{"results":[{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"Q8RMC0","uniProtkbId":"MSP_TRELE","entryAudit":{"firstPublicDate":"2002-07-26","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2002-06-01","entryVersion":49,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Treponema lecithinolyticum","taxonId":53418,"lineage":["Bacteria","Pseudomonadati","Spirochaetota","Spirochaetia","Treponematales","Treponemataceae","Treponema"]},"proteinExistence":"3: Inferred from homology","proteinDescription":{"recommendedName":{"fullName":{"value":"Major surface protein MspTL"}},"flag":"Precursor"},"genes":[{"geneName":{"value":"mspTL"}}],"comments":[{"texts":[{"value":"Major component of the outer membrane"}],"commentType":"FUNCTION"},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"value":"Cell outer membrane","id":"SL-0040"},"topology":{"value":"Peripheral membrane protein","id":"SL-9903"}}]}],"features":[{"type":"Signal","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":19,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Chain","location":{"start":{"value":20,"modifier":"EXACT"},"end":{"value":590,"modifier":"EXACT"}},"description":"Major surface protein MspTL","featureId":"PRO_0000021772"}],"keywords":[{"id":"KW-0998","category":"Cellular component","name":"Cell outer membrane"},{"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"id":"KW-0732","category":"Domain","name":"Signal"}],"references":[{"referenceNumber":1,"citation":{"id":"11958938","citationType":"journal article","authors":["Park K.-K.","Heuner K.","Goebel U.B.","Yoo Y.-J.","Kim C.-K.","Choi B.-K."],"citationCrossReferences":[{"database":"PubMed","id":"11958938"},{"database":"DOI","id":"10.1111/j.1574-6968.2002.tb11049.x"}],"title":"Cloning and characterization of a major surface protein (MspTL) of Treponema lecithinolyticum associated with rapidly progressive periodontitis.","publicationDate":"2002","journal":"FEMS Microbiol. Lett.","firstPage":"185","lastPage":"192","volume":"207"},"referencePositions":["NUCLEOTIDE SEQUENCE [GENOMIC DNA]"],"referenceComments":[{"value":"ATCC 700332 / CIP 107075 / OMZ 684 / PFB4G","type":"STRAIN"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AY026951","properties":[{"key":"ProteinId","value":"AAK11483.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"TCDB","id":"1.B.38.3.3","properties":[{"key":"FamilyName","value":"the treponema porin major surface protein (tp-msp) family"}]},{"database":"GO","id":"GO:0009279","properties":[{"key":"GoTerm","value":"C:cell outer membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]}],"sequence":{"value":"MKKILAFFLVFALAGAVFADEPSAEAKIAEFKGDAAVTFGVDLDTNRTGFKNEVGGSIKLNLLNGGDKSTTGDGIWGELKLKINAFTLQAKADKNVNLLTKIDDDDVKVEIDTAKIHIGPAYVGIKKGDLNYGSNFWYPNALNYKDGDDEYYNRTPSDKVKYDQGLVLGYEQKDLFKVETAFRSQKDTGKKLDKVEGVILPKDTEIKKGEYFKSVEGAHDNAKTDDVFDDAALVDPIPGKTDVKKLKATXAVFKRVMKDGDTNYWTDKYALGVYGEVKPIKDLRVAIGTAYVFGRLSGDKDVLKAVGDSDNRGDITFFTGAXYKLSLLEKFVVNPVVTYTLYADAKWNGANEKLXYPEXLKTSMLKTGVRFGWGEXKKSNSLLYDFXGKNTLVYDTNKEDKGDDKLLPGVSLFGAFDLVNKNIETKLPLMXTFYSGELVKGLNVAALVHANVAKDASEISRVVPGTVYAGRMTKAXYERLIGAKGLQIGLAASYDVKLNDITIVPAAAMLWTHGMLKGEADTRMTADEFKVEAKVDVKGVIQNTTLSVFWDEAAFGKGTSKEWTFGVKHDEQNYYTLKNGVFGLKAKIAL","length":590,"molWeight":64892,"crc64":"19C0C633D4BCAC74","md5":"1BC5FD511414672123BE287ACB5A8A0E"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"SUBCELLULAR LOCATION":1},"countByFeatureType":{"Signal":1,"Chain":1},"uniParcId":"UPI000012F642"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0AA82WPE8","uniProtkbId":"A0AA82WPE8_TRELE","entryAudit":{"firstPublicDate":"2024-03-27","lastAnnotationUpdateDate":"2026-11-04","lastSequenceUpdateDate":"2024-03-27","entryVersion":12,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Treponema lecithinolyticum","taxonId":53418,"evidences":[{"evidenceCode":"ECO:0000313","source":"PDB","id":"8DHW"}],"lineage":["Bacteria","Pseudomonadati","Spirochaetota","Spirochaetia","Treponematales","Treponemataceae","Treponema"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00016205"}],"value":"Beta-glucuronidase"},"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00012761"}],"value":"3.2.1.31"}]}},"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00007401"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU361154"}],"value":"Belongs to the glycosyl hydrolase 2 family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Domain","location":{"start":{"value":14,"modifier":"EXACT"},"end":{"value":188,"modifier":"EXACT"}},"description":"Glycosyl hydrolases family 2 sugar binding","evidences":[{"evidenceCode":"ECO:0000259","source":"Pfam","id":"PF02837"}]},{"type":"Domain","location":{"start":{"value":191,"modifier":"EXACT"},"end":{"value":279,"modifier":"EXACT"}},"description":"Glycoside hydrolase family 2 immunoglobulin-like beta-sandwich","evidences":[{"evidenceCode":"ECO:0000259","source":"Pfam","id":"PF00703"}]},{"type":"Domain","location":{"start":{"value":281,"modifier":"EXACT"},"end":{"value":600,"modifier":"EXACT"}},"description":"Glycoside hydrolase family 2 catalytic","evidences":[{"evidenceCode":"ECO:0000259","source":"Pfam","id":"PF02836"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8DHV"},{"evidenceCode":"ECO:0007829","source":"PDB","id":"8DHW"}],"id":"KW-0002","category":"Technical term","name":"3D-structure"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023295"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU361154"}],"id":"KW-0326","category":"Molecular function","name":"Glycosidase"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022801"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU361154"}],"id":"KW-0378","category":"Molecular function","name":"Hydrolase"}],"references":[{"referenceNumber":1,"citation":{"id":"37146137","citationType":"journal article","authors":["Lietzan A.D.","Simpson J.B.","Walton W.G.","Jariwala P.B.","Xu Y.","Boynton M.H.","Liu J.","Redinbo M.R."],"citationCrossReferences":[{"database":"PubMed","id":"37146137"},{"database":"DOI","id":"10.1126/sciadv.adg3390"}],"title":"Microbial beta-glucuronidases drive human periodontal disease etiology.","publicationDate":"2023","journal":"Sci. Adv.","firstPage":"eadg3390","lastPage":"eadg3390","volume":"9"},"referencePositions":["X-RAY CRYSTALLOGRAPHY (1.60 ANGSTROMS) OF 11-607"],"evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8DHV"},{"evidenceCode":"ECO:0007829","source":"PDB","id":"8DHW"}]}],"uniProtKBCrossReferences":[{"database":"PDB","id":"8DHV","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.60 A"},{"key":"Chains","value":"A/B=11-607"}]},{"database":"PDB","id":"8DHW","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.75 A"},{"key":"Chains","value":"A/B=11-607"}]},{"database":"PDB","id":"8E72","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.95 A"},{"key":"Chains","value":"A/B=11-607"}]},{"database":"AlphaFoldDB","id":"A0AA82WPE8","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"A0AA82WPE8","properties":[{"key":"Description","value":"-"}]},{"database":"CAZy","id":"GH2","properties":[{"key":"FamilyName","value":"Glycoside Hydrolase Family 2"}]},{"database":"GO","id":"GO:0004566","properties":[{"key":"GoTerm","value":"F:beta-glucuronidase activity"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-EC"}]},{"database":"GO","id":"GO:0030246","properties":[{"key":"GoTerm","value":"F:carbohydrate binding"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:0005975","properties":[{"key":"GoTerm","value":"P:carbohydrate metabolic process"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0019391","properties":[{"key":"GoTerm","value":"P:glucuronoside catabolic process"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"FunFam","id":"3.20.20.80:FF:000080","properties":[{"key":"EntryName","value":"Beta-glucuronidase UidA"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.60.120.260","properties":[{"key":"EntryName","value":"Galactose-binding domain-like"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.20.20.80","properties":[{"key":"EntryName","value":"Glycosidases"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.60.40.10","properties":[{"key":"EntryName","value":"Immunoglobulins"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR036156","properties":[{"key":"EntryName","value":"Beta-gal/glucu_dom_sf"}]},{"database":"InterPro","id":"IPR008979","properties":[{"key":"EntryName","value":"Galactose-bd-like_sf"}]},{"database":"InterPro","id":"IPR017853","properties":[{"key":"EntryName","value":"GH_hydrolase_sf"}]},{"database":"InterPro","id":"IPR006101","properties":[{"key":"EntryName","value":"Glyco_hydro_2"}]},{"database":"InterPro","id":"IPR023232","properties":[{"key":"EntryName","value":"Glyco_hydro_2_AS"}]},{"database":"InterPro","id":"IPR006103","properties":[{"key":"EntryName","value":"Glyco_hydro_2_cat"}]},{"database":"InterPro","id":"IPR023230","properties":[{"key":"EntryName","value":"Glyco_hydro_2_CS"}]},{"database":"InterPro","id":"IPR006104","properties":[{"key":"EntryName","value":"Glyco_hydro_2_N"}]},{"database":"InterPro","id":"IPR013783","properties":[{"key":"EntryName","value":"Ig-like_fold"}]},{"database":"InterPro","id":"IPR006102","properties":[{"key":"EntryName","value":"Ig-like_GH2"}]},{"database":"NCBIfam","id":"NF007538","properties":[{"key":"EntryName","value":"uidA"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR10066","properties":[{"key":"EntryName","value":"BETA-GLUCURONIDASE"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR10066:SF67","properties":[{"key":"EntryName","value":"BETA-GLUCURONIDASE"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00703","properties":[{"key":"EntryName","value":"Glyco_hydro_2"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF02836","properties":[{"key":"EntryName","value":"Glyco_hydro_2_C"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF02837","properties":[{"key":"EntryName","value":"Glyco_hydro_2_N"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR00132","properties":[{"key":"EntryName","value":"GLHYDRLASE2"}]},{"database":"SUPFAM","id":"SSF51445","properties":[{"key":"EntryName","value":"(Trans)glycosidases"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF49303","properties":[{"key":"EntryName","value":"beta-Galactosidase/glucuronidase domain"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF49785","properties":[{"key":"EntryName","value":"Galactose-binding domain-like"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00719","properties":[{"key":"EntryName","value":"GLYCOSYL_HYDROL_F2_1"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00608","properties":[{"key":"EntryName","value":"GLYCOSYL_HYDROL_F2_2"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MLYPILTQSRMLIDLSGTWRFKLDDGSGFEKKWYEKTLDDAQLMPVPSSYNDIKESADLRDHYGWVFYQRDLNIPAYLKTQRIVLRFAAVTHSAKVYVNGTLLCEHKGGFLPFETEIPENLIRDENLLTVAVDNRIDHSTLPVGREDESNVLGGSFFPYTPTKKQNKPNFDFFNYCGITRPVKLYTTPKDAYISDITLTSSLENNTARINYKIDTKGSAHTAIGVYTKQGVCVAQTENTGTEGSLTIENAVLWEPLKPYLYEVKISFGEDRYTLPYGIRSVAVKGNKFLINNKPFYFKGYGKHEDTFPAGRGLNMPMNAKDISLMKWQGANSFRTSHYPYSEEMMRLCDEEGIVVIDETTAVGVHLNFGGGAALKDGKRVNTFDPIEQGGIRTQSHHKEVIKDLIARDKNHACVVMWSIANEADTGSKGAYEYFKPLFDLARELDPQKRPCTLVSLQMVNYKEDCTIKLSDVFCLNRYYGWYTCGADLQAAEKMCREELEFWNSLGKPFMYTEYGADTVMGLHDTTDSMFTEEYQVEYYKTNHKVTDTLDCFIGEQVWNFADFATSQGLIRVQGNKKGLFTRDRKPKLAAHYFKERWSKIPDFGYKK","length":607,"molWeight":69402,"crc64":"79418E4C463534BD","md5":"DED087651817B2E7E591326E0B186619"},"extraAttributes":{"countByCommentType":{"SIMILARITY":1},"countByFeatureType":{"Domain":3},"uniParcId":"UPI0003FF746A"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"Q6UKM7","uniProtkbId":"Q6UKM7_TRELE","entryAudit":{"firstPublicDate":"2004-07-05","lastAnnotationUpdateDate":"2026-11-04","lastSequenceUpdateDate":"2004-07-05","entryVersion":94,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Treponema lecithinolyticum","taxonId":53418,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAQ73564.2"}],"lineage":["Bacteria","Pseudomonadati","Spirochaetota","Spirochaetia","Treponematales","Treponemataceae","Treponema"]},"proteinExistence":"3: Inferred from homology","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAQ73564.2"}],"value":"PrtPII"}}]},"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00011073"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU01240"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003355"}],"value":"Belongs to the peptidase S8 family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Signal","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":27,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}]},{"type":"Chain","location":{"start":{"value":28,"modifier":"EXACT"},"end":{"value":627,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00303"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"featureId":"PRO_5051002272"},{"type":"Domain","location":{"start":{"value":210,"modifier":"EXACT"},"end":{"value":520,"modifier":"EXACT"}},"description":"Peptidase S8/S53","evidences":[{"evidenceCode":"ECO:0000259","source":"Pfam","id":"PF00082"}]},{"type":"Region","location":{"start":{"value":141,"modifier":"EXACT"},"end":{"value":174,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Active site","location":{"start":{"value":215,"modifier":"EXACT"},"end":{"value":215,"modifier":"EXACT"}},"description":"Charge relay system","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU10080"}]},{"type":"Active site","location":{"start":{"value":265,"modifier":"EXACT"},"end":{"value":265,"modifier":"EXACT"}},"description":"Charge relay system","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU10081"}]},{"type":"Active site","location":{"start":{"value":463,"modifier":"EXACT"},"end":{"value":463,"modifier":"EXACT"}},"description":"Charge relay system","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU10082"}]},{"type":"Lipidation","location":{"start":{"value":28,"modifier":"EXACT"},"end":{"value":28,"modifier":"EXACT"}},"description":"N-palmitoyl cysteine","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00303"}]},{"type":"Lipidation","location":{"start":{"value":28,"modifier":"EXACT"},"end":{"value":28,"modifier":"EXACT"}},"description":"S-diacylglycerol cysteine","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00303"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022801"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU01240"}],"id":"KW-0378","category":"Molecular function","name":"Hydrolase"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00303"}],"id":"KW-0449","category":"PTM","name":"Lipoprotein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00303"}],"id":"KW-0564","category":"PTM","name":"Palmitate"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022670"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU01240"}],"id":"KW-0645","category":"Molecular function","name":"Protease"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022825"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU01240"}],"id":"KW-0720","category":"Molecular function","name":"Serine protease"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00303"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"id":"KW-0732","category":"Domain","name":"Signal"}],"references":[{"referenceNumber":1,"citation":{"id":"14617650","citationType":"journal article","authors":["Correia F.F.","Plummer A.R.","Ellen R.P.","Wyss C.","Boches S.K.","Galvin J.L.","Paster B.J.","Dewhirst F.E."],"citationCrossReferences":[{"database":"PubMed","id":"14617650"},{"database":"DOI","id":"10.1128/JB.185.23.6860-6869.2003"}],"title":"Two paralogous families of a two-gene subtilisin operon are widely distributed in oral treponemes.","publicationDate":"2003","journal":"J. Bacteriol.","firstPage":"6860","lastPage":"6869","volume":"185"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAQ73564.2"}],"value":"OMZ 684","type":"STRAIN"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAQ73564.2"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AY368071","properties":[{"key":"ProteinId","value":"AAQ73564.2"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"AlphaFoldDB","id":"Q6UKM7","properties":[{"key":"Description","value":"-"}]},{"database":"MEROPS","id":"S08.024","properties":[{"key":"Description","value":"-"}]},{"database":"GO","id":"GO:0004252","properties":[{"key":"GoTerm","value":"F:serine-type endopeptidase activity"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniRule"}]},{"database":"GO","id":"GO:0006508","properties":[{"key":"GoTerm","value":"P:proteolysis"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"Gene3D","id":"3.40.50.200","properties":[{"key":"EntryName","value":"Peptidase S8/S53 domain"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR000209","properties":[{"key":"EntryName","value":"Peptidase_S8/S53_dom"}]},{"database":"InterPro","id":"IPR036852","properties":[{"key":"EntryName","value":"Peptidase_S8/S53_dom_sf"}]},{"database":"InterPro","id":"IPR023827","properties":[{"key":"EntryName","value":"Peptidase_S8_Asp-AS"}]},{"database":"InterPro","id":"IPR022398","properties":[{"key":"EntryName","value":"Peptidase_S8_His-AS"}]},{"database":"InterPro","id":"IPR023828","properties":[{"key":"EntryName","value":"Peptidase_S8_Ser-AS"}]},{"database":"InterPro","id":"IPR050131","properties":[{"key":"EntryName","value":"Peptidase_S8_subtilisin-like"}]},{"database":"InterPro","id":"IPR015500","properties":[{"key":"EntryName","value":"Peptidase_S8_subtilisin-rel"}]},{"database":"NCBIfam","id":"NF033595","properties":[{"key":"EntryName","value":"denti_PrtP"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR43806:SF11","properties":[{"key":"EntryName","value":"CEREVISIN-RELATED"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR43806","properties":[{"key":"EntryName","value":"PEPTIDASE S8"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00082","properties":[{"key":"EntryName","value":"Peptidase_S8"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR00723","properties":[{"key":"EntryName","value":"SUBTILISIN"}]},{"database":"SUPFAM","id":"SSF52743","properties":[{"key":"EntryName","value":"Subtilisin-like"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS51257","properties":[{"key":"EntryName","value":"PROKAR_LIPOPROTEIN"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS51892","properties":[{"key":"EntryName","value":"SUBTILASE"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00136","properties":[{"key":"EntryName","value":"SUBTILASE_ASP"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00137","properties":[{"key":"EntryName","value":"SUBTILASE_HIS"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00138","properties":[{"key":"EntryName","value":"SUBTILASE_SER"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MHKKHVFAVKAVVVLLVSASFAVLLAGCPAGFIQTGKGGTSGVSGSTARPFGAEWISEQQERRDENEKVNKDYSIVKAARFVNGDSFAALNGSVESTLDLHDGYVYFLVKSAGDAAQFRDAVRKLDGILYAQPDYQYEAPQAMQSDDQPPYRTPKTISSAHSGSVKPLGTKDGDVNEDPKAALADWGLTVTHALEAFKEYDASDAKHPVLAAIVDSGVNGLHEDFYDAHGSIILYAKSSLHKGSSAEYNPLQIIPINDNWDDVGHGTHCAGTIAAVGNNGKGICGVSHANTKLITYRGLGKTGGSSYSVYSCLGDLAQIISELRKEPGSRNPALFAGLPAEVSAYPKLTQKTVPVNISLGGYSIHPYEVEMMNKALAAGVLPVIAMANDGKTVASYPAALQGVLAVGATSMDDTKAAFSNGGSWISVCAPGDSIYSCYNNGTNWSNTAAPELRKSYTWMSGTSMATPFVTGTLTYLLSIDPNISPYQIKTLLENTADKIDQLSPYGKYDVRGFSKWYGYGRVNVLKAAQAIKSGSVPAEGSRYSEKAVIITVKKGGIAQKKKTVWLYEKPNGICASVGITDENNGTIRFYGLRTNTEYEIGINDAGTYKTLAVSAPGYTDTSYDFNL","length":627,"molWeight":66898,"crc64":"8C9BB875D7C8C03F","md5":"BEAAA42A0100C1E8B08A39EB844A24F2"},"extraAttributes":{"countByCommentType":{"SIMILARITY":1},"countByFeatureType":{"Signal":1,"Chain":1,"Domain":1,"Region":1,"Active site":3,"Lipidation":2},"uniParcId":"UPI00001CE5DA"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"Q8VLY3","uniProtkbId":"Q8VLY3_TRELE","entryAudit":{"firstPublicDate":"2002-03-01","lastAnnotationUpdateDate":"2026-11-04","lastSequenceUpdateDate":"2002-03-01","entryVersion":79,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Treponema lecithinolyticum","taxonId":53418,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"CAC81267.1"}],"lineage":["Bacteria","Pseudomonadati","Spirochaetota","Spirochaetia","Treponematales","Treponemataceae","Treponema"]},"proteinExistence":"3: Inferred from homology","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"CAC81267.1"}],"value":"Chymotrypsin-like proteinase"}}],"flag":"Fragment"},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"CAC81267.1"}],"value":"prtP"}}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00011073"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU01240"}],"value":"Belongs to the peptidase S8 family"}],"commentType":"SIMILARITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU01240"}],"value":"Lacks conserved residue(s) required for the propagation of feature annotation"}],"commentType":"CAUTION"}],"features":[{"type":"Signal","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":18,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}]},{"type":"Chain","location":{"start":{"value":19,"modifier":"EXACT"},"end":{"value":427,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00303"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"featureId":"PRO_5004315179"},{"type":"Domain","location":{"start":{"value":178,"modifier":"EXACT"},"end":{"value":416,"modifier":"EXACT"}},"description":"Peptidase S8/S53","evidences":[{"evidenceCode":"ECO:0000259","source":"Pfam","id":"PF00082"}]},{"type":"Active site","location":{"start":{"value":186,"modifier":"EXACT"},"end":{"value":186,"modifier":"EXACT"}},"description":"Charge relay system","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU10080"}]},{"type":"Active site","location":{"start":{"value":241,"modifier":"EXACT"},"end":{"value":241,"modifier":"EXACT"}},"description":"Charge relay system","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU10081"}]},{"type":"Lipidation","location":{"start":{"value":19,"modifier":"EXACT"},"end":{"value":19,"modifier":"EXACT"}},"description":"N-palmitoyl cysteine","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00303"}]},{"type":"Lipidation","location":{"start":{"value":19,"modifier":"EXACT"},"end":{"value":19,"modifier":"EXACT"}},"description":"S-diacylglycerol cysteine","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00303"}]},{"type":"Non-terminal residue","location":{"start":{"value":427,"modifier":"EXACT"},"end":{"value":427,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"CAC81267.1"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022801"}],"id":"KW-0378","category":"Molecular function","name":"Hydrolase"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00303"}],"id":"KW-0449","category":"PTM","name":"Lipoprotein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00303"}],"id":"KW-0564","category":"PTM","name":"Palmitate"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022670"}],"id":"KW-0645","category":"Molecular function","name":"Protease"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022825"}],"id":"KW-0720","category":"Molecular function","name":"Serine protease"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00303"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"id":"KW-0732","category":"Domain","name":"Signal"}],"references":[{"referenceNumber":1,"citation":{"id":"11470357","citationType":"journal article","authors":["Heuner K.","Bergmann I.","Heckenbach K.","Goebel U.B."],"citationCrossReferences":[{"database":"PubMed","id":"11470357"}],"title":"Proteolytic activity among various oral Treponema species and cloning of a prtP-like gene of Treponema socranskii subsp. socranskii.","publicationDate":"2001","journal":"FEMS Microbiol. Lett.","firstPage":"169","lastPage":"176","volume":"201"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"CAC81267.1"}],"value":"ATCC 700332","type":"STRAIN"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"CAC81267.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AJ272340","properties":[{"key":"ProteinId","value":"CAC81267.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"AlphaFoldDB","id":"Q8VLY3","properties":[{"key":"Description","value":"-"}]},{"database":"MEROPS","id":"S08.024","properties":[{"key":"Description","value":"-"}]},{"database":"GO","id":"GO:0004252","properties":[{"key":"GoTerm","value":"F:serine-type endopeptidase activity"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0006508","properties":[{"key":"GoTerm","value":"P:proteolysis"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"Gene3D","id":"3.40.50.200","properties":[{"key":"EntryName","value":"Peptidase S8/S53 domain"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR000209","properties":[{"key":"EntryName","value":"Peptidase_S8/S53_dom"}]},{"database":"InterPro","id":"IPR036852","properties":[{"key":"EntryName","value":"Peptidase_S8/S53_dom_sf"}]},{"database":"InterPro","id":"IPR023827","properties":[{"key":"EntryName","value":"Peptidase_S8_Asp-AS"}]},{"database":"InterPro","id":"IPR022398","properties":[{"key":"EntryName","value":"Peptidase_S8_His-AS"}]},{"database":"InterPro","id":"IPR050131","properties":[{"key":"EntryName","value":"Peptidase_S8_subtilisin-like"}]},{"database":"InterPro","id":"IPR015500","properties":[{"key":"EntryName","value":"Peptidase_S8_subtilisin-rel"}]},{"database":"NCBIfam","id":"NF033595","properties":[{"key":"EntryName","value":"denti_PrtP"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR43806:SF11","properties":[{"key":"EntryName","value":"CEREVISIN-RELATED"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR43806","properties":[{"key":"EntryName","value":"PEPTIDASE S8"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00082","properties":[{"key":"EntryName","value":"Peptidase_S8"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR00723","properties":[{"key":"EntryName","value":"SUBTILISIN"}]},{"database":"SUPFAM","id":"SSF52743","properties":[{"key":"EntryName","value":"Subtilisin-like"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS51257","properties":[{"key":"EntryName","value":"PROKAR_LIPOPROTEIN"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS51892","properties":[{"key":"EntryName","value":"SUBTILASE"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00136","properties":[{"key":"EntryName","value":"SUBTILASE_ASP"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00137","properties":[{"key":"EntryName","value":"SUBTILASE_HIS"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MKKIITILSAALCAVFFACSPVINNSFTANGSNSFSGGLPYKPHKNDVVQGFVIAKTADGFDKTFFENQGIEVYGKLSLAGTGFTYWYVHQDTSNDTLLQAVYAIEGVLCADNDYKVTPPDGIKQSDFSSFAAGEPRISTQGLEQGNYLKDPISGKSAYSLDITKALQAYKDIGYGDKDVVAGIIDTGINMLHEDFKAGSESIVLYAKSAKTGPASSAPPIGDGDPFTEVPLNSNWDADGHGTHCSGIMCALGDNDKGIAGVAWKKTKLISYQSLGFAGGGTTWAVYGALADLTNTIEILRKVLATRTAADKVKLPSYIQNTNFQITQKTVPVNMSLGSSIGSDFAFAVLTNAIAHDVLPVIAMGNEGRYTAAYPAAFPGVLAVGATNGKDKKARFSNRGSWISVAAPGESIISCGVSDVNSYVSLS","length":427,"molWeight":45011,"crc64":"94F0C545CAF1F275","md5":"16969BEDD0FF72BC337ED655008843C4"},"extraAttributes":{"countByCommentType":{"SIMILARITY":1,"CAUTION":1},"countByFeatureType":{"Signal":1,"Chain":1,"Domain":1,"Active site":2,"Lipidation":2,"Non-terminal residue":1},"uniParcId":"UPI00000B753D"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"B2XCM2","uniProtkbId":"B2XCM2_TRELE","entryAudit":{"firstPublicDate":"2008-07-01","lastAnnotationUpdateDate":"2026-11-04","lastSequenceUpdateDate":"2008-07-01","entryVersion":52,"sequenceVersion":1},"annotationScore":1.0,"organism":{"scientificName":"Treponema lecithinolyticum","taxonId":53418,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ABW74625.1"}],"lineage":["Bacteria","Pseudomonadati","Spirochaetota","Spirochaetia","Treponematales","Treponemataceae","Treponema"]},"proteinExistence":"4: Predicted","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"NCBIfam","id":"TIGR03303"}],"value":"Outer membrane protein assembly factor BamA"}}},"comments":[{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004442"}],"value":"Cell outer membrane","id":"SL-0040"}}]}],"features":[{"type":"Signal","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":21,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}]},{"type":"Chain","location":{"start":{"value":22,"modifier":"EXACT"},"end":{"value":809,"modifier":"EXACT"}},"description":"Outer membrane protein assembly factor BamA","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"featureId":"PRO_5002783825"},{"type":"Domain","location":{"start":{"value":110,"modifier":"EXACT"},"end":{"value":186,"modifier":"EXACT"}},"description":"POTRA","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS51779"}]},{"type":"Domain","location":{"start":{"value":189,"modifier":"EXACT"},"end":{"value":277,"modifier":"EXACT"}},"description":"POTRA","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS51779"}]},{"type":"Domain","location":{"start":{"value":361,"modifier":"EXACT"},"end":{"value":434,"modifier":"EXACT"}},"description":"POTRA","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS51779"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023237"}],"id":"KW-0998","category":"Cellular component","name":"Cell outer membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023136"}],"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022737"}],"id":"KW-0677","category":"Domain","name":"Repeat"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022729"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"id":"KW-0732","category":"Domain","name":"Signal"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022692"}],"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022452"}],"id":"KW-1134","category":"Domain","name":"Transmembrane beta strand"}],"references":[{"referenceNumber":1,"citation":{"id":"CI-HBMBE4892VOD","citationType":"submission","authors":["Jun H.-K.","Kang Y.-M.","Choi B.-K."],"publicationDate":"JUL-2007","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ABW74625.1"}]},{"referenceNumber":2,"citation":{"id":"18390996","citationType":"journal article","authors":["Jun H.K.","Kang Y.M.","Lee H.R.","Lee S.H.","Choi B.K."],"citationCrossReferences":[{"database":"PubMed","id":"18390996"},{"database":"DOI","id":"10.1128/IAI.01128-07"}],"title":"Highly conserved surface proteins of oral spirochetes as adhesins and potent inducers of proinflammatory and osteoclastogenic factors.","publicationDate":"2008","journal":"Infect. Immun.","firstPage":"2428","lastPage":"2438","volume":"76"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ABW74625.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"EU057146","properties":[{"key":"ProteinId","value":"ABW74625.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"AlphaFoldDB","id":"B2XCM2","properties":[{"key":"Description","value":"-"}]},{"database":"GO","id":"GO:0009279","properties":[{"key":"GoTerm","value":"C:cell outer membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0071709","properties":[{"key":"GoTerm","value":"P:membrane assembly"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"Gene3D","id":"3.10.20.310","properties":[{"key":"EntryName","value":"membrane protein fhac"},{"key":"MatchStatus","value":"5"}]},{"database":"Gene3D","id":"2.40.160.50","properties":[{"key":"EntryName","value":"membrane protein fhac: a member of the omp85/tpsb transporter family"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR000184","properties":[{"key":"EntryName","value":"BamA-like"}]},{"database":"InterPro","id":"IPR010827","properties":[{"key":"EntryName","value":"BamA/TamA_POTRA"}]},{"database":"InterPro","id":"IPR039910","properties":[{"key":"EntryName","value":"D15-like"}]},{"database":"InterPro","id":"IPR023707","properties":[{"key":"EntryName","value":"OM_assembly_BamA"}]},{"database":"InterPro","id":"IPR034746","properties":[{"key":"EntryName","value":"POTRA"}]},{"database":"NCBIfam","id":"TIGR03303","properties":[{"key":"EntryName","value":"OM_YaeT"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR12815","properties":[{"key":"EntryName","value":"SORTING AND ASSEMBLY MACHINERY SAMM50 PROTEIN FAMILY MEMBER"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR12815:SF47","properties":[{"key":"EntryName","value":"TRANSLOCATION AND ASSEMBLY MODULE SUBUNIT TAMA"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF01103","properties":[{"key":"EntryName","value":"Omp85"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF07244","properties":[{"key":"EntryName","value":"POTRA"},{"key":"MatchStatus","value":"5"}]},{"database":"PIRSF","id":"PIRSF006076","properties":[{"key":"EntryName","value":"OM_assembly_OMP85"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS51779","properties":[{"key":"EntryName","value":"POTRA"},{"key":"MatchStatus","value":"3"}]}],"sequence":{"value":"MHSNRRVFTILCVCILSAVCALLPAQSESDWYYGKEIRNIRFVGLKAVKSADIDAVVSPFIGQNFSDELYTEILNKIYALEYFEEVTPLALPADSENKTVIIQFTVIERPVVKKLSFSGNSRLRTSELRDTVSVKESDVYIESKVLLDEQKLQNLYLEKGYTKAKVAREVTEVNGEINIVFNISEGQQTVVSAIRFQGNVIATEKNLKKNMKLKEVNLVQKGAFQESFLEADKQSLLLYYQNKGYIDAAVTDVVRETTYNAQKMRDELTITYVIKEGAQYLFDGMTIEGNVIFPTEQLQSLIKLKKGAIFNQTRFQESLAAIADLYYENGYTSNGFYPETNKNTETRLVSCVLHISEKPRSHIERILVTGNTKTKDYVILREIPLEPGDIFSKKKVETGLRSLYNLGFFSAVIPNIQSGSEENLVNLVVDVEERSTTAIEFGVTFSGVTDPSAWPVSLFANWKDSNFLGTGKTIGVNVTGSNDEQVLSFNFSDPWFLNKPLNFSAGFNIKHKALTALYYNYVPGGVNKSNYYMNYDQLSFGLEAALGKRWVWNFAAFTLTGGVANDFARNFYDNKLYVPVDTTVSDKYGKFGVQNSIWVKGALNARDVLSDPSKGWFASQQFKWTGLLPKLESEYFLRSDTKGEIYFTLLNKPMSETWNLKFVLAAYTGFSFLFPAQGSPIGKLNKLYIDGMFNGRGWASAGDQSSSLIGHAMWSSFAELRMPIAPGVFSLDFFTDVIAVKETPKKMFTELSGNDFFFSFGPGLRFSLPQFPLRLMWAWSFKTRDGAFEWNTSTKNTGKFVLSFNLTNQ","length":809,"molWeight":91254,"crc64":"EC6253674759E7FF","md5":"E3D66FC35077778AABB15C6DC67B56E9"},"extraAttributes":{"countByCommentType":{"SUBCELLULAR LOCATION":1},"countByFeatureType":{"Signal":1,"Chain":1,"Domain":3},"uniParcId":"UPI0001750D8E"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"Q6UKM5","uniProtkbId":"Q6UKM5_TRELE","entryAudit":{"firstPublicDate":"2004-07-05","lastAnnotationUpdateDate":"2026-11-04","lastSequenceUpdateDate":"2004-07-05","entryVersion":79,"sequenceVersion":1},"annotationScore":1.0,"organism":{"scientificName":"Treponema lecithinolyticum","taxonId":53418,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAQ73566.1"}],"lineage":["Bacteria","Pseudomonadati","Spirochaetota","Spirochaetia","Treponematales","Treponemataceae","Treponema"]},"proteinExistence":"3: Inferred from homology","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAQ73566.1"}],"value":"PrtPI"}}]},"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00011073"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU01240"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003355"}],"value":"Belongs to the peptidase S8 family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Signal","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":18,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}]},{"type":"Chain","location":{"start":{"value":19,"modifier":"EXACT"},"end":{"value":585,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00303"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"featureId":"PRO_5004280752"},{"type":"Domain","location":{"start":{"value":178,"modifier":"EXACT"},"end":{"value":481,"modifier":"EXACT"}},"description":"Peptidase S8/S53","evidences":[{"evidenceCode":"ECO:0000259","source":"Pfam","id":"PF00082"}]},{"type":"Active site","location":{"start":{"value":186,"modifier":"EXACT"},"end":{"value":186,"modifier":"EXACT"}},"description":"Charge relay system","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU10080"}]},{"type":"Active site","location":{"start":{"value":241,"modifier":"EXACT"},"end":{"value":241,"modifier":"EXACT"}},"description":"Charge relay system","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU10081"}]},{"type":"Active site","location":{"start":{"value":430,"modifier":"EXACT"},"end":{"value":430,"modifier":"EXACT"}},"description":"Charge relay system","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU10082"}]},{"type":"Lipidation","location":{"start":{"value":19,"modifier":"EXACT"},"end":{"value":19,"modifier":"EXACT"}},"description":"N-palmitoyl cysteine","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00303"}]},{"type":"Lipidation","location":{"start":{"value":19,"modifier":"EXACT"},"end":{"value":19,"modifier":"EXACT"}},"description":"S-diacylglycerol cysteine","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00303"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022801"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU01240"}],"id":"KW-0378","category":"Molecular function","name":"Hydrolase"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00303"}],"id":"KW-0449","category":"PTM","name":"Lipoprotein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00303"}],"id":"KW-0564","category":"PTM","name":"Palmitate"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022670"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU01240"}],"id":"KW-0645","category":"Molecular function","name":"Protease"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022825"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU01240"}],"id":"KW-0720","category":"Molecular function","name":"Serine protease"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00303"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"id":"KW-0732","category":"Domain","name":"Signal"}],"references":[{"referenceNumber":1,"citation":{"id":"14617650","citationType":"journal article","authors":["Correia F.F.","Plummer A.R.","Ellen R.P.","Wyss C.","Boches S.K.","Galvin J.L.","Paster B.J.","Dewhirst F.E."],"citationCrossReferences":[{"database":"PubMed","id":"14617650"},{"database":"DOI","id":"10.1128/JB.185.23.6860-6869.2003"}],"title":"Two paralogous families of a two-gene subtilisin operon are widely distributed in oral treponemes.","publicationDate":"2003","journal":"J. Bacteriol.","firstPage":"6860","lastPage":"6869","volume":"185"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAQ73566.1"}],"value":"OMZ 684","type":"STRAIN"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAQ73566.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AY368072","properties":[{"key":"ProteinId","value":"AAQ73566.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"AlphaFoldDB","id":"Q6UKM5","properties":[{"key":"Description","value":"-"}]},{"database":"MEROPS","id":"S08.024","properties":[{"key":"Description","value":"-"}]},{"database":"GO","id":"GO:0004252","properties":[{"key":"GoTerm","value":"F:serine-type endopeptidase activity"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniRule"}]},{"database":"GO","id":"GO:0006508","properties":[{"key":"GoTerm","value":"P:proteolysis"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"Gene3D","id":"3.40.50.200","properties":[{"key":"EntryName","value":"Peptidase S8/S53 domain"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR000209","properties":[{"key":"EntryName","value":"Peptidase_S8/S53_dom"}]},{"database":"InterPro","id":"IPR036852","properties":[{"key":"EntryName","value":"Peptidase_S8/S53_dom_sf"}]},{"database":"InterPro","id":"IPR023827","properties":[{"key":"EntryName","value":"Peptidase_S8_Asp-AS"}]},{"database":"InterPro","id":"IPR022398","properties":[{"key":"EntryName","value":"Peptidase_S8_His-AS"}]},{"database":"InterPro","id":"IPR023828","properties":[{"key":"EntryName","value":"Peptidase_S8_Ser-AS"}]},{"database":"InterPro","id":"IPR050131","properties":[{"key":"EntryName","value":"Peptidase_S8_subtilisin-like"}]},{"database":"InterPro","id":"IPR015500","properties":[{"key":"EntryName","value":"Peptidase_S8_subtilisin-rel"}]},{"database":"NCBIfam","id":"NF033595","properties":[{"key":"EntryName","value":"denti_PrtP"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR43806:SF11","properties":[{"key":"EntryName","value":"CEREVISIN-RELATED"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR43806","properties":[{"key":"EntryName","value":"PEPTIDASE S8"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00082","properties":[{"key":"EntryName","value":"Peptidase_S8"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR00723","properties":[{"key":"EntryName","value":"SUBTILISIN"}]},{"database":"SUPFAM","id":"SSF52743","properties":[{"key":"EntryName","value":"Subtilisin-like"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS51257","properties":[{"key":"EntryName","value":"PROKAR_LIPOPROTEIN"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS51892","properties":[{"key":"EntryName","value":"SUBTILASE"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00136","properties":[{"key":"EntryName","value":"SUBTILASE_ASP"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00137","properties":[{"key":"EntryName","value":"SUBTILASE_HIS"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00138","properties":[{"key":"EntryName","value":"SUBTILASE_SER"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MKKIITILSAALCAVFFACSPVINNSFTANGSNSFSGGLPYKPHKNDVVQGFVIAKTADGFDKTFFENQGIEVYGKLSLAGTGFTYWYVHQDTSNDTLLQAVYAIEGVLCADNDYKVTPPDGIKQSDFSSFAAGEPRISTQGLEQGNYLKDPISGKSAYSLDITKALQAYKDIGYGDKDVVAGIIDTGINMLHEDFKAGSESIVLYAKSAKTGPASSAPPIGDGDPFTEVPLNSNWDADGHGTHCSGIMCALGDNDKGIAGVAWKKTKLISYQSLGFAGGGTTWAVYGALADLTNTIEILRKVLATRTAADKVKLPSYIQNTNFQITQKTVPVNMSLGSSIGSDFAFAVLTNAIAHDVLPVIAMGNEGRYTAAYPAAFPGVLAVGATNGKDKKARFSNRGSWISVAAPGESIISCGVSDVNSYVSLSGTSMAAPFVTGFVSYLLSFDNARNLTPYQIKTMIEKTADKVDGVSSFDERFGHGRVNVLKAAQAVKDNTVPATNDVYSEGTVTVRVIGLGSPIKESLCLIDKALNIPLVYVPMNNSGKIPLKGLIKGKTYSVFISDGTKVKVQDFTAGISDQTVMINW","length":585,"molWeight":62071,"crc64":"2287E1EE57F4BBBF","md5":"3261E7C94A55593EBB7471843B3E1162"},"extraAttributes":{"countByCommentType":{"SIMILARITY":1},"countByFeatureType":{"Signal":1,"Chain":1,"Domain":1,"Active site":3,"Lipidation":2},"uniParcId":"UPI00001C177F"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"Q6UKM6","uniProtkbId":"Q6UKM6_TRELE","entryAudit":{"firstPublicDate":"2004-07-05","lastAnnotationUpdateDate":"2026-11-04","lastSequenceUpdateDate":"2004-07-05","entryVersion":22,"sequenceVersion":1},"annotationScore":1.0,"organism":{"scientificName":"Treponema lecithinolyticum","taxonId":53418,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAQ73565.1"}],"lineage":["Bacteria","Pseudomonadati","Spirochaetota","Spirochaetia","Treponematales","Treponemataceae","Treponema"]},"proteinExistence":"4: Predicted","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAQ73565.1"}],"value":"PrcAI"}}]},"features":[{"type":"Signal","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":23,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}]},{"type":"Chain","location":{"start":{"value":24,"modifier":"EXACT"},"end":{"value":610,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00303"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"featureId":"PRO_5048869045"},{"type":"Lipidation","location":{"start":{"value":24,"modifier":"EXACT"},"end":{"value":24,"modifier":"EXACT"}},"description":"N-palmitoyl cysteine","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00303"}]},{"type":"Lipidation","location":{"start":{"value":24,"modifier":"EXACT"},"end":{"value":24,"modifier":"EXACT"}},"description":"S-diacylglycerol cysteine","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00303"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00303"}],"id":"KW-0449","category":"PTM","name":"Lipoprotein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00303"}],"id":"KW-0564","category":"PTM","name":"Palmitate"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00303"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"id":"KW-0732","category":"Domain","name":"Signal"}],"references":[{"referenceNumber":1,"citation":{"id":"14617650","citationType":"journal article","authors":["Correia F.F.","Plummer A.R.","Ellen R.P.","Wyss C.","Boches S.K.","Galvin J.L.","Paster B.J.","Dewhirst F.E."],"citationCrossReferences":[{"database":"PubMed","id":"14617650"},{"database":"DOI","id":"10.1128/JB.185.23.6860-6869.2003"}],"title":"Two paralogous families of a two-gene subtilisin operon are widely distributed in oral treponemes.","publicationDate":"2003","journal":"J. Bacteriol.","firstPage":"6860","lastPage":"6869","volume":"185"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAQ73565.1"}],"value":"OMZ 684","type":"STRAIN"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAQ73565.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AY368072","properties":[{"key":"ProteinId","value":"AAQ73565.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"AlphaFoldDB","id":"Q6UKM6","properties":[{"key":"Description","value":"-"}]},{"database":"InterPro","id":"IPR061403","properties":[{"key":"EntryName","value":"PrcA"}]},{"database":"NCBIfam","id":"NF033597","properties":[{"key":"EntryName","value":"denti_PrcA"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS51257","properties":[{"key":"EntryName","value":"PROKAR_LIPOPROTEIN"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MKTAWKTACSALCLCALLVWVTSCPQSAGNGGASTDFTTLYVSVTDSIGGTAVDGTTLRVYESGNTLQFQSDFRVTNGKVRVSGISTNKRYDFELIGIKGKWAGSRLENYSPLKKAEQTLSIIQSEHAMITRGITPPKITSIQSGNGTFTDIDESTVISSSDKVRVVFDSDVGAVEETASGAFGAKLGIDKAPNNLSGIHGRYSVSQAGGVIKSTYTFSFSEVPNGTGELIAVGYDVAHNRIEKHIPVTFQSSSAAASDLSTCTFDKLSVNTERLPFSENLFSLNPVENRRSSYRVLVRFTLKKFGIDEKILGFDLYRKKNGYAQDFRFVSRTLYNELKNETQSGWGFHVGIDSDSLLEEDTEYEYKIRVFNKLNEKYSPVIKTKVLKSFTYDLTAPAQNAFVSFANAANLTYKCKMSNTHLLDAGQSDYMICGLLIKDFRGIPLFGAKLIYVFNAGGNPDILIEVCDRVTGMLQSQLKRGSELIATGKLNSYDIYSLDDLVKVDKATGVIEFTEKLVKVPFFNVIPISGGKGLNLPMIYEKGTSYQWDIQDWGSNSVSLNDDTALNFVKMYSYIDENAQIKYCRAASYGNNSSSGANAVNGCFTFTVGN","length":610,"molWeight":66899,"crc64":"E4A790ED494319FB","md5":"6FDC191FBE2836DDEDB8313BA973F5AC"},"extraAttributes":{"countByFeatureType":{"Signal":1,"Chain":1,"Lipidation":2},"uniParcId":"UPI00001C177E"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"Q6UKM8","uniProtkbId":"Q6UKM8_TRELE","entryAudit":{"firstPublicDate":"2004-07-05","lastAnnotationUpdateDate":"2026-11-04","lastSequenceUpdateDate":"2004-07-05","entryVersion":35,"sequenceVersion":1},"annotationScore":1.0,"organism":{"scientificName":"Treponema lecithinolyticum","taxonId":53418,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAQ73563.1"}],"lineage":["Bacteria","Pseudomonadati","Spirochaetota","Spirochaetia","Treponematales","Treponemataceae","Treponema"]},"proteinExistence":"4: Predicted","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAQ73563.1"}],"value":"PrcAII"}}]},"features":[{"type":"Signal","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":24,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}]},{"type":"Chain","location":{"start":{"value":25,"modifier":"EXACT"},"end":{"value":627,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00303"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"featureId":"PRO_5049689428"},{"type":"Lipidation","location":{"start":{"value":25,"modifier":"EXACT"},"end":{"value":25,"modifier":"EXACT"}},"description":"N-palmitoyl cysteine","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00303"}]},{"type":"Lipidation","location":{"start":{"value":25,"modifier":"EXACT"},"end":{"value":25,"modifier":"EXACT"}},"description":"S-diacylglycerol cysteine","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00303"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00303"}],"id":"KW-0449","category":"PTM","name":"Lipoprotein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00303"}],"id":"KW-0564","category":"PTM","name":"Palmitate"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00303"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"id":"KW-0732","category":"Domain","name":"Signal"}],"references":[{"referenceNumber":1,"citation":{"id":"14617650","citationType":"journal article","authors":["Correia F.F.","Plummer A.R.","Ellen R.P.","Wyss C.","Boches S.K.","Galvin J.L.","Paster B.J.","Dewhirst F.E."],"citationCrossReferences":[{"database":"PubMed","id":"14617650"},{"database":"DOI","id":"10.1128/JB.185.23.6860-6869.2003"}],"title":"Two paralogous families of a two-gene subtilisin operon are widely distributed in oral treponemes.","publicationDate":"2003","journal":"J. Bacteriol.","firstPage":"6860","lastPage":"6869","volume":"185"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAQ73563.1"}],"value":"OMZ 684","type":"STRAIN"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAQ73563.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AY368071","properties":[{"key":"ProteinId","value":"AAQ73563.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"AlphaFoldDB","id":"Q6UKM8","properties":[{"key":"Description","value":"-"}]},{"database":"CDD","id":"cd00063","properties":[{"key":"EntryName","value":"FN3"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.60.40.10","properties":[{"key":"EntryName","value":"Immunoglobulins"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR003961","properties":[{"key":"EntryName","value":"FN3_dom"}]},{"database":"InterPro","id":"IPR036116","properties":[{"key":"EntryName","value":"FN3_sf"}]},{"database":"InterPro","id":"IPR013783","properties":[{"key":"EntryName","value":"Ig-like_fold"}]},{"database":"InterPro","id":"IPR061403","properties":[{"key":"EntryName","value":"PrcA"}]},{"database":"NCBIfam","id":"NF033597","properties":[{"key":"EntryName","value":"denti_PrcA"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF49265","properties":[{"key":"EntryName","value":"Fibronectin type III"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS51257","properties":[{"key":"EntryName","value":"PROKAR_LIPOPROTEIN"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MKYSQFTRYTAFCFLCALVCFFTSCPNGAQQNGIYASGTAVTVNILDSVGGTPQMESTILSAYKAGTKSAACQPVTVSGGSAQLYLPEGQCYDLYLSGEKNKLAASVIENYWVKSANAQTVTMFQRTPQQGAATEAPSVQSVKLNGVPFEDSGVWAGAVDKPMVLEIVLRAPSRAIQAVPTNGNFGCAVAVGSSPSSRNKIASVSPECVRNGDGSWTCTARFNFDKISFPNKTDDFIISAYDTAGNRVERHINSIEFKERRPALTDISGSSVKDFRIEMHRFPHSLKLFSLPDQSAISPFGIRSHNGESNTYEVLLYFRVKDASSQDLPIRGYDIYRRLQGQTEWTHIGQRQYVADYAGENNPNWPSYKGYHLGYDTDTSLEENVTYEYQVRPFNGSGKNLVSPTATARLLPANTIELQSPADNGFVKKSKLNNLSFSFRLTNPDIWEHKLADSFSFGLFVTEKTSNQKIIFAGKATFYLKKNGGEKLALQYAISGTPQEYSFKELQTRGVIASNLTEDDFISYKDGVITIKPAYLITEGFNHPQCKDEKFQTGVTYAWDIFDWGKRLKETYDDEPAAFSAAWKSKDVDGNEIGTDIEPLSSSESFANAIRYASSSNGQYFFRVTAE","length":627,"molWeight":69361,"crc64":"31560D365F4E1136","md5":"0C2D628EB9167C32427381D09B49B41D"},"extraAttributes":{"countByFeatureType":{"Signal":1,"Chain":1,"Lipidation":2},"uniParcId":"UPI00001C177C"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"Q8VLY4","uniProtkbId":"Q8VLY4_TRELE","entryAudit":{"firstPublicDate":"2002-03-01","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2002-03-01","entryVersion":19,"sequenceVersion":1},"annotationScore":1.0,"organism":{"scientificName":"Treponema lecithinolyticum","taxonId":53418,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"CAC81266.1"}],"lineage":["Bacteria","Pseudomonadati","Spirochaetota","Spirochaetia","Treponematales","Treponemataceae","Treponema"]},"proteinExistence":"4: Predicted","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"CAC81266.1"}],"value":"43 kDa protein"}}],"flag":"Fragment"},"features":[{"type":"Non-terminal residue","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":1,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"CAC81266.1"}]}],"references":[{"referenceNumber":1,"citation":{"id":"11470357","citationType":"journal article","authors":["Heuner K.","Bergmann I.","Heckenbach K.","Goebel U.B."],"citationCrossReferences":[{"database":"PubMed","id":"11470357"}],"title":"Proteolytic activity among various oral Treponema species and cloning of a prtP-like gene of Treponema socranskii subsp. socranskii.","publicationDate":"2001","journal":"FEMS Microbiol. Lett.","firstPage":"169","lastPage":"176","volume":"201"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"CAC81266.1"}],"value":"ATCC 700332","type":"STRAIN"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"CAC81266.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AJ272340","properties":[{"key":"ProteinId","value":"CAC81266.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"AlphaFoldDB","id":"Q8VLY4","properties":[{"key":"Description","value":"-"}]}],"sequence":{"value":"DWGSNSVSLNDDTALNFVKMYSYIDENAQIKYCRAASYGNNSSSGANAVNGCFTFTVGN","length":59,"molWeight":6354,"crc64":"1DE5757529530151","md5":"8D2D6A8F822C584FC7A52556C7077CD6"},"extraAttributes":{"countByFeatureType":{"Non-terminal residue":1},"uniParcId":"UPI00000B0807"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"Q9AJS6","uniProtkbId":"Q9AJS6_TRELE","entryAudit":{"firstPublicDate":"2001-06-01","lastAnnotationUpdateDate":"2026-11-04","lastSequenceUpdateDate":"2001-06-01","entryVersion":72,"sequenceVersion":1},"annotationScore":1.0,"organism":{"scientificName":"Treponema lecithinolyticum","taxonId":53418,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"CAC32470.1"}],"lineage":["Bacteria","Pseudomonadati","Spirochaetota","Spirochaetia","Treponematales","Treponemataceae","Treponema"]},"proteinExistence":"3: Inferred from homology","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"CAC32470.1"}],"value":"Chymotrypsin-like proteinase"}}],"flag":"Fragment"},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"CAC32470.1"}],"value":"prtP2"}}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00011073"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU01240"}],"value":"Belongs to the peptidase S8 family"}],"commentType":"SIMILARITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU01240"}],"value":"Lacks conserved residue(s) required for the propagation of feature annotation"}],"commentType":"CAUTION"}],"features":[{"type":"Domain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":178,"modifier":"EXACT"}},"description":"Peptidase S8/S53","evidences":[{"evidenceCode":"ECO:0000259","source":"Pfam","id":"PF00082"}]},{"type":"Non-terminal residue","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":1,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"CAC32470.1"}]},{"type":"Non-terminal residue","location":{"start":{"value":192,"modifier":"EXACT"},"end":{"value":192,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"CAC32470.1"}]}],"references":[{"referenceNumber":1,"citation":{"id":"11470357","citationType":"journal article","authors":["Heuner K.","Bergmann I.","Heckenbach K.","Goebel U.B."],"citationCrossReferences":[{"database":"PubMed","id":"11470357"}],"title":"Proteolytic activity among various oral Treponema species and cloning of a prtP-like gene of Treponema socranskii subsp. socranskii.","publicationDate":"2001","journal":"FEMS Microbiol. Lett.","firstPage":"169","lastPage":"176","volume":"201"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"CAC32470.1"}],"value":"ATCC 700332","type":"STRAIN"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"CAC32470.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AJ272426","properties":[{"key":"ProteinId","value":"CAC32470.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"AlphaFoldDB","id":"Q9AJS6","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"Q9AJS6","properties":[{"key":"Description","value":"-"}]},{"database":"MEROPS","id":"S08.024","properties":[{"key":"Description","value":"-"}]},{"database":"GO","id":"GO:0004252","properties":[{"key":"GoTerm","value":"F:serine-type endopeptidase activity"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0006508","properties":[{"key":"GoTerm","value":"P:proteolysis"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"Gene3D","id":"3.40.50.200","properties":[{"key":"EntryName","value":"Peptidase S8/S53 domain"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR000209","properties":[{"key":"EntryName","value":"Peptidase_S8/S53_dom"}]},{"database":"InterPro","id":"IPR036852","properties":[{"key":"EntryName","value":"Peptidase_S8/S53_dom_sf"}]},{"database":"InterPro","id":"IPR050131","properties":[{"key":"EntryName","value":"Peptidase_S8_subtilisin-like"}]},{"database":"NCBIfam","id":"NF033595","properties":[{"key":"EntryName","value":"denti_PrtP"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR43806:SF11","properties":[{"key":"EntryName","value":"CEREVISIN-RELATED"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR43806","properties":[{"key":"EntryName","value":"PEPTIDASE S8"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00082","properties":[{"key":"EntryName","value":"Peptidase_S8"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF52743","properties":[{"key":"EntryName","value":"Subtilisin-like"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS51892","properties":[{"key":"EntryName","value":"SUBTILASE"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"CAGTIAAVGNNGKGICGVSHANTKLITYRGLGKTGGSSYSVYSCLGDLAQIISELRKEPGSRNPALFAGLPAEVSAYPKLTQKTVPVNISLGGYSIHPYEVEMMNKALAAGVLPVIAMANDGKTIASYPAALQGVLAVGATSMDDTKAAFSNGGSWISVCAPGDSIYSCYNNGTNWSNTAAPELRKSYTWMS","length":192,"molWeight":19865,"crc64":"7E0C7B1AF6B8BA73","md5":"2D39B6CD46E855EA6FE4F9FCB51DAD0B"},"extraAttributes":{"countByCommentType":{"SIMILARITY":1,"CAUTION":1},"countByFeatureType":{"Domain":1,"Non-terminal residue":2},"uniParcId":"UPI00000BE778"}}]}