{"results":[{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"P80443","uniProtkbId":"OMP1_ACTEU","entryAudit":{"firstPublicDate":"2004-04-26","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2004-03-01","entryVersion":43,"sequenceVersion":1},"annotationScore":1.0,"organism":{"scientificName":"Actinobacillus equuli","taxonId":718,"evidences":[{"evidenceCode":"ECO:0000305"}],"lineage":["Bacteria","Pseudomonadati","Pseudomonadota","Gammaproteobacteria","Pasteurellales","Pasteurellaceae","Actinobacillus"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"value":"Major outer membrane protein"},"shortNames":[{"value":"MOMP"}]},"flag":"Fragment"},"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P80368"}],"value":"Structural rigidity of the outer membrane of elementary bodies and porin forming, permitting diffusion of solutes through the intracellular reticulate body membrane"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P80368"}],"value":"Disulfide bond interactions within and between MOMP molecules and other components form high molecular-weight oligomers"}],"commentType":"SUBUNIT"},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8837386"}],"value":"Cell outer membrane","id":"SL-0040"},"topology":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8837386"}],"value":"Multi-pass membrane protein","id":"SL-9909"}}]}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":21,"modifier":"OUTSIDE"}},"description":"Major outer membrane protein","featureId":"PRO_0000198024"},{"type":"Non-terminal residue","location":{"start":{"value":21,"modifier":"EXACT"},"end":{"value":21,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"8837386"}]}],"keywords":[{"id":"KW-0998","category":"Cellular component","name":"Cell outer membrane"},{"id":"KW-0903","category":"Technical term","name":"Direct protein sequencing"},{"id":"KW-1015","category":"PTM","name":"Disulfide bond"},{"id":"KW-0406","category":"Biological process","name":"Ion transport"},{"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"id":"KW-0626","category":"Molecular function","name":"Porin"},{"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"id":"KW-1134","category":"Domain","name":"Transmembrane beta strand"},{"id":"KW-0813","category":"Biological process","name":"Transport"}],"references":[{"referenceNumber":1,"citation":{"id":"8837386","citationType":"journal article","authors":["Hartmann L.","Schroeder W.","Luebke-Becker A."],"citationCrossReferences":[{"database":"PubMed","id":"8837386"},{"database":"DOI","id":"10.1016/s0934-8840(96)80101-0"}],"title":"Serological and biochemical properties of the major outer membrane protein within strains of the genus Actinobacillus.","publicationDate":"1996","journal":"Zentralbl. Bakteriol.","firstPage":"255","lastPage":"262","volume":"284"},"referencePositions":["PROTEIN SEQUENCE","SUBCELLULAR LOCATION"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8837386"}],"value":"C1 335","type":"STRAIN"}],"evidences":[{"evidenceCode":"ECO:0000305"}]}],"uniProtKBCrossReferences":[{"database":"AlphaFoldDB","id":"P80443","properties":[{"key":"Description","value":"-"}]},{"database":"STRING","id":"202947.ACEE_03780","properties":[{"key":"Description","value":"-"}]},{"database":"GO","id":"GO:0009279","properties":[{"key":"GoTerm","value":"C:cell outer membrane"},{"key":"GoEvidenceType","value":"EXP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8837386"}]}],"sequence":{"value":"VTVYDAEGTKVQLDGSIRLVM","length":21,"molWeight":2295,"crc64":"FA1F14CEAE66563B","md5":"6099802C68014321E26A6EE20425E14C"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"SUBUNIT":1,"SUBCELLULAR LOCATION":1},"countByFeatureType":{"Chain":1,"Non-terminal residue":1},"uniParcId":"UPI000023FF29"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"Q5U8V9","uniProtkbId":"Q5U8V9_ACTEU","entryAudit":{"firstPublicDate":"2004-12-07","lastAnnotationUpdateDate":"2026-11-04","lastSequenceUpdateDate":"2004-12-07","entryVersion":83,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Actinobacillus equuli","taxonId":718,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAV52047.1"}],"lineage":["Bacteria","Pseudomonadati","Pseudomonadota","Gammaproteobacteria","Pasteurellales","Pasteurellaceae","Actinobacillus"]},"proteinExistence":"3: Inferred from homology","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00012450"},{"evidenceCode":"ECO:0000256","source":"NCBIfam","id":"TIGR01356"}],"value":"3-phosphoshikimate 1-carboxyvinyltransferase"},"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00012450"},{"evidenceCode":"ECO:0000256","source":"NCBIfam","id":"TIGR01356"}],"value":"2.5.1.19"}]},"flag":"Fragment"},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAV52047.1"}],"value":"aroA"}}],"comments":[{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"3-phosphoshikimate + phosphoenolpyruvate = 5-O-(1-carboxyvinyl)-3-phosphoshikimate + phosphate","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:21256"},{"database":"ChEBI","id":"CHEBI:43474"},{"database":"ChEBI","id":"CHEBI:57701"},{"database":"ChEBI","id":"CHEBI:58702"},{"database":"ChEBI","id":"CHEBI:145989"}],"ecNumber":"2.5.1.19","evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00044633"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:21257"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00044633"}]}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004811"}],"value":"Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 6/7"}],"commentType":"PATHWAY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00009948"}],"value":"Belongs to the EPSP synthase family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Domain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":297,"modifier":"EXACT"}},"description":"Enolpyruvate transferase","evidences":[{"evidenceCode":"ECO:0000259","source":"Pfam","id":"PF00275"}]},{"type":"Non-terminal residue","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":1,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAV52047.1"}]},{"type":"Non-terminal residue","location":{"start":{"value":297,"modifier":"EXACT"},"end":{"value":297,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAV52047.1"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022605"}],"id":"KW-0028","category":"Biological process","name":"Amino-acid biosynthesis"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023141"}],"id":"KW-0057","category":"Biological process","name":"Aromatic amino acid biosynthesis"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022679"}],"id":"KW-0808","category":"Molecular function","name":"Transferase"}],"references":[{"referenceNumber":1,"citation":{"id":"CI-621C82NQH3P8D","citationType":"submission","authors":["del Rio M.L.","Rodriguez-Barbosa J.I.","Gutierrez-Martin C.B.","Navas J.","Rodriguez-Ferri E.F."],"publicationDate":"OCT-2004","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAV52047.1"}],"value":"NCTC 8529","type":"STRAIN"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAV52047.1"}]},{"referenceNumber":2,"citation":{"id":"15936788","citationType":"journal article","authors":["del Rio M.L.","Martin C.B.","Navas J.","Gutierrez-Muniz B.","Rodriguez-Barbosa J.I.","Rodriguez Ferri E.F."],"citationCrossReferences":[{"database":"PubMed","id":"15936788"},{"database":"DOI","id":"10.1016/j.rvsc.2005.03.004"}],"title":"aroA gene PCR-RFLP diversity patterns in Haemophilus parasuis and Actinobacillus species.","publicationDate":"2006","journal":"Res. Vet. Sci.","firstPage":"55","lastPage":"61","volume":"80"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAV52047.1"}],"value":"NCTC 8529","type":"STRAIN"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAV52047.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AY775557","properties":[{"key":"ProteinId","value":"AAV52047.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"AlphaFoldDB","id":"Q5U8V9","properties":[{"key":"Description","value":"-"}]},{"database":"UniPathway","id":"UPA00053","properties":[{"key":"RectionId","value":"UER00089"}]},{"database":"GO","id":"GO:0003866","properties":[{"key":"GoTerm","value":"F:3-phosphoshikimate 1-carboxyvinyltransferase activity"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniRule"}]},{"database":"GO","id":"GO:0009073","properties":[{"key":"GoTerm","value":"P:aromatic amino acid biosynthetic process"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0009423","properties":[{"key":"GoTerm","value":"P:chorismate biosynthetic process"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniRule"}]},{"database":"CDD","id":"cd01556","properties":[{"key":"EntryName","value":"EPSP_synthase"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.65.10.10:FF:000004","properties":[{"key":"EntryName","value":"3-phosphoshikimate 1-carboxyvinyltransferase"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.65.10.10","properties":[{"key":"EntryName","value":"Enolpyruvate transferase domain"},{"key":"MatchStatus","value":"2"}]},{"database":"InterPro","id":"IPR001986","properties":[{"key":"EntryName","value":"Enolpyruvate_Tfrase_dom"}]},{"database":"InterPro","id":"IPR036968","properties":[{"key":"EntryName","value":"Enolpyruvate_Tfrase_sf"}]},{"database":"InterPro","id":"IPR006264","properties":[{"key":"EntryName","value":"EPSP_synthase"}]},{"database":"InterPro","id":"IPR023193","properties":[{"key":"EntryName","value":"EPSP_synthase_CS"}]},{"database":"InterPro","id":"IPR013792","properties":[{"key":"EntryName","value":"RNA3'P_cycl/enolpyr_Trfase_a/b"}]},{"database":"NCBIfam","id":"TIGR01356","properties":[{"key":"EntryName","value":"aroA"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR21090","properties":[{"key":"EntryName","value":"AROM/DEHYDROQUINATE SYNTHASE"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR21090:SF5","properties":[{"key":"EntryName","value":"PENTAFUNCTIONAL AROM POLYPEPTIDE"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00275","properties":[{"key":"EntryName","value":"EPSP_synthase"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF55205","properties":[{"key":"EntryName","value":"EPT/RTPC-like"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00104","properties":[{"key":"EntryName","value":"EPSP_SYNTHASE_1"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"LNALKALGVNYSLSEDKTVCTVEGIGGAFNWQNGLSLFLGNAGTAMRPLTAALCLKGASEAEVILTGEPRMKERPIKHLVDALRQVGASVQYLENEGYPPLAIRNSGLKGGKVQIDGSISSQFLTALLMAAPLAEGDMEIEIIGELVSKPYIDITLAMMKDFGVNVENQNYQTFVVKGNQSYISPEKYLVEGDASSASYFLAAGAIKGKVKVTGIGKNSIQGDRLFANVLEAMGAKITWGDDFIQAEQGELKGVDMDMNHIPDAAMTIATTALFAEGETIIRNIYNWRVKETDRLAA","length":297,"molWeight":31929,"crc64":"56A924B2E42DAA1B","md5":"63466298CA698FDDE8FCAB2BE000A51C"},"extraAttributes":{"countByCommentType":{"CATALYTIC ACTIVITY":1,"PATHWAY":1,"SIMILARITY":1},"countByFeatureType":{"Domain":1,"Non-terminal residue":2},"uniParcId":"UPI0000465748"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"Q8KI30","uniProtkbId":"Q8KI30_ACTEU","entryAudit":{"firstPublicDate":"2002-10-01","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2002-10-01","entryVersion":88,"sequenceVersion":1},"annotationScore":1.0,"organism":{"scientificName":"Actinobacillus equuli","taxonId":718,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"CAD27202.1"}],"lineage":["Bacteria","Pseudomonadati","Pseudomonadota","Gammaproteobacteria","Pasteurellales","Pasteurellaceae","Actinobacillus"]},"proteinExistence":"3: Inferred from homology","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"CAD27202.1"}],"value":"Translation initiation factor IF2"}}],"flag":"Fragment"},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"CAD27202.1"}],"value":"infB"}}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00007733"}],"value":"Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily"}],"commentType":"SIMILARITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU01059"}],"value":"Lacks conserved residue(s) required for the propagation of feature annotation"}],"commentType":"CAUTION"}],"features":[{"type":"Domain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":135,"modifier":"EXACT"}},"description":"Tr-type G","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS51722"}]},{"type":"Non-terminal residue","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":1,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"CAD27202.1"}]},{"type":"Non-terminal residue","location":{"start":{"value":142,"modifier":"EXACT"},"end":{"value":142,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"CAD27202.1"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023134"}],"id":"KW-0342","category":"Ligand","name":"GTP-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022540"},{"evidenceCode":"ECO:0000313","source":"EMBL","id":"CAD27202.1"}],"id":"KW-0396","category":"Molecular function","name":"Initiation factor"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022741"}],"id":"KW-0547","category":"Ligand","name":"Nucleotide-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022917"}],"id":"KW-0648","category":"Biological process","name":"Protein biosynthesis"}],"references":[{"referenceNumber":1,"citation":{"id":"15143001","citationType":"journal article","authors":["Norskov-Lauritsen N.","Christensen H.","Okkels H.","Kilian M.","Bruun B."],"citationCrossReferences":[{"database":"PubMed","id":"15143001"},{"database":"DOI","id":"10.1099/ijs.0.02785-0"}],"title":"Delineation of the genus Actinobacillus by comparison of partial infB sequences.","publicationDate":"2004","journal":"Int. J. Syst. Evol. Microbiol.","firstPage":"635","lastPage":"644","volume":"54"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"CAD27207.1"}],"value":"CCUG 19799","type":"STRAIN"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"CAD27206.1"}],"value":"F119","type":"STRAIN"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"CAD27375.1"}],"value":"F490","type":"STRAIN"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"CAD27204.1"}],"value":"F92","type":"STRAIN"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"CAD27205.1"}],"value":"I5445/4","type":"STRAIN"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"CAD27202.1"}],"value":"P157 T","type":"STRAIN"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"CAD27376.1"}],"value":"P1577","type":"STRAIN"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"CAD27203.1"}],"value":"P238","type":"STRAIN"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"CAD27372.1"}],"value":"P240","type":"STRAIN"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"CAD27373.1"}],"value":"P242","type":"STRAIN"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"CAD27374.1"}],"value":"P861","type":"STRAIN"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"CAD27210.1"}],"value":"T355/87","type":"STRAIN"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"CAD27202.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AJ438106","properties":[{"key":"ProteinId","value":"CAD27202.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AJ438107","properties":[{"key":"ProteinId","value":"CAD27203.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AJ438108","properties":[{"key":"ProteinId","value":"CAD27204.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AJ438109","properties":[{"key":"ProteinId","value":"CAD27205.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AJ438110","properties":[{"key":"ProteinId","value":"CAD27206.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AJ438111","properties":[{"key":"ProteinId","value":"CAD27207.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AJ438114","properties":[{"key":"ProteinId","value":"CAD27210.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AJ438445","properties":[{"key":"ProteinId","value":"CAD27372.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AJ438446","properties":[{"key":"ProteinId","value":"CAD27373.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AJ438447","properties":[{"key":"ProteinId","value":"CAD27374.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AJ438448","properties":[{"key":"ProteinId","value":"CAD27375.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AJ438449","properties":[{"key":"ProteinId","value":"CAD27376.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"AlphaFoldDB","id":"Q8KI30","properties":[{"key":"Description","value":"-"}]},{"database":"GO","id":"GO:0005829","properties":[{"key":"GoTerm","value":"C:cytosol"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:0005525","properties":[{"key":"GoTerm","value":"F:GTP binding"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0003924","properties":[{"key":"GoTerm","value":"F:GTPase activity"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0003743","properties":[{"key":"GoTerm","value":"F:translation initiation factor activity"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"CDD","id":"cd01887","properties":[{"key":"EntryName","value":"IF2_eIF5B"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.40.50.300:FF:000019","properties":[{"key":"EntryName","value":"Translation initiation factor IF-2"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.40.50.300","properties":[{"key":"EntryName","value":"P-loop containing nucleotide triphosphate hydrolases"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR027417","properties":[{"key":"EntryName","value":"P-loop_NTPase"}]},{"database":"InterPro","id":"IPR005225","properties":[{"key":"EntryName","value":"Small_GTP-bd"}]},{"database":"InterPro","id":"IPR000795","properties":[{"key":"EntryName","value":"T_Tr_GTP-bd_dom"}]},{"database":"InterPro","id":"IPR015760","properties":[{"key":"EntryName","value":"TIF_IF2"}]},{"database":"NCBIfam","id":"TIGR00231","properties":[{"key":"EntryName","value":"small_GTP"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR43381:SF5","properties":[{"key":"EntryName","value":"TR-TYPE G DOMAIN-CONTAINING PROTEIN"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR43381","properties":[{"key":"EntryName","value":"TRANSLATION INITIATION FACTOR IF-2-RELATED"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00009","properties":[{"key":"EntryName","value":"GTP_EFTU"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR00315","properties":[{"key":"EntryName","value":"ELONGATNFCT"}]},{"database":"SUPFAM","id":"SSF52540","properties":[{"key":"EntryName","value":"P-loop containing nucleoside triphosphate hydrolases"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS51722","properties":[{"key":"EntryName","value":"G_TR_2"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"TQHIGAYHVETDDGKMITFLDTPGHAAFTSMRARGAKATDIVVLVVAADDGVMPQTIEAIQHAKAAGAPIVVAVNKIDKPEANPDRVEQELLQHEVISEKFGGDVQFVPVSAKKGLGIDELLEAILLQSEVLELTAVKEGMA","length":142,"molWeight":15108,"crc64":"37572EB28724A32C","md5":"57E3836E3679DA74F4EB84BA6A4C1A9B"},"extraAttributes":{"countByCommentType":{"SIMILARITY":1,"CAUTION":1},"countByFeatureType":{"Domain":1,"Non-terminal residue":2},"uniParcId":"UPI00000B27B6"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"Q8KWZ6","uniProtkbId":"Q8KWZ6_ACTEU","entryAudit":{"firstPublicDate":"2002-10-01","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2002-10-01","entryVersion":72,"sequenceVersion":1},"annotationScore":1.0,"organism":{"scientificName":"Actinobacillus equuli","taxonId":718,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAM45569.1"}],"lineage":["Bacteria","Pseudomonadati","Pseudomonadota","Gammaproteobacteria","Pasteurellales","Pasteurellaceae","Actinobacillus"]},"proteinExistence":"3: Inferred from homology","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAM45569.1"}],"value":"AqxA"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAM45569.1"}],"value":"aqxA"}}],"comments":[{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004598"}],"value":"Host cell membrane","id":"SL-0375"},"topology":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004598"}],"value":"Multi-pass membrane protein","id":"SL-9909"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004613"}],"value":"Secreted","id":"SL-0243"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00005918"}],"value":"Belongs to the RTX prokaryotic toxin (TC 1.C.11) family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Domain","location":{"start":{"value":299,"modifier":"EXACT"},"end":{"value":602,"modifier":"EXACT"}},"description":"RTX pore-forming","evidences":[{"evidenceCode":"ECO:0000259","source":"Pfam","id":"PF02382"}]},{"type":"Domain","location":{"start":{"value":827,"modifier":"EXACT"},"end":{"value":954,"modifier":"EXACT"}},"description":"RTX C-terminal","evidences":[{"evidenceCode":"ECO:0000259","source":"Pfam","id":"PF08339"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022837"}],"id":"KW-0106","category":"Ligand","name":"Calcium"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022852"}],"id":"KW-0204","category":"Biological process","name":"Cytolysis"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022511"}],"id":"KW-1032","category":"Cellular component","name":"Host cell membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022870"}],"id":"KW-1043","category":"Cellular component","name":"Host membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023288"}],"id":"KW-0449","category":"PTM","name":"Lipoprotein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023136"}],"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022737"}],"id":"KW-0677","category":"Domain","name":"Repeat"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022525"}],"id":"KW-0964","category":"Cellular component","name":"Secreted"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022656"}],"id":"KW-0800","category":"Molecular function","name":"Toxin"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022692"}],"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022989"}],"id":"KW-1133","category":"Domain","name":"Transmembrane helix"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023026"}],"id":"KW-0843","category":"Biological process","name":"Virulence"}],"references":[{"referenceNumber":1,"citation":{"id":"12034544","citationType":"journal article","authors":["Berthoud H.","Frey J.","Kuhnert P."],"citationCrossReferences":[{"database":"PubMed","id":"12034544"},{"database":"DOI","id":"10.1016/S0378-1135(02)00048-2"}],"title":"Characterization of Aqx and its operon: the hemolytic RTX determinant of Actinobacillus equuli.","publicationDate":"2002","journal":"Vet. Microbiol.","firstPage":"159","lastPage":"174","volume":"87"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAM45569.1"}],"value":"90-570","type":"STRAIN"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAM45569.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AF381185","properties":[{"key":"ProteinId","value":"AAM45569.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"AlphaFoldDB","id":"Q8KWZ6","properties":[{"key":"Description","value":"-"}]},{"database":"GO","id":"GO:0005576","properties":[{"key":"GoTerm","value":"C:extracellular region"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0020002","properties":[{"key":"GoTerm","value":"C:host cell plasma membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0005509","properties":[{"key":"GoTerm","value":"F:calcium ion binding"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0015267","properties":[{"key":"GoTerm","value":"F:channel activity"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"Gene3D","id":"2.150.10.10","properties":[{"key":"EntryName","value":"Serralysin-like metalloprotease, C-terminal"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR018511","properties":[{"key":"EntryName","value":"Hemolysin-typ_Ca-bd_CS"}]},{"database":"InterPro","id":"IPR001343","properties":[{"key":"EntryName","value":"Hemolysn_Ca-bd"}]},{"database":"InterPro","id":"IPR013550","properties":[{"key":"EntryName","value":"RTX_C"}]},{"database":"InterPro","id":"IPR018504","properties":[{"key":"EntryName","value":"RTX_pore_form"}]},{"database":"InterPro","id":"IPR050557","properties":[{"key":"EntryName","value":"RTX_toxin/Mannuronan_C5-epim"}]},{"database":"InterPro","id":"IPR003995","properties":[{"key":"EntryName","value":"RTX_toxin_determinant-A"}]},{"database":"InterPro","id":"IPR011049","properties":[{"key":"EntryName","value":"Serralysin-like_metalloprot_C"}]},{"database":"NCBIfam","id":"NF033943","properties":[{"key":"EntryName","value":"RTX_toxin"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR38340","properties":[{"key":"EntryName","value":"S-LAYER PROTEIN"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR38340:SF1","properties":[{"key":"EntryName","value":"S-LAYER PROTEIN"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00353","properties":[{"key":"EntryName","value":"HemolysinCabind"},{"key":"MatchStatus","value":"2"}]},{"database":"Pfam","id":"PF02382","properties":[{"key":"EntryName","value":"RTX"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF08339","properties":[{"key":"EntryName","value":"RTX_C"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR00313","properties":[{"key":"EntryName","value":"CABNDNGRPT"}]},{"database":"PRINTS","id":"PR01488","properties":[{"key":"EntryName","value":"RTXTOXINA"}]},{"database":"SUPFAM","id":"SSF51120","properties":[{"key":"EntryName","value":"beta-Roll"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00330","properties":[{"key":"EntryName","value":"HEMOLYSIN_CALCIUM"},{"key":"MatchStatus","value":"3"}]}],"sequence":{"value":"MSKVANVLSQVPKSFGNLNLQFQQGAGKIKSGVQKGYQSSKQHLSQAGAATKNYANKLILYIPKEYDATAGNGLKGLLDAAEALGIEVQREEKDGVATAYSAFGVGEQFIGLTERGLTLFLPQLDNFLKKHPKFSKSIGDSSEKVLSNVGNAKLILSGIQSVLGTTLAGIELDNLIKEGGSKTELAQAGINLVNELVGNIAKGAETIQAFSDQLAHLGSYIQNTKGLGGLGNKLQNISGSALNKAGLGFDIVSSLLSGVSAGFALADPNASTGKKIAAGFELSNQVIGGITKAVSGYILAQRIASGLSTTGPAIGLIASSISLAISPLAFLNVADRFKHANEINKFAERFKKFGYEGDSLLADFHHESGAIDASITTINTALGAISAGVTAAGAASLVGAPVTLLVGGITGLISAILDLSKQAMFEHVATKLSGKIEAWEKKYGMNYFEKGYDARHAAFLEDNFAFFESLTKELRAERVISITQQQWDAQIGDLAGITRRGDKIQSGKAYVDVFKESKEDRNYDNIVTFDPTEGIIDISKTTSKTQHLLFLNPLLTPGKENREREKKGKYEYVTKLIVDRKTKWQVTDGEASSTLDFTNVLQFIAVDTDRAGNVTESLEAKIEAKLGKGDDTVFVGWGSTDIDGSEGYDRAAYNRLDGEAHIYGLNIDAQQETVAGSYTVNRTIGRGAAKHEVIKVHQATAGKRVDKIEYRQGESRFHNELKVVDKLVNVEEIIGTKNQDIFKGSKFNDTFFGGDEKDIIYGNAGNDRLFGGNGNDEIDGGDGNDFIDGGKGNDSLTGGYGNDIYVIHKEDGQDFITELGGDDRLVFTDTELSRLTFKRDKKVLIIEDSAHNNQVRISDWFFKDQATLNKEYHAQSALDKDYRIEEIIDKNGTRITADQIDTILNGKSEGVIEVSQLVKISDDYKAKVAADNAHLSEIAEALGKIASSSASFSAVTGGAMGSANAFAAVSENALNNKIVTLFSSYAA","length":987,"molWeight":105872,"crc64":"35440030AB522E53","md5":"140BEDB8C9210EACDA3AF252E882BF54"},"extraAttributes":{"countByCommentType":{"SUBCELLULAR LOCATION":1,"SIMILARITY":1},"countByFeatureType":{"Domain":2},"uniParcId":"UPI00000AFC5F"}}]}