{"results":[{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"E9N6B0","uniProtkbId":"E9N6B0_9FUNG","entryAudit":{"firstPublicDate":"2011-04-05","lastAnnotationUpdateDate":"2026-11-04","lastSequenceUpdateDate":"2011-04-05","entryVersion":39,"sequenceVersion":1},"annotationScore":1.0,"organism":{"scientificName":"Mucor fuscus","taxonId":708069,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ADX21038.1"}],"lineage":["Eukaryota","Fungi","Fungi incertae sedis","Mucoromycota","Mucoromycotina","Mucoromycetes","Mucorales","Mucorineae","Mucoraceae","Mucor"]},"proteinExistence":"2: Evidence at transcript level","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ADX21038.1"}],"value":"Delta-6-desaturase"}}],"flag":"Fragment"},"comments":[{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004141"}],"value":"Membrane","id":"SL-0162"},"topology":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004141"}],"value":"Multi-pass membrane protein","id":"SL-9909"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00009295"}],"value":"Belongs to the fatty acid desaturase type 1 family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Transmembrane","location":{"start":{"value":80,"modifier":"EXACT"},"end":{"value":103,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":109,"modifier":"EXACT"},"end":{"value":130,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":225,"modifier":"EXACT"},"end":{"value":247,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":259,"modifier":"EXACT"},"end":{"value":280,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":286,"modifier":"EXACT"},"end":{"value":307,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Domain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":42,"modifier":"EXACT"}},"description":"Cytochrome b5 heme-binding","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50255"}]},{"type":"Binding site","location":{"start":{"value":2,"modifier":"EXACT"},"end":{"value":2,"modifier":"EXACT"}},"description":"axial binding residue","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:60344"},{"database":"ChEBI","id":"CHEBI:18248"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00279"}],"ligand":{"name":"heme b","id":"ChEBI:CHEBI:60344"},"ligandPart":{"name":"Fe","id":"ChEBI:CHEBI:18248"}},{"type":"Binding site","location":{"start":{"value":25,"modifier":"EXACT"},"end":{"value":25,"modifier":"EXACT"}},"description":"axial binding residue","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:60344"},{"database":"ChEBI","id":"CHEBI:18248"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00279"}],"ligand":{"name":"heme b","id":"ChEBI:CHEBI:60344"},"ligandPart":{"name":"Fe","id":"ChEBI:CHEBI:18248"}},{"type":"Non-terminal residue","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":1,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ADX21038.1"}]},{"type":"Non-terminal residue","location":{"start":{"value":314,"modifier":"EXACT"},"end":{"value":314,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ADX21038.1"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00279"}],"id":"KW-0349","category":"Ligand","name":"Heme"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00279"}],"id":"KW-0408","category":"Ligand","name":"Iron"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023098"}],"id":"KW-0443","category":"Biological process","name":"Lipid metabolism"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023136"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00279"}],"id":"KW-0479","category":"Ligand","name":"Metal-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023002"}],"id":"KW-0560","category":"Molecular function","name":"Oxidoreductase"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022692"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022989"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-1133","category":"Domain","name":"Transmembrane helix"}],"references":[{"referenceNumber":1,"citation":{"id":"CI-5INSUV2HNNOJC","citationType":"submission","authors":["Klempova T.","Mihalik D.","Certik M.","Kraic J."],"publicationDate":"AUG-2010","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ADX21038.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"HQ437170","properties":[{"key":"ProteinId","value":"ADX21038.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"AlphaFoldDB","id":"E9N6B0","properties":[{"key":"Description","value":"-"}]},{"database":"GO","id":"GO:0016020","properties":[{"key":"GoTerm","value":"C:membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0016717","properties":[{"key":"GoTerm","value":"F:oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:0006629","properties":[{"key":"GoTerm","value":"P:lipid metabolic process"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"CDD","id":"cd03506","properties":[{"key":"EntryName","value":"Delta6-FADS-like"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.10.120.10","properties":[{"key":"EntryName","value":"Cytochrome b5-like heme/steroid binding domain"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR001199","properties":[{"key":"EntryName","value":"Cyt_B5-like_heme/steroid-bd"}]},{"database":"InterPro","id":"IPR036400","properties":[{"key":"EntryName","value":"Cyt_B5-like_heme/steroid_sf"}]},{"database":"InterPro","id":"IPR005804","properties":[{"key":"EntryName","value":"FA_desaturase_dom"}]},{"database":"InterPro","id":"IPR012171","properties":[{"key":"EntryName","value":"Fatty_acid_desaturase"}]},{"database":"PANTHER","id":"PTHR19353:SF88","properties":[{"key":"EntryName","value":"DELTA(5) FATTY ACID DESATURASE FAT-4"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR19353","properties":[{"key":"EntryName","value":"FATTY ACID DESATURASE 2"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00173","properties":[{"key":"EntryName","value":"Cyt-b5"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00487","properties":[{"key":"EntryName","value":"FA_desaturase"},{"key":"MatchStatus","value":"1"}]},{"database":"PIRSF","id":"PIRSF015921","properties":[{"key":"EntryName","value":"FA_sphinglp_des"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF55856","properties":[{"key":"EntryName","value":"Cytochrome b5-like heme/steroid binding domain"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50255","properties":[{"key":"EntryName","value":"CYTOCHROME_B5_2"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"DHPGGADVLLTHVGKDASDVFRAMHPDSAYEVLANYYAGDLESDTKPVDKETENSAKFATEMRDLRDKLRKEGYFHSSKLFYAYKVLSTLGLCGAGLALLYAYGRTSTLAVVASAFIIGIFWQQCGWLAHDFGHHQCFEDRSFNDVLVIFLGNFCQGFSLSWWKNKHNTHHASTDVHGQDPDIDTAPVLLWDEYASAAYYGSLDEEPTMLSRFIAESVLPYQTRYYFFVLGFARFSWALQSFIYSFNKGAINKSAKPNLYERACLISHWVTFTYCTIAWNSSFYNMVLFFLVSQATTGYTLALVFALNHNGMPV","length":314,"molWeight":35522,"crc64":"5E625D284DD66159","md5":"B490F14CAD36FE0456FE8DBA1F57C47A"},"extraAttributes":{"countByCommentType":{"SUBCELLULAR LOCATION":1,"SIMILARITY":1},"countByFeatureType":{"Transmembrane":5,"Domain":1,"Binding site":2,"Non-terminal residue":2},"uniParcId":"UPI0001F991F6"}}]}