{"results":[{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"P14711","uniProtkbId":"HLYT_GRIHO","entryAudit":{"firstPublicDate":"1990-04-01","lastAnnotationUpdateDate":"2026-11-04","lastSequenceUpdateDate":"1990-04-01","entryVersion":68,"sequenceVersion":1},"annotationScore":3.0,"organism":{"scientificName":"Grimontia hollisae","commonName":"Vibrio hollisae","taxonId":673,"lineage":["Bacteria","Pseudomonadati","Pseudomonadota","Gammaproteobacteria","Vibrionales","Vibrionaceae","Grimontia"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"value":"Hemolysin, heat labile"}}},"comments":[{"texts":[{"value":"Bacterial hemolysins are exotoxins that attack blood cell membranes and cause cell rupture by mechanisms not clearly defined"}],"commentType":"FUNCTION"},{"texts":[{"value":"Homodimer"}],"commentType":"SUBUNIT"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Belongs to the TDH hemolysin family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":165,"modifier":"EXACT"}},"description":"Hemolysin, heat labile","featureId":"PRO_0000196247"},{"type":"Disulfide bond","location":{"start":{"value":151,"modifier":"EXACT"},"end":{"value":161,"modifier":"EXACT"}},"description":""},{"type":"Beta strand","location":{"start":{"value":15,"modifier":"EXACT"},"end":{"value":22,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"9L8E"}]},{"type":"Turn","location":{"start":{"value":23,"modifier":"EXACT"},"end":{"value":26,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4WX5"}]},{"type":"Beta strand","location":{"start":{"value":27,"modifier":"EXACT"},"end":{"value":29,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"9L8E"}]},{"type":"Beta strand","location":{"start":{"value":33,"modifier":"EXACT"},"end":{"value":46,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"9L8E"}]},{"type":"Beta strand","location":{"start":{"value":53,"modifier":"EXACT"},"end":{"value":61,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"9L8E"}]},{"type":"Beta strand","location":{"start":{"value":63,"modifier":"EXACT"},"end":{"value":74,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"9L8E"}]},{"type":"Beta strand","location":{"start":{"value":77,"modifier":"EXACT"},"end":{"value":88,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"9L8E"}]},{"type":"Beta strand","location":{"start":{"value":91,"modifier":"EXACT"},"end":{"value":100,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"9L8E"}]},{"type":"Helix","location":{"start":{"value":107,"modifier":"EXACT"},"end":{"value":114,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"9L8E"}]},{"type":"Helix","location":{"start":{"value":118,"modifier":"EXACT"},"end":{"value":120,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"9L8E"}]},{"type":"Beta strand","location":{"start":{"value":121,"modifier":"EXACT"},"end":{"value":129,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"9L8E"}]},{"type":"Beta strand","location":{"start":{"value":134,"modifier":"EXACT"},"end":{"value":142,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"9L8E"}]},{"type":"Beta strand","location":{"start":{"value":145,"modifier":"EXACT"},"end":{"value":153,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"9L8E"}]},{"type":"Turn","location":{"start":{"value":155,"modifier":"EXACT"},"end":{"value":157,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"9L8E"}]},{"type":"Helix","location":{"start":{"value":158,"modifier":"EXACT"},"end":{"value":161,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"9L8E"}]}],"keywords":[{"id":"KW-0002","category":"Technical term","name":"3D-structure"},{"id":"KW-0204","category":"Biological process","name":"Cytolysis"},{"id":"KW-0903","category":"Technical term","name":"Direct protein sequencing"},{"id":"KW-1015","category":"PTM","name":"Disulfide bond"},{"id":"KW-0354","category":"Biological process","name":"Hemolysis"},{"id":"KW-0800","category":"Molecular function","name":"Toxin"},{"id":"KW-0843","category":"Biological process","name":"Virulence"}],"references":[{"referenceNumber":1,"citation":{"id":"2592352","citationType":"journal article","authors":["Yoh M.","Honda T.","Miwatani T.","Tsunasawa S.","Sakiyama F."],"citationCrossReferences":[{"database":"PubMed","id":"2592352"},{"database":"DOI","id":"10.1128/jb.171.12.6859-6861.1989"}],"title":"Comparative amino acid sequence analysis of hemolysins produced by Vibrio hollisae and Vibrio parahaemolyticus.","publicationDate":"1989","journal":"J. Bacteriol.","firstPage":"6859","lastPage":"6861","volume":"171"},"referencePositions":["PROTEIN SEQUENCE"],"referenceComments":[{"value":"RIMD 2221001","type":"STRAIN"}]}],"uniProtKBCrossReferences":[{"database":"PIR","id":"A43728","properties":[{"key":"EntryName","value":"A43728"}]},{"database":"PDB","id":"4WX3","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.70 A"},{"key":"Chains","value":"A/B/C/D=1-165"}]},{"database":"PDB","id":"4WX5","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.30 A"},{"key":"Chains","value":"A/B/C/D=1-165"}]},{"database":"PDB","id":"9L8E","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.37 A"},{"key":"Chains","value":"A=1-165"}]},{"database":"AlphaFoldDB","id":"P14711","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"P14711","properties":[{"key":"Description","value":"-"}]},{"database":"GO","id":"GO:0005576","properties":[{"key":"GoTerm","value":"C:extracellular region"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0019836","properties":[{"key":"GoTerm","value":"P:symbiont-mediated hemolysis of host erythrocyte"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"Gene3D","id":"2.60.270.30","properties":[{"key":"EntryName","value":"Vibrio parahaemolyticus thermostable direct hemolysin"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR038689","properties":[{"key":"EntryName","value":"TDH_sf"}]},{"database":"InterPro","id":"IPR005015","properties":[{"key":"EntryName","value":"Thermostable_hemolysn_vibrio"}]},{"database":"Pfam","id":"PF03347","properties":[{"key":"EntryName","value":"TDH"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"FELPSIPFPSPGSDEILFVVRDTTFNTKEPVNVKVSDFWTNRNVKRKPYEDVYGQSVFTTSGSKWLTSYMTVSINNKDYTMAAVSGYKDGFSSVFVKSGQIQLQHYYNSVADFVGGDENSIPSKTYLDETPSYFVNVEAYESGSGNILVMCISNKESYFECEEQQ","length":165,"molWeight":18630,"crc64":"4A50A4A45C3808B6","md5":"9C5789EA5B23A33A16AE1DCABBCC2847"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"SUBUNIT":1,"SIMILARITY":1},"countByFeatureType":{"Chain":1,"Disulfide bond":1,"Beta strand":10,"Turn":2,"Helix":3},"uniParcId":"UPI000012C965"}},{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"P28031","uniProtkbId":"HLY1_GRIHO","entryAudit":{"firstPublicDate":"1992-08-01","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"1995-11-01","entryVersion":66,"sequenceVersion":2},"annotationScore":2.0,"organism":{"scientificName":"Grimontia hollisae","commonName":"Vibrio hollisae","taxonId":673,"lineage":["Bacteria","Pseudomonadati","Pseudomonadota","Gammaproteobacteria","Vibrionales","Vibrionaceae","Grimontia"]},"proteinExistence":"3: Inferred from homology","proteinDescription":{"recommendedName":{"fullName":{"value":"Thermostable direct hemolysin"}},"flag":"Precursor"},"genes":[{"geneName":{"value":"tdh"}}],"comments":[{"texts":[{"value":"Bacterial hemolysins are exotoxins that attack blood cell membranes and cause cell rupture by mechanisms not clearly defined"}],"commentType":"FUNCTION"},{"texts":[{"value":"Homodimer"}],"commentType":"SUBUNIT"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Belongs to the TDH hemolysin family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Signal","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":24,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000250"}]},{"type":"Chain","location":{"start":{"value":25,"modifier":"EXACT"},"end":{"value":189,"modifier":"EXACT"}},"description":"Thermostable direct hemolysin","featureId":"PRO_0000013360"},{"type":"Disulfide bond","location":{"start":{"value":175,"modifier":"EXACT"},"end":{"value":185,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000250"}]}],"keywords":[{"id":"KW-0204","category":"Biological process","name":"Cytolysis"},{"id":"KW-1015","category":"PTM","name":"Disulfide bond"},{"id":"KW-0354","category":"Biological process","name":"Hemolysis"},{"id":"KW-0732","category":"Domain","name":"Signal"},{"id":"KW-0800","category":"Molecular function","name":"Toxin"},{"id":"KW-0843","category":"Biological process","name":"Virulence"}],"references":[{"referenceNumber":1,"citation":{"id":"1884983","citationType":"journal article","authors":["Yamasaki S.","Shirai H.","Takeda Y.","Nishibuchi M."],"citationCrossReferences":[{"database":"PubMed","id":"1884983"},{"database":"DOI","id":"10.1016/0378-1097(91)90606-b"}],"title":"Analysis of the gene of Vibrio hollisae encoding the hemolysin similar to the thermostable direct hemolysin of Vibrio parahaemolyticus.","publicationDate":"1991","journal":"FEMS Microbiol. Lett.","firstPage":"259","lastPage":"263","volume":"64"},"referencePositions":["NUCLEOTIDE SEQUENCE [GENOMIC DNA]"],"referenceComments":[{"value":"9041","type":"STRAIN"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"M57900","properties":[{"key":"ProteinId","value":"AAA27570.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"PIR","id":"A54544","properties":[{"key":"EntryName","value":"A54544"}]},{"database":"AlphaFoldDB","id":"P28031","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"P28031","properties":[{"key":"Description","value":"-"}]},{"database":"STRING","id":"673.AL542_11315","properties":[{"key":"Description","value":"-"}]},{"database":"GO","id":"GO:0005576","properties":[{"key":"GoTerm","value":"C:extracellular region"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0019836","properties":[{"key":"GoTerm","value":"P:symbiont-mediated hemolysis of host erythrocyte"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"Gene3D","id":"2.60.270.30","properties":[{"key":"EntryName","value":"Vibrio parahaemolyticus thermostable direct hemolysin"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR038689","properties":[{"key":"EntryName","value":"TDH_sf"}]},{"database":"InterPro","id":"IPR005015","properties":[{"key":"EntryName","value":"Thermostable_hemolysn_vibrio"}]},{"database":"Pfam","id":"PF03347","properties":[{"key":"EntryName","value":"TDH"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MKYRHLAKKSFLFIFMLAAFKTFAFELPSIPFPSPGSDEILFVVRDTTFNTKEPVNVKVSDFWTNRNVKRKPYKDVHGQSVFITSGTKWLTSYMTVSINNKDYTMAAVSGYKDGFSSVFVKSGQIQLQHYYNSVADFVGGDENSIPSKTYLDETPEYFVNVEAYESGSGNILVMCISNKESYFECESQQ","length":189,"molWeight":21521,"crc64":"CB486133F308D0BF","md5":"F589472ADE5FFDCB9552C369C2B634AF"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"SUBUNIT":1,"SIMILARITY":1},"countByFeatureType":{"Signal":1,"Chain":1,"Disulfide bond":1},"uniParcId":"UPI000012C947"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0A0C5G3L9","uniProtkbId":"A0A0C5G3L9_GRIHO","entryAudit":{"firstPublicDate":"2015-04-29","lastAnnotationUpdateDate":"2026-11-04","lastSequenceUpdateDate":"2015-04-29","entryVersion":49,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Grimontia hollisae","commonName":"Vibrio hollisae","taxonId":673,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AJP07046.1"}],"lineage":["Bacteria","Pseudomonadati","Pseudomonadota","Gammaproteobacteria","Vibrionales","Vibrionaceae","Grimontia"]},"proteinExistence":"3: Inferred from homology","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00020910"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU364037"}],"value":"Ferric uptake regulation protein"}}},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU364037"},{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AJP07046.1"}],"value":"fur"},"orfNames":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"STO56970.1"}],"value":"NCTC11645_01346"}]}],"comments":[{"commentType":"COFACTOR","cofactors":[{"name":"Mn(2+)","evidences":[{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR602481-2"}],"cofactorCrossReference":{"database":"ChEBI","id":"CHEBI:29035"}},{"name":"Fe(2+)","evidences":[{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR602481-2"}],"cofactorCrossReference":{"database":"ChEBI","id":"CHEBI:29033"}}],"note":{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR602481-2"}],"value":"Binds 1 Mn(2+) or Fe(2+) ion per subunit."}]}},{"commentType":"COFACTOR","cofactors":[{"name":"Zn(2+)","evidences":[{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR602481-1"}],"cofactorCrossReference":{"database":"ChEBI","id":"CHEBI:29105"}}],"note":{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR602481-1"}],"value":"Binds 1 zinc ion per subunit."}]}},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00011738"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU364037"}],"value":"Homodimer"}],"commentType":"SUBUNIT"},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004496"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU364037"}],"value":"Cytoplasm","id":"SL-0086"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00007957"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU364037"}],"value":"Belongs to the Fur family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Binding site","location":{"start":{"value":87,"modifier":"EXACT"},"end":{"value":87,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:24875"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR602481-2"}],"ligand":{"name":"Fe cation","id":"ChEBI:CHEBI:24875"}},{"type":"Binding site","location":{"start":{"value":89,"modifier":"EXACT"},"end":{"value":89,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:24875"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR602481-2"}],"ligand":{"name":"Fe cation","id":"ChEBI:CHEBI:24875"}},{"type":"Binding site","location":{"start":{"value":93,"modifier":"EXACT"},"end":{"value":93,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29105"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR602481-1"}],"ligand":{"name":"Zn(2+)","id":"ChEBI:CHEBI:29105"}},{"type":"Binding site","location":{"start":{"value":96,"modifier":"EXACT"},"end":{"value":96,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29105"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR602481-1"}],"ligand":{"name":"Zn(2+)","id":"ChEBI:CHEBI:29105"}},{"type":"Binding site","location":{"start":{"value":108,"modifier":"EXACT"},"end":{"value":108,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:24875"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR602481-2"}],"ligand":{"name":"Fe cation","id":"ChEBI:CHEBI:24875"}},{"type":"Binding site","location":{"start":{"value":125,"modifier":"EXACT"},"end":{"value":125,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:24875"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR602481-2"}],"ligand":{"name":"Fe cation","id":"ChEBI:CHEBI:24875"}},{"type":"Binding site","location":{"start":{"value":133,"modifier":"EXACT"},"end":{"value":133,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29105"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR602481-1"}],"ligand":{"name":"Zn(2+)","id":"ChEBI:CHEBI:29105"}},{"type":"Binding site","location":{"start":{"value":138,"modifier":"EXACT"},"end":{"value":138,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29105"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR602481-1"}],"ligand":{"name":"Zn(2+)","id":"ChEBI:CHEBI:29105"}}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022490"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU364037"}],"id":"KW-0963","category":"Cellular component","name":"Cytoplasm"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023125"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU364037"}],"id":"KW-0238","category":"Molecular function","name":"DNA-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023004"},{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR602481-2"}],"id":"KW-0408","category":"Ligand","name":"Iron"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022723"},{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR602481-1"}],"id":"KW-0479","category":"Ligand","name":"Metal-binding"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AJP07046.1"}],"id":"KW-0560","category":"Molecular function","name":"Oxidoreductase"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AJP07046.1"}],"id":"KW-0575","category":"Molecular function","name":"Peroxidase"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022491"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU364037"}],"id":"KW-0678","category":"Molecular function","name":"Repressor"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023163"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU364037"}],"id":"KW-0804","category":"Biological process","name":"Transcription"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023015"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU364037"}],"id":"KW-0805","category":"Biological process","name":"Transcription regulation"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022833"},{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR602481-1"}],"id":"KW-0862","category":"Ligand","name":"Zinc"}],"references":[{"referenceNumber":1,"citation":{"id":"25662978","citationType":"journal article","authors":["Machado H.","Gram L."],"citationCrossReferences":[{"database":"PubMed","id":"25662978"}],"title":"The fur gene as a new phylogenetic marker for vibrionaceae species identification.","publicationDate":"2015","journal":"Appl. Environ. Microbiol.","firstPage":"2745","lastPage":"2752","volume":"81"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AJP07046.1"}],"value":"DSM 15132","type":"STRAIN"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AJP07046.1"}]},{"referenceNumber":2,"citation":{"id":"CI-AB4PR2KKK46L9","citationType":"submission","authoringGroup":["Pathogen Informatics"],"authors":["Doyle S."],"publicationDate":"JUN-2018","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"STO56970.1"}],"value":"NCTC11645","type":"STRAIN"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"STO56970.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"KP721382","properties":[{"key":"ProteinId","value":"AJP07046.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"UGHD01000002","properties":[{"key":"ProteinId","value":"STO56970.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"RefSeq","id":"WP_005506345.1","properties":[{"key":"NucleotideSequenceId","value":"NZ_CABMOB010000001.1"}]},{"database":"AlphaFoldDB","id":"A0A0C5G3L9","properties":[{"key":"Description","value":"-"}]},{"database":"STRING","id":"673.AL542_04525","properties":[{"key":"Description","value":"-"}]},{"database":"GeneID","id":"58895160","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"gho:AL542_04525","properties":[{"key":"Description","value":"-"}]},{"database":"GO","id":"GO:0005829","properties":[{"key":"GoTerm","value":"C:cytosol"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:0003700","properties":[{"key":"GoTerm","value":"F:DNA-binding transcription factor activity"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniRule"}]},{"database":"GO","id":"GO:0000976","properties":[{"key":"GoTerm","value":"F:transcription cis-regulatory region binding"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:0008270","properties":[{"key":"GoTerm","value":"F:zinc ion binding"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:0045892","properties":[{"key":"GoTerm","value":"P:negative regulation of DNA-templated transcription"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:1900705","properties":[{"key":"GoTerm","value":"P:negative regulation of siderophore biosynthetic process"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"CDD","id":"cd07153","properties":[{"key":"EntryName","value":"Fur_like"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.10.10.10:FF:000007","properties":[{"key":"EntryName","value":"Ferric uptake regulation protein"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.30.1490.190:FF:000001","properties":[{"key":"EntryName","value":"Ferric uptake regulation protein"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.30.1490.190","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.10.10.10","properties":[{"key":"EntryName","value":"Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR002481","properties":[{"key":"EntryName","value":"FUR"}]},{"database":"InterPro","id":"IPR043135","properties":[{"key":"EntryName","value":"Fur_C"}]},{"database":"InterPro","id":"IPR036388","properties":[{"key":"EntryName","value":"WH-like_DNA-bd_sf"}]},{"database":"InterPro","id":"IPR036390","properties":[{"key":"EntryName","value":"WH_DNA-bd_sf"}]},{"database":"NCBIfam","id":"NF006999","properties":[{"key":"EntryName","value":"fur"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR33202:SF2","properties":[{"key":"EntryName","value":"FERRIC UPTAKE REGULATION PROTEIN"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR33202","properties":[{"key":"EntryName","value":"ZINC UPTAKE REGULATION PROTEIN"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF01475","properties":[{"key":"EntryName","value":"FUR"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF46785","properties":[{"key":"EntryName","value":"Winged helix' DNA-binding domain"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MSDNNKALKDAGLKVTLPRLKILEVLQEPDCQHISAEDLYKKLIDIGEEIGLATVYRVLNQFDDAGIVTRHHFEGGKSVFELATQHHHDHLVCLDCGRVIEFTDEVIEQRQRDIANQYNIRLTNHSLYLYGHCTKSGCKDDPSLHDA","length":147,"molWeight":16723,"crc64":"41380E9EEDEB3C0A","md5":"F519F66D44E9F9E935FB0DBE4D5E5727"},"extraAttributes":{"countByCommentType":{"COFACTOR":2,"SUBUNIT":1,"SUBCELLULAR LOCATION":1,"SIMILARITY":1},"countByFeatureType":{"Binding site":8},"uniParcId":"UPI0001BB229A"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0A377HK12","uniProtkbId":"A0A377HK12_GRIHO","entryAudit":{"firstPublicDate":"2018-11-07","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2018-11-07","entryVersion":27,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Grimontia hollisae","commonName":"Vibrio hollisae","taxonId":673,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"STO56062.1"}],"lineage":["Bacteria","Pseudomonadati","Pseudomonadota","Gammaproteobacteria","Vibrionales","Vibrionaceae","Grimontia"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"STO56062.1"}],"value":"Thermostable direct hemolysin-related"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"STO56062.1"}],"value":"tdh3"},"orfNames":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"STO56062.1"}],"value":"NCTC11645_00376"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00002376"}],"value":"Bacterial hemolysins are exotoxins that attack blood cell membranes and cause cell rupture by mechanisms not clearly defined"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00011738"}],"value":"Homodimer"}],"commentType":"SUBUNIT"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00010911"}],"value":"Belongs to the TDH hemolysin family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Signal","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":24,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}]},{"type":"Chain","location":{"start":{"value":25,"modifier":"EXACT"},"end":{"value":189,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"featureId":"PRO_5016623235"},{"type":"Disulfide bond","location":{"start":{"value":175,"modifier":"EXACT"},"end":{"value":185,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"9L9M"},{"evidenceCode":"ECO:0007829","source":"PDB","id":"9LCM"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"9L9M"},{"evidenceCode":"ECO:0007829","source":"PDB","id":"9LCM"}],"id":"KW-0002","category":"Technical term","name":"3D-structure"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022852"}],"id":"KW-0204","category":"Biological process","name":"Cytolysis"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023157"}],"id":"KW-1015","category":"PTM","name":"Disulfide bond"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022735"}],"id":"KW-0354","category":"Biological process","name":"Hemolysis"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"id":"KW-0732","category":"Domain","name":"Signal"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022656"}],"id":"KW-0800","category":"Molecular function","name":"Toxin"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023026"}],"id":"KW-0843","category":"Biological process","name":"Virulence"}],"references":[{"referenceNumber":1,"citation":{"id":"CI-AB4PR2KKK46L9","citationType":"submission","authoringGroup":["Pathogen Informatics"],"authors":["Doyle S."],"publicationDate":"JUN-2018","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"STO56062.1"}],"value":"NCTC11645","type":"STRAIN"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"STO56062.1"}]},{"referenceNumber":2,"citation":{"id":"CI-7EHS165DCSBQ0","citationType":"submission","authors":["Hsiao P.Y.","Wu T.K.","Chang C.Y."],"title":"Structure of Gh-TDH in Complex with 10-nt match Double-Stranded DNA.","publicationDate":"DEC-2024","submissionDatabase":"PDB data bank"},"referencePositions":["X-RAY CRYSTALLOGRAPHY (1.42 ANGSTROMS) OF 25-189","DISULFIDE BONDS"],"evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"9L9M"}]},{"referenceNumber":3,"citation":{"id":"CI-61NR0NHJMOH1A","citationType":"submission","authors":["Hsiao P.Y.","Wu T.K.","Chang C.Y."],"title":"Grimontia hollisae thermostable direct hemolysin in complex with 1-nt long 3'-overhang dsDNA.","publicationDate":"JAN-2025","submissionDatabase":"PDB data bank"},"referencePositions":["X-RAY CRYSTALLOGRAPHY (2.32 ANGSTROMS) OF 25-189","DISULFIDE BONDS"],"evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"9LCU"}]},{"referenceNumber":4,"citation":{"id":"CI-C19UE0J2U337M","citationType":"submission","authors":["Hsiao P.Y.","Wu T.K.","Chang C.Y."],"title":"Grimontia hollisae thermostable direct hemolysin in complex with 2-nt long 5'-overhang dsDNA.","publicationDate":"JAN-2025","submissionDatabase":"PDB data bank"},"referencePositions":["X-RAY CRYSTALLOGRAPHY (1.58 ANGSTROMS) OF 25-189","DISULFIDE BONDS"],"evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"9LCS"}]},{"referenceNumber":5,"citation":{"id":"CI-7DLCUMJNSERUJ","citationType":"submission","authors":["Hsiao P.Y.","Wu T.K.","Chang C.Y."],"title":"Grimontia hollisae thermostable direct hemolysin in complex with 6-nt blunt-ended dsDNA.","publicationDate":"JAN-2025","submissionDatabase":"PDB data bank"},"referencePositions":["X-RAY CRYSTALLOGRAPHY (1.82 ANGSTROMS) OF 25-189","DISULFIDE BONDS"],"evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"9LCM"}]},{"referenceNumber":6,"citation":{"id":"CI-1P06ABROANVA9","citationType":"submission","authors":["Hsiao P.Y.","Wu T.K.","Chang C.Y."],"title":"Grimontia hollisae thermostable direct hemolysin K88A mutant in complex with 1-nt long 3'-overhang dsDNA.","publicationDate":"JAN-2025","submissionDatabase":"PDB data bank"},"referencePositions":["X-RAY CRYSTALLOGRAPHY (2.71 ANGSTROMS) OF 25-189","DISULFIDE BONDS"],"evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"9LCW"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"UGHD01000002","properties":[{"key":"ProteinId","value":"STO56062.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"RefSeq","id":"WP_040528653.1","properties":[{"key":"NucleotideSequenceId","value":"NZ_CP014056.2"}]},{"database":"PDB","id":"9L9M","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.42 A"},{"key":"Chains","value":"A=25-189"}]},{"database":"PDB","id":"9LCM","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.82 A"},{"key":"Chains","value":"A/B=25-189"}]},{"database":"PDB","id":"9LCS","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.58 A"},{"key":"Chains","value":"A=25-189"}]},{"database":"PDB","id":"9LCU","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.32 A"},{"key":"Chains","value":"A/B/C/D=25-189"}]},{"database":"PDB","id":"9LCW","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.71 A"},{"key":"Chains","value":"A/B/C/D=25-189"}]},{"database":"AlphaFoldDB","id":"A0A377HK12","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"A0A377HK12","properties":[{"key":"Description","value":"-"}]},{"database":"GeneID","id":"58896514","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"gho:AL542_11315","properties":[{"key":"Description","value":"-"}]},{"database":"GO","id":"GO:0005576","properties":[{"key":"GoTerm","value":"C:extracellular region"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0019836","properties":[{"key":"GoTerm","value":"P:symbiont-mediated hemolysis of host erythrocyte"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"Gene3D","id":"2.60.270.30","properties":[{"key":"EntryName","value":"Vibrio parahaemolyticus thermostable direct hemolysin"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR038689","properties":[{"key":"EntryName","value":"TDH_sf"}]},{"database":"InterPro","id":"IPR005015","properties":[{"key":"EntryName","value":"Thermostable_hemolysn_vibrio"}]},{"database":"Pfam","id":"PF03347","properties":[{"key":"EntryName","value":"TDH"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MKYRHLAKKSFLFIFMLAAFKTFAFELPSIPFPSPGSDEILFVVRDTTFNTKEPVNVKVSDFWTNRNVKRKPYKDVYGQSVFTTSGSKWLTSYMTVSINNKDYTMAAVSGYKDGFSSVFVKSGQIQLQHYYNSVADFVGGDENSIPSKTYLDETPEYFVNVEAYESGSGNILVMCISNKESYFECESQQ","length":189,"molWeight":21521,"crc64":"480157148C5F3A93","md5":"1FCE4956934189F4C6EBC99CCEAA57CD"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"SUBUNIT":1,"SIMILARITY":1},"countByFeatureType":{"Signal":1,"Chain":1,"Disulfide bond":1},"uniParcId":"UPI00059088A0"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A1DW16","uniProtkbId":"A1DW16_GRIHO","entryAudit":{"firstPublicDate":"2007-01-23","lastAnnotationUpdateDate":"2026-11-04","lastSequenceUpdateDate":"2007-01-23","entryVersion":63,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Grimontia hollisae","commonName":"Vibrio hollisae","taxonId":673,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ABL09922.1"}],"lineage":["Bacteria","Pseudomonadati","Pseudomonadota","Gammaproteobacteria","Vibrionales","Vibrionaceae","Grimontia"]},"proteinExistence":"3: Inferred from homology","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00012418"}],"value":"DNA-directed RNA polymerase"},"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00012418"}],"value":"2.7.7.6"}]},"flag":"Fragment"},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ABL09922.1"}],"value":"rpoB"}}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000434"}],"value":"Belongs to the RNA polymerase beta chain family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Domain","location":{"start":{"value":11,"modifier":"EXACT"},"end":{"value":72,"modifier":"EXACT"}},"description":"RNA polymerase Rpb2","evidences":[{"evidenceCode":"ECO:0000259","source":"Pfam","id":"PF04561"}]},{"type":"Domain","location":{"start":{"value":131,"modifier":"EXACT"},"end":{"value":198,"modifier":"EXACT"}},"description":"RNA polymerase Rpb2","evidences":[{"evidenceCode":"ECO:0000259","source":"Pfam","id":"PF04565"}]},{"type":"Domain","location":{"start":{"value":209,"modifier":"EXACT"},"end":{"value":274,"modifier":"EXACT"}},"description":"DNA-directed RNA polymerase beta subunit external 1","evidences":[{"evidenceCode":"ECO:0000259","source":"Pfam","id":"PF10385"}]},{"type":"Non-terminal residue","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":1,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ABL09922.1"}]},{"type":"Non-terminal residue","location":{"start":{"value":290,"modifier":"EXACT"},"end":{"value":290,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ABL09922.1"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022478"}],"id":"KW-0240","category":"Cellular component","name":"DNA-directed RNA polymerase"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022695"}],"id":"KW-0548","category":"Molecular function","name":"Nucleotidyltransferase"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023163"}],"id":"KW-0804","category":"Biological process","name":"Transcription"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022679"}],"id":"KW-0808","category":"Molecular function","name":"Transferase"}],"references":[{"referenceNumber":1,"citation":{"id":"17093013","citationType":"journal article","authors":["Tarr C.L.","Patel J.S.","Puhr N.D.","Sowers E.G.","Bopp C.A.","Strockbine N.A."],"citationCrossReferences":[{"database":"PubMed","id":"17093013"},{"database":"DOI","id":"10.1128/JCM.01544-06"}],"title":"Identification of Vibrio isolates by a multiplex PCR assay and rpoB sequence determination.","publicationDate":"2007","journal":"J. Clin. Microbiol.","firstPage":"134","lastPage":"140","volume":"45"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ABL09928.1"}],"value":"2429-03","type":"STRAIN"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ABL09924.1"}],"value":"2446-03","type":"STRAIN"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ABL09922.1"}],"value":"F8890","type":"STRAIN"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ABL09923.1"}],"value":"F9489","type":"STRAIN"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ABL09922.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"EF064431","properties":[{"key":"ProteinId","value":"ABL09922.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"EF064432","properties":[{"key":"ProteinId","value":"ABL09923.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"EF064433","properties":[{"key":"ProteinId","value":"ABL09924.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"EF064437","properties":[{"key":"ProteinId","value":"ABL09928.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"AlphaFoldDB","id":"A1DW16","properties":[{"key":"Description","value":"-"}]},{"database":"GO","id":"GO:0003677","properties":[{"key":"GoTerm","value":"F:DNA binding"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0003899","properties":[{"key":"GoTerm","value":"F:DNA-directed RNA polymerase activity"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-EC"}]},{"database":"GO","id":"GO:0032549","properties":[{"key":"GoTerm","value":"F:ribonucleoside binding"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0006351","properties":[{"key":"GoTerm","value":"P:DNA-templated transcription"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"FunFam","id":"2.30.150.10:FF:000001","properties":[{"key":"EntryName","value":"DNA-directed RNA polymerase subunit beta"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.90.1100.10","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.90.1110.10","properties":[{"key":"EntryName","value":"RNA polymerase Rpb2, domain 2"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR019462","properties":[{"key":"EntryName","value":"DNA-dir_RNA_pol_bsu_external_1"}]},{"database":"InterPro","id":"IPR015712","properties":[{"key":"EntryName","value":"DNA-dir_RNA_pol_su2"}]},{"database":"InterPro","id":"IPR007642","properties":[{"key":"EntryName","value":"RNA_pol_Rpb2_2"}]},{"database":"InterPro","id":"IPR037034","properties":[{"key":"EntryName","value":"RNA_pol_Rpb2_2_sf"}]},{"database":"InterPro","id":"IPR007645","properties":[{"key":"EntryName","value":"RNA_pol_Rpb2_3"}]},{"database":"PANTHER","id":"PTHR20856","properties":[{"key":"EntryName","value":"DNA-DIRECTED RNA POLYMERASE I SUBUNIT 2"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF04561","properties":[{"key":"EntryName","value":"RNA_pol_Rpb2_2"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF04565","properties":[{"key":"EntryName","value":"RNA_pol_Rpb2_3"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF10385","properties":[{"key":"EntryName","value":"RNA_pol_Rpb2_45"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF64484","properties":[{"key":"EntryName","value":"beta and beta-prime subunits of DNA dependent RNA-polymerase"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"QLFESLFFSEDRYDLSAVGRMKFNSSLGREEMTGSGVLSHDDIIEVMRKLIDIRNGIGEVDDIDHLGNRRIRSVGEMAENQFRVGLVRVERAVKERLSLGDLDNVMPQDLINAKPISAAVKEFFGSSQLSQFMDQNNPLSEVTHKRRISALGPGGLTRERAGFEVRDVHATHYGRLCPIETPEGPNIGLINSLSAFARTNPYGFLETPYRKVVDGKVTDEIDYLSAIEEGQFVIAQANAVLNEDGSFADELITARQKGESGLHPRDHVQYMDVATNQVVSVAASLIPFLE","length":290,"molWeight":32180,"crc64":"D6DA2D04C2A5C386","md5":"0469F206A400FCFCFD629B185CD4E97F"},"extraAttributes":{"countByCommentType":{"SIMILARITY":1},"countByFeatureType":{"Domain":3,"Non-terminal residue":2},"uniParcId":"UPI0000EA2B45"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A1DW19","uniProtkbId":"A1DW19_GRIHO","entryAudit":{"firstPublicDate":"2007-01-23","lastAnnotationUpdateDate":"2026-11-04","lastSequenceUpdateDate":"2007-01-23","entryVersion":63,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Grimontia hollisae","commonName":"Vibrio hollisae","taxonId":673,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ABL09925.1"}],"lineage":["Bacteria","Pseudomonadati","Pseudomonadota","Gammaproteobacteria","Vibrionales","Vibrionaceae","Grimontia"]},"proteinExistence":"3: Inferred from homology","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00012418"}],"value":"DNA-directed RNA polymerase"},"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00012418"}],"value":"2.7.7.6"}]},"flag":"Fragment"},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ABL09925.1"}],"value":"rpoB"}}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000434"}],"value":"Belongs to the RNA polymerase beta chain family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Domain","location":{"start":{"value":11,"modifier":"EXACT"},"end":{"value":72,"modifier":"EXACT"}},"description":"RNA polymerase Rpb2","evidences":[{"evidenceCode":"ECO:0000259","source":"Pfam","id":"PF04561"}]},{"type":"Domain","location":{"start":{"value":131,"modifier":"EXACT"},"end":{"value":198,"modifier":"EXACT"}},"description":"RNA polymerase Rpb2","evidences":[{"evidenceCode":"ECO:0000259","source":"Pfam","id":"PF04565"}]},{"type":"Domain","location":{"start":{"value":209,"modifier":"EXACT"},"end":{"value":274,"modifier":"EXACT"}},"description":"DNA-directed RNA polymerase beta subunit external 1","evidences":[{"evidenceCode":"ECO:0000259","source":"Pfam","id":"PF10385"}]},{"type":"Non-terminal residue","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":1,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ABL09925.1"}]},{"type":"Non-terminal residue","location":{"start":{"value":290,"modifier":"EXACT"},"end":{"value":290,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ABL09925.1"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022478"}],"id":"KW-0240","category":"Cellular component","name":"DNA-directed RNA polymerase"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022695"}],"id":"KW-0548","category":"Molecular function","name":"Nucleotidyltransferase"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023163"}],"id":"KW-0804","category":"Biological process","name":"Transcription"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022679"}],"id":"KW-0808","category":"Molecular function","name":"Transferase"}],"references":[{"referenceNumber":1,"citation":{"id":"17093013","citationType":"journal article","authors":["Tarr C.L.","Patel J.S.","Puhr N.D.","Sowers E.G.","Bopp C.A.","Strockbine N.A."],"citationCrossReferences":[{"database":"PubMed","id":"17093013"},{"database":"DOI","id":"10.1128/JCM.01544-06"}],"title":"Identification of Vibrio isolates by a multiplex PCR assay and rpoB sequence determination.","publicationDate":"2007","journal":"J. Clin. Microbiol.","firstPage":"134","lastPage":"140","volume":"45"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ABL09925.1"}],"value":"F9039","type":"STRAIN"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ABL09925.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"EF064434","properties":[{"key":"ProteinId","value":"ABL09925.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"AlphaFoldDB","id":"A1DW19","properties":[{"key":"Description","value":"-"}]},{"database":"GO","id":"GO:0003677","properties":[{"key":"GoTerm","value":"F:DNA binding"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0003899","properties":[{"key":"GoTerm","value":"F:DNA-directed RNA polymerase activity"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-EC"}]},{"database":"GO","id":"GO:0032549","properties":[{"key":"GoTerm","value":"F:ribonucleoside binding"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0006351","properties":[{"key":"GoTerm","value":"P:DNA-templated transcription"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"Gene3D","id":"3.90.1100.10","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.90.1110.10","properties":[{"key":"EntryName","value":"RNA polymerase Rpb2, domain 2"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR019462","properties":[{"key":"EntryName","value":"DNA-dir_RNA_pol_bsu_external_1"}]},{"database":"InterPro","id":"IPR015712","properties":[{"key":"EntryName","value":"DNA-dir_RNA_pol_su2"}]},{"database":"InterPro","id":"IPR007642","properties":[{"key":"EntryName","value":"RNA_pol_Rpb2_2"}]},{"database":"InterPro","id":"IPR037034","properties":[{"key":"EntryName","value":"RNA_pol_Rpb2_2_sf"}]},{"database":"InterPro","id":"IPR007645","properties":[{"key":"EntryName","value":"RNA_pol_Rpb2_3"}]},{"database":"PANTHER","id":"PTHR20856","properties":[{"key":"EntryName","value":"DNA-DIRECTED RNA POLYMERASE I SUBUNIT 2"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF04561","properties":[{"key":"EntryName","value":"RNA_pol_Rpb2_2"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF04565","properties":[{"key":"EntryName","value":"RNA_pol_Rpb2_3"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF10385","properties":[{"key":"EntryName","value":"RNA_pol_Rpb2_45"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF64484","properties":[{"key":"EntryName","value":"beta and beta-prime subunits of DNA dependent RNA-polymerase"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"QLFESLFFSEDRYDLSAVGRMKFNSSLGREEMTGSGVLSHDDIIEVMRKLIDIRNGIGEVDDIDHLGNRRIRSVGEMAENQFRVGLVRVERAVKERLSLGDLDNVMPQDLINAKPISAAVKEFFGSSQLSQFMDQNNPLSEVTHKRRISALGPGGLTRERAGFEVRDVHATHYGRLCPIETPEGPNIGLINSLSAFARTNPYGFLETPYRKVVDGKVTDEIDYLSAIEEGQFVIAQANAALNEDGSFADELITARQKGESGLHPRDHVQYMDVATNQVVSVAASLIPFLE","length":290,"molWeight":32152,"crc64":"D6DA343974679386","md5":"CE561622C8EFE2C6A841C8D48731651B"},"extraAttributes":{"countByCommentType":{"SIMILARITY":1},"countByFeatureType":{"Domain":3,"Non-terminal residue":2},"uniParcId":"UPI0000EA2337"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A8S701","uniProtkbId":"A8S701_GRIHO","entryAudit":{"firstPublicDate":"2008-01-15","lastAnnotationUpdateDate":"2026-11-04","lastSequenceUpdateDate":"2008-01-15","entryVersion":78,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Grimontia hollisae","commonName":"Vibrio hollisae","taxonId":673,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ABV31270.1"}],"lineage":["Bacteria","Pseudomonadati","Pseudomonadota","Gammaproteobacteria","Vibrionales","Vibrionaceae","Grimontia"]},"proteinExistence":"3: Inferred from homology","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ABV31270.1"}],"value":"ATPase"}}],"flag":"Fragment"},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ABV31270.1"}],"value":"atpA"}}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00003784"}],"value":"Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit"}],"commentType":"FUNCTION"},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"ATP + H2O + 4 H(+)(in) = ADP + phosphate + 5 H(+)(out)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:57720"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:30616"},{"database":"ChEBI","id":"CHEBI:43474"},{"database":"ChEBI","id":"CHEBI:456216"}],"ecNumber":"7.1.2.2","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU10106"}]}},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00026013"}],"value":"F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has four main subunits: a(1), b(1), b'(1) and c(9-12)"}],"commentType":"SUBUNIT"},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004370"}],"value":"Membrane","id":"SL-0162"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00024342"}],"value":"Belongs to the ATPase alpha/beta chains family. T3SS ATPase subfamily"}],"commentType":"SIMILARITY"}],"features":[{"type":"Domain","location":{"start":{"value":4,"modifier":"EXACT"},"end":{"value":56,"modifier":"EXACT"}},"description":"ATPase F1/V1/A1 complex alpha/beta subunit N-terminal","evidences":[{"evidenceCode":"ECO:0000259","source":"Pfam","id":"PF02874"}]},{"type":"Domain","location":{"start":{"value":113,"modifier":"EXACT"},"end":{"value":339,"modifier":"EXACT"}},"description":"ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding","evidences":[{"evidenceCode":"ECO:0000259","source":"Pfam","id":"PF00006"}]},{"type":"Domain","location":{"start":{"value":346,"modifier":"EXACT"},"end":{"value":440,"modifier":"EXACT"}},"description":"ATP synthase alpha subunit C-terminal","evidences":[{"evidenceCode":"ECO:0000259","source":"Pfam","id":"PF00306"}]},{"type":"Site","location":{"start":{"value":337,"modifier":"EXACT"},"end":{"value":337,"modifier":"EXACT"}},"description":"Required for activity","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU10106"}]},{"type":"Non-terminal residue","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":1,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ABV31270.1"}]},{"type":"Non-terminal residue","location":{"start":{"value":441,"modifier":"EXACT"},"end":{"value":441,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ABV31270.1"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023310"}],"id":"KW-0066","category":"Biological process","name":"ATP synthesis"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022840"}],"id":"KW-0067","category":"Ligand","name":"ATP-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022475"}],"id":"KW-1003","category":"Cellular component","name":"Cell membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023196"}],"id":"KW-0139","category":"Cellular component","name":"CF(1)"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022781"}],"id":"KW-0375","category":"Biological process","name":"Hydrogen ion transport"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023065"}],"id":"KW-0406","category":"Biological process","name":"Ion transport"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023136"}],"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022741"}],"id":"KW-0547","category":"Ligand","name":"Nucleotide-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022967"}],"id":"KW-1278","category":"Molecular function","name":"Translocase"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022448"}],"id":"KW-0813","category":"Biological process","name":"Transport"}],"references":[{"referenceNumber":1,"citation":{"id":"17978204","citationType":"journal article","authors":["Thompson C.C.","Thompson F.L.","Vicente A.C.","Swings J."],"citationCrossReferences":[{"database":"PubMed","id":"17978204"},{"database":"DOI","id":"10.1099/ijs.0.65223-0"}],"title":"Phylogenetic analysis of vibrios and related species by means of atpA gene sequences.","publicationDate":"2007","journal":"Int. J. Syst. Evol. Microbiol.","firstPage":"2480","lastPage":"2484","volume":"57"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ABV31270.1"}],"value":"LMG 17719","type":"STRAIN"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ABV31324.1"}],"value":"LMG 21416","type":"STRAIN"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ABV31328.1"}],"value":"LMG 21538","type":"STRAIN"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ABV31270.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"EF601247","properties":[{"key":"ProteinId","value":"ABV31270.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"EF601301","properties":[{"key":"ProteinId","value":"ABV31324.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"EF601305","properties":[{"key":"ProteinId","value":"ABV31328.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"AlphaFoldDB","id":"A8S701","properties":[{"key":"Description","value":"-"}]},{"database":"GO","id":"GO:0045259","properties":[{"key":"GoTerm","value":"C:proton-transporting ATP synthase complex"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0043531","properties":[{"key":"GoTerm","value":"F:ADP binding"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:0005524","properties":[{"key":"GoTerm","value":"F:ATP binding"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0046933","properties":[{"key":"GoTerm","value":"F:proton-transporting ATP synthase activity, rotational mechanism"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"CDD","id":"cd18113","properties":[{"key":"EntryName","value":"ATP-synt_F1_alpha_C"},{"key":"MatchStatus","value":"1"}]},{"database":"CDD","id":"cd18116","properties":[{"key":"EntryName","value":"ATP-synt_F1_alpha_N"},{"key":"MatchStatus","value":"1"}]},{"database":"CDD","id":"cd01132","properties":[{"key":"EntryName","value":"F1-ATPase_alpha_CD"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.150.20:FF:000001","properties":[{"key":"EntryName","value":"ATP synthase subunit alpha"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.40.50.300:FF:000002","properties":[{"key":"EntryName","value":"ATP synthase subunit alpha"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.40.30.20","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.20.150.20","properties":[{"key":"EntryName","value":"ATP synthase alpha/beta chain, C-terminal domain"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.40.50.300","properties":[{"key":"EntryName","value":"P-loop containing nucleotide triphosphate hydrolases"},{"key":"MatchStatus","value":"1"}]},{"database":"HAMAP","id":"MF_01346","properties":[{"key":"EntryName","value":"ATP_synth_alpha_bact"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR023366","properties":[{"key":"EntryName","value":"ATP_synth_asu-like_sf"}]},{"database":"InterPro","id":"IPR000793","properties":[{"key":"EntryName","value":"ATP_synth_asu_C"}]},{"database":"InterPro","id":"IPR038376","properties":[{"key":"EntryName","value":"ATP_synth_asu_C_sf"}]},{"database":"InterPro","id":"IPR033732","properties":[{"key":"EntryName","value":"ATP_synth_F1_a_nt-bd_dom"}]},{"database":"InterPro","id":"IPR005294","properties":[{"key":"EntryName","value":"ATP_synth_F1_asu"}]},{"database":"InterPro","id":"IPR020003","properties":[{"key":"EntryName","value":"ATPase_a/bsu_AS"}]},{"database":"InterPro","id":"IPR004100","properties":[{"key":"EntryName","value":"ATPase_F1/V1/A1_a/bsu_N"}]},{"database":"InterPro","id":"IPR036121","properties":[{"key":"EntryName","value":"ATPase_F1/V1/A1_a/bsu_N_sf"}]},{"database":"InterPro","id":"IPR000194","properties":[{"key":"EntryName","value":"ATPase_F1/V1/A1_a/bsu_nucl-bd"}]},{"database":"InterPro","id":"IPR027417","properties":[{"key":"EntryName","value":"P-loop_NTPase"}]},{"database":"NCBIfam","id":"TIGR00962","properties":[{"key":"EntryName","value":"atpA"},{"key":"MatchStatus","value":"1"}]},{"database":"NCBIfam","id":"NF009884","properties":[{"key":"EntryName","value":"PRK13343.1"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR48082","properties":[{"key":"EntryName","value":"ATP SYNTHASE SUBUNIT ALPHA, MITOCHONDRIAL"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR48082:SF2","properties":[{"key":"EntryName","value":"ATP SYNTHASE SUBUNIT ALPHA, MITOCHONDRIAL"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00006","properties":[{"key":"EntryName","value":"ATP-synt_ab"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00306","properties":[{"key":"EntryName","value":"ATP-synt_ab_C"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF02874","properties":[{"key":"EntryName","value":"ATP-synt_ab_N"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF47917","properties":[{"key":"EntryName","value":"C-terminal domain of alpha and beta subunits of F1 ATP synthase"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF50615","properties":[{"key":"EntryName","value":"N-terminal domain of alpha and beta subunits of F1 ATP synthase"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF52540","properties":[{"key":"EntryName","value":"P-loop containing nucleoside triphosphate hydrolases"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00152","properties":[{"key":"EntryName","value":"ATPASE_ALPHA_BETA"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"GIIRIHGLADAMQGEMIELPGNRFALALNLERDSVGAVVMGPYADLQEGMKVTGTGRILEVPVGPELLGRVVNTLGEPIDGKGPINASLTSPVEVIAPGVIARQSVDQPVQTGYKAVDSMIPIGRGQRELIIGDRQTGKTALAIDAIINQKNSGIYSIYVAIGQKASTIANVVRKLEEHDALKNTIVVVASASEAAALQYLAPYAGCAMGEYFRDRGEDALIVYDDLSKQAVAYRQISLLLRRPPGREAFPGDVFYLHSRLLERAARVNADYVEKFTNGEVTGKTGSLTALPIIETQAGDVSAFVPTNVISITDGQIFLQTELFNAGIRPAVDPGISVSRVGGAAQTKIIKKLSGGIRTALAQYRELAAFAQFSSDLDEATKKQLDHGQKVTELMKQKQYAPMSVFEQGLMIFAAEKGYLSDIELNKLADFESALLAYAKG","length":441,"molWeight":47308,"crc64":"AB6AA6996A9D1BB8","md5":"A15823A72F067487723F1AEA7B51CEF4"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"CATALYTIC ACTIVITY":1,"SUBUNIT":1,"SUBCELLULAR LOCATION":1,"SIMILARITY":1},"countByFeatureType":{"Domain":3,"Site":1,"Non-terminal residue":2},"uniParcId":"UPI00015F3F39"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"F7IZI6","uniProtkbId":"F7IZI6_GRIHO","entryAudit":{"firstPublicDate":"2011-09-21","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2011-09-21","entryVersion":36,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Grimontia hollisae","commonName":"Vibrio hollisae","taxonId":673,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"BAK39964.1"}],"lineage":["Bacteria","Pseudomonadati","Pseudomonadota","Gammaproteobacteria","Vibrionales","Vibrionaceae","Grimontia"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00012653"}],"value":"microbial collagenase"},"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00012653"}],"value":"3.4.24.3"}]}},"comments":[{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"Digestion of native collagen in the triple helical region at Xaa-|-Gly bonds. With synthetic peptides, a preference is shown for Gly at P3 and P1', Pro and Ala at P2 and P2', and hydroxyproline, Ala or Arg at P3'.","ecNumber":"3.4.24.3","evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00000424"}]}},{"commentType":"COFACTOR","cofactors":[{"name":"Zn(2+)","evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00001947"}],"cofactorCrossReference":{"database":"ChEBI","id":"CHEBI:29105"}}]},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004613"}],"value":"Secreted","id":"SL-0243"}}]}],"features":[{"type":"Signal","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":21,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}]},{"type":"Chain","location":{"start":{"value":22,"modifier":"EXACT"},"end":{"value":767,"modifier":"EXACT"}},"description":"microbial collagenase","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"featureId":"PRO_5003355953"},{"type":"Domain","location":{"start":{"value":92,"modifier":"EXACT"},"end":{"value":271,"modifier":"EXACT"}},"description":"Peptidase M9 collagenase N-terminal","evidences":[{"evidenceCode":"ECO:0000259","source":"Pfam","id":"PF08453"}]},{"type":"Region","location":{"start":{"value":621,"modifier":"EXACT"},"end":{"value":647,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":624,"modifier":"EXACT"},"end":{"value":646,"modifier":"EXACT"}},"description":"Gly residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Active site","location":{"start":{"value":493,"modifier":"EXACT"},"end":{"value":493,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR602169-1"}]},{"type":"Binding site","location":{"start":{"value":173,"modifier":"EXACT"},"end":{"value":173,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29108"}],"evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7XEB"},{"evidenceCode":"ECO:0007829","source":"PDB","id":"8JT1"}],"ligand":{"name":"Ca(2+)","id":"ChEBI:CHEBI:29108","label":"1"}},{"type":"Binding site","location":{"start":{"value":173,"modifier":"EXACT"},"end":{"value":173,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29108"}],"evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7WSS"}],"ligand":{"name":"Ca(2+)","id":"ChEBI:CHEBI:29108","label":"2"}},{"type":"Binding site","location":{"start":{"value":176,"modifier":"EXACT"},"end":{"value":176,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29108"}],"evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8JT1"}],"ligand":{"name":"Ca(2+)","id":"ChEBI:CHEBI:29108","label":"1"}},{"type":"Binding site","location":{"start":{"value":179,"modifier":"EXACT"},"end":{"value":179,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29108"}],"evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7XEB"},{"evidenceCode":"ECO:0007829","source":"PDB","id":"8JT1"}],"ligand":{"name":"Ca(2+)","id":"ChEBI:CHEBI:29108","label":"1"}},{"type":"Binding site","location":{"start":{"value":179,"modifier":"EXACT"},"end":{"value":179,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29108"}],"evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7WSS"}],"ligand":{"name":"Ca(2+)","id":"ChEBI:CHEBI:29108","label":"2"}},{"type":"Binding site","location":{"start":{"value":391,"modifier":"EXACT"},"end":{"value":391,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29108"}],"evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8JT1"}],"ligand":{"name":"Ca(2+)","id":"ChEBI:CHEBI:29108","label":"3"}},{"type":"Binding site","location":{"start":{"value":436,"modifier":"EXACT"},"end":{"value":436,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29108"}],"evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7WSS"},{"evidenceCode":"ECO:0007829","source":"PDB","id":"8JT1"}],"ligand":{"name":"Ca(2+)","id":"ChEBI:CHEBI:29108","label":"3"}},{"type":"Binding site","location":{"start":{"value":461,"modifier":"EXACT"},"end":{"value":461,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29108"}],"evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7WSS"},{"evidenceCode":"ECO:0007829","source":"PDB","id":"7XEB"}],"ligand":{"name":"Ca(2+)","id":"ChEBI:CHEBI:29108","label":"4"}},{"type":"Binding site","location":{"start":{"value":477,"modifier":"EXACT"},"end":{"value":477,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29108"}],"evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7XEB"}],"ligand":{"name":"Ca(2+)","id":"ChEBI:CHEBI:29108","label":"3"}},{"type":"Binding site","location":{"start":{"value":492,"modifier":"EXACT"},"end":{"value":492,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29105"}],"evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7WSS"},{"evidenceCode":"ECO:0007829","source":"PDB","id":"7XEB"}],"ligand":{"name":"Zn(2+)","id":"ChEBI:CHEBI:29105"}},{"type":"Binding site","location":{"start":{"value":496,"modifier":"EXACT"},"end":{"value":496,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29105"}],"evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7WSS"},{"evidenceCode":"ECO:0007829","source":"PDB","id":"7XEB"}],"ligand":{"name":"Zn(2+)","id":"ChEBI:CHEBI:29105"}},{"type":"Binding site","location":{"start":{"value":500,"modifier":"EXACT"},"end":{"value":500,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29108"}],"evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7WSS"},{"evidenceCode":"ECO:0007829","source":"PDB","id":"8JT1"}],"ligand":{"name":"Ca(2+)","id":"ChEBI:CHEBI:29108","label":"4"}},{"type":"Binding site","location":{"start":{"value":504,"modifier":"EXACT"},"end":{"value":504,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29108"}],"evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7WSS"},{"evidenceCode":"ECO:0007829","source":"PDB","id":"7XEB"}],"ligand":{"name":"Ca(2+)","id":"ChEBI:CHEBI:29108","label":"4"}},{"type":"Binding site","location":{"start":{"value":506,"modifier":"EXACT"},"end":{"value":506,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29108"}],"evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8JT1"}],"ligand":{"name":"Ca(2+)","id":"ChEBI:CHEBI:29108","label":"4"}},{"type":"Binding site","location":{"start":{"value":520,"modifier":"EXACT"},"end":{"value":520,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29105"}],"evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7WSS"},{"evidenceCode":"ECO:0007829","source":"PDB","id":"7XEB"}],"ligand":{"name":"Zn(2+)","id":"ChEBI:CHEBI:29105"}},{"type":"Binding site","location":{"start":{"value":538,"modifier":"EXACT"},"end":{"value":538,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29108"}],"evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7WSS"},{"evidenceCode":"ECO:0007829","source":"PDB","id":"8JT1"}],"ligand":{"name":"Ca(2+)","id":"ChEBI:CHEBI:29108","label":"5"}},{"type":"Binding site","location":{"start":{"value":541,"modifier":"EXACT"},"end":{"value":541,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29108"}],"evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7XEB"}],"ligand":{"name":"Ca(2+)","id":"ChEBI:CHEBI:29108","label":"5"}},{"type":"Binding site","location":{"start":{"value":543,"modifier":"EXACT"},"end":{"value":543,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29108"}],"evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7XEB"},{"evidenceCode":"ECO:0007829","source":"PDB","id":"8JT1"}],"ligand":{"name":"Ca(2+)","id":"ChEBI:CHEBI:29108","label":"5"}},{"type":"Disulfide bond","location":{"start":{"value":92,"modifier":"EXACT"},"end":{"value":116,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7WSS"},{"evidenceCode":"ECO:0007829","source":"PDB","id":"7XEB"}]},{"type":"Disulfide bond","location":{"start":{"value":358,"modifier":"EXACT"},"end":{"value":364,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7WSS"},{"evidenceCode":"ECO:0007829","source":"PDB","id":"7XEB"}]},{"type":"Disulfide bond","location":{"start":{"value":381,"modifier":"EXACT"},"end":{"value":401,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7WSS"},{"evidenceCode":"ECO:0007829","source":"PDB","id":"7XEB"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7WSS"},{"evidenceCode":"ECO:0007829","source":"PDB","id":"7XEB"}],"id":"KW-0002","category":"Technical term","name":"3D-structure"},{"evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7WSS"},{"evidenceCode":"ECO:0007829","source":"PDB","id":"7XEB"}],"id":"KW-0106","category":"Ligand","name":"Calcium"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022801"}],"id":"KW-0378","category":"Molecular function","name":"Hydrolase"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022723"},{"evidenceCode":"ECO:0007829","source":"PDB","id":"7WSS"}],"id":"KW-0479","category":"Ligand","name":"Metal-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023049"}],"id":"KW-0482","category":"Molecular function","name":"Metalloprotease"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022670"}],"id":"KW-0645","category":"Molecular function","name":"Protease"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022525"}],"id":"KW-0964","category":"Cellular component","name":"Secreted"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022729"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"id":"KW-0732","category":"Domain","name":"Signal"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022833"},{"evidenceCode":"ECO:0007829","source":"PDB","id":"7WSS"}],"id":"KW-0862","category":"Ligand","name":"Zinc"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023145"}],"id":"KW-0865","category":"PTM","name":"Zymogen"}],"references":[{"referenceNumber":1,"citation":{"id":"21515782","citationType":"journal article","authors":["Teramura N.","Tanaka K.","Iijima K.","Hayashida O.","Suzuki K.","Hattori S.","Irie S."],"citationCrossReferences":[{"database":"PubMed","id":"21515782"},{"database":"DOI","id":"10.1128/JB.01528-10"}],"title":"Cloning of a Novel Collagenase Gene from the Gram-Negative Bacterium Grimontia (Vibrio) hollisae 1706B and Its Efficient Expression in Brevibacillus choshinensis.","publicationDate":"2011","journal":"J. Bacteriol.","firstPage":"3049","lastPage":"3056","volume":"193"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"BAK39964.1"}],"value":"1706B","type":"STRAIN"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"BAK39964.1"}]},{"referenceNumber":2,"citation":{"id":"35679897","citationType":"journal article","authors":["Ikeuchi T.","Yasumoto M.","Takita T.","Tanaka K.","Kusubata M.","Hayashida O.","Hattori S.","Mizutani K.","Mikami B.","Yasukawa K."],"citationCrossReferences":[{"database":"PubMed","id":"35679897"},{"database":"DOI","id":"10.1016/j.jbc.2022.102109"}],"title":"Crystal structure of Grimontia hollisae collagenase provides insights into its novel substrate specificity toward collagen.","publicationDate":"2022","journal":"J. Biol. Chem.","firstPage":"102109","lastPage":"102109","volume":"298"},"referencePositions":["X-RAY CRYSTALLOGRAPHY (2.19 ANGSTROMS) OF 88-646 IN COMPLEX WITH CA(2+) AND ZN(2+)","DISULFIDE BONDS"],"evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7WSS"},{"evidenceCode":"ECO:0007829","source":"PDB","id":"7XEB"}]},{"referenceNumber":3,"citation":{"id":"37698340","citationType":"journal article","authors":["Ueshima S.","Yasumoto M.","Kitagawa Y.","Akazawa K.","Takita T.","Tanaka K.","Hattori S.","Mizutani K.","Mikami B.","Yasukawa K."],"citationCrossReferences":[{"database":"PubMed","id":"37698340"},{"database":"DOI","id":"10.1002/1873-3468.14732"}],"title":"Insights into the catalytic mechanism of Grimontia hollisae collagenase through structural and mutational analyses.","publicationDate":"2023","journal":"FEBS Lett.","firstPage":"2473","lastPage":"2483","volume":"597"},"referencePositions":["X-RAY CRYSTALLOGRAPHY (2.00 ANGSTROMS) OF 88-646 IN COMPLEX WITH CA(2+) AND ZN(2+)","DISULFIDE BONDS"],"evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8JT1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AB600550","properties":[{"key":"ProteinId","value":"BAK39964.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"PDB","id":"7WSS","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.19 A"},{"key":"Chains","value":"A/B=88-646"}]},{"database":"PDB","id":"7XEB","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.39 A"},{"key":"Chains","value":"A/B=88-646"}]},{"database":"PDB","id":"8JT1","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.00 A"},{"key":"Chains","value":"A/B=88-646"}]},{"database":"AlphaFoldDB","id":"F7IZI6","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"F7IZI6","properties":[{"key":"Description","value":"-"}]},{"database":"MEROPS","id":"M09.001","properties":[{"key":"Description","value":"-"}]},{"database":"BRENDA","id":"3.4.24.3","properties":[{"key":"OrganismId","value":"9343"}]},{"database":"GO","id":"GO:0005576","properties":[{"key":"GoTerm","value":"C:extracellular region"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0004222","properties":[{"key":"GoTerm","value":"F:metalloendopeptidase activity"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-EC"}]},{"database":"GO","id":"GO:0008270","properties":[{"key":"GoTerm","value":"F:zinc ion binding"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0006508","properties":[{"key":"GoTerm","value":"P:proteolysis"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"Gene3D","id":"1.10.390.20","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.60.120.380","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.40.30.160","properties":[{"key":"EntryName","value":"Collagenase ColT, N-terminal domain"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR013661","properties":[{"key":"EntryName","value":"Peptidase_M9_N_dom"}]},{"database":"InterPro","id":"IPR002169","properties":[{"key":"EntryName","value":"Peptidase_M9A/M9B"}]},{"database":"PANTHER","id":"PTHR13062","properties":[{"key":"EntryName","value":"COLLAGENASE"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR13062:SF9","properties":[{"key":"EntryName","value":"MICROBIAL COLLAGENASE"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF01752","properties":[{"key":"EntryName","value":"Peptidase_M9"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF08453","properties":[{"key":"EntryName","value":"Peptidase_M9_N"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR00931","properties":[{"key":"EntryName","value":"MICOLLPTASE"}]}],"sequence":{"value":"MELKALALTVSALLVGQSVYASEVFAHPGMPVQQKLQPNLLQQSTRLQPEQHIHGLERTDRQYRPTDATQQPEPPTLLKRQVSVQQDAVEQCDLSQFQTTSSNQLMAAIRQQGASCVNALFSADTGVQEAAFSSNHMYNVAQYTRTLAQQYAGGGSDELEALYLYLRAGYYAEFYNSNITFLSWVTPAVKGAVDAFVQNAHFYDNGDAHGKVLNEVIITMDSAGLQHAYLDVVTQWLTRWNAQYAEHWYMRNAVNGVFTLLFGGQWNNQYTSLIGEQTALVTALQAFALDRTKVNSPTEFMAANAARELGRLARYTDATIAPKVTEGLTAIFGQYPSYGDGDAIWLGAADTASYYADCSQFNICGFEDALRDAALNQTFICSDTIKIRSQDMSQAQHLAACDKMAYEESFFHTTLETGNQPVADDHNTQLQVNIFNSDTDYGKYAGPIFGIDTNNGGMYLEGNPANVGNIPNFIAYEASYANPDHFVWNLEHEYVHYLDGRFNMYGDFGTPTELVVWWSEGVAEYVSRVNDNPQAIATIQDGSTYTLAQVFDTTYDGFDVDRIYRWGYLAVRFMFERHPDEVQRMLSATRQGRWAEYKAIISGWANQYQSEFAQWTEALAKGDSGAGNGEGTGSGNEGGGESGGNTGLPENCAVLPKISDGRLALDEAACLADTASASDVLWFSIPAVSEYQTIAITAGNGTGDLTLEYSNLNWPDGTNVQASSANMGNSECIILEHQANYWGYLKVSGSFENAALLVEAGSNQCRQ","length":767,"molWeight":84407,"crc64":"C8F22AC5B21621FF","md5":"B3F4242D9BF95F41D0021CC028B06B55"},"extraAttributes":{"countByCommentType":{"CATALYTIC ACTIVITY":1,"COFACTOR":1,"SUBCELLULAR LOCATION":1},"countByFeatureType":{"Signal":1,"Chain":1,"Domain":1,"Region":1,"Compositional bias":1,"Active site":1,"Binding site":18,"Disulfide bond":3},"uniParcId":"UPI00020F3B40"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"Q4H465","uniProtkbId":"Q4H465_GRIHO","entryAudit":{"firstPublicDate":"2005-08-30","lastAnnotationUpdateDate":"2026-11-04","lastSequenceUpdateDate":"2005-08-30","entryVersion":88,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Grimontia hollisae","commonName":"Vibrio hollisae","taxonId":673,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"BAE15999.1"}],"lineage":["Bacteria","Pseudomonadati","Pseudomonadota","Gammaproteobacteria","Vibrionales","Vibrionaceae","Grimontia"]},"proteinExistence":"3: Inferred from homology","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"BAE15999.1"},{"evidenceCode":"ECO:0000313","source":"EMBL","id":"STO57545.1"}],"value":"ATP-binding protein"},"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"STO57545.1"}],"value":"3.6.3.34"}]}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"BAE15999.1"}],"value":"hatC"},"synonyms":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"STO57545.1"}],"value":"fhuC"}],"orfNames":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"STO57545.1"}],"value":"NCTC11645_01937"}]}],"comments":[{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004202"}],"value":"Cell membrane","id":"SL-0039"},"topology":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004202"}],"value":"Peripheral membrane protein","id":"SL-9903"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00005417"}],"value":"Belongs to the ABC transporter superfamily"}],"commentType":"SIMILARITY"}],"features":[{"type":"Domain","location":{"start":{"value":2,"modifier":"EXACT"},"end":{"value":238,"modifier":"EXACT"}},"description":"ABC transporter","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50893"}]},{"type":"Binding site","location":{"start":{"value":34,"modifier":"EXACT"},"end":{"value":41,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:30616"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00434"}],"ligand":{"name":"ATP","id":"ChEBI:CHEBI:30616"}}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022840"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00434"}],"id":"KW-0067","category":"Ligand","name":"ATP-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022475"}],"id":"KW-1003","category":"Cellular component","name":"Cell membrane"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"STO57545.1"}],"id":"KW-0378","category":"Molecular function","name":"Hydrolase"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023065"}],"id":"KW-0406","category":"Biological process","name":"Ion transport"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023004"}],"id":"KW-0408","category":"Ligand","name":"Iron"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022496"}],"id":"KW-0410","category":"Biological process","name":"Iron transport"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023136"}],"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022741"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00434"}],"id":"KW-0547","category":"Ligand","name":"Nucleotide-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022448"}],"id":"KW-0813","category":"Biological process","name":"Transport"}],"references":[{"referenceNumber":1,"citation":{"id":"16809025","citationType":"journal article","authors":["Suzuki K.","Tanabe T.","Moon Y.-H.","Funahashi T.","Nakao H.","Narimatsu S.","Yamamoto S."],"citationCrossReferences":[{"database":"PubMed","id":"16809025"},{"database":"DOI","id":"10.1016/j.resmic.2006.05.001"}],"title":"Identification and transcriptional organization of aerobactin transport and biosynthesis cluster genes of Vibrio hollisae.","publicationDate":"2006","journal":"Res. Microbiol.","firstPage":"730","lastPage":"740","volume":"157"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"BAE15999.1"}],"value":"ATCC 33564","type":"STRAIN"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"BAE15999.1"}]},{"referenceNumber":2,"citation":{"id":"CI-AB4PR2KKK46L9","citationType":"submission","authoringGroup":["Pathogen Informatics"],"authors":["Doyle S."],"publicationDate":"JUN-2018","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"STO57545.1"}],"value":"NCTC11645","type":"STRAIN"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"STO57545.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AB199785","properties":[{"key":"ProteinId","value":"BAE15999.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"UGHD01000002","properties":[{"key":"ProteinId","value":"STO57545.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"RefSeq","id":"WP_005505278.1","properties":[{"key":"NucleotideSequenceId","value":"NZ_CABMOB010000001.1"}]},{"database":"AlphaFoldDB","id":"Q4H465","properties":[{"key":"Description","value":"-"}]},{"database":"STRING","id":"673.AL542_16565","properties":[{"key":"Description","value":"-"}]},{"database":"GeneID","id":"58897567","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"gho:AL542_16565","properties":[{"key":"Description","value":"-"}]},{"database":"GO","id":"GO:0005886","properties":[{"key":"GoTerm","value":"C:plasma membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0005524","properties":[{"key":"GoTerm","value":"F:ATP binding"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniRule"}]},{"database":"GO","id":"GO:0016887","properties":[{"key":"GoTerm","value":"F:ATP hydrolysis activity"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"CDD","id":"cd03214","properties":[{"key":"EntryName","value":"ABC_Iron-Siderophores_B12_Hemin"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.40.50.300:FF:000134","properties":[{"key":"EntryName","value":"Iron-enterobactin ABC transporter ATP-binding protein"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.40.50.300","properties":[{"key":"EntryName","value":"P-loop containing nucleotide triphosphate hydrolases"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR003593","properties":[{"key":"EntryName","value":"AAA+_ATPase"}]},{"database":"InterPro","id":"IPR003439","properties":[{"key":"EntryName","value":"ABC_transporter-like_ATP-bd"}]},{"database":"InterPro","id":"IPR017871","properties":[{"key":"EntryName","value":"ABC_transporter-like_CS"}]},{"database":"InterPro","id":"IPR027417","properties":[{"key":"EntryName","value":"P-loop_NTPase"}]},{"database":"InterPro","id":"IPR051535","properties":[{"key":"EntryName","value":"Siderophore_ABC-ATPase"}]},{"database":"PANTHER","id":"PTHR42771","properties":[{"key":"EntryName","value":"IRON(3+)-HYDROXAMATE IMPORT ATP-BINDING PROTEIN FHUC"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR42771:SF2","properties":[{"key":"EntryName","value":"IRON(3+)-HYDROXAMATE IMPORT ATP-BINDING PROTEIN FHUC"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00005","properties":[{"key":"EntryName","value":"ABC_tran"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00382","properties":[{"key":"EntryName","value":"AAA"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF52540","properties":[{"key":"EntryName","value":"P-loop containing nucleoside triphosphate hydrolases"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00211","properties":[{"key":"EntryName","value":"ABC_TRANSPORTER_1"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50893","properties":[{"key":"EntryName","value":"ABC_TRANSPORTER_2"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MFSLNAVSYSVPEKTILHPVSLTIPAGRITTLLGHNGSGKSTLIKLLSRNILPSSGDIQLAGMPLSAFSSRDYSRRVAYLPQDPPITDSITVYELVRLGRYPWKGALGRYDEHDDDIIAQAMNAVGVSTLADRFVSTLSGGERQRVWVAMLLAQQSECLLLDEPTSALDVAHQYELLSLIRKLNRERNLTVVMVLHDINLAARYSDTLVALHSGKIMAQGDAQSLMSQPILEAIYDIPLGFFPHPENGQPIAYVR","length":255,"molWeight":28082,"crc64":"74AC2443970624EC","md5":"51B00D0D582C0B9A8B693D0C0827341A"},"extraAttributes":{"countByCommentType":{"SUBCELLULAR LOCATION":1,"SIMILARITY":1},"countByFeatureType":{"Domain":1,"Binding site":1},"uniParcId":"UPI000056282A"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"Q5W5A6","uniProtkbId":"Q5W5A6_GRIHO","entryAudit":{"firstPublicDate":"2004-12-07","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2004-12-07","entryVersion":91,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Grimontia hollisae","commonName":"Vibrio hollisae","taxonId":673,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"CAE54414.1"}],"lineage":["Bacteria","Pseudomonadati","Pseudomonadota","Gammaproteobacteria","Vibrionales","Vibrionaceae","Grimontia"]},"proteinExistence":"3: Inferred from homology","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00015553"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000526"}],"value":"Protein RecA"}},"alternativeNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000526"}],"value":"Recombinase A"}}],"flag":"Fragment"},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"CAE54414.1"}],"value":"recA"}}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000526"}],"value":"Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00009391"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU004527"}],"value":"Belongs to the RecA family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Domain","location":{"start":{"value":15,"modifier":"EXACT"},"end":{"value":174,"modifier":"EXACT"}},"description":"RecA family profile 1","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50162"}]},{"type":"Domain","location":{"start":{"value":179,"modifier":"EXACT"},"end":{"value":252,"modifier":"EXACT"}},"description":"RecA family profile 2","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50163"}]},{"type":"Non-terminal residue","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":1,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"CAE54414.1"}]},{"type":"Non-terminal residue","location":{"start":{"value":255,"modifier":"EXACT"},"end":{"value":255,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"CAE54414.1"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022840"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU004527"}],"id":"KW-0067","category":"Ligand","name":"ATP-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022763"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU004527"}],"id":"KW-0227","category":"Biological process","name":"DNA damage"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023172"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU004527"}],"id":"KW-0233","category":"Biological process","name":"DNA recombination"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023204"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000526"}],"id":"KW-0234","category":"Biological process","name":"DNA repair"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023125"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU004527"}],"id":"KW-0238","category":"Molecular function","name":"DNA-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022741"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU004527"}],"id":"KW-0547","category":"Ligand","name":"Nucleotide-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023236"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000526"}],"id":"KW-0742","category":"Biological process","name":"SOS response"}],"references":[{"referenceNumber":1,"citation":{"id":"15143042","citationType":"journal article","authors":["Thompson C.C.","Thompson F.L.","Vandemeulebroecke K.","Hoste B.","Dawyndt P.","Swings J."],"citationCrossReferences":[{"database":"PubMed","id":"15143042"},{"database":"DOI","id":"10.1099/ijs.0.02963-0"}],"title":"Use of recA as an alternative phylogenetic marker in the family Vibrionaceae.","publicationDate":"2004","journal":"Int. J. Syst. Evol. Microbiol.","firstPage":"919","lastPage":"924","volume":"54"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"CAE54414.1"}],"value":"Type strain: LMG 17719","type":"STRAIN"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"CAE54414.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AJ580906","properties":[{"key":"ProteinId","value":"CAE54414.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"AlphaFoldDB","id":"Q5W5A6","properties":[{"key":"Description","value":"-"}]},{"database":"GO","id":"GO:0005829","properties":[{"key":"GoTerm","value":"C:cytosol"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:0005524","properties":[{"key":"GoTerm","value":"F:ATP binding"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0140664","properties":[{"key":"GoTerm","value":"F:ATP-dependent DNA damage sensor activity"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0003697","properties":[{"key":"GoTerm","value":"F:single-stranded DNA binding"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0006281","properties":[{"key":"GoTerm","value":"P:DNA repair"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"CDD","id":"cd00983","properties":[{"key":"EntryName","value":"RecA"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.40.50.300:FF:000087","properties":[{"key":"EntryName","value":"Recombinase RecA"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.40.50.300","properties":[{"key":"EntryName","value":"P-loop containing nucleotide triphosphate hydrolases"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR003593","properties":[{"key":"EntryName","value":"AAA+_ATPase"}]},{"database":"InterPro","id":"IPR013765","properties":[{"key":"EntryName","value":"DNA_recomb/repair_RecA"}]},{"database":"InterPro","id":"IPR020584","properties":[{"key":"EntryName","value":"DNA_recomb/repair_RecA_CS"}]},{"database":"InterPro","id":"IPR027417","properties":[{"key":"EntryName","value":"P-loop_NTPase"}]},{"database":"InterPro","id":"IPR049428","properties":[{"key":"EntryName","value":"RecA-like_N"}]},{"database":"InterPro","id":"IPR020588","properties":[{"key":"EntryName","value":"RecA_ATP-bd"}]},{"database":"InterPro","id":"IPR020587","properties":[{"key":"EntryName","value":"RecA_monomer-monomer_interface"}]},{"database":"NCBIfam","id":"TIGR02012","properties":[{"key":"EntryName","value":"tigrfam_recA"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR45900:SF1","properties":[{"key":"EntryName","value":"MITOCHONDRIAL DNA REPAIR PROTEIN RECA HOMOLOG-RELATED"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR45900","properties":[{"key":"EntryName","value":"RECA"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00154","properties":[{"key":"EntryName","value":"RecA_N"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR00142","properties":[{"key":"EntryName","value":"RECA"}]},{"database":"SMART","id":"SM00382","properties":[{"key":"EntryName","value":"AAA"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF52540","properties":[{"key":"EntryName","value":"P-loop containing nucleoside triphosphate hydrolases"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00321","properties":[{"key":"EntryName","value":"RECA_1"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50162","properties":[{"key":"EntryName","value":"RECA_2"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50163","properties":[{"key":"EntryName","value":"RECA_3"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"GKGSIMRLGDDRTMDIETVSTGSLSLDIALGAGGLPYGRIVEIYGPESSGKTTLTLQVIAEAQKQGKTCAFIDAEHALDPIYARKLNVDIDNLLVSQPDTGEQALEIADALTRSGAVDVIIIDSVAALTPKAEIEGEMGDSHMGLQARMLSQAMRKLTANIKNSNTLMIFINQIRMKIGVMFGNPETTTGGNALKFYASVRLDIRRIGSIKEGDEVVGNDTRVKVVKNKIAAPFKQAEFQILYGEGINLYGELID","length":255,"molWeight":27461,"crc64":"5C88A4CA2CF35708","md5":"DABF3E581D5B24E1F3AD1D4BDFADED19"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"SIMILARITY":1},"countByFeatureType":{"Domain":2,"Non-terminal residue":2},"uniParcId":"UPI0000452619"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"Q9AMF9","uniProtkbId":"Q9AMF9_GRIHO","entryAudit":{"firstPublicDate":"2001-06-01","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2001-06-01","entryVersion":83,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Grimontia hollisae","commonName":"Vibrio hollisae","taxonId":673,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAK07461.1"}],"lineage":["Bacteria","Pseudomonadati","Pseudomonadota","Gammaproteobacteria","Vibrionales","Vibrionaceae","Grimontia"]},"proteinExistence":"3: Inferred from homology","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000560"}],"value":"50S ribosomal protein L20"}},"flag":"Fragment"},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAK07461.1"}],"value":"rplT"}}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000560"}],"value":"Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00007698"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000560"}],"value":"Belongs to the bacterial ribosomal protein bL20 family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Non-terminal residue","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":1,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAK07461.1"}]},{"type":"Non-terminal residue","location":{"start":{"value":102,"modifier":"EXACT"},"end":{"value":102,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAK07461.1"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023274"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000560"}],"id":"KW-0687","category":"Molecular function","name":"Ribonucleoprotein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022980"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000560"}],"id":"KW-0689","category":"Molecular function","name":"Ribosomal protein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022884"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000560"}],"id":"KW-0694","category":"Molecular function","name":"RNA-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022730"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000560"}],"id":"KW-0699","category":"Molecular function","name":"rRNA-binding"}],"references":[{"referenceNumber":1,"citation":{"id":"11209061","citationType":"journal article","authors":["Rowe-Magnus D.A.","Guerout A.M.","Ploncard P.","Dychinco B.","Davies J.","Mazel D."],"citationCrossReferences":[{"database":"PubMed","id":"11209061"},{"database":"DOI","id":"10.1073/pnas.98.2.652"}],"title":"The evolutionary history of chromosomal super-integrons provides an ancestry for multi-resistant integrons.","publicationDate":"2001","journal":"Proc. Natl. Acad. Sci. U.S.A.","firstPage":"652","lastPage":"657","volume":"98"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAK07461.1"}],"value":"CIP 101886T","type":"STRAIN"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAK07461.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AF324944","properties":[{"key":"ProteinId","value":"AAK07461.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"AlphaFoldDB","id":"Q9AMF9","properties":[{"key":"Description","value":"-"}]},{"database":"GO","id":"GO:0005840","properties":[{"key":"GoTerm","value":"C:ribosome"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0019843","properties":[{"key":"GoTerm","value":"F:rRNA binding"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0003735","properties":[{"key":"GoTerm","value":"F:structural constituent of ribosome"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0006412","properties":[{"key":"GoTerm","value":"P:translation"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"CDD","id":"cd07026","properties":[{"key":"EntryName","value":"Ribosomal_L20"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.10.1900.20:FF:000001","properties":[{"key":"EntryName","value":"50S ribosomal protein L20"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"6.10.160.10","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.10.1900.20","properties":[{"key":"EntryName","value":"Ribosomal protein L20"},{"key":"MatchStatus","value":"1"}]},{"database":"HAMAP","id":"MF_00382","properties":[{"key":"EntryName","value":"Ribosomal_bL20"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR005813","properties":[{"key":"EntryName","value":"Ribosomal_bL20"}]},{"database":"InterPro","id":"IPR049946","properties":[{"key":"EntryName","value":"RIBOSOMAL_L20_CS"}]},{"database":"InterPro","id":"IPR035566","properties":[{"key":"EntryName","value":"Ribosomal_protein_bL20_C"}]},{"database":"NCBIfam","id":"TIGR01032","properties":[{"key":"EntryName","value":"rplT_bact"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR10986","properties":[{"key":"EntryName","value":"39S RIBOSOMAL PROTEIN L20"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00453","properties":[{"key":"EntryName","value":"Ribosomal_L20"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR00062","properties":[{"key":"EntryName","value":"RIBOSOMALL20"}]},{"database":"SUPFAM","id":"SSF74731","properties":[{"key":"EntryName","value":"Ribosomal protein L20"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00937","properties":[{"key":"EntryName","value":"RIBOSOMAL_L20"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"PRVKRGVQARARHKKVLKQAKGYYGARSRVYRVAFQAVTKAGQYAYRDRRQKKRQFRQLWIARINAAARQNGMSYSRFINGLKKASIEIDRKILADIAVFDK","length":102,"molWeight":11928,"crc64":"C39EF7DBEE83B99A","md5":"24A4A5490FC4F37423D97600A6632C94"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"SIMILARITY":1},"countByFeatureType":{"Non-terminal residue":2},"uniParcId":"UPI00000BA28E"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"Q9S0W6","uniProtkbId":"Q9S0W6_GRIHO","entryAudit":{"firstPublicDate":"2000-05-01","lastAnnotationUpdateDate":"2026-11-04","lastSequenceUpdateDate":"2000-05-01","entryVersion":111,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Grimontia hollisae","commonName":"Vibrio hollisae","taxonId":673,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"BAA86938.1"}],"lineage":["Bacteria","Pseudomonadati","Pseudomonadota","Gammaproteobacteria","Vibrionales","Vibrionaceae","Grimontia"]},"proteinExistence":"3: Inferred from homology","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00019166"}],"value":"DNA gyrase subunit B"},"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00012895"}],"value":"5.6.2.2"}]},"flag":"Fragment"},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"BAA86938.1"}],"value":"gyrB"}}],"comments":[{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"ATP-dependent breakage, passage and rejoining of double-stranded DNA.","ecNumber":"5.6.2.2","evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00000185"}]}},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00010708"}],"value":"Belongs to the type II topoisomerase GyrB family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Domain","location":{"start":{"value":328,"modifier":"EXACT"},"end":{"value":420,"modifier":"EXACT"}},"description":"Toprim","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50880"}]},{"type":"Site","location":{"start":{"value":359,"modifier":"EXACT"},"end":{"value":359,"modifier":"EXACT"}},"description":"Interaction with DNA","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00995"}]},{"type":"Site","location":{"start":{"value":362,"modifier":"EXACT"},"end":{"value":362,"modifier":"EXACT"}},"description":"Interaction with DNA","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00995"}]},{"type":"Non-terminal residue","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":1,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"BAA86938.1"}]},{"type":"Non-terminal residue","location":{"start":{"value":420,"modifier":"EXACT"},"end":{"value":420,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"BAA86938.1"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022840"}],"id":"KW-0067","category":"Ligand","name":"ATP-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023125"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00995"}],"id":"KW-0238","category":"Molecular function","name":"DNA-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023235"}],"id":"KW-0413","category":"Molecular function","name":"Isomerase"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022741"}],"id":"KW-0547","category":"Ligand","name":"Nucleotide-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023029"}],"id":"KW-0799","category":"Molecular function","name":"Topoisomerase"}],"references":[{"referenceNumber":1,"citation":{"id":"10919814","citationType":"journal article","authors":["Vuddhakul V.","Nakai T.","Matsumoto C.","Oh T.","Nishino T.","Chen C.H.","Nishibuchi M.","Okuda J."],"citationCrossReferences":[{"database":"PubMed","id":"10919814"},{"database":"DOI","id":"10.1128/AEM.66.8.3506-3514.2000"}],"title":"Analysis of gyrB and toxR gene sequences of Vibrio hollisae and development of gyrB- and toxR-targeted PCR methods for isolation of V. hollisae from the environment and its identification.","publicationDate":"2000","journal":"Appl. Environ. Microbiol.","firstPage":"3506","lastPage":"3514","volume":"66"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"BAA86938.1"}],"value":"89A 1962","type":"STRAIN"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"BAA86938.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AB027462","properties":[{"key":"ProteinId","value":"BAA86938.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"AlphaFoldDB","id":"Q9S0W6","properties":[{"key":"Description","value":"-"}]},{"database":"GO","id":"GO:0005524","properties":[{"key":"GoTerm","value":"F:ATP binding"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0003677","properties":[{"key":"GoTerm","value":"F:DNA binding"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniRule"}]},{"database":"GO","id":"GO:0003918","properties":[{"key":"GoTerm","value":"F:DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-EC"}]},{"database":"GO","id":"GO:0006265","properties":[{"key":"GoTerm","value":"P:DNA topological change"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"CDD","id":"cd00822","properties":[{"key":"EntryName","value":"TopoII_Trans_DNA_gyrase"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.30.230.10:FF:000005","properties":[{"key":"EntryName","value":"DNA gyrase subunit B"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.30.230.10","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.40.50.670","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.30.565.10","properties":[{"key":"EntryName","value":"Histidine kinase-like ATPase, C-terminal domain"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR036890","properties":[{"key":"EntryName","value":"HATPase_C_sf"}]},{"database":"InterPro","id":"IPR020568","properties":[{"key":"EntryName","value":"Ribosomal_Su5_D2-typ_SF"}]},{"database":"InterPro","id":"IPR014721","properties":[{"key":"EntryName","value":"Ribsml_uS5_D2-typ_fold_subgr"}]},{"database":"InterPro","id":"IPR001241","properties":[{"key":"EntryName","value":"Topo_IIA"}]},{"database":"InterPro","id":"IPR013760","properties":[{"key":"EntryName","value":"Topo_IIA-like_dom_sf"}]},{"database":"InterPro","id":"IPR000565","properties":[{"key":"EntryName","value":"Topo_IIA_B"}]},{"database":"InterPro","id":"IPR013759","properties":[{"key":"EntryName","value":"Topo_IIA_B_C"}]},{"database":"InterPro","id":"IPR013506","properties":[{"key":"EntryName","value":"Topo_IIA_bsu_dom2"}]},{"database":"InterPro","id":"IPR018522","properties":[{"key":"EntryName","value":"TopoIIA_CS"}]},{"database":"InterPro","id":"IPR006171","properties":[{"key":"EntryName","value":"TOPRIM_dom"}]},{"database":"NCBIfam","id":"NF011501","properties":[{"key":"EntryName","value":"PRK14939.1"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR45866:SF1","properties":[{"key":"EntryName","value":"DNA GYRASE SUBUNIT B, MITOCHONDRIAL"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR45866","properties":[{"key":"EntryName","value":"DNA GYRASE/TOPOISOMERASE SUBUNIT B"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00204","properties":[{"key":"EntryName","value":"DNA_gyraseB"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF01751","properties":[{"key":"EntryName","value":"Toprim"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR01159","properties":[{"key":"EntryName","value":"DNAGYRASEB"}]},{"database":"PRINTS","id":"PR00418","properties":[{"key":"EntryName","value":"TPI2FAMILY"}]},{"database":"SMART","id":"SM00433","properties":[{"key":"EntryName","value":"TOP2c"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF55874","properties":[{"key":"EntryName","value":"ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF54211","properties":[{"key":"EntryName","value":"Ribosomal protein S5 domain 2-like"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF56719","properties":[{"key":"EntryName","value":"Type II DNA topoisomerase"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00177","properties":[{"key":"EntryName","value":"TOPOISOMERASE_II"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50880","properties":[{"key":"EntryName","value":"TOPRIM"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"EVIMTVLHAGGKFDDNSYKVSGGLHGVGVSVVNALSEKLELTIWRHGHVHQQIYRMGVPEKPLEVIGDTDETGTRIRFWPSDETFSDTTFHYDILAKRLRELSFLNSGVSIKLIDEREENKHDHFMYEGGIRAFVEHLNRNKTPIHPTVFHFEHEREDGVSVEVSMQWNDGFQENIYCFTNNIPQRDGGTHLAGFRAALTRTLNNFMDKEGYSKKAKAATSGDDAREGLTAVVSVKVPDPKFSSQTKDKLVSSEVKSAVESAMGEKLAEFLIENPQDSKIVCSKIIDAARAREAARKAREMTRRKGALDLAGLPGKLADCQEKDPALSELYIVEGDSAGGSAKQGRNRKNQAILPLKGKILNVEKARFDKMLSSQEVATLITALGCGIGRDEYNPDKLRYHSIIIMTDADVDGSHIRTLL","length":420,"molWeight":46711,"crc64":"8376F30B87E7C46C","md5":"7600BCF646FCF7ECD0F856039FA55739"},"extraAttributes":{"countByCommentType":{"CATALYTIC ACTIVITY":1,"SIMILARITY":1},"countByFeatureType":{"Domain":1,"Site":2,"Non-terminal residue":2},"uniParcId":"UPI00000B23C7"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A5A6V2","uniProtkbId":"A5A6V2_GRIHO","entryAudit":{"firstPublicDate":"2007-06-12","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2007-06-12","entryVersion":76,"sequenceVersion":1},"annotationScore":1.0,"organism":{"scientificName":"Grimontia hollisae","commonName":"Vibrio hollisae","taxonId":673,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"BAF62496.1"}],"lineage":["Bacteria","Pseudomonadati","Pseudomonadota","Gammaproteobacteria","Vibrionales","Vibrionaceae","Grimontia"]},"proteinExistence":"4: Predicted","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"BAF62496.1"}],"value":"DnaJ"}}],"flag":"Fragment"},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"BAF62496.1"}],"value":"dnaJ"}}],"features":[{"type":"Domain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":58,"modifier":"EXACT"}},"description":"J","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50076"}]},{"type":"Domain","location":{"start":{"value":122,"modifier":"EXACT"},"end":{"value":170,"modifier":"EXACT"}},"description":"CR-type","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS51188"}]},{"type":"Zinc finger","location":{"start":{"value":122,"modifier":"EXACT"},"end":{"value":170,"modifier":"EXACT"}},"description":"CR-type","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00546"}]},{"type":"Non-terminal residue","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":1,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"BAF62496.1"}]},{"type":"Non-terminal residue","location":{"start":{"value":170,"modifier":"EXACT"},"end":{"value":170,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"BAF62496.1"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023186"}],"id":"KW-0143","category":"Molecular function","name":"Chaperone"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022490"}],"id":"KW-0963","category":"Cellular component","name":"Cytoplasm"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022705"}],"id":"KW-0235","category":"Biological process","name":"DNA replication"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00546"}],"id":"KW-0479","category":"Ligand","name":"Metal-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023016"}],"id":"KW-0346","category":"Biological process","name":"Stress response"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00546"}],"id":"KW-0862","category":"Ligand","name":"Zinc"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00546"}],"id":"KW-0863","category":"Domain","name":"Zinc-finger"}],"references":[{"referenceNumber":1,"citation":{"id":"17207598","citationType":"journal article","authors":["Nhung P.H.","Shah M.M.","Ohkusu K.","Noda M.","Hata H.","Sun X.S.","Iihara H.","Goto K.","Masaki T.","Miyasaka J.","Ezaki T."],"citationCrossReferences":[{"database":"PubMed","id":"17207598"},{"database":"DOI","id":"10.1016/j.syapm.2006.11.004"}],"title":"The dnaJ gene as a novel phylogenetic marker for identification of Vibrio species.","publicationDate":"2007","journal":"Syst. Appl. Microbiol.","firstPage":"309","lastPage":"315","volume":"30"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"BAF62496.1"}],"value":"GTC 335","type":"STRAIN"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"BAF62496.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AB263042","properties":[{"key":"ProteinId","value":"BAF62496.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"AlphaFoldDB","id":"A5A6V2","properties":[{"key":"Description","value":"-"}]},{"database":"GO","id":"GO:0005737","properties":[{"key":"GoTerm","value":"C:cytoplasm"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:0031072","properties":[{"key":"GoTerm","value":"F:heat shock protein binding"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0042026","properties":[{"key":"GoTerm","value":"P:protein refolding"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"CDD","id":"cd06257","properties":[{"key":"EntryName","value":"DnaJ"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.10.287.110","properties":[{"key":"EntryName","value":"DnaJ domain"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.10.230.10","properties":[{"key":"EntryName","value":"Heat shock protein DnaJ, cysteine-rich domain"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.60.260.20","properties":[{"key":"EntryName","value":"Urease metallochaperone UreE, N-terminal domain"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR001623","properties":[{"key":"EntryName","value":"DnaJ_domain"}]},{"database":"InterPro","id":"IPR018253","properties":[{"key":"EntryName","value":"DnaJ_domain_CS"}]},{"database":"InterPro","id":"IPR001305","properties":[{"key":"EntryName","value":"HSP_DnaJ_Cys-rich_dom"}]},{"database":"InterPro","id":"IPR036410","properties":[{"key":"EntryName","value":"HSP_DnaJ_Cys-rich_dom_sf"}]},{"database":"InterPro","id":"IPR036869","properties":[{"key":"EntryName","value":"J_dom_sf"}]},{"database":"PANTHER","id":"PTHR43096:SF48","properties":[{"key":"EntryName","value":"CHAPERONE PROTEIN DNAJ"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR43096","properties":[{"key":"EntryName","value":"DNAJ HOMOLOG 1, MITOCHONDRIAL-RELATED"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00226","properties":[{"key":"EntryName","value":"DnaJ"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR00625","properties":[{"key":"EntryName","value":"JDOMAIN"}]},{"database":"SMART","id":"SM00271","properties":[{"key":"EntryName","value":"DnaJ"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF46565","properties":[{"key":"EntryName","value":"Chaperone J-domain"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF57938","properties":[{"key":"EntryName","value":"DnaJ/Hsp40 cysteine-rich domain"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00636","properties":[{"key":"EntryName","value":"DNAJ_1"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50076","properties":[{"key":"EntryName","value":"DNAJ_2"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS51188","properties":[{"key":"EntryName","value":"ZF_CR"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"SRDASERDIKKAYKRLAMKYHPDKNPGDETAAEKFKEVKLAYEILTDDQKRAAYDQYGHAAFEHGGMGGGGGFGGGADFSDIFGDVFGDIFGGGRRGGQARAQRGADLRYNMELTLEEAVRGVTKEIDVPTYVGCDKCGGSGSKPGSSPQTCGTCHGQGQVQMRQGFFAV","length":170,"molWeight":18200,"crc64":"01D7A68DE09F75B4","md5":"78816E5217F9E0DFF1190CD1C64FCAE1"},"extraAttributes":{"countByFeatureType":{"Domain":2,"Zinc finger":1,"Non-terminal residue":2},"uniParcId":"UPI00015238F1"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"Q4H458","uniProtkbId":"Q4H458_GRIHO","entryAudit":{"firstPublicDate":"2005-08-30","lastAnnotationUpdateDate":"2026-01-28","lastSequenceUpdateDate":"2005-08-30","entryVersion":75,"sequenceVersion":1},"annotationScore":1.0,"organism":{"scientificName":"Grimontia hollisae","commonName":"Vibrio hollisae","taxonId":673,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"BAE16006.1"}],"lineage":["Bacteria","Pseudomonadati","Pseudomonadota","Gammaproteobacteria","Vibrionales","Vibrionaceae","Grimontia"]},"proteinExistence":"3: Inferred from homology","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"BAE16006.1"}],"value":"Ferric aerobactin receptor"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"BAE16006.1"}],"value":"iutA"}}],"comments":[{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004571"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU01360"}],"value":"Cell outer membrane","id":"SL-0040"},"topology":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004571"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU01360"}],"value":"Multi-pass membrane protein","id":"SL-9909"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00009810"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU01360"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003357"}],"value":"Belongs to the TonB-dependent receptor family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Signal","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":29,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}]},{"type":"Chain","location":{"start":{"value":30,"modifier":"EXACT"},"end":{"value":744,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"featureId":"PRO_5004239174"},{"type":"Domain","location":{"start":{"value":53,"modifier":"EXACT"},"end":{"value":155,"modifier":"EXACT"}},"description":"TonB-dependent receptor plug","evidences":[{"evidenceCode":"ECO:0000259","source":"Pfam","id":"PF07715"}]},{"type":"Domain","location":{"start":{"value":252,"modifier":"EXACT"},"end":{"value":701,"modifier":"EXACT"}},"description":"TonB-dependent receptor-like beta-barrel","evidences":[{"evidenceCode":"ECO:0000259","source":"Pfam","id":"PF00593"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023237"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU01360"}],"id":"KW-0998","category":"Cellular component","name":"Cell outer membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023065"}],"id":"KW-0406","category":"Biological process","name":"Ion transport"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023004"}],"id":"KW-0408","category":"Ligand","name":"Iron"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022496"}],"id":"KW-0410","category":"Biological process","name":"Iron transport"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023136"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU01360"}],"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023170"},{"evidenceCode":"ECO:0000313","source":"EMBL","id":"BAE16006.1"}],"id":"KW-0675","category":"Molecular function","name":"Receptor"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022729"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"id":"KW-0732","category":"Domain","name":"Signal"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023077"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003357"}],"id":"KW-0798","category":"Domain","name":"TonB box"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022692"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU01360"}],"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022452"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU01360"}],"id":"KW-1134","category":"Domain","name":"Transmembrane beta strand"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022448"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU01360"}],"id":"KW-0813","category":"Biological process","name":"Transport"}],"references":[{"referenceNumber":1,"citation":{"id":"16809025","citationType":"journal article","authors":["Suzuki K.","Tanabe T.","Moon Y.-H.","Funahashi T.","Nakao H.","Narimatsu S.","Yamamoto S."],"citationCrossReferences":[{"database":"PubMed","id":"16809025"},{"database":"DOI","id":"10.1016/j.resmic.2006.05.001"}],"title":"Identification and transcriptional organization of aerobactin transport and biosynthesis cluster genes of Vibrio hollisae.","publicationDate":"2006","journal":"Res. Microbiol.","firstPage":"730","lastPage":"740","volume":"157"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"BAE16006.1"}],"value":"ATCC 33564","type":"STRAIN"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"BAE16006.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AB199785","properties":[{"key":"ProteinId","value":"BAE16006.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"AlphaFoldDB","id":"Q4H458","properties":[{"key":"Description","value":"-"}]},{"database":"GO","id":"GO:0009279","properties":[{"key":"GoTerm","value":"C:cell outer membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0015344","properties":[{"key":"GoTerm","value":"F:siderophore uptake transmembrane transporter activity"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:0038023","properties":[{"key":"GoTerm","value":"F:signaling receptor activity"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0044718","properties":[{"key":"GoTerm","value":"P:siderophore transmembrane transport"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"CDD","id":"cd01347","properties":[{"key":"EntryName","value":"ligand_gated_channel"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.40.170.20:FF:000007","properties":[{"key":"EntryName","value":"Ferric aerobactin receptor"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.40.170.20","properties":[{"key":"EntryName","value":"TonB-dependent receptor, beta-barrel domain"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.170.130.10","properties":[{"key":"EntryName","value":"TonB-dependent receptor, plug domain"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR000531","properties":[{"key":"EntryName","value":"Beta-barrel_TonB"}]},{"database":"InterPro","id":"IPR036942","properties":[{"key":"EntryName","value":"Beta-barrel_TonB_sf"}]},{"database":"InterPro","id":"IPR012910","properties":[{"key":"EntryName","value":"Plug_dom"}]},{"database":"InterPro","id":"IPR037066","properties":[{"key":"EntryName","value":"Plug_dom_sf"}]},{"database":"InterPro","id":"IPR039426","properties":[{"key":"EntryName","value":"TonB-dep_rcpt-like"}]},{"database":"InterPro","id":"IPR010105","properties":[{"key":"EntryName","value":"TonB_sidphr_rcpt"}]},{"database":"NCBIfam","id":"TIGR01783","properties":[{"key":"EntryName","value":"TonB-siderophor"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR30069:SF42","properties":[{"key":"EntryName","value":"FERRIC AEROBACTIN RECEPTOR"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR30069","properties":[{"key":"EntryName","value":"TONB-DEPENDENT OUTER MEMBRANE RECEPTOR"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF07715","properties":[{"key":"EntryName","value":"Plug"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00593","properties":[{"key":"EntryName","value":"TonB_dep_Rec_b-barrel"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF56935","properties":[{"key":"EntryName","value":"Porins"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS52016","properties":[{"key":"EntryName","value":"TONB_DEPENDENT_REC_3"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MKLSRTFITNPFTLAICAAITTQSPVVSASTDTEGRAPLDTVVITGRSEKVISDIAGTVWVVDSEQIEQQYRGGKNLSEILASAVPALDVSSQGRTNFGQNMRGRPMLVMIDGVSLNSSRSVSRQLDAIDPFNIASIEVLSGASSIYGAGATGGIINIVTFRADASELAFESYAGATSGFNGGEDFDYKIAQSVSGGNDKVKGRVSVVYGENKGAFDADGNINVPDITQGSLQFNEVVDVLGTLNITPDSAQSIQLLAQYYSSKQDSPYGIYFGENLAGAPNNITGNPADTSLIETRKGFSSDRQGGTERLMLNANYHHNNVLGQDLFLQASFRREEFSFIPFIYGSYLAASEQNTDVLTLRAAMVKSMDNLTLTYGIDSYLDKLTSNQALFDRNLSYQSGGLINRTEAKIGRYPGTEVASVAGFVQADYQLTDDWSLSGGYRYQWMQNTIDDFVAASVQQQIAQGNGTSADAVPGGSTDYTIGLFNLGTVYKLSKNAQIWANFSQGFDLADPAKYYGQGNYSAPDANGHHTLTDSINVSSSKMQGIKTNSVEIGARQYLDALSWQAAAYISESDKTLKYNRQTLNIDVNDAKKRIYGIEAEVAYWLTDNLQTGLTGHWVDSEEQDSEGKWSKMSVNYASASKAGAWLGWYEDNYSVRLQNQTLFDLSDENNGKIDGYSLFDLIGTVELPKGRLGFGIQNLLNEDYTTVWGQRAKGWYSYYGPEEMFDYRGRGRTYTLNYSLSY","length":744,"molWeight":81304,"crc64":"271CF3EC2A42C281","md5":"8E51A644FAB5D2DA3D6935432498E5ED"},"extraAttributes":{"countByCommentType":{"SUBCELLULAR LOCATION":1,"SIMILARITY":1},"countByFeatureType":{"Signal":1,"Chain":1,"Domain":2},"uniParcId":"UPI0000562831"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"Q4H459","uniProtkbId":"Q4H459_GRIHO","entryAudit":{"firstPublicDate":"2005-08-30","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2005-08-30","entryVersion":42,"sequenceVersion":1},"annotationScore":1.0,"organism":{"scientificName":"Grimontia hollisae","commonName":"Vibrio hollisae","taxonId":673,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"BAE16005.1"}],"lineage":["Bacteria","Pseudomonadati","Pseudomonadota","Gammaproteobacteria","Vibrionales","Vibrionaceae","Grimontia"]},"proteinExistence":"3: Inferred from homology","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"BAE16005.1"}],"value":"Lysine N6-monooxygenase"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"BAE16005.1"}],"value":"iucD"}}],"comments":[{"commentType":"COFACTOR","cofactors":[{"name":"FAD","evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00001974"}],"cofactorCrossReference":{"database":"ChEBI","id":"CHEBI:57692"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004924"}],"value":"Siderophore biosynthesis"}],"commentType":"PATHWAY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00007588"}],"value":"Belongs to the lysine N(6)-hydroxylase/L-ornithine N(5)-oxygenase family"}],"commentType":"SIMILARITY"}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022827"}],"id":"KW-0274","category":"Ligand","name":"FAD"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022630"}],"id":"KW-0285","category":"Ligand","name":"Flavoprotein"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"BAE16005.1"}],"id":"KW-0503","category":"Molecular function","name":"Monooxygenase"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022857"}],"id":"KW-0521","category":"Ligand","name":"NADP"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023002"}],"id":"KW-0560","category":"Molecular function","name":"Oxidoreductase"}],"references":[{"referenceNumber":1,"citation":{"id":"16809025","citationType":"journal article","authors":["Suzuki K.","Tanabe T.","Moon Y.-H.","Funahashi T.","Nakao H.","Narimatsu S.","Yamamoto S."],"citationCrossReferences":[{"database":"PubMed","id":"16809025"},{"database":"DOI","id":"10.1016/j.resmic.2006.05.001"}],"title":"Identification and transcriptional organization of aerobactin transport and biosynthesis cluster genes of Vibrio hollisae.","publicationDate":"2006","journal":"Res. Microbiol.","firstPage":"730","lastPage":"740","volume":"157"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"BAE16005.1"}],"value":"ATCC 33564","type":"STRAIN"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"BAE16005.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AB199785","properties":[{"key":"ProteinId","value":"BAE16005.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"AlphaFoldDB","id":"Q4H459","properties":[{"key":"Description","value":"-"}]},{"database":"Gene3D","id":"3.50.50.60","properties":[{"key":"EntryName","value":"FAD/NAD(P)-binding domain"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR036188","properties":[{"key":"EntryName","value":"FAD/NAD-bd_sf"}]},{"database":"InterPro","id":"IPR025700","properties":[{"key":"EntryName","value":"Lys/Orn_oxygenase"}]},{"database":"PANTHER","id":"PTHR42802:SF1","properties":[{"key":"EntryName","value":"L-ORNITHINE N(5)-MONOOXYGENASE"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR42802","properties":[{"key":"EntryName","value":"MONOOXYGENASE"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF13434","properties":[{"key":"EntryName","value":"Lys_Orn_oxgnase"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF51905","properties":[{"key":"EntryName","value":"FAD/NAD(P)-binding domain"},{"key":"MatchStatus","value":"2"}]}],"sequence":{"value":"MTTTISSQVLDLAGIGAGPFNLSVAALLQQVPETKYCFFESRDSVSWHPGMLLDDTHMQTTFLKDLVTPVFPQSPYSFLAYLVEKKRIYRFLTAELGCISRTEFSDYLYWASEKLPNIAFSTCVEKIEFADGVFHIHTDKGTTLARNLCLGTGKSPHVPECMKPYIGEHIFHAAEIALSPRDFTGKRVAIIGGGQSGADVFINALRGTWGKFAKLDWVSRRPNYQPLDEAAFTNEYFTPDYVEAFLTLSPDVKAREVSMQKLTSDGVTQKALLEIYRELYQRFDVNNEEKWVRLLPHRTVTQLLSHKGGYELFLENGLANQLERLDADIIILATGYESRTPRCLDGLRPLINADSEGRFQLNQYFEVEWAHSDTNRIFAVNVGMHSHGIAEPQLSLMAWRSAQIINRLCQKPVFNTEAGPALIEWISPTSLVEAFA","length":436,"molWeight":49162,"crc64":"23ED67980E009546","md5":"2B1E4AC593260672E6DFC858043852CD"},"extraAttributes":{"countByCommentType":{"COFACTOR":1,"PATHWAY":1,"SIMILARITY":1},"uniParcId":"UPI0000562830"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"Q4H460","uniProtkbId":"Q4H460_GRIHO","entryAudit":{"firstPublicDate":"2005-08-30","lastAnnotationUpdateDate":"2025-04-02","lastSequenceUpdateDate":"2005-08-30","entryVersion":41,"sequenceVersion":1},"annotationScore":1.0,"organism":{"scientificName":"Grimontia hollisae","commonName":"Vibrio hollisae","taxonId":673,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"BAE16004.1"}],"lineage":["Bacteria","Pseudomonadati","Pseudomonadota","Gammaproteobacteria","Vibrionales","Vibrionaceae","Grimontia"]},"proteinExistence":"4: Predicted","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"BAE16004.1"}],"value":"Aerobactin synthetase"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"BAE16004.1"}],"value":"iucC"}}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004924"}],"value":"Siderophore biosynthesis"}],"commentType":"PATHWAY"}],"features":[{"type":"Domain","location":{"start":{"value":138,"modifier":"EXACT"},"end":{"value":382,"modifier":"EXACT"}},"description":"Aerobactin siderophore biosynthesis IucA/IucC N-terminal","evidences":[{"evidenceCode":"ECO:0000259","source":"Pfam","id":"PF04183"}]},{"type":"Domain","location":{"start":{"value":405,"modifier":"EXACT"},"end":{"value":563,"modifier":"EXACT"}},"description":"Aerobactin siderophore biosynthesis IucA/IucC-like C-terminal","evidences":[{"evidenceCode":"ECO:0000259","source":"Pfam","id":"PF06276"}]}],"references":[{"referenceNumber":1,"citation":{"id":"16809025","citationType":"journal article","authors":["Suzuki K.","Tanabe T.","Moon Y.-H.","Funahashi T.","Nakao H.","Narimatsu S.","Yamamoto S."],"citationCrossReferences":[{"database":"PubMed","id":"16809025"},{"database":"DOI","id":"10.1016/j.resmic.2006.05.001"}],"title":"Identification and transcriptional organization of aerobactin transport and biosynthesis cluster genes of Vibrio hollisae.","publicationDate":"2006","journal":"Res. Microbiol.","firstPage":"730","lastPage":"740","volume":"157"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"BAE16004.1"}],"value":"ATCC 33564","type":"STRAIN"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"BAE16004.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AB199785","properties":[{"key":"ProteinId","value":"BAE16004.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"AlphaFoldDB","id":"Q4H460","properties":[{"key":"Description","value":"-"}]},{"database":"GO","id":"GO:0016881","properties":[{"key":"GoTerm","value":"F:acid-amino acid ligase activity"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0019290","properties":[{"key":"GoTerm","value":"P:siderophore biosynthetic process"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"Gene3D","id":"1.10.510.40","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.30.310.280","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"6.10.250.3370","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR007310","properties":[{"key":"EntryName","value":"Aerobactin_biosyn_IucA/IucC_N"}]},{"database":"InterPro","id":"IPR022770","properties":[{"key":"EntryName","value":"IucA/IucC-like_C"}]},{"database":"InterPro","id":"IPR037455","properties":[{"key":"EntryName","value":"LucA/IucC-like"}]},{"database":"PANTHER","id":"PTHR34384","properties":[{"key":"EntryName","value":"L-2,3-DIAMINOPROPANOATE--CITRATE LIGASE"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR34384:SF6","properties":[{"key":"EntryName","value":"STAPHYLOFERRIN B SYNTHASE"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF06276","properties":[{"key":"EntryName","value":"FhuF"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF04183","properties":[{"key":"EntryName","value":"IucA_IucC"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MEQNALHRFWPAANRALVAKLISELEYEQAFKLEPVGQEHCLTLPAGVRYRVKGKRNIWGQLNILPGSIRREDNGEHNLPVEASRFMLDCKTVLGLDDDTLAEHLEDLYATLLGDCKLMQLREHLDADAFARLSLEKQQCLFDGHPKFVFNKGRRAWGSEDLRHFAPESEEPFQLCWIAVNHTLVTGAISEYLNWNHLYQNALSDDDLASVRCDLEMLGLNPANFLLLPVHPWQWDNKLSLLFVAELARKEMVYLGTFGDAFLPQLSLRTLTNVSRPARYDIKLPLTIMNTSCYRGMPSRYIQAGPQASAWLENTVKSDPLFISLGTDVLQEPAGLTVSHTVYDSLEKAPYRYHELCGAIWRESASTKTRPGEQAILMAALMESDSAGNPLIGAYIRASGLSAKDWLSQLFRAVVIPYYHLLAKYGVSLIAHGQNVTLVLENSTPKRILLKDFQGDMRLMQGDIPEQDSLPQAVKDVTVTLPPDLIIHDLQTGHFVTVLRFISPLAEKTGVSEHRFYKLLAQELQAYMQSHPELEARIQLLDLFRPKIRRLGLNLAKFRHATENSADRMLPQMEHFIDNPLYLVTH","length":586,"molWeight":66471,"crc64":"C32816F5A69CBBBC","md5":"7340DCBA9D98A650721C46672E3B0427"},"extraAttributes":{"countByCommentType":{"PATHWAY":1},"countByFeatureType":{"Domain":2},"uniParcId":"UPI000056282F"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"Q4H461","uniProtkbId":"Q4H461_GRIHO","entryAudit":{"firstPublicDate":"2005-08-30","lastAnnotationUpdateDate":"2026-11-04","lastSequenceUpdateDate":"2005-08-30","entryVersion":61,"sequenceVersion":1},"annotationScore":1.0,"organism":{"scientificName":"Grimontia hollisae","commonName":"Vibrio hollisae","taxonId":673,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"BAE16003.1"}],"lineage":["Bacteria","Pseudomonadati","Pseudomonadota","Gammaproteobacteria","Vibrionales","Vibrionaceae","Grimontia"]},"proteinExistence":"4: Predicted","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"BAE16003.1"}],"value":"N6-hydroxylysine acetyltransferase"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"BAE16003.1"}],"value":"iucB"}}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004924"}],"value":"Siderophore biosynthesis"}],"commentType":"PATHWAY"}],"features":[{"type":"Domain","location":{"start":{"value":141,"modifier":"EXACT"},"end":{"value":306,"modifier":"EXACT"}},"description":"N-acetyltransferase","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS51186"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00532"}],"id":"KW-0012","category":"Molecular function","name":"Acyltransferase"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023251"}],"id":"KW-0046","category":"Biological process","name":"Antibiotic resistance"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00532"},{"evidenceCode":"ECO:0000313","source":"EMBL","id":"BAE16003.1"}],"id":"KW-0808","category":"Molecular function","name":"Transferase"}],"references":[{"referenceNumber":1,"citation":{"id":"16809025","citationType":"journal article","authors":["Suzuki K.","Tanabe T.","Moon Y.-H.","Funahashi T.","Nakao H.","Narimatsu S.","Yamamoto S."],"citationCrossReferences":[{"database":"PubMed","id":"16809025"},{"database":"DOI","id":"10.1016/j.resmic.2006.05.001"}],"title":"Identification and transcriptional organization of aerobactin transport and biosynthesis cluster genes of Vibrio hollisae.","publicationDate":"2006","journal":"Res. Microbiol.","firstPage":"730","lastPage":"740","volume":"157"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"BAE16003.1"}],"value":"ATCC 33564","type":"STRAIN"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"BAE16003.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AB199785","properties":[{"key":"ProteinId","value":"BAE16003.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"AlphaFoldDB","id":"Q4H461","properties":[{"key":"Description","value":"-"}]},{"database":"GO","id":"GO:0016407","properties":[{"key":"GoTerm","value":"F:acetyltransferase activity"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniRule"}]},{"database":"GO","id":"GO:0019290","properties":[{"key":"GoTerm","value":"P:siderophore biosynthetic process"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"Gene3D","id":"3.40.630.30","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR016181","properties":[{"key":"EntryName","value":"Acyl_CoA_acyltransferase"}]},{"database":"InterPro","id":"IPR019432","properties":[{"key":"EntryName","value":"Acyltransferase_MbtK/IucB-like"}]},{"database":"InterPro","id":"IPR000182","properties":[{"key":"EntryName","value":"GNAT_dom"}]},{"database":"PANTHER","id":"PTHR31438","properties":[{"key":"EntryName","value":"LYSINE N-ACYLTRANSFERASE C17G9.06C-RELATED"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR31438:SF1","properties":[{"key":"EntryName","value":"LYSINE N-ACYLTRANSFERASE C17G9.06C-RELATED"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF13523","properties":[{"key":"EntryName","value":"Acetyltransf_8"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM01006","properties":[{"key":"EntryName","value":"AlcB"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF55729","properties":[{"key":"EntryName","value":"Acyl-CoA N-acyltransferases (Nat)"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS51186","properties":[{"key":"EntryName","value":"GNAT"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MSDCQLSLSPTTDKHHLDDIFPLLEPEMLIAAGEKNSGDSLASALDHYFCVNPKSPAVQLPRERWNSHIAPSHWLYMFLDDVLTRSQFNQLPATGLCHMPTDRYPALPVQSTKQSGFHPKRPASPKGYVYQRTDPLNGITVSYRLFEPEKDMPRFTRWMNCPRVADFWEQAWSEEALLDYINGRLSDPHTLPLIGEFDGQPFGYIEAYWVSEDRLAPYYDSQPFDRGIHVLVGEEAFRGERYFNMWMRAITHYLFLDDCRTMRVVLEPRYDNTRLFNRIKSVGYKQKFLFDFPHKRAALMMTSRYAFFREQW","length":312,"molWeight":36643,"crc64":"3B20F4243208C047","md5":"5972103B399151ED35D9A4FC8E919A68"},"extraAttributes":{"countByCommentType":{"PATHWAY":1},"countByFeatureType":{"Domain":1},"uniParcId":"UPI000056282E"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"Q4H462","uniProtkbId":"Q4H462_GRIHO","entryAudit":{"firstPublicDate":"2005-08-30","lastAnnotationUpdateDate":"2025-04-02","lastSequenceUpdateDate":"2005-08-30","entryVersion":41,"sequenceVersion":1},"annotationScore":1.0,"organism":{"scientificName":"Grimontia hollisae","commonName":"Vibrio hollisae","taxonId":673,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"BAE16002.1"}],"lineage":["Bacteria","Pseudomonadati","Pseudomonadota","Gammaproteobacteria","Vibrionales","Vibrionaceae","Grimontia"]},"proteinExistence":"3: Inferred from homology","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"BAE16002.1"}],"value":"Aerobactin synthetase"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"BAE16002.1"}],"value":"iucA"}}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00007832"}],"value":"Belongs to the IucA/IucC family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Domain","location":{"start":{"value":141,"modifier":"EXACT"},"end":{"value":387,"modifier":"EXACT"}},"description":"Aerobactin siderophore biosynthesis IucA/IucC N-terminal","evidences":[{"evidenceCode":"ECO:0000259","source":"Pfam","id":"PF04183"}]},{"type":"Domain","location":{"start":{"value":419,"modifier":"EXACT"},"end":{"value":576,"modifier":"EXACT"}},"description":"Aerobactin siderophore biosynthesis IucA/IucC-like C-terminal","evidences":[{"evidenceCode":"ECO:0000259","source":"Pfam","id":"PF06276"}]}],"references":[{"referenceNumber":1,"citation":{"id":"16809025","citationType":"journal article","authors":["Suzuki K.","Tanabe T.","Moon Y.-H.","Funahashi T.","Nakao H.","Narimatsu S.","Yamamoto S."],"citationCrossReferences":[{"database":"PubMed","id":"16809025"},{"database":"DOI","id":"10.1016/j.resmic.2006.05.001"}],"title":"Identification and transcriptional organization of aerobactin transport and biosynthesis cluster genes of Vibrio hollisae.","publicationDate":"2006","journal":"Res. Microbiol.","firstPage":"730","lastPage":"740","volume":"157"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"BAE16002.1"}],"value":"ATCC 33564","type":"STRAIN"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"BAE16002.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AB199785","properties":[{"key":"ProteinId","value":"BAE16002.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"AlphaFoldDB","id":"Q4H462","properties":[{"key":"Description","value":"-"}]},{"database":"GO","id":"GO:0016881","properties":[{"key":"GoTerm","value":"F:acid-amino acid ligase activity"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0019290","properties":[{"key":"GoTerm","value":"P:siderophore biosynthetic process"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"Gene3D","id":"1.10.510.40","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"6.10.250.3370","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR007310","properties":[{"key":"EntryName","value":"Aerobactin_biosyn_IucA/IucC_N"}]},{"database":"InterPro","id":"IPR022770","properties":[{"key":"EntryName","value":"IucA/IucC-like_C"}]},{"database":"InterPro","id":"IPR037455","properties":[{"key":"EntryName","value":"LucA/IucC-like"}]},{"database":"PANTHER","id":"PTHR34384","properties":[{"key":"EntryName","value":"L-2,3-DIAMINOPROPANOATE--CITRATE LIGASE"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR34384:SF5","properties":[{"key":"EntryName","value":"L-2,3-DIAMINOPROPANOATE--CITRATE LIGASE"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF06276","properties":[{"key":"EntryName","value":"FhuF"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF04183","properties":[{"key":"EntryName","value":"IucA_IucC"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MEDQQHCYGLKGSDVAIACFLNAFLRECPKVGAKKTGEDHYQLQIPVNDHYHIAYQISKYSTLGLHEYKMPAYLVTKDRATPLSFSDVLFKVVSEPALVGNLTEQQKNAFVARVLESQRNTHNAITHQPNLEALFSTTLRFEQAEQGLLAGHSVHPAPKSREQFSQHDAKRYSPEFGGKFPLRWFAVAKWLTLSHYTGEDLGKEARESNGQNAPHHPVNALADADMALSEAARAIPDGFALFPAHPWQAEVLLKHPDIKNYQSRGLLLDLGEMGQYWYPLLPPVPFTAPVCFPAEILLECKLTNSIRTLSLKEVMRGTRLNQIFQSAGFAQVDAALPDGFEVMQEPGFLALLDTHGNVIDESLVALRDNLLAKTPDEEAVVLATLCQQHPFGRDSLLAARVKQLAAHLATTPENAAIKWFDNYCHQVVGSLFSLQGNGGIVCLAHQQNIVMRLQDGMPVGMYYRDCQGTGYTDLAYTLFPDILIDDTQDLENHWEQEKVLRYFPYYLIINSTFSVIASLSLHCGVSEGALLERLRAYLKSLKGKLVDTHCLNYVLESPALCCKGNFYCYLQDLNENAIPDPKVIYFDLPNPLVCHATDNRPSSEKEAHYV","length":610,"molWeight":68263,"crc64":"4766BE83D7ED2E37","md5":"A8178FF60A86815CF0F8588EF9FA9F64"},"extraAttributes":{"countByCommentType":{"SIMILARITY":1},"countByFeatureType":{"Domain":2},"uniParcId":"UPI000056282D"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"Q4H463","uniProtkbId":"Q4H463_GRIHO","entryAudit":{"firstPublicDate":"2005-08-30","lastAnnotationUpdateDate":"2026-11-04","lastSequenceUpdateDate":"2005-08-30","entryVersion":73,"sequenceVersion":1},"annotationScore":1.0,"organism":{"scientificName":"Grimontia hollisae","commonName":"Vibrio hollisae","taxonId":673,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"BAE16001.1"}],"lineage":["Bacteria","Pseudomonadati","Pseudomonadota","Gammaproteobacteria","Vibrionales","Vibrionaceae","Grimontia"]},"proteinExistence":"3: Inferred from homology","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"BAE16001.1"}],"value":"Membrane permease"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"BAE16001.1"}],"value":"hatB"}}],"comments":[{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004651"}],"value":"Cell membrane","id":"SL-0039"},"topology":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004651"}],"value":"Multi-pass membrane protein","id":"SL-9909"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00096319"}],"value":"Belongs to the binding protein-dependent transport system permease family. FecCD subfamily"}],"commentType":"SIMILARITY"}],"features":[{"type":"Transmembrane","location":{"start":{"value":12,"modifier":"EXACT"},"end":{"value":32,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":69,"modifier":"EXACT"},"end":{"value":90,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":96,"modifier":"EXACT"},"end":{"value":117,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":124,"modifier":"EXACT"},"end":{"value":143,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":155,"modifier":"EXACT"},"end":{"value":175,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":202,"modifier":"EXACT"},"end":{"value":223,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":243,"modifier":"EXACT"},"end":{"value":273,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":285,"modifier":"EXACT"},"end":{"value":303,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":309,"modifier":"EXACT"},"end":{"value":332,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":359,"modifier":"EXACT"},"end":{"value":378,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":398,"modifier":"EXACT"},"end":{"value":418,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":430,"modifier":"EXACT"},"end":{"value":451,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":457,"modifier":"EXACT"},"end":{"value":474,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":486,"modifier":"EXACT"},"end":{"value":507,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":527,"modifier":"EXACT"},"end":{"value":547,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":574,"modifier":"EXACT"},"end":{"value":596,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":616,"modifier":"EXACT"},"end":{"value":634,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":641,"modifier":"EXACT"},"end":{"value":661,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022475"}],"id":"KW-1003","category":"Cellular component","name":"Cell membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023136"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022692"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022989"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-1133","category":"Domain","name":"Transmembrane helix"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022448"}],"id":"KW-0813","category":"Biological process","name":"Transport"}],"references":[{"referenceNumber":1,"citation":{"id":"16809025","citationType":"journal article","authors":["Suzuki K.","Tanabe T.","Moon Y.-H.","Funahashi T.","Nakao H.","Narimatsu S.","Yamamoto S."],"citationCrossReferences":[{"database":"PubMed","id":"16809025"},{"database":"DOI","id":"10.1016/j.resmic.2006.05.001"}],"title":"Identification and transcriptional organization of aerobactin transport and biosynthesis cluster genes of Vibrio hollisae.","publicationDate":"2006","journal":"Res. Microbiol.","firstPage":"730","lastPage":"740","volume":"157"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"BAE16001.1"}],"value":"ATCC 33564","type":"STRAIN"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"BAE16001.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AB199785","properties":[{"key":"ProteinId","value":"BAE16001.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"RefSeq","id":"WP_005505276.1","properties":[{"key":"NucleotideSequenceId","value":"NZ_CP014056.2"}]},{"database":"AlphaFoldDB","id":"Q4H463","properties":[{"key":"Description","value":"-"}]},{"database":"GeneID","id":"58897565","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"gho:AL542_16555","properties":[{"key":"Description","value":"-"}]},{"database":"GO","id":"GO:0005886","properties":[{"key":"GoTerm","value":"C:plasma membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0022857","properties":[{"key":"GoTerm","value":"F:transmembrane transporter activity"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0033214","properties":[{"key":"GoTerm","value":"P:siderophore-iron import into cell"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"CDD","id":"cd06550","properties":[{"key":"EntryName","value":"TM_ABC_iron-siderophores_like"},{"key":"MatchStatus","value":"2"}]},{"database":"Gene3D","id":"1.10.3470.10","properties":[{"key":"EntryName","value":"ABC transporter involved in vitamin B12 uptake, BtuC"},{"key":"MatchStatus","value":"2"}]},{"database":"InterPro","id":"IPR037294","properties":[{"key":"EntryName","value":"ABC_BtuC-like"}]},{"database":"InterPro","id":"IPR000522","properties":[{"key":"EntryName","value":"ABC_transptr_permease_BtuC"}]},{"database":"NCBIfam","id":"NF007866","properties":[{"key":"EntryName","value":"fhuB"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR30472:SF37","properties":[{"key":"EntryName","value":"FE(3+) DICITRATE TRANSPORT SYSTEM PERMEASE PROTEIN FECD-RELATED"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR30472","properties":[{"key":"EntryName","value":"FERRIC ENTEROBACTIN TRANSPORT SYSTEM PERMEASE PROTEIN"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF01032","properties":[{"key":"EntryName","value":"FecCD"},{"key":"MatchStatus","value":"2"}]},{"database":"SUPFAM","id":"SSF81345","properties":[{"key":"EntryName","value":"ABC transporter involved in vitamin B12 uptake, BtuC"},{"key":"MatchStatus","value":"2"}]}],"sequence":{"value":"MNTLPYPNPANHPYRVTGMVVTILSLILLLIYTSAPYPLTATDWLGAILSPDEEDYRQIIIHYSYLPRLAMAILCGAALAIAGCVMRFVLNNPLASPTTLGVAAGAELGLVTGTLFFSATAGLSLYLSAFTGGLLATLLVFAITPRQSYSPLSLILSGMVTTLFIGAVTMMLVLVNEQTLTHLFLWGAGALEQNDWQGVTRLLPFLIVPVLLLTGISRALSLLQLGDTVAGSLGAKVVRVRLAALTLSVVMTASVVSEVGIIGFVGLVSPAIARILGARRLPGQIALSACIGALLLLGADLLVQNLSHWVADVIPTGAVTALLGAPFMLYLLQRRLLGSALSSANTMHQPGKRLPFKPLALLLVLFFVFTVSVSMTWGQSDAGWVFGIDPALLSLRGFRIAVAALAGASLAMAGCVIQRLTGNPMASPEVLGISAGCALAIVLAAAFGLALSRLEQLLFGALGAVAVMALILWFSRKKTASPTHFILIGIAISAMADAIIRLTMASGQEGVKSLLSWLSGSLYLADTMAVGLLIITLILFGSFTVAFSRWLDVINLGDTVSESLGLSVKATRKVLIVIAAIMTSAATIAIGPLSFIGLLAPHMATSLGQHSARQQLMIAPILGAILLVMADWVGRNLWFPWQFPAGLLASIIGAAYFLNLLRR","length":663,"molWeight":69756,"crc64":"E866AE25C2C0ED18","md5":"F19BEA2DF35040A05893F7B89125576E"},"extraAttributes":{"countByCommentType":{"SUBCELLULAR LOCATION":1,"SIMILARITY":1},"countByFeatureType":{"Transmembrane":18},"uniParcId":"UPI000056282C"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"Q4H464","uniProtkbId":"Q4H464_GRIHO","entryAudit":{"firstPublicDate":"2005-08-30","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2005-08-30","entryVersion":55,"sequenceVersion":1},"annotationScore":1.0,"organism":{"scientificName":"Grimontia hollisae","commonName":"Vibrio hollisae","taxonId":673,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"BAE16000.1"}],"lineage":["Bacteria","Pseudomonadati","Pseudomonadota","Gammaproteobacteria","Vibrionales","Vibrionaceae","Grimontia"]},"proteinExistence":"3: Inferred from homology","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"BAE16000.1"}],"value":"Periplasmic binding protein"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"BAE16000.1"}],"value":"hatD"}}],"comments":[{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004196"}],"value":"Cell envelope","id":"SL-0036"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00008814"}],"value":"Belongs to the bacterial solute-binding protein 8 family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Signal","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":17,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}]},{"type":"Chain","location":{"start":{"value":18,"modifier":"EXACT"},"end":{"value":299,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"featureId":"PRO_5009970958"},{"type":"Domain","location":{"start":{"value":35,"modifier":"EXACT"},"end":{"value":297,"modifier":"EXACT"}},"description":"Fe/B12 periplasmic-binding","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50983"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022496"}],"id":"KW-0406","category":"Biological process","name":"Ion transport"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022496"}],"id":"KW-0408","category":"Ligand","name":"Iron"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022496"}],"id":"KW-0410","category":"Biological process","name":"Iron transport"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00344"}],"id":"KW-0574","category":"Cellular component","name":"Periplasm"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022729"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00344"}],"id":"KW-0732","category":"Domain","name":"Signal"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022448"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00344"}],"id":"KW-0813","category":"Biological process","name":"Transport"}],"references":[{"referenceNumber":1,"citation":{"id":"16809025","citationType":"journal article","authors":["Suzuki K.","Tanabe T.","Moon Y.-H.","Funahashi T.","Nakao H.","Narimatsu S.","Yamamoto S."],"citationCrossReferences":[{"database":"PubMed","id":"16809025"},{"database":"DOI","id":"10.1016/j.resmic.2006.05.001"}],"title":"Identification and transcriptional organization of aerobactin transport and biosynthesis cluster genes of Vibrio hollisae.","publicationDate":"2006","journal":"Res. Microbiol.","firstPage":"730","lastPage":"740","volume":"157"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"BAE16000.1"}],"value":"ATCC 33564","type":"STRAIN"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"BAE16000.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AB199785","properties":[{"key":"ProteinId","value":"BAE16000.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"RefSeq","id":"WP_005505277.1","properties":[{"key":"NucleotideSequenceId","value":"NZ_CP014056.2"}]},{"database":"AlphaFoldDB","id":"Q4H464","properties":[{"key":"Description","value":"-"}]},{"database":"GeneID","id":"58897566","properties":[{"key":"Description","value":"-"}]},{"database":"GO","id":"GO:0030288","properties":[{"key":"GoTerm","value":"C:outer membrane-bounded periplasmic space"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:1901678","properties":[{"key":"GoTerm","value":"P:iron coordination entity transport"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"CDD","id":"cd01146","properties":[{"key":"EntryName","value":"FhuD"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.40.50.1980","properties":[{"key":"EntryName","value":"Nitrogenase molybdenum iron protein domain"},{"key":"MatchStatus","value":"2"}]},{"database":"InterPro","id":"IPR002491","properties":[{"key":"EntryName","value":"ABC_transptr_periplasmic_BD"}]},{"database":"InterPro","id":"IPR051313","properties":[{"key":"EntryName","value":"Bact_iron-sidero_bind"}]},{"database":"PANTHER","id":"PTHR30532","properties":[{"key":"EntryName","value":"IRON III DICITRATE-BINDING PERIPLASMIC PROTEIN"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR30532:SF1","properties":[{"key":"EntryName","value":"IRON(3+)-HYDROXAMATE-BINDING PROTEIN FHUD"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF01497","properties":[{"key":"EntryName","value":"Peripla_BP_2"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR01715","properties":[{"key":"EntryName","value":"FERRIBNDNGPP"}]},{"database":"SUPFAM","id":"SSF53807","properties":[{"key":"EntryName","value":"Helical backbone' metal receptor"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50983","properties":[{"key":"EntryName","value":"FE_B12_PBP"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MRRVVCLSLFFFSHAFALTVKHDLGETEIPNIPQRVVALDWVSTETLLSLGITPFAIADTDGYRHWVAFPALPDTVKDVGSRREPNLESITALKPDLIVINEAHAAVYPALAKIAPTVAFNVFNGEKKPLKALRTMTVTVGSIFGKEDVSHDVINAAQHIFQQNNAKLHEAGMANLPLVVIRFIGNTHVRIHGEGSLANDIVVELGLRNSWQEKTNNWGFSSSGIEALAKHQQATVVYLESLDDAQRKAIFSTPLWKAMRFSRENNVIALPPIWTFGGLISAQRMSNEITANLIGNAEK","length":299,"molWeight":32969,"crc64":"2D6D0379CC28965A","md5":"C2FEBA8C1A1FC377D4C9814F316D4B20"},"extraAttributes":{"countByCommentType":{"SUBCELLULAR LOCATION":1,"SIMILARITY":1},"countByFeatureType":{"Signal":1,"Chain":1,"Domain":1},"uniParcId":"UPI000056282B"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"Q4H466","uniProtkbId":"Q4H466_GRIHO","entryAudit":{"firstPublicDate":"2005-08-30","lastAnnotationUpdateDate":"2026-11-04","lastSequenceUpdateDate":"2005-08-30","entryVersion":68,"sequenceVersion":1},"annotationScore":1.0,"organism":{"scientificName":"Grimontia hollisae","commonName":"Vibrio hollisae","taxonId":673,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"BAE15998.1"}],"lineage":["Bacteria","Pseudomonadati","Pseudomonadota","Gammaproteobacteria","Vibrionales","Vibrionaceae","Grimontia"]},"proteinExistence":"4: Predicted","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"STO57544.1"}],"value":"Major Facilitator Superfamily"}}]},"genes":[{"orfNames":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"STO57544.1"}],"value":"NCTC11645_01936"}]}],"comments":[{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004370"}],"value":"Membrane","id":"SL-0162"}}]}],"features":[{"type":"Transmembrane","location":{"start":{"value":20,"modifier":"EXACT"},"end":{"value":44,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":50,"modifier":"EXACT"},"end":{"value":71,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":83,"modifier":"EXACT"},"end":{"value":102,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":114,"modifier":"EXACT"},"end":{"value":134,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":154,"modifier":"EXACT"},"end":{"value":175,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":181,"modifier":"EXACT"},"end":{"value":201,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":222,"modifier":"EXACT"},"end":{"value":243,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":263,"modifier":"EXACT"},"end":{"value":282,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":294,"modifier":"EXACT"},"end":{"value":311,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":317,"modifier":"EXACT"},"end":{"value":335,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":347,"modifier":"EXACT"},"end":{"value":369,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":375,"modifier":"EXACT"},"end":{"value":398,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Domain","location":{"start":{"value":17,"modifier":"EXACT"},"end":{"value":402,"modifier":"EXACT"}},"description":"Major facilitator superfamily (MFS) profile","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50850"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023136"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022692"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022989"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-1133","category":"Domain","name":"Transmembrane helix"}],"references":[{"referenceNumber":1,"citation":{"id":"16809025","citationType":"journal article","authors":["Suzuki K.","Tanabe T.","Moon Y.-H.","Funahashi T.","Nakao H.","Narimatsu S.","Yamamoto S."],"citationCrossReferences":[{"database":"PubMed","id":"16809025"},{"database":"DOI","id":"10.1016/j.resmic.2006.05.001"}],"title":"Identification and transcriptional organization of aerobactin transport and biosynthesis cluster genes of Vibrio hollisae.","publicationDate":"2006","journal":"Res. Microbiol.","firstPage":"730","lastPage":"740","volume":"157"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"BAE15998.1"}],"value":"ATCC 33564","type":"STRAIN"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"BAE15998.1"}]},{"referenceNumber":2,"citation":{"id":"CI-AB4PR2KKK46L9","citationType":"submission","authoringGroup":["Pathogen Informatics"],"authors":["Doyle S."],"publicationDate":"JUN-2018","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"STO57544.1"}],"value":"NCTC11645","type":"STRAIN"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"STO57544.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AB199785","properties":[{"key":"ProteinId","value":"BAE15998.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"UGHD01000002","properties":[{"key":"ProteinId","value":"STO57544.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"RefSeq","id":"WP_040529012.1","properties":[{"key":"NucleotideSequenceId","value":"NZ_CP014056.2"}]},{"database":"AlphaFoldDB","id":"Q4H466","properties":[{"key":"Description","value":"-"}]},{"database":"STRING","id":"673.AL542_16570","properties":[{"key":"Description","value":"-"}]},{"database":"GeneID","id":"58897568","properties":[{"key":"Description","value":"-"}]},{"database":"GO","id":"GO:0016020","properties":[{"key":"GoTerm","value":"C:membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0022857","properties":[{"key":"GoTerm","value":"F:transmembrane transporter activity"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"Gene3D","id":"1.20.1250.20","properties":[{"key":"EntryName","value":"MFS general substrate transporter like domains"},{"key":"MatchStatus","value":"2"}]},{"database":"InterPro","id":"IPR011701","properties":[{"key":"EntryName","value":"MFS"}]},{"database":"InterPro","id":"IPR020846","properties":[{"key":"EntryName","value":"MFS_dom"}]},{"database":"InterPro","id":"IPR036259","properties":[{"key":"EntryName","value":"MFS_trans_sf"}]},{"database":"PANTHER","id":"PTHR23546:SF1","properties":[{"key":"EntryName","value":"MEMBRANE PROTEIN"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR23546","properties":[{"key":"EntryName","value":"TRANSPORT PROTEIN"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF07690","properties":[{"key":"EntryName","value":"MFS_1"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF103473","properties":[{"key":"EntryName","value":"MFS general substrate transporter"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50850","properties":[{"key":"EntryName","value":"MFS"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MRTPLSKNQERKGVKASATVIASIAALMGLGQGGLLVSLPVLVSETQLSLTVWSIVIATGSVFFLPASPYWGRQSDLNGPKPIVLQALVGFGMSFGLLYVFIRFTNTSNLPDAWVIAGLVTARIVYGLTVAGMVPAAQHWAVLLKGEEKRLEAITTISAGMSTGRLLGPLLAIALLNIHPLAPLITLTMLPFIGLLIVKSLPDPGRQTHTQTKPSAPVLPPWRAVPFLFIAMLGSAALALMQYTLTPMLQVATEWSVSDISNAVGMLLTVSAAITLTTQILVIKRQRLSARRMLVAGAVLMLSGYTLFLSLHWPVLVLAVGLVAAGGALFVPAYVSEATSRTVAQQGTMAGYIAMSHTLGYGLSALLVMSLAFGVVIPIGINITLSGIILFVSVVLYLKPRQ","length":402,"molWeight":42573,"crc64":"93EE0C34A87EB6E1","md5":"D77D1290D2584F4F7E38C764250BAB43"},"extraAttributes":{"countByCommentType":{"SUBCELLULAR LOCATION":1},"countByFeatureType":{"Transmembrane":12,"Domain":1},"uniParcId":"UPI0000562829"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"Q93QK2","uniProtkbId":"Q93QK2_GRIHO","entryAudit":{"firstPublicDate":"2001-12-01","lastAnnotationUpdateDate":"2026-11-04","lastSequenceUpdateDate":"2001-12-01","entryVersion":77,"sequenceVersion":1},"annotationScore":1.0,"organism":{"scientificName":"Grimontia hollisae","commonName":"Vibrio hollisae","taxonId":673,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAK69006.1"}],"lineage":["Bacteria","Pseudomonadati","Pseudomonadota","Gammaproteobacteria","Vibrionales","Vibrionaceae","Grimontia"]},"proteinExistence":"3: Inferred from homology","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAK69006.1"}],"value":"Hsp60"}}],"flag":"Fragment"},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAK69006.1"}],"value":"hsp60"}}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00006607"}],"value":"Belongs to the chaperonin (HSP60) family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Non-terminal residue","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":1,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAK69006.1"}]},{"type":"Non-terminal residue","location":{"start":{"value":184,"modifier":"EXACT"},"end":{"value":184,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAK69006.1"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022840"}],"id":"KW-0067","category":"Ligand","name":"ATP-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023186"}],"id":"KW-0143","category":"Molecular function","name":"Chaperone"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023235"}],"id":"KW-0413","category":"Molecular function","name":"Isomerase"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022741"}],"id":"KW-0547","category":"Ligand","name":"Nucleotide-binding"}],"references":[{"referenceNumber":1,"citation":{"id":"12489780","citationType":"journal article","authors":["Kwok A.Y.","Wilson J.T.","Coulthart M.","Ng L.K.","Mutharia L.","Chow A.W."],"citationCrossReferences":[{"database":"PubMed","id":"12489780"},{"database":"DOI","id":"10.1139/w02-089"}],"title":"Phylogenetic study and identification of human pathogenic Vibrio species based on partial hsp60 gene sequences.","publicationDate":"2002","journal":"Can. J. Microbiol.","firstPage":"903","lastPage":"910","volume":"48"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAK69006.1"}],"value":"ATCC33564","type":"STRAIN"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAK69006.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AF230943","properties":[{"key":"ProteinId","value":"AAK69006.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"AlphaFoldDB","id":"Q93QK2","properties":[{"key":"Description","value":"-"}]},{"database":"GO","id":"GO:0005524","properties":[{"key":"GoTerm","value":"F:ATP binding"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0140662","properties":[{"key":"GoTerm","value":"F:ATP-dependent protein folding chaperone"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0042026","properties":[{"key":"GoTerm","value":"P:protein refolding"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"FunFam","id":"3.50.7.10:FF:000001","properties":[{"key":"EntryName","value":"60 kDa chaperonin"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.50.7.10","properties":[{"key":"EntryName","value":"GroEL"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.10.560.10","properties":[{"key":"EntryName","value":"GroEL-like equatorial domain"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.30.260.10","properties":[{"key":"EntryName","value":"TCP-1-like chaperonin intermediate domain"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR001844","properties":[{"key":"EntryName","value":"Cpn60/GroEL"}]},{"database":"InterPro","id":"IPR002423","properties":[{"key":"EntryName","value":"Cpn60/GroEL/TCP-1"}]},{"database":"InterPro","id":"IPR027409","properties":[{"key":"EntryName","value":"GroEL-like_apical_dom_sf"}]},{"database":"InterPro","id":"IPR027413","properties":[{"key":"EntryName","value":"GROEL-like_equatorial_sf"}]},{"database":"InterPro","id":"IPR027410","properties":[{"key":"EntryName","value":"TCP-1-like_intermed_sf"}]},{"database":"PANTHER","id":"PTHR45633","properties":[{"key":"EntryName","value":"60 KDA HEAT SHOCK PROTEIN, MITOCHONDRIAL"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00118","properties":[{"key":"EntryName","value":"Cpn60_TCP1"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF52029","properties":[{"key":"EntryName","value":"GroEL apical domain-like"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF48592","properties":[{"key":"EntryName","value":"GroEL equatorial domain-like"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"ATVLAQAIVSEGLKAVAAGMNPMDLKRGIDKAVAAAVEQLKALSVECNDTKAIAQVGTISANSDETVGNIIAEAMEKVGRDGVITVEEGQSLQDELDVVEGMQFDRGYLSPYFINNQESGSVDLENPFILLVDKKVSNIRELLPTLEAVAKSSRPLLIIAEDVEGEALATLVVNNMRGIVKGQQ","length":184,"molWeight":19551,"crc64":"5367F51F8854821E","md5":"0F2EA6B8F771254285F0FB69E429FD63"},"extraAttributes":{"countByCommentType":{"SIMILARITY":1},"countByFeatureType":{"Non-terminal residue":2},"uniParcId":"UPI00000BE18F"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"Q9RFS1","uniProtkbId":"Q9RFS1_GRIHO","entryAudit":{"firstPublicDate":"2000-05-01","lastAnnotationUpdateDate":"2026-11-04","lastSequenceUpdateDate":"2000-05-01","entryVersion":84,"sequenceVersion":1},"annotationScore":1.0,"organism":{"scientificName":"Grimontia hollisae","commonName":"Vibrio hollisae","taxonId":673,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAD47875.1"}],"lineage":["Bacteria","Pseudomonadati","Pseudomonadota","Gammaproteobacteria","Vibrionales","Vibrionaceae","Grimontia"]},"proteinExistence":"4: Predicted","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAD47875.1"}],"value":"Transmembrane regulatory protein ToxR"}}],"flag":"Fragment"},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAD47875.1"}],"value":"toxR"}}],"features":[{"type":"Transmembrane","location":{"start":{"value":110,"modifier":"EXACT"},"end":{"value":130,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Domain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":44,"modifier":"EXACT"}},"description":"OmpR/PhoB-type","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS51755"}]},{"type":"DNA binding","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":44,"modifier":"EXACT"}},"description":"OmpR/PhoB-type","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU01091"}]},{"type":"Non-terminal residue","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":1,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAD47875.1"}]},{"type":"Non-terminal residue","location":{"start":{"value":193,"modifier":"EXACT"},"end":{"value":193,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAD47875.1"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023125"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU01091"}],"id":"KW-0238","category":"Molecular function","name":"DNA-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"},{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAD47875.1"}],"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-1133","category":"Domain","name":"Transmembrane helix"}],"references":[{"referenceNumber":1,"citation":{"id":"10629204","citationType":"journal article","authors":["Osorio C.R.","Klose K.E."],"citationCrossReferences":[{"database":"PubMed","id":"10629204"},{"database":"DOI","id":"10.1128/JB.182.2.526-528.2000"}],"title":"A region of the transmembrane regulatory protein ToxR that tethers the transcriptional activation domain to the cytoplasmic membrane displays wide divergence among Vibrio species.","publicationDate":"2000","journal":"J. Bacteriol.","firstPage":"526","lastPage":"528","volume":"182"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAD47875.1"}],"value":"ATCC 33564","type":"STRAIN"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAD47875.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AF170884","properties":[{"key":"ProteinId","value":"AAD47875.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"AlphaFoldDB","id":"Q9RFS1","properties":[{"key":"Description","value":"-"}]},{"database":"GO","id":"GO:0003677","properties":[{"key":"GoTerm","value":"F:DNA binding"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniRule"}]},{"database":"GO","id":"GO:0000160","properties":[{"key":"GoTerm","value":"P:phosphorelay signal transduction system"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0006355","properties":[{"key":"GoTerm","value":"P:regulation of DNA-templated transcription"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"Gene3D","id":"1.10.10.10","properties":[{"key":"EntryName","value":"Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR001867","properties":[{"key":"EntryName","value":"OmpR/PhoB-type_DNA-bd"}]},{"database":"InterPro","id":"IPR016032","properties":[{"key":"EntryName","value":"Sig_transdc_resp-reg_C-effctor"}]},{"database":"InterPro","id":"IPR036388","properties":[{"key":"EntryName","value":"WH-like_DNA-bd_sf"}]},{"database":"Pfam","id":"PF00486","properties":[{"key":"EntryName","value":"Trans_reg_C"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF46894","properties":[{"key":"EntryName","value":"C-terminal effector domain of the bipartite response regulators"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS51755","properties":[{"key":"EntryName","value":"OMPR_PHOB"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"EQGFEVDDSSLTQSISTLRKSLKDSTKSPMFVKTVPKRGYQVVCSVEVYNEQEVELPEPAASVIDETAAKKEPELLSDNTAQTLPLPDAVAEQTEPKVSTNATAPAKMPLGSWVALVLTLLVPLAFQIASNPNPKSEAFREILTIENVPVYIPVTNARISQWQPMVQRCVEKYIGFYGKERELEEVIATRGQN","length":193,"molWeight":21335,"crc64":"7D5A4563B908E18F","md5":"5A056220E0A0989DF835F9AB380E835C"},"extraAttributes":{"countByFeatureType":{"Transmembrane":1,"Domain":1,"DNA binding":1,"Non-terminal residue":2},"uniParcId":"UPI00000B7741"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"Q9RHQ9","uniProtkbId":"Q9RHQ9_GRIHO","entryAudit":{"firstPublicDate":"2000-05-01","lastAnnotationUpdateDate":"2026-11-04","lastSequenceUpdateDate":"2000-05-01","entryVersion":105,"sequenceVersion":1},"annotationScore":1.0,"organism":{"scientificName":"Grimontia hollisae","commonName":"Vibrio hollisae","taxonId":673,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"BAA89010.1"}],"lineage":["Bacteria","Pseudomonadati","Pseudomonadota","Gammaproteobacteria","Vibrionales","Vibrionaceae","Grimontia"]},"proteinExistence":"4: Predicted","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"STO56958.1"}],"value":"Transcriptional activator CadC"}},{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"BAA89010.1"}],"value":"Transmembrane regulatory protein ToxR"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"BAA89010.1"}],"value":"toxR"},"synonyms":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"STO56958.1"}],"value":"cadC"}],"orfNames":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"STO56958.1"}],"value":"NCTC11645_01334"}]}],"features":[{"type":"Transmembrane","location":{"start":{"value":175,"modifier":"EXACT"},"end":{"value":194,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Domain","location":{"start":{"value":5,"modifier":"EXACT"},"end":{"value":109,"modifier":"EXACT"}},"description":"OmpR/PhoB-type","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS51755"}]},{"type":"DNA binding","location":{"start":{"value":5,"modifier":"EXACT"},"end":{"value":109,"modifier":"EXACT"}},"description":"OmpR/PhoB-type","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU01091"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023125"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU01091"}],"id":"KW-0238","category":"Molecular function","name":"DNA-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"},{"evidenceCode":"ECO:0000313","source":"EMBL","id":"BAA89010.1"}],"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-1133","category":"Domain","name":"Transmembrane helix"}],"references":[{"referenceNumber":1,"citation":{"id":"10919814","citationType":"journal article","authors":["Vuddhakul V.","Nakai T.","Matsumoto C.","Oh T.","Nishino T.","Chen C.H.","Nishibuchi M.","Okuda J."],"citationCrossReferences":[{"database":"PubMed","id":"10919814"},{"database":"DOI","id":"10.1128/AEM.66.8.3506-3514.2000"}],"title":"Analysis of gyrB and toxR gene sequences of Vibrio hollisae and development of gyrB- and toxR-targeted PCR methods for isolation of V. hollisae from the environment and its identification.","publicationDate":"2000","journal":"Appl. Environ. Microbiol.","firstPage":"3506","lastPage":"3514","volume":"66"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"BAA89010.1"}],"value":"525-82","type":"STRAIN"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"BAA89010.1"}]},{"referenceNumber":2,"citation":{"id":"CI-AB4PR2KKK46L9","citationType":"submission","authoringGroup":["Pathogen Informatics"],"authors":["Doyle S."],"publicationDate":"JUN-2018","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"STO56958.1"}],"value":"NCTC11645","type":"STRAIN"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"STO56958.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AB027503","properties":[{"key":"ProteinId","value":"BAA89010.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"UGHD01000002","properties":[{"key":"ProteinId","value":"STO56958.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"RefSeq","id":"WP_114994980.1","properties":[{"key":"NucleotideSequenceId","value":"NZ_CABMOB010000001.1"}]},{"database":"AlphaFoldDB","id":"Q9RHQ9","properties":[{"key":"Description","value":"-"}]},{"database":"STRING","id":"673.AL542_04590","properties":[{"key":"Description","value":"-"}]},{"database":"GO","id":"GO:0003677","properties":[{"key":"GoTerm","value":"F:DNA binding"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniRule"}]},{"database":"GO","id":"GO:0000160","properties":[{"key":"GoTerm","value":"P:phosphorelay signal transduction system"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0006355","properties":[{"key":"GoTerm","value":"P:regulation of DNA-templated transcription"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"CDD","id":"cd00383","properties":[{"key":"EntryName","value":"trans_reg_C"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.10.10.10","properties":[{"key":"EntryName","value":"Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR001867","properties":[{"key":"EntryName","value":"OmpR/PhoB-type_DNA-bd"}]},{"database":"InterPro","id":"IPR016032","properties":[{"key":"EntryName","value":"Sig_transdc_resp-reg_C-effctor"}]},{"database":"InterPro","id":"IPR036388","properties":[{"key":"EntryName","value":"WH-like_DNA-bd_sf"}]},{"database":"Pfam","id":"PF00486","properties":[{"key":"EntryName","value":"Trans_reg_C"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00862","properties":[{"key":"EntryName","value":"Trans_reg_C"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF46894","properties":[{"key":"EntryName","value":"C-terminal effector domain of the bipartite response regulators"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS51755","properties":[{"key":"EntryName","value":"OMPR_PHOB"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MLNKSNRYLLGERFVFSPSDSSLIDLYENDDLIRLGSNECRVLMVLIEEPHAIVTRNRIHDFVWRKQGFEVDDSSLTQSISTLRKSLKDSTKSPMFVKTVPKRGYQVVCSVEVYNEQEVELPEPAASVIDETAAKTEPELLSDNTAQTLPLPDAVAEQTEPKVSTNATAPAKMPLGSWVALVLTLLVPLAFQIASNPNPKSEAFREILTIENVPVYIPVTNARISQWQPMVQRCVEKYIGFYGKERELEEVIVTGGQDNHISLNYIHSAKDADDNITYVLLTSQQGSDAICR","length":292,"molWeight":32686,"crc64":"501B97AAB1E9B56E","md5":"407B787DCAAAD1BBF709D7BF87B8959C"},"extraAttributes":{"countByFeatureType":{"Transmembrane":1,"Domain":1,"DNA binding":1},"uniParcId":"UPI00000BBE1B"}}]}