{"results":[{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0ABF7PQB8","uniProtkbId":"A0ABF7PQB8_9GAMM","entryAudit":{"firstPublicDate":"2025-06-18","lastAnnotationUpdateDate":"2026-11-04","lastSequenceUpdateDate":"2025-06-18","entryVersion":5,"sequenceVersion":1},"annotationScore":1.0,"organism":{"scientificName":"Pseudoalteromonas","taxonId":53246,"evidences":[{"evidenceCode":"ECO:0000313","source":"PDB","id":"9GS9"}],"lineage":["Bacteria","Pseudomonadati","Pseudomonadota","Gammaproteobacteria","Alteromonadales","Pseudoalteromonadaceae"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"PDB","id":"9GS9"}],"value":"Cas8"}}]},"keywords":[{"evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"30GA"},{"evidenceCode":"ECO:0007829","source":"PDB","id":"30GB"}],"id":"KW-0002","category":"Technical term","name":"3D-structure"}],"references":[{"referenceNumber":1,"citation":{"id":"CI-F6HSJ9AJP41RV","citationType":"journal article","authors":["Lampe G.D.","Liang A.R.","Zhang D.J.","Fernandez I.S.","Sternberg S.H."],"citationCrossReferences":[{"database":"DOI","id":"10.1101/2024.09.19.613948"}],"title":"Structure-guided engineering of type I-F CASTs for targeted gene insertion in human cells.","publicationDate":"2024","journal":"bioRxiv","firstPage":"0","lastPage":"0","volume":"0"},"referencePositions":["STRUCTURE BY ELECTRON MICROSCOPY (2.60 ANGSTROMS)"],"evidences":[{"evidenceCode":"ECO:0000313","source":"PDB","id":"9GS9"},{"evidenceCode":"ECO:0007829","source":"PDB","id":"9GS9"}]},{"referenceNumber":2,"citation":{"id":"CI-2UASHBNTBEQ5L","citationType":"journal article","authors":["Finocchio G.","Oberli S.","Lampe G.","Schmitz M.","Sternberg S.H.","Jinek M."],"citationCrossReferences":[{"database":"DOI","id":"10.64898/2026.05.18.725949"}],"title":"Structural basis of RNA-guided DNA integration by type I CRISPR-associated transposases.","publicationDate":"2026","journal":"bioRxiv","firstPage":"0","lastPage":"0","volume":"0"},"referencePositions":["STRUCTURE BY ELECTRON MICROSCOPY"],"evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"30GA"},{"evidenceCode":"ECO:0007829","source":"PDB","id":"30GB"}]}],"uniProtKBCrossReferences":[{"database":"PDB","id":"30GA","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.20 A"},{"key":"Chains","value":"G=1-695"}]},{"database":"PDB","id":"30GB","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"2.90 A"},{"key":"Chains","value":"G=1-695"}]},{"database":"PDB","id":"30GT","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.30 A"},{"key":"Chains","value":"G=1-695"}]},{"database":"PDB","id":"9GS9","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"2.60 A"},{"key":"Chains","value":"A=1-695"}]},{"database":"AlphaFoldDB","id":"A0ABF7PQB8","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-51543","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-57736","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-57739","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-57765","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"A0ABF7PQB8","properties":[{"key":"Description","value":"-"}]},{"database":"InterPro","id":"IPR013398","properties":[{"key":"EntryName","value":"CRISPR-assoc_prot_Csy2"}]},{"database":"Pfam","id":"PF09614","properties":[{"key":"EntryName","value":"Cas_Csy2"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MHLKELLEITDTTERDRSLRRAFSPYTAMIDITGSEAVALIILLNLTYRKNQVDDLLDKKLAKQALKSEDHINKCIKEIAWFHTHNLKYPDIRVSKQNLAVEPPTLHSYVLSSANYPKAYGWSHNSAKVNFAKLFVSYFKWQNQVSWLAQVLATNSDNWKSAFTSLGLSVKAFKSLCVTVKNSLPEEAIPDSVDRYSRQIRMPYHDGYLAVTPVISHVVQSKIQQAAIDKRARFSNVEFTRPAAVSMLAASLGGVINVLNYPPYIRSKYHGLSNSRAFKLNNGQTVFNVEALLKPELIKALEGIIFSNNALALKQRRQQKVKNIKELRNTLLEWFSPVFEWRLDAIENGYDLEQLESASERLEYKILSLPDNELPSLTIPLFRLLNEMLGGVSMTQRYAFHPKLMSPLKAALQWLLVNLTDQKHVLIEEDDEHYRYLHLSGIRVFDAQALSNPYCSGIPSLTAVWGMIHSYQRKLNEALGTNVRFTSFSWFIRNYSAVAGKKLPELSLQGAQQSRLKRPGIIDGKYCDLVFDLIIHIDGYEDDLQAVDSKPDILKAHFPSNFAGGVMHQPELNSNINWCCLYSNENQLFEKLRRLPLSGCWVMPTEHKIQDLDELLLLLNSDSKLSPSMMGYMLLTEPMARVGSLERLHCYAEPAIGVVKYEAATSVRLKGIGNYFNSAFWMLDAQEKFMLMKKV","length":695,"molWeight":79191,"crc64":"EF443547B68965FF","md5":"0AA844C7774A3196990164690EA91C3E"},"extraAttributes":{"uniParcId":"UPI00110AA692"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0ABF7PQB9","uniProtkbId":"A0ABF7PQB9_9GAMM","entryAudit":{"firstPublicDate":"2025-06-18","lastAnnotationUpdateDate":"2026-11-04","lastSequenceUpdateDate":"2025-06-18","entryVersion":5,"sequenceVersion":1},"annotationScore":1.0,"organism":{"scientificName":"Pseudoalteromonas","taxonId":53246,"evidences":[{"evidenceCode":"ECO:0000313","source":"PDB","id":"9GS9"}],"lineage":["Bacteria","Pseudomonadati","Pseudomonadota","Gammaproteobacteria","Alteromonadales","Pseudoalteromonadaceae"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"PDB","id":"9GS9"}],"value":"Cas7.1"}}]},"features":[{"type":"Disulfide bond","location":{"start":{"value":121,"modifier":"EXACT"},"end":{"value":316,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"9GS9"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"30GA"},{"evidenceCode":"ECO:0007829","source":"PDB","id":"30GB"}],"id":"KW-0002","category":"Technical term","name":"3D-structure"}],"references":[{"referenceNumber":1,"citation":{"id":"CI-F6HSJ9AJP41RV","citationType":"journal article","authors":["Lampe G.D.","Liang A.R.","Zhang D.J.","Fernandez I.S.","Sternberg S.H."],"citationCrossReferences":[{"database":"DOI","id":"10.1101/2024.09.19.613948"}],"title":"Structure-guided engineering of type I-F CASTs for targeted gene insertion in human cells.","publicationDate":"2024","journal":"bioRxiv","firstPage":"0","lastPage":"0","volume":"0"},"referencePositions":["STRUCTURE BY ELECTRON MICROSCOPY (2.60 ANGSTROMS)"],"evidences":[{"evidenceCode":"ECO:0000313","source":"PDB","id":"9GS9"},{"evidenceCode":"ECO:0007829","source":"PDB","id":"9GS9"}]},{"referenceNumber":2,"citation":{"id":"CI-2UASHBNTBEQ5L","citationType":"journal article","authors":["Finocchio G.","Oberli S.","Lampe G.","Schmitz M.","Sternberg S.H.","Jinek M."],"citationCrossReferences":[{"database":"DOI","id":"10.64898/2026.05.18.725949"}],"title":"Structural basis of RNA-guided DNA integration by type I CRISPR-associated transposases.","publicationDate":"2026","journal":"bioRxiv","firstPage":"0","lastPage":"0","volume":"0"},"referencePositions":["STRUCTURE BY ELECTRON MICROSCOPY"],"evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"30GA"},{"evidenceCode":"ECO:0007829","source":"PDB","id":"30GB"}]}],"uniProtKBCrossReferences":[{"database":"PDB","id":"30GA","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.20 A"},{"key":"Chains","value":"A/B/C/D/E/F=1-350"}]},{"database":"PDB","id":"30GB","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"2.90 A"},{"key":"Chains","value":"A/B/C/D/E/F=1-350"}]},{"database":"PDB","id":"30GT","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.30 A"},{"key":"Chains","value":"A/B/C/D/E/F=1-350"}]},{"database":"PDB","id":"9GS9","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"2.60 A"},{"key":"Chains","value":"B/C/D/E/F/G=1-350"}]},{"database":"AlphaFoldDB","id":"A0ABF7PQB9","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-51543","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-57736","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-57739","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-57765","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"A0ABF7PQB9","properties":[{"key":"Description","value":"-"}]},{"database":"InterPro","id":"IPR013399","properties":[{"key":"EntryName","value":"CRISPR-assoc_prot_Csy3"}]},{"database":"NCBIfam","id":"TIGR02566","properties":[{"key":"EntryName","value":"cas_Csy3"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF09615","properties":[{"key":"EntryName","value":"Cas_Csy3"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MELCNILKYDRSLYPGKAVFFYKTADSDFVPLEADINKIRGPKSGFTEAFTPQFSPKNISPQDLTHNNILTLEECYVPPNVEHIFCRFSLRVQANSLVPSGCSDPEVFSLLKELAETFKECGGYKELAVRYCRNILIGTWLWRNQNTGNTQIEIKTSKGSCYLIDNTRKLAWESKWASDDLKVLEELSNEIESALTDPNVFWSADITAKIEASFCQEIYPSQILNDKVKQGEASKQFVKAKCADGRYAVSFNSVKIGAALQSIDDWWDEDASKRLRVHEFGADKEIGVARRPPDSEQNFYSIFKNTEWYLSALKNCITNKNEKIDPAIYYLFSVLIKGGMFQKKAEAKKA","length":350,"molWeight":39797,"crc64":"3A6F635AC2C71A64","md5":"7A83419EB7AFAF64A94C23632976C502"},"extraAttributes":{"countByFeatureType":{"Disulfide bond":1},"uniParcId":"UPI00110AB2F0"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0ABF7PQC0","uniProtkbId":"A0ABF7PQC0_9GAMM","entryAudit":{"firstPublicDate":"2025-06-18","lastAnnotationUpdateDate":"2026-11-04","lastSequenceUpdateDate":"2025-06-18","entryVersion":6,"sequenceVersion":1},"annotationScore":1.0,"organism":{"scientificName":"Pseudoalteromonas","taxonId":53246,"evidences":[{"evidenceCode":"ECO:0000313","source":"PDB","id":"9GS9"}],"lineage":["Bacteria","Pseudomonadati","Pseudomonadota","Gammaproteobacteria","Alteromonadales","Pseudoalteromonadaceae"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"PDB","id":"9GS9"}],"value":"Cas6"}}]},"keywords":[{"evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"30GA"},{"evidenceCode":"ECO:0007829","source":"PDB","id":"30GB"}],"id":"KW-0002","category":"Technical term","name":"3D-structure"}],"references":[{"referenceNumber":1,"citation":{"id":"CI-F6HSJ9AJP41RV","citationType":"journal article","authors":["Lampe G.D.","Liang A.R.","Zhang D.J.","Fernandez I.S.","Sternberg S.H."],"citationCrossReferences":[{"database":"DOI","id":"10.1101/2024.09.19.613948"}],"title":"Structure-guided engineering of type I-F CASTs for targeted gene insertion in human cells.","publicationDate":"2024","journal":"bioRxiv","firstPage":"0","lastPage":"0","volume":"0"},"referencePositions":["STRUCTURE BY ELECTRON MICROSCOPY (2.60 ANGSTROMS)"],"evidences":[{"evidenceCode":"ECO:0000313","source":"PDB","id":"9GS9"},{"evidenceCode":"ECO:0007829","source":"PDB","id":"9GS9"}]},{"referenceNumber":2,"citation":{"id":"CI-2UASHBNTBEQ5L","citationType":"journal article","authors":["Finocchio G.","Oberli S.","Lampe G.","Schmitz M.","Sternberg S.H.","Jinek M."],"citationCrossReferences":[{"database":"DOI","id":"10.64898/2026.05.18.725949"}],"title":"Structural basis of RNA-guided DNA integration by type I CRISPR-associated transposases.","publicationDate":"2026","journal":"bioRxiv","firstPage":"0","lastPage":"0","volume":"0"},"referencePositions":["STRUCTURE BY ELECTRON MICROSCOPY"],"evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"30GA"},{"evidenceCode":"ECO:0007829","source":"PDB","id":"30GB"}]}],"uniProtKBCrossReferences":[{"database":"PDB","id":"30GA","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.20 A"},{"key":"Chains","value":"H=1-203"}]},{"database":"PDB","id":"30GB","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"2.90 A"},{"key":"Chains","value":"H=1-203"}]},{"database":"PDB","id":"30GT","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.30 A"},{"key":"Chains","value":"H=1-203"}]},{"database":"PDB","id":"9GS9","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"2.60 A"},{"key":"Chains","value":"H=1-203"}]},{"database":"AlphaFoldDB","id":"A0ABF7PQC0","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-51543","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-57736","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-57739","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-57765","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"A0ABF7PQC0","properties":[{"key":"Description","value":"-"}]},{"database":"GO","id":"GO:0004519","properties":[{"key":"GoTerm","value":"F:endonuclease activity"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0043571","properties":[{"key":"GoTerm","value":"P:maintenance of CRISPR repeat elements"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"Gene3D","id":"3.30.70.2540","properties":[{"key":"EntryName","value":"CRISPR-associated endoribonuclease Cas6/Csy4"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR013396","properties":[{"key":"EntryName","value":"CRISPR-assoc_prot_Csy4"}]},{"database":"InterPro","id":"IPR042564","properties":[{"key":"EntryName","value":"CRISPR-Cas6/Csy4_sf"}]},{"database":"NCBIfam","id":"TIGR02563","properties":[{"key":"EntryName","value":"cas_Csy4"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF09618","properties":[{"key":"EntryName","value":"Cas_Csy4"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MQRYYFTVHFLPKQANLALLTGRCISIMHGFILKHNIEGMGVTFPAWSDSSIGNEIAFVYTDKEILNTLKDQAYFVDMQDCGFFKVSQVLAVPDSCEEVRFIRNQAVAKIFTGESRRRLKRLQKRALARGEDFNPKKIEAPREIDIFHRVAMTSKSSQEDYILHIQKQDVDCQAEPYFSNYGLASNEKFKGTVPDLSPSIDRN","length":203,"molWeight":23310,"crc64":"6FAEAB840BAD8533","md5":"CDB4CDEB6A61F6EE0E5EF06D6118F945"},"extraAttributes":{"uniParcId":"UPI0003FB96AE"}}]}