{"results":[{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"Q9X5V1","uniProtkbId":"AHPD_STRVD","entryAudit":{"firstPublicDate":"2009-01-20","lastAnnotationUpdateDate":"2026-11-04","lastSequenceUpdateDate":"1999-11-01","entryVersion":71,"sequenceVersion":1},"annotationScore":3.0,"organism":{"scientificName":"Streptomyces viridosporus","taxonId":67581,"lineage":["Bacteria","Bacillati","Actinomycetota","Actinomycetes","Kitasatosporales","Streptomycetaceae","Streptomyces"]},"proteinExistence":"3: Inferred from homology","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000255","source":"HAMAP-Rule","id":"MF_01676"}],"value":"Alkyl hydroperoxide reductase AhpD"},"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000255","source":"HAMAP-Rule","id":"MF_01676"}],"value":"1.11.1.28"}]},"alternativeNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000255","source":"HAMAP-Rule","id":"MF_01676"}],"value":"Alkylhydroperoxidase AhpD"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000255","source":"HAMAP-Rule","id":"MF_01676"}],"value":"ahpD"},"synonyms":[{"value":"ahpX"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000255","source":"HAMAP-Rule","id":"MF_01676"}],"value":"Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity"}],"commentType":"FUNCTION"},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"N(6)-[(R)-dihydrolipoyl]-L-lysyl-[lipoyl-carrier protein] + a hydroperoxide = N(6)-[(R)-lipoyl]-L-lysyl-[lipoyl-carrier protein] + an alcohol + H2O","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:62636"},{"database":"Rhea","id":"RHEA-COMP:10502"},{"database":"Rhea","id":"RHEA-COMP:16355"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:30879"},{"database":"ChEBI","id":"CHEBI:35924"},{"database":"ChEBI","id":"CHEBI:83099"},{"database":"ChEBI","id":"CHEBI:83100"}],"ecNumber":"1.11.1.28","evidences":[{"evidenceCode":"ECO:0000255","source":"HAMAP-Rule","id":"MF_01676"}]}},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000255","source":"HAMAP-Rule","id":"MF_01676"}],"value":"Homotrimer"}],"commentType":"SUBUNIT"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000255","source":"HAMAP-Rule","id":"MF_01676"}],"value":"Belongs to the AhpD family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":174,"modifier":"EXACT"}},"description":"Alkyl hydroperoxide reductase AhpD","featureId":"PRO_0000359511"},{"type":"Active site","location":{"start":{"value":131,"modifier":"EXACT"},"end":{"value":131,"modifier":"EXACT"}},"description":"Proton donor","evidences":[{"evidenceCode":"ECO:0000255","source":"HAMAP-Rule","id":"MF_01676"}]},{"type":"Active site","location":{"start":{"value":134,"modifier":"EXACT"},"end":{"value":134,"modifier":"EXACT"}},"description":"Cysteine sulfenic acid (-SOH) intermediate","evidences":[{"evidenceCode":"ECO:0000255","source":"HAMAP-Rule","id":"MF_01676"}]},{"type":"Disulfide bond","location":{"start":{"value":131,"modifier":"EXACT"},"end":{"value":134,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000250"}]},{"type":"Disulfide bond","location":{"start":{"value":134,"modifier":"EXACT"},"end":{"value":134,"modifier":"EXACT"}},"description":"Interchain (with AhpC); in linked form","evidences":[{"evidenceCode":"ECO:0000255","source":"HAMAP-Rule","id":"MF_01676"}]}],"keywords":[{"id":"KW-0049","category":"Molecular function","name":"Antioxidant"},{"id":"KW-1015","category":"PTM","name":"Disulfide bond"},{"id":"KW-0560","category":"Molecular function","name":"Oxidoreductase"},{"id":"KW-0575","category":"Molecular function","name":"Peroxidase"},{"id":"KW-0676","category":"Domain","name":"Redox-active center"}],"references":[{"referenceNumber":1,"citation":{"id":"10902909","citationType":"journal article","authors":["Ramachandran S.","Magnuson T.S.","Crawford D.L."],"citationCrossReferences":[{"database":"PubMed","id":"10902909"},{"database":"DOI","id":"10.3109/10425170009033969"}],"title":"Isolation and analysis of three peroxide sensor regulatory gene homologs ahpC, ahpX and oxyR in Streptomyces viridosporus T7A -- a lignocellulose degrading actinomycete.","publicationDate":"2000","journal":"DNA Seq.","firstPage":"51","lastPage":"60","volume":"11"},"referencePositions":["NUCLEOTIDE SEQUENCE [GENOMIC DNA]"],"referenceComments":[{"value":"T7A","type":"STRAIN"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AF127576","properties":[{"key":"ProteinId","value":"AAD33341.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"AlphaFoldDB","id":"Q9X5V1","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"Q9X5V1","properties":[{"key":"Description","value":"-"}]},{"database":"PeroxiBase","id":"4602","properties":[{"key":"EntryName","value":"SvAhpD"}]},{"database":"OMA","id":"ACAYNEG","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"GO","id":"GO:0015036","properties":[{"key":"GoTerm","value":"F:disulfide oxidoreductase activity"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:0160319","properties":[{"key":"GoTerm","value":"F:lipoyl-dependent peroxiredoxin activity"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-EC"}]},{"database":"GO","id":"GO:0051920","properties":[{"key":"GoTerm","value":"F:peroxiredoxin activity"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0045454","properties":[{"key":"GoTerm","value":"P:cell redox homeostasis"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:0006979","properties":[{"key":"GoTerm","value":"P:response to oxidative stress"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"Gene3D","id":"1.20.1290.10","properties":[{"key":"EntryName","value":"AhpD-like"},{"key":"MatchStatus","value":"1"}]},{"database":"HAMAP","id":"MF_01676","properties":[{"key":"EntryName","value":"AhpD"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR004674","properties":[{"key":"EntryName","value":"AhpD"}]},{"database":"InterPro","id":"IPR029032","properties":[{"key":"EntryName","value":"AhpD-like"}]},{"database":"InterPro","id":"IPR003779","properties":[{"key":"EntryName","value":"AhpD/CMD-like"}]},{"database":"InterPro","id":"IPR004675","properties":[{"key":"EntryName","value":"AhpD_core"}]},{"database":"NCBIfam","id":"TIGR00777","properties":[{"key":"EntryName","value":"ahpD"},{"key":"MatchStatus","value":"1"}]},{"database":"NCBIfam","id":"TIGR00778","properties":[{"key":"EntryName","value":"ahpD_dom"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR33930","properties":[{"key":"EntryName","value":"ALKYL HYDROPEROXIDE REDUCTASE AHPD"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR33930:SF7","properties":[{"key":"EntryName","value":"ALKYL HYDROPEROXIDE REDUCTASE AHPD"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF02627","properties":[{"key":"EntryName","value":"CMD"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF69118","properties":[{"key":"EntryName","value":"AhpD-like"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MSLDSLKSRIPDYAKDLKLNLGSVIGNSGLPAQQLWGTVLSTAIASRSAIVLRELEPEAKANLSPEAYTAAKAAAAVMAMNNVFYRTRHLLSDHEYGNLRAGLRMNVIGNPGVDKVDFEFWSFAVSAINGCGMCLDSTKQVLRKAGVERRSSRRRSDCRGTQAVAATLDAEAFS","length":174,"molWeight":18808,"crc64":"EA39EBEECDB18AE7","md5":"691151FA6B7C6290A50220CB5AF95E64"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"CATALYTIC ACTIVITY":1,"SUBUNIT":1,"SIMILARITY":1},"countByFeatureType":{"Chain":1,"Active site":2,"Disulfide bond":2},"uniParcId":"UPI00000AF2D7"}},{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"Q9X5P2","uniProtkbId":"OXYR_STRVD","entryAudit":{"firstPublicDate":"2000-05-30","lastAnnotationUpdateDate":"2026-11-04","lastSequenceUpdateDate":"1999-11-01","entryVersion":75,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Streptomyces viridosporus","taxonId":67581,"lineage":["Bacteria","Bacillati","Actinomycetota","Actinomycetes","Kitasatosporales","Streptomycetaceae","Streptomyces"]},"proteinExistence":"2: Evidence at transcript level","proteinDescription":{"recommendedName":{"fullName":{"value":"Probable hydrogen peroxide-inducible genes activator"}}},"genes":[{"geneName":{"value":"oxyR"}}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250"}],"value":"Required for the induction of a regulon of hydrogen peroxide inducible genes such as catalase and glutathione-reductase"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Belongs to the LysR transcriptional regulatory family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":312,"modifier":"EXACT"}},"description":"Probable hydrogen peroxide-inducible genes activator","featureId":"PRO_0000105738"},{"type":"Domain","location":{"start":{"value":8,"modifier":"EXACT"},"end":{"value":65,"modifier":"EXACT"}},"description":"HTH lysR-type","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00253"}]},{"type":"DNA binding","location":{"start":{"value":25,"modifier":"EXACT"},"end":{"value":44,"modifier":"EXACT"}},"description":"H-T-H motif","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00253"}]}],"keywords":[{"id":"KW-0010","category":"Molecular function","name":"Activator"},{"id":"KW-0238","category":"Molecular function","name":"DNA-binding"},{"id":"KW-0804","category":"Biological process","name":"Transcription"},{"id":"KW-0805","category":"Biological process","name":"Transcription regulation"}],"references":[{"referenceNumber":1,"citation":{"id":"CI-4EDHAURCHH6SP","citationType":"submission","authors":["Ramachandran S.","Crawford D.L."],"title":"Genetic organization and sequence analysis of three peroxide induced regulatory genes oxyR, ahpC and ahpX in Streptomyces viridosporus T7A, a lignocellulose degrading organism.","publicationDate":"FEB-1999","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA]"],"referenceComments":[{"value":"T7A","type":"STRAIN"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AF127219","properties":[{"key":"ProteinId","value":"AAD25084.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"AlphaFoldDB","id":"Q9X5P2","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"Q9X5P2","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"AADKCFV","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"GO","id":"GO:0032993","properties":[{"key":"GoTerm","value":"C:protein-DNA complex"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:0003700","properties":[{"key":"GoTerm","value":"F:DNA-binding transcription factor activity"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"CDD","id":"cd08411","properties":[{"key":"EntryName","value":"PBP2_OxyR"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.10.10.10:FF:000001","properties":[{"key":"EntryName","value":"LysR family transcriptional regulator"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.40.190.10","properties":[{"key":"EntryName","value":"Periplasmic binding protein-like II"},{"key":"MatchStatus","value":"2"}]},{"database":"Gene3D","id":"1.10.10.10","properties":[{"key":"EntryName","value":"Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR000847","properties":[{"key":"EntryName","value":"LysR_HTH_N"}]},{"database":"InterPro","id":"IPR005119","properties":[{"key":"EntryName","value":"LysR_subst-bd"}]},{"database":"InterPro","id":"IPR036388","properties":[{"key":"EntryName","value":"WH-like_DNA-bd_sf"}]},{"database":"InterPro","id":"IPR036390","properties":[{"key":"EntryName","value":"WH_DNA-bd_sf"}]},{"database":"PANTHER","id":"PTHR30346:SF26","properties":[{"key":"EntryName","value":"HYDROGEN PEROXIDE-INDUCIBLE GENES ACTIVATOR"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR30346","properties":[{"key":"EntryName","value":"TRANSCRIPTIONAL DUAL REGULATOR HCAR-RELATED"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00126","properties":[{"key":"EntryName","value":"HTH_1"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF03466","properties":[{"key":"EntryName","value":"LysR_substrate"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR00039","properties":[{"key":"EntryName","value":"HTHLYSR"}]},{"database":"SUPFAM","id":"SSF53850","properties":[{"key":"EntryName","value":"Periplasmic binding protein-like II"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF46785","properties":[{"key":"EntryName","value":"Winged helix' DNA-binding domain"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50931","properties":[{"key":"EntryName","value":"HTH_LYSR"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MRKRRRQPSLAQLRAFAAVAEHLHFRDAAAAIGMSQPALSGAVSALEESLGVTLLERTTRKVLLSPAGERLAARAKSVLAEVGALVEEADALQAPFTGVLRLGVIPTVAPYVLPTVLRLVHDRYPRLDLQVHEEQTASLLDGLTGGRLDLLLLAVPLGVPGVVELPLFDEDFVLVTPLEHGLGGREGIPRKALRELNLLLLDEGHCLRDQALDICREAGSAGVAATTTAAGLSTLVQLVAGGLGVTLLPHTAVQVETTRSGRLLTGRFADPAPGRRIALAMRTGAARAAEYEELAAALREAMRDLPVRIVRD","length":312,"molWeight":33174,"crc64":"9D415FCBF7238D76","md5":"0084C7030DFCED871C793820D72F4A3A"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"SIMILARITY":1},"countByFeatureType":{"Chain":1,"Domain":1,"DNA binding":1},"uniParcId":"UPI0000130F85"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"Q9X5V0","uniProtkbId":"Q9X5V0_STRVD","entryAudit":{"firstPublicDate":"1999-11-01","lastAnnotationUpdateDate":"2026-11-04","lastSequenceUpdateDate":"1999-11-01","entryVersion":88,"sequenceVersion":1},"annotationScore":3.0,"organism":{"scientificName":"Streptomyces viridosporus","taxonId":67581,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAD33340.1"}],"lineage":["Bacteria","Bacillati","Actinomycetota","Actinomycetes","Kitasatosporales","Streptomycetaceae","Streptomyces"]},"proteinExistence":"3: Inferred from homology","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00017462"}],"value":"Alkyl hydroperoxide reductase C"},"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00067010"}],"value":"1.11.1.28"}]},"alternativeNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00032077"}],"value":"Peroxiredoxin"}},{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00032824"}],"value":"Thioredoxin peroxidase"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAD33340.1"}],"value":"ahpC"}}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00055957"}],"value":"Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides. Together with AhpD, DlaT and Lpd, constitutes an NADH-dependent peroxidase active against hydrogen and alkyl peroxides as well as serving as a peroxynitrite reductase, thus protecting the bacterium against reactive nitrogen intermediates and oxidative stress generated by the host immune system. Does not however seem to play a role in detoxification of isoniazid"}],"commentType":"FUNCTION"},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"N(6)-[(R)-dihydrolipoyl]-L-lysyl-[lipoyl-carrier protein] + a hydroperoxide = N(6)-[(R)-lipoyl]-L-lysyl-[lipoyl-carrier protein] + an alcohol + H2O","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:62636"},{"database":"Rhea","id":"RHEA-COMP:10502"},{"database":"Rhea","id":"RHEA-COMP:16355"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:30879"},{"database":"ChEBI","id":"CHEBI:35924"},{"database":"ChEBI","id":"CHEBI:83099"},{"database":"ChEBI","id":"CHEBI:83100"}],"ecNumber":"1.11.1.28","evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00051970"}]}},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00062350"}],"value":"Homodimer; disulfide-linked, upon oxidation. 6 homodimers assemble to form a ring-like dodecamer. Identified in a complex with AhpD, DlaT and Lpd"}],"commentType":"SUBUNIT"},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004496"}],"value":"Cytoplasm","id":"SL-0086"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00009796"}],"value":"Belongs to the peroxiredoxin family. AhpC/Prx1 subfamily"}],"commentType":"SIMILARITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00691"}],"value":"Lacks conserved residue(s) required for the propagation of feature annotation"}],"commentType":"CAUTION"}],"features":[{"type":"Domain","location":{"start":{"value":12,"modifier":"EXACT"},"end":{"value":170,"modifier":"EXACT"}},"description":"Thioredoxin","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS51352"}]},{"type":"Active site","location":{"start":{"value":61,"modifier":"EXACT"},"end":{"value":61,"modifier":"EXACT"}},"description":"Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity","evidences":[{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR000239-1"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022862"}],"id":"KW-0049","category":"Molecular function","name":"Antioxidant"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022490"}],"id":"KW-0963","category":"Cellular component","name":"Cytoplasm"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023157"}],"id":"KW-1015","category":"PTM","name":"Disulfide bond"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023002"}],"id":"KW-0560","category":"Molecular function","name":"Oxidoreductase"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022559"}],"id":"KW-0575","category":"Molecular function","name":"Peroxidase"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023284"}],"id":"KW-0676","category":"Domain","name":"Redox-active center"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023016"}],"id":"KW-0346","category":"Biological process","name":"Stress response"}],"references":[{"referenceNumber":1,"citation":{"id":"10902909","citationType":"journal article","authors":["Ramachandran S.","Magnuson T.S.","Crawford D.L."],"citationCrossReferences":[{"database":"PubMed","id":"10902909"}],"title":"Isolation and analysis of three peroxide sensor regulatory gene homologs ahpC, ahpX and oxyR in Streptomyces viridosporus T7A -- a lignocellulose degrading actinomycete.","publicationDate":"2000","journal":"DNA Seq.","firstPage":"51","lastPage":"60","volume":"11"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAD33340.1"}],"value":"T7A","type":"STRAIN"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAD33340.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AF127576","properties":[{"key":"ProteinId","value":"AAD33340.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"AlphaFoldDB","id":"Q9X5V0","properties":[{"key":"Description","value":"-"}]},{"database":"PeroxiBase","id":"5002","properties":[{"key":"EntryName","value":"SvAhpC"}]},{"database":"GO","id":"GO:0005829","properties":[{"key":"GoTerm","value":"C:cytosol"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:0160319","properties":[{"key":"GoTerm","value":"F:lipoyl-dependent peroxiredoxin activity"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-EC"}]},{"database":"GO","id":"GO:0008379","properties":[{"key":"GoTerm","value":"F:thioredoxin peroxidase activity"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:0045454","properties":[{"key":"GoTerm","value":"P:cell redox homeostasis"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniRule"}]},{"database":"GO","id":"GO:0033554","properties":[{"key":"GoTerm","value":"P:cellular response to stress"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:0042744","properties":[{"key":"GoTerm","value":"P:hydrogen peroxide catabolic process"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:0006979","properties":[{"key":"GoTerm","value":"P:response to oxidative stress"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"CDD","id":"cd03015","properties":[{"key":"EntryName","value":"PRX_Typ2cys"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.40.30.10:FF:000043","properties":[{"key":"EntryName","value":"Alkyl hydroperoxide reductase C"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.40.30.10","properties":[{"key":"EntryName","value":"Glutaredoxin"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR000866","properties":[{"key":"EntryName","value":"AhpC/TSA"}]},{"database":"InterPro","id":"IPR050217","properties":[{"key":"EntryName","value":"Peroxiredoxin"}]},{"database":"InterPro","id":"IPR024706","properties":[{"key":"EntryName","value":"Peroxiredoxin_AhpC-typ"}]},{"database":"InterPro","id":"IPR036249","properties":[{"key":"EntryName","value":"Thioredoxin-like_sf"}]},{"database":"InterPro","id":"IPR013766","properties":[{"key":"EntryName","value":"Thioredoxin_domain"}]},{"database":"PANTHER","id":"PTHR10681:SF121","properties":[{"key":"EntryName","value":"ALKYL HYDROPEROXIDE REDUCTASE C"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR10681","properties":[{"key":"EntryName","value":"THIOREDOXIN PEROXIDASE"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00578","properties":[{"key":"EntryName","value":"AhpC-TSA"},{"key":"MatchStatus","value":"1"}]},{"database":"PIRSF","id":"PIRSF000239","properties":[{"key":"EntryName","value":"AHPC"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF52833","properties":[{"key":"EntryName","value":"Thioredoxin-like"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS51352","properties":[{"key":"EntryName","value":"THIOREDOXIN_2"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MGASSLQGEPVLTVGDKFPEFELTACVSLEKGKEFETINHKTYEGKWKIVFAWPKDFTFVCPTEIAAFGKLNDEFADRDAQILGFSGDSEFVHHAWRKDHDDLRDLPFPMMADSKHELMRALGIEGEDGFAKRAVFIVDQNNEIQFTMVTAGSVGRNPKEVLRVLDALQTDELCPCNWTKGDETLDPVALLAGE","length":194,"molWeight":21700,"crc64":"F324A03842BC7AD1","md5":"796912A71BFD9988F4A4F877B7C03281"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"CATALYTIC ACTIVITY":1,"SUBUNIT":1,"SUBCELLULAR LOCATION":1,"SIMILARITY":1,"CAUTION":1},"countByFeatureType":{"Domain":1,"Active site":1},"uniParcId":"UPI00000B25FD"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0A000","uniProtkbId":"A0A000_STRVD","entryAudit":{"firstPublicDate":"2006-11-14","lastAnnotationUpdateDate":"2026-01-28","lastSequenceUpdateDate":"2006-11-14","entryVersion":53,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Streptomyces viridosporus","taxonId":67581,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ABJ90153.1"}],"lineage":["Bacteria","Bacillati","Actinomycetota","Actinomycetes","Kitasatosporales","Streptomycetaceae","Streptomyces"]},"proteinExistence":"3: Inferred from homology","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00013187"}],"value":"8-amino-7-oxononanoate synthase"},"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00013187"}],"value":"2.3.1.47"}]}},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ABJ90153.1"}],"value":"moeA5"}}],"comments":[{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"6-carboxyhexanoyl-[ACP] + L-alanine + H(+) = (8S)-8-amino-7-oxononanoate + holo-[ACP] + CO2","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:42288"},{"database":"Rhea","id":"RHEA-COMP:9685"},{"database":"Rhea","id":"RHEA-COMP:9955"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:16526"},{"database":"ChEBI","id":"CHEBI:57972"},{"database":"ChEBI","id":"CHEBI:64479"},{"database":"ChEBI","id":"CHEBI:78846"},{"database":"ChEBI","id":"CHEBI:149468"}],"ecNumber":"2.3.1.47","evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00047715"}]}},{"commentType":"COFACTOR","cofactors":[{"name":"pyridoxal 5'-phosphate","evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00001933"}],"cofactorCrossReference":{"database":"ChEBI","id":"CHEBI:597326"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00011738"}],"value":"Homodimer"}],"commentType":"SUBUNIT"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00008392"}],"value":"Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Domain","location":{"start":{"value":41,"modifier":"EXACT"},"end":{"value":381,"modifier":"EXACT"}},"description":"Aminotransferase class I/classII large","evidences":[{"evidenceCode":"ECO:0000259","source":"Pfam","id":"PF00155"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023315"}],"id":"KW-0012","category":"Molecular function","name":"Acyltransferase"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022898"}],"id":"KW-0663","category":"Ligand","name":"Pyridoxal phosphate"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022679"}],"id":"KW-0808","category":"Molecular function","name":"Transferase"}],"references":[{"referenceNumber":1,"citation":{"id":"CI-9LAJ522RF4IIS","citationType":"submission","authors":["Ostash B.O.","Walker S."],"publicationDate":"SEP-2006","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ABJ90153.1"}],"value":"ATCC14672","type":"STRAIN"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ABJ90153.1"}]},{"referenceNumber":2,"citation":{"id":"17379141","citationType":"journal article","authors":["Ostash B.","Saghatelian A.","Walker S."],"citationCrossReferences":[{"database":"PubMed","id":"17379141"},{"database":"DOI","id":"10.1016/j.chembiol.2007.01.008"}],"title":"A streamlined metabolic pathway for the biosynthesis of moenomycin A.","publicationDate":"2007","journal":"Chem. Biol.","firstPage":"257","lastPage":"267","volume":"14"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ABJ90153.1"}],"value":"ATCC14672","type":"STRAIN"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ABJ90153.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"DQ988994","properties":[{"key":"ProteinId","value":"ABJ90153.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"AlphaFoldDB","id":"A0A000","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"A0A000","properties":[{"key":"Description","value":"-"}]},{"database":"GO","id":"GO:0003870","properties":[{"key":"GoTerm","value":"F:5-aminolevulinate synthase activity"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0008710","properties":[{"key":"GoTerm","value":"F:8-amino-7-oxononanoate synthase activity"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-EC"}]},{"database":"GO","id":"GO:0030170","properties":[{"key":"GoTerm","value":"F:pyridoxal phosphate binding"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0033014","properties":[{"key":"GoTerm","value":"P:tetrapyrrole biosynthetic process"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"CDD","id":"cd06454","properties":[{"key":"EntryName","value":"KBL_like"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.40.640.10:FF:000006","properties":[{"key":"EntryName","value":"5-aminolevulinate synthase, mitochondrial"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.90.1150.10","properties":[{"key":"EntryName","value":"Aspartate Aminotransferase, domain 1"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.40.640.10","properties":[{"key":"EntryName","value":"Type I PLP-dependent aspartate aminotransferase-like (Major domain)"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR010961","properties":[{"key":"EntryName","value":"4pyrrol_synth_NH2levulA_synth"}]},{"database":"InterPro","id":"IPR004839","properties":[{"key":"EntryName","value":"Aminotransferase_I/II_large"}]},{"database":"InterPro","id":"IPR050087","properties":[{"key":"EntryName","value":"AON_synthase_class-II"}]},{"database":"InterPro","id":"IPR015424","properties":[{"key":"EntryName","value":"PyrdxlP-dep_Trfase"}]},{"database":"InterPro","id":"IPR015421","properties":[{"key":"EntryName","value":"PyrdxlP-dep_Trfase_major"}]},{"database":"InterPro","id":"IPR015422","properties":[{"key":"EntryName","value":"PyrdxlP-dep_Trfase_small"}]},{"database":"NCBIfam","id":"TIGR01821","properties":[{"key":"EntryName","value":"5aminolev_synth"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR13693:SF102","properties":[{"key":"EntryName","value":"2-AMINO-3-KETOBUTYRATE COENZYME A LIGASE, MITOCHONDRIAL"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR13693","properties":[{"key":"EntryName","value":"CLASS II AMINOTRANSFERASE/8-AMINO-7-OXONONANOATE SYNTHASE"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00155","properties":[{"key":"EntryName","value":"Aminotran_1_2"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF53383","properties":[{"key":"EntryName","value":"PLP-dependent transferases"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MDFFVRLARETGDRKREFLELGRKAGRFPAASTSNGEISIWCSNDYLGMGQHPDVLDAMKRSVDEYGGGSGGSRNTGGTNHFHVALEREPAEPHGKEDAVLFTSGYSANEGSLSVLAGAVDDCQVFSDSANHASIIDGLRHSGARKHVFRHKDGRHLEELLAAADRDKPKFIALESVHSMRGDIALLAEIAGLAKRYGAVTFLDEVHAVGMYGPGGAGIAARDGVHCEFTVVMGTLAKAFGMTGGYVAGPAVLMDAVRARARSFVFTTALPPAVAAGALAAVRHLRGSDEERRRPAENARLTHGLLRERDIPVLSDRSPIVPVLVGEDRMCKRMSALPLERHGAYVQAIDAPSVPAGEEILRIAPSAVHETEEIHRFVDALDGIWSELGAARRV","length":394,"molWeight":42315,"crc64":"F1DD0C1042811B48","md5":"E8872C7A0261B9E88E6FF47EB34E4162"},"extraAttributes":{"countByCommentType":{"CATALYTIC ACTIVITY":1,"COFACTOR":1,"SUBUNIT":1,"SIMILARITY":1},"countByFeatureType":{"Domain":1},"uniParcId":"UPI0000E5B23C"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0A001","uniProtkbId":"A0A001_STRVD","entryAudit":{"firstPublicDate":"2006-11-14","lastAnnotationUpdateDate":"2026-11-04","lastSequenceUpdateDate":"2006-11-14","entryVersion":75,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Streptomyces viridosporus","taxonId":67581,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ABJ90154.1"}],"lineage":["Bacteria","Bacillati","Actinomycetota","Actinomycetes","Kitasatosporales","Streptomycetaceae","Streptomyces"]},"proteinExistence":"4: Predicted","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ABJ90154.1"}],"value":"MoeD5"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ABJ90154.1"}],"value":"moeD5"}}],"comments":[{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004651"}],"value":"Cell membrane","id":"SL-0039"},"topology":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004651"}],"value":"Multi-pass membrane protein","id":"SL-9909"}}]}],"features":[{"type":"Transmembrane","location":{"start":{"value":9,"modifier":"EXACT"},"end":{"value":30,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00441"}]},{"type":"Transmembrane","location":{"start":{"value":42,"modifier":"EXACT"},"end":{"value":60,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00441"}]},{"type":"Transmembrane","location":{"start":{"value":116,"modifier":"EXACT"},"end":{"value":138,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00441"}]},{"type":"Transmembrane","location":{"start":{"value":144,"modifier":"EXACT"},"end":{"value":164,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00441"}]},{"type":"Transmembrane","location":{"start":{"value":232,"modifier":"EXACT"},"end":{"value":251,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00441"}]},{"type":"Transmembrane","location":{"start":{"value":263,"modifier":"EXACT"},"end":{"value":285,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00441"}]},{"type":"Domain","location":{"start":{"value":17,"modifier":"EXACT"},"end":{"value":289,"modifier":"EXACT"}},"description":"ABC transmembrane type-1","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50929"}]},{"type":"Domain","location":{"start":{"value":344,"modifier":"EXACT"},"end":{"value":573,"modifier":"EXACT"}},"description":"ABC transporter","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50893"}]},{"type":"Region","location":{"start":{"value":312,"modifier":"EXACT"},"end":{"value":340,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":571,"modifier":"EXACT"},"end":{"value":591,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Binding site","location":{"start":{"value":377,"modifier":"EXACT"},"end":{"value":384,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:30616"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00434"}],"ligand":{"name":"ATP","id":"ChEBI:CHEBI:30616"}}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022840"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00434"}],"id":"KW-0067","category":"Ligand","name":"ATP-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023136"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00441"}],"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022741"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00434"}],"id":"KW-0547","category":"Ligand","name":"Nucleotide-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022692"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00441"}],"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022989"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00441"}],"id":"KW-1133","category":"Domain","name":"Transmembrane helix"}],"references":[{"referenceNumber":1,"citation":{"id":"CI-9LAJ522RF4IIS","citationType":"submission","authors":["Ostash B.O.","Walker S."],"publicationDate":"SEP-2006","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ABJ90154.1"}],"value":"ATCC14672","type":"STRAIN"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ABJ90154.1"}]},{"referenceNumber":2,"citation":{"id":"17379141","citationType":"journal article","authors":["Ostash B.","Saghatelian A.","Walker S."],"citationCrossReferences":[{"database":"PubMed","id":"17379141"},{"database":"DOI","id":"10.1016/j.chembiol.2007.01.008"}],"title":"A streamlined metabolic pathway for the biosynthesis of moenomycin A.","publicationDate":"2007","journal":"Chem. Biol.","firstPage":"257","lastPage":"267","volume":"14"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ABJ90154.1"}],"value":"ATCC14672","type":"STRAIN"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ABJ90154.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"DQ988994","properties":[{"key":"ProteinId","value":"ABJ90154.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"AlphaFoldDB","id":"A0A001","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"A0A001","properties":[{"key":"Description","value":"-"}]},{"database":"GO","id":"GO:0043190","properties":[{"key":"GoTerm","value":"C:ATP-binding cassette (ABC) transporter complex"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniRule"}]},{"database":"GO","id":"GO:0140359","properties":[{"key":"GoTerm","value":"F:ABC-type transporter activity"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0005524","properties":[{"key":"GoTerm","value":"F:ATP binding"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniRule"}]},{"database":"GO","id":"GO:0016887","properties":[{"key":"GoTerm","value":"F:ATP hydrolysis activity"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"CDD","id":"cd03228","properties":[{"key":"EntryName","value":"ABCC_MRP_Like"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.20.1560.10","properties":[{"key":"EntryName","value":"ABC transporter type 1, transmembrane domain"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.40.50.300","properties":[{"key":"EntryName","value":"P-loop containing nucleotide triphosphate hydrolases"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR003593","properties":[{"key":"EntryName","value":"AAA+_ATPase"}]},{"database":"InterPro","id":"IPR011527","properties":[{"key":"EntryName","value":"ABC1_TM_dom"}]},{"database":"InterPro","id":"IPR036640","properties":[{"key":"EntryName","value":"ABC1_TM_sf"}]},{"database":"InterPro","id":"IPR003439","properties":[{"key":"EntryName","value":"ABC_transporter-like_ATP-bd"}]},{"database":"InterPro","id":"IPR017871","properties":[{"key":"EntryName","value":"ABC_transporter-like_CS"}]},{"database":"InterPro","id":"IPR027417","properties":[{"key":"EntryName","value":"P-loop_NTPase"}]},{"database":"InterPro","id":"IPR039421","properties":[{"key":"EntryName","value":"Type_1_exporter"}]},{"database":"PANTHER","id":"PTHR24221:SF423","properties":[{"key":"EntryName","value":"ABC TRANSPORTER"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR24221","properties":[{"key":"EntryName","value":"ATP-BINDING CASSETTE SUB-FAMILY B"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00664","properties":[{"key":"EntryName","value":"ABC_membrane"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00005","properties":[{"key":"EntryName","value":"ABC_tran"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00382","properties":[{"key":"EntryName","value":"AAA"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF90123","properties":[{"key":"EntryName","value":"ABC transporter transmembrane region"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF52540","properties":[{"key":"EntryName","value":"P-loop containing nucleoside triphosphate hydrolases"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50929","properties":[{"key":"EntryName","value":"ABC_TM1F"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00211","properties":[{"key":"EntryName","value":"ABC_TRANSPORTER_1"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50893","properties":[{"key":"EntryName","value":"ABC_TRANSPORTER_2"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MLRGSARTYWTLTGLWVLLRAGTLVVGLLFQRLFDALGAGGGVWLIIALVAAIEAGRLFLQFGVMINRLEPRVQYGTTARLRHALLGSALRGSEVTARTSPGESLRTVGEDVDETGFFVAWAPTNLAHWLFVAASVTVMMRIDAVVTGALLALLVLLTLVTALAHSRFLRHRRATRAASGEVAGALREMVGAVGAVQAAAAEPQVAAHVAGLNGARAEAAVREELYAVVQRTVIGNPAPIGVGVVLLLVAGRMDEGTFSVGDLALFAFYLQILTEALGSIGMLSVRLQRVSVALGRITNNLGCRLRRSLERASPPIASDAPGGTGEGAAAPDAGPEPAPPLRELAVRGLTARHPGAGHGIEDVDLVVERHTVTVVTGRVGSGKSTLVRAVLGLLPHERGTVLWNGEPIADPASFLVAPRCGYTPQVPCLFSGTVRENVLLGRDGAAFDEAVRLAVAEPDLAAMQDGPDTVVGPRGLRLSGGQIQRVAIARMLVGDPELVVLDDVSSALDPETEHLLWERLLDGTRTVLAVSHRPALLRAADRVVVLEGGRVEASGTFEEVMAVSAEMGRIWTGAGPGGGDAGPAPQSPPAG","length":591,"molWeight":61726,"crc64":"4F6121D422B63694","md5":"CB86C221BD1AC1E32E74CF89E2AE7499"},"extraAttributes":{"countByCommentType":{"SUBCELLULAR LOCATION":1},"countByFeatureType":{"Transmembrane":6,"Domain":2,"Region":2,"Binding site":1},"uniParcId":"UPI0000E5B23D"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0A004","uniProtkbId":"A0A004_STRVD","entryAudit":{"firstPublicDate":"2006-11-14","lastAnnotationUpdateDate":"2026-11-04","lastSequenceUpdateDate":"2006-11-14","entryVersion":65,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Streptomyces viridosporus","taxonId":67581,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ABJ90157.1"}],"lineage":["Bacteria","Bacillati","Actinomycetota","Actinomycetes","Kitasatosporales","Streptomycetaceae","Streptomyces"]},"proteinExistence":"3: Inferred from homology","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00012737"}],"value":"asparagine synthase (glutamine-hydrolyzing)"},"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00012737"}],"value":"6.3.5.4"}]}},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ABJ90157.1"}],"value":"moeF5"}}],"comments":[{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"L-aspartate + L-glutamine + ATP + H2O = L-asparagine + L-glutamate + AMP + diphosphate + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:12228"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:29985"},{"database":"ChEBI","id":"CHEBI:29991"},{"database":"ChEBI","id":"CHEBI:30616"},{"database":"ChEBI","id":"CHEBI:33019"},{"database":"ChEBI","id":"CHEBI:58048"},{"database":"ChEBI","id":"CHEBI:58359"},{"database":"ChEBI","id":"CHEBI:456215"}],"ecNumber":"6.3.5.4","evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00048741"}]}},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00005187"}],"value":"Amino-acid biosynthesis; L-asparagine biosynthesis; L-asparagine from L-aspartate (L-Gln route): step 1/1"}],"commentType":"PATHWAY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00005752"}],"value":"Belongs to the asparagine synthetase family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Domain","location":{"start":{"value":2,"modifier":"EXACT"},"end":{"value":209,"modifier":"EXACT"}},"description":"Glutamine amidotransferase type-2","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS51278"}]},{"type":"Active site","location":{"start":{"value":2,"modifier":"EXACT"},"end":{"value":2,"modifier":"EXACT"}},"description":"For GATase activity","evidences":[{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR001589-1"}]},{"type":"Active site","location":{"start":{"value":2,"modifier":"EXACT"},"end":{"value":2,"modifier":"EXACT"}},"description":"Nucleophile","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00609"}]},{"type":"Binding site","location":{"start":{"value":96,"modifier":"EXACT"},"end":{"value":96,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:58359"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR001589-2"}],"ligand":{"name":"L-glutamine","id":"ChEBI:CHEBI:58359"}},{"type":"Binding site","location":{"start":{"value":262,"modifier":"EXACT"},"end":{"value":262,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:30616"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR001589-2"}],"ligand":{"name":"ATP","id":"ChEBI:CHEBI:30616"}},{"type":"Site","location":{"start":{"value":365,"modifier":"EXACT"},"end":{"value":365,"modifier":"EXACT"}},"description":"Important for beta-aspartyl-AMP intermediate formation","evidences":[{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR001589-3"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR001589-1"}],"id":"KW-0028","category":"Biological process","name":"Amino-acid biosynthesis"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022888"},{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR001589-1"}],"id":"KW-0061","category":"Biological process","name":"Asparagine biosynthesis"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022840"},{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR001589-2"}],"id":"KW-0067","category":"Ligand","name":"ATP-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR001589-1"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00609"}],"id":"KW-0315","category":"Domain","name":"Glutamine amidotransferase"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022741"},{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR001589-2"}],"id":"KW-0547","category":"Ligand","name":"Nucleotide-binding"}],"references":[{"referenceNumber":1,"citation":{"id":"CI-9LAJ522RF4IIS","citationType":"submission","authors":["Ostash B.O.","Walker S."],"publicationDate":"SEP-2006","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ABJ90157.1"}],"value":"ATCC14672","type":"STRAIN"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ABJ90157.1"}]},{"referenceNumber":2,"citation":{"id":"17379141","citationType":"journal article","authors":["Ostash B.","Saghatelian A.","Walker S."],"citationCrossReferences":[{"database":"PubMed","id":"17379141"},{"database":"DOI","id":"10.1016/j.chembiol.2007.01.008"}],"title":"A streamlined metabolic pathway for the biosynthesis of moenomycin A.","publicationDate":"2007","journal":"Chem. Biol.","firstPage":"257","lastPage":"267","volume":"14"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ABJ90157.1"}],"value":"ATCC14672","type":"STRAIN"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ABJ90157.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"DQ988994","properties":[{"key":"ProteinId","value":"ABJ90157.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"AlphaFoldDB","id":"A0A004","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"A0A004","properties":[{"key":"Description","value":"-"}]},{"database":"GO","id":"GO:0005829","properties":[{"key":"GoTerm","value":"C:cytosol"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:0004066","properties":[{"key":"GoTerm","value":"F:asparagine synthase (glutamine-hydrolyzing) activity"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-EC"}]},{"database":"GO","id":"GO:0070981","properties":[{"key":"GoTerm","value":"P:L-asparagine biosynthetic process"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0006541","properties":[{"key":"GoTerm","value":"P:L-glutamine metabolic process"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniRule"}]},{"database":"CDD","id":"cd01991","properties":[{"key":"EntryName","value":"Asn_synthase_B_C"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.60.20.10","properties":[{"key":"EntryName","value":"Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.40.50.620","properties":[{"key":"EntryName","value":"HUPs"},{"key":"MatchStatus","value":"2"}]},{"database":"InterPro","id":"IPR006426","properties":[{"key":"EntryName","value":"Asn_synth_AEB"}]},{"database":"InterPro","id":"IPR001962","properties":[{"key":"EntryName","value":"Asn_synthase"}]},{"database":"InterPro","id":"IPR051786","properties":[{"key":"EntryName","value":"ASN_synthetase/amidase"}]},{"database":"InterPro","id":"IPR017932","properties":[{"key":"EntryName","value":"GATase_2_dom"}]},{"database":"InterPro","id":"IPR029055","properties":[{"key":"EntryName","value":"Ntn_hydrolases_N"}]},{"database":"InterPro","id":"IPR014729","properties":[{"key":"EntryName","value":"Rossmann-like_a/b/a_fold"}]},{"database":"NCBIfam","id":"TIGR01536","properties":[{"key":"EntryName","value":"asn_synth_AEB"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR43284:SF1","properties":[{"key":"EntryName","value":"ASPARAGINE SYNTHETASE"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR43284","properties":[{"key":"EntryName","value":"ASPARAGINE SYNTHETASE (GLUTAMINE-HYDROLYZING)"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00733","properties":[{"key":"EntryName","value":"Asn_synthase"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF13522","properties":[{"key":"EntryName","value":"GATase_6"},{"key":"MatchStatus","value":"1"}]},{"database":"PIRSF","id":"PIRSF001589","properties":[{"key":"EntryName","value":"Asn_synthetase_glu-h"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF52402","properties":[{"key":"EntryName","value":"Adenine nucleotide alpha hydrolases-like"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF56235","properties":[{"key":"EntryName","value":"N-terminal nucleophile aminohydrolases (Ntn hydrolases)"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS51278","properties":[{"key":"EntryName","value":"GATASE_TYPE_2"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MCGFVGFSDAGAGQEDARVTAERMLAAVAHRGPDGSDWCHHRGVTLAHCALTFTDPDHGAQPFVSASGATAVVFNGELYNHAVLGDGALPCAPGGDTEVPGGTLRVAGHADARPAAGHVRLRAAGRPHRHHGAGRDRWGRAPLLTPACETDIAFASELTSLLRHPAAPRTPEVRALADYLVLQAFCAPASAVSGVCKVRPGSYVTHRHGALDETEFWRPRLTPDRGAGRGPGRREAARRFEELFRAAVARRMTSTDRRLGVLLSGGLDSSAVAAVAQQLLPGRPVPTFSAGFADPDFDESDHARAVARHLGTEHHVVRIGGADLAGVVESELAVADEPLADPSLLPTRLVCRAAREHVRGVLTGDGADELLLGYRYFQAERAIELLLRVLPAPRLEALVRLLVRRLPARSGNLPVTHALGLLAKGLRAAPEHRFYLSTAPFGPGELPRLLTPEAGAELTGHDPFTEVSRLLRGQPGLTGVQRSQLAVVTHFLRDVILTKTDRGGMRSSLELRSPFLDLDLVEYGNSLPTGLKLHRFTGKYLLRQVAAGWLPPSVVQRTKLGFRAPVAALLRGELRPLLLDTLSPSSLRRGGLFDTGAVRLLIDDHLGGRRDTSRKLWALLVYQLWFESLTAGPRALESPAYPALS","length":645,"molWeight":69267,"crc64":"D762860BE0292BFC","md5":"8814E3F3CBC538DA38990175F0D7426D"},"extraAttributes":{"countByCommentType":{"CATALYTIC ACTIVITY":1,"PATHWAY":1,"SIMILARITY":1},"countByFeatureType":{"Domain":1,"Active site":2,"Binding site":2,"Site":1},"uniParcId":"UPI0000E5B240"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"Q000A4","uniProtkbId":"Q000A4_STRVD","entryAudit":{"firstPublicDate":"2006-11-14","lastAnnotationUpdateDate":"2026-11-04","lastSequenceUpdateDate":"2006-11-14","entryVersion":56,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Streptomyces viridosporus","taxonId":67581,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ABJ90148.1"}],"lineage":["Bacteria","Bacillati","Actinomycetota","Actinomycetes","Kitasatosporales","Streptomycetaceae","Streptomyces"]},"proteinExistence":"3: Inferred from homology","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00013187"}],"value":"8-amino-7-oxononanoate synthase"},"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00013187"}],"value":"2.3.1.47"}]}},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ABJ90148.1"}],"value":"moeC4"}}],"comments":[{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"6-carboxyhexanoyl-[ACP] + L-alanine + H(+) = (8S)-8-amino-7-oxononanoate + holo-[ACP] + CO2","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:42288"},{"database":"Rhea","id":"RHEA-COMP:9685"},{"database":"Rhea","id":"RHEA-COMP:9955"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:16526"},{"database":"ChEBI","id":"CHEBI:57972"},{"database":"ChEBI","id":"CHEBI:64479"},{"database":"ChEBI","id":"CHEBI:78846"},{"database":"ChEBI","id":"CHEBI:149468"}],"ecNumber":"2.3.1.47","evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00047715"}]}},{"commentType":"COFACTOR","cofactors":[{"name":"pyridoxal 5'-phosphate","evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00001933"}],"cofactorCrossReference":{"database":"ChEBI","id":"CHEBI:597326"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00011738"}],"value":"Homodimer"}],"commentType":"SUBUNIT"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00008392"}],"value":"Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Domain","location":{"start":{"value":53,"modifier":"EXACT"},"end":{"value":393,"modifier":"EXACT"}},"description":"Aminotransferase class I/classII large","evidences":[{"evidenceCode":"ECO:0000259","source":"Pfam","id":"PF00155"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023315"}],"id":"KW-0012","category":"Molecular function","name":"Acyltransferase"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022898"}],"id":"KW-0663","category":"Ligand","name":"Pyridoxal phosphate"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022679"}],"id":"KW-0808","category":"Molecular function","name":"Transferase"}],"references":[{"referenceNumber":1,"citation":{"id":"CI-9LAJ522RF4IIS","citationType":"submission","authors":["Ostash B.O.","Walker S."],"publicationDate":"SEP-2006","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ABJ90148.1"}],"value":"ATCC14672","type":"STRAIN"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ABJ90148.1"}]},{"referenceNumber":2,"citation":{"id":"17379141","citationType":"journal article","authors":["Ostash B.","Saghatelian A.","Walker S."],"citationCrossReferences":[{"database":"PubMed","id":"17379141"},{"database":"DOI","id":"10.1016/j.chembiol.2007.01.008"}],"title":"A streamlined metabolic pathway for the biosynthesis of moenomycin A.","publicationDate":"2007","journal":"Chem. Biol.","firstPage":"257","lastPage":"267","volume":"14"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ABJ90148.1"}],"value":"ATCC14672","type":"STRAIN"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ABJ90148.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"DQ988993","properties":[{"key":"ProteinId","value":"ABJ90148.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"RefSeq","id":"WP_004978594.1","properties":[{"key":"NucleotideSequenceId","value":"NZ_JBPUKI010000031.1"}]},{"database":"AlphaFoldDB","id":"Q000A4","properties":[{"key":"Description","value":"-"}]},{"database":"GO","id":"GO:0003870","properties":[{"key":"GoTerm","value":"F:5-aminolevulinate synthase activity"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0008710","properties":[{"key":"GoTerm","value":"F:8-amino-7-oxononanoate synthase activity"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-EC"}]},{"database":"GO","id":"GO:0030170","properties":[{"key":"GoTerm","value":"F:pyridoxal phosphate binding"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0033014","properties":[{"key":"GoTerm","value":"P:tetrapyrrole biosynthetic process"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"CDD","id":"cd06454","properties":[{"key":"EntryName","value":"KBL_like"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.40.640.10:FF:000006","properties":[{"key":"EntryName","value":"5-aminolevulinate synthase, mitochondrial"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.90.1150.10","properties":[{"key":"EntryName","value":"Aspartate Aminotransferase, domain 1"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.40.640.10","properties":[{"key":"EntryName","value":"Type I PLP-dependent aspartate aminotransferase-like (Major domain)"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR010961","properties":[{"key":"EntryName","value":"4pyrrol_synth_NH2levulA_synth"}]},{"database":"InterPro","id":"IPR004839","properties":[{"key":"EntryName","value":"Aminotransferase_I/II_large"}]},{"database":"InterPro","id":"IPR050087","properties":[{"key":"EntryName","value":"AON_synthase_class-II"}]},{"database":"InterPro","id":"IPR015424","properties":[{"key":"EntryName","value":"PyrdxlP-dep_Trfase"}]},{"database":"InterPro","id":"IPR015421","properties":[{"key":"EntryName","value":"PyrdxlP-dep_Trfase_major"}]},{"database":"InterPro","id":"IPR015422","properties":[{"key":"EntryName","value":"PyrdxlP-dep_Trfase_small"}]},{"database":"NCBIfam","id":"TIGR01821","properties":[{"key":"EntryName","value":"5aminolev_synth"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR13693:SF102","properties":[{"key":"EntryName","value":"2-AMINO-3-KETOBUTYRATE COENZYME A LIGASE, MITOCHONDRIAL"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR13693","properties":[{"key":"EntryName","value":"CLASS II AMINOTRANSFERASE/8-AMINO-7-OXONONANOATE SYNTHASE"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00155","properties":[{"key":"EntryName","value":"Aminotran_1_2"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF53383","properties":[{"key":"EntryName","value":"PLP-dependent transferases"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MTTQYLDLFARLTENSDGGKREFLEIGRLAGSFPAASVRSSGPVTGRDSISVWCSNDYLGMGQHPAVLKAMKDAIDEYGAGAGGSRNIGGTNHYHVLLERELAALHGKDEALLFTSGYTANDGALSVIAGRMEKCVVFSDALNHASIIDGLRHSRAQKQIFRHNDPAHLEELIAAADPDVPKLIVAESVYSMNGDIAPLSEIADIAKRHGAMTYLDEVHAVGMYGPEGAGIAAREGIADDFTVIMGTLAKGFGTTGGYIAGPAEIIEAVRMFSRSFVFTTALAPAVAAGALAAVHHLRSSEVEREQLWSNAQLMHRLLNERGIPFISDQTHIVSVMVGDEAVCKRMSALLLDRHGIYVQAINAPSVRVGEEILRVAPGAVHTADDVREFVDALSQVWEEVGSARVPATPAAL","length":412,"molWeight":43994,"crc64":"AAC12738BD56622B","md5":"C2D4B780C99CE801472C6BE96CCE2D22"},"extraAttributes":{"countByCommentType":{"CATALYTIC ACTIVITY":1,"COFACTOR":1,"SUBUNIT":1,"SIMILARITY":1},"countByFeatureType":{"Domain":1},"uniParcId":"UPI0000E5B237"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"Q84HN8","uniProtkbId":"Q84HN8_STRVD","entryAudit":{"firstPublicDate":"2003-06-01","lastAnnotationUpdateDate":"2026-11-04","lastSequenceUpdateDate":"2003-06-01","entryVersion":110,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Streptomyces viridosporus","taxonId":67581,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAO25844.1"}],"lineage":["Bacteria","Bacillati","Actinomycetota","Actinomycetes","Kitasatosporales","Streptomycetaceae","Streptomyces"]},"proteinExistence":"4: Predicted","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAO25844.1"}],"value":"PksE"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAO25844.1"}],"value":"pksE"}}],"comments":[{"commentType":"COFACTOR","cofactors":[{"name":"pantetheine 4'-phosphate","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00258"}],"cofactorCrossReference":{"database":"ChEBI","id":"CHEBI:47942"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004792"}],"value":"Antibiotic biosynthesis"}],"commentType":"PATHWAY"}],"features":[{"type":"Domain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":462,"modifier":"EXACT"}},"description":"Ketosynthase family 3 (KS3)","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS52004"}]},{"type":"Domain","location":{"start":{"value":955,"modifier":"EXACT"},"end":{"value":1031,"modifier":"EXACT"}},"description":"Carrier","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50075"}]},{"type":"Domain","location":{"start":{"value":1465,"modifier":"EXACT"},"end":{"value":1748,"modifier":"EXACT"}},"description":"PKS/mFAS DH","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS52019"}]},{"type":"Region","location":{"start":{"value":902,"modifier":"EXACT"},"end":{"value":954,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":1465,"modifier":"EXACT"},"end":{"value":1588,"modifier":"EXACT"}},"description":"N-terminal hotdog fold","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU01363"}]},{"type":"Region","location":{"start":{"value":1600,"modifier":"EXACT"},"end":{"value":1748,"modifier":"EXACT"}},"description":"C-terminal hotdog fold","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU01363"}]},{"type":"Compositional bias","location":{"start":{"value":935,"modifier":"EXACT"},"end":{"value":948,"modifier":"EXACT"}},"description":"Low complexity","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Active site","location":{"start":{"value":1497,"modifier":"EXACT"},"end":{"value":1497,"modifier":"EXACT"}},"description":"Proton acceptor; for dehydratase activity","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU01363"}]},{"type":"Active site","location":{"start":{"value":1667,"modifier":"EXACT"},"end":{"value":1667,"modifier":"EXACT"}},"description":"Proton donor; for dehydratase activity","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU01363"}]},{"type":"Modified residue","location":{"start":{"value":990,"modifier":"EXACT"},"end":{"value":990,"modifier":"EXACT"}},"description":"O-(pantetheine 4'-phosphoryl)serine","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00258"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023315"}],"id":"KW-0012","category":"Molecular function","name":"Acyltransferase"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023194"}],"id":"KW-0045","category":"Biological process","name":"Antibiotic biosynthesis"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023268"}],"id":"KW-0511","category":"Molecular function","name":"Multifunctional enzyme"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022450"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00258"}],"id":"KW-0596","category":"PTM","name":"Phosphopantetheine"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022553"}],"id":"KW-0597","category":"PTM","name":"Phosphoprotein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022679"}],"id":"KW-0808","category":"Molecular function","name":"Transferase"}],"references":[{"referenceNumber":1,"citation":{"id":"12536216","citationType":"journal article","authors":["Zazopoulos E.","Huang K.","Staffa A.","Liu W.","Bachmann B.O.","Nonaka K.","Ahlert J.","Thorson J.S.","Shen B.","Farnet C.M."],"citationCrossReferences":[{"database":"PubMed","id":"12536216"},{"database":"DOI","id":"10.1038/nbt784"}],"title":"A genomics-guided approach for discovering and expressing cryptic metabolic pathways.","publicationDate":"2003","journal":"Nat. Biotechnol.","firstPage":"187","lastPage":"190","volume":"21"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAO25844.1"}],"value":"NRRL B-12104","type":"STRAIN"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAO25844.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AF546141","properties":[{"key":"ProteinId","value":"AAO25844.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"GO","id":"GO:0004312","properties":[{"key":"GoTerm","value":"F:fatty acid synthase activity"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:0006633","properties":[{"key":"GoTerm","value":"P:fatty acid biosynthetic process"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"CDD","id":"cd08953","properties":[{"key":"EntryName","value":"KR_2_SDR_x"},{"key":"MatchStatus","value":"1"}]},{"database":"CDD","id":"cd00833","properties":[{"key":"EntryName","value":"PKS"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.40.47.10","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.10.1200.10","properties":[{"key":"EntryName","value":"ACP-like"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.40.366.10","properties":[{"key":"EntryName","value":"Malonyl-Coenzyme A Acyl Carrier Protein, domain 2"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.40.50.720","properties":[{"key":"EntryName","value":"NAD(P)-binding Rossmann-like Domain"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.10.129.110","properties":[{"key":"EntryName","value":"Polyketide synthase dehydratase"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR001227","properties":[{"key":"EntryName","value":"Ac_transferase_dom_sf"}]},{"database":"InterPro","id":"IPR036736","properties":[{"key":"EntryName","value":"ACP-like_sf"}]},{"database":"InterPro","id":"IPR014043","properties":[{"key":"EntryName","value":"Acyl_transferase_dom"}]},{"database":"InterPro","id":"IPR016035","properties":[{"key":"EntryName","value":"Acyl_Trfase/lysoPLipase"}]},{"database":"InterPro","id":"IPR014031","properties":[{"key":"EntryName","value":"KAS_C"}]},{"database":"InterPro","id":"IPR014030","properties":[{"key":"EntryName","value":"KAS_N"}]},{"database":"InterPro","id":"IPR057326","properties":[{"key":"EntryName","value":"KR_dom"}]},{"database":"InterPro","id":"IPR016036","properties":[{"key":"EntryName","value":"Malonyl_transacylase_ACP-bd"}]},{"database":"InterPro","id":"IPR036291","properties":[{"key":"EntryName","value":"NAD(P)-bd_dom_sf"}]},{"database":"InterPro","id":"IPR032821","properties":[{"key":"EntryName","value":"PKS_assoc"}]},{"database":"InterPro","id":"IPR020841","properties":[{"key":"EntryName","value":"PKS_Beta-ketoAc_synthase_dom"}]},{"database":"InterPro","id":"IPR042104","properties":[{"key":"EntryName","value":"PKS_dehydratase_sf"}]},{"database":"InterPro","id":"IPR020807","properties":[{"key":"EntryName","value":"PKS_DH"}]},{"database":"InterPro","id":"IPR049551","properties":[{"key":"EntryName","value":"PKS_DH_C"}]},{"database":"InterPro","id":"IPR049552","properties":[{"key":"EntryName","value":"PKS_DH_N"}]},{"database":"InterPro","id":"IPR013968","properties":[{"key":"EntryName","value":"PKS_KR"}]},{"database":"InterPro","id":"IPR049900","properties":[{"key":"EntryName","value":"PKS_mFAS_DH"}]},{"database":"InterPro","id":"IPR050091","properties":[{"key":"EntryName","value":"PKS_NRPS_Biosynth_Enz"}]},{"database":"InterPro","id":"IPR009081","properties":[{"key":"EntryName","value":"PP-bd_ACP"}]},{"database":"InterPro","id":"IPR016039","properties":[{"key":"EntryName","value":"Thiolase-like"}]},{"database":"PANTHER","id":"PTHR43775","properties":[{"key":"EntryName","value":"FATTY ACID SYNTHASE"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR43775:SF51","properties":[{"key":"EntryName","value":"INACTIVE PHENOLPHTHIOCEROL SYNTHESIS POLYKETIDE SYNTHASE TYPE I PKS1-RELATED"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00698","properties":[{"key":"EntryName","value":"Acyl_transf_1"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF16197","properties":[{"key":"EntryName","value":"KAsynt_C_assoc"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00109","properties":[{"key":"EntryName","value":"ketoacyl-synt"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF02801","properties":[{"key":"EntryName","value":"Ketoacyl-synt_C"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF08659","properties":[{"key":"EntryName","value":"KR"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF21089","properties":[{"key":"EntryName","value":"PKS_DH_N"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF14765","properties":[{"key":"EntryName","value":"PS-DH"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00827","properties":[{"key":"EntryName","value":"PKS_AT"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00826","properties":[{"key":"EntryName","value":"PKS_DH"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00822","properties":[{"key":"EntryName","value":"PKS_KR"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00825","properties":[{"key":"EntryName","value":"PKS_KS"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF47336","properties":[{"key":"EntryName","value":"ACP-like"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF52151","properties":[{"key":"EntryName","value":"FabD/lysophospholipase-like"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF51735","properties":[{"key":"EntryName","value":"NAD(P)-binding Rossmann-fold domains"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF55048","properties":[{"key":"EntryName","value":"Probable ACP-binding domain of malonyl-CoA ACP transacylase"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF53901","properties":[{"key":"EntryName","value":"Thiolase-like"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50075","properties":[{"key":"EntryName","value":"CARRIER"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS52004","properties":[{"key":"EntryName","value":"KS3_2"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS52019","properties":[{"key":"EntryName","value":"PKS_MFAS_DH"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MTRIAIVGMACRYPDATDPKELWDNAVAGRRAFRRLPDVRMNLDDYWDADPTTPDTFYARNAAVIEGYEFDRIAHKIAGSTFRSTDLTHWLALDTAGRALADAGFPGGEGLPRERTGVVVGNTLTGEFSRANVMRLRWPYVRRVMAAALKDEQDWDEDRIARFLDDVETAYKEPFPAIDEDTLAGGLANTIAGRICNHFDLNGGGYTVDGACSSSLLSVTTAGTALINGDIDVAVAGGVDLSIDPFEIIGFAKTGALAKGEMRLYDRGSNGFWPGEGCGMIVLMREEDALAAGHRIYATIAGWGVSSDGQGGITRPEVSGYQLALRRAYERAGFGIETVGLFEGHGTGTAVGDTTELTALSDARRRADPDAPAAAITSIKGMIGHTKAAAGVAGLIKAAMAVNHQVLPPSIGTIDPHALLTDDNATLKALRKAEPWPTGAPRRAGVTAMGFGGINTHVVLDEPAGRRRTAPSRRSATLAHTPQDCELLVLDGESPKALHARLTEVAAFVAQVSYGQVADLAATLQRELRGLSHRAAVVVTSPEDAERRLTHLADLLQTGETSYTAADGRGFLGRATRPARIGFLFPGQGSGHGTVGGALCRRFPEAAEVFARAALPATGDMTATNVAQPRIATGSAAGLRVLDALRLEASVAVGHSLGELSALHWAGALDEETLLQAARVRGRAMAEHSATGTMASLAAAPERAEELLADLDAVIAGYNGPEQTVIAGSPADIEELQRRAERAEVTCTRLNVSHAFHSPLVAHSAEVFGAWLAEARLGSPSGRVVSTVTGEELTAGTDLAALLTEQITGPVRFTRAVSEAARHVDLFVEVGPGRVLSGLARATTGVPAVALNTDDESLRSALAVAGAAFVAGAPVALERFFEDRLIRPLRVGQEFSFLANPCEQAPREKAPAGRRPRPVTPAAETPHDAHPAPTPADATTAAEAPTTEEAPEDGAGALEVLRVLVAERAELPAELVDPDSRLLDDLHMSSITVGQIVNQAASRLGIAAAQVPTNFATATLAELAEALDTLVDTGTTGEPTTSAVVGAAPWARPFAVDLDEVARPHAAADGADGDWELFAPQDHPYAERLRRELAGAGVGAGVVAVLPKGCARQEVDRVLAAAHSALAGDRTRRFVLVQDGRGAAGLAKTLYLEAPHLRTTVVHTPAAQDVVERVVAEVAATTRFTEVHYDEAGVRRVPTLRALPVAPQHTASPLDASDVLLVTGGGKGISAECALAVAQRTGAALAVLGRSDPASDRELADNIERMRAGGARVHYARADVTVPEQVTAAVAELTERLGTITALLHGAGRNEPNALARLAPRDFERTFAPKVDGLRTVLDAVDPGNLKLLVTFGSIIGRAGLRGEAHYATANEWLADLTEEVARAHPNLRARCMEWSVWSGVGMGEKLSVVESLSREGITPVSPDQGVDILLRLIEDPDAPVVTVVSGRTEGIDTVRRDLPDLPMLRFTGNPLVRYHGVELVTEVELNAGTDPYLSDHLLDGNLLLPAVIGMEAMAQVASAVTGRTGVPVIEDAEFLRPIVVPPSGSTRIRIAAVVTAPDTVDVAVHAEDTGFVAEHFRARLLFTGAAVPDGPPLQVPDDTPVVPLDPATDLYGGILFQGARFQRLHRFHRAAARHVDAEVAVQQRPEGWFAGFLPGRLLLADPGMRDALMHGNQVCVPDATLLPSGVERIHALGSGEHVPDRLRYTAVERSRDGDTYVYDIAVRDENGVVVERWDGLTLHAVRKTDGSGPWVAPLLGPYLERSLEDVTGSRIAVAVEPHGDAPAGSVAQRRGFTADAAARALGSPVAVRHRPDGRPELEPDRHLSVSAAHGLGVTLSAVSDTEVACDIEAVSMRSAHEWRGLLGEHAVAAELVAKETGEAPDTAATRVWGAVECLRKAGIMAGAPLTVLPRRKDAWVVFAAGDLRIATFVTALRDALEPAVFAFLTHEPQSAQERG","length":1956,"molWeight":206628,"crc64":"8D24A06B63524824","md5":"A525F022FBFA1B17535E3DCD4AB7ED99"},"extraAttributes":{"countByCommentType":{"COFACTOR":1,"PATHWAY":1},"countByFeatureType":{"Domain":3,"Region":3,"Compositional bias":1,"Active site":2,"Modified residue":1},"uniParcId":"UPI0000003D2D"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"X2KV47","uniProtkbId":"X2KV47_STRVD","entryAudit":{"firstPublicDate":"2014-06-11","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2014-06-11","entryVersion":28,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Streptomyces viridosporus","taxonId":67581,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AHN92592.1"}],"lineage":["Bacteria","Bacillati","Actinomycetota","Actinomycetes","Kitasatosporales","Streptomycetaceae","Streptomyces"]},"proteinExistence":"3: Inferred from homology","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00012895"}],"value":"DNA topoisomerase (ATP-hydrolyzing)"},"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00012895"}],"value":"5.6.2.2"}]},"flag":"Fragment"},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AHN92592.1"}],"value":"gyrB"}}],"comments":[{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"ATP-dependent breakage, passage and rejoining of double-stranded DNA.","ecNumber":"5.6.2.2","evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00000185"}]}},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00010708"}],"value":"Belongs to the type II topoisomerase GyrB family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Non-terminal residue","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":1,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AHN92592.1"}]},{"type":"Non-terminal residue","location":{"start":{"value":135,"modifier":"EXACT"},"end":{"value":135,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AHN92592.1"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022840"}],"id":"KW-0067","category":"Ligand","name":"ATP-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023125"}],"id":"KW-0238","category":"Molecular function","name":"DNA-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023235"}],"id":"KW-0413","category":"Molecular function","name":"Isomerase"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022741"}],"id":"KW-0547","category":"Ligand","name":"Nucleotide-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023029"}],"id":"KW-0799","category":"Molecular function","name":"Topoisomerase"}],"references":[{"referenceNumber":1,"citation":{"id":"24604690","citationType":"journal article","authors":["Busarakam K.","Bull A.T.","Girard G.","Labeda D.P.","van Wezel G.P.","Goodfellow M."],"citationCrossReferences":[{"database":"PubMed","id":"24604690"},{"database":"DOI","id":"10.1007/s10482-014-0139-y"}],"title":"Streptomyces leeuwenhoekii sp. nov., the producer of chaxalactins and chaxamycins, forms a distinct branch in Streptomyces gene trees.","publicationDate":"2014","journal":"Antonie Van Leeuwenhoek","firstPage":"849","lastPage":"861","volume":"105"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AHN92592.1"}],"value":"NRRL B-12104","type":"STRAIN"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AHN92592.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"KJ137042","properties":[{"key":"ProteinId","value":"AHN92592.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"AlphaFoldDB","id":"X2KV47","properties":[{"key":"Description","value":"-"}]},{"database":"GO","id":"GO:0005524","properties":[{"key":"GoTerm","value":"F:ATP binding"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0003677","properties":[{"key":"GoTerm","value":"F:DNA binding"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0003918","properties":[{"key":"GoTerm","value":"F:DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-EC"}]},{"database":"GO","id":"GO:0006265","properties":[{"key":"GoTerm","value":"P:DNA topological change"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"Gene3D","id":"3.30.565.10","properties":[{"key":"EntryName","value":"Histidine kinase-like ATPase, C-terminal domain"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR036890","properties":[{"key":"EntryName","value":"HATPase_C_sf"}]},{"database":"InterPro","id":"IPR000565","properties":[{"key":"EntryName","value":"Topo_IIA_B"}]},{"database":"PANTHER","id":"PTHR45866:SF1","properties":[{"key":"EntryName","value":"DNA GYRASE SUBUNIT B, MITOCHONDRIAL"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR45866","properties":[{"key":"EntryName","value":"DNA GYRASE/TOPOISOMERASE SUBUNIT B"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR01159","properties":[{"key":"EntryName","value":"DNAGYRASEB"}]},{"database":"SUPFAM","id":"SSF55874","properties":[{"key":"EntryName","value":"ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"LHGVGVSVVNALSTRVAVEVKTDGYRWTQDYKLGVPTAPLAKHEATEETGTSVTFWADPDIFETTDYSFETLSRRFQEMAFLNKGLRINLTDERESAKATAGADEAGEDEKYEVKAVSYHYEGGIVDFVKYLNSR","length":135,"molWeight":15077,"crc64":"47C982B83E61523E","md5":"81D64DF22E87573D238E8636B948A06A"},"extraAttributes":{"countByCommentType":{"CATALYTIC ACTIVITY":1,"SIMILARITY":1},"countByFeatureType":{"Non-terminal residue":2},"uniParcId":"UPI00043B0B67"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"X2KZ28","secondaryAccessions":["A0A1L2FSB2"],"uniProtkbId":"X2KZ28_STRVD","entryAudit":{"firstPublicDate":"2014-06-11","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2014-06-11","entryVersion":45,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Streptomyces viridosporus","taxonId":67581,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AHN92576.1"}],"lineage":["Bacteria","Bacillati","Actinomycetota","Actinomycetes","Kitasatosporales","Streptomycetaceae","Streptomyces"]},"proteinExistence":"3: Inferred from homology","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00015553"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000526"}],"value":"Protein RecA"}},"alternativeNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00033319"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000526"}],"value":"Recombinase A"}}],"flag":"Fragment"},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AHN92576.1"}],"value":"recA"}}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000526"}],"value":"Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00009391"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU004527"}],"value":"Belongs to the RecA family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Domain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":148,"modifier":"EXACT"}},"description":"RecA family profile 1","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50162"}]},{"type":"Domain","location":{"start":{"value":153,"modifier":"EXACT"},"end":{"value":168,"modifier":"EXACT"}},"description":"RecA family profile 2","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50163"}]},{"type":"Non-terminal residue","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":1,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AHN92576.1"}]},{"type":"Non-terminal residue","location":{"start":{"value":168,"modifier":"EXACT"},"end":{"value":168,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AHN92576.1"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022840"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU004527"}],"id":"KW-0067","category":"Ligand","name":"ATP-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU004527"}],"id":"KW-0227","category":"Biological process","name":"DNA damage"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023172"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU004527"}],"id":"KW-0233","category":"Biological process","name":"DNA recombination"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000526"}],"id":"KW-0234","category":"Biological process","name":"DNA repair"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU004527"}],"id":"KW-0238","category":"Molecular function","name":"DNA-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022741"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU004527"}],"id":"KW-0547","category":"Ligand","name":"Nucleotide-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000526"}],"id":"KW-0742","category":"Biological process","name":"SOS response"}],"references":[{"referenceNumber":1,"citation":{"id":"24604690","citationType":"journal article","authors":["Busarakam K.","Bull A.T.","Girard G.","Labeda D.P.","van Wezel G.P.","Goodfellow M."],"citationCrossReferences":[{"database":"PubMed","id":"24604690"},{"database":"DOI","id":"10.1007/s10482-014-0139-y"}],"title":"Streptomyces leeuwenhoekii sp. nov., the producer of chaxalactins and chaxamycins, forms a distinct branch in Streptomyces gene trees.","publicationDate":"2014","journal":"Antonie Van Leeuwenhoek","firstPage":"849","lastPage":"861","volume":"105"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AHN92576.1"}],"value":"NRRL B-12104","type":"STRAIN"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AHN92576.1"}]},{"referenceNumber":2,"citation":{"id":"CI-4H78J3L514OKB","citationType":"submission","authors":["Labeda D.P.","Rong X.","Huang Y.","Doroghazi J.R.","Ju K.-S.","Metcalf W.W."],"title":"Evaluation of the family Streptomycetaceae using multi-locus sequence analysis.","publicationDate":"AUG-2015","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AOA50913.1"}],"value":"NRRL ISP-5243","type":"STRAIN"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AOA50913.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"KJ137060","properties":[{"key":"ProteinId","value":"AHN92576.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"KT385460","properties":[{"key":"ProteinId","value":"AOA50913.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"AlphaFoldDB","id":"X2KZ28","properties":[{"key":"Description","value":"-"}]},{"database":"GO","id":"GO:0005829","properties":[{"key":"GoTerm","value":"C:cytosol"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:0005524","properties":[{"key":"GoTerm","value":"F:ATP binding"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0140664","properties":[{"key":"GoTerm","value":"F:ATP-dependent DNA damage sensor activity"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0003697","properties":[{"key":"GoTerm","value":"F:single-stranded DNA binding"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0006281","properties":[{"key":"GoTerm","value":"P:DNA repair"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"CDD","id":"cd00983","properties":[{"key":"EntryName","value":"RecA"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.40.50.300","properties":[{"key":"EntryName","value":"P-loop containing nucleotide triphosphate hydrolases"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR003593","properties":[{"key":"EntryName","value":"AAA+_ATPase"}]},{"database":"InterPro","id":"IPR013765","properties":[{"key":"EntryName","value":"DNA_recomb/repair_RecA"}]},{"database":"InterPro","id":"IPR027417","properties":[{"key":"EntryName","value":"P-loop_NTPase"}]},{"database":"InterPro","id":"IPR049428","properties":[{"key":"EntryName","value":"RecA-like_N"}]},{"database":"InterPro","id":"IPR020588","properties":[{"key":"EntryName","value":"RecA_ATP-bd"}]},{"database":"InterPro","id":"IPR020587","properties":[{"key":"EntryName","value":"RecA_monomer-monomer_interface"}]},{"database":"NCBIfam","id":"TIGR02012","properties":[{"key":"EntryName","value":"tigrfam_recA"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR45900:SF1","properties":[{"key":"EntryName","value":"MITOCHONDRIAL DNA REPAIR PROTEIN RECA HOMOLOG-RELATED"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR45900","properties":[{"key":"EntryName","value":"RECA"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00154","properties":[{"key":"EntryName","value":"RecA_N"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR00142","properties":[{"key":"EntryName","value":"RECA"}]},{"database":"SMART","id":"SM00382","properties":[{"key":"EntryName","value":"AAA"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF52540","properties":[{"key":"EntryName","value":"P-loop containing nucleoside triphosphate hydrolases"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50162","properties":[{"key":"EntryName","value":"RECA_2"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50163","properties":[{"key":"EntryName","value":"RECA_3"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"DVALGVGGLPRGRVVEIYGPESSGKTTLTLHAVANAQKAGGQVAFVDAEHALDPEYAKKLGVDIDNLILSQPDNGEQALEIVDMLVRSGALDLIVIDSVAALVPRAEIEGEMGDSHVGLQARLMSQALRKITSALNQSKTTAIFINQLREKIGVMFGSPETTTGGRAL","length":168,"molWeight":17658,"crc64":"E292DC7867671104","md5":"EBC52DFC33009830C9D15518DDE17888"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"SIMILARITY":1},"countByFeatureType":{"Domain":2,"Non-terminal residue":2},"uniParcId":"UPI0000E6AF3B"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"X2KZ63","uniProtkbId":"X2KZ63_STRVD","entryAudit":{"firstPublicDate":"2014-06-11","lastAnnotationUpdateDate":"2026-01-28","lastSequenceUpdateDate":"2014-06-11","entryVersion":37,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Streptomyces viridosporus","taxonId":67581,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AHN92626.1"}],"lineage":["Bacteria","Bacillati","Actinomycetota","Actinomycetes","Kitasatosporales","Streptomycetaceae","Streptomyces"]},"proteinExistence":"3: Inferred from homology","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00012043"}],"value":"tryptophan synthase"},"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00012043"}],"value":"4.2.1.20"}]},"flag":"Fragment"},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AHN92626.1"}],"value":"trpB"}}],"comments":[{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"(1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + L-serine = D-glyceraldehyde 3-phosphate + L-tryptophan + H2O","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:10532"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:33384"},{"database":"ChEBI","id":"CHEBI:57912"},{"database":"ChEBI","id":"CHEBI:58866"},{"database":"ChEBI","id":"CHEBI:59776"}],"ecNumber":"4.2.1.20","evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00049047"}]}},{"commentType":"COFACTOR","cofactors":[{"name":"pyridoxal 5'-phosphate","evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00001933"}],"cofactorCrossReference":{"database":"ChEBI","id":"CHEBI:597326"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004733"}],"value":"Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 5/5"}],"commentType":"PATHWAY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00011270"}],"value":"Tetramer of two alpha and two beta chains"}],"commentType":"SUBUNIT"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00009982"}],"value":"Belongs to the TrpB family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Domain","location":{"start":{"value":2,"modifier":"EXACT"},"end":{"value":148,"modifier":"EXACT"}},"description":"Tryptophan synthase beta chain-like PALP","evidences":[{"evidenceCode":"ECO:0000259","source":"Pfam","id":"PF00291"}]},{"type":"Non-terminal residue","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":1,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AHN92626.1"}]},{"type":"Non-terminal residue","location":{"start":{"value":190,"modifier":"EXACT"},"end":{"value":190,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AHN92626.1"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022605"}],"id":"KW-0028","category":"Biological process","name":"Amino-acid biosynthesis"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023141"}],"id":"KW-0057","category":"Biological process","name":"Aromatic amino acid biosynthesis"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023239"}],"id":"KW-0456","category":"Molecular function","name":"Lyase"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022898"}],"id":"KW-0663","category":"Ligand","name":"Pyridoxal phosphate"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022822"}],"id":"KW-0822","category":"Biological process","name":"Tryptophan biosynthesis"}],"references":[{"referenceNumber":1,"citation":{"id":"24604690","citationType":"journal article","authors":["Busarakam K.","Bull A.T.","Girard G.","Labeda D.P.","van Wezel G.P.","Goodfellow M."],"citationCrossReferences":[{"database":"PubMed","id":"24604690"},{"database":"DOI","id":"10.1007/s10482-014-0139-y"}],"title":"Streptomyces leeuwenhoekii sp. nov., the producer of chaxalactins and chaxamycins, forms a distinct branch in Streptomyces gene trees.","publicationDate":"2014","journal":"Antonie Van Leeuwenhoek","firstPage":"849","lastPage":"861","volume":"105"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AHN92626.1"}],"value":"NRRL B-12104","type":"STRAIN"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AHN92626.1"}]},{"referenceNumber":2,"citation":{"id":"CI-4H78J3L514OKB","citationType":"submission","authors":["Labeda D.P.","Rong X.","Huang Y.","Doroghazi J.R.","Ju K.-S.","Metcalf W.W."],"title":"Evaluation of the family Streptomycetaceae using multi-locus sequence analysis.","publicationDate":"AUG-2015","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AOA51612.1"}],"value":"NRRL ISP-5243","type":"STRAIN"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AOA51612.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"KJ137093","properties":[{"key":"ProteinId","value":"AHN92626.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"KT389427","properties":[{"key":"ProteinId","value":"AOA51612.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"AlphaFoldDB","id":"X2KZ63","properties":[{"key":"Description","value":"-"}]},{"database":"GO","id":"GO:0005737","properties":[{"key":"GoTerm","value":"C:cytoplasm"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:0004834","properties":[{"key":"GoTerm","value":"F:tryptophan synthase activity"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-EC"}]},{"database":"Gene3D","id":"3.40.50.1100","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"2"}]},{"database":"InterPro","id":"IPR023026","properties":[{"key":"EntryName","value":"Trp_synth_beta/beta-like"}]},{"database":"InterPro","id":"IPR001926","properties":[{"key":"EntryName","value":"TrpB-like_PALP"}]},{"database":"InterPro","id":"IPR036052","properties":[{"key":"EntryName","value":"TrpB-like_PALP_sf"}]},{"database":"PANTHER","id":"PTHR48077:SF3","properties":[{"key":"EntryName","value":"TRYPTOPHAN SYNTHASE"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR48077","properties":[{"key":"EntryName","value":"TRYPTOPHAN SYNTHASE-RELATED"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00291","properties":[{"key":"EntryName","value":"PALP"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF53686","properties":[{"key":"EntryName","value":"Tryptophan synthase beta subunit-like PLP-dependent enzymes"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"QHGVATATACALFGLDCTIYMGEIDTRRQALNVARMRMLGAEVIAVKSGSRTLKDAINEAFRDWVANVESTHYLFGTVAGPHPFPAMVRDFHRVIGVEARRQLLERAGRLPDAAVACVGGGSNAIGLFHAFIPDASVRLIGCEPAGHGVETGEHAATLTAGEPGILHGSRSYVLQDDEGQITEPYSISAG","length":190,"molWeight":20139,"crc64":"22A9A956FD74F037","md5":"1AB725466FB15630A6F18D820324C050"},"extraAttributes":{"countByCommentType":{"CATALYTIC ACTIVITY":1,"COFACTOR":1,"PATHWAY":1,"SUBUNIT":1,"SIMILARITY":1},"countByFeatureType":{"Domain":1,"Non-terminal residue":2},"uniParcId":"UPI00043ACA2C"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0A002","uniProtkbId":"A0A002_STRVD","entryAudit":{"firstPublicDate":"2006-11-14","lastAnnotationUpdateDate":"2026-11-04","lastSequenceUpdateDate":"2006-11-14","entryVersion":71,"sequenceVersion":1},"annotationScore":1.0,"organism":{"scientificName":"Streptomyces viridosporus","taxonId":67581,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ABJ90155.1"}],"lineage":["Bacteria","Bacillati","Actinomycetota","Actinomycetes","Kitasatosporales","Streptomycetaceae","Streptomyces"]},"proteinExistence":"4: Predicted","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ABJ90155.1"}],"value":"MoeJ5"}}]},"comments":[{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004651"}],"value":"Cell membrane","id":"SL-0039"},"topology":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004651"}],"value":"Multi-pass membrane protein","id":"SL-9909"}}]}],"features":[{"type":"Transmembrane","location":{"start":{"value":7,"modifier":"EXACT"},"end":{"value":29,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00441"}]},{"type":"Transmembrane","location":{"start":{"value":49,"modifier":"EXACT"},"end":{"value":70,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00441"}]},{"type":"Transmembrane","location":{"start":{"value":116,"modifier":"EXACT"},"end":{"value":142,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00441"}]},{"type":"Transmembrane","location":{"start":{"value":148,"modifier":"EXACT"},"end":{"value":167,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00441"}]},{"type":"Transmembrane","location":{"start":{"value":230,"modifier":"EXACT"},"end":{"value":254,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00441"}]},{"type":"Transmembrane","location":{"start":{"value":260,"modifier":"EXACT"},"end":{"value":279,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00441"}]},{"type":"Domain","location":{"start":{"value":17,"modifier":"EXACT"},"end":{"value":291,"modifier":"EXACT"}},"description":"ABC transmembrane type-1","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50929"}]},{"type":"Domain","location":{"start":{"value":324,"modifier":"EXACT"},"end":{"value":558,"modifier":"EXACT"}},"description":"ABC transporter","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50893"}]},{"type":"Binding site","location":{"start":{"value":357,"modifier":"EXACT"},"end":{"value":364,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:30616"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00434"}],"ligand":{"name":"ATP","id":"ChEBI:CHEBI:30616"}}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022840"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00434"}],"id":"KW-0067","category":"Ligand","name":"ATP-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023136"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00441"}],"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022741"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00434"}],"id":"KW-0547","category":"Ligand","name":"Nucleotide-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022692"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00441"}],"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022989"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00441"}],"id":"KW-1133","category":"Domain","name":"Transmembrane helix"}],"references":[{"referenceNumber":1,"citation":{"id":"CI-9LAJ522RF4IIS","citationType":"submission","authors":["Ostash B.O.","Walker S."],"publicationDate":"SEP-2006","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ABJ90155.1"}],"value":"ATCC14672","type":"STRAIN"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ABJ90155.1"}]},{"referenceNumber":2,"citation":{"id":"17379141","citationType":"journal article","authors":["Ostash B.","Saghatelian A.","Walker S."],"citationCrossReferences":[{"database":"PubMed","id":"17379141"},{"database":"DOI","id":"10.1016/j.chembiol.2007.01.008"}],"title":"A streamlined metabolic pathway for the biosynthesis of moenomycin A.","publicationDate":"2007","journal":"Chem. Biol.","firstPage":"257","lastPage":"267","volume":"14"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ABJ90155.1"}],"value":"ATCC14672","type":"STRAIN"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ABJ90155.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"DQ988994","properties":[{"key":"ProteinId","value":"ABJ90155.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"AlphaFoldDB","id":"A0A002","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"A0A002","properties":[{"key":"Description","value":"-"}]},{"database":"GO","id":"GO:0043190","properties":[{"key":"GoTerm","value":"C:ATP-binding cassette (ABC) transporter complex"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniRule"}]},{"database":"GO","id":"GO:0140359","properties":[{"key":"GoTerm","value":"F:ABC-type transporter activity"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0005524","properties":[{"key":"GoTerm","value":"F:ATP binding"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniRule"}]},{"database":"GO","id":"GO:0016887","properties":[{"key":"GoTerm","value":"F:ATP hydrolysis activity"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"CDD","id":"cd07346","properties":[{"key":"EntryName","value":"ABC_6TM_exporters"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.20.1560.10","properties":[{"key":"EntryName","value":"ABC transporter type 1, transmembrane domain"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.40.50.300","properties":[{"key":"EntryName","value":"P-loop containing nucleotide triphosphate hydrolases"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR003593","properties":[{"key":"EntryName","value":"AAA+_ATPase"}]},{"database":"InterPro","id":"IPR011527","properties":[{"key":"EntryName","value":"ABC1_TM_dom"}]},{"database":"InterPro","id":"IPR036640","properties":[{"key":"EntryName","value":"ABC1_TM_sf"}]},{"database":"InterPro","id":"IPR003439","properties":[{"key":"EntryName","value":"ABC_transporter-like_ATP-bd"}]},{"database":"InterPro","id":"IPR027417","properties":[{"key":"EntryName","value":"P-loop_NTPase"}]},{"database":"InterPro","id":"IPR039421","properties":[{"key":"EntryName","value":"Type_1_exporter"}]},{"database":"PANTHER","id":"PTHR24221","properties":[{"key":"EntryName","value":"ATP-BINDING CASSETTE SUB-FAMILY B"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR24221:SF654","properties":[{"key":"EntryName","value":"ATP-BINDING CASSETTE SUB-FAMILY B MEMBER 6"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00664","properties":[{"key":"EntryName","value":"ABC_membrane"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00005","properties":[{"key":"EntryName","value":"ABC_tran"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00382","properties":[{"key":"EntryName","value":"AAA"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF90123","properties":[{"key":"EntryName","value":"ABC transporter transmembrane region"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF52540","properties":[{"key":"EntryName","value":"P-loop containing nucleoside triphosphate hydrolases"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50929","properties":[{"key":"EntryName","value":"ABC_TM1F"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50893","properties":[{"key":"EntryName","value":"ABC_TRANSPORTER_2"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MRGERTAVALLALLVPAGMGLQLVAPYLLRGFIDGALSGDSRKTLLDLAAWSLAAAVGTLVVTAGTEALSSRVAWRSTNRLRADLVEHCLSRPPGFYRKHPPGELVERMDGDVTRLAAVMSTLLLELLAQALLIVGILVALFRLEWRLALVVAPFAAGTLLLLRTLVGRAMPFVTARQRVAADLQGFLEERLAAAEDLRVNGASRYTLRELGDRQDDLYRKARDAARASVRWPATVQGLSAVSVVLALAVSAWLHARGQLSTGTAFASLSYAMLLRRPLLAVTTRFRELEDAAASAQRLRDLLGHGTAAPRTGRGTLPAGLPGVRFDGVSFGYEPDEPVLRDVSFTLRPGERLGVVGRTGSGKSTVVRLLFGLHHPGAGSVSAGGLDLTEIDPRALRSRVALVTQEVHVFHASLRDNLTFFDRSVPDDRLRAALGEAGLGPWLRTLPDGLDTPLGAGARGMSAGEEQQLALARVFLRDPGLVLMDEPTARLDPYSERLLMPALERLLEGRTAVVVEHRPHLLRNVDRILVLEEGKVAEEGERRVLAADPGSRFHALLRTAGATR","length":564,"molWeight":60863,"crc64":"B41A3E92A6CB830E","md5":"BFA4D3AA927A6BA10AF8368EA54B99EF"},"extraAttributes":{"countByCommentType":{"SUBCELLULAR LOCATION":1},"countByFeatureType":{"Transmembrane":6,"Domain":2,"Binding site":1},"uniParcId":"UPI0000E5B23E"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0A003","uniProtkbId":"A0A003_STRVD","entryAudit":{"firstPublicDate":"2006-11-14","lastAnnotationUpdateDate":"2026-11-04","lastSequenceUpdateDate":"2006-11-14","entryVersion":59,"sequenceVersion":1},"annotationScore":1.0,"organism":{"scientificName":"Streptomyces viridosporus","taxonId":67581,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ABJ90156.1"}],"lineage":["Bacteria","Bacillati","Actinomycetota","Actinomycetes","Kitasatosporales","Streptomycetaceae","Streptomyces"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ABJ90156.1"}],"value":"MoeE5"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ABJ90156.1"}],"value":"moeE5"}}],"features":[{"type":"Domain","location":{"start":{"value":15,"modifier":"EXACT"},"end":{"value":249,"modifier":"EXACT"}},"description":"NAD-dependent epimerase/dehydratase","evidences":[{"evidenceCode":"ECO:0000259","source":"Pfam","id":"PF01370"}]},{"type":"Region","location":{"start":{"value":321,"modifier":"EXACT"},"end":{"value":340,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":328,"modifier":"EXACT"},"end":{"value":340,"modifier":"EXACT"}},"description":"Low complexity","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Binding site","location":{"start":{"value":23,"modifier":"EXACT"},"end":{"value":23,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:57540"}],"evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6KV9"},{"evidenceCode":"ECO:0007829","source":"PDB","id":"6KVC"}],"ligand":{"name":"NAD(+)","id":"ChEBI:CHEBI:57540"}},{"type":"Binding site","location":{"start":{"value":24,"modifier":"EXACT"},"end":{"value":24,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:57540"}],"evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6KV9"},{"evidenceCode":"ECO:0007829","source":"PDB","id":"6KVC"}],"ligand":{"name":"NAD(+)","id":"ChEBI:CHEBI:57540"}},{"type":"Binding site","location":{"start":{"value":43,"modifier":"EXACT"},"end":{"value":43,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:57540"}],"evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6KV9"},{"evidenceCode":"ECO:0007829","source":"PDB","id":"6KVC"}],"ligand":{"name":"NAD(+)","id":"ChEBI:CHEBI:57540"}},{"type":"Binding site","location":{"start":{"value":68,"modifier":"EXACT"},"end":{"value":68,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:57540"}],"evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6KV9"},{"evidenceCode":"ECO:0007829","source":"PDB","id":"6KVC"}],"ligand":{"name":"NAD(+)","id":"ChEBI:CHEBI:57540"}},{"type":"Binding site","location":{"start":{"value":69,"modifier":"EXACT"},"end":{"value":69,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:57540"}],"evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6KV9"},{"evidenceCode":"ECO:0007829","source":"PDB","id":"6KVC"}],"ligand":{"name":"NAD(+)","id":"ChEBI:CHEBI:57540"}},{"type":"Binding site","location":{"start":{"value":87,"modifier":"EXACT"},"end":{"value":87,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:57540"}],"evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6KV9"},{"evidenceCode":"ECO:0007829","source":"PDB","id":"6KVC"}],"ligand":{"name":"NAD(+)","id":"ChEBI:CHEBI:57540"}},{"type":"Binding site","location":{"start":{"value":89,"modifier":"EXACT"},"end":{"value":89,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:57540"}],"evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6KV9"},{"evidenceCode":"ECO:0007829","source":"PDB","id":"6KVC"}],"ligand":{"name":"NAD(+)","id":"ChEBI:CHEBI:57540"}},{"type":"Binding site","location":{"start":{"value":91,"modifier":"EXACT"},"end":{"value":91,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:58885"}],"evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6KVC"}],"ligand":{"name":"UDP-alpha-D-glucose","id":"ChEBI:CHEBI:58885"}},{"type":"Binding site","location":{"start":{"value":91,"modifier":"EXACT"},"end":{"value":91,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:58052"}],"evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6KV9"}],"ligand":{"name":"UDP-alpha-D-glucuronate","id":"ChEBI:CHEBI:58052"}},{"type":"Binding site","location":{"start":{"value":94,"modifier":"EXACT"},"end":{"value":94,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:58885"}],"evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6KVC"}],"ligand":{"name":"UDP-alpha-D-glucose","id":"ChEBI:CHEBI:58885"}},{"type":"Binding site","location":{"start":{"value":94,"modifier":"EXACT"},"end":{"value":94,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:58052"}],"evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6KV9"}],"ligand":{"name":"UDP-alpha-D-glucuronate","id":"ChEBI:CHEBI:58052"}},{"type":"Binding site","location":{"start":{"value":106,"modifier":"EXACT"},"end":{"value":106,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:57540"}],"evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6KV9"},{"evidenceCode":"ECO:0007829","source":"PDB","id":"6KVC"}],"ligand":{"name":"NAD(+)","id":"ChEBI:CHEBI:57540"}},{"type":"Binding site","location":{"start":{"value":131,"modifier":"EXACT"},"end":{"value":131,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:58052"}],"evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6KV9"}],"ligand":{"name":"UDP-alpha-D-glucuronate","id":"ChEBI:CHEBI:58052"}},{"type":"Binding site","location":{"start":{"value":132,"modifier":"EXACT"},"end":{"value":132,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:58052"}],"evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6KV9"}],"ligand":{"name":"UDP-alpha-D-glucuronate","id":"ChEBI:CHEBI:58052"}},{"type":"Binding site","location":{"start":{"value":133,"modifier":"EXACT"},"end":{"value":133,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:58052"}],"evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6KV9"}],"ligand":{"name":"UDP-alpha-D-glucuronate","id":"ChEBI:CHEBI:58052"}},{"type":"Binding site","location":{"start":{"value":154,"modifier":"EXACT"},"end":{"value":154,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:57540"}],"evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6KV9"},{"evidenceCode":"ECO:0007829","source":"PDB","id":"6KVC"}],"ligand":{"name":"NAD(+)","id":"ChEBI:CHEBI:57540"}},{"type":"Binding site","location":{"start":{"value":158,"modifier":"EXACT"},"end":{"value":158,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:57540"}],"evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6KV9"},{"evidenceCode":"ECO:0007829","source":"PDB","id":"6KVC"}],"ligand":{"name":"NAD(+)","id":"ChEBI:CHEBI:57540"}},{"type":"Binding site","location":{"start":{"value":183,"modifier":"EXACT"},"end":{"value":183,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:58885"}],"evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6KVC"}],"ligand":{"name":"UDP-alpha-D-glucose","id":"ChEBI:CHEBI:58885"}},{"type":"Binding site","location":{"start":{"value":185,"modifier":"EXACT"},"end":{"value":185,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:58885"}],"evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6KVC"}],"ligand":{"name":"UDP-alpha-D-glucose","id":"ChEBI:CHEBI:58885"}},{"type":"Binding site","location":{"start":{"value":185,"modifier":"EXACT"},"end":{"value":185,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:58052"}],"evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6KV9"}],"ligand":{"name":"UDP-alpha-D-glucuronate","id":"ChEBI:CHEBI:58052"}},{"type":"Binding site","location":{"start":{"value":186,"modifier":"EXACT"},"end":{"value":186,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:57540"}],"evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6KV9"},{"evidenceCode":"ECO:0007829","source":"PDB","id":"6KVC"}],"ligand":{"name":"NAD(+)","id":"ChEBI:CHEBI:57540"}},{"type":"Binding site","location":{"start":{"value":192,"modifier":"EXACT"},"end":{"value":192,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:57540"}],"evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6KV9"},{"evidenceCode":"ECO:0007829","source":"PDB","id":"6KVC"}],"ligand":{"name":"NAD(+)","id":"ChEBI:CHEBI:57540"}},{"type":"Binding site","location":{"start":{"value":192,"modifier":"EXACT"},"end":{"value":192,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:58885"}],"evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6KVC"}],"ligand":{"name":"UDP-alpha-D-glucose","id":"ChEBI:CHEBI:58885"}},{"type":"Binding site","location":{"start":{"value":192,"modifier":"EXACT"},"end":{"value":192,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:58052"}],"evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6KV9"}],"ligand":{"name":"UDP-alpha-D-glucuronate","id":"ChEBI:CHEBI:58052"}},{"type":"Binding site","location":{"start":{"value":196,"modifier":"EXACT"},"end":{"value":196,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:58885"}],"evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6KVC"}],"ligand":{"name":"UDP-alpha-D-glucose","id":"ChEBI:CHEBI:58885"}},{"type":"Binding site","location":{"start":{"value":196,"modifier":"EXACT"},"end":{"value":196,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:58052"}],"evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6KV9"}],"ligand":{"name":"UDP-alpha-D-glucuronate","id":"ChEBI:CHEBI:58052"}},{"type":"Binding site","location":{"start":{"value":199,"modifier":"EXACT"},"end":{"value":199,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:58885"}],"evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6KVC"}],"ligand":{"name":"UDP-alpha-D-glucose","id":"ChEBI:CHEBI:58885"}},{"type":"Binding site","location":{"start":{"value":199,"modifier":"EXACT"},"end":{"value":199,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:58052"}],"evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6KV9"}],"ligand":{"name":"UDP-alpha-D-glucuronate","id":"ChEBI:CHEBI:58052"}},{"type":"Binding site","location":{"start":{"value":211,"modifier":"EXACT"},"end":{"value":211,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:58885"}],"evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6KVC"}],"ligand":{"name":"UDP-alpha-D-glucose","id":"ChEBI:CHEBI:58885"}},{"type":"Binding site","location":{"start":{"value":211,"modifier":"EXACT"},"end":{"value":211,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:58052"}],"evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6KV9"}],"ligand":{"name":"UDP-alpha-D-glucuronate","id":"ChEBI:CHEBI:58052"}},{"type":"Binding site","location":{"start":{"value":213,"modifier":"EXACT"},"end":{"value":213,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:58885"}],"evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6KVC"}],"ligand":{"name":"UDP-alpha-D-glucose","id":"ChEBI:CHEBI:58885"}},{"type":"Binding site","location":{"start":{"value":213,"modifier":"EXACT"},"end":{"value":213,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:58052"}],"evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6KV9"}],"ligand":{"name":"UDP-alpha-D-glucuronate","id":"ChEBI:CHEBI:58052"}},{"type":"Binding site","location":{"start":{"value":218,"modifier":"EXACT"},"end":{"value":218,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:58885"}],"evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6KVC"}],"ligand":{"name":"UDP-alpha-D-glucose","id":"ChEBI:CHEBI:58885"}},{"type":"Binding site","location":{"start":{"value":218,"modifier":"EXACT"},"end":{"value":218,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:58052"}],"evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6KV9"}],"ligand":{"name":"UDP-alpha-D-glucuronate","id":"ChEBI:CHEBI:58052"}},{"type":"Binding site","location":{"start":{"value":220,"modifier":"EXACT"},"end":{"value":220,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:58885"}],"evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6KVC"}],"ligand":{"name":"UDP-alpha-D-glucose","id":"ChEBI:CHEBI:58885"}},{"type":"Binding site","location":{"start":{"value":220,"modifier":"EXACT"},"end":{"value":220,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:58052"}],"evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6KV9"}],"ligand":{"name":"UDP-alpha-D-glucuronate","id":"ChEBI:CHEBI:58052"}},{"type":"Binding site","location":{"start":{"value":282,"modifier":"EXACT"},"end":{"value":282,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:58885"}],"evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6KVC"}],"ligand":{"name":"UDP-alpha-D-glucose","id":"ChEBI:CHEBI:58885"}},{"type":"Binding site","location":{"start":{"value":282,"modifier":"EXACT"},"end":{"value":282,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:58052"}],"evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6KV9"}],"ligand":{"name":"UDP-alpha-D-glucuronate","id":"ChEBI:CHEBI:58052"}}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6KV9"},{"evidenceCode":"ECO:0007829","source":"PDB","id":"6KVC"}],"id":"KW-0002","category":"Technical term","name":"3D-structure"},{"evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6KV9"},{"evidenceCode":"ECO:0007829","source":"PDB","id":"6KVC"}],"id":"KW-0547","category":"Ligand","name":"Nucleotide-binding"}],"references":[{"referenceNumber":1,"citation":{"id":"CI-9LAJ522RF4IIS","citationType":"submission","authors":["Ostash B.O.","Walker S."],"publicationDate":"SEP-2006","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ABJ90156.1"}],"value":"ATCC14672","type":"STRAIN"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ABJ90156.1"}]},{"referenceNumber":2,"citation":{"id":"17379141","citationType":"journal article","authors":["Ostash B.","Saghatelian A.","Walker S."],"citationCrossReferences":[{"database":"PubMed","id":"17379141"},{"database":"DOI","id":"10.1016/j.chembiol.2007.01.008"}],"title":"A streamlined metabolic pathway for the biosynthesis of moenomycin A.","publicationDate":"2007","journal":"Chem. Biol.","firstPage":"257","lastPage":"267","volume":"14"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ABJ90156.1"}],"value":"ATCC14672","type":"STRAIN"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ABJ90156.1"}]},{"referenceNumber":3,"citation":{"id":"31653344","citationType":"journal article","authors":["Sun H.","Ko T.P.","Liu W.","Liu W.","Zheng Y.","Chen C.C.","Guo R.T."],"citationCrossReferences":[{"database":"PubMed","id":"31653344"},{"database":"DOI","id":"10.1016/j.bbrc.2019.10.035"}],"title":"Structure of an antibiotic-synthesizing UDP-glucuronate 4-epimerase MoeE5 in complex with substrate.","publicationDate":"2020","journal":"Biochem. Biophys. Res. Commun.","firstPage":"31","lastPage":"36","volume":"521"},"referencePositions":["X-RAY CRYSTALLOGRAPHY (1.48 ANGSTROMS) IN COMPLEX WITH NAD(+); UDP-ALPHA-D-GLUCOSE AND UDP-ALPHA-D-GLUCURONATE"],"evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6KV9"},{"evidenceCode":"ECO:0007829","source":"PDB","id":"6KVC"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"DQ988994","properties":[{"key":"ProteinId","value":"ABJ90156.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"RefSeq","id":"WP_223887129.1","properties":[{"key":"NucleotideSequenceId","value":"NZ_JBVHZE010000004.1"}]},{"database":"PDB","id":"6KV9","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.48 A"},{"key":"Chains","value":"A=1-340"}]},{"database":"PDB","id":"6KVC","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.66 A"},{"key":"Chains","value":"A=1-340"}]},{"database":"AlphaFoldDB","id":"A0A003","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"A0A003","properties":[{"key":"Description","value":"-"}]},{"database":"GeneID","id":"307735497","properties":[{"key":"Description","value":"-"}]},{"database":"BRENDA","id":"5.1.3.6","properties":[{"key":"OrganismId","value":"6117"}]},{"database":"Gene3D","id":"3.40.50.720","properties":[{"key":"EntryName","value":"NAD(P)-binding Rossmann-like Domain"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR001509","properties":[{"key":"EntryName","value":"Epimerase_deHydtase"}]},{"database":"InterPro","id":"IPR050177","properties":[{"key":"EntryName","value":"Lipid_A_modif_metabolic_enz"}]},{"database":"InterPro","id":"IPR036291","properties":[{"key":"EntryName","value":"NAD(P)-bd_dom_sf"}]},{"database":"PANTHER","id":"PTHR43245","properties":[{"key":"EntryName","value":"BIFUNCTIONAL POLYMYXIN RESISTANCE PROTEIN ARNA"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR43245:SF23","properties":[{"key":"EntryName","value":"NAD(P)-BINDING DOMAIN-CONTAINING PROTEIN"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF01370","properties":[{"key":"EntryName","value":"Epimerase"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR01713","properties":[{"key":"EntryName","value":"NUCEPIMERASE"}]},{"database":"SUPFAM","id":"SSF51735","properties":[{"key":"EntryName","value":"NAD(P)-binding Rossmann-fold domains"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MSSDTHGTDLADGDVLVTGAAGFIGSHLVTELRNSGRNVVAVDRRPLPDDLESTSPPFTGSLREIRGDLNSLNLVDCLKNISTVFHLAALPGVRPSWTQFPEYLRCNVLATQRLMEACVQAGVERVVVASSSSVYGGADGVMSEDDLPRPLSPYGVTKLAAERLALAFAARGDAELSVGALRFFTVYGPGQRPDMFISRLIRATLRGEPVEIYGDGTQLRDFTHVSDVVRALMLTASVRDRGSAVLNIGTGSAVSVNEVVSMTAELTGLRPCTAYGSARIGDVRSTTADVRQAQSVLGFTARTGLREGLATQIEWTRRSLSGAEQDTVPVGGSSVSVPRL","length":340,"molWeight":36123,"crc64":"2186CFD513C4A3EB","md5":"EF135B36ED6ABC56048ACA673273E179"},"extraAttributes":{"countByFeatureType":{"Domain":1,"Region":1,"Compositional bias":1,"Binding site":38},"uniParcId":"UPI0000E5B23F"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0A005","uniProtkbId":"A0A005_STRVD","entryAudit":{"firstPublicDate":"2006-11-14","lastAnnotationUpdateDate":"2026-11-04","lastSequenceUpdateDate":"2006-11-14","entryVersion":31,"sequenceVersion":1},"annotationScore":1.0,"organism":{"scientificName":"Streptomyces viridosporus","taxonId":67581,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ABJ90158.1"}],"lineage":["Bacteria","Bacillati","Actinomycetota","Actinomycetes","Kitasatosporales","Streptomycetaceae","Streptomyces"]},"proteinExistence":"4: Predicted","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ABJ90158.1"}],"value":"MoeGT1"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ABJ90158.1"}],"value":"moeGT1"}}],"references":[{"referenceNumber":1,"citation":{"id":"CI-9LAJ522RF4IIS","citationType":"submission","authors":["Ostash B.O.","Walker S."],"publicationDate":"SEP-2006","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ABJ90158.1"}],"value":"ATCC14672","type":"STRAIN"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ABJ90158.1"}]},{"referenceNumber":2,"citation":{"id":"17379141","citationType":"journal article","authors":["Ostash B.","Saghatelian A.","Walker S."],"citationCrossReferences":[{"database":"PubMed","id":"17379141"},{"database":"DOI","id":"10.1016/j.chembiol.2007.01.008"}],"title":"A streamlined metabolic pathway for the biosynthesis of moenomycin A.","publicationDate":"2007","journal":"Chem. Biol.","firstPage":"257","lastPage":"267","volume":"14"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ABJ90158.1"}],"value":"ATCC14672","type":"STRAIN"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ABJ90158.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"DQ988994","properties":[{"key":"ProteinId","value":"ABJ90158.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"RefSeq","id":"WP_004981182.1","properties":[{"key":"NucleotideSequenceId","value":"NZ_JBEOYY010000017.1"}]},{"database":"AlphaFoldDB","id":"A0A005","properties":[{"key":"Description","value":"-"}]},{"database":"GeneID","id":"307735495","properties":[{"key":"Description","value":"-"}]},{"database":"Gene3D","id":"3.40.50.2000","properties":[{"key":"EntryName","value":"Glycogen Phosphorylase B"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR21015:SF22","properties":[{"key":"EntryName","value":"GLYCOSYLTRANSFERASE"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR21015","properties":[{"key":"EntryName","value":"UDP-N-ACETYLGLUCOSAMINE--N-ACETYLMURAMYL-(PENTAPEPTIDE) PYROPHOSPHORYL-UNDECAPRENOL N-ACETYLGLUCOSAMINE TRANSFERASE 1"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF53756","properties":[{"key":"EntryName","value":"UDP-Glycosyltransferase/glycogen phosphorylase"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MAAPDRPLVQVLSPRTWGEFGNYLAATRFSRALRSVIDAEVTLLEAEPILPWIGEAGAQIRTISLESPDAVVRNQRYMALMDRLQARFPEGFEADPTAAQRADLEPLTRHLRESAPDVVVGTKGFVARLCVAAVRLAGTSTRVVSHVTNPGLLQLPLHRSRYPDLTLVGFPRAKEHLLATAGGDPERVQVVGPLVAQHDLRDFMTSETAVSEAGPWGGDSGPDRPRVIIFSNRGGDTYPELVRRLADRHPGIDLVFVGYGDPELARRTAAVGRPHWRFHSVLGQSEYFDYIRRASRSRYGLLVSKAGPNTTLEAAYFGIPVLMLESGLPMERWVPGLIHEEGLGHACATPEELFRTADDWLTRPSVIEVHKKAAVSFAASVLDQDAVTARIKAALQPLLDAR","length":402,"molWeight":44120,"crc64":"AC0BE223F9977F6D","md5":"70FB828114484E1A85BBC7026F0D2A94"},"extraAttributes":{"uniParcId":"UPI0000E5B241"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0A006","uniProtkbId":"A0A006_STRVD","entryAudit":{"firstPublicDate":"2006-11-14","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2006-11-14","entryVersion":47,"sequenceVersion":1},"annotationScore":1.0,"organism":{"scientificName":"Streptomyces viridosporus","taxonId":67581,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ABJ90159.1"}],"lineage":["Bacteria","Bacillati","Actinomycetota","Actinomycetes","Kitasatosporales","Streptomycetaceae","Streptomyces"]},"proteinExistence":"4: Predicted","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00012737"}],"value":"asparagine synthase (glutamine-hydrolyzing)"},"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00012737"}],"value":"6.3.5.4"}]}},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ABJ90159.1"}],"value":"moeH5"}}],"comments":[{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"L-aspartate + L-glutamine + ATP + H2O = L-asparagine + L-glutamate + AMP + diphosphate + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:12228"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:29985"},{"database":"ChEBI","id":"CHEBI:29991"},{"database":"ChEBI","id":"CHEBI:30616"},{"database":"ChEBI","id":"CHEBI:33019"},{"database":"ChEBI","id":"CHEBI:58048"},{"database":"ChEBI","id":"CHEBI:58359"},{"database":"ChEBI","id":"CHEBI:456215"}],"ecNumber":"6.3.5.4","evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00048741"}]}},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00005187"}],"value":"Amino-acid biosynthesis; L-asparagine biosynthesis; L-asparagine from L-aspartate (L-Gln route): step 1/1"}],"commentType":"PATHWAY"}],"features":[{"type":"Domain","location":{"start":{"value":166,"modifier":"EXACT"},"end":{"value":412,"modifier":"EXACT"}},"description":"Asparagine synthetase","evidences":[{"evidenceCode":"ECO:0000259","source":"Pfam","id":"PF00733"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022888"}],"id":"KW-0028","category":"Biological process","name":"Amino-acid biosynthesis"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022888"}],"id":"KW-0061","category":"Biological process","name":"Asparagine biosynthesis"}],"references":[{"referenceNumber":1,"citation":{"id":"CI-9LAJ522RF4IIS","citationType":"submission","authors":["Ostash B.O.","Walker S."],"publicationDate":"SEP-2006","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ABJ90159.1"}],"value":"ATCC14672","type":"STRAIN"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ABJ90159.1"}]},{"referenceNumber":2,"citation":{"id":"17379141","citationType":"journal article","authors":["Ostash B.","Saghatelian A.","Walker S."],"citationCrossReferences":[{"database":"PubMed","id":"17379141"},{"database":"DOI","id":"10.1016/j.chembiol.2007.01.008"}],"title":"A streamlined metabolic pathway for the biosynthesis of moenomycin A.","publicationDate":"2007","journal":"Chem. Biol.","firstPage":"257","lastPage":"267","volume":"14"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ABJ90159.1"}],"value":"ATCC14672","type":"STRAIN"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ABJ90159.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"DQ988994","properties":[{"key":"ProteinId","value":"ABJ90159.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"RefSeq","id":"WP_016823893.1","properties":[{"key":"NucleotideSequenceId","value":"NZ_JBEYYS010000013.1"}]},{"database":"AlphaFoldDB","id":"A0A006","properties":[{"key":"Description","value":"-"}]},{"database":"GeneID","id":"307735494","properties":[{"key":"Description","value":"-"}]},{"database":"GO","id":"GO:0004066","properties":[{"key":"GoTerm","value":"F:asparagine synthase (glutamine-hydrolyzing) activity"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-EC"}]},{"database":"Gene3D","id":"3.60.20.10","properties":[{"key":"EntryName","value":"Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.40.50.620","properties":[{"key":"EntryName","value":"HUPs"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR001962","properties":[{"key":"EntryName","value":"Asn_synthase"}]},{"database":"InterPro","id":"IPR051786","properties":[{"key":"EntryName","value":"ASN_synthetase/amidase"}]},{"database":"InterPro","id":"IPR029055","properties":[{"key":"EntryName","value":"Ntn_hydrolases_N"}]},{"database":"InterPro","id":"IPR014729","properties":[{"key":"EntryName","value":"Rossmann-like_a/b/a_fold"}]},{"database":"PANTHER","id":"PTHR43284:SF1","properties":[{"key":"EntryName","value":"ASPARAGINE SYNTHETASE"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR43284","properties":[{"key":"EntryName","value":"ASPARAGINE SYNTHETASE (GLUTAMINE-HYDROLYZING)"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00733","properties":[{"key":"EntryName","value":"Asn_synthase"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF13522","properties":[{"key":"EntryName","value":"GATase_6"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF52402","properties":[{"key":"EntryName","value":"Adenine nucleotide alpha hydrolases-like"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF56235","properties":[{"key":"EntryName","value":"N-terminal nucleophile aminohydrolases (Ntn hydrolases)"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MTVRRPAASAPRVLLTAGPDGVRVEGDGEARLGHPLTGDHLDPGPPAEGVFAGWRWDGERLVARNDRYGVCPLFYRAGGGSLALSPDPLALLPEDGPVELDHDALAVFLRTGFFLAEDTAFAQVRALPPAATLTWDTGGLRLRSDGPPRPGAAAMTEAQAVDGFVDLFRASVARRLPGEPYDLPLSGGRDSRHILLELCRRGAPPRRCVSGAKFPPDPGADARVAAALAGRLGLPHTVVPRPRSQFRAELAALPAQGMTTLDGAWTQPVLAHLRRHSRISYDGLGGGELVQNPSVEFIRANPYDPADLPGLADRLLAASRTGPHVEHLLSPRTNALWSRQAARRRLVTELARHADSASPLSSFFFWNRTRRSISAAPFALGDGRVLTHTPYLDHALFDHLASVPHRFLVDGTFHDRALHRAFPEHADLGFASSVPQRHGPVLVAHRLAYLLRFLAHATVVEPGWWRGPDRFLQRLLAAGRGPGAPQRVSRLQPLALYLLQLEDLAVRRARRRP","length":513,"molWeight":55801,"crc64":"72748808290D48FD","md5":"8928F608E220A66126E56E675B323838"},"extraAttributes":{"countByCommentType":{"CATALYTIC ACTIVITY":1,"PATHWAY":1},"countByFeatureType":{"Domain":1},"uniParcId":"UPI0000E5B242"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0A007","uniProtkbId":"A0A007_STRVD","entryAudit":{"firstPublicDate":"2006-11-14","lastAnnotationUpdateDate":"2026-11-04","lastSequenceUpdateDate":"2006-11-14","entryVersion":69,"sequenceVersion":1},"annotationScore":1.0,"organism":{"scientificName":"Streptomyces viridosporus","taxonId":67581,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ABJ90160.1"}],"lineage":["Bacteria","Bacillati","Actinomycetota","Actinomycetes","Kitasatosporales","Streptomycetaceae","Streptomyces"]},"proteinExistence":"4: Predicted","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ABJ90160.1"}],"value":"MoeK5"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ABJ90160.1"}],"value":"moeK5"}}],"comments":[{"commentType":"COFACTOR","cofactors":[{"name":"[4Fe-4S] cluster","evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00001966"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU01266"}],"cofactorCrossReference":{"database":"ChEBI","id":"CHEBI:49883"}}]}],"features":[{"type":"Domain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":115,"modifier":"EXACT"}},"description":"B12-binding","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS51332"}]},{"type":"Domain","location":{"start":{"value":155,"modifier":"EXACT"},"end":{"value":374,"modifier":"EXACT"}},"description":"Radical SAM core","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS51918"}]},{"type":"Region","location":{"start":{"value":368,"modifier":"EXACT"},"end":{"value":395,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Binding site","location":{"start":{"value":169,"modifier":"EXACT"},"end":{"value":169,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:49883"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU01266"}],"ligand":{"name":"[4Fe-4S] cluster","id":"ChEBI:CHEBI:49883","note":"4Fe-4S-S-AdoMet"}},{"type":"Binding site","location":{"start":{"value":173,"modifier":"EXACT"},"end":{"value":173,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:49883"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU01266"}],"ligand":{"name":"[4Fe-4S] cluster","id":"ChEBI:CHEBI:49883","note":"4Fe-4S-S-AdoMet"}},{"type":"Binding site","location":{"start":{"value":176,"modifier":"EXACT"},"end":{"value":176,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:49883"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU01266"}],"ligand":{"name":"[4Fe-4S] cluster","id":"ChEBI:CHEBI:49883","note":"4Fe-4S-S-AdoMet"}}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022485"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU01266"}],"id":"KW-0004","category":"Ligand","name":"4Fe-4S"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022628"}],"id":"KW-0846","category":"Ligand","name":"Cobalamin"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023285"}],"id":"KW-0170","category":"Ligand","name":"Cobalt"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023004"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU01266"}],"id":"KW-0408","category":"Ligand","name":"Iron"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023014"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU01266"}],"id":"KW-0411","category":"Ligand","name":"Iron-sulfur"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022723"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU01266"}],"id":"KW-0479","category":"Ligand","name":"Metal-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022691"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU01266"}],"id":"KW-0949","category":"Ligand","name":"S-adenosyl-L-methionine"}],"references":[{"referenceNumber":1,"citation":{"id":"CI-9LAJ522RF4IIS","citationType":"submission","authors":["Ostash B.O.","Walker S."],"publicationDate":"SEP-2006","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ABJ90160.1"}],"value":"ATCC14672","type":"STRAIN"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ABJ90160.1"}]},{"referenceNumber":2,"citation":{"id":"17379141","citationType":"journal article","authors":["Ostash B.","Saghatelian A.","Walker S."],"citationCrossReferences":[{"database":"PubMed","id":"17379141"},{"database":"DOI","id":"10.1016/j.chembiol.2007.01.008"}],"title":"A streamlined metabolic pathway for the biosynthesis of moenomycin A.","publicationDate":"2007","journal":"Chem. Biol.","firstPage":"257","lastPage":"267","volume":"14"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ABJ90160.1"}],"value":"ATCC14672","type":"STRAIN"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ABJ90160.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"DQ988994","properties":[{"key":"ProteinId","value":"ABJ90160.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"AlphaFoldDB","id":"A0A007","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"A0A007","properties":[{"key":"Description","value":"-"}]},{"database":"GO","id":"GO:0005829","properties":[{"key":"GoTerm","value":"C:cytosol"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:0051539","properties":[{"key":"GoTerm","value":"F:4 iron, 4 sulfur cluster binding"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniRule"}]},{"database":"GO","id":"GO:0003824","properties":[{"key":"GoTerm","value":"F:catalytic activity"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0031419","properties":[{"key":"GoTerm","value":"F:cobalamin binding"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0046872","properties":[{"key":"GoTerm","value":"F:metal ion binding"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniRule"}]},{"database":"CDD","id":"cd01335","properties":[{"key":"EntryName","value":"Radical_SAM"},{"key":"MatchStatus","value":"1"}]},{"database":"CDD","id":"cd02068","properties":[{"key":"EntryName","value":"radical_SAM_B12_BD"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.40.50.280","properties":[{"key":"EntryName","value":"Cobalamin-binding domain"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.80.30.20","properties":[{"key":"EntryName","value":"tm_1862 like domain"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR051198","properties":[{"key":"EntryName","value":"BchE-like"}]},{"database":"InterPro","id":"IPR006158","properties":[{"key":"EntryName","value":"Cobalamin-bd"}]},{"database":"InterPro","id":"IPR006638","properties":[{"key":"EntryName","value":"Elp3/MiaA/NifB-like_rSAM"}]},{"database":"InterPro","id":"IPR034466","properties":[{"key":"EntryName","value":"Methyltransferase_Class_B"}]},{"database":"InterPro","id":"IPR007197","properties":[{"key":"EntryName","value":"rSAM"}]},{"database":"InterPro","id":"IPR023404","properties":[{"key":"EntryName","value":"rSAM_horseshoe"}]},{"database":"InterPro","id":"IPR058240","properties":[{"key":"EntryName","value":"rSAM_sf"}]},{"database":"PANTHER","id":"PTHR43409","properties":[{"key":"EntryName","value":"ANAEROBIC MAGNESIUM-PROTOPORPHYRIN IX MONOMETHYL ESTER CYCLASE-RELATED"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR43409:SF16","properties":[{"key":"EntryName","value":"SLR0320 PROTEIN"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF02310","properties":[{"key":"EntryName","value":"B12-binding"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF04055","properties":[{"key":"EntryName","value":"Radical_SAM"},{"key":"MatchStatus","value":"1"}]},{"database":"SFLD","id":"SFLDG01082","properties":[{"key":"EntryName","value":"B12-binding_domain_containing"},{"key":"MatchStatus","value":"1"}]},{"database":"SFLD","id":"SFLDG01123","properties":[{"key":"EntryName","value":"methyltransferase_(Class_B)"},{"key":"MatchStatus","value":"1"}]},{"database":"SFLD","id":"SFLDS00029","properties":[{"key":"EntryName","value":"Radical_SAM"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00729","properties":[{"key":"EntryName","value":"Elp3"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF102114","properties":[{"key":"EntryName","value":"Radical SAM enzymes"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS51332","properties":[{"key":"EntryName","value":"B12_BINDING"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS51918","properties":[{"key":"EntryName","value":"RADICAL_SAM"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MGYIHTALKSAGFHHVIQVDTPALGLDSEGLRKLLADFEPDLVGVSTTTPGLPGAIEACEAAKSTGAKVILGGPHTEVYAHENLVHESIDYVGVGEGVTIMPELAEAMERGEEPEGIRGLVTRKHDGGAAPMVNLEEVGWPERAGLPMDRYYSIMAPRPFATMISSRGCPFKCSFCFKQAVDKKSMYRSPEDVVGEMTELKERWGVKEIMFYDDVFTLHRGRVREICGLIGETGLKVRWEAPTRVDLVPEPLLEAMAGAGCVRLRFGIEHGDSEILERMRKESDIQKIEKAVTSAHEAGIKGFGYFIVGWLGETREQFRRTVDLACRLPLDYASFYTATPLPGTPLHTESVAAGQIPPDYWDRFSCGASSTRGSGTWCRTRRSAPSGRTAPSSCAAPWSSRCCRTWR","length":407,"molWeight":44731,"crc64":"5AC984E6BA2EA778","md5":"7B046718BA42397C853947225B5A04D8"},"extraAttributes":{"countByCommentType":{"COFACTOR":1},"countByFeatureType":{"Domain":2,"Region":1,"Binding site":3},"uniParcId":"UPI0000E5B243"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0A008","uniProtkbId":"A0A008_STRVD","entryAudit":{"firstPublicDate":"2006-11-14","lastAnnotationUpdateDate":"2026-11-04","lastSequenceUpdateDate":"2006-11-14","entryVersion":33,"sequenceVersion":1},"annotationScore":1.0,"organism":{"scientificName":"Streptomyces viridosporus","taxonId":67581,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ABJ90161.1"}],"lineage":["Bacteria","Bacillati","Actinomycetota","Actinomycetes","Kitasatosporales","Streptomycetaceae","Streptomyces"]},"proteinExistence":"4: Predicted","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ABJ90161.1"}],"value":"MoeGT4"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ABJ90161.1"}],"value":"moeGT4"}}],"features":[{"type":"Region","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":37,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":8,"modifier":"EXACT"},"end":{"value":20,"modifier":"EXACT"}},"description":"Pro residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]}],"references":[{"referenceNumber":1,"citation":{"id":"CI-9LAJ522RF4IIS","citationType":"submission","authors":["Ostash B.O.","Walker S."],"publicationDate":"SEP-2006","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ABJ90161.1"}],"value":"ATCC14672","type":"STRAIN"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ABJ90161.1"}]},{"referenceNumber":2,"citation":{"id":"17379141","citationType":"journal article","authors":["Ostash B.","Saghatelian A.","Walker S."],"citationCrossReferences":[{"database":"PubMed","id":"17379141"},{"database":"DOI","id":"10.1016/j.chembiol.2007.01.008"}],"title":"A streamlined metabolic pathway for the biosynthesis of moenomycin A.","publicationDate":"2007","journal":"Chem. Biol.","firstPage":"257","lastPage":"267","volume":"14"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ABJ90161.1"}],"value":"ATCC14672","type":"STRAIN"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ABJ90161.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"DQ988994","properties":[{"key":"ProteinId","value":"ABJ90161.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"AlphaFoldDB","id":"A0A008","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"AICHYYV","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"InterPro","id":"IPR029044","properties":[{"key":"EntryName","value":"Nucleotide-diphossugar_trans"}]},{"database":"SUPFAM","id":"SSF53448","properties":[{"key":"EntryName","value":"Nucleotide-diphospho-sugar transferases"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MTSEPAAPAVPHPPVRPGPPVRLNRPLARRRRRPAGEGFVTHHLRSTMARGFRPPESWEVPVRHVLPGLPADGTPRAEEAAQALRTPAGRPGIALVVPTYVSRVSLARQREWFDALLDQAAAVTRDHPLVPLVLFVGMQWSSAEEEREALRRLRVLLDDARTRLPGLRICGLALPGPGKPRTLNGAIAVAELLGCAGVGWTDDDVTLEEDCLSRLVRDFLAAGCRGAVGATKVAHTHEYATSRLLSRAKAIAAPATNYPHGCCILVATDVVAGGLPGRYVSDDGYVCFRLLDPALPDPLARLRLVPDARCHYYVAGPAGETRRRIRRLLLNHLVDLADWPLPVVRHYFRHVLFGGMWPLTGFDSSRGARRGVQKALIKWLYFAWFAGIGGELYVRGLSGRPLRRIEWAPYSDIRRLTPSSSPTRQES","length":427,"molWeight":46985,"crc64":"B4CF4DF9B01E6A7D","md5":"778231FDC2BF97820426FB877A4A600C"},"extraAttributes":{"countByFeatureType":{"Region":1,"Compositional bias":1},"uniParcId":"UPI0000E5B244"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0A009","uniProtkbId":"A0A009_STRVD","entryAudit":{"firstPublicDate":"2006-11-14","lastAnnotationUpdateDate":"2026-11-04","lastSequenceUpdateDate":"2006-11-14","entryVersion":44,"sequenceVersion":1},"annotationScore":1.0,"organism":{"scientificName":"Streptomyces viridosporus","taxonId":67581,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ABJ90162.1"}],"lineage":["Bacteria","Bacillati","Actinomycetota","Actinomycetes","Kitasatosporales","Streptomycetaceae","Streptomyces"]},"proteinExistence":"3: Inferred from homology","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ABJ90162.1"}],"value":"MoeM5"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ABJ90162.1"}],"value":"moeM5"}}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00006129"}],"value":"Belongs to the NodU/CmcH family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Domain","location":{"start":{"value":6,"modifier":"EXACT"},"end":{"value":61,"modifier":"EXACT"}},"description":"Carbamoyltransferase","evidences":[{"evidenceCode":"ECO:0000259","source":"Pfam","id":"PF02543"}]},{"type":"Domain","location":{"start":{"value":105,"modifier":"EXACT"},"end":{"value":312,"modifier":"EXACT"}},"description":"Carbamoyltransferase","evidences":[{"evidenceCode":"ECO:0000259","source":"Pfam","id":"PF02543"}]},{"type":"Domain","location":{"start":{"value":362,"modifier":"EXACT"},"end":{"value":525,"modifier":"EXACT"}},"description":"Carbamoyltransferase C-terminal","evidences":[{"evidenceCode":"ECO:0000259","source":"Pfam","id":"PF16861"}]}],"references":[{"referenceNumber":1,"citation":{"id":"CI-9LAJ522RF4IIS","citationType":"submission","authors":["Ostash B.O.","Walker S."],"publicationDate":"SEP-2006","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ABJ90162.1"}],"value":"ATCC14672","type":"STRAIN"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ABJ90162.1"}]},{"referenceNumber":2,"citation":{"id":"17379141","citationType":"journal article","authors":["Ostash B.","Saghatelian A.","Walker S."],"citationCrossReferences":[{"database":"PubMed","id":"17379141"},{"database":"DOI","id":"10.1016/j.chembiol.2007.01.008"}],"title":"A streamlined metabolic pathway for the biosynthesis of moenomycin A.","publicationDate":"2007","journal":"Chem. Biol.","firstPage":"257","lastPage":"267","volume":"14"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ABJ90162.1"}],"value":"ATCC14672","type":"STRAIN"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ABJ90162.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"DQ988994","properties":[{"key":"ProteinId","value":"ABJ90162.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"RefSeq","id":"WP_004981190.1","properties":[{"key":"NucleotideSequenceId","value":"NZ_JBVHKF010000018.1"}]},{"database":"AlphaFoldDB","id":"A0A009","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"A0A009","properties":[{"key":"Description","value":"-"}]},{"database":"GeneID","id":"307735491","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"AFHTQHD","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"GO","id":"GO:0003824","properties":[{"key":"GoTerm","value":"F:catalytic activity"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"CDD","id":"cd24033","properties":[{"key":"EntryName","value":"ASKHA_NBD_NodU_CmcH-like_N"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.30.420.40","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"2"}]},{"database":"Gene3D","id":"3.90.870.20","properties":[{"key":"EntryName","value":"Carbamoyltransferase, C-terminal domain"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR043129","properties":[{"key":"EntryName","value":"ATPase_NBD"}]},{"database":"InterPro","id":"IPR031730","properties":[{"key":"EntryName","value":"Carbam_trans_C"}]},{"database":"InterPro","id":"IPR038152","properties":[{"key":"EntryName","value":"Carbam_trans_C_sf"}]},{"database":"InterPro","id":"IPR003696","properties":[{"key":"EntryName","value":"Carbtransf_dom"}]},{"database":"InterPro","id":"IPR051338","properties":[{"key":"EntryName","value":"NodU/CmcH_Carbamoyltrnsfr"}]},{"database":"PANTHER","id":"PTHR34847","properties":[{"key":"EntryName","value":"NODULATION PROTEIN U"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR34847:SF1","properties":[{"key":"EntryName","value":"NODULATION PROTEIN U"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF16861","properties":[{"key":"EntryName","value":"Carbam_trans_C"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF02543","properties":[{"key":"EntryName","value":"Carbam_trans_N"},{"key":"MatchStatus","value":"2"}]},{"database":"SUPFAM","id":"SSF53067","properties":[{"key":"EntryName","value":"Actin-like ATPase domain"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MKVLSLHSAGHDTGVAYFEDGRLVFAVETERLTRVKHDHRSDVALRHVLEQECVDTDGIDLVAVSTPVRSGLLRIPDLDRAMERIGAGALHHRTVCEMLGRRVECVVVTHEVSHAALAAHYADWEEGTVVLVNEGRGQLTRSSLFRVTGGALEWVDKDPLPWYGNGFGWTAIGYLLGFGPSPSVAGKVMAMGGYGQPDPRIREQLLSVDPEVMNDRELAERVRADLAGRPEFAPGFETASQVVATFQEMFTEAVRAVLDRHVTRTDAGVGPIALGGGCALNIVANSALREEYGRDVAIPPACGDAGHLTGAGLYALAQVAGVKPEPFSVYRNGGGEARAAVLEAVEGAGLRAVPYDRSAVAGVLAGGGVVALTQGAAELGPRALGHRSLLGSPAVPGMRERMSEKLKRREWFRPLGAVMRDERFAGLYPGRAPSPYMLFEYRLPDGIAPEARHVNGTCRIQTLGPEEDRLYGLLAEFEELSGVPALINTSLNGPGKPIAHTARDVLDDFARTDVDLFVFDDLMVRGAAAR","length":530,"molWeight":56948,"crc64":"AA3D2FB934A14063","md5":"695874738BEAE14A6270A2C4A26AFB8A"},"extraAttributes":{"countByCommentType":{"SIMILARITY":1},"countByFeatureType":{"Domain":3},"uniParcId":"UPI0000E5B245"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0A010","uniProtkbId":"A0A010_STRVD","entryAudit":{"firstPublicDate":"2006-11-14","lastAnnotationUpdateDate":"2026-11-04","lastSequenceUpdateDate":"2006-11-14","entryVersion":35,"sequenceVersion":1},"annotationScore":1.0,"organism":{"scientificName":"Streptomyces viridosporus","taxonId":67581,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ABJ90163.1"}],"lineage":["Bacteria","Bacillati","Actinomycetota","Actinomycetes","Kitasatosporales","Streptomycetaceae","Streptomyces"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ABJ90163.1"}],"value":"MoeN5"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ABJ90163.1"}],"value":"moeN5"}}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5B00"},{"evidenceCode":"ECO:0007829","source":"PDB","id":"5B01"}],"id":"KW-0002","category":"Technical term","name":"3D-structure"}],"references":[{"referenceNumber":1,"citation":{"id":"CI-9LAJ522RF4IIS","citationType":"submission","authors":["Ostash B.O.","Walker S."],"publicationDate":"SEP-2006","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ABJ90163.1"}],"value":"ATCC14672","type":"STRAIN"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ABJ90163.1"}]},{"referenceNumber":2,"citation":{"id":"17379141","citationType":"journal article","authors":["Ostash B.","Saghatelian A.","Walker S."],"citationCrossReferences":[{"database":"PubMed","id":"17379141"},{"database":"DOI","id":"10.1016/j.chembiol.2007.01.008"}],"title":"A streamlined metabolic pathway for the biosynthesis of moenomycin A.","publicationDate":"2007","journal":"Chem. Biol.","firstPage":"257","lastPage":"267","volume":"14"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ABJ90163.1"}],"value":"ATCC14672","type":"STRAIN"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ABJ90163.1"}]},{"referenceNumber":3,"citation":{"id":"CI-CRBP75AII5T54","citationType":"submission","authors":["Zhang L.","Chen C.-C.","Ko T.-P.","Guo R.-T.","Oldfield E.O."],"title":"Structure and function of a prenyltransferase.","publicationDate":"OCT-2015","submissionDatabase":"PDB data bank"},"referencePositions":["X-RAY CRYSTALLOGRAPHY (3.45 ANGSTROMS)"],"evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5B01"}]},{"referenceNumber":4,"citation":{"id":"26954060","citationType":"journal article","authors":["Zhang L.","Chen C.C.","Ko T.P.","Huang J.W.","Zheng Y.","Liu W.","Wang I.","Malwal S.R.","Feng X.","Wang K.","Huang C.H.","Hsu S.T.","Wang A.H.","Oldfield E.","Guo R.T."],"citationCrossReferences":[{"database":"PubMed","id":"26954060"},{"database":"DOI","id":"10.1002/anie.201511388"}],"title":"Moenomycin Biosynthesis: Structure and Mechanism of Action of the Prenyltransferase MoeN5.","publicationDate":"2016","journal":"Angew. Chem. Int. Ed.","firstPage":"4716","lastPage":"4720","volume":"55"},"referencePositions":["X-RAY CRYSTALLOGRAPHY (2.21 ANGSTROMS)"],"evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5B00"},{"evidenceCode":"ECO:0007829","source":"PDB","id":"5B02"}]},{"referenceNumber":5,"citation":{"id":"30837154","citationType":"journal article","authors":["Zhang L.","Ko T.P.","Malwal S.R.","Liu W.","Zhou S.","Yu X.","Oldfield E.","Guo R.T.","Chen C.C."],"citationCrossReferences":[{"database":"PubMed","id":"30837154"},{"database":"DOI","id":"10.1016/j.bbrc.2019.02.131"}],"title":"Complex structures of MoeN5 with substrate analogues suggest sequential catalytic mechanism.","publicationDate":"2019","journal":"Biochem. Biophys. Res. Commun.","firstPage":"800","lastPage":"805","volume":"511"},"referencePositions":["X-RAY CRYSTALLOGRAPHY (2.23 ANGSTROMS)"],"evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5GWV"},{"evidenceCode":"ECO:0007829","source":"PDB","id":"5GWW"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"DQ988994","properties":[{"key":"ProteinId","value":"ABJ90163.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"PDB","id":"5B00","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.95 A"},{"key":"Chains","value":"A/B/C=1-260"}]},{"database":"PDB","id":"5B01","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"3.45 A"},{"key":"Chains","value":"A/B/C/D/E/F/G/H/I/J=1-260"}]},{"database":"PDB","id":"5B02","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.21 A"},{"key":"Chains","value":"A/B/C/D=1-260"}]},{"database":"PDB","id":"5B03","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.60 A"},{"key":"Chains","value":"A/B/C/D=1-260"}]},{"database":"PDB","id":"5B0I","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.26 A"},{"key":"Chains","value":"A/B/C/D=1-260"}]},{"database":"PDB","id":"5B0J","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.50 A"},{"key":"Chains","value":"A/B/C/D=1-260"}]},{"database":"PDB","id":"5B0K","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.75 A"},{"key":"Chains","value":"A/B/C/D=1-260"}]},{"database":"PDB","id":"5B0L","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.80 A"},{"key":"Chains","value":"A/B/C/D/E/F/G/H=1-260"}]},{"database":"PDB","id":"5B0M","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"3.05 A"},{"key":"Chains","value":"A/B/C/D/E/F/G/H=1-260"}]},{"database":"PDB","id":"5GWV","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.40 A"},{"key":"Chains","value":"A/B/C/D=1-260"}]},{"database":"PDB","id":"5GWW","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.30 A"},{"key":"Chains","value":"A/B/C/D=1-260"}]},{"database":"PDB","id":"6J8V","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.23 A"},{"key":"Chains","value":"A/B/C/D=1-260"}]},{"database":"PDB","id":"6J8W","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.35 A"},{"key":"Chains","value":"A/B/C/D=1-260"}]},{"database":"AlphaFoldDB","id":"A0A010","properties":[{"key":"Description","value":"-"}]},{"database":"MDposit","id":"A0A010","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"A0A010","properties":[{"key":"Description","value":"-"}]},{"database":"EvolutionaryTrace","id":"A0A010","properties":[{"key":"Description","value":"-"}]},{"database":"Gene3D","id":"1.10.600.10","properties":[{"key":"EntryName","value":"Farnesyl Diphosphate Synthase"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR008949","properties":[{"key":"EntryName","value":"Isoprenoid_synthase_dom_sf"}]}],"sequence":{"value":"MLAAEAANRDHVTRCVAQTGGSPDLVAHTAALRLYLRVPHFLTEWTTDPDRRAAVSRALALDIVSMKLLDDLMDDDTGLDRVELACVCLRLHLRALHELESLARDPKAVTDILEQDAVHLCGGQIRTKRSRATNLREWRAHASTYGSTFLGRYGALAAACGGEGQPADSVREFAEAFAMTITMADDLTDYDRNGERDGNLAHLMRTGAVAGQDVVDLLEELRGRALAAVAAPPGAPGLVPVVHLYTDDVLVRLLPRHLGE","length":260,"molWeight":28219,"crc64":"92B006C2CA7EB133","md5":"D0286A9A93BC205CDFE180555818E8E8"},"extraAttributes":{"uniParcId":"UPI0000E5B246"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0A011","uniProtkbId":"A0A011_STRVD","entryAudit":{"firstPublicDate":"2006-11-14","lastAnnotationUpdateDate":"2026-11-04","lastSequenceUpdateDate":"2006-11-14","entryVersion":58,"sequenceVersion":1},"annotationScore":1.0,"organism":{"scientificName":"Streptomyces viridosporus","taxonId":67581,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ABJ90164.1"}],"lineage":["Bacteria","Bacillati","Actinomycetota","Actinomycetes","Kitasatosporales","Streptomycetaceae","Streptomyces"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ABJ90164.1"}],"value":"MoeO5"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ABJ90164.1"}],"value":"moeO5"}}],"comments":[{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"sn-glycerol 1-phosphate + all-trans-heptaprenyl diphosphate = 3-heptaprenyl-sn-glycero-1-phosphate + diphosphate","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:33495"},{"database":"ChEBI","id":"CHEBI:33019"},{"database":"ChEBI","id":"CHEBI:57685"},{"database":"ChEBI","id":"CHEBI:58206"},{"database":"ChEBI","id":"CHEBI:64781"}],"ecNumber":"2.5.1.n9","evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00048318"}]}}],"features":[{"type":"Binding site","location":{"start":{"value":41,"modifier":"EXACT"},"end":{"value":41,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:18420"}],"evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"3VKB"},{"evidenceCode":"ECO:0007829","source":"PDB","id":"3VKD"}],"ligand":{"name":"Mg(2+)","id":"ChEBI:CHEBI:18420","label":"1"}},{"type":"Binding site","location":{"start":{"value":69,"modifier":"EXACT"},"end":{"value":69,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:18420"}],"evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"3VKB"},{"evidenceCode":"ECO:0007829","source":"PDB","id":"3VKD"}],"ligand":{"name":"Mg(2+)","id":"ChEBI:CHEBI:18420","label":"1"}},{"type":"Binding site","location":{"start":{"value":71,"modifier":"EXACT"},"end":{"value":71,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:18420"}],"evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"3VKD"}],"ligand":{"name":"Mg(2+)","id":"ChEBI:CHEBI:18420","label":"1"}},{"type":"Binding site","location":{"start":{"value":137,"modifier":"EXACT"},"end":{"value":137,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:18420"}],"evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"3VK5"},{"evidenceCode":"ECO:0007829","source":"PDB","id":"3VKA"}],"ligand":{"name":"Mg(2+)","id":"ChEBI:CHEBI:18420","label":"2"}},{"type":"Binding site","location":{"start":{"value":138,"modifier":"EXACT"},"end":{"value":138,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:18420"}],"evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"3VK5"},{"evidenceCode":"ECO:0007829","source":"PDB","id":"3VKA"}],"ligand":{"name":"Mg(2+)","id":"ChEBI:CHEBI:18420","label":"2"}},{"type":"Binding site","location":{"start":{"value":140,"modifier":"EXACT"},"end":{"value":140,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:18420"}],"evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"3VK5"},{"evidenceCode":"ECO:0007829","source":"PDB","id":"3VKA"}],"ligand":{"name":"Mg(2+)","id":"ChEBI:CHEBI:18420","label":"2"}}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"3VK5"},{"evidenceCode":"ECO:0007829","source":"PDB","id":"3VKA"}],"id":"KW-0002","category":"Technical term","name":"3D-structure"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022516"}],"id":"KW-0444","category":"Biological process","name":"Lipid biosynthesis"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023098"}],"id":"KW-0443","category":"Biological process","name":"Lipid metabolism"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022842"}],"id":"KW-0460","category":"Ligand","name":"Magnesium"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022723"},{"evidenceCode":"ECO:0007829","source":"PDB","id":"3VK5"}],"id":"KW-0479","category":"Ligand","name":"Metal-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023209"}],"id":"KW-0594","category":"Biological process","name":"Phospholipid biosynthesis"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023264"}],"id":"KW-1208","category":"Biological process","name":"Phospholipid metabolism"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022679"}],"id":"KW-0808","category":"Molecular function","name":"Transferase"}],"references":[{"referenceNumber":1,"citation":{"id":"CI-1B4G30P4TTMDQ","citationType":"submission","authoringGroup":["The Broad Institute Genome Sequencing Platform"],"authors":["Birren B.","Lander E.","Galagan J.","Devon K.","Nusbaum C.","Borowsky M.L.","Jaffe D.","Butler J.","Alvarez P.","Gnerre S.","Grabherr M.","Kleber M.","Mauceli E.","Brockman W.","Rounsley S.","Young S.","LaButti K.","Pushparaj V.","DeCaprio D.","Crawford M.","Koehrsen M.","Engels R.","Montgomery P.","Pearson M.","Howarth C.","Zeng Q.","Kodira C.","Yandava C.","O'Leary S.","Alvarado L.","Murray M.","Kreiswirth B."],"publicationDate":"SEP-2006","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ABJ90164.1"}],"value":"ATCC14672","type":"STRAIN"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ABJ90164.1"}]},{"referenceNumber":2,"citation":{"id":"17379141","citationType":"journal article","authors":["Ostash B.","Saghatelian A.","Walker S."],"citationCrossReferences":[{"database":"PubMed","id":"17379141"},{"database":"DOI","id":"10.1016/j.chembiol.2007.01.008"}],"title":"A streamlined metabolic pathway for the biosynthesis of moenomycin A.","publicationDate":"2007","journal":"Chem. Biol.","firstPage":"257","lastPage":"267","volume":"14"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ABJ90164.1"}],"value":"ATCC14672","type":"STRAIN"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ABJ90164.1"}]},{"referenceNumber":3,"citation":{"id":"22431288","citationType":"journal article","authors":["Ren F.","Ko T.P.","Feng X.","Huang C.H.","Chan H.C.","Hu Y.","Wang K.","Ma Y.","Liang P.H.","Wang A.H.","Oldfield E.","Guo R.T."],"citationCrossReferences":[{"database":"PubMed","id":"22431288"},{"database":"DOI","id":"10.1002/anie.201108002"}],"title":"Insights into the mechanism of the antibiotic-synthesizing enzyme MoeO5 from crystal structures of different complexes.","publicationDate":"2012","journal":"Angew. Chem. Int. Ed.","firstPage":"4157","lastPage":"4160","volume":"51"},"referencePositions":["X-RAY CRYSTALLOGRAPHY (1.39 ANGSTROMS) IN COMPLEX WITH MG(2+)"],"evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"3VK5"},{"evidenceCode":"ECO:0007829","source":"PDB","id":"3VKA"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"DQ988994","properties":[{"key":"ProteinId","value":"ABJ90164.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"RefSeq","id":"WP_016823898.1","properties":[{"key":"NucleotideSequenceId","value":"NZ_JBEYYS010000013.1"}]},{"database":"PDB","id":"3VK5","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.39 A"},{"key":"Chains","value":"A/B=1-281"}]},{"database":"PDB","id":"3VKA","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.57 A"},{"key":"Chains","value":"A/B=1-281"}]},{"database":"PDB","id":"3VKB","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.80 A"},{"key":"Chains","value":"A/B=1-281"}]},{"database":"PDB","id":"3VKC","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.66 A"},{"key":"Chains","value":"A/B=1-281"}]},{"database":"PDB","id":"3VKD","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.66 A"},{"key":"Chains","value":"A/B=1-281"}]},{"database":"AlphaFoldDB","id":"A0A011","properties":[{"key":"Description","value":"-"}]},{"database":"MDposit","id":"A0A011","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"A0A011","properties":[{"key":"Description","value":"-"}]},{"database":"GeneID","id":"307735489","properties":[{"key":"Description","value":"-"}]},{"database":"EvolutionaryTrace","id":"A0A011","properties":[{"key":"Description","value":"-"}]},{"database":"GO","id":"GO:0016765","properties":[{"key":"GoTerm","value":"F:transferase activity, transferring alkyl or aryl (other than methyl) groups"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"CDD","id":"cd02812","properties":[{"key":"EntryName","value":"PcrB_like"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.20.20.390","properties":[{"key":"EntryName","value":"FMN-linked oxidoreductases"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR038597","properties":[{"key":"EntryName","value":"GGGP/HepGP_synthase_sf"}]},{"database":"InterPro","id":"IPR008205","properties":[{"key":"EntryName","value":"GGGP_HepGP_synthase"}]},{"database":"Pfam","id":"PF01884","properties":[{"key":"EntryName","value":"PcrB"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF51395","properties":[{"key":"EntryName","value":"FMN-linked oxidoreductases"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MNASPQLDHHTELHAAPPLWRPGRVLARLREHQPGPVHIIDPFKVPVTEAVEKAAELTRLGFAAVLLASTDYESFESHMEPYVAAVKAATPLPVVLHFPPRPGAGFPVVRGADALLLPALLGSGDDYFVWKSFLETLAAFPGRIPREEWPELLLTVALTFGEDPRTGDLLGTVPVSTASTEEIDRYLHVARAFGFHMVYLYSRNEHVPPEVVRHFRKGLGPDQVLFVSGNVRSGRQVTEYLDSGADYVGFAGALEQPDWRSALAEIAGRRPAAPARPGSGR","length":281,"molWeight":30731,"crc64":"8B27209EEA5056E1","md5":"3D5BF92A3C2B7542B8371FE9C600DDE1"},"extraAttributes":{"countByCommentType":{"CATALYTIC ACTIVITY":1},"countByFeatureType":{"Binding site":6},"uniParcId":"UPI0000E5B247"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0A012","uniProtkbId":"A0A012_STRVD","entryAudit":{"firstPublicDate":"2006-11-14","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2006-11-14","entryVersion":26,"sequenceVersion":1},"annotationScore":1.0,"organism":{"scientificName":"Streptomyces viridosporus","taxonId":67581,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ABJ90165.1"}],"lineage":["Bacteria","Bacillati","Actinomycetota","Actinomycetes","Kitasatosporales","Streptomycetaceae","Streptomyces"]},"proteinExistence":"4: Predicted","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ABJ90165.1"}],"value":"MoeX5"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ABJ90165.1"}],"value":"moeX5"}}],"features":[{"type":"Transmembrane","location":{"start":{"value":20,"modifier":"EXACT"},"end":{"value":37,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":43,"modifier":"EXACT"},"end":{"value":64,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":84,"modifier":"EXACT"},"end":{"value":105,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":117,"modifier":"EXACT"},"end":{"value":140,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":147,"modifier":"EXACT"},"end":{"value":163,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":195,"modifier":"EXACT"},"end":{"value":215,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-1133","category":"Domain","name":"Transmembrane helix"}],"references":[{"referenceNumber":1,"citation":{"id":"CI-9LAJ522RF4IIS","citationType":"submission","authors":["Ostash B.O.","Walker S."],"publicationDate":"SEP-2006","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ABJ90165.1"}],"value":"ATCC14672","type":"STRAIN"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ABJ90165.1"}]},{"referenceNumber":2,"citation":{"id":"17379141","citationType":"journal article","authors":["Ostash B.","Saghatelian A.","Walker S."],"citationCrossReferences":[{"database":"PubMed","id":"17379141"},{"database":"DOI","id":"10.1016/j.chembiol.2007.01.008"}],"title":"A streamlined metabolic pathway for the biosynthesis of moenomycin A.","publicationDate":"2007","journal":"Chem. Biol.","firstPage":"257","lastPage":"267","volume":"14"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ABJ90165.1"}],"value":"ATCC14672","type":"STRAIN"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ABJ90165.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"DQ988994","properties":[{"key":"ProteinId","value":"ABJ90165.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"RefSeq","id":"WP_016823899.1","properties":[{"key":"NucleotideSequenceId","value":"NZ_JBEOYY010000017.1"}]},{"database":"AlphaFoldDB","id":"A0A012","properties":[{"key":"Description","value":"-"}]},{"database":"GeneID","id":"307735488","properties":[{"key":"Description","value":"-"}]}],"sequence":{"value":"MTATLRMAEMTFRELLRRRGVLGLLLLVPLVFYLGRYDQTGQAVRFASLGVGFAVSAAALFSAVGGREIEPLLALSGFRPLQLFLGRLLALLTAGMGVSALYAVIILVGQDVAHPRAVAVELALTTLVAVPLGLLLGAAVPRDMEGALLLISVIGAQMVMDPAKDSAKVLPFWSTREIITYAVDGADSGSFDSGVAHAVGVTLLLVAVSGCVTAGRLRRRRHLQFA","length":226,"molWeight":23839,"crc64":"D3B622FCFBF92F74","md5":"77CE56DF7B82751280247C3B99B7957E"},"extraAttributes":{"countByFeatureType":{"Transmembrane":6},"uniParcId":"UPI0000E5B248"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0A013","uniProtkbId":"A0A013_STRVD","entryAudit":{"firstPublicDate":"2006-11-14","lastAnnotationUpdateDate":"2026-11-04","lastSequenceUpdateDate":"2006-11-14","entryVersion":57,"sequenceVersion":1},"annotationScore":1.0,"organism":{"scientificName":"Streptomyces viridosporus","taxonId":67581,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ABJ90166.1"}],"lineage":["Bacteria","Bacillati","Actinomycetota","Actinomycetes","Kitasatosporales","Streptomycetaceae","Streptomyces"]},"proteinExistence":"4: Predicted","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ABJ90166.1"}],"value":"MoeP5"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ABJ90166.1"}],"value":"moeP5"}}],"features":[{"type":"Domain","location":{"start":{"value":24,"modifier":"EXACT"},"end":{"value":223,"modifier":"EXACT"}},"description":"ABC transporter","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50893"}]},{"type":"Binding site","location":{"start":{"value":56,"modifier":"EXACT"},"end":{"value":63,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:30616"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00434"}],"ligand":{"name":"ATP","id":"ChEBI:CHEBI:30616"}}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022840"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00434"}],"id":"KW-0067","category":"Ligand","name":"ATP-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022741"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00434"}],"id":"KW-0547","category":"Ligand","name":"Nucleotide-binding"}],"references":[{"referenceNumber":1,"citation":{"id":"CI-9LAJ522RF4IIS","citationType":"submission","authors":["Ostash B.O.","Walker S."],"publicationDate":"SEP-2006","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ABJ90166.1"}],"value":"ATCC14672","type":"STRAIN"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ABJ90166.1"}]},{"referenceNumber":2,"citation":{"id":"17379141","citationType":"journal article","authors":["Ostash B.","Saghatelian A.","Walker S."],"citationCrossReferences":[{"database":"PubMed","id":"17379141"},{"database":"DOI","id":"10.1016/j.chembiol.2007.01.008"}],"title":"A streamlined metabolic pathway for the biosynthesis of moenomycin A.","publicationDate":"2007","journal":"Chem. Biol.","firstPage":"257","lastPage":"267","volume":"14"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ABJ90166.1"}],"value":"ATCC14672","type":"STRAIN"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ABJ90166.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"DQ988994","properties":[{"key":"ProteinId","value":"ABJ90166.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"RefSeq","id":"WP_016823900.1","properties":[{"key":"NucleotideSequenceId","value":"NZ_JBPUKI010000009.1"}]},{"database":"AlphaFoldDB","id":"A0A013","properties":[{"key":"Description","value":"-"}]},{"database":"GeneID","id":"307735487","properties":[{"key":"Description","value":"-"}]},{"database":"GO","id":"GO:0005524","properties":[{"key":"GoTerm","value":"F:ATP binding"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniRule"}]},{"database":"GO","id":"GO:0016887","properties":[{"key":"GoTerm","value":"F:ATP hydrolysis activity"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"Gene3D","id":"3.40.50.300","properties":[{"key":"EntryName","value":"P-loop containing nucleotide triphosphate hydrolases"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR003593","properties":[{"key":"EntryName","value":"AAA+_ATPase"}]},{"database":"InterPro","id":"IPR003439","properties":[{"key":"EntryName","value":"ABC_transporter-like_ATP-bd"}]},{"database":"InterPro","id":"IPR027417","properties":[{"key":"EntryName","value":"P-loop_NTPase"}]},{"database":"PANTHER","id":"PTHR43038:SF7","properties":[{"key":"EntryName","value":"ABC TRANSPORT SYSTEM ATP-BINDING PROTEIN"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR43038","properties":[{"key":"EntryName","value":"ATP-BINDING CASSETTE, SUB-FAMILY H, MEMBER 1"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00005","properties":[{"key":"EntryName","value":"ABC_tran"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00382","properties":[{"key":"EntryName","value":"AAA"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF52540","properties":[{"key":"EntryName","value":"P-loop containing nucleoside triphosphate hydrolases"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50893","properties":[{"key":"EntryName","value":"ABC_TRANSPORTER_2"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MGHSVGAREGYHGMSEPADRKILLQARGVVKRYKRRRVLTGVDLVVHAGEVAAIVGSNGTGKSTLLKICAGLLSPDKGRVTVSGHLGYCPQNAGVMGFLTPREHFTLFGTGRGLSRRESDRRGRRLAGELDWAPAEGVLAKDLSGGTRQKLNVVLSALGDPDLLLLDEPYQGFDHGSYVDFWQSVWEWREAGKAVVVVTHMLNQLDRVDQVLDLTPGKGRGNR","length":223,"molWeight":24280,"crc64":"747952641879EA66","md5":"DBFB47A92163D3DD6897D3AF4644B7AF"},"extraAttributes":{"countByFeatureType":{"Domain":1,"Binding site":1},"uniParcId":"UPI0000E5B249"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0A014","uniProtkbId":"A0A014_STRVD","entryAudit":{"firstPublicDate":"2006-11-14","lastAnnotationUpdateDate":"2025-02-05","lastSequenceUpdateDate":"2006-11-14","entryVersion":18,"sequenceVersion":1},"annotationScore":1.0,"organism":{"scientificName":"Streptomyces viridosporus","taxonId":67581,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ABJ90167.1"}],"lineage":["Bacteria","Bacillati","Actinomycetota","Actinomycetes","Kitasatosporales","Streptomycetaceae","Streptomyces"]},"proteinExistence":"4: Predicted","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ABJ90167.1"}],"value":"MoeGT5"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ABJ90167.1"}],"value":"moeGT5"}}],"references":[{"referenceNumber":1,"citation":{"id":"CI-9LAJ522RF4IIS","citationType":"submission","authors":["Ostash B.O.","Walker S."],"publicationDate":"SEP-2006","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ABJ90167.1"}],"value":"ATCC14672","type":"STRAIN"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ABJ90167.1"}]},{"referenceNumber":2,"citation":{"id":"17379141","citationType":"journal article","authors":["Ostash B.","Saghatelian A.","Walker S."],"citationCrossReferences":[{"database":"PubMed","id":"17379141"},{"database":"DOI","id":"10.1016/j.chembiol.2007.01.008"}],"title":"A streamlined metabolic pathway for the biosynthesis of moenomycin A.","publicationDate":"2007","journal":"Chem. Biol.","firstPage":"257","lastPage":"267","volume":"14"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ABJ90167.1"}],"value":"ATCC14672","type":"STRAIN"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ABJ90167.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"DQ988994","properties":[{"key":"ProteinId","value":"ABJ90167.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"AlphaFoldDB","id":"A0A014","properties":[{"key":"Description","value":"-"}]}],"sequence":{"value":"MLRRLAEVREAHPSLPLTVWVGMQYGPGEDEEALRRLRRLCAPVPGGPALTVVGLALPGPGKLRTVSTVLRLSEDLGYAGWLWTDDDIEIAPHCLALLVSRFRERGERGAVGAHSVALARETVTSQAMDRVSGVTAPPKACPAAACLVVATDVLGTGIPVRRLTDDGYVVFELLDAGAPDPLHDLEVLPEARISFYRVSRTHDTFQRLRRSLYSHVTCVADYPWPTARVYLTRVLFHGLWPLAAWDGSRGPVHGLQRWLVKGLHFTWFCGVAGSLAVRGAVGRPLRRVAWGDEGDFRSPTVEEPAAGAAAGR","length":312,"molWeight":33958,"crc64":"408FEFE411A1F3BD","md5":"D2CF0B3E80DC992914B4AB087DC18A34"},"extraAttributes":{"uniParcId":"UPI0000E5B24A"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0A015","uniProtkbId":"A0A015_STRVD","entryAudit":{"firstPublicDate":"2006-11-14","lastAnnotationUpdateDate":"2025-02-05","lastSequenceUpdateDate":"2006-11-14","entryVersion":36,"sequenceVersion":1},"annotationScore":1.0,"organism":{"scientificName":"Streptomyces viridosporus","taxonId":67581,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ABJ90168.1"}],"lineage":["Bacteria","Bacillati","Actinomycetota","Actinomycetes","Kitasatosporales","Streptomycetaceae","Streptomyces"]},"proteinExistence":"4: Predicted","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ABJ90168.1"}],"value":"MoeGT2"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ABJ90168.1"}],"value":"moeGT2"}}],"features":[{"type":"Domain","location":{"start":{"value":27,"modifier":"EXACT"},"end":{"value":187,"modifier":"EXACT"}},"description":"Glycosyltransferase 2-like","evidences":[{"evidenceCode":"ECO:0000259","source":"Pfam","id":"PF00535"}]}],"references":[{"referenceNumber":1,"citation":{"id":"CI-9LAJ522RF4IIS","citationType":"submission","authors":["Ostash B.O.","Walker S."],"publicationDate":"SEP-2006","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ABJ90168.1"}],"value":"ATCC14672","type":"STRAIN"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ABJ90168.1"}]},{"referenceNumber":2,"citation":{"id":"17379141","citationType":"journal article","authors":["Ostash B.","Saghatelian A.","Walker S."],"citationCrossReferences":[{"database":"PubMed","id":"17379141"},{"database":"DOI","id":"10.1016/j.chembiol.2007.01.008"}],"title":"A streamlined metabolic pathway for the biosynthesis of moenomycin A.","publicationDate":"2007","journal":"Chem. Biol.","firstPage":"257","lastPage":"267","volume":"14"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ABJ90168.1"}],"value":"ATCC14672","type":"STRAIN"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ABJ90168.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"DQ988994","properties":[{"key":"ProteinId","value":"ABJ90168.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"AlphaFoldDB","id":"A0A015","properties":[{"key":"Description","value":"-"}]},{"database":"CDD","id":"cd00761","properties":[{"key":"EntryName","value":"Glyco_tranf_GTA_type"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.90.550.10","properties":[{"key":"EntryName","value":"Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR001173","properties":[{"key":"EntryName","value":"Glyco_trans_2-like"}]},{"database":"InterPro","id":"IPR050834","properties":[{"key":"EntryName","value":"Glycosyltransf_2"}]},{"database":"InterPro","id":"IPR029044","properties":[{"key":"EntryName","value":"Nucleotide-diphossugar_trans"}]},{"database":"PANTHER","id":"PTHR43685","properties":[{"key":"EntryName","value":"GLYCOSYLTRANSFERASE"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR43685:SF2","properties":[{"key":"EntryName","value":"GLYCOSYLTRANSFERASE 2-LIKE DOMAIN-CONTAINING PROTEIN"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00535","properties":[{"key":"EntryName","value":"Glycos_transf_2"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF53448","properties":[{"key":"EntryName","value":"Nucleotide-diphospho-sugar transferases"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MTHEVTPRGGPEGDAMVTAGPAGAAVTVVLPHYDCAAYLGAAVGSVLSQDRPDLRLTVVDECSPEEKWARALHPYAGDPRLTVVRTSRNVGHLRIKNKVLESVDTPYVAFQDADDISLPGRLRHQLALLESGGADLVGCAYSYIDEAGRTTGHRRMPRNGNLWMRLGRTTVLLHPSSVVRRSVLERLGGFDGTARLGADTDFHLRAARLYRLRSVRKVLYRYRIWPKSLTQAPDTGFGSAERRAYTEAMTAQEERRRRARTREELLPLLVAPPNDVDFTLTRVDLD","length":286,"molWeight":31752,"crc64":"0EF8A23EFB9F503A","md5":"119D5B0C221A573FF171E1B377139166"},"extraAttributes":{"countByFeatureType":{"Domain":1},"uniParcId":"UPI0000E5B24B"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0A016","uniProtkbId":"A0A016_STRVD","entryAudit":{"firstPublicDate":"2006-11-14","lastAnnotationUpdateDate":"2026-01-28","lastSequenceUpdateDate":"2006-11-14","entryVersion":41,"sequenceVersion":1},"annotationScore":1.0,"organism":{"scientificName":"Streptomyces viridosporus","taxonId":67581,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ABJ90169.1"}],"lineage":["Bacteria","Bacillati","Actinomycetota","Actinomycetes","Kitasatosporales","Streptomycetaceae","Streptomyces"]},"proteinExistence":"4: Predicted","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ABJ90169.1"}],"value":"MoeGT3"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ABJ90169.1"}],"value":"moeGT3"}}],"features":[{"type":"Domain","location":{"start":{"value":145,"modifier":"EXACT"},"end":{"value":257,"modifier":"EXACT"}},"description":"Glycosyltransferase 2-like","evidences":[{"evidenceCode":"ECO:0000259","source":"Pfam","id":"PF00535"}]},{"type":"Domain","location":{"start":{"value":280,"modifier":"EXACT"},"end":{"value":388,"modifier":"EXACT"}},"description":"Glycosyltransferase 2-like","evidences":[{"evidenceCode":"ECO:0000259","source":"Pfam","id":"PF13632"}]}],"references":[{"referenceNumber":1,"citation":{"id":"CI-9LAJ522RF4IIS","citationType":"submission","authors":["Ostash B.O.","Walker S."],"publicationDate":"SEP-2006","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ABJ90169.1"}],"value":"ATCC14672","type":"STRAIN"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ABJ90169.1"}]},{"referenceNumber":2,"citation":{"id":"17379141","citationType":"journal article","authors":["Ostash B.","Saghatelian A.","Walker S."],"citationCrossReferences":[{"database":"PubMed","id":"17379141"},{"database":"DOI","id":"10.1016/j.chembiol.2007.01.008"}],"title":"A streamlined metabolic pathway for the biosynthesis of moenomycin A.","publicationDate":"2007","journal":"Chem. Biol.","firstPage":"257","lastPage":"267","volume":"14"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ABJ90169.1"}],"value":"ATCC14672","type":"STRAIN"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ABJ90169.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"DQ988994","properties":[{"key":"ProteinId","value":"ABJ90169.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"AlphaFoldDB","id":"A0A016","properties":[{"key":"Description","value":"-"}]},{"database":"Gene3D","id":"3.90.550.10","properties":[{"key":"EntryName","value":"Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR001173","properties":[{"key":"EntryName","value":"Glyco_trans_2-like"}]},{"database":"InterPro","id":"IPR050834","properties":[{"key":"EntryName","value":"Glycosyltransf_2"}]},{"database":"InterPro","id":"IPR029044","properties":[{"key":"EntryName","value":"Nucleotide-diphossugar_trans"}]},{"database":"PANTHER","id":"PTHR43685","properties":[{"key":"EntryName","value":"GLYCOSYLTRANSFERASE"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR43685:SF2","properties":[{"key":"EntryName","value":"GLYCOSYLTRANSFERASE 2-LIKE DOMAIN-CONTAINING PROTEIN"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF13632","properties":[{"key":"EntryName","value":"Glyco_trans_2_3"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00535","properties":[{"key":"EntryName","value":"Glycos_transf_2"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF53448","properties":[{"key":"EntryName","value":"Nucleotide-diphospho-sugar transferases"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MAVLRGDDEALPHWLWHLARAVWYGGGDGTGPVGLVQCGALRLRDDGLVDGFALPPASPRTRPSPSDLLEGAYAVRRELLDADGGTAPWVALPMPLVRRRSGGAGDPAAVLAPGTRVARRTRLVRHGYRPPAARPRNGSTPRLVSVVVPVRNGARTLAAQLTALARQTGAVAYEVLVVDNGSTDTTREVAERARAELPDLRIVDASDRAGESCARNRGIAAARGDFVAFCDADDVADTGWLAAMAQAAKEADLVGGGLETSVLSPGRVDEQPLPMDAQTDFLPFARGANCGAWKDVLTALGGWDERYRGGGEDMDLSWRAQLCGYLVRYADDARMHYRLRDGLPALARQKWNYGRSGAQLYAAYRRAGFERRDGRVVVRNWCWLLLHVPNLVRSTGPCGHAESATRPAGRFPGL","length":414,"molWeight":44600,"crc64":"07C82361CC0EC528","md5":"133E1CDEE40379D13AA05E791E047D3D"},"extraAttributes":{"countByFeatureType":{"Domain":2},"uniParcId":"UPI0000E5B24C"}}]}