{"results":[{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0A1B0UTS4","uniProtkbId":"A0A1B0UTS4_9ACTN","entryAudit":{"firstPublicDate":"2016-11-02","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2016-11-02","entryVersion":19,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Actinomadura viridilutea","taxonId":58112,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AMH86070.1"}],"lineage":["Bacteria","Bacillati","Actinomycetota","Actinomycetes","Streptosporangiales","Thermomonosporaceae","Actinomadura"]},"proteinExistence":"3: Inferred from homology","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AMH86070.1"}],"value":"Serine alkaline keratinolytic protease KerDZ preproprotein"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AMH86070.1"}],"value":"kerDZ"}}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00007664"}],"value":"Belongs to the peptidase S1 family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Signal","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":29,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}]},{"type":"Chain","location":{"start":{"value":30,"modifier":"EXACT"},"end":{"value":384,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"featureId":"PRO_5008517265"},{"type":"Domain","location":{"start":{"value":62,"modifier":"EXACT"},"end":{"value":123,"modifier":"EXACT"}},"description":"Alpha-lytic protease pro N-terminal","evidences":[{"evidenceCode":"ECO:0000259","source":"Pfam","id":"PF28778"}]},{"type":"Domain","location":{"start":{"value":125,"modifier":"EXACT"},"end":{"value":181,"modifier":"EXACT"}},"description":"Peptidase S1A alpha-lytic prodomain","evidences":[{"evidenceCode":"ECO:0000259","source":"Pfam","id":"PF02983"}]},{"type":"Active site","location":{"start":{"value":231,"modifier":"EXACT"},"end":{"value":231,"modifier":"EXACT"}},"description":"Charge relay system","evidences":[{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR001134-1"}]},{"type":"Active site","location":{"start":{"value":257,"modifier":"EXACT"},"end":{"value":257,"modifier":"EXACT"}},"description":"Charge relay system","evidences":[{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR001134-1"}]},{"type":"Active site","location":{"start":{"value":339,"modifier":"EXACT"},"end":{"value":339,"modifier":"EXACT"}},"description":"Charge relay system","evidences":[{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR001134-1"}]},{"type":"Disulfide bond","location":{"start":{"value":211,"modifier":"EXACT"},"end":{"value":232,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR001134-2"}]},{"type":"Disulfide bond","location":{"start":{"value":297,"modifier":"EXACT"},"end":{"value":307,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR001134-2"}]},{"type":"Disulfide bond","location":{"start":{"value":333,"modifier":"EXACT"},"end":{"value":360,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR001134-2"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023157"},{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR001134-2"}],"id":"KW-1015","category":"PTM","name":"Disulfide bond"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022801"}],"id":"KW-0378","category":"Molecular function","name":"Hydrolase"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022670"},{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AMH86070.1"}],"id":"KW-0645","category":"Molecular function","name":"Protease"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022825"}],"id":"KW-0720","category":"Molecular function","name":"Serine protease"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022729"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"id":"KW-0732","category":"Domain","name":"Signal"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023145"}],"id":"KW-0865","category":"PTM","name":"Zymogen"}],"references":[{"referenceNumber":1,"citation":{"id":"27387016","citationType":"journal article","authors":["Elhoul M.B.","Jaouadi N.Z.","Rekik H.","Benmrad M.O.","Mechri S.","Moujehed E.","Kourdali S.","Hattab M.E.","Badis A.","Bejar S.","Jaouadi B."],"citationCrossReferences":[{"database":"PubMed","id":"27387016"}],"title":"Biochemical and molecular characterization of new keratinoytic protease from Actinomadura viridilutea DZ50.","publicationDate":"2016","journal":"Int. J. Biol. Macromol.","firstPage":"0","lastPage":"0","volume":"0"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AMH86070.1"}],"value":"DZ50","type":"STRAIN"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AMH86070.1"}]},{"referenceNumber":2,"citation":{"id":"CI-GP3KMMQ3ELTJ","citationType":"submission","authors":["Oliw E.H."],"publicationDate":"JAN-2016","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AMH86070.1"}],"value":"DZ50","type":"STRAIN"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AMH86070.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"KU550701","properties":[{"key":"ProteinId","value":"AMH86070.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"AlphaFoldDB","id":"A0A1B0UTS4","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"A0A1B0UTS4","properties":[{"key":"Description","value":"-"}]},{"database":"GO","id":"GO:0005576","properties":[{"key":"GoTerm","value":"C:extracellular region"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0004252","properties":[{"key":"GoTerm","value":"F:serine-type endopeptidase activity"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0006508","properties":[{"key":"GoTerm","value":"P:proteolysis"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"CDD","id":"cd21112","properties":[{"key":"EntryName","value":"alphaLP-like"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.30.300.50","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"2"}]},{"database":"Gene3D","id":"2.40.10.10","properties":[{"key":"EntryName","value":"Trypsin-like serine proteases"},{"key":"MatchStatus","value":"2"}]},{"database":"InterPro","id":"IPR004236","properties":[{"key":"EntryName","value":"Pept_S1_alpha_lytic"}]},{"database":"InterPro","id":"IPR001316","properties":[{"key":"EntryName","value":"Pept_S1A_streptogrisin"}]},{"database":"InterPro","id":"IPR009003","properties":[{"key":"EntryName","value":"Peptidase_S1_PA"}]},{"database":"InterPro","id":"IPR063705","properties":[{"key":"EntryName","value":"Pro_N"}]},{"database":"InterPro","id":"IPR035070","properties":[{"key":"EntryName","value":"Streptogrisin_prodomain"}]},{"database":"Pfam","id":"PF02983","properties":[{"key":"EntryName","value":"Pro_Al_protease"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF28778","properties":[{"key":"EntryName","value":"Pro_N"},{"key":"MatchStatus","value":"1"}]},{"database":"PIRSF","id":"PIRSF001134","properties":[{"key":"EntryName","value":"Streptogrisin"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR00861","properties":[{"key":"EntryName","value":"ALYTICPTASE"}]},{"database":"SUPFAM","id":"SSF50494","properties":[{"key":"EntryName","value":"Trypsin-like serine proteases"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MRPSPVVSAIGTEALAFGLALAAAPGALAASGPLPQSPSPDSDVATTMAEALERDLNLTSAEAQELLTAQEAAFEADEAAAQAAGDAYGGSVFDTETLELTVMVTDAAAVQAVEATGAKADVVSHGLDGLEAVIDDLNEAAHQPGVVGWYPDITSDTVVLEVLEGAEADAEALIADAGVDASTVTIETTTQSPELYADIRAGLAYTMGGRCSVGNAATNASGQPGFYTAGHCGSVGTQVSIGNGRGVFERSVFPGNDAAWVRGTSNWTLTNLVSRYNSGFYATQSGSSTAPIGSQVCRSGSTTGWHCGTIQARNQTVSYPQGTLHSLIRTSVCAEPGDSAGSFISGTQSQGVTSGGSGNCRTGGTTFYQDVNPMLNSWNIRLRT","length":384,"molWeight":39102,"crc64":"937C75860956BCFC","md5":"A0B6F3364DEB1DF7572C653C962CE6B5"},"extraAttributes":{"countByCommentType":{"SIMILARITY":1},"countByFeatureType":{"Signal":1,"Chain":1,"Domain":2,"Active site":3,"Disulfide bond":3},"uniParcId":"UPI000809396B"}}]}