key":"GoTerm","value":"P:chorismate biosynthetic process"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniRule"}]},{"database":"CDD","id":"cd01556","properties":[{"key":"EntryName","value":"EPSP_synthase"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.65.10.10:FF:000004","properties":[{"key":"EntryName","value":"3-phosphoshikimate 1-carboxyvinyltransferase"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.65.10.10:FF:000009","properties":[{"key":"EntryName","value":"3-phosphoshikimate 1-carboxyvinyltransferase"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.65.10.10","properties":[{"key":"EntryName","value":"Enolpyruvate transferase domain"},{"key":"MatchStatus","value":"2"}]},{"database":"HAMAP","id":"MF_00210","properties":[{"key":"EntryName","value":"EPSP_synth"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR001986","properties":[{"key":"EntryName","value":"Enolpyruvate_Tfrase_dom"}]},{"database":"InterPro","id":"IPR036968","properties":[{"key":"EntryName","value":"Enolpyruvate_Tfrase_sf"}]},{"database":"InterPro","id":"IPR006264","properties":[{"key":"EntryName","value":"EPSP_synthase"}]},{"database":"InterPro","id":"IPR023193","properties":[{"key":"EntryName","value":"EPSP_synthase_CS"}]},{"database":"InterPro","id":"IPR013792","properties":[{"key":"EntryName","value":"RNA3'P_cycl/enolpyr_Trfase_a/b"}]},{"database":"NCBIfam","id":"TIGR01356","properties":[{"key":"EntryName","value":"aroA"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR21090","properties":[{"key":"EntryName","value":"AROM/DEHYDROQUINATE SYNTHASE"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR21090:SF5","properties":[{"key":"EntryName","value":"PENTAFUNCTIONAL AROM POLYPEPTIDE"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00275","properties":[{"key":"EntryName","value":"EPSP_synthase"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF55205","properties":[{"key":"EntryName","value":"EPT/RTPC-like"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00104","properties":[{"key":"EntryName","value":"EPSP_SYNTHASE_1"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00885","properties":[{"key":"EntryName","value":"EPSP_SYNTHASE_2"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MAVHINNSNIPIFNTSNLTTQNPSSKSSSFLSFGSNFKNPLRNNNNNNYTSVSCNVKNNKNPFKVSAFSATSTKEKPSKAPEEIVLKPIQEISGTVHLPGSKSLSNRILLLAALSEGTTVVDNLLNSDDVHYMLGALRVLGLNVEENSAIKRAIVEGCGGVFPVGKEAKDEVQLFLGNAGTAMRPLTAAVTAAGGNSSYILDGVPRMRERPIGDLVTGLKQLGANVDCSLGTNCPPVRVVGSGGLPGGKVKLSGSISSQYLTSLLMAAPLALGDVEIEIVDKLISVPYVEMTLKLMERFGVSVEHSDTWDRFHVRGGQKYKSPGNAYVEGDASSASYFLAGAAITGGTVTVEGCGTSSLQGDVKFAEVLGQMGAEVTWTENSVTVKGPPRNSSGRGHLRPVDVNMNKMPDVAMTLAVVALYADGPTAIRDVASWRVKETERMIAICTELRKLGATVEEGPDYCVITPPEKLNVTAIDTYDDHRMAMAFSLAACAEVPVTIKDPGCTRKTFPDYFEVLERYTKH","length":523,"molWeight":55854,"crc64":"97AAB2EDFFA4DFD7","md5":"8AD77F6447F3ACC45301F5FEE683CD78"},"extraAttributes":{"countByCommentType":{"CATALYTIC ACTIVITY":1,"PATHWAY":1,"SUBCELLULAR LOCATION":1,"SIMILARITY":1},"countByFeatureType":{"Domain":1},"uniParcId":"UPI00022BD08C"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"G4VV17","uniProtkbId":"G4VV17_ERICD","entryAudit":{"firstPublicDate":"2011-12-14","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2011-12-14","entryVersion":62,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Erigeron canadensis","commonName":"Canadian horseweed","synonyms":["Conyza canadensis"],"taxonId":72917,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ADN95986.1"}],"lineage":["Eukaryota","Viridiplantae","Streptophyta","Embryophyta","Tracheophyta","Spermatophyta","Magnoliopsida","eudicotyledons","Gunneridae","Pentapetalae","asterids","campanulids","Asterales","Asteraceae","Asteroideae","Astereae","North American clade","Conyzinae","Erigeron"]},"proteinExistence":"3: Inferred from homology","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00013145"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003591"}],"value":"Acetolactate synthase"},"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00013145"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003591"}],"value":"2.2.1.6"}]},"flag":"Fragment"},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ADN95986.1"}],"value":"ALS"}}],"comments":[{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"2 pyruvate + H(+) = (2S)-2-acetolactate + CO2","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:25249"},{"database":"ChEBI","id":"CHEBI:15361"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:16526"},{"database":"ChEBI","id":"CHEBI:58476"}],"ecNumber":"2.2.1.6","evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00048670"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003591"}]}},{"commentType":"COFACTOR","cofactors":[{"name":"Mg(2+)","evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003591"}],"cofactorCrossReference":{"database":"ChEBI","id":"CHEBI:18420"}}],"note":{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003591"}],"value":"Binds 1 Mg(2+) ion per subunit."}]}},{"commentType":"COFACTOR","cofactors":[{"name":"thiamine diphosphate","evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003591"}],"cofactorCrossReference":{"database":"ChEBI","id":"CHEBI:58937"}}],"note":{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003591"}],"value":"Binds 1 thiamine pyrophosphate per subunit."}]}},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004974"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003591"}],"value":"Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 1/4"}],"commentType":"PATHWAY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00005025"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003591"}],"value":"Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 1/4"}],"commentType":"PATHWAY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00007812"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003591"}],"value":"Belongs to the TPP enzyme family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Domain","location":{"start":{"value":33,"modifier":"EXACT"},"end":{"value":143,"modifier":"EXACT"}},"description":"Thiamine pyrophosphate enzyme N-terminal TPP-binding","evidences":[{"evidenceCode":"ECO:0000259","source":"Pfam","id":"PF02776"}]},{"type":"Domain","location":{"start":{"value":224,"modifier":"EXACT"},"end":{"value":357,"modifier":"EXACT"}},"description":"Thiamine pyrophosphate enzyme central","evidences":[{"evidenceCode":"ECO:0000259","source":"Pfam","id":"PF00205"}]},{"type":"Domain","location":{"start":{"value":419,"modifier":"EXACT"},"end":{"value":574,"modifier":"EXACT"}},"description":"Thiamine pyrophosphate enzyme TPP-binding","evidences":[{"evidenceCode":"ECO:0000259","source":"Pfam","id":"PF02775"}]},{"type":"Region","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":29,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Non-terminal residue","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":1,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ADN95986.1"}]},{"type":"Non-terminal residue","location":{"start":{"value":605,"modifier":"EXACT"},"end":{"value":605,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ADN95986.1"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022605"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003591"}],"id":"KW-0028","category":"Biological process","name":"Amino-acid biosynthesis"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023304"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003591"}],"id":"KW-0100","category":"Biological process","name":"Branched-chain amino acid biosynthesis"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022827"}],"id":"KW-0274","category":"Ligand","name":"FAD"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022630"}],"id":"KW-0285","category":"Ligand","name":"Flavoprotein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022646"}],"id":"KW-0359","category":"Biological process","name":"Herbicide resistance"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022842"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003591"}],"id":"KW-0460","category":"Ligand","name":"Magnesium"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022723"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003591"}],"id":"KW-0479","category":"Ligand","name":"Metal-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023052"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003591"}],"id":"KW-0786","category":"Ligand","name":"Thiamine pyrophosphate"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022679"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003591"}],"id":"KW-0808","category":"Molecular function","name":"Transferase"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022946"}],"id":"KW-0809","category":"Domain","name":"Transit peptide"}],"references":[{"referenceNumber":1,"citation":{"id":"21538801","citationType":"journal article","authors":["Zheng D.","Kruger G.R.","Singh S.","Davis V.M.","Tranel P.J.","Weller S.C.","Johnson W.G."],"citationCrossReferences":[{"database":"PubMed","id":"21538801"},{"database":"DOI","id":"10.1002/ps.2190"}],"title":"Cross-resistance of horseweed (Conyza canadensis) populations with three different ALS mutations.","publicationDate":"2011","journal":"Pest Manag. Sci.","firstPage":"1486","lastPage":"1492","volume":"67"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ADN95986.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"HM067014","properties":[{"key":"ProteinId","value":"ADN95986.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"AlphaFoldDB","id":"G4VV17","properties":[{"key":"Description","value":"-"}]},{"database":"UniPathway","id":"UPA00047","properties":[{"key":"RectionId","value":"UER00055"}]},{"database":"UniPathway","id":"UPA00049","properties":[{"key":"RectionId","value":"UER00059"}]},{"database":"GO","id":"GO:0005948","properties":[{"key":"GoTerm","value":"C:acetolactate synthase complex"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:0003984","properties":[{"key":"GoTerm","value":"F:acetolactate synthase activity"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-EC"}]},{"database":"GO","id":"GO:0050660","properties":[{"key":"GoTerm","value":"F:flavin adenine dinucleotide binding"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0000287","properties":[{"key":"GoTerm","value":"F:magnesium ion binding"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniRule"}]},{"database":"GO","id":"GO:0030976","properties":[{"key":"GoTerm","value":"F:thiamine pyrophosphate binding"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniRule"}]},{"database":"GO","id":"GO:0009099","properties":[{"key":"GoTerm","value":"P:L-valine biosynthetic process"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniPathway"}]},{"database":"CDD","id":"cd02015","properties":[{"key":"EntryName","value":"TPP_AHAS"},{"key":"MatchStatus","value":"1"}]},{"database":"CDD","id":"cd07035","properties":[{"key":"EntryName","value":"TPP_PYR_POX_like"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.40.50.1220:FF:000008","properties":[{"key":"EntryName","value":"Acetolactate synthase"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.40.50.970:FF:000007","properties":[{"key":"EntryName","value":"Acetolactate synthase"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.40.50.970:FF:000053","properties":[{"key":"EntryName","value":"Acetolactate synthase, mitochondrial"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.40.50.970","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"2"}]},{"database":"Gene3D","id":"3.40.50.1220","properties":[{"key":"EntryName","value":"TPP-binding domain"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR012846","properties":[{"key":"EntryName","value":"Acetolactate_synth_lsu"}]},{"database":"InterPro","id":"IPR039368","properties":[{"key":"EntryName","value":"AHAS_TPP"}]},{"database":"InterPro","id":"IPR029035","properties":[{"key":"EntryName","value":"DHS-like_NAD/FAD-binding_dom"}]},{"database":"InterPro","id":"IPR029061","properties":[{"key":"EntryName","value":"THDP-binding"}]},{"database":"InterPro","id":"IPR012000","properties":[{"key":"EntryName","value":"Thiamin_PyroP_enz_cen_dom"}]},{"database":"InterPro","id":"IPR012001","properties":[{"key":"EntryName","value":"Thiamin_PyroP_enz_TPP-bd_dom"}]},{"database":"InterPro","id":"IPR000399","properties":[{"key":"EntryName","value":"TPP-bd_CS"}]},{"database":"InterPro","id":"IPR045229","properties":[{"key":"EntryName","value":"TPP_enz"}]},{"database":"InterPro","id":"IPR011766","properties":[{"key":"EntryName","value":"TPP_enzyme_TPP-bd"}]},{"database":"NCBIfam","id":"TIGR00118","properties":[{"key":"EntryName","value":"acolac_lg"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR18968:SF13","properties":[{"key":"EntryName","value":"ACETOLACTATE SYNTHASE CATALYTIC SUBUNIT, MITOCHONDRIAL"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR18968","properties":[{"key":"EntryName","value":"THIAMINE PYROPHOSPHATE ENZYMES"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF02775","properties":[{"key":"EntryName","value":"TPP_enzyme_C"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00205","properties":[{"key":"EntryName","value":"TPP_enzyme_M"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF02776","properties":[{"key":"EntryName","value":"TPP_enzyme_N"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF52467","properties":[{"key":"EntryName","value":"DHS-like NAD/FAD-binding domain"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF52518","properties":[{"key":"EntryName","value":"Thiamin diphosphate-binding fold (THDP-binding)"},{"key":"MatchStatus","value":"2"}]},{"database":"PROSITE","id":"PS00187","properties":[{"key":"EntryName","value":"TPP_ENZYMES"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"IQSSGHKPITTTTTTTVPPPSFTSRFAADQPRKGSDVLVEALEREGVTDVFAYPGGASMEIHQALTRSTTIRNVLPRHEQGGIFAAEGYARASGLPGVCIATSGPGATNLVSGLADALLDSVPVVAITGQVPRRMIGTDAFQETPIVEVTRSITKHNYLVLDVDDIPRIVREAFYLARSGRPGPVLIDIPKDIQQQLCVPKWDEPMRLPGYLSRLPKPPNDGLLEQIVRLVGESKRPVLYVGGGCLNSSDELRRFVELTGIPVASTLMGLGSYPASSDLSLQMLGMHGTVYANYAVDKADLLLAFGVRFDDRVTGKLEAFASRAKIVHIDIDSAEIGKNKQPHVSVCGDIKIALQGLNKILEGRREMSNLDFSAWRAELDEQKVNHPLSFKTFGEAIPPQYAIQVLDELTGGNAIISTGVGQHQMWAAQFYKYNRPRQWLTSGGLGAMGFGLPAAIGAAVARPDAVVVDIDGDGSFIMNVQELATIRVENLPVKVLLLNNQHLGMVVQWEDRFYKANRAHTYLGNPSKEAEIFPNMLKFAEACDIPAARVTRKADLRAAIQKMLDTPGPYLLDVIVPHQEHVLPMIPAGGGFMDVITEGDGRTKY","length":605,"molWeight":65715,"crc64":"F2EF6646295D996D","md5":"6FCF678821880BF279EC926DD7655325"},"extraAttributes":{"countByCommentType":{"CATALYTIC ACTIVITY":1,"COFACTOR":2,"PATHWAY":2,"SIMILARITY":1},"countByFeatureType":{"Domain":3,"Region":1,"Non-terminal residue":2},"uniParcId":"UPI00022AB46D"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"G8E459","uniProtkbId":"G8E459_ERICD","entryAudit":{"firstPublicDate":"2012-01-25","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2012-01-25","entryVersion":60,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Erigeron canadensis","commonName":"Canadian horseweed","synonyms":["Conyza canadensis"],"taxonId":72917,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AEE68993.1"}],"lineage":["Eukaryota","Viridiplantae","Streptophyta","Embryophyta","Tracheophyta","Spermatophyta","Magnoliopsida","eudicotyledons","Gunneridae","Pentapetalae","asterids","campanulids","Asterales","Asteraceae","Asteroideae","Astereae","North American clade","Conyzinae","Erigeron"]},"proteinExistence":"3: Inferred from homology","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00013145"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003591"}],"value":"Acetolactate synthase"},"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00013145"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003591"}],"value":"2.2.1.6"}]},"flag":"Fragment"},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AEE68993.1"}],"value":"ALS"}}],"comments":[{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"2 pyruvate + H(+) = (2S)-2-acetolactate + CO2","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:25249"},{"database":"ChEBI","id":"CHEBI:15361"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:16526"},{"database":"ChEBI","id":"CHEBI:58476"}],"ecNumber":"2.2.1.6","evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00048670"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003591"}]}},{"commentType":"COFACTOR","cofactors":[{"name":"Mg(2+)","evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003591"}],"cofactorCrossReference":{"database":"ChEBI","id":"CHEBI:18420"}}],"note":{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003591"}],"value":"Binds 1 Mg(2+) ion per subunit."}]}},{"commentType":"COFACTOR","cofactors":[{"name":"thiamine diphosphate","evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003591"}],"cofactorCrossReference":{"database":"ChEBI","id":"CHEBI:58937"}}],"note":{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003591"}],"value":"Binds 1 thiamine pyrophosphate per subunit."}]}},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004974"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003591"}],"value":"Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 1/4"}],"commentType":"PATHWAY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00005025"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003591"}],"value":"Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 1/4"}],"commentType":"PATHWAY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00007812"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003591"}],"value":"Belongs to the TPP enzyme family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Domain","location":{"start":{"value":2,"modifier":"EXACT"},"end":{"value":101,"modifier":"EXACT"}},"description":"Thiamine pyrophosphate enzyme N-terminal TPP-binding","evidences":[{"evidenceCode":"ECO:0000259","source":"Pfam","id":"PF02776"}]},{"type":"Domain","location":{"start":{"value":182,"modifier":"EXACT"},"end":{"value":315,"modifier":"EXACT"}},"description":"Thiamine pyrophosphate enzyme central","evidences":[{"evidenceCode":"ECO:0000259","source":"Pfam","id":"PF00205"}]},{"type":"Domain","location":{"start":{"value":377,"modifier":"EXACT"},"end":{"value":532,"modifier":"EXACT"}},"description":"Thiamine pyrophosphate enzyme TPP-binding","evidences":[{"evidenceCode":"ECO:0000259","source":"Pfam","id":"PF02775"}]},{"type":"Non-terminal residue","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":1,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AEE68993.1"}]},{"type":"Non-terminal residue","location":{"start":{"value":557,"modifier":"EXACT"},"end":{"value":557,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AEE68993.1"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022605"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003591"}],"id":"KW-0028","category":"Biological process","name":"Amino-acid biosynthesis"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023304"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003591"}],"id":"KW-0100","category":"Biological process","name":"Branched-chain amino acid biosynthesis"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022827"}],"id":"KW-0274","category":"Ligand","name":"FAD"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022630"}],"id":"KW-0285","category":"Ligand","name":"Flavoprotein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022646"}],"id":"KW-0359","category":"Biological process","name":"Herbicide resistance"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022842"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003591"}],"id":"KW-0460","category":"Ligand","name":"Magnesium"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022723"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003591"}],"id":"KW-0479","category":"Ligand","name":"Metal-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023052"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003591"}],"id":"KW-0786","category":"Ligand","name":"Thiamine pyrophosphate"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022679"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003591"}],"id":"KW-0808","category":"Molecular function","name":"Transferase"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022946"}],"id":"KW-0809","category":"Domain","name":"Transit peptide"}],"references":[{"referenceNumber":1,"citation":{"id":"21538801","citationType":"journal article","authors":["Zheng D.","Kruger G.R.","Singh S.","Davis V.M.","Tranel P.J.","Weller S.C.","Johnson W.G."],"citationCrossReferences":[{"database":"PubMed","id":"21538801"},{"database":"DOI","id":"10.1002/ps.2190"}],"title":"Cross-resistance of horseweed (Conyza canadensis) populations with three different ALS mutations.","publicationDate":"2011","journal":"Pest Manag. Sci.","firstPage":"1486","lastPage":"1492","volume":"67"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AEE68993.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"JF719123","properties":[{"key":"ProteinId","value":"AEE68993.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"UniPathway","id":"UPA00047","properties":[{"key":"RectionId","value":"UER00055"}]},{"database":"UniPathway","id":"UPA00049","properties":[{"key":"RectionId","value":"UER00059"}]},{"database":"GO","id":"GO:0005948","properties":[{"key":"GoTerm","value":"C:acetolactate synthase complex"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:0003984","properties":[{"key":"GoTerm","value":"F:acetolactate synthase activity"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-EC"}]},{"database":"GO","id":"GO:0050660","properties":[{"key":"GoTerm","value":"F:flavin adenine dinucleotide binding"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0000287","properties":[{"key":"GoTerm","value":"F:magnesium ion binding"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniRule"}]},{"database":"GO","id":"GO:0030976","properties":[{"key":"GoTerm","value":"F:thiamine pyrophosphate binding"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniRule"}]},{"database":"GO","id":"GO:0009099","properties":[{"key":"GoTerm","value":"P:L-valine biosynthetic process"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniPathway"}]},{"database":"CDD","id":"cd02015","properties":[{"key":"EntryName","value":"TPP_AHAS"},{"key":"MatchStatus","value":"1"}]},{"database":"CDD","id":"cd07035","properties":[{"key":"EntryName","value":"TPP_PYR_POX_like"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.40.50.1220:FF:000008","properties":[{"key":"EntryName","value":"Acetolactate synthase"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.40.50.970:FF:000007","properties":[{"key":"EntryName","value":"Acetolactate synthase"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.40.50.970:FF:000053","properties":[{"key":"EntryName","value":"Acetolactate synthase, mitochondrial"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.40.50.970","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"2"}]},{"database":"Gene3D","id":"3.40.50.1220","properties":[{"key":"EntryName","value":"TPP-binding domain"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR012846","properties":[{"key":"EntryName","value":"Acetolactate_synth_lsu"}]},{"database":"InterPro","id":"IPR039368","properties":[{"key":"EntryName","value":"AHAS_TPP"}]},{"database":"InterPro","id":"IPR029035","properties":[{"key":"EntryName","value":"DHS-like_NAD/FAD-binding_dom"}]},{"database":"InterPro","id":"IPR029061","properties":[{"key":"EntryName","value":"THDP-binding"}]},{"database":"InterPro","id":"IPR012000","properties":[{"key":"EntryName","value":"Thiamin_PyroP_enz_cen_dom"}]},{"database":"InterPro","id":"IPR012001","properties":[{"key":"EntryName","value":"Thiamin_PyroP_enz_TPP-bd_dom"}]},{"database":"InterPro","id":"IPR000399","properties":[{"key":"EntryName","value":"TPP-bd_CS"}]},{"database":"InterPro","id":"IPR045229","properties":[{"key":"EntryName","value":"TPP_enz"}]},{"database":"InterPro","id":"IPR011766","properties":[{"key":"EntryName","value":"TPP_enzyme_TPP-bd"}]},{"database":"NCBIfam","id":"TIGR00118","properties":[{"key":"EntryName","value":"acolac_lg"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR18968:SF13","properties":[{"key":"EntryName","value":"ACETOLACTATE SYNTHASE CATALYTIC SUBUNIT, MITOCHONDRIAL"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR18968","properties":[{"key":"EntryName","value":"THIAMINE PYROPHOSPHATE ENZYMES"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF02775","properties":[{"key":"EntryName","value":"TPP_enzyme_C"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00205","properties":[{"key":"EntryName","value":"TPP_enzyme_M"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF02776","properties":[{"key":"EntryName","value":"TPP_enzyme_N"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF52467","properties":[{"key":"EntryName","value":"DHS-like NAD/FAD-binding domain"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF52518","properties":[{"key":"EntryName","value":"Thiamin diphosphate-binding fold (THDP-binding)"},{"key":"MatchStatus","value":"2"}]},{"database":"PROSITE","id":"PS00187","properties":[{"key":"EntryName","value":"TPP_ENZYMES"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"EREGVTDVFAYPGGASMEIHQALTRSTTIRNVLPRHEQGGIFAAEGYARASGLPGVCIATSGPGATNLVSGLADALLDSVPVVAITGQVSRRMIGTDAFQETPIVEVTRSITKHNYLVLDVDDIPRIVREAFYLARSGRPGPVLIDIPKDIQQQLCVPKWDEPMRLPGYLSRLPKPPNDGLLEQIVRLVGESKRPVLYVGGGCLNSSDELRRFVELTGIPVASTLMGLGSYPASSDLSLQMLGMHGTVYANYAVDKADLLLAFGVRFDDRVTGKLEAFASRAKIVHIDIDSAEIGKNKQPHVSVCGDIKIALQGLNKILEGRREMSNLDFSAWRAELDEQKVNHPLSFKTFGEAIPPQYAIXVLDELTGGNAIISTGVGQHQMWAAQFYKYNRPRQWLTSGGLGAMGFGLPAAIGAAVARPDAVVVDIDGDGSFIMNVQELATIRVENLPVKVLLLNNQHLGMVVQWEDRFYKANRAHTYLGNPSKEAEIFPNMLKFAEACDIPAARVTRKADLRAAIQKMLDTPGPYLLDVIVPHQEHVLPMIPAGGGFMDVITEG","length":557,"molWeight":60545,"crc64":"2AB26CD4C2BF1A76","md5":"D68AF5374B09C21255BEB84922D6BF98"},"extraAttributes":{"countByCommentType":{"CATALYTIC ACTIVITY":1,"COFACTOR":2,"PATHWAY":2,"SIMILARITY":1},"countByFeatureType":{"Domain":3,"Non-terminal residue":2},"uniParcId":"UPI000231E77D"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"G8E460","uniProtkbId":"G8E460_ERICD","entryAudit":{"firstPublicDate":"2012-01-25","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2012-01-25","entryVersion":60,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Erigeron canadensis","commonName":"Canadian horseweed","synonyms":["Conyza canadensis"],"taxonId":72917,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AEE68994.1"}],"lineage":["Eukaryota","Viridiplantae","Streptophyta","Embryophyta","Tracheophyta","Spermatophyta","Magnoliopsida","eudicotyledons","Gunneridae","Pentapetalae","asterids","campanulids","Asterales","Asteraceae","Asteroideae","Astereae","North American clade","Conyzinae","Erigeron"]},"proteinExistence":"3: Inferred from homology","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00013145"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003591"}],"value":"Acetolactate synthase"},"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00013145"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003591"}],"value":"2.2.1.6"}]},"flag":"Fragment"},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AEE68994.1"}],"value":"ALS"}}],"comments":[{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"2 pyruvate + H(+) = (2S)-2-acetolactate + CO2","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:25249"},{"database":"ChEBI","id":"CHEBI:15361"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:16526"},{"database":"ChEBI","id":"CHEBI:58476"}],"ecNumber":"2.2.1.6","evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00048670"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003591"}]}},{"commentType":"COFACTOR","cofactors":[{"name":"Mg(2+)","evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003591"}],"cofactorCrossReference":{"database":"ChEBI","id":"CHEBI:18420"}}],"note":{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003591"}],"value":"Binds 1 Mg(2+) ion per subunit."}]}},{"commentType":"COFACTOR","cofactors":[{"name":"thiamine diphosphate","evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003591"}],"cofactorCrossReference":{"database":"ChEBI","id":"CHEBI:58937"}}],"note":{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003591"}],"value":"Binds 1 thiamine pyrophosphate per subunit."}]}},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004974"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003591"}],"value":"Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 1/4"}],"commentType":"PATHWAY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00005025"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003591"}],"value":"Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 1/4"}],"commentType":"PATHWAY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00007812"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003591"}],"value":"Belongs to the TPP enzyme family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Domain","location":{"start":{"value":2,"modifier":"EXACT"},"end":{"value":101,"modifier":"EXACT"}},"description":"Thiamine pyrophosphate enzyme N-terminal TPP-binding","evidences":[{"evidenceCode":"ECO:0000259","source":"Pfam","id":"PF02776"}]},{"type":"Domain","location":{"start":{"value":182,"modifier":"EXACT"},"end":{"value":315,"modifier":"EXACT"}},"description":"Thiamine pyrophosphate enzyme central","evidences":[{"evidenceCode":"ECO:0000259","source":"Pfam","id":"PF00205"}]},{"type":"Domain","location":{"start":{"value":377,"modifier":"EXACT"},"end":{"value":532,"modifier":"EXACT"}},"description":"Thiamine pyrophosphate enzyme TPP-binding","evidences":[{"evidenceCode":"ECO:0000259","source":"Pfam","id":"PF02775"}]},{"type":"Non-terminal residue","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":1,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AEE68994.1"}]},{"type":"Non-terminal residue","location":{"start":{"value":557,"modifier":"EXACT"},"end":{"value":557,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AEE68994.1"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022605"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003591"}],"id":"KW-0028","category":"Biological process","name":"Amino-acid biosynthesis"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023304"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003591"}],"id":"KW-0100","category":"Biological process","name":"Branched-chain amino acid biosynthesis"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022827"}],"id":"KW-0274","category":"Ligand","name":"FAD"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022630"}],"id":"KW-0285","category":"Ligand","name":"Flavoprotein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022646"}],"id":"KW-0359","category":"Biological process","name":"Herbicide resistance"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022842"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003591"}],"id":"KW-0460","category":"Ligand","name":"Magnesium"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022723"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003591"}],"id":"KW-0479","category":"Ligand","name":"Metal-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023052"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003591"}],"id":"KW-0786","category":"Ligand","name":"Thiamine pyrophosphate"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022679"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003591"}],"id":"KW-0808","category":"Molecular function","name":"Transferase"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022946"}],"id":"KW-0809","category":"Domain","name":"Transit peptide"}],"references":[{"referenceNumber":1,"citation":{"id":"21538801","citationType":"journal article","authors":["Zheng D.","Kruger G.R.","Singh S.","Davis V.M.","Tranel P.J.","Weller S.C.","Johnson W.G."],"citationCrossReferences":[{"database":"PubMed","id":"21538801"},{"database":"DOI","id":"10.1002/ps.2190"}],"title":"Cross-resistance of horseweed (Conyza canadensis) populations with three different ALS mutations.","publicationDate":"2011","journal":"Pest Manag. Sci.","firstPage":"1486","lastPage":"1492","volume":"67"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AEE68994.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"JF719124","properties":[{"key":"ProteinId","value":"AEE68994.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"UniPathway","id":"UPA00047","properties":[{"key":"RectionId","value":"UER00055"}]},{"database":"UniPathway","id":"UPA00049","properties":[{"key":"RectionId","value":"UER00059"}]},{"database":"GO","id":"GO:0005948","properties":[{"key":"GoTerm","value":"C:acetolactate synthase complex"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:0003984","properties":[{"key":"GoTerm","value":"F:acetolactate synthase activity"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-EC"}]},{"database":"GO","id":"GO:0050660","properties":[{"key":"GoTerm","value":"F:flavin adenine dinucleotide binding"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0000287","properties":[{"key":"GoTerm","value":"F:magnesium ion binding"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniRule"}]},{"database":"GO","id":"GO:0030976","properties":[{"key":"GoTerm","value":"F:thiamine pyrophosphate binding"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniRule"}]},{"database":"GO","id":"GO:0009099","properties":[{"key":"GoTerm","value":"P:L-valine biosynthetic process"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniPathway"}]},{"database":"CDD","id":"cd02015","properties":[{"key":"EntryName","value":"TPP_AHAS"},{"key":"MatchStatus","value":"1"}]},{"database":"CDD","id":"cd07035","properties":[{"key":"EntryName","value":"TPP_PYR_POX_like"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.40.50.1220:FF:000008","properties":[{"key":"EntryName","value":"Acetolactate synthase"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.40.50.970:FF:000007","properties":[{"key":"EntryName","value":"Acetolactate synthase"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.40.50.970:FF:000053","properties":[{"key":"EntryName","value":"Acetolactate synthase, mitochondrial"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.40.50.970","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"2"}]},{"database":"Gene3D","id":"3.40.50.1220","properties":[{"key":"EntryName","value":"TPP-binding domain"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR012846","properties":[{"key":"EntryName","value":"Acetolactate_synth_lsu"}]},{"database":"InterPro","id":"IPR039368","properties":[{"key":"EntryName","value":"AHAS_TPP"}]},{"database":"InterPro","id":"IPR029035","properties":[{"key":"EntryName","value":"DHS-like_NAD/FAD-binding_dom"}]},{"database":"InterPro","id":"IPR029061","properties":[{"key":"EntryName","value":"THDP-binding"}]},{"database":"InterPro","id":"IPR012000","properties":[{"key":"EntryName","value":"Thiamin_PyroP_enz_cen_dom"}]},{"database":"InterPro","id":"IPR012001","properties":[{"key":"EntryName","value":"Thiamin_PyroP_enz_TPP-bd_dom"}]},{"database":"InterPro","id":"IPR000399","properties":[{"key":"EntryName","value":"TPP-bd_CS"}]},{"database":"InterPro","id":"IPR045229","properties":[{"key":"EntryName","value":"TPP_enz"}]},{"database":"InterPro","id":"IPR011766","properties":[{"key":"EntryName","value":"TPP_enzyme_TPP-bd"}]},{"database":"NCBIfam","id":"TIGR00118","properties":[{"key":"EntryName","value":"acolac_lg"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR18968:SF13","properties":[{"key":"EntryName","value":"ACETOLACTATE SYNTHASE CATALYTIC SUBUNIT, MITOCHONDRIAL"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR18968","properties":[{"key":"EntryName","value":"THIAMINE PYROPHOSPHATE ENZYMES"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF02775","properties":[{"key":"EntryName","value":"TPP_enzyme_C"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00205","properties":[{"key":"EntryName","value":"TPP_enzyme_M"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF02776","properties":[{"key":"EntryName","value":"TPP_enzyme_N"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF52467","properties":[{"key":"EntryName","value":"DHS-like NAD/FAD-binding domain"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF52518","properties":[{"key":"EntryName","value":"Thiamin diphosphate-binding fold (THDP-binding)"},{"key":"MatchStatus","value":"2"}]},{"database":"PROSITE","id":"PS00187","properties":[{"key":"EntryName","value":"TPP_ENZYMES"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"EREGVTDVFAYPGGASMEIHQALTRSTTIRNVLPRHEQGGIFAAEGYARASGLPGVCIATSGPGATNLVSGLADALLDSVPVVAITGQVARRMIGTDAFQETPIVEVTRSITKHNYLVLDVDDIPRIVREAFYLARSGRPGPVLIDIPKDIQQQLCVPKWDEPMRLPGYLSRLPKPPNDGLLEQIVRLVGESKRPVLYVGGGCLNSSDELRRFVELTGIPVASTLMGLGSYPASSDLSLQMLGMHGTVYANYAVDKADLLLAFGVRFDDRVTGKLEAFASRAKIVHIDIDSAEIGKNKQPHVSVCGDIKIALQGLNKILEGRREMSNLDFSAWRAELDEQKVNHPLSFKTFGEAIPPQYAIXVLDELTGGNAIISTGVGQHQMWAAQFYKYNRPRQWLTSGGLGAMGFGLPAAIGAAVARPDAVVVDIDGDGSFIMNVQELATIRVENLPVKVLLLNNQHLGMVVQWEDRFYKANRAHTYLGNPSKEAEIFPNMLKFAEACDIPAARVTRKADLRAAIQKMLDTPGPYLLDVIVPHQEHVLPMIPAGGGFMDVITEG","length":557,"molWeight":60529,"crc64":"9DFC2B06FF82D7B4","md5":"92E7DEF947C0E324BD7FDE7E9D121557"},"extraAttributes":{"countByCommentType":{"CATALYTIC ACTIVITY":1,"COFACTOR":2,"PATHWAY":2,"SIMILARITY":1},"countByFeatureType":{"Domain":3,"Non-terminal residue":2},"uniParcId":"UPI000231E77E"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"G8E461","uniProtkbId":"G8E461_ERICD","entryAudit":{"firstPublicDate":"2012-01-25","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2012-01-25","entryVersion":60,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Erigeron canadensis","commonName":"Canadian horseweed","synonyms":["Conyza canadensis"],"taxonId":72917,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AEE68995.1"}],"lineage":["Eukaryota","Viridiplantae","Streptophyta","Embryophyta","Tracheophyta","Spermatophyta","Magnoliopsida","eudicotyledons","Gunneridae","Pentapetalae","asterids","campanulids","Asterales","Asteraceae","Asteroideae","Astereae","North American clade","Conyzinae","Erigeron"]},"proteinExistence":"3: Inferred from homology","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00013145"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003591"}],"value":"Acetolactate synthase"},"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00013145"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003591"}],"value":"2.2.1.6"}]},"flag":"Fragment"},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AEE68995.1"}],"value":"ALS"}}],"comments":[{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"2 pyruvate + H(+) = (2S)-2-acetolactate + CO2","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:25249"},{"database":"ChEBI","id":"CHEBI:15361"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:16526"},{"database":"ChEBI","id":"CHEBI:58476"}],"ecNumber":"2.2.1.6","evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00048670"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003591"}]}},{"commentType":"COFACTOR","cofactors":[{"name":"Mg(2+)","evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003591"}],"cofactorCrossReference":{"database":"ChEBI","id":"CHEBI:18420"}}],"note":{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003591"}],"value":"Binds 1 Mg(2+) ion per subunit."}]}},{"commentType":"COFACTOR","cofactors":[{"name":"thiamine diphosphate","evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003591"}],"cofactorCrossReference":{"database":"ChEBI","id":"CHEBI:58937"}}],"note":{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003591"}],"value":"Binds 1 thiamine pyrophosphate per subunit."}]}},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004974"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003591"}],"value":"Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 1/4"}],"commentType":"PATHWAY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00005025"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003591"}],"value":"Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 1/4"}],"commentType":"PATHWAY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00007812"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003591"}],"value":"Belongs to the TPP enzyme family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Domain","location":{"start":{"value":2,"modifier":"EXACT"},"end":{"value":101,"modifier":"EXACT"}},"description":"Thiamine pyrophosphate enzyme N-terminal TPP-binding","evidences":[{"evidenceCode":"ECO:0000259","source":"Pfam","id":"PF02776"}]},{"type":"Domain","location":{"start":{"value":182,"modifier":"EXACT"},"end":{"value":315,"modifier":"EXACT"}},"description":"Thiamine pyrophosphate enzyme central","evidences":[{"evidenceCode":"ECO:0000259","source":"Pfam","id":"PF00205"}]},{"type":"Domain","location":{"start":{"value":377,"modifier":"EXACT"},"end":{"value":532,"modifier":"EXACT"}},"description":"Thiamine pyrophosphate enzyme TPP-binding","evidences":[{"evidenceCode":"ECO:0000259","source":"Pfam","id":"PF02775"}]},{"type":"Non-terminal residue","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":1,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AEE68995.1"}]},{"type":"Non-terminal residue","location":{"start":{"value":557,"modifier":"EXACT"},"end":{"value":557,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AEE68995.1"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022605"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003591"}],"id":"KW-0028","category":"Biological process","name":"Amino-acid biosynthesis"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023304"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003591"}],"id":"KW-0100","category":"Biological process","name":"Branched-chain amino acid biosynthesis"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022827"}],"id":"KW-0274","category":"Ligand","name":"FAD"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022630"}],"id":"KW-0285","category":"Ligand","name":"Flavoprotein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022646"}],"id":"KW-0359","category":"Biological process","name":"Herbicide resistance"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022842"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003591"}],"id":"KW-0460","category":"Ligand","name":"Magnesium"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022723"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003591"}],"id":"KW-0479","category":"Ligand","name":"Metal-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023052"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003591"}],"id":"KW-0786","category":"Ligand","name":"Thiamine pyrophosphate"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022679"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003591"}],"id":"KW-0808","category":"Molecular function","name":"Transferase"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022946"}],"id":"KW-0809","category":"Domain","name":"Transit peptide"}],"references":[{"referenceNumber":1,"citation":{"id":"21538801","citationType":"journal article","authors":["Zheng D.","Kruger G.R.","Singh S.","Davis V.M.","Tranel P.J.","Weller S.C.","Johnson W.G."],"citationCrossReferences":[{"database":"PubMed","id":"21538801"},{"database":"DOI","id":"10.1002/ps.2190"}],"title":"Cross-resistance of horseweed (Conyza canadensis) populations with three different ALS mutations.","publicationDate":"2011","journal":"Pest Manag. Sci.","firstPage":"1486","lastPage":"1492","volume":"67"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AEE68995.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"JF719125","properties":[{"key":"ProteinId","value":"AEE68995.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"UniPathway","id":"UPA00047","properties":[{"key":"RectionId","value":"UER00055"}]},{"database":"UniPathway","id":"UPA00049","properties":[{"key":"RectionId","value":"UER00059"}]},{"database":"GO","id":"GO:0005948","properties":[{"key":"GoTerm","value":"C:acetolactate synthase complex"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:0003984","properties":[{"key":"GoTerm","value":"F:acetolactate synthase activity"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-EC"}]},{"database":"GO","id":"GO:0050660","properties":[{"key":"GoTerm","value":"F:flavin adenine dinucleotide binding"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0000287","properties":[{"key":"GoTerm","value":"F:magnesium ion binding"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniRule"}]},{"database":"GO","id":"GO:0030976","properties":[{"key":"GoTerm","value":"F:thiamine pyrophosphate binding"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniRule"}]},{"database":"GO","id":"GO:0009099","properties":[{"key":"GoTerm","value":"P:L-valine biosynthetic process"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniPathway"}]},{"database":"CDD","id":"cd02015","properties":[{"key":"EntryName","value":"TPP_AHAS"},{"key":"MatchStatus","value":"1"}]},{"database":"CDD","id":"cd07035","properties":[{"key":"EntryName","value":"TPP_PYR_POX_like"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.40.50.1220:FF:000008","properties":[{"key":"EntryName","value":"Acetolactate synthase"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.40.50.970:FF:000007","properties":[{"key":"EntryName","value":"Acetolactate synthase"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.40.50.970:FF:000053","properties":[{"key":"EntryName","value":"Acetolactate synthase, mitochondrial"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.40.50.970","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"2"}]},{"database":"Gene3D","id":"3.40.50.1220","properties":[{"key":"EntryName","value":"TPP-binding domain"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR012846","properties":[{"key":"EntryName","value":"Acetolactate_synth_lsu"}]},{"database":"InterPro","id":"IPR039368","properties":[{"key":"EntryName","value":"AHAS_TPP"}]},{"database":"InterPro","id":"IPR029035","properties":[{"key":"EntryName","value":"DHS-like_NAD/FAD-binding_dom"}]},{"database":"InterPro","id":"IPR029061","properties":[{"key":"EntryName","value":"THDP-binding"}]},{"database":"InterPro","id":"IPR012000","properties":[{"key":"EntryName","value":"Thiamin_PyroP_enz_cen_dom"}]},{"database":"InterPro","id":"IPR012001","properties":[{"key":"EntryName","value":"Thiamin_PyroP_enz_TPP-bd_dom"}]},{"database":"InterPro","id":"IPR000399","properties":[{"key":"EntryName","value":"TPP-bd_CS"}]},{"database":"InterPro","id":"IPR045229","properties":[{"key":"EntryName","value":"TPP_enz"}]},{"database":"InterPro","id":"IPR011766","properties":[{"key":"EntryName","value":"TPP_enzyme_TPP-bd"}]},{"database":"NCBIfam","id":"TIGR00118","properties":[{"key":"EntryName","value":"acolac_lg"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR18968:SF13","properties":[{"key":"EntryName","value":"ACETOLACTATE SYNTHASE CATALYTIC SUBUNIT, MITOCHONDRIAL"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR18968","properties":[{"key":"EntryName","value":"THIAMINE PYROPHOSPHATE ENZYMES"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF02775","properties":[{"key":"EntryName","value":"TPP_enzyme_C"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00205","properties":[{"key":"EntryName","value":"TPP_enzyme_M"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF02776","properties":[{"key":"EntryName","value":"TPP_enzyme_N"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF52467","properties":[{"key":"EntryName","value":"DHS-like NAD/FAD-binding domain"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF52518","properties":[{"key":"EntryName","value":"Thiamin diphosphate-binding fold (THDP-binding)"},{"key":"MatchStatus","value":"2"}]},{"database":"PROSITE","id":"PS00187","properties":[{"key":"EntryName","value":"TPP_ENZYMES"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"EREGVTDVFAYPGGASMEIHQALTRSTTIRNVLPRHEQGGIFAAEGYARASGLPGVCIATSGPGATNLVSGLADALLDSVPVVAITGQVPRRMIGTDAFQETPIVEVTRSITKHNYLVLDVDDIPRIVREAFYLARSGRPGPVLIDIPKDIQQQLCVPKWDEPMRLPGYLSRLPKPPNDGLLEQIVRLVGESKRPVLYVGGGCLNSSDELRRFVELTGIPVASTLMGLGSYPASSDLSLQMLGMHGTVYANYAVDKADLLLAFGVRFDERVTGKLEAFASRAKIVHIDIDSAEIGKNKQPHVSVCGDIKIALQGLNKILEGRREMSNLDFSAWRAELDEQKVNHPLSFKTFGEAIPPQYAIXVLDELTGGNAIISTGVGQHQMWAAQFYKYNRPRQWLTSGGLGAMGFGLPAAIGAAVARPDAVVVDIDGDGSFIMNVQELATIRVENLPVKVLLLNNQHLGMVVQWEDRFYKANRAHTYLGNPSKEAEIFPNMLKFAEACDIPAARVTRKADLRAAIQKMLDTPGPYLLDVIVPHQEHVLPMIPAGGGFMDVITEG","length":557,"molWeight":60569,"crc64":"94887B460077649E","md5":"F2FFD993669CC06CAAC4374ABCA54091"},"extraAttributes":{"countByCommentType":{"CATALYTIC ACTIVITY":1,"COFACTOR":2,"PATHWAY":2,"SIMILARITY":1},"countByFeatureType":{"Domain":3,"Non-terminal residue":2},"uniParcId":"UPI000231E77F"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"Q6E6L3","uniProtkbId":"Q6E6L3_ERICD","entryAudit":{"firstPublicDate":"2004-08-16","lastAnnotationUpdateDate":"2026-11-04","lastSequenceUpdateDate":"2004-08-16","entryVersion":95,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Erigeron canadensis","commonName":"Canadian horseweed","synonyms":["Conyza canadensis"],"taxonId":72917,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAT45245.1"}],"lineage":["Eukaryota","Viridiplantae","Streptophyta","Embryophyta","Tracheophyta","Spermatophyta","Magnoliopsida","eudicotyledons","Gunneridae","Pentapetalae","asterids","campanulids","Asterales","Asteraceae","Asteroideae","Astereae","North American clade","Conyzinae","Erigeron"]},"proteinExistence":"2: Evidence at transcript level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00012450"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU004164"}],"value":"3-phosphoshikimate 1-carboxyvinyltransferase"},"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00012450"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU004164"}],"value":"2.5.1.19"}]},"flag":"Fragment"},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAT45245.1"}],"value":"EPSPS3"}}],"comments":[{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"3-phosphoshikimate + phosphoenolpyruvate = 5-O-(1-carboxyvinyl)-3-phosphoshikimate + phosphate","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:21256"},{"database":"ChEBI","id":"CHEBI:43474"},{"database":"ChEBI","id":"CHEBI:57701"},{"database":"ChEBI","id":"CHEBI:58702"},{"database":"ChEBI","id":"CHEBI:145989"}],"ecNumber":"2.5.1.19","evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00044633"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:21257"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00044633"}]}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004811"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU004164"}],"value":"Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 6/7"}],"commentType":"PATHWAY"},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004229"}],"value":"Plastid, chloroplast","id":"SL-0049"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00009948"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU004164"}],"value":"Belongs to the EPSP synthase family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Domain","location":{"start":{"value":18,"modifier":"EXACT"},"end":{"value":448,"modifier":"EXACT"}},"description":"Enolpyruvate transferase","evidences":[{"evidenceCode":"ECO:0000259","source":"Pfam","id":"PF00275"}]},{"type":"Non-terminal residue","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":1,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAT45245.1"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022605"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU004164"}],"id":"KW-0028","category":"Biological process","name":"Amino-acid biosynthesis"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023141"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU004164"}],"id":"KW-0057","category":"Biological process","name":"Aromatic amino acid biosynthesis"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022528"}],"id":"KW-0150","category":"Cellular component","name":"Chloroplast"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022640"}],"id":"KW-0934","category":"Cellular component","name":"Plastid"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022679"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU004164"}],"id":"KW-0808","category":"Molecular function","name":"Transferase"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022946"}],"id":"KW-0809","category":"Domain","name":"Transit peptide"}],"references":[{"referenceNumber":1,"citation":{"id":"CI-CFP19P9J8JDF","citationType":"submission","authors":["Heck G.R.","Alibhai M.","Hubmeier C.S.","Flasinski S.","Malven M.","Qi Y.","Chen Y.-C.S.","Bunkers G.J.","Sammons R.D.","Feng P.C.C.","Foadey W.T.","CaJacob C.A."],"title":"Investigations into glyphosate resistant horseweed (Conyza canadensis): EPSPS gene family.","publicationDate":"FEB-2004","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAT45245.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AY545668","properties":[{"key":"ProteinId","value":"AAT45245.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"AlphaFoldDB","id":"Q6E6L3","properties":[{"key":"Description","value":"-"}]},{"database":"UniPathway","id":"UPA00053","properties":[{"key":"RectionId","value":"UER00089"}]},{"database":"GO","id":"GO:0009507","properties":[{"key":"GoTerm","value":"C:chloroplast"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0003866","properties":[{"key":"GoTerm","value":"F:3-phosphoshikimate 1-carboxyvinyltransferase activity"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniRule"}]},{"database":"GO","id":"GO:0009073","properties":[{"key":"GoTerm","value":"P:aromatic amino acid biosynthetic process"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniRule"}]},{"database":"GO","id":"GO:0009423","properties":[{"key":"GoTerm","value":"P:chorismate biosynthetic process"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniRule"}]},{"database":"CDD","id":"cd01556","properties":[{"key":"EntryName","value":"EPSP_synthase"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.65.10.10:FF:000004","properties":[{"key":"EntryName","value":"3-phosphoshikimate 1-carboxyvinyltransferase"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.65.10.10:FF:000009","properties":[{"key":"EntryName","value":"3-phosphoshikimate 1-carboxyvinyltransferase"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.65.10.10","properties":[{"key":"EntryName","value":"Enolpyruvate transferase domain"},{"key":"MatchStatus","value":"2"}]},{"database":"HAMAP","id":"MF_00210","properties":[{"key":"EntryName","value":"EPSP_synth"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR001986","properties":[{"key":"EntryName","value":"Enolpyruvate_Tfrase_dom"}]},{"database":"InterPro","id":"IPR036968","properties":[{"key":"EntryName","value":"Enolpyruvate_Tfrase_sf"}]},{"database":"InterPro","id":"IPR006264","properties":[{"key":"EntryName","value":"EPSP_synthase"}]},{"database":"InterPro","id":"IPR023193","properties":[{"key":"EntryName","value":"EPSP_synthase_CS"}]},{"database":"InterPro","id":"IPR013792","properties":[{"key":"EntryName","value":"RNA3'P_cycl/enolpyr_Trfase_a/b"}]},{"database":"NCBIfam","id":"TIGR01356","properties":[{"key":"EntryName","value":"aroA"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR21090","properties":[{"key":"EntryName","value":"AROM/DEHYDROQUINATE SYNTHASE"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR21090:SF5","properties":[{"key":"EntryName","value":"PENTAFUNCTIONAL AROM POLYPEPTIDE"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00275","properties":[{"key":"EntryName","value":"EPSP_synthase"},{"key":"MatchStatus","value":"1"}]},{"database":"PIRSF","id":"PIRSF000505","properties":[{"key":"EntryName","value":"EPSPS"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF55205","properties":[{"key":"EntryName","value":"EPT/RTPC-like"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00104","properties":[{"key":"EntryName","value":"EPSP_SYNTHASE_1"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00885","properties":[{"key":"EntryName","value":"EPSP_SYNTHASE_2"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"ANTTKEKPSKAPEEIVLKPIQEISGTVHLPGSKSLSNRILLLAALSEGTTVVDNLLNSDDVHYMLGALRALGLNIEENAAIKRAIVEGCGGLFPVGKEAKDEIQLFLGNAGTAMRTLTAAVTAAGGNLSYVLDGVPRMRERPIGDLVTGLKQLGVNVDCSLGTNCPPVHVVGSGGLPGGKVKLSGSISSVYLTSLLMAAPLALGDVEIEIIDKLISVPYVRMTLKLMQRFGVSVEHSDTLDRFHVRGGQKYKSPGNAYVESDASSASYFLAGAAITGGTVTVEGCGTSSLQGDVKFAEVLGQMGAEVTWTENSVTVKGPPRNSSGRGHLRPVDVNMNKMPDVAMTLAVVALYADGPTAIRDVASWRVKETERMIAICTELRKLGATVEEGPDYCVTTPPEKLNVTAIDTYDDHRMAMTFSLAACADVPVTIKDPGCTRKSFPDYFEVLERYTKH","length":454,"molWeight":48265,"crc64":"E0BEE375DAD5A157","md5":"5975654E627527171D82E940F3BFF460"},"extraAttributes":{"countByCommentType":{"CATALYTIC ACTIVITY":1,"PATHWAY":1,"SUBCELLULAR LOCATION":1,"SIMILARITY":1},"countByFeatureType":{"Domain":1,"Non-terminal residue":1},"uniParcId":"UPI00003B9C38"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0A126WWC5","uniProtkbId":"A0A126WWC5_ERICD","entryAudit":{"firstPublicDate":"2016-05-11","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2016-05-11","entryVersion":22,"sequenceVersion":1},"annotationScore":1.0,"organism":{"scientificName":"Erigeron canadensis","commonName":"Canadian horseweed","synonyms":["Conyza canadensis"],"taxonId":72917,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AML76746.1"}],"lineage":["Eukaryota","Viridiplantae","Streptophyta","Embryophyta","Tracheophyta","Spermatophyta","Magnoliopsida","eudicotyledons","Gunneridae","Pentapetalae","asterids","campanulids","Asterales","Asteraceae","Asteroideae","Astereae","North American clade","Conyzinae","Erigeron"]},"proteinExistence":"2: Evidence at transcript level","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AML76746.1"}],"value":"Putative LOV domain-containing protein"}}]},"features":[{"type":"Domain","location":{"start":{"value":183,"modifier":"EXACT"},"end":{"value":229,"modifier":"EXACT"}},"description":"PAS","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50112"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022991"}],"id":"KW-0157","category":"Ligand","name":"Chromophore"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022630"}],"id":"KW-0285","category":"Ligand","name":"Flavoprotein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022643"}],"id":"KW-0288","category":"Ligand","name":"FMN"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022543"}],"id":"KW-0600","category":"Molecular function","name":"Photoreceptor protein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023170"}],"id":"KW-0675","category":"Molecular function","name":"Receptor"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022606"}],"id":"KW-0716","category":"Biological process","name":"Sensory transduction"}],"references":[{"referenceNumber":1,"citation":{"id":"26929367","citationType":"journal article","authors":["Glantz S.T.","Carpenter E.J.","Melkonian M.","Gardner K.H.","Boyden E.S.","Wong G.K.","Chow B.Y."],"citationCrossReferences":[{"database":"PubMed","id":"26929367"},{"database":"DOI","id":"10.1073/pnas.1509428113"}],"title":"Functional and topological diversity of LOV domain photoreceptors.","publicationDate":"2016","journal":"Proc. Natl. Acad. Sci. U.S.A.","firstPage":"E1442","lastPage":"E1451","volume":"113"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AML76746.1"}],"value":"DESP_2010568","type":"STRAIN"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AML76746.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"KU698635","properties":[{"key":"ProteinId","value":"AML76746.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"AlphaFoldDB","id":"A0A126WWC5","properties":[{"key":"Description","value":"-"}]},{"database":"GO","id":"GO:0005634","properties":[{"key":"GoTerm","value":"C:nucleus"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:0009637","properties":[{"key":"GoTerm","value":"P:response to blue light"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"CDD","id":"cd00130","properties":[{"key":"EntryName","value":"PAS"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.30.450.20","properties":[{"key":"EntryName","value":"PAS domain"},{"key":"MatchStatus","value":"2"}]},{"database":"InterPro","id":"IPR001610","properties":[{"key":"EntryName","value":"PAC"}]},{"database":"InterPro","id":"IPR000014","properties":[{"key":"EntryName","value":"PAS"}]},{"database":"InterPro","id":"IPR035965","properties":[{"key":"EntryName","value":"PAS-like_dom_sf"}]},{"database":"NCBIfam","id":"TIGR00229","properties":[{"key":"EntryName","value":"sensory_box"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR47429","properties":[{"key":"EntryName","value":"PROTEIN TWIN LOV 1"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR47429:SF2","properties":[{"key":"EntryName","value":"PROTEIN TWIN LOV 1"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF13426","properties":[{"key":"EntryName","value":"PAS_9"},{"key":"MatchStatus","value":"2"}]},{"database":"SMART","id":"SM00086","properties":[{"key":"EntryName","value":"PAC"},{"key":"MatchStatus","value":"2"}]},{"database":"SUPFAM","id":"SSF55785","properties":[{"key":"EntryName","value":"PYP-like sensor domain (PAS domain)"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50112","properties":[{"key":"EntryName","value":"PAS"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MFQGVGTHRRSLLDIRHAVRDETNILIPSLLNYHKNGTPFWILFRMFPVFGVQDGKLVHFVALQVPIFPPRSTTLLGYCRREVICSDTVPPRISNLSPDDGNNTELTDTTCKASELEKCGADSAMTSILSLLTHYSQLTGRLVSGKRCCSNYMNRVGVSLNTSLGRIKQSFVLVDPHKTDIPIVYASDAFLELTGYTRHEVLGRNCRFLSGQETDISIQSQITNSIQTGKSCTACILSYRKDGSSFWNALHMSPVRNASGNIAYIVEVHMEVTHDIQNLSVEIMQLSVVGAVKVAVRSSGMIASTSD","length":307,"molWeight":33917,"crc64":"6893EB0F30231900","md5":"CED79DFED6CF50F522ED4370563C89FD"},"extraAttributes":{"countByFeatureType":{"Domain":1},"uniParcId":"UPI00078D1A88"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0A126X3F5","uniProtkbId":"A0A126X3F5_ERICD","entryAudit":{"firstPublicDate":"2016-05-11","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2016-05-11","entryVersion":22,"sequenceVersion":1},"annotationScore":1.0,"organism":{"scientificName":"Erigeron canadensis","commonName":"Canadian horseweed","synonyms":["Conyza canadensis"],"taxonId":72917,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AML79221.1"}],"lineage":["Eukaryota","Viridiplantae","Streptophyta","Embryophyta","Tracheophyta","Spermatophyta","Magnoliopsida","eudicotyledons","Gunneridae","Pentapetalae","asterids","campanulids","Asterales","Asteraceae","Asteroideae","Astereae","North American clade","Conyzinae","Erigeron"]},"proteinExistence":"2: Evidence at transcript level","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AML79221.1"}],"value":"Putative LOV domain-containing protein"}}]},"features":[{"type":"Domain","location":{"start":{"value":17,"modifier":"EXACT"},"end":{"value":67,"modifier":"EXACT"}},"description":"PAS","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50112"}]},{"type":"Domain","location":{"start":{"value":244,"modifier":"EXACT"},"end":{"value":293,"modifier":"EXACT"}},"description":"PAS","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50112"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022991"}],"id":"KW-0157","category":"Ligand","name":"Chromophore"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022630"}],"id":"KW-0285","category":"Ligand","name":"Flavoprotein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022643"}],"id":"KW-0288","category":"Ligand","name":"FMN"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022543"}],"id":"KW-0600","category":"Molecular function","name":"Photoreceptor protein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023170"}],"id":"KW-0675","category":"Molecular function","name":"Receptor"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022606"}],"id":"KW-0716","category":"Biological process","name":"Sensory transduction"}],"references":[{"referenceNumber":1,"citation":{"id":"26929367","citationType":"journal article","authors":["Glantz S.T.","Carpenter E.J.","Melkonian M.","Gardner K.H.","Boyden E.S.","Wong G.K.","Chow B.Y."],"citationCrossReferences":[{"database":"PubMed","id":"26929367"},{"database":"DOI","id":"10.1073/pnas.1509428113"}],"title":"Functional and topological diversity of LOV domain photoreceptors.","publicationDate":"2016","journal":"Proc. Natl. Acad. Sci. U.S.A.","firstPage":"E1442","lastPage":"E1451","volume":"113"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AML79221.1"}],"value":"WSYE_2005178","type":"STRAIN"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AML79221.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"KU701650","properties":[{"key":"ProteinId","value":"AML79221.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"AlphaFoldDB","id":"A0A126X3F5","properties":[{"key":"Description","value":"-"}]},{"database":"GO","id":"GO:0005634","properties":[{"key":"GoTerm","value":"C:nucleus"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"CDD","id":"cd00130","properties":[{"key":"EntryName","value":"PAS"},{"key":"MatchStatus","value":"2"}]},{"database":"Gene3D","id":"3.30.450.20","properties":[{"key":"EntryName","value":"PAS domain"},{"key":"MatchStatus","value":"2"}]},{"database":"InterPro","id":"IPR000014","properties":[{"key":"EntryName","value":"PAS"}]},{"database":"InterPro","id":"IPR035965","properties":[{"key":"EntryName","value":"PAS-like_dom_sf"}]},{"database":"NCBIfam","id":"TIGR00229","properties":[{"key":"EntryName","value":"sensory_box"},{"key":"MatchStatus","value":"2"}]},{"database":"PANTHER","id":"PTHR47429","properties":[{"key":"EntryName","value":"PROTEIN TWIN LOV 1"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR47429:SF2","properties":[{"key":"EntryName","value":"PROTEIN TWIN LOV 1"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF13426","properties":[{"key":"EntryName","value":"PAS_9"},{"key":"MatchStatus","value":"2"}]},{"database":"SMART","id":"SM00091","properties":[{"key":"EntryName","value":"PAS"},{"key":"MatchStatus","value":"2"}]},{"database":"SUPFAM","id":"SSF55785","properties":[{"key":"EntryName","value":"PYP-like sensor domain (PAS domain)"},{"key":"MatchStatus","value":"2"}]},{"database":"PROSITE","id":"PS50112","properties":[{"key":"EntryName","value":"PAS"},{"key":"MatchStatus","value":"2"}]}],"sequence":{"value":"MEQLLEESINNRYSCWVREALDELPQSFAITDPEIPGHPIVFASTQLLKMFGYSRHEVIGRNISLFQGVATNRTSLLDIRHAVRDETNILIPSLLNYHKNGTPFWILFRMFPVFGVQDGKLVHFVALQVPIFPPRSTTLLGFCRREVICSDTVPTRISNLSPDDGNNTELTDTTCKASELEKCGADSAMTSILSLLTHYSQLTGRLVSGQRCCSSYMNRVGVSLNISLGRIKQSFVLVDPHKTDNPIVYASDAFLDLTGYTRHEVLGRNCRFLSGQETDVSIQSQITNSIQTGKSCTACILSYRKDGSSFWNALHMSPVRNASGNVRVLVDHLY","length":334,"molWeight":37326,"crc64":"A22B581EE6278469","md5":"C1985A87085EDAEB9636588E146FABD7"},"extraAttributes":{"countByFeatureType":{"Domain":2},"uniParcId":"UPI00078D8CC9"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0A126X475","uniProtkbId":"A0A126X475_ERICD","entryAudit":{"firstPublicDate":"2016-05-11","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2016-05-11","entryVersion":24,"sequenceVersion":1},"annotationScore":1.0,"organism":{"scientificName":"Erigeron canadensis","commonName":"Canadian horseweed","synonyms":["Conyza canadensis"],"taxonId":72917,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AML79220.1"}],"lineage":["Eukaryota","Viridiplantae","Streptophyta","Embryophyta","Tracheophyta","Spermatophyta","Magnoliopsida","eudicotyledons","Gunneridae","Pentapetalae","asterids","campanulids","Asterales","Asteraceae","Asteroideae","Astereae","North American clade","Conyzinae","Erigeron"]},"proteinExistence":"2: Evidence at transcript level","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AML79220.1"}],"value":"Putative LOV domain-containing protein"}}]},"features":[{"type":"Domain","location":{"start":{"value":17,"modifier":"EXACT"},"end":{"value":67,"modifier":"EXACT"}},"description":"PAS","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50112"}]},{"type":"Domain","location":{"start":{"value":244,"modifier":"EXACT"},"end":{"value":293,"modifier":"EXACT"}},"description":"PAS","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50112"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022991"}],"id":"KW-0157","category":"Ligand","name":"Chromophore"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022630"}],"id":"KW-0285","category":"Ligand","name":"Flavoprotein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022643"}],"id":"KW-0288","category":"Ligand","name":"FMN"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022543"}],"id":"KW-0600","category":"Molecular function","name":"Photoreceptor protein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023170"}],"id":"KW-0675","category":"Molecular function","name":"Receptor"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022606"}],"id":"KW-0716","category":"Biological process","name":"Sensory transduction"}],"references":[{"referenceNumber":1,"citation":{"id":"26929367","citationType":"journal article","authors":["Glantz S.T.","Carpenter E.J.","Melkonian M.","Gardner K.H.","Boyden E.S.","Wong G.K.","Chow B.Y."],"citationCrossReferences":[{"database":"PubMed","id":"26929367"},{"database":"DOI","id":"10.1073/pnas.1509428113"}],"title":"Functional and topological diversity of LOV domain photoreceptors.","publicationDate":"2016","journal":"Proc. Natl. Acad. Sci. U.S.A.","firstPage":"E1442","lastPage":"E1451","volume":"113"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AML77860.1"}],"value":"MHYG_2085565","type":"STRAIN"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AML79220.1"}],"value":"WSYE_2005177","type":"STRAIN"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AML79220.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"KU699995","properties":[{"key":"ProteinId","value":"AML77860.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"KU701649","properties":[{"key":"ProteinId","value":"AML79220.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"RefSeq","id":"XP_043630088.1","properties":[{"key":"NucleotideSequenceId","value":"XM_043774153.1"}]},{"database":"AlphaFoldDB","id":"A0A126X475","properties":[{"key":"Description","value":"-"}]},{"database":"GeneID","id":"122601387","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"ecad:122601387","properties":[{"key":"Description","value":"-"}]},{"database":"OrthoDB","id":"447251at2759","properties":[{"key":"Description","value":"-"}]},{"database":"GO","id":"GO:0005634","properties":[{"key":"GoTerm","value":"C:nucleus"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:0009637","properties":[{"key":"GoTerm","value":"P:response to blue light"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"CDD","id":"cd00130","properties":[{"key":"EntryName","value":"PAS"},{"key":"MatchStatus","value":"2"}]},{"database":"Gene3D","id":"3.30.450.20","properties":[{"key":"EntryName","value":"PAS domain"},{"key":"MatchStatus","value":"2"}]},{"database":"InterPro","id":"IPR001610","properties":[{"key":"EntryName","value":"PAC"}]},{"database":"InterPro","id":"IPR000014","properties":[{"key":"EntryName","value":"PAS"}]},{"database":"InterPro","id":"IPR035965","properties":[{"key":"EntryName","value":"PAS-like_dom_sf"}]},{"database":"NCBIfam","id":"TIGR00229","properties":[{"key":"EntryName","value":"sensory_box"},{"key":"MatchStatus","value":"2"}]},{"database":"PANTHER","id":"PTHR47429","properties":[{"key":"EntryName","value":"PROTEIN TWIN LOV 1"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR47429:SF2","properties":[{"key":"EntryName","value":"PROTEIN TWIN LOV 1"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF13426","properties":[{"key":"EntryName","value":"PAS_9"},{"key":"MatchStatus","value":"2"}]},{"database":"SMART","id":"SM00086","properties":[{"key":"EntryName","value":"PAC"},{"key":"MatchStatus","value":"2"}]},{"database":"SMART","id":"SM00091","properties":[{"key":"EntryName","value":"PAS"},{"key":"MatchStatus","value":"2"}]},{"database":"SUPFAM","id":"SSF55785","properties":[{"key":"EntryName","value":"PYP-like sensor domain (PAS domain)"},{"key":"MatchStatus","value":"2"}]},{"database":"PROSITE","id":"PS50112","properties":[{"key":"EntryName","value":"PAS"},{"key":"MatchStatus","value":"2"}]}],"sequence":{"value":"MEQLLEESINNRYSCWVREALDELPQSFAITDPEIPGHPIVFASTQLLKMFGYSRHEVIGRNISLFQGVATNRTSLLDIRHAVRDETNILIPSLLNYHKNGTPFWILFRMFPVFGVQDGKLVHFVALQVPIFPPRSTTLLGFCRREVICSDTVPTRISNLSPDDGNNTELTDTTCKASELEKCGADSAMTSILSLLTHYSQLTGRLVSGQRCCSSYMNRVGVSLNISLGRIKQSFVLVDPHKTDNPIVYASDAFLDLTGYTRHEVLGRNCRFLSGQETDVSIQSQITNSIQTGKSCTACILSYRKDGSSFWNALHMSPVRNASGNIAYIVEVHMEVTHDIQNLSVEIMQLSVVGAVKIAVRSSGMIASTSD","length":371,"molWeight":41155,"crc64":"94C2BFE266EE6B9A","md5":"1174C09867EA7A9B735297413F44F504"},"extraAttributes":{"countByFeatureType":{"Domain":2},"uniParcId":"UPI00078ED5A1"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"C0KL21","uniProtkbId":"C0KL21_ERICD","entryAudit":{"firstPublicDate":"2009-05-05","lastAnnotationUpdateDate":"2026-11-04","lastSequenceUpdateDate":"2009-05-05","entryVersion":35,"sequenceVersion":1},"annotationScore":1.0,"organism":{"scientificName":"Erigeron canadensis","commonName":"Canadian horseweed","synonyms":["Conyza canadensis"],"taxonId":72917,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ACM77810.1"}],"lineage":["Eukaryota","Viridiplantae","Streptophyta","Embryophyta","Tracheophyta","Spermatophyta","Magnoliopsida","eudicotyledons","Gunneridae","Pentapetalae","asterids","campanulids","Asterales","Asteraceae","Asteroideae","Astereae","North American clade","Conyzinae","Erigeron"]},"proteinExistence":"2: Evidence at transcript level","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ACM77810.1"}],"value":"Putative vacuolar H+ATPase"}}],"flag":"Fragment"},"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00006138"}],"value":"Belongs to the V-ATPase C subunit family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Transmembrane","location":{"start":{"value":6,"modifier":"EXACT"},"end":{"value":26,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Non-terminal residue","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":1,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ACM77810.1"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022781"}],"id":"KW-0375","category":"Biological process","name":"Hydrogen ion transport"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023065"}],"id":"KW-0406","category":"Biological process","name":"Ion transport"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-1133","category":"Domain","name":"Transmembrane helix"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022448"}],"id":"KW-0813","category":"Biological process","name":"Transport"}],"references":[{"referenceNumber":1,"citation":{"id":"CI-8S56L8KLSKKRS","citationType":"journal article","authors":["Jori B.","Racz I.","Szigeti Z.","Lasztity D."],"title":"Role of transporters in the paraquat resistance of horseweed (Conyza canadenesis (L.) Cronq.).","publicationDate":"2008","journal":"Pestic. Biochem. Physiol.","firstPage":"57","lastPage":"65","volume":"88"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ACM77810.1"}]},{"referenceNumber":2,"citation":{"id":"CI-F59498KTITU2H","citationType":"submission","authors":["Jori B.","Racz I.","Szigeti Z.","Lasztity D."],"publicationDate":"JAN-2009","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ACM77810.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"FJ618812","properties":[{"key":"ProteinId","value":"ACM77810.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"AlphaFoldDB","id":"C0KL21","properties":[{"key":"Description","value":"-"}]},{"database":"GO","id":"GO:0033180","properties":[{"key":"GoTerm","value":"C:proton-transporting V-type ATPase, V1 domain"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0015078","properties":[{"key":"GoTerm","value":"F:proton transmembrane transporter activity"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"InterPro","id":"IPR004907","properties":[{"key":"EntryName","value":"ATPase_V1-cplx_csu"}]},{"database":"InterPro","id":"IPR036132","properties":[{"key":"EntryName","value":"Vac_ATP_synth_c_sf"}]},{"database":"PANTHER","id":"PTHR10137","properties":[{"key":"EntryName","value":"V-TYPE PROTON ATPASE SUBUNIT C"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR10137:SF0","properties":[{"key":"EntryName","value":"V-TYPE PROTON ATPASE SUBUNIT C"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF118203","properties":[{"key":"EntryName","value":"Vacuolar ATP synthase subunit C"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"VGIFTILYIFYRLFCLFQSVVLSPSVKSEKKVRSILETLSDSSNSTFWKTDDDGNMGGLGGDADTHPYVSFTINLI","length":76,"molWeight":8457,"crc64":"1FF96B774C7AF55C","md5":"2C270AC162AAFE0DCD1BCAC31146A85D"},"extraAttributes":{"countByCommentType":{"SIMILARITY":1},"countByFeatureType":{"Transmembrane":1,"Non-terminal residue":1},"uniParcId":"UPI0001930BE9"}}]}